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Journal articles on the topic 'Adenoma, Pleomorphic'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Nishimura, Toshiro, Mitsuru Furukawa, Ei Kawahara, and Atsuo Miwa. "Differential diagnosis of pleomorphic adenoma by immunohistochemical means." Journal of Laryngology & Otology 105, no. 12 (December 1991): 1057–60. http://dx.doi.org/10.1017/s0022215100118183.

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AbstractImmunohistochemical study of major salivary gland tumours was performed on 60 pleomorphic adenomas, five basal cell adenomas and 10 adenoid cystic carcinomas to determine the diagnostic value of each antigen. Immunoreactivity examined were intermediate filaments (keratin, vimentin, desmin and glial fibrillary acidic protein [GFAP]) and related substances (actin, S-100 protein and secretory component). In pleomorphic adenomas, there was positive immunoreactivity for GFAP which was not observed in normal tissue or other neoplastic tissues. Immunoreactivity of GFAP was closely related to myxomatous and early chondromatous differentiation in pleomorphic adenoma. It is considered that GFAP immunoreactivity should be assessed in the occasional differential diagnostic dilemma of pleomorphic adenoma versus adenoid cystic carcinoma and basal cell adenoma, because of its ability to show potential and definite myxochondromatous differentiation.

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2

Kumar, R., D. Nair, P. Pai, and P. Chaturvedi. "Laser Resection of Subglottic Pleomorphic Adenoma." International Journal of Head and Neck Surgery 1, no. 3 (2010): 175–77. http://dx.doi.org/10.5005/jp-journals-10001-1034.

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Abstract Tumors arising from the minor salivary glands in the larynx are rare. The most common tumors occurring here are adenoid cystic carcinomas.1 Among the benign tumors, pleomorphic adenoma is the most common.1 We present a case of subglottic pleomorphic adenoma which was managed by endolaryngeal endoscopic CO2 laser surgery. Laser as a primary treatment modality for the treatment of subglottic pleomorphic adenomas has not been well-described, as only one case has been reported in literature using this modality.

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3

Darling, Mark R., Nelly N. Hashem, Irene Zhang, Mohamed Mohamed, Kevin Fung, Keith Kwan, Tom W. Mara, Tom D. Daley, and Eleftherios P. Diamandis. "Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours." International Journal of Biological Markers 27, no. 4 (October 2012): 381–88. http://dx.doi.org/10.5301/jbm.2012.10373.

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Objectives Kallikrein-related peptidase 10 (KLK10) has been implicated in the development of several types of cancer. The purpose of this study was to analyze the expression of KLK10 in 3 types of salivary gland tumour and normal salivary glands. Materials and methods: A standard immunoperoxidase staining technique was used to assess the Immunoexpression profile of KLK10 in normal salivary glands and 3 types of salivary gland tumour: pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. Results Pleomorphic adenomas showed significantly lower KLK10 levels than control tissues. Neither of the malignant tumours (adenoid cystic carcinoma and mucoepidermoid carcinoma) showed a significant alteration in the immunoreactive scores of KLK10 in comparison with the normal salivary gland tissues. KLK10 immunoreactive scores were comparable in adenoid cystic carcinoma and mucoepidermoid carcinoma. Pleomorphic adenoma had significantly lower levels of KLK10 than mucoepidermoid carcinoma. Conclusions The finding of lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells. A kallikrein cascade may play a role in the development and/or outcome of some salivary gland tumours.

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4

Paudyal, P., K. Pande, A. Pradhan, R. Shah, P. Upadhyaya, and S. Thapa. "Pleomorphic adenoma of nasal septum: A case report." Journal of Pathology of Nepal 7, no. 1 (March 30, 2017): 1133–35. http://dx.doi.org/10.3126/jpn.v7i1.16947.

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Pleomorphic adenomas are the most common benign tumor of the major salivary glands. Other rare sites for the occurrence of pleomorphic adenoma have been described in the larynx, pharynx, nasal cavity, lacrimal glands and trachea. We report here a case of intranasal pleomorphic adenoma arising from the nasal septum causing nasal obstruction which was clinically diagnosed as papilloma. Histopathology confirmed the diagnosis of pleomorphic adenoma.

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5

Mouzali, Amina, Samia Lameche, Assia Slimani, and Omar Zemirli. "Pleomorphic Adenoma of the Ala Nasi: A Case Report." Clinical Medicine Insights: Ear, Nose and Throat 12 (January 2019): 117955061988656. http://dx.doi.org/10.1177/1179550619886561.

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Objectives: Pleomorphic adenomas are benign tumors that rarely involve nonsalivary glands. We report an uncommon case of ala nasi pleomorphic adenoma. We discuss the clinical and histopathologic characteristics, and review the literature on nasal pleomorphic adenoma. Method: A 20-year-old man presented with a painless slow growing lobulated mass located on the right ala nasi extending into the nasal vestibule. Results: Complete surgical excision was performed. Histologic examination found a mixed cellular component: epithelial and myoepithelial cells with chondromyxoid stroma. This was consistent with the diagnosis of a typical pleomorphic adenoma. There was no evidence of recurrence at 18 months after the surgery. Conclusions: Pleomorphic adenomas located in the external nose are extremely rare. In such case, pleomorphic adenoma could originate from ectopic minor salivary gland. Complete surgical excision with long-term follow-up is recommended due to the potential risk of recurrence and malignant transformation.

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6

Bhandari, Anuja, Shovana Karki, and Geeta Sayami. "Carcinoma ex pleomorphic adenoma of the parotid gland with cardiac metastasis." Journal of Pathology of Nepal 8, no. 2 (September 6, 2018): 1422–24. http://dx.doi.org/10.3126/jpn.v8i2.20899.

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Pleomorphic adenomas are the most common neoplasms of the major salivary glands. They are also known as benign mixed tumors because of the presence of both epithelial and mesenchymal elements. In parotid gland, approximately 65%-75% of tumors are pleomorphic adenomas. In parotid gland, usually it occur lateral to the plane of facial nerve. They present in middle aged patients as well defined, solitary, painless mass and are slow growing tumors. Few subset of tumors may undergo malignant transformation.Carcinoma ex pleomorphic adenoma is a rare and aggressive malignancy that arises from primary or recurrent pleomorphic adenoma. It occurs in 6% of all pleomorphic adenomas. Diagnosis of malignancy and treatment is largely based on pathologic and radiographic features. Distant metastases have been reported mainly in the lung. . We present an unusual case of 68 yrs female patient with carcinoma ex pleomorphic adenoma of the parotid gland with cardiac metastasis.

