Academic literature on the topic 'Addenbrooke's Cognitive Examination'
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Journal articles on the topic "Addenbrooke's Cognitive Examination"
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Larner, Andrew. "MINI-ADDENBROOKE'S COGNITIVE EXAMINATION (M-ACE): PRAGMATIC STUDY." Journal of Neurology, Neurosurgery & Psychiatry 86, no. 11 (October 14, 2015): e4.139-e4. http://dx.doi.org/10.1136/jnnp-2015-312379.49.
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ObjectiveTo test diagnostic accuracy of the mini-Addenbrooke's Cognitive Examination (m-ACE) compared to the MMSE for the diagnosis of dementia and MCI in consecutive referrals to a dedicated cognitive disorders clinic.Results: Of 135 consecutive new outpatients seen over 6 months (June–November 2014) administered the mini-ACE (F:M=64:71, 47% female; age range 18–88 years, median 60), 24 were diagnosed with dementia (DSM–IV–TR criteria) and 39 had MCI (Petersen criteria). Using the cutoffs defined in the index paper (≤25/30 and ≤21/30), m-ACE was sensitive (1.00, 0.92) but not specific (0.28, 0.61) for dementia diagnosis; it also proved useful for MCI diagnosis (sensitivities 1.00, 0.77; specificities 0.43, 0.82). Area under the ROC curve was 0.86. Effect size (Cohen's d) for m-ACE for dementia vs. no dementia was 1.53 (large) and for MCI vs no cognitive impairment was 1.59 (large); for MMSE the corresponding figures were 1.56 and 1.26. Weighted comparison suggested a small net loss for m-ACE vs MMSE for dementia diagnosis (–0.13) but a large net benefit for MCI diagnosis (0.38).Conclusions: In this pragmatic study, m-ACE proved quick, easy to use, and acceptable to patients, with metrics comparable to MMSE for dementia diagnosis and better for MCI diagnosis.
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Matías-Guiu, Jordi A., Vanesa Pytel, Ana Cortés-Martínez, María Valles-Salgado, Teresa Rognoni, Teresa Moreno-Ramos, and Jorge Matías-Guiu. "Conversion between Addenbrooke's Cognitive Examination III and Mini-Mental State Examination." International Psychogeriatrics 30, no. 8 (December 10, 2017): 1227–33. http://dx.doi.org/10.1017/s104161021700268x.
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ABSTRACTBackground:We aim to provide a conversion between Addenbrooke's Cognitive Examination III (ACE-III) and Mini-Mental State Examination (MMSE) scores, to predict the MMSE result based on ACE-III, thus avoiding the need for both tests, and improving their comparability.Methods:Equipercentile equating method was used to elaborate a conversion table using a group of 400 participants comprising healthy controls and Alzheimer's disease (AD) patients. Then, reliability was assessed in a group of 100 healthy controls and patients with AD, 52 with primary progressive aphasia and 22 with behavioral variant frontotemporal dementia.Results:The conversion table between ACE-III and MMSE denoted a high reliability, with intra-class correlation coefficients of 0.940, 0.922, and 0.902 in the groups of healthy controls and AD, behavioral variant frontotemporal dementia, and primary progressive aphasia, respectively.Conclusion:Our conversion table between ACE-III and MMSE suggests that MMSE may be estimated based on the ACE-III score, which could be useful for clinical and research purposes.
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McColgan, Peter, Jonathan R. Evans, David P. Breen, Sarah L. Mason, Roger A. Barker, and Caroline H. Williams-Gray. "Addenbrooke's Cognitive Examination-Revised for mild cognitive impairment in Parkinson's disease." Movement Disorders 27, no. 9 (June 25, 2012): 1173–77. http://dx.doi.org/10.1002/mds.25084.
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Larner, A. J. "Mini-Addenbrooke's Cognitive Examination: a pragmatic diagnostic accuracy study." International Journal of Geriatric Psychiatry 30, no. 5 (April 8, 2015): 547–48. http://dx.doi.org/10.1002/gps.4258.
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Charernboon, Thammanard, Kankamol Jaisin, and Tiraya Lerthattasilp. "The Thai Version of the Addenbrooke's Cognitive Examination III." Psychiatry Investigation 13, no. 5 (2016): 571. http://dx.doi.org/10.4306/pi.2016.13.5.571.
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Carvalho, Viviane Amaral, and Paulo Caramelli. "Brazilian adaptation of the Addenbrooke's Cognitive Examination-Revised (ACE-R)." Dementia & Neuropsychologia 1, no. 2 (June 2007): 212–16. http://dx.doi.org/10.1590/s1980-57642008dn10200015.
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Abstract The Addenbrooke's Cognitive Examination-Revised (ACE-R) is a highly sensitive and specific tool for the detection of mild dementia. It is particularly useful in differentiating Alzheimer's disease from frontotemporal dementia. While the first version of the test battery has been adapted in many countries, its revised version has not, probably because it was published very recently. Objective: To translate and adapt the ACE-R for use in the Brazilian population. Methods: Two independent translations were made from English into Portuguese, followed by two independent back-translations. Few adaptations in accordance to the Brazilian culture and language were made and a first version of the instrument produced. This former version of the ACE-R was administered to 21 cognitively healthy subjects aged 60 years or more, with different educational levels. Results: The mean age of the studied sample of healthy elderly was 75.4 years (ranging from 60 to 89 years). Small additional modifications were necessary after the evaluation of the first ten subjects in order to improve comprehension of the test. The final Portuguese version of the ACE-R was produced and was found to be well understood by the remaining 11 subjects, taking an average of 15 minutes to be administered. Conclusions: The Brazilian version of the ACE-R proved to be a promising cognitive instrument for testing both in research and clinical settings. With this regard, additional studies are currently being carried out in our unit in order to investigate the diagnostic properties of the ACE-R in our milieu.
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Pigliautile, Martina, Francesca Chiesi, Franca Stablum, Sonia Rossetti, Caterina Primi, Dora Chiloiro, Stefano Federici, and Patrizia Mecocci. "Italian version and normative data of Addenbrooke's Cognitive Examination III." International Psychogeriatrics 31, no. 2 (July 19, 2018): 241–49. http://dx.doi.org/10.1017/s104161021800073x.
