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Dissertations / Theses on the topic 'Adenoid Basal Cell Carcinoma'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Pirzado, Muhammad Suleman. "Investigating cell senescence in basal cell carcinoma." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8633.

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The Aim of the project was to investigate cell senescence in basal cell carcinoma (BCC). Although the concept of oncogene-induced senescence (OIS) was originally confined to cultured cells, it is now well established that this mechanism has an important role in tumour biology. OIS represents a physiological response that restricts the progression of benign tumours into their malignant counterparts e.g. nevi to melanoma or adenoma to adenocarcinoma. Full malignancy is associated with the loss of important tumour suppressor genes including RETINOBLASTOMA and/or TP53. BCC of the skin is the most

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2

Verhaegh, Marcus Emile Johannes Maria. "Growth characteristics of basal cell carcinoma." Maastricht : Maastricht : UPM, Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8543.

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3

Richmond-Sinclair, Naomi Monique. "The epidemiology of basal cell carcinoma." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/68152/1/Naomi_Richmond-Sinclair_Thesis.pdf.

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Basal cell carcinoma (BCC) is a skin cancer of particular importance to the Australian community. Its rate of occurrence is highest in Queensland, where 1% to 2% of people are newly affected annually. This is an order of magnitude higher than corresponding incidence estimates in European and North American populations. Individuals with a sun-sensitive complexion are particularly susceptible because sun exposure is the single most important causative agent, as shown by the anatomic distribution of BCC which is in general consistent with the levels of sun exposure across body sites. A distinguis

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4

Gore, S. "Neuronal differentiation markers in basal cell carcinoma." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445574/.

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Basal cell carcinoma (BCC) is the most common skin cancer in humans. The demonstration of genetic and protein alterations has, so far, had limited correlation with either biological behaviour or histological classification of these tumours. It was observed that Glil-overexpressing keratinocytes express elevated levels of genes known to be associated with neuronal development, including p-tubulin III, GAP-43, Arc and neurofilament. It was proposed that these genes may similarly be overexpressed in BCCs and that different levels of expression may be present in different BCC subtypes Immunohistoc

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5

Gao, Wendi. "Investigation of immune privilege in basal cell carcinoma." University of British Columbia, 2017. http://hdl.handle.net/2429/63553.

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Basal cell carcinoma (BCC) is the most common type of skin cancer which arises in the skin’s basal cells that line the deepest layer of the epidermis. Previous studies have identified some immune privilege (IP) related genes and products expressed in some malignancies. IP is also believed to exist in BCC tumors during BCC development. However, quantitative analyses and functional studies to clearly demonstrate IP in BCC tumors are required. My goal was to examine BCC tumor cells to identify novel functional mechanisms of IP. My hypothesis was that BCC tumors have functional IP capabilities. Wi

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6

de, Zwaan Sally Elizabeth. "The Genetics of Basal Cell Carcinoma of the Skin." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3878.

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BCC is the commonest cancer in European-derived populations and Australia has the highest recorded incidence in the world, creating enormous individual and societal cost in management of this disease. The incidence of this cancer has been increasing internationally, with evidence of a 1 to 2% rise in incidence in Australia per year over the last two decades. The main four epidemiological risk factors for the development of BCC are ultraviolet radiation (UVR) exposure, increasing age, male sex, and inability to tan. The pattern and timing of UVR exposure is important to BCC risk, with childhood

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7

de, Zwaan Sally Elizabeth. "The Genetics of Basal Cell Carcinoma of the Skin." University of Sydney, 2008. http://hdl.handle.net/2123/3878.

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Doctor of Philosophy(PhD)<br>BCC is the commonest cancer in European-derived populations and Australia has the highest recorded incidence in the world, creating enormous individual and societal cost in management of this disease. The incidence of this cancer has been increasing internationally, with evidence of a 1 to 2% rise in incidence in Australia per year over the last two decades. The main four epidemiological risk factors for the development of BCC are ultraviolet radiation (UVR) exposure, increasing age, male sex, and inability to tan. The pattern and timing of UVR exposure is importan

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8

Pantazi, Eleni. "The role of GLI2 in human basal cell carcinoma tumourigenesis." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/508.