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7

Sim, David W., Arnold G. D. Maran, and Douglas Harris. "Metastatic salivary pleomorphic adenoma." Journal of Laryngology & Otology 104, no. 1 (January 1990): 45–47. http://dx.doi.org/10.1017/s0022215100111776.

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AbstractPleomorphic adenomas of the salivary gland are usually regarded as benign tumours. We report a case in which a solitary pulmonary metastasis arose from a pleomorphic adenoma of the right parotid gland. The mechanism of metastasis is discussed.

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8

Sroka, Paweł, and Sławomir Okła. "Giant pleomorphic adenoma of nasal cavities and paranasal sinuses." Polski Przegląd Otorynolaryngologiczny 7, no. 1 (June 27, 2018): 1–5. http://dx.doi.org/10.5604/01.3001.0012.1467.

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Pleomorphic adenoma is benign tumor of the salivary glands. It is the most common neoplazm both major and minor salivary glands. Only in 1% of cases pleomorphic adenoma occur in the sinonasal cavities. The histopalogical wiew of pleomorphic adenomas originating from small salivary glands is different in higher cellularity and lower stromal component than those from major salivary glands. It is a benign tumor but it should be treated as a clinically uncertain. Malignant transformation of pleomorphic adenoma can occur in 2-10% of cases, The aim of this study was to present he case of 37-year-old patient with giant pleomorphic adenoma of the sinonasal cavities causing extensive destruction of sinuses and orbits walls.

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9

Joshi, Sushant, HS Bhuie, and Navneet Mathur. "Pleomorphic Adenoma of Nasal Cavity: A Rare Case Report." An International Journal Clinical Rhinology 7, no. 2 (2014): 67–69. http://dx.doi.org/10.5005/jp-journals-10013-1198.

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ABSTRACT Pleomorphic adenomas are most common benign tumor of the major salivary gland, mainly found in parotid gland. Pleomorphic adenomas may also occur in the minor salivary glands of the hard and soft palate. Few cases are also diagnosed in various parts of pharynx and larynx. Intranasal pleomorphic adenomas can arise either from septum or lateral nasal wall. They are very rare entity and occasionally misdiagnosed due to their atypical histopathology. We present a rare case of pleomorphic adenoma diagnosed in middle-aged female originating from lateral wall of right nasal cavity. How to cite this article Joshi S, Bhuie HS, Mathur N, Verma H. Pleomorphic Adenoma of Nasal Cavity: A Rare Case Report. Clin Rhinol An Int J 2014;7(2):67-69.

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10

Tejendrasingh, Thakur Rahul, and Sonawale Sanjay Kumar Laxmanrao. "Pleomorphic Adenoma of the Nasal Septum." An International Journal of Otorhinolaryngology Clinics 5, no. 3 (2013): 151–53. http://dx.doi.org/10.5005/jp-journals-10003-1132.

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ABSTRACT Pleomorphic adenoma is a common, benign tumor arising from the major salivary glands, most commonly from the parotid gland. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual and may be misdiagnosed because they have greater myoepithelial cellularity and fewer myxoid stromata compared to those elsewhere. We report a case of pleomorphic adenoma of the nasal cavity arising from the nasal septum. How to cite this article Tejendrasingh TR, Laxmanrao SSK. Pleomorphic Adenoma of the Nasal Septum. Int J Otorhinolaryngol Clin 2013;5(3):151-153.

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11

MacIsaac, Zoe M., Sanjay Naran, and Joseph E. Losee. "Pleomorphic Adenoma." Journal of Craniofacial Surgery 24, no. 2 (March 2013): 669–71. http://dx.doi.org/10.1097/scs.0b013e3182802485.

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12

Buchman, Craig, Scott P. Stringer, William M. Mendenhall, James T. Parsons, James R. Jordan, and Nicholas J. Cassisi. "Pleomorphic Adenoma." Laryngoscope 104, no. 10 (October 1994): 1231???1234. http://dx.doi.org/10.1288/00005537-199410000-00008.

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13

Klijanienko, Jerzy, Vincent Servois, Patrice Jammet, Pierre Validire, Pierre Pouillart, Philippe Vielh, Adel K. El-Naggar, and Elisabeth Dulmet. "Pleomorphic Adenoma." American Journal of Surgical Pathology 22, no. 6 (June 1998): 772–73. http://dx.doi.org/10.1097/00000478-199806000-00017.

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14

Mitri, Stephanie, Joseph Yammine, and Khalil Diab. "Successful Resection of an Endobronchial Pleomorphic Adenoma Using Cryotherapy: A Case Report." International Journal of Clinical Research 2, no. 1 (May 23, 2021): 17–20. http://dx.doi.org/10.38179/ijcr.v2i1.58.

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Background: Pleomorphic adenomas are very rare benign bronchial tumors. They are typically either removed surgically, or if not amenable to surgery, via therapeutic bronchoscopy. We present the first case of an endobronchial pleomorphic adenoma removed by cryotherapy. Case Report: This is the case of a 54-year-old man with a right middle lobe pleomorphic adenoma that was detected incidentally during a bronchoscopy, which was performed due to acute respiratory failure and presence of ground glass opacities on imaging. The tumor led to a chronic cough and partial right middle lobe atelectasis. It was resected successfully using endobronchial cryotherapy without any noted complications. There has been no recurrence of disease one year after the intervention. Conclusion: This is the first report in the literature of a pleomorphic adenoma successfully removed via cryotherapy without recurrence. Endobronchial cryotherapy appears to be an effective and safe method of removing endobronchial pleomorphic adenomas.

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15

Carnate, Jose M., and Marvin C. Masalunga. "Intracapsular Carcinoma ex Pleomorphic Adenoma." Philippine Journal of Otolaryngology-Head and Neck Surgery 34, no. 1 (June 18, 2019): 68–69. http://dx.doi.org/10.32412/pjohns.v34i1.975.