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ABSTRACTObjectives:Addenbrooke's Cognitive Examination III (ACE-III) is a brief cognitive screening tool to assess five cognitive domains: attention/orientation, verbal fluency, memory, language, and visuospatial abilities. This study aimed to provide normative data (for total score and subscale scores) of the Italian version of ACE-III for gender, age, and education.Methods:A total of 574 healthy Italian participants (mean age 68.70 ± 9.65; mean education 9.15 ± 4.04) were recruited from the community and included in the study. Linear regression analysis was performed to evaluate the effects of age, gender, and education on the ACE-III total performance score.Results:Age and education exerted a significant effect on total and subscale ACE-III scores, whereas gender was on attention/orientation, language, and visuospatial subscale scores. From the derived linear equation, correction grids to adjust raw scores and equivalent scores (ESs) with cut-off values were provided.Conclusions:The present study provided normative data, correction grids, and ESs for ACE-III in an Italian population.
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Larner, A. J. "Mini-Addenbrooke's cognitive examination diagnostic accuracy for dementia: reproducibility study." International Journal of Geriatric Psychiatry 30, no. 10 (September 16, 2015): 1103–4. http://dx.doi.org/10.1002/gps.4334.
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Woodford, H. J., and J. George. "Addenbrooke's Cognitive Examination - Revised in day-to-day clinical practice." Age and Ageing 37, no. 3 (March 10, 2008): 350. http://dx.doi.org/10.1093/ageing/afn047.
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Larner, Andrew J., and Alex J. Mitchell. "A meta-analysis of the accuracy of the Addenbrooke's Cognitive Examination (ACE) and the Addenbrooke's Cognitive Examination-Revised (ACE-R) in the detection of dementia." International Psychogeriatrics 26, no. 4 (December 5, 2013): 555–63. http://dx.doi.org/10.1017/s1041610213002329.
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ABSTRACTBackground:The Addenbrooke's Cognitive Examination (ACE) and its Revised version (ACE-R) are relatively new screening tools for cognitive impairment that may improve upon the well-known Mini-Mental State Examination (MMSE) and other brief batteries. We systematically reviewed diagnostic accuracy studies of ACE and ACE-R.Methods:Published studies comparing ACE, ACE-R and MMSE were comprehensively sought and critically appraised. A meta-analysis of suitable studies was conducted.Results:Of 61 possible publications identified, meta-analysis of qualifying studies encompassed 5 for ACE (1,090 participants) and 5 for ACE-R (1156 participants); of these, 9 made direct comparisons with the MMSE. Sensitivity and specificity of the ACE were 96.9% (95% CI = 92.7% to 99.4%) and 77.4% (95% CI = 58.3% to 91.8%); and for the ACE-R were 95.7% (95% CI = 92.2% to 98.2%) and 87.5% (95% CI = 63.8% to 99.4%). In a modest prevalence setting, such as primary care or general hospital settings where the prevalence of dementia may be approximately 25%, overall accuracy of the ACE (0.823) was inferior to ACE-R (0.895) and MMSE (0.882). In high prevalence settings such as memory clinics where the prevalence of dementia may be 50% or higher, overall accuracy again favored ACE-R (0.916) over ACE (0.872) and MMSE (0.895).Conclusions:The ACE-R has somewhat superior diagnostic accuracy to the MMSE while the ACE appears to have inferior accuracy. The ACE-R is recommended in both modest and high prevalence settings. Accuracy of newer versions of the ACE remain to be determined.
Dissertations / Theses on the topic "Addenbrooke's Cognitive Examination"
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Al, Salman Ahmed Saeed Ali. "The Saudi Arabian Adaptation of the Addenbrooke's Cognitive Examination – Revised (Arabic ACE-R)." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4706/.
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BACKROUND: The population of the Arab World is about 300 million and the Arabic language is one of the six official languages of the United Nations. As with the rest of the world, degenerative neurological conditions represent a major health problem in regions such as the Middle-East where Arab people are in the majority. However, clinical neuropsychology is still in its infancy in this region. Very few tools for the assessment of cognition have been developed for use with Arabic speakers in the Middle-East region. The Addenbrooke's Cognitive Examination – Revised is a brief cognitive assessment tool that has been well validated in its original English version as well as a number of other languages, but never been adapted for use with Arabic speakers. An important issue for the assessment of cognition in this region is the high level of illiteracy, particularly in older adults, making the development of tools that can be used with both literate and illiterate participants a priority. OBJECTIVES: The studies presented in this thesis involved the translation, adaptation and validation of an Arabic Addenbrookes Cognitive Examination- Revised (ACE-R) and involved data collection from both literate and iliterate participants. METHODS: The ACE-R was translated into Arabic and the process is described in Chapter 2. Critical to the process was the cultural adaption of the test items. Three parallel versions were developed. Data was collected from four participant samples, recruited in Riyadh, Saudi Arabia: (1) Healthy literate (N= 147); (2) Healthy illiterate (N= 283); (3) Literate with a diagnosis of Alzheimer’s disease (AD) or Mild Cognitive Impairment (MCI) (N= 54); (4) Illiterate with a diagnosis of AD or MCI (N= 169). Chapter 3 presents a study of the validity of the Arabic ACE-R in literate participants. Receiver operating curve (ROC) analyses were undertaken to determine the sensitivity and specificity of the Arabic ACE-R to MCI/dementia, as well as positive and negative predictive values. Optimal cut-off scores were determined. Chapter 4 presents a study of the reliability of the Arabic ACE-R with literate participants. Parallel forms of the Arabic ACE-R were administered on two occasions separated by approximately one week. Test-retest and internal reliability (Cronbach’s alpha) were examined. A version of the test was developed for use with non-literate participants and Chapter 5 presents a study of its validity with this population. Chapter 6 reports a study of the reliability of the tool with non-literate participants. Chapter 7 reports normative data for the Arabic ACE-R, identifying fifth percentile cut-off points. RESULTS: Literate participants: Amongst healthy controls Arabic ACE-R data were not normally distributed, hence non-parametric statistics used in analyses. Amongst healthy controls age was correlated with Arabic ACE-R performance (rho = -0.568, p<0.0001) and level of education was also correlated with Arabic ACE-R performance (rho = 0.559, p<0.0001). As there was a significant difference in age between healthy controls and patient groups, groups were matched for