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Abnormal Sonic Hedgehog (SHH) signalling leads to increased transcriptional activation of its downstream effector, GLI2, which is implicated in the pathogenesis of a variety of human tumours, including human basal cell carcinoma (BCC). However, little is known about the molecular mechanisms underlying the tumourigenic role of GLI2 in human skin keratinocytes. This study examines the effects of inducible and stable expression of constitutively active GLI2 (GLI2:N) oncogenic transcription factor, on immortalised human epidermal keratinocytes. It is shown here that GLI2:N overexpressing N/TERT ke

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9

Horlock, Nigel. "The cell biology of basal cell carcinoma : relationship to histology and clinical outcome." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391606.

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10

Wallberg, Peter. "A clinical and experimental study of basal cell carcinoma : aspects on epidemiology, genetics and microphysiology /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3993-4/.

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11

Wong, Deanna A. "Cytokine profiles in regressing and non-regressing basal cell carcinomas." Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27687.

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12

Thissen, Monique Rosalie Thérèse Mathieu. "Treatment of basal cell carcinoma in the light of photodynamic therapy." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2000. http://arno.unimaas.nl/show.cgi?fid=5962.

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13

Cheng, Hui Mei. "Diagnostic accuracy of optical coherence tomography in superficial basal cell carcinoma." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14183.

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Background: Superficial basal cell carcinoma (sBCC) can be safely treated topically. Potentially, non-invasive imaging techniques, such as optical coherence tomography (OCT), may be useful to diagnose sBCC without biopsy. Objective: To evaluate OCT’s 1) sensitivity and specificity for sBCC diagnosis 2) accuracy in determining BCC depth Methods: A prospective, consecutive cohort of lesions for which sBCC was considered in the differential diagnosis underwent clinical, dermoscopic and OCT assessment. Diagnosis and its confidence were recorded for each modality and correlated with the histop

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14

Calderón, Gómez Tomás Alberto. "Detecting basal cell carcinoma in skin histopathological images using deep learning." Thesis, Massachusetts Institute of Technology, 2018. https://hdl.handle.net/1721.1/121624.

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This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (page 51).<br>In this thesis we explore different machine learning techniques that are common in image classification to detect the presence of Basal Cell Carcinoma (BCC) in digital skin histological images. Since digital histology i

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15

Undén, Anne Birgitte. "Studies on basal cell carcinoma with emphasis on the role of the human homologue of the drosophila patched gene /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2788-X.

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16

Searby, Caroline. "Development of a topical formulation for the treatment of basal cell carcinoma." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/55529/.

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Despite the ability to modulate SHH signalling, EGF pathway inhibitors targeting pAKT and pERK may not be useful for treating basal cell carcinoma. Alternative SHH signalling inhibitors such as those that target the formation of the primary cilium may be highly effective.

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17

El-Genidy, Noha A. F. "Association of PTCH polymorphism with clinical phenotype in basal cell carcinoma patients." Thesis, Keele University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436141.

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18

Farndon, Peter Anthony. "The gorlin (naevoid basal cell carcinoma) syndrome : a clinical and genetic study." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307577.

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19

Kaur, Ravneet. "THRESHOLDING METHODS FOR LESION SEGMENTATION OF BASAL CELL CARCINOMA IN DERMOSCOPY IMAGES." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1367.

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Purpose: Automatic border detection is the first and most crucial step for lesion segmentation and can be very challenging, due to several lesion characteristics. There are many melanoma border-detecting algorithms that perform poorly on dermoscopy images of basal cell carcinoma (BCC), which is the most common skin cancer. One of the reasons for poor lesion detection performance is that there are very few algorithms that detect BCC borders, because they are difficult to segment, even for dermatologists. This difficulty is due to low contrast, variation in lesion color and artifacts inside/outs

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20

Krekels, Gertruud Anna Maria. "Basal cell carcinoma, a disease on the increase implications for treatment and prevention /." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8428.