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This is the case of a 37-year-old female patient presenting with a 10-year history of a gradually enlarging right infra-auricular mass. A parotidectomy was performed. The surgical pathology specimen consisted of an 18 cm diameter encapsulated nodular mass with a homogenous, cream-tan solid surface. Microscopic section showed an encapsulated neoplasm with abundant chondromyxoid stroma and tubular epithelial elements characteristic of a pleomorphic adenoma. (Figure 1) Randomly scattered within the tumor were foci of haphazard and complex glands. (Figure 2) These glands exhibited nuclear pleomorphism, luminal necrosis, and mitoses compatible with an adenocarcinomatous proliferation. (Figure 3) Based on these features, the case was signed out as an intracapsular carcinoma ex pleomorphic adenoma. Carcinoma ex pleomorphic adenoma is a carcinoma arising from a pre-existing pleomorphic adenoma. The antecedent benign tumor may either be a long-standing one, often with a history measured in decades, or characterized by a protracted history of excisions and multiple recurrences.1,2 The carcinoma on the other hand is either epithelial or myoepithelial in derivation. By morphologic sub-type, the most commonly reported carcinoma arising in a pleomorphic adenoma is a salivary duct carcinoma or an adenocarcinoma that is not otherwise specified (NOS).1,3 Residual pleomorphic adenoma tissue is identifiable either in its typical morphology, a chondromyxoid stroma, or a hyalinized sclerotic nodule.1 Aside from the type of carcinoma arising from the pleomorphic adenoma, another parameter that has to be reported is the extent of involvement by the carcinomatous component. A carcinoma that is entirely limited to within the parent tumor that is still enclosed by a complete capsule is termed an “intracapsular” or “non-invasive” carcinoma ex pleomorphic adenoma.1,2 Once the carcinoma breaches the capsule and infiltrates the surrounding tissue, then it is considered invasive. If the invasion is less than 4 – 6 mm beyond the capsular border, the tumor is termed “minimally invasive”. Carcinomatous elements that extend beyond this threshold is termed “widely invasive”.1 This threshold is greater than the previous threshold of 1.5 mm recommended in an earlier edition of the WHO classification although the present edition does state that this threshold is preliminary and requires further validation.1,2,4 It has to be pointed out though that quantifying invasion may not always be possible in tumors that have positive margins, those that are intrinsically unencapsulated such as minor salivary gland tumors, and those with complex multinodular growth patterns such as in recurrent pleomorphic adenoma.1 This difficulty has to be stated in the report and what conditions preclude quantifying the degree of invasion. Non-invasive carcinoma ex pleomorphic adenoma has quite a good outcome with very low reported rates of recurrence or regional metastasis. In a review of thirty cases and a report of an additional three cases, only one case showed recurrence or metastasis.3 This favorable outcome certainly contrasts with that of the widely invasive type where metastasis is reported to occur in up to 70% of cases.1 Another review of ten cases showed one case developing metastasis, and recommended that non-invasive cases should thus still be followed up closely after primary treatment because regional or distant metastasis can occur.2 To the best of our knowledge, there are no published local data on the incidence of early malignant transformation of pleomorphic adenomas in the Filipino population. Hence, we take this opportunity to report this case. Awareness of the entity and prudent liberal sampling of these tumors may help address this gap.

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16

Tejendrasingh, Thakur Rahul, and Sonawale Sanjay Kumar Laxmanrao. "Pleomorphic Adenoma of the Nasal Septum." An International Journal of Otorhinolaryngology Clinics 6, no. 1 (2014): 10–12. http://dx.doi.org/10.5005/aijoc-6-1-10.

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ABSTRACT Pleomorphic adenoma is a common, benign tumor arising from the major salivary glands, most commonly from the parotid gland. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual and may be misdiagnosed because they have greater myoepithelial cellularity and fewer myxoid stromata compared to those elsewhere. We report a case of pleomorphic adenoma of the nasal cavity arising from the nasal septum.

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17

Beckmann, Sven, Matthias S. Dettmer, Marco D. Caversaccio, Roland Giger, and Lukas Anschuetz. "Pleomorphic Adenoma of External Auditory Canal: Case Report of First Endoscopic Resection and Literature Review." Medicina 56, no. 5 (May 20, 2020): 248. http://dx.doi.org/10.3390/medicina56050248.

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Ceruminous pleomorphic adenoma is a very rare, mostly benign tumor originating from the ceruminal glands in the external auditory canal. Histologically, it is a mixed tumor with epithelial and stromal parts of different proportions, and is recognized today by the World Health Organization (WHO) as a ceruminous adenoma. Similar to the pleomorphic adenoma of salivary glands, recurrence or malignant degeneration with cellular atypia and metastasis can occur on rare occasions. Here, we describe an 87-year old female patient with a growing spherical mass in the right external auditory canal. After exclusive endoscopic tumor resection, a ceruminous pleomorphic adenoma was histologically diagnosed. Due to the absence of nuclear pleomorphism, no increased mitotic rate, no perineural invasion and no fusion transcripts of the MYB or MYBL1 gene loci, an adenoid cystic carcinoma could be excluded. The postoperative course was without any evidence of complications. A literature review identified 44 articles with 49 patients that were considered. Hearing loss and ear sensations were the most commonly reported symptoms. Most cases underwent an excision via an endaural or retroauricular approach. Recurrences were described in four patients, three of which had a malignant transformation.

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18

DeRoche, Tom C., Aaron P. Hoschar, and Jennifer L. Hunt. "Immunohistochemical Evaluation of Androgen Receptor, HER-2/neu, and p53 in Benign Pleomorphic Adenomas." Archives of Pathology & Laboratory Medicine 132, no. 12 (December 1, 2008): 1907–11. http://dx.doi.org/10.5858/132.12.1907.

