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Journal articles on the topic "Additional discovery of Mr"

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Verduin, Maikel, Inge Compter, Sergey Primakov, Sander van Kuijk, Maarten te Dorsthorst, Elles Revenich, Mark ter Laan, et al. "NIMG-65. PREDICTING PROGNOSIS AND CANCER HOTSPOT MUTATIONS USING QUALITATIVE MR IMAGING ANALYSIS IN GLIOBLASTOMA." Neuro-Oncology 21, Supplement_6 (November 2019): vi176. http://dx.doi.org/10.1093/neuonc/noz175.734.

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Abstract INTRODUCTION Tumor heterogeneity poses one of the major limitations in improving the treatment for glioblastoma (GBM), which calls for new clinically relevant predictive models. This study aims to investigate non-invasive diagnostic methods, including patient characteristics and qualitative imaging analysis as a prognostic classifier and predictor for druggable oncogenes. METHODS We performed a retrospective analysis on 143 GBM patients (discovery cohort). Diagnostic MRIs were re-analyzed for qualitative imaging features (VASARI features). DNA was extracted from formalin-fixed, paraffin-embedded GBM tissue of the discovery cohort for next-generation sequencing (Ion Torrent Cancer Hotspot panel v2Plus), TERT-promoter mutation and MGMT-methylation analysis. Multivariable regression analysis was used to determine the prognostic and predictive value of VASARI features. RESULTS Of the 143 patients, median age was 61.4 years (range 15.5–84.6) with a median overall survival of 12 months (range 0–142). We observed IDH1 R132H mutation in 8.5%, MGMT-promotor methylation in 26.1%, TERT-promotor mutation (C250T;C228T) in 69.5%, EGFR mutation in 20.3% and EGFR amplification in 37.5% of all patients. A set of eight VASARI features was identified to be associated with overall survival (p< 0.001), which is currently being validated in an external dataset (n= 184). Interestingly, VASARI features appeared to be associated with IDH1-mutation (four features, p=0.004), TERT-promotor mutation (five features, p-value < 0.001), EGFR mutation (five features, p-value < 0.001) and EGFR amplification (seven features, p-value < 0.001) but not with MGMT-methylation (two features, p-value=0.054). Additional cancer hotspots are currently being analyzed and internal validation is ongoing. CONCLUSION AND FUTURE PERSPECTIVES We propose an integrated prognostic classifier comprising MRI features, also associated with GBM-specific molecular alterations. Additionally, quantitative MRI radiomics features are being extracted from the discovery and validation set and incorporated in the prognostic classifier. Subsequently, radiomics and VASARI features will be correlated to intratumoral heterogeneity, assessed by tissue micro-array analysis of the discovery cohort.
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Linehan, Sheena A., Luisa Martínez-Pomares, Philip D. Stahl, and Siamon Gordon. "Mannose Receptor and Its Putative Ligands in Normal Murine Lymphoid and Nonlymphoid Organs: In Situ Expression of Mannose Receptor by Selected Macrophages, Endothelial Cells, Perivascular Microglia, and Mesangial Cells, but not Dendritic Cells." Journal of Experimental Medicine 189, no. 12 (June 21, 1999): 1961–72. http://dx.doi.org/10.1084/jem.189.12.1961.

