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Dissertations / Theses on the topic 'Adenine Methyltransferase'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

McKelvie, Jennifer C. "Novel antibiotics from DNA adenine methyltransferase inhibitors." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/341769/.

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The re-emergence of plague as a world-wide health concern and the potential risk posed by bioterrorism has led to an increased interest in available treatments for the disease. The bacterial DNA adenine-N6 methyltransferase, Dam, is involved in the regulation of a range of pathogenic bacteria and has been validated as a target for the development of antimicrobial agents with activity against Yersinia pestis, the causative agent of plague. The lack of a functionally similar enzyme in mammals suggests that highly selective Dam inhibitors could be developed. A coupled, real-time break light Dam a

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2

Maynard-Smith, Michael David. "Novel antibiotics from DNA adenine methyltransferase inhibitors." Thesis, University of Southampton, 2009. https://eprints.soton.ac.uk/202481/.

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DNA adenine methylation plays a role in several core bacterial processes, including DNA mismatch repair, the timing of DNA replication and gene expression. The dependence of bacterial virulence on the activity of Dam, an adenine methyltransferase, makes it an attractive target for novel antibiotics. Dam from Yersinia pestis, the plague causing bacteria, was expressed and purified by nickel affinity chromatography. A plasmid containing the methylation sensitive restriction endonuclease dpnI gene was assembled. DpnI was expressed and purified by nickel affinity chromatography. A Y. pestis Dam ac

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3

Riaz, Faysal Kayani. "The application of mutant DNA adenine methyltransferase enzymes in Dam indentification." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611459.

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4

Bonnist, Eleanor Y. M. "The investigation of DNA-methyltransferase interactions in the adenine methyltransferases using the time-resolved fluorescence of 2-aminopurine." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/3175.

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The time-resolved fluorescence of 2-aminopurine (2AP) has been used to investigate DNA base flipping by the adenine methyltransferases and to study aspects of the DNA-enzyme interaction. 2AP is an excellent fluorophore to probe base flipping in the adenine methyltransferases because, as demonstrated in the present work on M.TaqI, the 2AP is delivered into the same position inside the enzyme as the natural target adenine and with the same orientation that prepares the adenine for enzyme catalysis. 2AP emits two types of fluorescence when in DNA. The first is the well-known 370-nm emission, whic

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5

Harmer, Jennifer. "Antibiotic discovery and development using structural analysis of DNA adenine methyltransferase inhibitors." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/366964/.

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The requirement for developing antibiotics is continually increasing due to the rise in antibiotic resistance and lack of novel compounds that bypass the known resistance mechanisms. A well-characterised target for such development is DNA adenine methyltransferase (Dam), a suitable candidate because it is connected with virulence in a number of highly pathogenic bacteria as well as the lack of a human equivalent enabling selectivity. A fluorescence-based activity assay has been developed to identify potential Dam inhibitors, which then require structural analysis to confirm mode of binding and

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6

Kuehn, Joanna Sue. "Dam methylation and putative fimbriae in Klebsiella pneumoniae." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/391.

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DNA adenine methyltransferase (Dam) plays an important role in different bacterial functions. It has been shown that Dam is required for regulation of bacterial replication initiation and is required for proofreading newly synthesized DNA through methylation directed mismatch repair. Dam is also involved in the regulation of different genes and is required for virulence in several different bacterial genera though its degree of importance depends on the specific bacteria being studied. During this work, a Dam-negative strain (JSM1) was constructed in Klebsiella pneumoniae strain 43816 to ascer

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7

Kuehn, Joanna Sue Clegg Steven. "Dam methylation and putative fimbriae in Klebsiella pneumoniae." Iowa City : University of Iowa, 2009. http://ir.uiowa.edu/etd/391.

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8

Albu, Razvan Florin [Verfasser]. "An analysis of structural and biochemical aspects of the bacterial DNA adenine-N6 methyltransferase CcrM / Razvan Florin Albu." Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2013. http://d-nb.info/1035267519/34.

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9

Zhou, Binbin. "Identification and characterization of target genes of RRS1-R, a protein conferring resistance in Arabidopsis thaliana to the pathogenic bacterium Ralstonia solanacearum." Toulouse 3, 2014. http://thesesups.ups-tlse.fr/2604/.

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Ralstonia solanacearum, agent du flétrissement bactérien, affecte près de 200 espèces végétales. Les gènes RRS1-R confèrent à l'écotype d'A. Thaliana Nd-1 une résistance à différentes souches de R. Solanacearum. RRS1-R code une protéine de structure modulaire associant les domaines typiques de nombreuses protéines de résistance TIR-NBS-LRR et un domaine signature de facteurs de transcription WRKY. Dans l'écotype sensible Col-0, le gène RRS1-S code pour une protéine qui présente une structure très semblable. Au cours de ce travail, nous avons montré que les gènes RRS1-R et RRS1-S s'expriment es

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10

Willcock, Damion F. "A mutational analysis of motifs in EcoKI common to adenine methyltransferases." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/11580.