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Abstract Context.—Immunohistochemical stains for androgen receptor (AR), HER-2/neu, and p53 are used as diagnostic markers associated with malignancy in several histologic types of salivary gland tumors. These markers may be useful in differentiating pleomorphic adenoma with cytologic atypia from intracapsular carcinoma ex pleomorphic adenoma (CXPA), as these tumors are often difficult to distinguish on the basis of morphology alone. Objective.—To determine whether AR, HER-2/neu, and p53 expression can be seen in entirely benign pleomorphic adenomas. Design.—Androgen receptor, HER-2/neu, and p53 immunoreactivity was assessed in 41 histologically and clinically benign pleomorphic adenomas. Results.—A total of 3 of 41 pleomorphic adenomas exhibited multifocal areas with moderate staining for HER-2/ neu and AR. The positive staining was mainly confined to the epithelial component, where the ductal epithelium showed no cytologic atypia. Immunoreactivity for p53 was observed in the epithelial component of 5 of 41 cases, none of which stained for HER-2/neu and AR. Mean mitotic rate and Ki-67 index were 1 per 10 high-powered fields and 2.7% in HER-2/neu– and AR-positive cases and 1 per 10 high-powered fields and 2.2% in p53-positive cases. Conclusions.—HER-2/neu, AR, and p53 are expressed in a subset of histologically and clinically benign pleomorphic adenomas. These markers cannot be used to reliably predict early carcinomatous transformation in pleomorphic adenoma.

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19

von Holstein, Sarah L., André Fehr, Marta Persson, Marie Nickelsen, Marianne H. Therkildsen, Jan U. Prause, Steffen Heegaard, and Göran Stenman. "Lacrimal Gland Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma." Ophthalmology 121, no. 5 (May 2014): 1125–33. http://dx.doi.org/10.1016/j.ophtha.2013.11.037.

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20

Munish, Kanika, Sneha Vishwasrao Wadhera, Rani Bansal, and Mamta Gupta. "Pleomorphic Adenoma of Salivary Glands:." Indian Journal of Pathology: Research and Practice 7, no. 5 (2018): 634–38. http://dx.doi.org/10.21088/ijprp.2278.148x.7518.10.

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21

Chow, Louis T. C., and W. H. Chow. "Co-existing pleomorphic and tubular basal cell adenomas of the parotid gland." Journal of Laryngology & Otology 111, no. 2 (February 1997): 182–85. http://dx.doi.org/10.1017/s0022215100136801.

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AbstractWe report a hitherto undescribed case of co-existence of a pleomorphic adenoma and a tubular basal cell adenoma affecting the superficial lobe of the left parotid gland of a 53-year-old man. The histology of the pleomorphic adenoma is also of interest in that the prominent adipose metaplasia of its myxoid stroma yielded an appearance reminiscent of myxoid lipoma. The tubular basal cell adenoma showed gross cystic change, and its solid portion consisted of closely packed tubules lined by double layers of cuboidal cells with little intervening stroma. Unlike Warthin's tumour and membranous basal cell adenoma, both pleomorphic and tubular basal cell adenomas exhibit no propensity towards multicentricity or bilaterality. We, therefore, believe that their co-existence in the superficial lobe of the parotid gland of our patient is a mere concidence rather than association.

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22

YAMAMOTO, YUZO. "Pleomorphic adenoma and adenoid cystic carcinoma." Practica Oto-Rhino-Laryngologica 83, no. 4 (1990): 682–83. http://dx.doi.org/10.5631/jibirin.83.682.

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23

Chavan, Shrinivas S., KS Bhople, Jeevan N. Vedi, Prateek V. Jain, and Mangala Sonavani. "Giant Intranasal Pleomorphic Adenoma: A Rare Case Report." An International Journal Clinical Rhinology 6, no. 2 (2013): 96–99. http://dx.doi.org/10.5005/jp-journals-10013-1162.

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ABSTRACT Pleomorphic adenoma, a heterogeneous mixture of epithelial and myoepithelial cells, commonly found in major salivary glands, accounts for about 3% of benign head and neck tumors. Intranasal pleomorphic adenoma (INPA) is an extremely rare variant forming a mere 8% of all pleomorphic adenomas. Majority of these arise from the nasal septum (82-90%) with only about 8% showing attachment to the lateral nasal wall. Various theories explaining etiopathological basis of INPA have been proposed but none explains its predominance in females in 3rd to 6th decade of life. Hallmark of histopathological picture of pleomorphic adenoma is epithelial tissue mixed with tissues of myxoid, chondroid or mucoid origin. But INPA shows predominantly epithelial component with scanty stroma. Considering its high cellularity and anatomical site, INPA is often misdiagnosed as unilateral nasal malignancy. Early diagnosis ensures complete excision and is paramount to make patient disease free, considering its high potential of recurrence. Hereby, we are presenting a case of giant pleomorphic adenoma of nasal cavity, arising from lateral nasal wall, causing erosion of the base of skull, with the intent of drawing attention to this rare diagnosis. How to cite this article Chavan SS, Bhople KS, Vedi JN, Jain PV, Sonavani M. Giant Intranasal Pleomorphic Adenoma: A Rare Case Report. Clin Rhinol An Int J 2013;6(2):96-99.

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Brodetskyi, I. S., V. A. Malanchuk, and V. E. Dosenko. "USE OF 29A MICRO-RNA FOR DIAGNOSIS OF PLEOMORPHIC ADENOMAS OF SALIVARY GLANDS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 1 (April 9, 2020): 149–54. http://dx.doi.org/10.31718/2077-1096.20.1.149.

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Introduction. Pleomorphic adenoma is known as the most common tumour in salivary glands that makes up 60-90% of all benign tumours of the salivary glands. The modern genetic tendency towards the diagnosis of salivary gland tumours is the study of the role of microRNA molecules, and miRNA-29a in the focus of the great researchers’ interest. It is expressed in 84 % of the pleomorphic adenomas of the salivary glands. Objectives. Determination of expression of miRNA-29a in tissues of pleomorphic adenomas of the large salivary glands that adjacent to the tumour of the tissue of the salivary gland, intact tissue of the salivary gland, was out of touch with the tumour and venous blood. Materials and methods. The study included 20 patients with benign tumours of the large salivary glands (pleomorphic adenomas). The expression of miRNA-29a was evaluated by using reverse transcription and quantitative polymerase chain reaction (qPCR) in real time. Results. The analysis of the level of miRNA-29a expression revealed that among 4 groups of indicators (tumour tissue, tissues adjacent to the tumour salivary gland tissue, intact salivary gland, which was out of touch with the tumour and venous blood) in patients with pleomorphic adenoma of the large salivary gland, the highest expression was noted in the group, where salivary gland tissue was adjacent to the salivary gland tumour (111, 93±56, 97 versus 8,12±4,4). Correlation analysis of patients with pleomorphic adenoma of the large salivary glands with different fragments of tissues samples demonstrated that the expression level of miRNA-29a differed significantly between the groups (adjacent gland - intact salivary tissue). Conclusions. A sufficiently high level of miRNA-29a expression in the tissues of pleomorphic adenoma in the large salivary glands compared with the normal (intact salivary gland tissue), 10 times as much can be used as a genetic marker for verification (identification) of this type of tumours. Studies of biopsy material from patients with pleomorphic adenoma in the large salivary glands at the genetic level (by expression of miRNAs-29a) confirm the need not only in enucleating of the tumour (partial parotidectomy), but also in performing of subtotal resection with removal of salivary gland adjacent to the tumour.

