Relevant bibliographies by topics / Adenine/pharmacology

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters

Academic literature on the topic 'Adenine/pharmacology'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Adenine/pharmacology"

1

She, Jing, Rui Sheng, and Zheng-Hong Qin. "Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors." Aging and disease 12, no. 8 (2021): 1879. http://dx.doi.org/10.14336/ad.2021.0523.

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Popova, Olga, Daria Bylinskaya, Anastasia Nikitina та Olga Ukrainskaya. "The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase". BIO Web of Conferences 181 (2025): 01026. https://doi.org/10.1051/bioconf/202518101026.

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The paper presents a theoretical study of the molecular mechanism of activation of the cytochrome P450 system by the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase in the catalytic cycle. The relevance of studying cytochrome P450 enzymes and their activator is determined by the development of methods for effective diagnostics of hepatobiliary pathologies. It was found that the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase functions as a redox “partner” for cytochromes P450. An electrochemical method used to study
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Zeng, Yijia, Tingna Li, Xiaorui Zhang, et al. "Effects of Haima Duobian Pill in a Rat Model of Kidney Yang Deficiency Syndrome." Evidence-Based Complementary and Alternative Medicine 2021 (January 5, 2021): 1–13. http://dx.doi.org/10.1155/2021/6696234.

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Objective. Modern research shows that Haima Duobian pill (HDP) can relieve the kidney yang deficiency syndrome (KYDS), but the mechanism is still unclear. The aim of this work was to study the effects of HDP in a rat model of KYDS. Materials and Methods. The network pharmacology methods were used to predict the therapeutic effects of Haima Duobian pill. Adenine was used to establish the rat model of kidney yang deficiency syndrome. The general physical signs of rats were observed after different doses of Haima Duobian pill (HDP) were given. Serum cyclic adenosine monophosphate (cAMP), cyclic g
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Gromova, O. A., and I. Yu Torshin. "Systematic analysis of the experimental and clinical pharmacology of nicotinamide and prospects for the treatment of atherosclerosis." Experimental and Clinical Gastroenterology, no. 10 (January 18, 2023): 111–25. http://dx.doi.org/10.31146/1682-8658-ecg-206-10-111-125.

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Nicotinamide (niacin) is a PP (Pellagra-Preventive) vitamer necessary for the synthesis of nicotinamide adenine dinucleotide (NAD). The NAD molecule is a coenzyme of proteins involved in the synthesis of ATP from fats and carbohydrates. For more than 50 years, nicotinamide has been used as an antihyperlipidemic agent and to improve blood microcirculation. The results of a systematic analysis of 70417 publications on the pharmacology of nicotinamide made it possible to clarify the molecular mechanisms of the vasoprotective action of nicotinamide (including anti-inflammatory action), to summariz
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Al-Salabi, Mohammed I., and Harry P. de Koning. "Purine Nucleobase Transport in Amastigotes of Leishmania mexicana: Involvement in Allopurinol Uptake." Antimicrobial Agents and Chemotherapy 49, no. 9 (2005): 3682–89. http://dx.doi.org/10.1128/aac.49.9.3682-3689.2005.

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ABSTRACT Nucleobase and nucleoside transporters play central roles in the biochemistry of parasitic protozoa, as they lack the ability to synthesize purines de novo and are absolutely reliant upon purine salvage from their hosts. Furthermore, such transporters are potentially critical to the pharmacology of these important human pathogens, because they mediate the uptake of purine analogues, as well as some nonpurine drugs, that can be selectively cytotoxic to the parasites. We here report the first identification and characterization of a purine nucleobase transporter in Leishmania amastigote
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Ray, Adrian S., Jennifer E. Vela, Constantine G. Boojamra, et al. "Intracellular Metabolism of the Nucleotide Prodrug GS-9131, a Potent Anti-Human Immunodeficiency Virus Agent." Antimicrobial Agents and Chemotherapy 52, no. 2 (2007): 648–54. http://dx.doi.org/10.1128/aac.01209-07.

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ABSTRACT GS-9131 is a phosphonoamidate prodrug of the novel ribose-modified phosphonate nucleotide analog GS-9148 that demonstrates potent anti-human immunodeficiency virus type 1 (HIV-1) activity and an excellent resistance profile in vitro. Prodrug moieties were optimized for the efficient delivery of GS-9148 and its active diphosphate (DP) metabolite to lymphoid cells following oral administration. To understand the intracellular pharmacology of GS-9131, incubations were performed with various types of lymphoid cells in vitro. The intracellular accumulation and antiviral activity levels of
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Fu, Yu, Xinya Zhang, Zhenguang Song, Lili Wang, Peng Zhao, and Suiqing Chen. "Exploring the Active Constitutions of Peach Blossom for Amelioration of Loperamide-Induced Mice Constipation by Ultra-Performance Liquid Chromatography-Mass Spectrometry Combined with Network Pharmacology." Natural Product Communications 18, no. 3 (2023): 1934578X2311611. http://dx.doi.org/10.1177/1934578x231161184.

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Constipation is a multifactorial health problem resulting from systemic or neurologic disorders including medication. Peach blossom, an edible flower, could promote defecation, urination, and improve abdominal pain. However, the active components and mechanisms of action remain unclear. In the present study, we established a loperamide-induced mice constipation model to validate the anti-constipation activity of peach blossom. Some classical biomarkers for constipation, including fecal water content, gastrointestinal transit ratio, and fecal pellet weight were used to evaluate the efficacy of
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8

Grim, Shellee A., and Frank Romanelli. "Tenofovir Disoproxil Fumarate." Annals of Pharmacotherapy 37, no. 6 (2003): 849–59. http://dx.doi.org/10.1345/aph.1c388.