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The mannose receptor (MR) has established roles in macrophage (Mφ) phagocytosis of microorganisms and endocytic clearance of host-derived glycoproteins, and has recently been implicated in antigen capture by dendritic cells (DCs) in vitro. MR is the founder member of a family of homologous proteins, and its recognition properties differ according to its tissue of origin. Given this heterogeneity and our recent discovery of a soluble form of MR in mouse serum, we studied the sites of synthesis of MR mRNA and expression of MR protein in normal mouse tissues. We demonstrate that synthesis and expression occur at identical sites, and that mature Mφ and endothelium are heterogeneous with respect to MR expression, additionally describing MR on perivascular microglia and glomerular mesangial cells. However, MR was not detected on DCs in situ, or on marginal zone or subcapsular sinus Mφ, both of which have MR-like binding activities. We also compared expression of MR to the binding of a recombinant probe containing the cysteine-rich domain of MR. We show that MR and its putative ligand(s) are expressed at nonoverlapping sites within lymphoid organs, consistent with a transfer function for soluble MR. Therefore, in addition to endocytic and phagocytic roles, MR may play an important role in antigen recognition and transport within lymphoid organs.
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Zhuang, He, Ying Zhang, Shuo Yang, Liang Cheng, and Shu-Lin Liu. "A Mendelian Randomization Study on Infant Length and Type 2 Diabetes Mellitus Risk." Current Gene Therapy 19, no. 4 (November 18, 2019): 224–31. http://dx.doi.org/10.2174/1566523219666190925115535.

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Objective: Infant length (IL) is a positively associated phenotype of type 2 diabetes mellitus (T2DM), but the causal relationship of which is still unclear. Here, we applied a Mendelian randomization (MR) study to explore the causal relationship between IL and T2DM, which has the potential to provide guidance for assessing T2DM activity and T2DM- prevention in young at-risk populations. Materials and Methods: To classify the study, a two-sample MR, using genetic instrumental variables (IVs) to explore the causal effect was applied to test the influence of IL on the risk of T2DM. In this study, MR was carried out on GWAS data using 8 independent IL SNPs as IVs. The pooled odds ratio (OR) of these SNPs was calculated by the inverse-variance weighted method for the assessment of the risk the shorter IL brings to T2DM. Sensitivity validation was conducted to identify the effect of individual SNPs. MR-Egger regression was used to detect pleiotropic bias of IVs. Results: The pooled odds ratio from the IVW method was 1.03 (95% CI 0.89-1.18, P = 0.0785), low intercept was -0.477, P = 0.252, and small fluctuation of ORs ranged from -0.062 ((0.966 - 1.03) / 1.03) to 0.05 ((1.081 - 1.03) / 1.03) in leave-one-out validation. Conclusion: We validated that the shorter IL causes no additional risk to T2DM. The sensitivity analysis and the MR-Egger regression analysis also provided adequate evidence that the above result was not due to any heterogeneity or pleiotropic effect of IVs.
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Polyanskaya, M. V., A. A. Demushkina, F. A. Kostylev, I. G. Vasilyev, V. A. Chadaev, N. N. Zavadenko, and A. A. Alikhanov. "The role of susceptibility-weighted imaging (SWI) in neuroimaging in children with focal epilepsy." Epilepsy and paroxysmal conditions 12, no. 2 (September 11, 2020): 105–16. http://dx.doi.org/10.17749/2077-8333/epi.par.con.2020.025.

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Aim. To approve of diagnostic effectiveness of SWAN (SWI) images in revealing of calcium containing epileptogenic substrates in children with resistant focal epilepsy.Materials and methods. The results of MRI in children with refractory focal epilepsy obtained in the Radiology Department of the Russian State Children Hospital in the period from 2018 to 2020 were observed retrospectively. High-resolution epileptological MR protocol used for investigation of 67 children. SWAN was applied in all cases for identification of calcium containing epileptogenic substrates, including cavernomas, DVA syndrome, cortical gangliogliomas, Sturge-Weber syndrome and tuberous sclerosis complex. All images were received by using MRI 3T 750 W Discovery GE.Results. In 17 cases (25%) SWAN provided important diagnostic information about the nature of the of epileptogenic lesion, its prevalence and borders. Additional earlier invisible structural changes were revealed in 2 cases of SWS and 1 cases of FCD; and in 13 cases SWAN gave us possibility to avoid CT for approving calcium in epileptogenic focus.Conclusion. We believe that adding SWAN in to the epileptological MR protocol is the necessary step for optimizing calcium and blood degradation products identification in the structure of potential epileptogenic focuses. Moreover, it would be very effective instrument for differential diagnosis of cerebral structural changes, specifying its etiology and, hence, would have influence on the therapeutic tactic and surgical strategy in children with focal epilepsy.
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Kotfis, Katarzyna, Kacper Lechowicz, Sylwester Drożdżal, Paulina Niedźwiedzka-Rystwej, Tomasz K. Wojdacz, Ewelina Grywalska, Jowita Biernawska, Magda Wiśniewska, and Miłosz Parczewski. "COVID-19—The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection." Pharmaceuticals 14, no. 1 (January 17, 2021): 71. http://dx.doi.org/10.3390/ph14010071.