age by removal of young controls and participants also examined in three age bands. Groups were matched for level of education. There were significant differences between each of the three groups examined – Mild Cognitive Impairment, Dementia of the Alzheimer’s type and healthy controls. As the MCI group was small, Receiver Operating Curve (ROC) analyses were conducted on the combined MCI/DAT group compared with the healthy control group. Levels of sensitivity/specificity were high. For a cut-off point of 70, sensitivity was 1.000 and specificity was 0.946. The positive and negative predictive values (PPV and NPV) were also high, particular for base rates that are likely to be closer to those found in clinical practice. For literate participants, internal reliability was high (Cronbach’s alpha, 0.932) as was total score test-retest reliability (rho=0.944). Individual subscale reliability ranged from rho=0.685 (Fluency) to rho=0.865 (Memory). Illiterate participants: Amongst healthy controls Arabic ACE-R data was not normally distributed, hence non-parametric statistics were used again. Amongst healthy controls age was correlated with Arabic ACE-R performance (rho = -286, p<0.001). As there was a significant difference in age between healthy controls and patient groups, groups were matched for age by removal of young controls and participants were also examined in three age bands. At a group level the data showed that there was a significant difference going from healthy to MCI and from MCI to DAT groups. ROC analyses showed that the Arabic ACE-R distinguished well between the healthy controls and patients with a diagnosis of either MCI or DAT. The optimum cut-off point on the Arabic ACE-R (65) had good sensitivity and specificity. Internal reliability was also high (Cronbach’s alpha, 0.987) as was total score test-retest reliability (rho=0.916), with individual sub-scale scores ranging from rho=0.647 (Language) to 0.861 (visuo-spatial). Analysis of normative data indicated the cut-off scores based on fifth percentile point results in somewhat higher cut-off points that those derived from ROC analyses, particularly for the younger literate participants. Potential reasons for these differences are discussed. CONCLUSION: The Arabic ACE-R shows good sensitivity and specificity in the detection of patients with a clinical diagnosis of either AD or MCI. This appears to be the case for both literate and illiterate participants. The Arabic ACE-R (Illiterate version) was straightforward to administer with just four tasks being omitted. This study only compared healthy controls and patients with clear evidence of dementia/MCI (and only small numbers of MCI). Because of the strong tradition of caring for older adults within families, and stigma associated with mental health problems, people with dementia are typically not referred to a doctor until the condition appears very clearly. Further research is needed to examine participants in earlier stages of disease and also participants with psychological/mood disorder. The Arabic ACE-R appears to be a reliable instrument for the assessment of cognitive impairment that may be arising from a degenerative neurological condition for both literate and illiterate participants.
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Morris, Katie J. "The validity of the Addenbrooke's Cognitive Examination-Revised (ACE-R) in acute stroke." Thesis, University of Lincoln, 2009. http://eprints.lincoln.ac.uk/17446/.
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Background: The MMSE is commonly used as a screening instrument for cognitive impairment in stroke services. However, recent research has shown that it has poor diagnostic validity for use in this patient population. The purpose of this study was to examine the validity of the ACE-R as an alternative screening measure for use in stroke. Objectives: The first objective was to determine whether the ACE-R is more accurate than the MMSE at detecting overall cognitive impairment in stroke. The second objective was to determine the accuracy of the ACE-R subscales for detecting impairments in specific cognitive domains. Methods: This study had a cross-sectional design. 40 patients were recruited from an inpatient stroke service. They were administered the ACE-R (which includes the MMSE), and a battery of more detailed neuropsychological tests, which served as the ‘gold standard’ for classification of impairment. The diagnostic validity of the ACE-R and MMSE was determined by ROC analysis. Results: Both the MMSE and the ACE-R were found to have inadequate diagnostic validity for the detection of overall cognitive impairment. No cut-scores scores could be identified which yielded test sensitivity of >80% and specificity of >60%. Levels of specificity were particularly poor. The ACE-R subscales showed a similar pattern of performance, indicating inadequate validity for the detection of impairment in specific areas of cognitive functioning. Conclusions: There was no support for the use of the MMSE or the ACE-R when screening for cognitive impairment in acute stroke. Further research should focus on the identification of an alternative measure.
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Crawford, Stephanie. "An investigation of the reliability of the Addenbrooke's Cognitive Examination – revised (ACE-R) : and clinical research portfolio." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/2142/.
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Objectives: The Addenbrooke's Cognitive Examination – Revised (ACE-R) is a dementia screening tool. The objectives of this study were to investigate rater accuracy in scoring the ACE-R in terms of its total and subscale scores and to examine whether scoring accuracy is affected by participant experience of using the ACE-R. Methods: Three filmed vignettes of the ACE-R being administered to older adult actors (mock patients) were used to assess scoring accuracy across multiple raters. The vignettes had a pre-determined ‘true score’. Study participants were required to complete ACE-R scoring sheets for each vignette. Participants were Community Nurses and Trainee Clinical Psychologists. Results: Participant scores were compared with the pre-determined true scores as a means of measuring scoring accuracy. The results indicated that the majority of participant scores were either the same as or within a few points of the true scores. However, when compared to the true scores, participant total scores differed significantly on two out of the three vignettes. Scoring accuracy was lowest for the Memory subscale of the ACE-R. Scoring accuracy issues were also identified for the Visuospatial and Attention and orientation subscales. Individual items which had low scoring accuracy were identified. Discussion: The majority of participants scored the same as or within a few points of the true scores, such deviation is likely to be clinically acceptable, providing over-emphasis is not placed on cut off scores. Professionals using the ACE-R should ensure they are familiar with the scoring guidelines for the items highlighted in this study as having low scoring accuracy.