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21

Hauser, Jennifer E. M. S. "Genetic Epidemiology of Radiation Sensitivity and Basal Cell Carcinoma in Childhood Cancer Survivors." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447689192.

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22

Koreeda, Satoshi. "Basal cell carcinoma cells resemble follicular matrix cells rather than follicular bulge cells." Kyoto University, 2004. http://hdl.handle.net/2433/147556.

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23

Evangelou, Dr Georgios. "Molecular effects of topical photodynamic therapy in healthy human skin and basal cell carcinoma." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493421.

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Topical photodynamic therapy (PDT) elicits a therapeutic response in both non melanoma skin cancer and immune-mediated skin disorders. Production of reactive oxygen species may result in direct cell death; however PDT-induced inflammatory and immune responses may also contribute to the therapeutic effects. The aims of my thesis were to examine for evidence of topical PDT-induced apoptosis and leucocyte trafficking, and the mechanisms underlying their mediation, in human skin.

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24

Asplund, Anna. "Molecular Analysis of Normal Human Skin and Basal Cell Carcinoma Using Microdissection Based Methods." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5795.

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25

Elliott, Jane Alannah. "An in vitro study of the potential stromal role in basal cell carcinoma development." Thesis, Queen Mary, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.576917.

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Basal Cell Carcimona (BCC) is the most common form of skin cancer in the UK, occurring most frequently on sun exposed sites such as the head, neck and trunk and has been associated with mutations in genes expressed by keratinocytes. In particular, the mutation of the Patched receptor of the Hedgehog signalling pathway results in the up regulation of the target transcription factor GU 1. BCCs also have a complex stroma which consists of dermal fibroblasts. Dermal fibroblasts form a supportive structure through the production and release of collagens for extracellular matrices and the expression

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26

Rejas, Roberto Anaximandro Garcia. "Expressão das proteinas c-jun, junb, JNK e pc-jun no carcinoma adenóide cístico e carcinoma epidermóide da cavidade bucal." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-06032012-161940/.

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O carcinoma adenóide cístico e o carcinoma epidermóide são neoplasmas de origem epitelial que afetam a cavidade oral. O carcinoma adenóide cístico pode apresentar-se em glândulas salivares maiores e menores, possue alta propensão de invasão perineural e o padrão de infiltracão: sólido, tubular e cribriforme. O carcinoma epidermóide foi descrito como um processo multifatorial envolvendo agentes físicos, químicos e virais, capazes de afetar o metabolismo celular e induzir a proliferação neoplásica. As proteínas c-jun e junB são membros da familia JUN, capazes de homodimerizar ou heterodimerizar

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27

Brownlie, Laura. "Differential gene expression studies in non-melanoma skin cancer." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323449.

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28

Khalil, Tayma. "Basal-like breast cancers : characterization and therapeutic approaches." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112520.

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Background. Both basal-like subtype and BRCA1-related breast cancers tend to have a poor overall prognosis and lack of effective treatments. Given that the lung cancer drug gefitinib and the leukemia drug dasatinib inhibit proteins also belonging to the molecular signature of this subtype, we and others hypothesized that they might be useful therapies for those two breast cancer subgroups.<br>Methods. Eight breast cancer cell lines were characterized by immunohistochemistry and western blotting and were treated with both drugs. Response was measured by using the sulphorhodamine B (SRB) assay.<

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29

Bladen, John Christopher. "Identification of genetic factors involved in morphoeic basal cell and sebaceous gland carcinoma of human eyelid tumours with a view to identifying potential treatment targets." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25807.

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Periocular malignancy represents an increasing burden and currently requires disfiguring surgery in an attempt to cure patients. Basal cell carcinoma (BCC) is the commonest cancer worldwide and morphoeic BCC (mBCC) is an aggressive subtype. Sebaceous gland carcinoma (SGC) is a rare, but life-threatening condition that often requires blinding surgery to prevent mortality, especially in the pagetoid subtype. MBCC has a high risk of local recurrence compared to the more indolent nodular subtype reflected by a different set of driver genes including FLNB and HECTD4. Surrounding mBCC stroma is abno

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30

Essers, Brigitte Agnes Bernadette. "Surgical excision and Mohs Micrographic Surgery for basal cell carcinoma an evaluation from different perspectives /." Maastricht : Maastricht : [Maastricht University] ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=11247.

