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Journal articles on the topic 'Additive to bone allografts'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Putzer, David, Johannes Fuchs, Débora Coraça-Huber, Christoph Ammann, Michael Liebensteiner, and Michael Nogler. "BAG-S53P4 as an Additive to Bone Allografts: A Laboratory Study Using an Uniaxial Compression Test." J Orthop Res 33 (June 12, 2015): 1875–79. https://doi.org/10.1002/jor.22953.

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ABSTRACT: We want to address the clinical issue of too sparse supply of allograft in total hip replacement and ambitions of controlling the grain size distribution. Bioglass BAG-S53P4 was evaluated as a bone graft additive to chemically treated allografts with controlled grain size distribution. Allografts were chemically cleaned (CG) and mixed with BAG-S53P4 additive (BG) for comparison. All samples were compacted with a dropped weight apparatus and then underwent a uniaxial compression test. The yield limit was determined by a uniaxial compression test and density was recorded while flowabil

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Coraça-Huber, Débora C., Stephan J. M. Steixner, Stevo Najman, et al. "Lyophilized Human Bone Allograft as an Antibiotic Carrier: An In Vitro and In Vivo Study." Antibiotics 11, no. 7 (2022): 969. http://dx.doi.org/10.3390/antibiotics11070969.

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Background: Antibiotics delivered from implanted bone substitute materials (BSM) can potentially be used to prevent acute infections and biofilm formation, providing high concentrations of antibiotics at the surgical site without systemic toxicity. In addition, BSM should allow osteoconductivity supporting bone healing without further surgery. Promising results have been achieved using lyophilized bone allografts mixed with antibiotics. Methods: In this study specially prepared human bone allografts were evaluated as an antibiotic carrier in vitro and in vivo. The efficacy of different antibio

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Nather, Aziz, Vikram David, Janelle WH Teng, Choon Wei Lee, and Barry P. Pereira. "Effect of Autologous Mesenchymal Stem Cells on Biological Healing of Allografts in Critical-sized Tibial Defects Simulated in Adult Rabbits." Annals of the Academy of Medicine, Singapore 39, no. 8 (2010): 599–606. http://dx.doi.org/10.47102/annals-acadmedsg.v39n8p599.

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Introduction: This study evaluated the effect of autologous bone marrow derived adult Mesenchymal Stem Cells (MSCs) on the biological healing of weight bearing diaphyseal bone allograft in the tibia of adult rabbits. Materials and Methods: Forty Adult New Zealand White Rabbits divided into 3 groups (Autograft, Allograft or Allograft impregnated with MSCs) with 12 rabbits in each group were used for the study. A 1.5 cm of cortical bone segment was excised from the rabbit’s right tibia. The segment was replaced by an Autograft, Allograft or Allograft loaded with MSCs, depending on which group th

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Storb, R., RF Raff, FR Appelbaum, et al. "DLA-identical bone marrow grafts after low-dose total body irradiation: the effect of canine recombinant hematopoietic growth factors." Blood 84, no. 10 (1994): 3558–66. http://dx.doi.org/10.1182/blood.v84.10.3558.3558.

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Abstract Previous studies found that bone marrow (BM) allografts from DLA- identical littermates resulted in survival of two thirds of recipient dogs after otherwise lethal doses of 450 to 600 cGy of total body irradiation (TBI) because of successful allografts or autologous recovery after rejection of the allografts. The current study asked whether survival could be further improved by treating allograft recipients with recombinant canine granulocyte colony-stimulating factor (G-CSF), stem cell factor (SCF), or G-CSF/SCF. Of 21 dogs, 14 (67%) receiving allografts but no growth factors survive

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Storb, R., RF Raff, FR Appelbaum, et al. "DLA-identical bone marrow grafts after low-dose total body irradiation: the effect of canine recombinant hematopoietic growth factors." Blood 84, no. 10 (1994): 3558–66. http://dx.doi.org/10.1182/blood.v84.10.3558.bloodjournal84103558.

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Previous studies found that bone marrow (BM) allografts from DLA- identical littermates resulted in survival of two thirds of recipient dogs after otherwise lethal doses of 450 to 600 cGy of total body irradiation (TBI) because of successful allografts or autologous recovery after rejection of the allografts. The current study asked whether survival could be further improved by treating allograft recipients with recombinant canine granulocyte colony-stimulating factor (G-CSF), stem cell factor (SCF), or G-CSF/SCF. Of 21 dogs, 14 (67%) receiving allografts but no growth factors survived, 10 wit

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Kulyaba, T. A., N. N. Kornilov, A. V. Kazemirskiy, et al. "Double Trabecular Tantalum Cones as an Alternative to Additive Technologies for Revision Knee Arthroplasty (A Case Series)." Traumatology and Orthopedics of Russia 26, no. 2 (2020): 148–59. http://dx.doi.org/10.21823/2311-2905-2020-26-2-148-159.