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Young, Louise. "Predictive capacity of a cognitive screen : can the Addenbrooke's Cognitive Examination-III predict early relapse following inpatient detoxification in severe alcohol dependence?" Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/15932.
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Background: Alcohol misuse and dependency are major health problems worldwide. Despite the availability of a number of evidence-based treatments for alcohol-dependency, a large proportion of people relapse following detoxification. The costs to society and the individual are vast, not only economically but in terms of social and interpersonal functioning also. There is a recognised need to understand the factors that contribute to poorer outcomes in this population. Cognitive impairment is one factor that has demonstrated considerable associations with poor outcomes in the wider substance-misuse population. Aims: This thesis has two sections. The first comprises a systematic review which aimed to present the objective evidence for emotional decision-making deficits in the alcohol dependent population. The second is an empirical study which aimed to establish whether or not relapse can be predicted in a severely alcohol dependent population in the early stages following inpatient detoxification. In addition, a normative dataset for this clinical population using the ACE-III is presented. Methods: For the systematic review, a structured search of the literature relating to emotional decision-making in alcohol dependent samples was conducted. Iterative application of pre-defined inclusion and exclusion criteria identified eighteen studies for critical review. Quality assessment of these studies was undertaken and validated by means of calculating inter-rater reliability. For the empirical study, two sub-samples of a cross-sectional group of patients being treated for severe alcohol-dependence were examined; one to collate normative data for the ACE-III (N=73) and one to investigate associations between the ACE-III and relapse (N=20), including covariates of age, mood, anxiety and motivation. Results: The systematic review demonstrated substantial support for a deficit in emotional decision-making ability in alcohol-dependence. Methodological quality of the reviewed papers was moderate to high. Deficits in performance on a task of emotional decision-making compared to healthy controls indicated a reduced learning curve in alcohol dependent samples. Limitations of the studies included failure to report power analyses and effect sizes, insufficient detail regarding methodology and exclusion of common comorbidities in alcohol-dependence. The empirical study demonstrated clinically significant cognitive impairment in a sample of severely alcohol dependent individuals in the early stages following detoxification. In a smaller sample, cognitive functioning was not found to be predictive of relapse at one-month post-detoxification. Associations were identified between age and ACE-III score and between age and relapse status. Age was not predictive of outcome. Conclusions: The available evidence points towards the existence of emotional decision-making deficits in alcohol dependent individuals. These are likely to impact on the ability of individuals make the health behaviour changes required to recover from alcohol dependence. Further research may be helpful in identifying factors associated with increased decision-making deficit in this specific population and investigating the processes underlying such difficulties. The clinical normative dataset presented in the empirical study points towards generalised cognitive impairment during the early stages of abstinence which may negatively impact on ability to engage meaningfully with psychosocial interventions. Performance on the ACE-III was not found to predict relapse in the current sample. Previous research would suggest that the links between cognitive functioning and relapse are less well defined in alcohol-misusing samples than in the wider substance-misuse population. Therefore future research may help to clarify this association in alcohol dependent samples. It is acknowledged that the ACE-III is yet to be validated for use in the alcohol dependent population and is limited in its ability to assess executive functions. Given the high prevalence of executive functioning deficits in the alcohol dependent population, it seems of importance to use cognitive screening tools which place appropriate emphasis on these abilities. Service providers are encouraged to incorporate routine cognitive screening into clinical practice and consider the implications of cognitive impairment at both individual and service delivery levels.
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Schöll, Elvira [Verfasser], Alexander [Akademischer Betreuer] Kurz, and Johann [Akademischer Betreuer] Förstl. "Validierung des deutschen Addenbrooke's Cognitive Examination-Revised (ACE-R) / Elvira Schöll. Gutachter: Alexander Kurz ; Johann Förstl. Betreuer: Alexander Kurz." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1033403105/34.
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McGuire, Claire. "An investigation into the utility of the Mini Addenbrooke's Cognitive Examination (M-ACE) for the early detection of dementia and mild cognitive impairment in people aged 75 and over." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7746/.
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Background/Aims: The Mini Addenbrooke’s Cognitive Examination (M-ACE) is the abbreviated version of the widely-used Addenbrooke’s Cognitive Examination (ACE-III), a cognitive screening tool that is used internationally in the assessment of mild cognitive impairment (MCI) and dementia. The objectives of this study were to investigate the diagnostic accuracy of the M-ACE with individuals aged 75 and over to distinguish between those who do and do not have a dementia or MCI, and also to establish whether the cut-off scores recommended by Hsieh et al. (2014) [9] in the original validation study for the M-ACE are optimal for this age group. Methods: The M-ACE was administered to 58 participants (24 with a diagnosis of dementia, 17 with a diagnosis of MCI and 17 healthy controls). The extent to which scores distinguished between groups (dementia, MCI or no diagnosis) was explored using receiver operating characteristic curve analysis. Results: The optimal cut-off for detecting dementia was ≤ 21/30 (score ≤ 21/30 indicating dementia with a sensitivity of 0.95, a specificity of 1 and a positive predictive value of 1) compared to the original higher published cut-off of ≤ 25/30 (sensitivity of 0.95, specificity of 0.70 and a positive predictive value of 0.82 in this sample). Conclusions: The M-ACE has excellent diagnostic accuracy for the detection of dementia in a UK clinical sample. It may be necessary to consider lower cut-offs than those given in the original validation study.
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Carvalho, Viviane Amaral. "Addenbrooke\'s Cognitive Examination - Revised (ACE-R): adaptação transcultural, dados normativos de idosos cognitivamente saudáveis e de aplicabilidade como instrumento de avaliação cognitiva breve para pacientes com doença de Al." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-09122009-153803/.