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31

Lo, Blanche Ka Ki. "CXCR3 signaling effects on the development and immunoregulation of basal cell carcinoma and related neoplasias." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/41381.

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Increasing evidence has revealed that the chemokines CXCL9, CXCL10, CXCL11, and their common receptor CXCR3, are associated with tumorigenesis. Basal cell carcinoma (BCC) is a type of non-melanoma skin cancer (NMSC) and is the most common malignancy encountered. In this thesis, I hypothesized that CXCR3 signaling provides a novel marker for the growth and putative immune privilege of BCC as well as for the development of other NMSCs, such as cutaneous squamous cell carcinoma (SCC). Increased expression of chemokines CXCL10, 11 and CXCR3 was detected in cytokeratin 17 (K17)⁺ BCC cells. CXCR3/CX

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Matas, Nadal Clara. "Carcinomes de queratinòcits: aspectes epidemiològics a Catalunya i caracterització proteica del seu fluid intersticial tumoral." Doctoral thesis, Universitat de Lleida, 2021. http://hdl.handle.net/10803/672236.

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Introducció: Els carcinomes de queratinòcits (CQ) són la neoplàsia maligna més freqüent a nivell mundial en poblacions caucàsiques. En conjunt, suposen un enorme problema de salut, tant en termes de morbiditat com de despesa sanitària. En les darreres dècades, la seva incidència ha augmentat de manera significativa. A més a mes, pel que fa al carcinoma basocel·lular (CBC), han augmentat dramàticament els casos entre la gent jove, sobretot dones. Els CQ tenen, en general, un bon pronòstic. Malgrat això, el CBC pot créixer localment destruint els teixits circumdants i causant importants seqüeles

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33

Kass, Youssef Khalil. "Identification of cellular origin and molecular mechanism in basal and squamous cell carcinomas." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209771.

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Skin cancers are very common in humans. The two most frequent epithelial skin cancers are the basal cell carcinoma (BCC) and the squamous cell carcinoma (SCC). For the vast majority of cancers, the cell at the origin of tumour initiation is still unknown and assumptions concerning their origin rely mainly on morphological and immunohistochemical studies. Recently, adult stem cells (SCs) have been suggested to be at the origin of tumour initiation based on their long term self-renewing capacities. According to these, two important questions arise; do epithelial skin cancers arise from mutations

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34

Cheng, Beibei. "Automatic vessel and telangiectases analysis in dermoscopy skin lesion images." Diss., Rolla, Mo. : Missouri University of Science and Technology, 2009. http://scholarsmine.mst.edu/thesis/pdf/Cheng_09007dcc80636a0d.pdf.

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Thesis (M.S.)--Missouri University of Science and Technology, 2009.<br>Vita. The entire thesis text is included in file. Title from title screen of thesis/dissertation PDF file (viewed April 13, 2009) Includes bibliographical references (p. 46).

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35

Bianchi, Lucia. "Elucidating the expression pattern and role of the oncogenic GLI transcription factors in basal cell carcinoma." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/3165.

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Basal Cell Carcinoma (BCC) is the most common type of skin cancer; its development is associated with mutational inactivation of the PTCH1 tumour suppressor gene leading to deregulation of the Hedgehog pathway through increased expression of the downstream GLI (GLI1 and GLI2) transcription factors. The high expression of GLI1 and GLI2 has also been shown to be maintained through a positive feedback mechanism in human keratinocytes, but this has partly relied upon mRNA expression and has not been fully explored at the protein level. Moreover, expression analysis in human BCCs has largely relied

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36

Larsimont, Jean-Christophe. "Identification of the molecular mechanisms involved in the initiation, invasion and maintenance of basal cell carcinoma." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/271467.