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Patil, Rashmi Mallanagouda, and Anirudha Vasant Kushtagi. "Intranasal Pleomorphic Adenoma." An International Journal of Otorhinolaryngology Clinics 5, no. 3 (2013): 164–65. http://dx.doi.org/10.5005/jp-journals-10003-1135.

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ABSTRACT Pleomorphic adenoma is a benign tumor arising from major salivary glands and also has been reported in salivary glands of palate rarely in nasopharynx, oropharynx and larynx and lacrimal glands. We report a case pleomorphic adenoma of nasal septum and discuss the clinical features, management along with review of literature. How to cite this article Patil VM, Patil RM, Kushtagi AV. Intranasal Pleomorphic Adenoma. Int J Otorhinolaryngol Clin 2013;5(3):164-165.

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Patil, Rashmi Mallanagouda, and Anirudha Vasant Kushtagi. "Intranasal Pleomorphic Adenoma." An International Journal of Otorhinolaryngology Clinics 6, no. 3 (2014): 17–18. http://dx.doi.org/10.5005/aijoc-6-3-17.

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ABSTRACT Pleomorphic adenoma is a benign tumor arising from major salivary glands and also has been reported in salivary glands of palate rarely in nasopharynx, oropharynx and larynx and lacrimal glands. We report a case pleomorphic adenoma of nasal septum and discuss the clinical features, management along with review of literature.

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27

Rao, PrasannaKumar, Divya Hegde, and ShishirRam Shetty. "Ectopic pleomorphic adenoma." North American Journal of Medical Sciences 4, no. 4 (2012): 190. http://dx.doi.org/10.4103/1947-2714.94947.

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Jackson, S. R., N. J. Roland, R. W. Clarke, and A. S. Jones. "Recurrent pleomorphic adenoma." Journal of Laryngology & Otology 107, no. 6 (June 1993): 546–49. http://dx.doi.org/10.1017/s0022215100123667.

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Of 209 cases of pleomorphic adenoma treated in a 30 year period, 38 were secondary referrals with recurrent disease following surgery. Of these, 25 were women and 13 men with a mean time to recurrence of 9 years 4 months. Thirty-four recurrences were in the parotid gland. three in the submandibular gland and one in the anterior faucial pillar.Seven patients were untreated due to poor general condition or refusal of further treatment. Of the remainder, 15 had superficial parotidectomy and excision of the scar and nine a total parotidectonly. Three of these had extensive surgery with local flap repair. Of the patients with submandibular gland recurrence, two had local excision and one was treated with radiotherapy alone. One patient had a recurrence in the laucial pillar. Three patients developed malignant change in the recurrent tumour. of whom one died of disease.

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Wasserman, Jason K., Brendan C. Dickson, Adam Smith, David Swanson, Bibianna M. Purgina, and Ilan Weinreb. "Metastasizing Pleomorphic Adenoma." American Journal of Surgical Pathology 43, no. 8 (August 2019): 1145–51. http://dx.doi.org/10.1097/pas.0000000000001280.

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Hayashi, Hisamitsu, and Masaya Kato. "Intranasal Pleomorphic Adenoma." Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology) 42, no. 1 (2003): 18–22. http://dx.doi.org/10.7248/jjrhi1982.42.1_18.

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Mustafaev, D. M. "Laryngeal pleomorphic adenoma." Vestnik otorinolaringologii 82, no. 3 (2017): 66. http://dx.doi.org/10.17116/otorino201782366-68.

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McGurk, M. "Parotid pleomorphic adenoma." British Journal of Surgery 84, no. 11 (November 1997): 1491–92. http://dx.doi.org/10.1002/bjs.1800841103.

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Ali, Syed Rizwan, Andrea Valeria Arrossi, Atul C. Mehta, Laura Frye, Peter Mazzone, and Francisco Almeida. "Endobronchial pleomorphic adenoma." Oxford Medical Case Reports 2016, no. 12 (November 30, 2016): omw090. http://dx.doi.org/10.1093/omcr/omw090.

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Werner, Rachel L., and James T. Castle. "Recurrent Pleomorphic Adenoma." Head and Neck Pathology 8, no. 3 (November 7, 2013): 303–6. http://dx.doi.org/10.1007/s12105-013-0504-6.

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Hatua, N. R., A. K. Banerjee, B. K. Roy, and R. N. Banerjee. "Parapharyngeal pleomorphic adenoma." Indian Journal of Otolaryngology 37, no. 1 (March 1985): 19–20. http://dx.doi.org/10.1007/bf02994943.

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Forde, C. T., R. Millard, and S. Ali. "Soft Palate Pleomorphic Adenoma of a Minor Salivary Gland: An Unusual Presentation." Case Reports in Otolaryngology 2018 (2018): 1–4. http://dx.doi.org/10.1155/2018/3986098.

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Approximately 10% of pleomorphic adenomas occur in the minor salivary glands with the palate being the most common site. Pleomorphic adenomas account for the majority of palatal tumours; however, minor salivary gland tumours have a higher risk of malignancy compared to tumours of the major salivary glands, so appropriate diagnostic evaluation should be prompt. We present a case of a 52-year-old man with a longstanding history of a soft palate pleomorphic adenoma which required excision under general anaesthetic via a mandibular swing approach. As well as the surgical approach to access this tumour; this case is unique as it is the largest soft palate pleomorphic adenoma reported in the literature. We discuss the appropriate preoperative investigations and airway considerations for this patient, as well as the factors to consider when planning operative management of palatal tumours.