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INTRODUÇÃO: A Addenbrookes Cognitive Examination Revised (ACE-R) avalia cinco domínios cognitivos em conjunto e também oferece notas parciais para cada um deles, a saber: Atenção e Orientação, Memória, Fluência, Linguagem e Habilidades VisuaisEspaciais. Essa bateria tem se mostrado útil na diferenciação entre a doença de Alzheimer (DA) e a demência frontotemporal (DFT) em outros países. O instrumento foi submetido à adaptação para o português e sua versão brasileira foi previamente publicada pelos autores. OBJETIVO: Investigar o desempenho de indivíduos idosos cognitivamente saudáveis e de outros com DA provável leve na versão brasileira da ACE-R. MÉTODOS: O teste foi administrado a um grupo de 31 pacientes com DA provável leve e a 114 idosos cognitivamente saudáveis. Destes, 62 foram equiparados aos pacientes por idade e escolaridade. Todos os participantes incluídos tinham idade 60 anos e 4 anos de escolaridade. Não apresentavam sintomatologia depressiva associada, definida como pontuação > 7 na Escala Cornell para Depressão em Demência. O comprometimento cognitivo dos pacientes foi evidenciado por pontuação < 123 na Escala Mattis de Avaliação de Demência (DRS). Os controles apresentaram escore total na DRS 123. Dados normativos foram extraídos da amostra total de indivíduos sadios. Foi analisada a correlação entre a ACE-R e o Teste de Memória de Figuras (BCB-Edu), os de Fluência Verbal (Frutas e F.A.S.) e a Bateria de Avaliação Frontal. Os grupos/variáveis foram analisados pelos testes Qui-quadrado, Teste t de Student e Teste de Mann-Whitney. Analisou-se a influência da idade/escolaridade pelo ANOVA e Bonferroni (dados com distribuição normal) e pelo Teste de Kruskal- Wallis e Método Diferença Mínima Significativa (dados sem distribuição normal). Os índices de correlação de Pearson e Spearman foram utilizados para aferir a relação entre o desempenho na ACE-R e nos demais testes cognitivos. A acurácia da bateria foi investigada pela análise das áreas das curvas ROC. RESULTADOS: As médias (DP) de idade e escolaridade dos 62 controles foram de 77,82 (6,58) e 10,05 (4,98), e dos pacientes, 78,03 (6,74) e 9,97 (5,19), respectivamente. A amostra sadia foi subdividida em três faixas etárias (60-69, 70-79 e 80) e em três grupos de escolaridade (4-7, 8-11 e 12). As subescalas da ACE-R se correlacionaram significativamente com os demais testes. Os escores gerais da bateria e da DRS mostraram forte correlação A escolaridade influenciou em todos os escores da ACER. Já a idade interferiu nas subescalas Memória, Fluência e na pontuação total. A nota de corte < 78 na ACE-R demonstrou sensibilidade de 100% e especificidade de 82,26% para o diagnóstico de DA leve (ASC = 0,947). A nota de corte para DA determinada pela razão VLOM foi de > 3,22 (ASC = 0,836; sens. 67,74%; espec. 96,77% e VPP 91,73%). CONCLUSÕES: A versão brasileira da ACE-R provou ser um instrumento de boa acurácia e de propriedades diagnósticas satisfatórias para a avaliação cognitiva em nosso meio, tendo sido capaz de discriminar pacientes com DA leve de indivíduos controles, além de avaliar com eficiência vários domínios cognitivos comumente afetados em estágios iniciais da doença. Os dados normativos apresentados representam parâmetros úteis de normalidade em idosos brasileiros.INTRODUCTION: The Addenbrooke\'s Cognitive Examination Revised (ACE-R) allows evaluation of five cognitive domains, namely: Attention and Orientation, Memory, Fluency, Language and Visuospatial. It is particularly useful in differentiating Alzheimer\'s disease (AD) from frontotemporal dementia (FTD). The instrument was adapted to the Brazilian population and this version has already been published by the authors. OBJECTIVES: To investigate the performance of healthy individuals and patients with mild probable AD in the ACE-R Brazilian version. METHODS: The test was administered to 31 AD patients and to 114 cognitively preserved elderly. Sixty two subjects of this healthy group were adequately matched to the patients for age and education. The participants included were aged 60 years, had 4 years of schooling and did not show depressive symptoms, defined by a score > 7 in the Cornell Scale for Depression in Dementia. Cognitive impairment was defined by a score < 123 in the Mattis Dementia Rating Scale (DRS), while control scores were 123 in the DRS. Normative data were extracted from the whole sample of healthy subjects. We correlated scores in the ACE-R with those in Memory tests from the BCB-Edu, with Verbal Fluency Tests (Fruits and F.A.S.) and with the Frontal Assessment Battery. Data were analyzed with Chi-square test, Students t test and Mann-Whitney test. The influence of age/educational level in ACE-R scores was investigated by ANOVA and Bonferroni Multiple test (normal distribution data) as well as by Kruskal-Wallis test and the Minimum Significant Difference test (non-normal distribution data). Pearsons and Spearmans correlation indexes were used to assess the relationship between performance in the ACE-R and other cognitive tests. The accuracy of the battery was investigated by ROC curve analysis. RESULTS: Mean (SD) age / schooling found in the groups were 77.82 (6.58) / 10.05 (4.98) for the 62 controls and 78.03 (6.74) / 9.97 (5.19) for the patients, respectively. The healthy sample of 114 subjects was divided into three age groups (60-69, 70-79 and 80 years) and into three groups according to education (4-7, 8-11 and 12 years). The performance in the ACE-R subscales significantly correlated with that in the other cognitive instruments. The total scores from both ACE-R and DRS were strongly correlated between themselves. The educational status influenced the ACE-R sub-scores. Age interfered in the Memory, Fluency and in the ACE-R composite score. The cut-off point < 78 of ACE-R demonstrated 100% of sensitivity and 82.26% of specificity for the diagnosis of mild AD (AUC = 0,947). The VLOM cut-off point to determinate AD was > 3.22 (AUC = 0.836; sens. 67.74%; spec. 96.77% and PPV 91.73%). CONCLUSIONS: The Brazilian version of the ACE-R displayed high accuracy and great diagnostic properties for cognitive assessment in our milieu; also it was able to discriminate patients with mild AD from cognitively healthy individuals. In addition, the ACE-R efficiently assesses multiple cognitive domains that are commonly affected in the early stages of dementia. Normative data presented here represent useful parameters for the clinical use of the ACE-R in Brazilian elderly.