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Le carcinome basocellulaire (CBC) est le cancer le plus fréquent chez l’homme et est à lui seulresponsable de plus de cas que l’incidence cumulée de tous les autres cancers réunis. Des travauxrécents qui se sont intéressés aux étapes précoces de la tumorigenèse ont fourni un supportprécieux pour l’analyse du développement tumoral précoce. Ils ont mis en évidence le rôlecentral de gènes impliqués dans les progéniteurs embryonnaires des cellules souches du folliculepileux. Dans ce travail, nous avons étudié le rôle du facteur de transcription Sox9, un gène connupour être crucial dans la spécific

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37

Edlund, Karolina. "Microdissection of well defined cell populations for RNA isolation in the analysis of normal human skin and basal cell carcinoma." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6148.

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<p>The human skin provides us with an excellent protective barrier and possesses a remarkable ability of constant renewal. Basal cell carcinoma is the most common type of skin cancer. The aim of this project was to verify results from an earlier study investigating the molecular differences between basal cell carcinoma (BCC) and basal cells of normal human epidermis. In that study microdissection of cell populations from BCC and basal cells of normal epidermis respectively was performed in five cases of confirmed BCC. Following RNA extraction and amplification, a gene expression analysis was p

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38

Iannacone, Michelle R. "Case-Control Study of Sunlight Exposure and Cutaneous Human Papillomavirus Seroreactivity in Basal Cell and Squamous Cell Carcinomas of the Skin." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3164.

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Non-melanoma skin cancer (NMSC), comprised of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is the most common cancer in Caucasians. Ultraviolet radiation (UVR) exposure is the most important environmental risk factor for both BCC and SCC development. However, the precise relationship between UVR and the risk of NMSC is complex, and the relationship may differ by skin cancer type. It has been hypothesized that intermittent patterns and childhood sunlight exposure are important for BCC while continuous (chronic) and lifelong (i.e. childhood and adulthood) sunlight exposure is

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39

Ramachandran, Sudarshan. "Identification of genetic and host factors associated with clinical phenotypes in patients with cutaneous basal cell carcinoma." Thesis, Keele University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402689.

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40

Ikram, Mohammed S. "Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems." Thesis, Queen Mary, University of London, 2007. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1527.

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Embryonic development is regulated by a number of signalling pathways, which are critical for normal growth. Many of these genes then continue to play an important role in the regulation of cell growth and differentiation in adult. One such pathway is the sonic hedgehog (SHH) pathway; SHH protein is secreted which binds to its receptor patched (PTCH), leading to the activation and repression of target genes via zinc-finger GLI family transcription factors. Deregulation of this pathway, leads to a number of human birth defects and diseases such as Basal Cell Carcinoma (BCC) of the skin. In tran

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41

D’Uva, Gabriele Matteo <1980&gt. "Stem cell pathways in the basal-like breast carcinoma: the role of beta-catenin and HIF-1alpha." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3429/1/DUva_Gabriele_Matteo_tesi.pdf.

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Basal-like tumor is an aggressive breast carcinoma subtype that displays an expression signature similar to that of the basal/myoepithelial cells of the breast tissue. Basal-like carcinoma are characterized by over-expression of the Epidermal Growth Factor receptor (EGFR), high frequency of p53 mutations, cytoplasmic/nuclear localization of beta-catenin, overexpression of the Hypoxia inducible factor (HIF)-1alpha target Carbonic Anhydrase isoenzime 9 (CA9) and a gene expression pattern similar to that of normal and cancer stem cells, including the over-expression of the mammary stem cell marke

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42

D’Uva, Gabriele Matteo <1980&gt. "Stem cell pathways in the basal-like breast carcinoma: the role of beta-catenin and HIF-1alpha." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3429/.

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Basal-like tumor is an aggressive breast carcinoma subtype that displays an expression signature similar to that of the basal/myoepithelial cells of the breast tissue. Basal-like carcinoma are characterized by over-expression of the Epidermal Growth Factor receptor (EGFR), high frequency of p53 mutations, cytoplasmic/nuclear localization of beta-catenin, overexpression of the Hypoxia inducible factor (HIF)-1alpha target Carbonic Anhydrase isoenzime 9 (CA9) and a gene expression pattern similar to that of normal and cancer stem cells, including the over-expression of the mammary stem cell marke

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43

Lima, Jacqueline Silva Brito [UNESP]. "Expressão de fatores de proliferação e antiapoptóticos em carcinomas basocelulares." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/148646.