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Relevance. To compensate the extensive (AORI type III) bone defects, metal cones/ sleeves or massive allografts are used. In the absence of metaepiphyses, structural allografts or megaprostheses are usually used for tumor lesions of the bones. The aim of the study was to show the possibility of replacing extensive type III defects of the femur and tibia, covering the metaphysical and diaphyseal zones, with double tantalum cones.Materials and Methods. The study included 13 patients undergone revision knee arthroplasty in 2015–2019. During the surgery, the primary fixation of the femoral or tibi

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Esfahanian, Vahid, Fatemeh Ejeian, Hajar Mohebinia, et al. "Cellular Behaviors of Periodontal Ligament Stem Cells in the Presence of Bone Grafting Biomaterials, In-Vitro Study." Life 13, no. 1 (2022): 89. http://dx.doi.org/10.3390/life13010089.

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Periodontal regeneration through the employment of bone substitutes has become a feasible strategy in animal and clinical studies. In this regard, we aimed to compare the periodontal ligament stem cell behavior in the vicinity of various bone grafting substitutes. Three types of popular bone substitutes, including allografts (Regen), xenografts (Cerabone), and alloplasts (Osteon) were studied in this experimental survey. The cellular attachment was assessed after four hours using the MTS assay and SEM imaging. In addition, cellular proliferation was investigated after 1, 3, 5, and 7 days throu

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Huddleston, Hailey P., Atsushi Urita, William M. Cregar, et al. "Overlapping Allografts Provide Superior and More Reliable Surface Topography Matching Than Oblong Allografts: A Computer-Simulated Model Study." American Journal of Sports Medicine 49, no. 6 (2021): 1505–11. http://dx.doi.org/10.1177/03635465211003074.

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Background: Osteochondral allograft transplantation is 1 treatment option for focal articular cartilage defects of the knee. Large irregular defects, which can be treated using an oblong allograft or multiple overlapping allografts, increase the procedure’s technical complexity and may provide suboptimal cartilage and subchondral surface matching between donor grafts and recipient sites. Purpose: To quantify and compare cartilage and subchondral surface topography mismatch and cartilage step-off for oblong and overlapping allografts using a 3-dimensional simulation model. Study Design: Control

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9

Bay, Jacques-Olivier, Aurelie Cabrespine-Faugeras, Reza Tabrizi, et al. "Double Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation: French Society of Bone Marrow Graft Transplantation and Cellular Therapy Experience." Blood 112, no. 11 (2008): 4293. http://dx.doi.org/10.1182/blood.v112.11.4293.4293.

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Abstract Purpose: Objective was to assess indication, feasibility and efficacy of double allograft with reduced intensity conditioning. Patients and Methods: All double allogeneic hematopoietic stem cell transplantation (AHSCT) after reduced intensity regimen reported to Promise database were retrospectively studied. Because of the initial lack of clinical and biological data in the Registry, all centers were contacted to improve the database. Results: 66 double mini-allografts were realized in 25 french transplant centers. At this time, 35 mini-allografts presented complete informations corre

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Maletis, Gregory B., Tadashi Ted Funahashi, Rebecca Love, et al. "Demonstrating the Value of an ACL Registry." Orthopaedic Journal of Sports Medicine 6, no. 7_suppl4 (2018): 2325967118S0010. http://dx.doi.org/10.1177/2325967118s00103.

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Objectives: One purpose of a registry is to identify procedures or devices that have either good or poor outcomes and improve treatment outcomes through feedback to surgeons. In 2010 we initially reported the influence of graft choice on the risk of early revision after ACL Reconstruction (ACLR). In 2012 we reported a three times higher risk of revision if allograft was used rather than bone-patellar tendon-bone (BPTB) autograft. In subsequent studies of allografts, we have identified poorer results with BPTB allografts compared to soft tissue allografts and with soft tissue allografts irradia

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Wiratnaya, I. Gede Eka. "PDGF-BB Induces Formation of Bridging Callus After Reconstructive Surgery of Large Bone Defect." Open Orthopaedics Journal 12, no. 1 (2018): 583–94. http://dx.doi.org/10.2174/1874325001812010583.

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Background:Reconstructive surgery by using allografts often conducted to manage large bone defects, either due to traumatic or non-traumatic causes. However, poor vascularization of the graft bed is still problematic. To overcome this, bone tissue engineering method has been developed that uses growth factor as an angiogenic stimulator, such as platelet derived growth factor BB (PDGF BB).Objective:This study aimed to evaluate the administration of recombinant rat Platelet Derived Growth Factor BB (rrPDGF BB) on bone healing process, showed by formation of bridging callus, Vascular Endothelial

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Benady, Amit, Noy Yehiel, Ortal Segal, et al. "Knee-Sparing Resection and Reconstruction Surgery for Bone Sarcoma Using 3D-Surgical Approach: Average of 5-Year Follow-Up." Medicina 61, no. 3 (2025): 476. https://doi.org/10.3390/medicina61030476.