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Lennie, Susan. "An investigation into the use of the Addenbrooke's Cognitive Examination-Revised (ACE-R) as a means of predicting rehabilitation outcomes in adults aged 16 or over." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3658/.
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Objectives: To investigate (1) the use of the ACE-R in predicting functional gain during inpatient rehabilitation, and (2) whether ACE-R scores identify patients who will require additional therapy support during their rehabilitation. Design: Prospective cohort study. Setting: UK inpatient physically disabled rehabilitation unit. Participants: Of the 100 adult participants approached, 65 had baseline assessments. Complete data sets were available for 60 (92.3%) participants and included for analysis. Mean age was 49.847 yrs (SD=12.01. Main Outcome measures: Functional gain during rehabilitation was measured using the Functional Independence Measure (FIM). To control for baseline ability, the FIM change (FIM Discharge – FIM admission) was used as the main outcome measure. Results: There were no significant correlations between ACE-R total (rho=.104, P=0.43), Memory (rho=.02, p=0.89) or Fluency (rho=.15, p=0.25) scores and FIM change. There were no significant correlations between FIM change and MMSE, mood, age, medical co-morbidities, number of medications, medication type, gender, continence and catheterisation, or social deprivation. There was a significant difference in the ACE-R Total (p<0.014), Memory (p=0.039) and Fluency (p=0.012) scores between those who did and did not require additional therapy support. A significant difference was also found between men and women in their ACE-R scores and need for additional support. Only ACE-R fluency and gender survived Logistic Regression Analysis. Conclusion: ACE-R scores were not predictive of FIM change scores. The tool appeared more sensitive in identifying patients who required additional support with ACE-R fluency and gender appearing to be independent predictors. The study may have been underpowered to detect significant associations.
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Miranda, Diane da Costa. "Mini-addenbrookes cognitive examination (M-ACE) como instrumento de avaliação cognitiva breve no comprometimento cognitivo leve e doença de Alzheimer leve." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-28092018-082520/.
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INTRODUÇÃO: A Mini-Addenbrooke\'s Cognitive Examination (M-ACE) consiste em um teste de avaliação cognitiva breve composta de cinco itens que visam avaliar quatro domínios cognitivos principais (orientação, memória, linguagem e função viso-espacial) com pontuação máxima de 30 pontos e um tempo de administração de cinco minutos. OBJETIVO: Avaliar o desempenho de idosos cognitivamente saudáveis, com CCL e DA leve na versão brasileira da M-ACE. MÉTODOS: o teste foi aplicado um grupo de 23 pacientes com DA provável leve, 36 CCL e 25 idosos cognitivamente saudáveis. Todos os participantes incluídos tinham idade >= 60 anos. Foram excluídos pacientes com demência de intensidade moderada ou grave, demência de outra etiologia, comorbidades graves com potencial de comprometer a cognição e uso de medicação psicotrópica. A acurácia do teste foi avaliada por meio da análise das curvas ROC. Para analisar a relação entre os escores da M-ACE e os demais testes cognitivos aplicados foram utilizados os coeficientes de correlação de Spearman. Para analisar a consistência interna da M-ACE e suas três versões foi utilizado o coeficiente alfa de Cronbach. RESULTADOS: Houve um predomínio do gênero feminino, a média de idade foi de 73 anos, com faixa etária predominante de 60-69 anos. A média de escolaridade obtida foi de 11 anos. A M-ACE apresentou alta consistência interna (alfa de Cronbach > 0,8; IC 95% 0,776 a 0,869) e mostrou ser extremamente capaz de diferenciar o grupo DA dos demais participantes, com uma acurácia superior ao MEEM. O ponto de corte de 20 foi o de maior sensibilidade e especificidade (95,6% e 90,16% respectivamente), com área sob a curva considerada alta (ASC = 0,805; IC 95% 0,705 -0,904). A M-ACE apresentou melhor precisão em diferenciar os três grupos quando comparado com o MEEM (71,43 versus 60,71). Observou-se ainda uma precisão mais robusta em diferenciar DA de CCL com a M-ACE (63,89 versus 30,56 no MEEM). O escore total da M-ACE não sofreu considerável influência da idade e escolaridade. A M-ACE apresentou forte correlação com MEEM (cor = 0,78), bem como todos os itens (exceto percepção) da BBRC e QAF (cor = -0,76). CONCLUSÃO: A M-ACE pode ser considerada um teste rápido de rastreio com elevada acurácia no diagnóstico de DA. O ponto de corte sugerido neste estudo é de 20 para DA e 27 para CCLINTRODUCTION: The Mini-Addenbrooke\'s Cognitive Examination (M-ACE) consists of a brief cognitive assessment test composed of five items that aim to evaluate four main cognitive domains (orientation, memory, language and visuospatial function) with a maximum score of 30 points and a time of administration of five minutes. OBJECTIVE: Evaluate the performance of cognitively healthy elderly, MCI and mild AD in the Brazilian version of M-ACE. METHODS: The test was applied to a group of 23 patients with mild probable AD, 36 MCI and 25 cognitively healthy elderly. All included participants were aged >= 60 years. Patients with moderate or severe dementia, dementia of another etiology, severe comorbidities with potential to compromise cognition and use of psychotropic medication were excluded. The accuracy of the test was evaluated by analyzing the ROC curves. Spearman\'s correlation coefficients were used to analyze the relationship between the M-ACE scores and the other cognitive tests applied. In order to analyze the internal consistency of the M-ACE, the Cronbach\'s alpha coefficient was used. RESULTS: There was a predominance of females, mean age was 73 years, with a predominant age range of 60-69 years. The average level of schooling was 11 years. MACE presented high internal consistency (Cronbach\'s alpha > 0.8, 95% CI 0.776 to 0.869) and showed to be extremely capable of differentiating the AD group from the other participants, with a higher accuracy than the MMSE. The cutoff point of 20 was the one with the highest sensitivity and specificity (95.6% and 90.16%, respectively), with an AUC considered to be high (AUC = 0.805, 95% CI 0.705-0.904). The M-ACE presented better accuracy in differentiating the three groups when compared to the MMSE (71.43 versus 60.71). It was also observed a more robust precision in differentiating DA of MCI with M-ACE (63.89 versus 30.56 in MMSE). The total M-ACE score was not very influenced by age and schooling. M-ACE showed a strong correlation with MMSE (spearman = 0.78), as well as all items (except perception) of BBRC and QAF (spearman = -0.76). CONCLUSIONS: M-ACE can be considered a brief screening tool with high accuracy in the diagnosis of AD. The cutoff point suggested in this study is 20 for AD and 27 for MCI
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Macdonald, Sarah. "Variables associated with cognitive impairment in adults who misuse alcohol as assessed by the Addenbrooke’s Cognitive Examination (revised)." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3609/.