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Type 1 restriction/modification systems are complex multifunctional enzymes comprising three polypeptides, Hsd R, M and S. All three polypeptides are required to form a restriction enzyme but M and S alone are sufficient to form an N6 adenine methyltransferase. The Hsd M polypeptide of the type I system <I>Eco </I>K contains motifs characteristic of N6 adenine methyltransferases (Asn/Asp Pro Pro Phe/Tyr) and of methyltransferases in general (Phe X Gly X Gly). These motifs may identify amino acid sequences critical to methyltransferase function. This work describes an in vivo and in vitro analy

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11

Zheng, Sushuang. "Structure-function analyses of Encephalitozoon cuniculi : and vaccinia virus mRNA cap (guanine N-7) methyltransferases and sinefungin resistance of Saccharomyces cerevisiae /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1528353811&sid=5&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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12

Baker, Matthew. "Synthesis, Screening and Cocrystallization of Adenosine Based Inhibitors with Methyltransferases, ErmC' and KsgA." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/277.

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Antibiotic resistance threatens to throw mankind back into an era when infectious disease was the predominant cause of death. In an effort to mitigate this danger, we targeted ErmC’ and KsgA. Both methylate N6-adenosine of ribosomal RNA, though each serve different roles in their bacterial host. ErmC’ dimethylates A2058 on 23S rRNA, conferring resistance to MLSB antibiotics (macrolides, lincosamides, streptogramin B). KsgA aids in ribosome assembly, binding inactive 30S until dimethylating A1518/A1519 of 16S rRNA. Like most methyltransferases, ErmC’ and KsgA use cofactor S-adenosylmethionine (

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13

Desai, Pooja. "ADENOSINE DIMETHYLTRANSFERASE KsgA: BIOCHEMICAL CHARACTERIZATION OF THE PROTEIN AND ITS INTERACTION WITH THE 30S SUBUNIT." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1915.

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Ribosomes form the core of the protein biosynthesis machinery and are essential to life. Ribosome biogenesis is a complex cellular process involving transcription of rRNA, pre-rRNA processing, rRNA modification and simultaneous assembly of ribosomal proteins. RNA nucleotide modification is observed in all domains of life. While there is enormous conservation of ribosome structure, very few post-transcriptional rRNA modifications have been conserved throughout evolution. A notable example of such rare conservation is the dimethylation of two adjacent adenosines in the 3’-terminal helix, a highl

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14

Katti, Christiana. "Characterization of the S-adenosyl-L-methionine binding subunit of the mRNA (N⁶-adenosine) methyltransferase /." View abstract, 2005. http://wwwlib.umi.com/dissertations/fullcit/3205449.

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15

Bouvet, Mickaël. "Etude d'enzymes de modification d'ARN impliquées dans la réplication des flavivirus et des coronavirus." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20714.

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Ce travail de thèse a porté sur l’étude d’activités enzymatiques virales impliquées dans la réplication de deux genres viraux : les Flavivirus et les Coronavirus. Dans un premier temps, nous avons étudié des activités enzymatiques impliquées dans la formation de la structure coiffe des ARNm viraux. En effet, du fait de leur cycle réplicatif cytoplasmique, ces virus n’ont pas accès à la machinerie de formation de la coiffe cellulaire et expriment donc une machinerie dédiée. Le processus canonique de formation de la coiffe fait appel à quatre activités enzymatiques, une ARN 5’-triphosphatase, un

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16

Banerjee, Arun. "Biochemical Characterization Of An Acid-Adaptive Type III DNA Methyltransferase From Helicobacter Pylori 26695 And Its Biological Significance." Thesis, 2011. https://etd.iisc.ac.in/handle/2005/2420.

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Enzyme DNA methylation is an important biochemical process that imprints DNA with additional information. DNA methylation is catalyzed by S-adenosyl-L-methionine (AdoMet)-dependent methyltraferases (MTases). Prokaryotic DNA MTases are usually components of restriction-modification(R-M) systems that enable cells to resist propagation of foreign genomes that would otherwise kill them. Based on the position methyl group transfer on the bases in DNA, MTases are classified into two groups-exocyclic or amino MTases and endocyclic or ring MTases. The amino MTases methylate exocyclic amino nitrogen to

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17

Banerjee, Arun. "Biochemical Characterization Of An Acid-Adaptive Type III DNA Methyltransferase From Helicobacter Pylori 26695 And Its Biological Significance." Thesis, 2011. http://etd.iisc.ernet.in/handle/2005/2420.