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Background and Objectives: To date, the gold standard of care for bone sarcomas is limb salvage surgical resection. In cases where the tumor arises in the distal femur or proximal tibia near the joint line, knee-sacrificing surgery is typically performed, followed by reconstruction with oncological megaprostheses. This study aims to evaluate the effectiveness of a precise 3D-based surgical approach for knee-sparing tumor resections, assessing its feasibility and its impact on surgical, oncological, and functional outcomes. Materials and Methods: This single-center retrospective study presents

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Danilkowicz, Richard M., Nicholas B. Allen, Nate Grimm, et al. "Histological and Inflammatory Cytokine Analysis of Osteochondral Lesions of the Talus After Failed Microfracture: Comparison With Fresh Allograft Controls." Orthopaedic Journal of Sports Medicine 9, no. 10 (2021): 232596712110405. http://dx.doi.org/10.1177/23259671211040535.

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Background: The most common first-line treatment of osteochondral lesions of the talus (OLTs) is microfracture. Although many patients do well with this procedure, a number fail and require reoperation. The mechanism of failure of microfracture is unknown, and to our knowledge there has been no research characterizing failed microfracture regarding histological and inflammatory makeup of these lesions that may contribute to failure. Purpose: To characterize the structural and biochemical makeup of failed microfracture lesions. Study Design: Case series; Level of evidence, 4. Methods: Specimens

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Seung, Edward, Neal Iwakoshi, Bruce A. Woda, et al. "Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice." Blood 95, no. 6 (2000): 2175–82. http://dx.doi.org/10.1182/blood.v95.6.2175.

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Abstract We describe a tolerance-based stem cell transplantation protocol that combines sublethal radiation with transient blockade of the CD40-CD154 costimulatory pathway using an anti-CD154 antibody. With this protocol, we established hematopoietic chimerism in BALB/c mice transplanted with fully allogeneic C57BL/6 bone marrow. The percentage of donor-origin mononuclear cells in recipients was more than 99%. In addition, all chimeric mice treated with anti-CD154 antibody remained free of graft-versus-host disease (GVHD) and accepted donor-origin but not third-party skin allografts. It was si

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Putzer, David, Markus Dobersberger, Alex Pizzini, Debora Coraça-Huber, Christoph Ammann, and Michael Nogler. "Platelet concentrate as an additive to bone allografts: a laboratory study using an uniaxial compression test." Cell and Tissue Banking 19, no. 4 (2018): 559–67. http://dx.doi.org/10.1007/s10561-018-9704-3.

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David, Putzer, Fuchs Johannes, Coraça-Huber Débora, Christoph Ammann, Liebensteiner Michael, and Nogler Michael. "BAG-S53P4 as an additive to bone allografts: A laboratory study using an uniaxial compression test." Journal of Orthopaedic Research 33, no. 12 (2015): 1875–79. http://dx.doi.org/10.1002/jor.22953.

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17

Nadershah, Mohammed M., Yaser A. Alsahafi, Raghad A. Alyahyawi, et al. "Saudi population preferences for type of bone substitutes a cross-sectional study, Saudi Arabia." Saudi Journal of Oral Sciences 11, no. 3 (2024): 222–33. https://doi.org/10.4103/sjoralsci.sjoralsci_57_24.

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Abstract Introduction: The benefits of using bone grafts have been known for half a century. Bone grafting is defined as a surgical procedure that involves the transplantation of bone to repair a deficit or missing bone tissue. These bone substitutes can be classified into several main categories depending on their source. Aims: The purpose of this research is to inspect the Saudi population’s preferences and opinions regarding different types of bone graft materials. Materials and Methods: A cross-sectional survey based on a structured questionnaire in the Arabic language includes demographic

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Alkhelaifi, Khalid, Osama Z. Alzobi, Shady A. Mahmoud, and Bashir A. Zikria. "Recurrent Instability After the Latarjet Procedure." Journal of the American Academy of Orthopaedic Surgeons 33, no. 1 (2025): e60-e60. https://doi.org/10.5435/jaaos-d-24-01477.

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The Latarjet procedure is a favored approach for managing chronic and recurrent dislocation, especially in the presence of bone loss. Although generally yielding excellent results, the procedure carries a 15 to 30% complication rate. Although recurrent instability is a major concern, various complications such as infection, nerve injuries, and hardware impingement can also necessitate revision after a Latarjet procedure. Strategies for addressing this issue include glenoid bone grafting, using autogenous bone grafts from the iliac crest or distal clavicle, and allografts, with fresh lateral di

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Brown, John A., Robert H. Brophy, John Franco, et al. "Avoiding Allograft Length Mismatch during Anterior Cruciate Ligament Reconstruction." American Journal of Sports Medicine 35, no. 6 (2007): 986–89. http://dx.doi.org/10.1177/0363546506298584.