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Background:The Addenbrooke’s Cognitive Examination-Revised (ACE-R) is a widely used screening tool for Dementia. Although it is recommended for use in detecting cognitive impairment in people who misuse alcohol (Scottish Government 2007), the ACE-R has not been validated with this population. This study compared the performance of a group of people who misuse alcohol on the ACE-R with published normative data. The study examines whether deficits in ACE-R performance are associated with previous experience of a withdrawal from alcohol, duration of alcohol use and units consumed per week. Methods:Data from 77 attendees at the Alcohol Liaison Service in NHS Ayrshire and Arran who had completed the ACE-R was extracted from an existing database and included in the study. The ALS group ACE-R total and domain scores were compared to those of the original validation control group used by Mioshi et al (2006). Using independent t–tests, differences in overall ACE-R performance and domain performance were examined. Independent t-tests were also used to determine the impact of previous withdrawal on ACE-R scores. Correlation analyses and multiple regression were used to examine relationships between aspects of drinking history (previous withdrawal, duration of use and units consumed per week) and ACE-R outcome. Results:Total ACE-R scores, memory and fluency domain scores were significantly lower in the ALS group compared to normative data (p<0.001) It was not possible compare attention, language and visuospatial domain scores between groups as parametric assumptions were not met and only mean control group data was available. Attendees with a history of alcohol withdrawal had significantly poorer scores on the domain of attention compared to those who had not (p=0.009). They appeared to have lower overall ACE-R scores although this differnce was not significant (p=0.128). This analysis was underpowered. Longer duration of alcohol drinking was associated with lower verbal fluency (r=-0.362), lower memory (r=-0.239) and lower visuospatial (rs=-0.234) domain scores. Units consumed weekly were not significantly associated with any ACE-R domain score or total score. Longer duration of alcohol use and previous withdrawal experience together accounted for 10% of the variance in ACE-R total scores (p=0.02). Conclusion:It is likely that most people who chronically and hazardously misuse alcohol will experience persisting cognitive impairment. The ACE-R appears to be a good measure for the assessment such difficulties in this population. This study suggests that it is not possible to accurately judge the severity of cognitive impairment in people who drink hazardously on the basis of duration of alcohol use and previous withdrawal experience alone. The study has methodological limitations and more rigorous research examining the use of the ACE-R with this population is necessary.
Books on the topic "Addenbrooke's Cognitive Examination"
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Hodges, John R. Cognitive Assessment for Clinicians. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780192629760.001.0001.
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This resource aims to incorporate the enormous advances over the last decade in our understanding of cognitive function into clinical practice, particularly the aspects of memory, language and attention. These advances in theory provide a practical approach to cognitive valuation at the bedside, based on methods developed at the Cambridge clinic over the past 15 years. Designed primarily for neurologists, psychiatrists and geriatricians in training who require a practical guide to assessing higher mental function, the resource will also be of interest to clinical psychologists. In this second edition, John Hodges has substantially re-organised and expanded on the original edition. It includes a new chapter devoted to the Revised Version of the Addenbrooke's Cognitive Examination (ACE-R), with a description of its uses and limitations along with normative data. Given the importance of the early detection of dementia, a chapter is dedicated to this topic that draws on advances over the past decade. Several new illustrative case histories have also been added and all of the case descriptions have been orientated around the use of the ACE-R in clinical practice.
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Hodges, John R. The Addenbrooke’s Cognitive Examination—Revised and Supplementary Test Suggestions. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780192629760.003.0007.
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Chapter 7 describes the use of the revised version of the Addenbrooke’s Cognitive Examination: ACE-R. The original test was developed in our clinics in the 1990s and was shown to be sensitive to early Alzheimer’s disease (AD) and to differentiate AD from frontotemporal dementia (FTD). This chapter also describes the ACE-R together with scoring criteria and normative data followed by suggestions for ‘add-on’ bedside tasks that test areas not well covered by the ACE-R.
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Hodges, John R. The Addenbrooke’s Cognitive Examination: Revised and Supplementary Test Suggestions. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198749189.003.0007.
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This chapter discusses the use of the third version of the Addenbrooke’s Cognitive Examination, ACE-III, which has evolved from the early ACE via the ACE-R. The major difference between the ACE-III and earlier versions is the removal of the MMSE which was previously incorporated within the longer test. The chapter describes the ACE-III in full together with scoring criteria and normative data. The ACE-III is freely available and can be downloaded from http://www.ftdrg.org. It has been translated into over 20 languages and is in widespread use in cognitive clinics around the world. The section on the ACE-III is followed by suggestions for ‘add-on’ bedside tasks that test areas not well covered by the ACE-III, such as tests for remote memory, frontal executive function, language, calculation, praxis, neglect phenomena, and complex visuoperceptual abilities and prosopagnosia.
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Owen, Gareth, Sir Simon Wessely, and Sir Simon Wessely, eds. The mental state examination. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199661701.003.0004.
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The chapter outlines traditional categories used to capture the current condition of a patient’s state of mind such as appearance and behaviour, mood, speech, thought content, abnormal beliefs and experiences. It suggests questions to ask and how to organize the material. The chapter encourages a descriptive approach in which examples from the interview are recorded to help future reference and help other clinicians make judgements as to significance. Guidance is also given on examining the cognitive state and interpreting intelligence. Further advice is offered on examining the mental state in the elderly, particularly interpreting cognitive impairment using scales–the Addenbrookes’ Cognitive Examination, the Mini-Mental State Examination, and the Abbreviated Mental Test .