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In March 2020, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was declared a global pandemic by the World Health Organization (WHO). The clinical course of the disease is unpredictable but may lead to severe acute respiratory infection (SARI) and pneumonia leading to acute respiratory distress syndrome (ARDS). It has been shown that pulmonary fibrosis may be one of the major long-term complications of COVID-19. In animal models, the use of spironolactone was proven to be an important drug in the prevention of pulmonary fibrosis. Through its dual action as a mineralocorticoid receptor (MR) antagonist and an androgenic inhibitor, spironolactone can provide significant benefits concerning COVID-19 infection. The primary effect of spironolactone in reducing pulmonary edema may also be beneficial in COVID-19 ARDS. Spironolactone is a well-known, widely used and safe anti-hypertensive and antiandrogenic medication. It has potassium-sparing diuretic action by antagonizing mineralocorticoid receptors (MRs). Spironolactone and potassium canrenoate, exerting combined pleiotropic action, may provide a therapeutic benefit to patients with COVID-19 pneumonia through antiandrogen, MR blocking, antifibrotic and anti-hyperinflammatory action. It has been proposed that spironolactone may prevent acute lung injury in COVID-19 infection due to its pleiotropic effects with favorable renin–angiotensin–aldosterone system (RAAS) and ACE2 expression, reduction in transmembrane serine protease 2 (TMPRSS2) activity and antiandrogenic action, and therefore it may prove to act as additional protection for patients at highest risk of severe pneumonia. Future prospective clinical trials are warranted to evaluate its therapeutic potential.
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Hulsey, Josiah, and M. Royhan Gani. "Applying modern interpretation techniques to old hydrocarbon fields to find new reserves: A case study in the onshore Gulf of Mexico, USA." Interpretation 4, no. 4 (November 1, 2016): T637—T655. http://dx.doi.org/10.1190/int-2016-0015.1.

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This study shows how the use of current geological investigative techniques, such as sequence stratigraphy and modern seismic interpretation methods, can potentially discover additional hydrocarbons in old fields that were previously considered depleted. Specifically, we examine the White Castle Field in South Louisiana, which has produced over 84.1 million barrels of oil and 63.1 billion cubic feet of gas but retains additional recoverable hydrocarbons. The field has pay sections ranging from late Oligocene to late Miocene. The upper Oligocene to early Miocene package, which was underexploited and understudied during the previous exploitation phase, contains three primary reservoirs (Cib Haz, MW, and MR). During most of the late Oligocene, the White Castle Salt Dome was located in a minibasin on the continental slope. The Cib Haz and MW reservoirs were deposited in this minibasin and offer great exploitation potential. The Cib Haz interval is an amalgamation of slumped shelfal limestones, sandstones, and shales interpreted to represent a lowstand systems tract (LST). The MW comprises a shelf-edge delta deposit that is also interpreted as part of a LST. The MR reservoir is interpreted as an incised valley fill located in the continental shelf that was deposited during a lowstand of sea level after the minibasin was filled. Finally, it appears that the minibasin acted as a self-contained hydrocarbon system during the late Oligocene, suggesting the possibility of a shale play. In this study, several new areas of interest are revealed that could contain economical amounts of hydrocarbons.
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Sarikaya-Seiwert, Sevgi, Bernd Turowski, Daniel Hänggi, Giesela Janssen, Hans-Jakob Steiger, and Walter Stummer. "Symptomatic intracystic hemorrhage in pineal cysts." Journal of Neurosurgery: Pediatrics 4, no. 2 (August 2009): 130–36. http://dx.doi.org/10.3171/2009.4.peds08309.