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Background Given the increasing use of allografts in anterior cruciate ligament reconstruction, selection of appropriate-sized grafts may help individual surgeons as well as the efficiency of the overall system for graft distribution. Hypothesis Recipient patient height can predict the desired length for the tendinous portion of a patellar bone-tendon-bone allograft in anterior cruciate ligament reconstruction. Study Design Cohort study (Prognosis); Level of evidence, 2. Methods A series of 414 knees in 392 consecutive patients undergoing magnetic resonance imaging evaluation of knee pain were

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Lu, L., W. A. Rudert, S. Qian, et al. "Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor." Journal of Experimental Medicine 182, no. 2 (1995): 379–87. http://dx.doi.org/10.1084/jem.182.2.379.

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Allografts of the liver, which has a comparatively heavy leukocyte content compared with other vascularized organs, are accepted permanently across major histocompatibility complex barriers in many murine strain combinations without immunosuppressive therapy. It has been postulated that this inherent tolerogenicity of the liver may be a consequence of the migration and perpetuation within host lymphoid tissues of potentially tolerogenic donor-derived ("chimeric") leukocytes, in particular, the precursors of chimeric dendritic cells (DC). In this study, we have used granulocyte/macrophage colon

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Sigrist, Bastian, Stephen Ferguson, Elisabeth Boehm, Christian Jung, Markus Scheibel, and Philipp Moroder. "The Biomechanical Effect of Bone Grafting and Bone Graft Remodeling in Patients With Anterior Shoulder Instability." American Journal of Sports Medicine 48, no. 8 (2020): 1857–64. http://dx.doi.org/10.1177/0363546520919958.

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Background: Individual constitutional differences in glenoid shape and bone remodeling require a patient-specific and longitudinal approach to evaluate the biomechanical effects of glenoid bone grafting in patients with anterior shoulder instability. Purpose: To quantify the longitudinal, in vivo, biomechanical effects of bone grafting, bone graft remodeling, and glenoid shape in patients with anterior shoulder instability by means of patient-specific finite element models. Study Design: Descriptive laboratory study. Methods: In total, 25 shoulders of 24 patients with anterior shoulder instabi

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Jeppsson, Charlotte, Jörgen Åstrand, Magnus Tägil, and Per Aspenberg. "A combination of bisphosphonate and BMP additives in impacted bone allografts." Acta Orthopaedica Scandinavica 74, no. 4 (2003): 483–89. http://dx.doi.org/10.1080/00016470310017839.

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SM, Harsini. "Bone Regenerative Medicine and Bone Grafting." Open Access Journal of Veterinary Science & Research 3, no. 4 (2018): 1–7. http://dx.doi.org/10.23880/oajvsr-16000167.

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Bone tissues can repair and regenerate it: in many clinical cases, bone fractures repair without scar formation. Nevertheless, in large bone defects and pathological fractures, bone healing fail to heal. Bone grafting is defined as implantation of material which promot es fracture healing, through osteoconduction osteogenesis, and osteoinduction. Ideal bone grafting depends on several factors such as defect size, ethical issues, biomechanical characteristics, tissue viability, shape and volume, associated complications, cost, graft size, graft handling, and biological characteristics. The mate

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Percival, Kelly M., Vinod Paul, and Ghaleb A. Husseini. "Recent Advancements in Bone Tissue Engineering: Integrating Smart Scaffold Technologies and Bio-Responsive Systems for Enhanced Regeneration." International Journal of Molecular Sciences 25, no. 11 (2024): 6012. http://dx.doi.org/10.3390/ijms25116012.

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In exploring the challenges of bone repair and regeneration, this review evaluates the potential of bone tissue engineering (BTE) as a viable alternative to traditional methods, such as autografts and allografts. Key developments in biomaterials and scaffold fabrication techniques, such as additive manufacturing and cell and bioactive molecule-laden scaffolds, are discussed, along with the integration of bio-responsive scaffolds, which can respond to physical and chemical stimuli. These advancements collectively aim to mimic the natural microenvironment of bone, thereby enhancing osteogenesis

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Tuleubaev, Berik. "The use of bone grafts in combination with additive technologies in orthopedic practices." Traumatology and Orthopаedics of Kazakhstan 76, no. 2 (2025): 12–19. https://doi.org/10.52889/1684-9280-2025-2-76-12-19.

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The issue of selecting a material for bone reconstruction in orthopaedic surgery remains relevant and continues to evolve in tandem with technological advancements. This review aims to analyze one relatively novel aspect of orthopedics, namely, the combined use of bone grafts with 3D technology.A literature search was conducted using modern actual European and American medical data bases. All search results were filtered by language and period of 2014-2024. There were more then 10000 articles by keywords and after exclusion remained 10 articles. For analyzing cohort studies we used Coleman Met

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Evrard, R., L. Maistriaux, J. Manon, et al. "MASSIVE BONE ALLOGRAFT DECELLULARIZATION BY A PERFUSION PROTOCOL SET UP FOR A BIOCOMPATIBLE MODEL." Orthopaedic Proceedings 105-B, SUPP_7 (2023): 40. http://dx.doi.org/10.1302/1358-992x.2023.7.040.