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Egal, Erika, Beatriz de Brito, Natália Giovanelli, Harim dos Santos, Rogério Gondak, Oslei Almeida, Luiz Paulo Kowalski, Fernanda Mariano, and Albina Altemani. "PLAG1 Expression From Pleomorphic Adenoma to Carcinoma Ex-Pleomorphic Adenoma." American Journal of Clinical Pathology 144, suppl 2 (October 1, 2015): A284. http://dx.doi.org/10.1093/ajcp/144.suppl2.284.

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Tarakji, Bassel, Omar Kujan, and Mohammad Z. Nassani. "Immunohistochemical Expression of p53 in Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma." Journal of Cancer Epidemiology 2010 (2010): 1–8. http://dx.doi.org/10.1155/2010/250606.

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Context. Immunohistochemical stains for p53 are used as a diagnostic marker associated with malignancy in several histologic types of salivary gland tumors. This marker may be useful in differentiating pleomorphic adenoma (PA) from carcinoma ex pleomorphic adenoma (CPA), as these tumors are often difficult to distinguish on the basis of morphology alone.Objective. to evaluate whatever inactivation of tumor suppressor gene (p53) increases with the tumor progression from normal salivary tissue to PA and eventually CPA.Design. Paraffin blocks of 29 cases of PA, which were surrounded by normal parotid gland, and 27 cases of carcinoma ex pleomorphic adenoma were retrieved and validated. In all cases of carcinoma ex pleomorphic adenoma, a PA “ghost” was identified, and the malignant element was either undifferentiated carcinoma or adenocarcinoma.Results. The results showed negative nuclear expression of P53 in normal parotid gland. Nuclear P53 was expressed strongly in 6/29 (20.7%) pleomorphic salivary adenoma and 10/27 (37%) carcinoma ex pleomorphic adenoma.Conclusion. Our data suggest that inactivation of p53 may play an important role in the evolution of pleomorphic salivary adenoma and carcinoma ex pleomorphic adenoma.

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YOSHIKAWA, Fumihiro, Souichi IWAI, Yuriko TSUBAKIMOTO, Itsuro KATO, Masatoshi OHMAE, Toshihide Doi, and Masayoshi SAKUDA. "A comparative study of clinical features of pleomorphic adenoma and malignant pleomorphic adenoma (carcinoma in pleomorphic adenoma)." Japanese Journal of Oral & Maxillofacial Surgery 42, no. 6 (1996): 590–92. http://dx.doi.org/10.5794/jjoms.42.590.

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Hudson, Jena B., and Brian T. Collins. "MYB Gene Abnormalities t(6;9) in Adenoid Cystic Carcinoma Fine-Needle Aspiration Biopsy Using Fluorescence In Situ Hybridization." Archives of Pathology & Laboratory Medicine 138, no. 3 (March 1, 2014): 403–9. http://dx.doi.org/10.5858/arpa.2012-0736-oa.

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Context.—Fine-needle aspiration (FNA) biopsy of salivary gland neoplasms can have a variety of overlapping appearances. Basaloid neoplasms can be a diagnostic challenge, and FNA cytomorphology alone cannot always provide a definitive diagnosis. Objective.—To examine the incidence and potential utility of detecting a MYB translocation by fluorescence in situ hybridization (FISH) in adenoid cystic carcinomas (AdCCs) and pleomorphic adenoma FNA smears with known surgical outcomes. Design.—Patients who underwent FNA biopsy for surgically confirmed AdCCs and pleomorphic adenomas were identified. Fluorescence in situ hybridization, using commercially available fluorescent-labeled probes, hybridizing to MYB-telomeric and MYB-centromeric, was used to identify the MYB gene and to evaluate it for abnormalities and translocation. Using a fluorescent microscope, 4′,6-diamidino-2-phenylindole (DAPI)-stained, nonoverlapping cells were counted, and 10% or greater abnormal cells were considered positive. Results.—The 10 AdCC and 13 pleomorphic adenoma FNA cases had FISH evaluations performed; 50% (5 of 10) of the AdCC cases showed a MYB abnormality by FISH; 40% (4 of 10) AdCCs showed a positive break-apart signal in most cells (48%–84%). One case (10%) of AdCC showed a trisomy MYB signal pattern without the break-apart translocation pattern. Of the 13 pleomorphic adenomas, none (0%) of the cases showed a MYB translocation or abnormality by FISH. MYB FISH abnormalities showed a 100% positive predictive value, 50% sensitivity, and 100% specificity, when differentiating AdCC from pleomorphic adenoma. Conclusions.— MYB gene abnormalities were present in 50% (5 of 10) of the AdCC cases. This corresponds to the reported prevalence in formalin-fixed, paraffin-embedded tissue for AdCC surgical resections. Using FISH testing for detecting MYB gene abnormalities in the salivary gland of FNA biopsies has the potential to provide additional, helpful ancillary information in diagnosing AdCC.

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Takahashi, Satoshi, Shuji Mikami, Takekazu Akiyama, and Takeshi Kawase. "Intrasellar Salivary Gland-Like Pleomorphic Adenoma." Neurosurgery 68, no. 2 (February 1, 2011): E562—E566. http://dx.doi.org/10.1227/neu.0b013e3182020856.

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Abstract BACKGROUND AND IMPORTANCE: We present a rare case of a patient with intrasellar salivary gland-like pleomorphic adenoma and review the 2 previously reported cases of the clinical entity to identify their common clinical features. CLINICAL PRESENTATION: A 56-year-old Asian man visited our hospital with a chief complaint of visual disturbance caused by brain tumor that filled up the sella turcica with suprasellar extension. The patient underwent craniotomy via a left pterional approach, and the subdural, intracranial portion of the tumor was totally removed, with every artery and nerve preserved. Pathological diagnosis of the tumor was intrasellar salivary gland-like pleomorphic adenoma. Three years after the operation, the patient remains free from tumor recurrence. CONCLUSION: Tumors in all 3 reported cases of intrasellar salivary gland-like pleomorphic adenoma, including the present case, showed suprasellar extension and compressed optic chiasm that resulted in visual disturbance of the patients. A calcified region inside the tumor on computed tomographic scanning was also a common finding. Differential diagnosis of intrasellar salivary gland-like pleomorphic adenomas should be considered in patients with calcified intrasellar tumors with suprasellar extension. The clinical entity seems to show good prognosis if surgically removed.