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Pineal cysts are benign and often asymptomatic intracranial entities. Occasionally they can lead to neurological symptoms through growth or due to intracystic hemorrhage. The purpose of the current report is to describe their clinical characteristics and treatment options. In the current study, the authors illustrate the course of disease in 3 patients who developed neurological symptoms due to hemorrhage into a pineal cyst. Two of their patients had additional cerebral disease, and regular MR imaging examinations were conducted. This circumstance allowed documentation of growth and intracystic hemorrhage. After the occurrence of new neurological symptoms with severe headache, MR images showed a fluid-fluid interface due to intracystic hemorrhage. The third patient presented with acute triventricular hydrocephalus and papilledema due to aqueductal stenosis caused by intracystic hemorrhage. In all 3 cases, excision of the pineal cysts via an infratentorial/supracerebellar approach was performed. Histological examination revealed the characteristic structure of pineal cyst in all cases, with hemorrhagic residues in the form of hemosiderin deposits. All patients recovered fully after surgical removal of the cysts. Furthermore, resolution of occlusive hydrocephalus could be demonstrated in those cases with ventricular enlargement. Pineal cysts without neurological symptoms are often discovered as incidental findings on cranial MR images. In contrast, neurological symptoms such as severe headache, diplopia, or Parinaud syndrome, may occur as a result of pineal apoplexy due to intracystic hemorrhage. The authors' cases confirm that MR imaging can identify intracystic hemorrhage by a characteristic fluid-fluid interface. Their experience suggests that microsurgical resection of cysts may be an effective and curative treatment option.
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Matías-García, Pamela R., Rory Wilson, Qi Guo, Shaza B. Zaghlool, James M. Eales, Xiaoguang Xu, Fadi J. Charchar, et al. "Plasma Proteomics of Renal Function: A Transethnic Meta-Analysis and Mendelian Randomization Study." Journal of the American Society of Nephrology 32, no. 7 (June 16, 2021): 1747–63. http://dx.doi.org/10.1681/asn.2020071070.

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BackgroundStudies on the relationship between renal function and the human plasma proteome have identified several potential biomarkers. However, investigations have been conducted largely in European populations, and causality of the associations between plasma proteins and kidney function has never been addressed.MethodsA cross-sectional study of 993 plasma proteins among 2882 participants in four studies of European and admixed ancestries (KORA, INTERVAL, HUNT, QMDiab) identified transethnic associations between eGFR/CKD and proteomic biomarkers. For the replicated associations, two-sample bidirectional Mendelian randomization (MR) was used to investigate potential causal relationships. Publicly available datasets and transcriptomic data from independent studies were used to examine the association between gene expression in kidney tissue and eGFR.ResultsIn total, 57 plasma proteins were associated with eGFR, including one novel protein. Of these, 23 were additionally associated with CKD. The strongest inferred causal effect was the positive effect of eGFR on testican-2, in line with the known biological role of this protein and the expression of its protein-coding gene (SPOCK2) in renal tissue. We also observed suggestive evidence of an effect of melanoma inhibitory activity (MIA), carbonic anhydrase III, and cystatin-M on eGFR.ConclusionsIn a discovery-replication setting, we identified 57 proteins transethnically associated with eGFR. The revealed causal relationships are an important stepping stone in establishing testican-2 as a clinically relevant physiological marker of kidney disease progression, and point to additional proteins warranting further investigation.
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Sato, Enos Nobuo, Carlos Teixeira, Beck Nader, and Giorgio de Tomi. "Time Series Models to Obtain the Barrel Crude Oil Prices." Materials Science Forum 805 (September 2014): 422–28. http://dx.doi.org/10.4028/www.scientific.net/msf.805.422.