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The purpose of this study is to enhance massive bone allografts osseointegration used to reconstruct large bone defects. These allografts show >50% complication rate requiring surgical revision in 20% cases. A new protocol for total bone decellularisation exploiting the vasculature can offer a reduction of postoperative complication by annihilating immune response and improving cellular colonization/ osseointegration.The nutrient artery of 18 porcine bones - humerus/femur/radius/ulna - was cannulated. The decellularization process involved immersion and sequential perfusion with specific so

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Łuczak, Julia Weronika, Małgorzata Palusińska, Damian Matak, et al. "The Future of Bone Repair: Emerging Technologies and Biomaterials in Bone Regeneration." International Journal of Molecular Sciences 25, no. 23 (2024): 12766. http://dx.doi.org/10.3390/ijms252312766.

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Bone defects and fractures present significant clinical challenges, particularly in orthopedic and maxillofacial applications. While minor bone defects may be capable of healing naturally, those of a critical size necessitate intervention through the use of implants or grafts. The utilization of traditional methodologies, encompassing autografts and allografts, is constrained by several factors. These include the potential for donor site morbidity, the restricted availability of suitable donors, and the possibility of immune rejection. This has prompted extensive research in the field of bone

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Raziuddin, Arati, Dan L. Longo, Llewellyn Mason, John R. Ortaldo, Michael Bennett, and William J. Murphy. "Differential Effects of the Rejection of Bone Marrow Allografts by the Depletion of Activating Versus Inhibiting Ly-49 Natural Killer Cell Subsets." Journal of Immunology 160, no. 1 (1998): 87–94. http://dx.doi.org/10.4049/jimmunol.160.1.87.

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Abstract Natural killer cells mediate the specific rejection of bone marrow cell (BMC) allografts in lethally irradiated mice. The Ly-49 family of molecules present on subsets of murine NK cells appears capable of binding class I MHC molecules, resulting in transmission of an inhibitory signal to the NK cell. These Ly-49 family members have been shown to have an immunoreceptor tyrosine-based inhibitory motif that is responsible for the inhibitory signal. However, a new Ly-49 family member was found that lacks this motif, Ly-49D, and evidence suggests that this may be an activating receptor. We

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Ziaee, Mohsen, Rebecca Hershman, Ayesha Mahmood, and Nathan B. Crane. "Fabrication of Demineralized Bone Matrix/Polycaprolactone Composites Using Large Area Projection Sintering (LAPS)." Journal of Manufacturing and Materials Processing 3, no. 2 (2019): 30. http://dx.doi.org/10.3390/jmmp3020030.

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Cadaveric decellularized bone tissue is utilized as an allograft in many musculoskeletal surgical procedures. Typically, the allograft acts as a scaffold to guide tissue regeneration with superior biocompatibility relative to synthetic scaffolds. Traditionally these scaffolds are machined into the required dimensions and shapes. However, the geometrical simplicity and, in some cases, limited dimensions of the donated tissue restrict the use of allograft scaffolds. This could be overcome by additive manufacturing using granulated bone that is both decellularized and demineralized. In this study

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Arner, Justin W., and Robert D. Santrock. "A Historical Review of Common Bone Graft Materials in Foot and Ankle Surgery." Foot & Ankle Specialist 7, no. 2 (2014): 143–51. http://dx.doi.org/10.1177/1938640013516358.

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Foot and ankle fusion is an important treatment for arthritis and deformities of the ankle and hindfoot. The literature has shown that there are improvements in fusion rates with the addition of bone graft and bone graft substitutes. Today autografts, specifically the iliac crest bone graft (ICBG), continue to be the gold standard despite significant donor site morbidity and nonunion rates, persisting around 10%. To address these drawbacks, bone graft substitutes have been developed. This article includes a historical review of the use, outcomes, and safety of autografts, allografts, and bone

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Tashmetov, E., D. Saginova, Y. Kamyshanskiy, A. Saginov, and A. Koshanova. "THERMALLY DISINFECTED HUMAN FEMORAL HEAD AS SCAFFOLD FOR OSTEOINDUCTIVE SUBSTANCES." Orthopaedic Proceedings 106-B, SUPP_2 (2024): 84. http://dx.doi.org/10.1302/1358-992x.2024.2.084.

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Various approaches have been implemented to enhance bone regeneration, including the utilization of autologous platelet-rich plasma and bone morphogenetic protein-2. The objective of this study was to evaluate the impact of Marburg Bone Bank-derived bone grafts in conjunction with platelet-rich plasma (PRP), recombinant human bone morphogenetic protein-2 (rhBMP-2), and zoledronic acid (ZA) on osteogenesis within rabbit bone defects.MethodologyBone defects (5mm in diameter) were created in the femurs of 96 male rabbits. The animals were allocated into five groups: (1) bone graft + PRP (BG + PRP

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Cohn-Schwartz, Doron, Yeshai Schary, Eran Yalon, et al. "PTH-Induced Bone Regeneration and Vascular Modulation Are Both Dependent on Endothelial Signaling." Cells 11, no. 5 (2022): 897. http://dx.doi.org/10.3390/cells11050897.