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Brodetskyi, Igor S., Olena O. Dyadyk, Vladislav A. Malanchuk, Mykhailo S. Myroshnychenko, and Mykhailo S. Krotevych. "IMMUNOHISTOCHEMICAL FEATURES OF THE EXPRESSION OF HUMAN PAPILLOMA VIRUS TYPE 16 IN PLEOMORPHIC ADENOMAS OF SALIVARY GLAND." Wiadomości Lekarskie 74, no. 1 (January 2021): 7–10. http://dx.doi.org/10.36740/wlek202101101.

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The aim is to reveal the immunohistochemical features of human papilloma virus type 16 expression in various histological variants of pleomorphic adenomas of the salivary gland. Materials and methods: The material of the study was surgical and biopsy material from 30 patients with pleomorphic adenomas of the salivary glands, among which in 15 cases mesenchymal was detected, in 10 – mixed, in 5 cases – epithelial histological variant, respectively. Immunohistochemical study was performed, using mouse monoclonal antibody to human papilloma virus type 16. Visualization was performed, using an EnVisionTM FLEX detection system. Histological sections of grade III cervical intraepithelial neoplasia (CIN III) were used as a positive control; for a negative control, the procedure was performed without primary antibodies. The immunohistochemical reaction was assessed by a semi-quantitative method by counting the percentage of positively stained cells in the field of view of a microscope × 400. Microspecimens were studied, photoarchived on an Olympus BX-41 microscope. Results: Expression of human papilloma virus type 16 of varying severity was determined in 26 cases of pleomorphic adenomas of the salivary glands, which was 86.7%. The epithelial component of the pleomorphic adenoma of the salivary gland was characterized by a more pronounced expression of the monoclonal antibody to human papilloma virus type 16 compared to the mesenchymal component of the tumor. The severity of the immunohistochemical reaction with a monoclonal antibody to human papilloma virus type 16 depended on the histological variant of the pleomorphic adenoma of the salivary gland. Epithelial, mixed and mesenchymal variants of pleomorphic adenoma of the salivary gland were characterized, respectively, by the most pronounced, pronounced and moderately pronounced expression of a monoclonal antibody to human papilloma virus type 16. Conclusions: A comprehensive immunohistochemical study with a monoclonal antibody to human papilloma virus type 16 revealed the presence of a causal relationship between the infection of a patient with human papilloma virus type 16 and development of pleomorphic adenoma of the salivary gland in him.

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Gabelloni, Michela, Lorenzo Faggioni, Simona Attanasio, Vanina Vani, Antonio Goddi, Sara Colantonio, Danila Germanese, et al. "Can Magnetic Resonance Radiomics Analysis Discriminate Parotid Gland Tumors? A Pilot Study." Diagnostics 10, no. 11 (November 3, 2020): 900. http://dx.doi.org/10.3390/diagnostics10110900.

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Our purpose is to evaluate the performance of magnetic resonance (MR) radiomics analysis for differentiating between malignant and benign parotid neoplasms and, among the latter, between pleomorphic adenomas and Warthin tumors. We retrospectively evaluated 75 T2-weighted images of parotid gland lesions, of which 61 were benign tumors (32 pleomorphic adenomas, 23 Warthin tumors and 6 oncocytomas) and 14 were malignant tumors. A receiver operating characteristics (ROC) curve analysis was performed to find the threshold values for the most discriminative features and determine their sensitivity, specificity and area under the ROC curve (AUROC). The most discriminative features were used to train a support vector machine classifier. The best classification performance was obtained by comparing a pleomorphic adenoma with a Warthin tumor (yielding sensitivity, specificity and a diagnostic accuracy as high as 0.8695, 0.9062 and 0.8909, respectively) and a pleomorphic adenoma with malignant tumors (sensitivity, specificity and a diagnostic accuracy of 0.6666, 0.8709 and 0.8043, respectively). Radiomics analysis of parotid tumors on conventional T2-weighted MR images allows the discrimination of pleomorphic adenomas from Warthin tumors and malignant tumors with a high sensitivity, specificity and diagnostic accuracy.

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Bhardwaj, Aparna, and Sonam Rathi. "Pleomorphic Adenoma of the Lateral Nasal Wall: An Unusual Entity." An International Journal Clinical Rhinology 9, no. 3 (2016): 146–48. http://dx.doi.org/10.5005/jp-journals-10013-1290.

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ABSTRACT Pleomorphic adenomas occurring in the nasal cavity are rarely encountered; nevertheless, there is abundance of minor seromucinous glands in that region. Most cases present with a painless, slowly progressing unilateral nasal obstruction, a nasal mass, and epistaxis. Herewith, we present an unusual case of pleomorphic adenoma arising from the lateral wall of the right nasal cavity in a 41-year-old male who complained of right nasal obstruction with no history of epistaxis. Rigid nasal endoscopy revealed a swelling continuous with right inferior concha. Computed tomography showed a well-defined, soft tissue mass in the right nasal cavity. The lesion was completely excised endoscopically. Histopathology confirmed a pleomorphic adenoma consisting of epithelial and mesenchymal elements. Wide exposure is crucial for complete excision with negative margins to achieve positive outcome and to prevent recurrence. How to cite this article Pandey AK, Bhardwaj A, Maithani T, Rathi S. Pleomorphic Adenoma of the Lateral Nasal Wall: An Unusual Entity. Clin Rhinol An Int J 2016;9(3):146-148.

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Bhardwaj, Aparna, and Sonam Rathi. "Pleomorphic Adenoma of the Lateral Nasal Wall: An Unusual Entity." An International Journal Clinical Rhinology 10, no. 1 (2017): 11–13. http://dx.doi.org/10.5005/jp-journals-10013-1295.