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The use of time series as an additional tool in decision making for the oil industry has been established as a mechanism for predicting the behavior of crude oil price. Especially in Brazil, after the discovery in this decade of the pre-salt reservoirs, the estimate of the price of a crude oil barrel through the use of modern techniques can minimize risks in exploration and production of oil. The more appropriate pricing for crude oil aims to minimize the risks to the economic activity for both exporters and importers of oil. This paper presents six different methods for obtaining crude oil future pricesi.e.Multiple regression (MR), Holt ́s method (HM), Holt-Winter (HW), Kalman filter (KF), Auto-Regression/Moving-Average (ARIMA) and stochastic simulation based on the use of the Monte Carlo method (SMC). The methods are compared to determine their advantages and disadvantages against each other, seeking to determine which of the generated models has the best potential to determine the future fair price of a barrel of oil. As a result, the most appropriate methodology capable of projecting a more precise future barrel oil fair price was determined, among the six alternatives studied.
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Dicks, Jonathan. "The Roman Villa at Woodham's Farm, Kings Worthy, Hampshire." Hampshire Studies 73, no. 1 (November 1, 2018): 145–55. http://dx.doi.org/10.24202/hs2018006.

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Additional information about the Romano-British villa at Woodham's Farm was discovered whilst researching the villas at Sparsholt and Twyford. Amongst the Sparsholt material held by the late David Johnston was an envelope containing coins from Woodham's Farm. Similarly, amongst the Twyford paper archive held by Martin Biddle was a letter from Mr. W. H. Blake of Woodham's Farm to Lieut. Colonel Montague dated 14th September 1925. The letter briefly described his excavation of the site and contains a sketch of the exposed ground plan of parts of the villa. This short report is based on the information held by Winchester Museum Services (History File ARCH 296). It documents the discoveries found and attempts to put the Romano-British Villa at Woodham's Farm into a regional context.
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Dissertations / Theses on the topic "Additional discovery of Mr"

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Huang, Xiayu. "Discovery of a potential regulatory transcription factor upon redox alterations in Shewanella oneidensis MR-1." 2008. http://purl.galileo.usg.edu/uga%5Fetd/huang%5Fxiayu%5F200808%5Fphd.

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Books on the topic "Additional discovery of Mr"

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Admiralty, Great Britain. Additional papers relative to the arctic expedition under the orders of Captain Austin and Mr. William Penny. London: G.E. Eyre and W. Spottiswoode, 2004.

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Lindroth, Tracey. Mr. Duck's wonderful discovery. Globe, Ariz: Deep End Art Co., 2005.

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Dudgeon, William. The philosophical works: And, Some additional letters to the Revd. Mr. Jackson ; with Mr. Jackson's answers to them. London, England: Routledge/Thoemmes Press, 1994.

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Gallop, Alan. Mr Stanley, I presume?: The life and explorations of Henry Morton Stanley. Thrupp, Stroud, Gloucestershire: Sutton Pub., 2004.

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Dobrée, Pascoe John, and Langton Graham, eds. Mr. Explorer Douglas: John Pascoe's New Zealand classic. Christchurch, N.Z: Canterbury University Press, 2000.

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John, Bailey. Mr. Stuart's track: The forgotten life of Australia's greatest explorer. Sydney [N.S.W.]: Pan Macmillan Australia, 2006.

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Wilkie, Collins. The frozen deep: And, Mr. Wray's cash-box. Stroud, Gloucestershire: A. Sutton Pub., 1996.

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United States. Congress. Senate. Committee on Energy and Natural Resources. Designation of the American Discovery Trail as a study trail: Report together with additional views (to accompany S. 3011). [Washington, D.C.?: U.S. G.P.O., 1992.