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The use of a bone allograft presents a promising approach for healing nonunion fractures. We have previously reported that parathyroid hormone (PTH) therapy induced allograft integration while modulating angiogenesis at the allograft proximity. Here, we hypothesize that PTH-induced vascular modulation and the osteogenic effect of PTH are both dependent on endothelial PTH receptor-1 (PTHR1) signaling. To evaluate our hypothesis, we used multiple transgenic mouse lines, and their wild-type counterparts as a control. In addition to endothelial-specific PTHR1 knock-out mice, we used mice in which

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Schätzlein, Eva, Christoph Kicker, Nicolas Söhling, et al. "3D-Printed PLA-Bioglass Scaffolds with Controllable Calcium Release and MSC Adhesion for Bone Tissue Engineering." Polymers 14, no. 12 (2022): 2389. http://dx.doi.org/10.3390/polym14122389.

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Large bone defects are commonly treated by replacement with auto- and allografts, which have substantial drawbacks including limited supply, donor site morbidity, and possible tissue rejection. This study aimed to improve bone defect treatment using a custom-made filament for tissue engineering scaffolds. The filament consists of biodegradable polylactide acid (PLA) and a varying amount (up to 20%) of osteoconductive S53P4 bioglass. By employing an innovative, additive manufacturing technique, scaffolds with optimized physico-mechanical and biological properties were produced. The scaffolds fe

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Huang, Zengfa, Cheng Cheng, Jing Wang, et al. "Surface Properties and MC3T3-E1 Cell Response of Cortical Bone Allografts Modified with Low-Concentration Phosphoric Acid." Cellular Physiology and Biochemistry 41, no. 4 (2017): 1572–83. http://dx.doi.org/10.1159/000470823.

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Background/Aims: This experimental study aimed to evaluate the effect of low-concentration phosphoric acid on the surface structure of cortical allografts. Methods: Allogenic cortical bones were obtained from femurs and tibias of New Zealand white rabbits. The bones were modified by treatment with various concentrations of phosphoric acid (10%, 20% or 30%) for 10, 30 or 60 minutes, then evaluated by the following methods: 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and LIVE/DEAD assay, alkaline phosphatase (ALP) assay, biomechanical properties testing, contact angle

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FULLARTON, A. C., M. A. GLASBY, and G. M. LAWSON. "Immediate and Delayed Nerve Repair Using Freeze-Thawed Muscle Allografts." Journal of Hand Surgery 23, no. 3 (1998): 360–64. http://dx.doi.org/10.1016/s0266-7681(98)80058-2.

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Six sheep underwent repair of the median nerve in the forearm using freeze-thawed muscle autografts, along with the establishment and repair of a “fracture” adjacent to the site of nerve injury. The “fracture” was created by making a transverse osteotomy of the radius. It was repaired using an 8-hole dynamic compression plate. A further six sheep underwent similar treatment with the repair of the nerve delayed for 30 days after the establishment of the long-bone injury. Six months after the nerve repair, each group of sheep was assessed using electrophysiological and morphometric methods in or

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Mora, G., J. R. Valenti, and A. Valenti. "P26 Effect of the addition of growth factors in the results of ACL reconstructions with bone-tendon-bone allografts." Osteoarthritis and Cartilage 15 (2007): B94. http://dx.doi.org/10.1016/s1063-4584(07)61381-8.

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Bhushan, Sakchi, Sandhya Singh, Tushar Kanti Maiti, et al. "Scaffold Fabrication Techniques of Biomaterials for Bone Tissue Engineering: A Critical Review." Bioengineering 9, no. 12 (2022): 728. http://dx.doi.org/10.3390/bioengineering9120728.

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Bone tissue engineering (BTE) is a promising alternative to repair bone defects using biomaterial scaffolds, cells, and growth factors to attain satisfactory outcomes. This review targets the fabrication of bone scaffolds, such as the conventional and electrohydrodynamic techniques, for the treatment of bone defects as an alternative to autograft, allograft, and xenograft sources. Additionally, the modern approaches to fabricating bone constructs by additive manufacturing, injection molding, microsphere-based sintering, and 4D printing techniques, providing a favorable environment for bone reg

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Nicolae, Carmen-Larisa, Diana-Cristina Pîrvulescu, Adelina-Gabriela Niculescu, et al. "An Up-to-Date Review of Materials Science Advances in Bone Grafting for Oral and Maxillofacial Pathology." Materials 17, no. 19 (2024): 4782. http://dx.doi.org/10.3390/ma17194782.

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Bone grafting in oral and maxillofacial surgery has evolved significantly due to developments in materials science, offering innovative alternatives for the repair of bone defects. A few grafts are currently used in clinical settings, including autografts, xenografts, and allografts. However, despite their benefits, they have some challenges, such as limited availability, the possibility of disease transmission, and lack of personalization for the defect. Synthetic bone grafts have gained attention since they have the potential to overcome these limitations. Moreover, new technologies like nan

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Chivu, Manuela, Cristian Tantar, Emilian Hutu, Raluca Monica Comaneanu, and Elena Rusu. "Evaluation of Bone Healing of Artificial Defects in Laboratory Animals After Covering with Alloplastic Material." Revista de Chimie 69, no. 7 (2018): 1728–32. http://dx.doi.org/10.37358/rc.18.7.6405.