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Carless, Melanie, and n/a. "Molecular Analysis of Non-Melanoma Skin Cancer." Griffith University. School of Health Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20041101.123114.

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Non-melanoma skin cancer (NMSC) is the most common cancer in the world with a lifetime risk for development as high as 2 in 3 in Queensland, Australia. Mortality is quite low, representing an approximate 360 deaths in Australia annually but cost of treatment is extremely high, estimated at $232 million each year. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the two most common forms of NMSC. Although BCC generally do not have the propensity to metastasise, they are highly invasive and can be locally destructive. SCC on the other hand is invasive and has metastatic potential

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45

Carless, Melanie. "Molecular Analysis of Non-Melanoma Skin Cancer." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/367527.

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Non-melanoma skin cancer (NMSC) is the most common cancer in the world with a lifetime risk for development as high as 2 in 3 in Queensland, Australia. Mortality is quite low, representing an approximate 360 deaths in Australia annually but cost of treatment is extremely high, estimated at $232 million each year. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the two most common forms of NMSC. Although BCC generally do not have the propensity to metastasise, they are highly invasive and can be locally destructive. SCC on the other hand is invasive and has metastatic potential

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46

Ruocco, Margherita <1981&gt. "Generation and characterization of mouse models of Small cell lung cancer and Basal cell carcinoma for the preclinical evaluation of new therapies." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5623/1/Ruocco_Margherita_TESI.pdf.

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Background. Human small cell lung cancer (SCLC) accounting for approximately 15-20% of all lung cancers, is an aggressive tumor with high propensity for early regional and distant metastases. Although the initial tumor rate response to chemotherapy is very high, SCLC relapses after approximately 4 months in ED and 12 months in LD. Basal cell carcinoma (BCC) is the most prevalent cancer in the western world, and its incidence is increasing worldwide. This type of cancer rarely metastasizes and the death rate is extraordinary low. Surgery is curative for most of the patients, but for those that

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47

Ruocco, Margherita <1981&gt. "Generation and characterization of mouse models of Small cell lung cancer and Basal cell carcinoma for the preclinical evaluation of new therapies." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5623/.

Full text

Abstract:

Background. Human small cell lung cancer (SCLC) accounting for approximately 15-20% of all lung cancers, is an aggressive tumor with high propensity for early regional and distant metastases. Although the initial tumor rate response to chemotherapy is very high, SCLC relapses after approximately 4 months in ED and 12 months in LD. Basal cell carcinoma (BCC) is the most prevalent cancer in the western world, and its incidence is increasing worldwide. This type of cancer rarely metastasizes and the death rate is extraordinary low. Surgery is curative for most of the patients, but for those that

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48

Schlittler, Fabian Lukas. "Staged surgical therapy of basal cell carcinoma of the head and neck region : an evaluation of 500 proceducers /." Bern, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000278322.

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49

Lear, John T. "Susceptibility to basal cell carcinoma (BCC) : the influence of individual characteristics and polymorphism in loci encoding detoxifying enzymes." Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/29550.

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BCC is the commonest malignancy in white people and presents a great burden to health care provision. The genetic factors and individual characteristics associated with susceptibility to this cancer are still largely unclear. Since ultraviolet radiation constitutes an oxidative stress to skin cells, the ability to deal with the products of oxidative stress-induced damage may be important in determining BCC risk. The influence of detoxifying enzyme gene polymorphisms (glutathione S-transferases (GST) GSTM1, GSTT1, GSTM3) and cytochrome P450's (CYP) CYP1A1 and CYP2D6 on susceptibility to BCC was

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50

Ichii-Jones, Fumiyo. "A study of genetic factors that determine clinical phenotype in skin cancer : basal cell carcinoma and malignant melanoma." Thesis, Keele University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368988.

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