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United States. Congress. Senate. Committee on the Judiciary. Mr. Robert Martinez to be director of National Drug Control Policy: Report together with supplemental, additional and minority views (to accompany the nomination of Mr. Bob Martinez to be director of National Drug Control Policy). [Washington, D.C.?: U.S. G.P.O., 1991.

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Silver, S. William. Catalogue of the York Gate Library formed by Mr. S. William Silver: An index to the literature of geography maritime and inland discovery commerce and colonisation. Mansfield Centre, CT: Martino, 2004.

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Book chapters on the topic "Additional discovery of Mr"

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Kroczek, Wacław Jan, and Robert Young. "Validation of 113-Year Old Israel Kristal as the World’s Oldest Man." In Demographic Research Monographs, 285–95. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-49970-9_20.

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AbstractThis book chapter provides a detailed description of the discovery, research, and validation of the case of Mr. Israel Kristal of Israel, 113, as the World’s Oldest Man titleholder for Guinness World Records. In this chapter, we show how modern scientific age validation criteria were applied to prove the credibility of the claims made about Mr. Kristal’s age. Due to the hardships Mr. Kristal faced in his early life, validating his age proved to be extremely difficult. While the first attempts to validate Mr. Kristal’s age were made in early 2014, a breakthrough in these investigative efforts did not occur until January 2016. To validate his age, the Gerontology Research Group contacted not only Mr. Kristal’s family, but also international institutions specializing in genealogical research. A special note of appreciation should go to the Jewish Records Indexing in Poland for their contributions to this investigation. As a result of this international cooperation, sufficient early-life, middle-life, and late-life evidence was obtained to meet modern validation standards. Israel Kristal was finally recognized as the oldest living man in the world on Mar. 11, 2016 (retroactive to Jan. 19, 2016). Israel Kristal is the second validated supercentenarian in the history of Israel, after Dr. Maria Pogonowska (1897–2009), who was also born in Poland. In addition, he is the current longevity record-holder of Israel.
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Artemov, Dmitri, and Zaver M. Bhujwalla. "Novel Imaging Agents for Molecular MR Imaging of Cancer." In Drug Discovery Handbook, 1309–41. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471728780.ch28.

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Ceci, Michelangelo, Annalisa Appice, and Donato Malerba. "Mr-SBC: A Multi-relational Naïve Bayes Classifier." In Knowledge Discovery in Databases: PKDD 2003, 95–106. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-540-39804-2_11.

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Lin, T. Y. "Generating Concept Hierarchies/Networks: Mining Additional Semantics in Relational Data." In Advances in Knowledge Discovery and Data Mining, 174–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/3-540-45357-1_22.

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Wolz, Robin, Paul Aljabar, Joseph V. Hajnal, and Daniel Rueckert. "Manifold Learning for Biomarker Discovery in MR Imaging." In Machine Learning in Medical Imaging, 116–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-15948-0_15.

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Seidl, Thomas, Brigitte Boden, and Sergej Fries. "CC-MR – Finding Connected Components in Huge Graphs with MapReduce." In Machine Learning and Knowledge Discovery in Databases, 458–73. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-33460-3_35.

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Fan, Xian, Jie Yang, and Lishui Cheng. "A Novel Segmentation Method for MR Brain Images Based on Fuzzy Connectedness and FCM." In Fuzzy Systems and Knowledge Discovery, 505–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/11539506_64.

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Sjøvold, Torstein. "A sensational additional discovery at the finding site of the Iceman at Hauslabjoch." In Der Mann im Eis, 115–18. Vienna: Springer Vienna, 1995. http://dx.doi.org/10.1007/978-3-7091-6599-7_10.

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S., Kannan, and Anusuya S. "Detection of Tumor From Brain MRI Images Using Supervised and Unsupervised Methods." In AI Innovation in Medical Imaging Diagnostics, 61–75. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-3092-4.ch003.