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Bone defects are commonly seen in clinical practice. They are caused by different types of trauma, infections, congenital malformations and cancers. Current approaches to skeletal reconstructive surgery use biomaterials, autografts or allografts. The aim of this study was to analyze bone repair from histologic point of view. To study the repair of bone defects, we used two batches of Wistar mices (Lat Rattus Norvegicus). The 46 subjects under study were divided into two equal lots. In all subjects, a round defect with a diameter of 5 mm was surgically performed on the right and left parietal b

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Lau, Chau Sang, Jasper Chua, Somasundaram Prasadh, Jing Lim, Leonardo Saigo, and Bee Tin Goh. "Alveolar Ridge Augmentation with a Novel Combination of 3D-Printed Scaffolds and Adipose-Derived Mesenchymal Stem Cells—A Pilot Study in Pigs." Biomedicines 11, no. 8 (2023): 2274. http://dx.doi.org/10.3390/biomedicines11082274.

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Alveolar ridge augmentation is an important dental procedure to increase the volume of bone tissue in the alveolar ridge before the installation of a dental implant. To meet the high demand for bone grafts for alveolar ridge augmentation and to overcome the limitations of autogenous bone, allografts, and xenografts, researchers are developing bone grafts from synthetic materials using novel fabrication techniques such as 3D printing. To improve the clinical performance of synthetic bone grafts, stem cells with osteogenic differentiation capability can be loaded into the grafts. In this pilot s

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Bowland, Philippa, Eileen Ingham, John Fisher, and Louise M. Jennings. "Simple geometry tribological study of osteochondral graft implantation in the knee." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 232, no. 3 (2018): 249–56. http://dx.doi.org/10.1177/0954411917751560.

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Robust preclinical test methods involving tribological simulations are required to investigate and understand the tribological function of osteochondral repair interventions in natural knee tissues. The aim of this study was to investigate the effects of osteochondral allograft implantation on the local tribology (friction, surface damage, wear and deformation) of the tissues in the natural knee joint using a simple geometry, reciprocating pin-on-plate friction simulator. In addition, the study aimed to assess the ability of osteochondral grafts to restore a low surface damage, deformation and

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William, Joshua, Mahamudu Mtebwa, Regina Mtei, and Innocent Macha. "3D Printed Composite Structures for Bone Repair and Drug Delivery Application." Tanzania Journal of Engineering and Technology 42, no. 1 (2023): 1–17. http://dx.doi.org/10.52339/tjet.v42i1.884.

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Due to the increase in traffic accidents, industrial contingencies, and natural disasters, there is a high demand for bone regeneration biomaterials. Although bone can regenerate and self-repair, it is difficult to do so when the defect area exceeds the critical repair area due to trauma, tumour resection, or congenital diseases. The traditional methods for bone repair are autograft, allograft, and xenograft. However, these methods have flaws and limitations, such as complications in the donor bone area, a limited number of donors, rejection, and infectious diseases. However, in recent years,

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Yazid, Bello, Haruna Lukman, Yakubu Abdulrahman, et al. "Current Trends in Transplantation of Patients with Hematological Malignancies." INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND BIO-MEDICAL SCIENCE 03, no. 02 (2023): 57–79. https://doi.org/10.5281/zenodo.7623713.

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Hematopoietic stem cell transplantation (HSCT) is widely used to treat hematological malignancies and nonmalignant hematological disorders. Many advances have been made in improving the success of bone marrow transplantation. However, lack of available matched related or matched sibling donors has posed a significant challenges to the availability and proper utilization of hematopoietic stem cell transplantation in patients with hematological malignancies. The rising availability of alternative donors, particularly haploidentical donors (HIDs), has propelled the rapid rise of allo-HSCT.&n

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Alshirah, Akram. "EFFECT OF DIFFERENT GRAFTING MATERIALS ON ALVEOLAR RIDGE PRESERVATION." International Journal of Advanced Research 11, no. 03 (2023): 1112–29. http://dx.doi.org/10.21474/ijar01/16542.

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Objectives: The purpose of this systematic review was to assess the effect of several grafting materials on alveolar bone resorption after teeth extraction. Materials & methods: Electronic literature searches in MEDLINE (PubMed) and Cochrane (CENTRAL) were performed, in addition to a manual search through all periodontics and implantology-related journals, for publications in the period from January 1st, 2009, to February 1st, 2021. The primary focus was related to studies comparing alveolar ridge preservation reporting quantitative outcomes of hard tissue changes. Results: In total,18 ran

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Zhang, Zhu-Xu, Ye Su, Xuyan Huang, et al. "Establishment of nonmyeloablative bone marrow chimerism by double negative Treg cells through inducing T cell clonal deletion and suppressing NK cell function (126.1)." Journal of Immunology 188, no. 1_Supplement (2012): 126.1. http://dx.doi.org/10.4049/jimmunol.188.supp.126.1.