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Enzyme DNA methylation is an important biochemical process that imprints DNA with additional information. DNA methylation is catalyzed by S-adenosyl-L-methionine (AdoMet)-dependent methyltraferases (MTases). Prokaryotic DNA MTases are usually components of restriction-modification(R-M) systems that enable cells to resist propagation of foreign genomes that would otherwise kill them. Based on the position methyl group transfer on the bases in DNA, MTases are classified into two groups-exocyclic or amino MTases and endocyclic or ring MTases. The amino MTases methylate exocyclic amino nitrogen to

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18

Chaudhary, Awanish Kumar. "Characterization Of HP1369-HP1370 From Helicobacter Pylori : A Novel ε Type N6 –Adenine Methyltransferase". Thesis, 2011. https://etd.iisc.ac.in/handle/2005/2125.

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Helicobacter pylori is one of the most genetically diverse bacterial species that successfully colonizes at least 50% of the world population. It has been associated with humans for thousands of years and most probably evolved from ancestral gastric Helicobacter species in early mammals. One of the important characteristics of this pathogen is the degree of allelic diversity and genetic variability which helps it to adapt and colonize. Phase variation is one of the mechanisms used by H. pylori to generate variation. The presence of homopolymeric nucleotide or dinucleotide repeats in an ORF mak

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19

Chaudhary, Awanish Kumar. "Characterization Of HP1369-HP1370 From Helicobacter Pylori : A Novel ε Type N6 –Adenine Methyltransferase". Thesis, 2011. http://etd.iisc.ernet.in/handle/2005/2125.

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Helicobacter pylori is one of the most genetically diverse bacterial species that successfully colonizes at least 50% of the world population. It has been associated with humans for thousands of years and most probably evolved from ancestral gastric Helicobacter species in early mammals. One of the important characteristics of this pathogen is the degree of allelic diversity and genetic variability which helps it to adapt and colonize. Phase variation is one of the mechanisms used by H. pylori to generate variation. The presence of homopolymeric nucleotide or dinucleotide repeats in an ORF mak

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20

Kumar, Ritesh. "Helicobacter Pylori Restriction-Modification Systems : Possible Roles Beyond Genome Protection." Thesis, 2010. https://etd.iisc.ac.in/handle/2005/2029.

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Helicobacter pylori is one of the most potential and successful human pathogen which colonizes atleast 50% of world population. One of the important characteristics of this pathogen is the degree of allelic diversity and genetic variability which helps it to adapt and colonize. Phase variation is one of the mechanisms used by Helicobacter pylori to generate variation, where presence of homopolymeric nucleotide or dinucleotide repeats in an ORF make it prone to frequent length changes as a consequence of slipped strand mispairing mediated mutagenesis. An important feature of H. pylori biology

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21

Kumar, Ritesh. "Helicobacter Pylori Restriction-Modification Systems : Possible Roles Beyond Genome Protection." Thesis, 2010. http://etd.iisc.ernet.in/handle/2005/2029.

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Helicobacter pylori is one of the most potential and successful human pathogen which colonizes atleast 50% of world population. One of the important characteristics of this pathogen is the degree of allelic diversity and genetic variability which helps it to adapt and colonize. Phase variation is one of the mechanisms used by Helicobacter pylori to generate variation, where presence of homopolymeric nucleotide or dinucleotide repeats in an ORF make it prone to frequent length changes as a consequence of slipped strand mispairing mediated mutagenesis. An important feature of H. pylori biology i

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22

Reddy, Yeturu Venkatarami. "Role Of Cysteine Residues And Target Base Eversion In M.EcoP151 Mediated Methyl Transfer Reaction." Thesis, 1999. https://etd.iisc.ac.in/handle/2005/1611.

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23

Reddy, Yeturu Venkatarami. "Role Of Cysteine Residues And Target Base Eversion In M.EcoP151 Mediated Methyl Transfer Reaction." Thesis, 1999. http://etd.iisc.ernet.in/handle/2005/1611.

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24

Nogueira, Vanda Cristina Simões. "Role of adenosine on the resistance to temozolomide anti-tumor agent in glioblastoma." Master's thesis, 2020. http://hdl.handle.net/10400.6/10537.

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Glioblastoma is a primary brain tumor of glial cells with a high incidence in adults and is one of the most abundant brain cancer pathologies. This type of tumor is associated with high genomic instability caused by global hypomethylation of the DNA, that induces activation of oncogenes, loss of imprinting and increased genomic instability. Adenosine is a purine nucleoside important to neuroprotection, neuromodulation, synaptic plasticity and immunomodulation. In hypoxic and stress regions in the brain tumors, commonly found in glioblastoma, factors induced by hypoxia (HIF) are activated. Thes

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25

Goedecke, Karsten [Verfasser]. "Kristallstruktur der N6-Adenin-DNA-Methyltransferase aus Thermus aquaticus im Komplex mit DNA und einem Cofaktoranalogon : der katalytische Mechanismus und der durch DNA-Kompression induzierte Nukleotidausklappmechanismus / vorgelegt von Karsten Goedecke." 2000. http://d-nb.info/960519351/34.

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