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Brain tumor discovery and its segmentation from the magnetic resonance images (MRI) is a difficult task that has convoluted structures that make it hard to section the tumor with MR cerebrum images, different tissues, white issue, gray issue, and cerebrospinal liquid. A mechanized grouping for brain tumor location and division helps the patients for legitimate treatment. Additionally, the method improves the analysis and decreases the indicative time. In the separation of cerebrum tumor, MRI images would focus on the size, shape, area, and surface of MRI images. In this chapter, the authors have focused various supervised and unsupervised clustering techniques for identifying brain tumor and separating it using convolutional neural network (CNN), k-means clustering, fuzzy c-means grouping, and so on.
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"Mr. Yang also Goes to Kiev." In A Passion for Discovery, 87–93. WORLD SCIENTIFIC, 2007. http://dx.doi.org/10.1142/9789812772152_0015.

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Conference papers on the topic "Additional discovery of Mr"

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Nayak, Richi, and Bryan Lee. "Web Service Discovery with additional Semantics and Clustering." In IEEE/WIC/ACM International Conference on Web Intelligence (WI'07). IEEE, 2007. http://dx.doi.org/10.1109/wi.2007.82.

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Wang, Hao, and Haiyan Hu. "The Neuro-fuzzy Identification of MR Damper." In 2009 Sixth International Conference on Fuzzy Systems and Knowledge Discovery. IEEE, 2009. http://dx.doi.org/10.1109/fskd.2009.545.

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Tzacheva, Angelina A., Midhun M. Sunny, and Pranava Mummoju. "MR-Apriori count distribution algorithm for parallel Action Rules discovery." In 2016 IEEE International Conference on Knowledge Engineering and Applications (ICKEA). IEEE, 2016. http://dx.doi.org/10.1109/ickea.2016.7803005.

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Aiach, M., M. Roncato, G. Sorin, P. Dezellus, and J. N. Fiessinger. "A NEW AT III VARIANT WITH DEFECTIVE PROTEASE BINDING SITE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642941.

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A decreased plasma anti thrombin activity in presence heparin cofactor (hep-cof) or in absence of heparin (AT) was discovered in a 47 year-old patient presenting with recurrent venous thromboembolism. The immunoreactive material (AT III-IR) was normal. The same biological abnormalities were found in two relatives of the patient, leading to the diagnosis of hereditary qualitative AT III deficiency.The propositus'AT III was coeluted with normal AT III from an heparin sepharose column. An additional step of ion-exchange chromatography on a Mono Q column using a FPLC system (Pharmacia, Bois d'Arcy, France) allowed the purification of a protein which was homogenous in SDS - 10 % polyacrylamide electrophoresis gel (PAGE). AT III purified from propositus'plasma, normal plasma and the plasma of a patient known to have an AT III variant with defective protease binding (1) were compared. The specific activities measured as hep-cof AT or factor Xa inhibition in absence of heparin (anti Xa) were respectively 6.4 and 4.8 U/mg for the propositus 'AT III and 13.6 and 8.5 U/mg for the normal AT III (one unit is the activity of 1 ml of a plasma pool prepared from 30 normal subjects). The formation of protease inhibitor complexes was studied by incubating purified AT III with purified thrombin (in molar ratio 1:4, 1:2, 1:1) during 5 minutes at 37 °C and submitting the mixture to PAGE. The densitometric scan showed that in equimolar ratio the percentage of an AT III-thrombin complex (with 92 kA Mr) reaches 70 for normal AT III and respectively 30 and 23 for the propositus'AT III and the already described variant AT III Charlevillé (1). A 70 % proportion of free AT III (58 kA) remained for the propositus. As previously observed an unidentified 63 kA compound appeared for AT III Charleville. This results strongly suggest that in the patient described here, half th the AT III molecules are normal, the others having a defective protease binding site. We propose to call this new variant AT III Avranches, the town where the propositus was born.(1) Thrombosis Research 1985, 39, 559-570.
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Ozyurt, Onur, Alp Dincer, and Cengizhan Ozturk. "Brain MR image segmentation with fuzzy C-means and using additional shape elements." In 2009 14th National Biomedical Engineering Meeting. IEEE, 2009. http://dx.doi.org/10.1109/biyomut.2009.5130271.