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Hodges, John R. Cognitive Assessment for Clinicians. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198749189.001.0001.
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This book provides clinicians with a theoretically motivated guide to the assessment of patients with cognitive complaints. Its main goal is to teach physicians, psychiatrists, and psychologists how to assess cognition in the clinic or at the bedside based around the instrument, the Addenbrooke’s Cognitive Examination (ACE), developed in Cambridge over many years and subsequently refined and modified. The latest version is the ACE-III, which is freely available and has been translated into many languages. The early chapters provide a framework in which aspects of cognition are considered as those with a distributed representation in the brain (such as attention and memory) versus those with more focal representation (such as language, praxis, and spatial abilities). There are descriptions of the major syndromes encountered in clinical practice, notably delirium and dementia, which have been updated to incorporate recent discoveries. There follows the all-important section on history taking and the ‘meat of the book’: how to perform bedside cognitive testing. The ACE-III is contrasted to other commonly used brief standardized mental test schedules (such as the Montreal Cognitive Examination). Sixteen cases with a full range of cognitive disorders illustrate the method recommended. Finally, there is an appendix outlining the range of formal tests commonly used in neuropsychological practice.
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Hodges, John R. Illustrative Cases. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198749189.003.0008.
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This chapter comprises 16 case histories that illustrate methods of assessment described in the rest of this book and the use of the Addenbrooke’s Cognitive Examination (ACE)-III. Each case begins with a brief history from the patient and observations by the family followed by findings on cognitive examination focusing on the profile shown on the ACE-III, the results of imaging investigations, and a discussion of the diagnosis and its differential, with a final summary of the principal conclusions, indicating whether the services of a neuropsychologist are required or not. The cases present important common conditions (such as mild cognitive impairment, Alzheimer’s disease in the mild and moderate stages, behavioural variant frontotemporal dementia, progressive non-fluent aphasia, semantic dementia, corticobasal degeneration, progressive supranuclear palsy, and Huntington’s disease) as well as interesting neuropsychological syndromes (such as prosopagnosia, amnestic stoke, and transient epileptic amnesia).
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Hodges, John R. Standardized Mental Test Schedules: Their Uses and Abuses. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780192629760.003.0006.
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Chapter 6 discusses various mental test schedules used over the years, from the 10-item Hodgkinson Mental Test, to the much more complex Dementia Rating Scale (DRS. For practical purposes, however, such tests can be divided into two broad groups: (i) the brief schedules that can easily be used in the clinic, or at the bedside, and do not require specialized equipment or training, and (ii) the more elaborate scales, which are used largely, at least at present, in research studies, and require the purchase of test materials and some training in their administration. The Addenbrooke’s Cognitive Examination (ACE) was developed in an attempt to bridge this divide and to provide a test with greater sensitivity to early cognitive decline than the Mini-Mental State Examination (MMSE) and which could also differentiate between different brain diseases. The remainder of this chapter covers possible alternative cognitive screening instruments. It describes three of the most commonly used brief assessment schedules: the MMSE, the Information–Memory–Concentration (IMC) Test, and the 10-item Hodgkinson Mental Test, which is derived from the IMC Test; plus two longer tests, which are widely used in dementia research: the Mattis Dementia Rating Scale (DRS) and the Cambridge Cognitive Examination—Revised (CAMCOG-R). Finally it also includes a description of the Alzheimer’s Disease Assessment Scale (ADAS-Cog) since it has been used widely in drug evaluation studies.
Book chapters on the topic "Addenbrooke's Cognitive Examination"
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Davies, R. Rhys, and Andrew J. Larner. "Addenbrooke’s Cognitive Examination (ACE) and Its Revision (ACE-R)." In Cognitive Screening Instruments, 61–77. London: Springer London, 2012. http://dx.doi.org/10.1007/978-1-4471-2452-8_4.
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Hodges, John R., and Andrew J. Larner. "Addenbrooke’s Cognitive Examinations: ACE, ACE-R, ACE-III, ACEapp, and M-ACE." In Cognitive Screening Instruments, 109–37. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-44775-9_6.
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Matias-Guiu, Jordi A. "Addenbrooke's Cognitive Examination." In Diagnosis and Management in Dementia, 379–93. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-815854-8.00024-0.
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Mioshi, Dawson, Mitchell, Arnold, and Hodges. "Addenbrooke’s Cognitive Examination – Revised (ACE-R)." In A Compendium of Tests, Scales and Questionnaires, 97–105. Psychology Press, 2020. http://dx.doi.org/10.4324/9781003076391-27.
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Burrell, James R., John R. Hodges, and Olivier Piguet. "Neuropsychological assessment of dementia." In Oxford Textbook of Neuropsychiatry, edited by Niruj Agrawal, Rafey Faruqui, and Mayur Bodani, 115–26. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198757139.003.0011.
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Dementia presents itself in many guises, from its more common forms, such as Alzheimer’s disease (AD), vascular dementia (VaD), and dementia with Lewy bodies (DLB), to the less prevalent such as frontotemporal dementia (FTD). Although clinical diagnostic criteria for dementia, such as the DSM-5, do exist, they can be difficult to implement due to the variability of clinical features at presentation of dementia. This chapter provides an insight into the common neuropsychological profiles associated with the symptoms of various forms of dementia, along with overviews of a number of cognitive assessments, from the Mini-Mental State Examination (MMSE) to the Addenbrooke’s Cognitive Examination-III (ACE-III), along with a description of the way each tests for cognitive deficits.
Conference papers on the topic "Addenbrooke's Cognitive Examination"
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Ramachandran, Priya, Kimberly D'Souza, Uma Devaraj, and K. Uma Maheshwari. "Study of cognitive impairment in subjects with obstructive sleep apnoea using Addenbrooke’s Cognitive examination(ACE-R)." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa2541.
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