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Abstract In bone marrow transplantation, T cells and NK cells play important role for graft rejection. In addition, graft-versus-host-disease and establishment of stable chimeric states without complete marrow ablation remain as major obstacles post bone marrow transplantation. In this study, we aimed to establish mixed chimerism in a non-irradiation condition. Our data indicate that adoptive transfer of donor-derived TCRαβ+CD3+CD4-CD8-NK1.1-(double negative, DN) Treg cells prior to C57BL/6 to BALB/c bone marrow transplantation, in combination with cyclophosphamide but not cyclosporine, FK506,

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Porta, Marta, Chiara Tonda-Turo, Daniele Pierantozzi, Gianluca Ciardelli, and Elena Mancuso. "Towards 3D Multi-Layer Scaffolds for Periodontal Tissue Engineering Applications: Addressing Manufacturing and Architectural Challenges." Polymers 12, no. 10 (2020): 2233. http://dx.doi.org/10.3390/polym12102233.

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Reduced periodontal support, deriving from chronic inflammatory conditions, such as periodontitis, is one of the main causes of tooth loss. The use of dental implants for the replacement of missing teeth has attracted growing interest as a standard procedure in clinical practice. However, adequate bone volume and soft tissue augmentation at the site of the implant are important prerequisites for successful implant positioning as well as proper functional and aesthetic reconstruction of patients. Three-dimensional (3D) scaffolds have greatly contributed to solve most of the challenges that trad

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Byregowda, Suman, Ajay Puri, and Ashish Gulia. "Topical vancomycin: Does it reduce surgical site infection in bone tumors?" South Asian Journal of Cancer 06, no. 03 (2017): 099–101. http://dx.doi.org/10.4103/2278-330x.214572.

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Abstract Introduction: We retrospectively analyzed a consecutive group of patients operated for bone tumors of extremity and pelvis who received only perioperative antibiotics (Group A) against a similar group that had additional 1 g topical vancomycin sprinkled in the wound before closure (Group B). The aim was to determine if the addition of topical vancomycin decreases the incidence of deep surgical site infection (SSI). Materials and Methods: A total of 221 patients operated between January 2011 and December 2011 were analyzed in Group A and 254 patients operated between April 2012 and Mar

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Wagner, John E., Mary Eapen, Margaret L. MacMillan, et al. "Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia." Blood 109, no. 5 (2006): 2256–62. http://dx.doi.org/10.1182/blood-2006-07-036657.

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AbstractBone marrow transplantation (BMT) is the only known cure for the hematologic manifestations of Fanconi anemia (FA). Potential benefits of unrelated donor BMT for FA, however, have been severely limited by graft rejection and treatment-related mortality with resultant poor survival. Therefore, we evaluated the impact of potential prognostic factors on hematopoietic recovery, graft-versus-host disease (GVHD), and mortality in 98 recipients of unrelated donor BMT who received transplants between 1990 and 2003. Probabilities of neutrophil (89% vs 69%; P = .02) and platelet (74% vs 23%; P &

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Rahyussalim, Ahmad Jabir, Dina Aprilya, Raden Handidwiono, Yudan Whulanza, Ghiska Ramahdita, and Tri Kurniawati. "The Use of 3D Polylactic Acid Scaffolds with Hydroxyapatite/Alginate Composite Injection and Mesenchymal Stem Cells as Laminoplasty Spacers in Rabbits." Polymers 14, no. 16 (2022): 3292. http://dx.doi.org/10.3390/polym14163292.

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Several types of laminoplasty spacer have been used to fill bone gaps and maintain a widened canal. A 3D scaffold can be used as an alternative spacer to minimize the risk observed in allografts or autografts. This study aims to evaluate the in vivo biocompatibility and tissue–scaffold integration of a polylactic acid (PLA) scaffold with the addition of alginate/hydroxyapatite (HA) and mesenchymal stem cell (MSc) injections. This is an experimental study with a pretest and post-test control group design. A total of 15 laminoplasty rabbit models were divided into five groups with variations in

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Lei, Shuangyan, Matthew C. Frank, Donald D. Anderson, and Thomas D. Brown. "A method to represent heterogeneous materials for rapid prototyping: the Matryoshka approach." Rapid Prototyping Journal 20, no. 5 (2014): 390–402. http://dx.doi.org/10.1108/rpj-10-2012-0095.

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Purpose – The purpose of this paper is to present a new method for representing heterogeneous materials using nested STL shells, based, in particular, on the density distributions of human bones. Design/methodology/approach – Nested STL shells, called Matryoshka models, are described, based on their namesake Russian nesting dolls. In this approach, polygonal models, such as STL shells, are “stacked” inside one another to represent different material regions. The Matryoshka model addresses the challenge of representing different densities and different types of bone when reverse engineering fro

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