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Liu, Yi, Cheng Lei, and Hongqi Zhang. "MR-Verifier: Verifying Open Flow Network Properties Based on MapReduce." In 2015 International Conference on Cyber-Enabled Distributed Computing and Knowledge Discovery (CyberC). IEEE, 2015. http://dx.doi.org/10.1109/cyberc.2015.57.

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7

Tsai, Yi-Hsing. "ICL ONVIF Middleware: Additional services on TI Davinci platform." In 2012 9th International Conference on Fuzzy Systems and Knowledge Discovery (FSKD). IEEE, 2012. http://dx.doi.org/10.1109/fskd.2012.6233976.

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8

Anderson, Walter, The Nguyen, and Mohammad Elahinia. "Vibration Mitigation With a Multi-Axial Magnetorheological Mount." In ASME 2009 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2009. http://dx.doi.org/10.1115/smasis2009-1353.

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Abstract:
This paper presents a multi-axial magnetorheological (MMR) mount. An MMR mount has been developed for use with hydraulic hybrid vehicles (HHV). Like hybrid electric vehicles (HEV), HHV provides better fuel economy. An inherent problem to hydraulic hybrid vehicles is vibration of the hydraulic pump-motor (P/M). This vibration can be classified as shock loading for initial start-up, and periodic vibration over a large frequency range. The latter vibration opportunity can be classified as having large displacement at low frequency and small displacement at high frequency. This requires a stiff mount for the low frequency response and a soft mount for the high frequency response. A single axis magnetorheological (MR) mount has previously been developed and studied by the same group. This was done to develop an understanding of the MR fluid and to discover the limitations of such a mount. Models to predict the experimental results have also been generated. These models show a good correlation to the experimental results. Then, the model has been enhanced from the single axis mount to a multi-axial. This was done by examining the 3-D CAD model to develop the different boundary conditions for the simulation. With a multi-axial magnetorheological mount, damping and stiffness can be altered to yield acceptable transmissibility over the frequency range. This is achieved through the use of an inertia track paired with a pseudo-decoupler. These features are commonly found in a passive hydraulic mount; however through the use of MR fluid, the downfalls of the hydraulic mount can be mitigated, e.g. performance deterioration outside of notch frequency. Additionally, a magnetorheological mount is semi-active so there is an inherent stability to the mount. The MMR mount uses elastomer and MR fluid to achieve the static stiffness to support the P/M and achieve low dynamic stiffness for the high frequency response, which is necessary for a good isolator. The advantages of the use of a multi-axial magnetorheological mount are as follows: fewer mounts are required, stability when compared to an active mount, less power required when compared to an active mount, better isolation when compared to pure elastomeric and passive hydraulic mounts. A model for a multi-axial magnetorheological mount has been developed and simulated. For the purposes of this study, elastomer has been considered to have a linear dynamic response. Additionally, the shock response of the mount has not been considered. Future work includes manufacturing a multi-axial MR mount to verify the simulation results.
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Liu, Jing, Lizhong Lu, Bin Yan, and Jian Chen. "A Brain MR Image Segmentation Approach Based on Local Intensity Fitting Curve Evolution." In 2009 Sixth International Conference on Fuzzy Systems and Knowledge Discovery. IEEE, 2009. http://dx.doi.org/10.1109/fskd.2009.363.

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Wang, Shu, Hengshan Wang, and Gang Xiao. "Optimum Multiresolution Fusion Scheme for CT/MR Images Based on Region Feature." In Fourth International Conference on Fuzzy Systems and Knowledge Discovery (FSKD 2007). IEEE, 2007. http://dx.doi.org/10.1109/fskd.2007.438.

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