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OBJECTIVE: To review the pharmacology, virology, pharmacokinetics, efficacy, safety, resistance profile, and clinical use of tenofovir disoproxil fumarate. DATA SOURCES: A MEDLINE search was performed (1966–August 2002) using the following terms: tenofovir, tenofovir disoproxil fumarate, PMPA (9-( R)-[2-(phosphonomethoxy)propyl]adenine), and Viread. Abstracts from HIV-related meetings were reviewed. DATA EXTRACTION AND STUDY SELECTION: Publications and meeting abstracts regarding tenofovir were reviewed. The most recent and pertinent items were included. DATA SYNTHESIS: Tenofovir disoproxil fu
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Gaffer, Hatem, Mounir Salem, and Magda Marzouk. "Synthesis of 4-hydroxy coumarin dyes and their applications." Pigment & Resin Technology 45, no. 5 (2016): 320–29. http://dx.doi.org/10.1108/prt-09-2014-0071.

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Purpose The present study aims to focus on the possibility of developing new eco-friendly azo dyes with good colouristic application properties, exhibiting biological and pharmacological activities. Design/methodology/approach Coupling of 4-hydroxycoumarin with a variety of aromatic diazonium salts of 2-aminothiazole, 2-aminobenzothiazole, 4-aminoantipyrine, 4-aminoacetophenone, adenine sulphate, a-naphthylamine and sulphadimidine to produce novel azo dyes. The compounds were fully characterised using spectroscopic and analytical methods. All of the compounds were tested for their antimicrobia
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Chu, Jiaxin, Jianqiang Song, Zhuolin Fan, et al. "Investigating the Effect and Mechanism of 3-Methyladenine Against Diabetic Encephalopathy by Network Pharmacology, Molecular Docking, and Experimental Validation." Pharmaceuticals 18, no. 5 (2025): 605. https://doi.org/10.3390/ph18050605.

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Background/Objectives: Diabetic encephalopathy (DE), a severe neurological complication of diabetes mellitus (DM), is characterized by cognitive dysfunction. 3-Methyladenine (3-MA), a methylated adenine derivative, acts as a biomarker for DNA methylation and exhibits hypoglycemic and neuroprotective properties. However, the pharmacological mechanisms underlying 3-MA’s therapeutic effects on diabetic microvascular complications remain incompletely understood, owing to the intricate and multifactorial pathogenesis of DE. Methods: This study employed network pharmacology and molecular docking tec
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Dissertations / Theses on the topic "Adenine/pharmacology"

1

Lim, Chloe Siew Suan. "Novel Ca2+ signalling pathways in vascular smooth muscle and endothelial cells." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:180b9f3d-449d-497f-b703-0e7bb2114183.

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Novel Ca<sup>2+</sup> signalling pathways in both endothelial cells and smooth muscle cells of rat small resistance arteries were investigated using a combination of confocal imaging, isometric tension recordings, and electrophysiology to study freshly isolated arteries and cells. We first examined the hypothesis that hyperpolarization could alter endothelial cell Ca<sup>2+</sup> events. Hyperpolarization evoked by direct opening of K<sub>ATP</sub> channels in the smooth muscle with levcromakalim triggered an increase in the frequency of Ca<sup>2+</sup> events in the endothelium of rat cremast
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McKelvie, Jennifer C. "Novel antibiotics from DNA adenine methyltransferase inhibitors." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/341769/.

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The re-emergence of plague as a world-wide health concern and the potential risk posed by bioterrorism has led to an increased interest in available treatments for the disease. The bacterial DNA adenine-N6 methyltransferase, Dam, is involved in the regulation of a range of pathogenic bacteria and has been validated as a target for the development of antimicrobial agents with activity against Yersinia pestis, the causative agent of plague. The lack of a functionally similar enzyme in mammals suggests that highly selective Dam inhibitors could be developed. A coupled, real-time break light Dam a
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Books on the topic "Adenine/pharmacology"

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1938-, Paton David M., Satellite Symposium on the "Physiology and Pharmacology of Adenosine and Adenine Nucleotides" (1987 : School of Medicine, University of Auckland), and International Congress of Pharmacology (10th : 1987 : Sydney, N.S.W.), eds. Adenosine and adenine nucleotides: Physiology and pharmacology. Taylor & Francis, 1988.

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Paton, David M. Adenosine and Adenine Nucleotides: Physiology and Pharmacology. Taylor & Francis Group, 1988.

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Book chapters on the topic "Adenine/pharmacology"

1

Enna, S. J., and David B. Bylund. "9-(Cyclopentenyl)-Adenine." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.63629-3.

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Enna, S. J., and David B. Bylund. "9-(Tetrahydrofuryl)-Adenine." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.63630-x.

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Enna, S. J., and David B. Bylund. "Reduced Nicotinamide Adenine Dinucleotide." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.63170-8.

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Enna, S. J., and David B. Bylund. "Reduced Nicotinamide Adenine Dinucleotide Phosphate." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.63169-1.

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Williams, Michael. "Erythro-9-(2 Hydroxy 3-Nonyl)Adenine." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.61136-5.

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You might also be interested in the extended bibliographies on the topic 'Adenine/pharmacology' for particular source types:
Journal articles
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