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ABSTRACT Pleomorphic adenomas occurring in the nasal cavity are rarely encountered; nevertheless, the abundance of minor seromucinous glands in that region is seen. Most cases present with a painless, slowly progressing unilateral nasal obstruction, a nasal mass, and epistaxis. Herewith, we present an unusual case of pleomorphic adenoma arising from the lateral wall of right nasal cavity in a 41-year-old male, who complained of right nasal obstruction with no history of epistaxis. Rigid nasal endoscopy revealed a swelling continuous with right inferior concha. Computed tomography showed a well-defined, soft tissue mass in the right nasal cavity. The lesion was completely excised endoscopically. Histopathology confirmed a pleomorphic adenoma consisting of epithelial and mesenchymal elements. Wide exposure is crucial for complete excision with negative margins to achieve positive outcome and to prevent recurrence. How to cite this article Pandey AK, Bhardwaj A, Maithani T, Rathi S. Pleomorphic Adenoma of the Lateral Nasal Wall: An Unusual Entity. Clin Rhinol An Int J 2017;10(1):11-13.

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Kaza, Suma, T. Jaya Mastan Rao, Anupama Mikkilineni, G. Venkata Ratnam, and D. Ranga Rao. "Ki-67 Index in Salivary Gland Neoplasms." International Journal of Phonosurgery & Laryngology 6, no. 1 (2016): 1–7. http://dx.doi.org/10.5005/jp-journals-10023-1110.

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Abstract Assessment of proliferation is a means of predicting local recurrence and metastatic potential of malignancies. A mitotic count is not an ideal marker for proliferation in certain situations, such as salivary gland neoplasms. Ki-67 expression as a proliferation marker has been investigated in many human tumors. In the present study, Mitotic index (MI) and Ki-67 index were studied in pleomorphic adenoma, basal cell adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma epithelial myoepithelial carcinoma, carcinoma ex Pleomorphic adenoma and adenocarcinoma of salivary glands. The results were compared. The MI was similar in benign neoplasms, mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, whereas it was high in carcinoma ex pleomorphic adenoma, adenocarcinoma and adenoid cystic carcinoma. The Ki-67 index was different in basal cell adenoma and pleomorphic adenoma. It was helpful in differentiating high grade and low grade mucoepidermoid carcinoma. It highlighted the malignant behavior of epithelial myoepithelial carcinoma. It was concluded that Ki-67 in benign neoplasms is 5% or less and in malignant ones more than 23% with a few exceptions. In mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, Ki-67 index was found to be a better indicator for aggressiveness. These findings will be presented in this paper, with review of literature. How to cite this article Kaza S, Rao TJM, Mikkilineni A, Ratnam GV, Rao DR. Ki-67 Index in Salivary Gland Neoplasms. Int J Phonosurg Laryngol 2016;6(1):1-7.

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Badia, Lydia, Justin N. Weir, and Anthony C. Robinson. "Heterotopic pleomorphic adenoma of the external nose." Journal of Laryngology & Otology 110, no. 4 (April 1996): 376–78. http://dx.doi.org/10.1017/s0022215100133675.

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AbstractPleomorphic adenomas arising from sites other than the major or minor salivary glands are uncommon. We describe a case of pleomorphic adenoma in the subcutaneous tissue of the nasomaxillary crease. An identical tumour was previously excised from the right nasal cavity. The possible aetiology of these heterotopic salivary gland tumours is discussed.

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Mariano, Fernanda Viviane, Ana Flávia Costa, Rogério Oliveira Gondak, Antonio Santos Martins, André Del Negro, Álfio José Tincani, Albina Altemani, Oslei Paes de Almeida, and Luiz Paulo Kowalski. "Cellular Proliferation Index between Carcinoma Ex-Pleomorphic Adenoma and Pleomorphic Adenoma." Brazilian Dental Journal 26, no. 4 (August 2015): 416–21. http://dx.doi.org/10.1590/0103-6440201300369.

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<p>Carcinoma ex pleomorphic adenoma (CXPA) has been considered an interesting model of carcinogenesis, presenting various histological subtypes and invasiveness phase. The objective was to determine the proliferative index of CXPA and comparing to pleomorphic adenoma (PA). Thirty six cases of CXPA (36 PA) and 22 areas of PA in CXPA (residual PA) were studied by Ki-67 expression. All CXPA cases were classified according to invasiveness phase (intracapsular, minimally and frankly invasive) and histopathological subtypes. Data was statistically analyzed by Wilcoxon, Mann-Whitney and Kruskal-Wallis tests. CXPA included 5 intracapsular, 9 minimally invasive and 22 frankly invasive cases. Fifteen cases corresponded to salivary duct carcinoma, 7 to adenocarcinoma NOS, 7 myoepithelial, 5 epithelial-myoepithelial, one case of squamous cell and one case of sarcomatoid carcinoma. The Ki-67 index of PA and residual PA were significantly lower than CXPA. Intracapsular and minimally invasive showed smaller proliferative index than frankly invasive. Considering the subtypes of CXPA, there was not a statistic difference among them. Ki-67 is a useful marker in the differential diagnosis of PA and CXPA, even when in the early invasive phase.</p>

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Mariano, Fernanda Viviane, Felipe Fidalgo, André Luís Maion Casarim, Antônio Santos Martins, João Figueira Scarini, Reydson Alcides de Lima Souza, Erika Said Egal, Luiz Paulo Kowalski, Ana Cristina Victorino Krepischi, and Albina Altemani. "Somatic copy number alterations in pleomorphic adenoma and recurrent pleomorphic adenoma." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 129, no. 1 (January 2020): 59–64. http://dx.doi.org/10.1016/j.oooo.2019.08.016.

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Pingarrón-Martín, Lorena, L. J. Arias-Gallo, G. Demaría-Martínez, and M. Chamorro Pons. "Remarkable Triple Pleomorphic Adenoma Affecting both Parotid and Submandibular Glands." Craniomaxillofacial Trauma & Reconstruction 8, no. 2 (June 2015): 129–31. http://dx.doi.org/10.1055/s-0034-1378184.

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The objective of this article is to present the first case reported in the literature of metachronous pleomorphic adenoma of bilateral parotid glands and submaxillary gland. The authors report the case of a 27-year-old female with metachronous mixed tumors in her right parotid and submandibular glands. The patient has no history of previous radiotherapy. All three lesions were diagnosed by fine-needle aspiration. The histopathologic evaluation of all three major salivary gland masses demonstrated pleomorphic adenomas, with no occult malignancy observed on serial sections. The presentation of pleomorphic adenomas in the parotids and submandibular glands probably represents three unrelated primary sites of tumor, yet the possibility of metastasis from one gland to the other cannot be excluded.

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