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Dissertations / Theses on the topic 'Adenosine deaminase and Metabolism'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Wu, Joe. "HIF-1α in the Heart: Provision of Ischemic Cardioprotection and Remodeling of Nucleotide Metabolism". Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etd/2450.

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In our studies we found that stabilized expression of HIF-1α in heart led to better recovery of function and less tissue death after 30 minutes of global ischemia, via mechanisms that preserve the mitochondrial polarization. Our group previously showed that HIF-1α conferred ischemic tolerance by allowing cardiomyocytes to use fumarate as an alternative terminal electron acceptor to sustain anaerobic mitochondrial polarization. The source of fumarate was identified as the purine nucleotide cycle (PNC). Here we discovered that HIF-1α upregulates AMP deaminase 2 (AMPD2), the entry point to the PN

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2

Bona, Karine Santos de. "Efeito do extrato de Syzygium cumini e alterações provocadas pela síndrome metabólica sobre parâmetros bioquímicos e inflamatórios." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/3846.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Metabolic syndrome (MetS) is a complex disorder represented by a set of cardiovascular risk factors, including endothelial dysfunction, oxidative stress and inflammation. Syzygium cumini has hypoglycemic, anti-inflammatory, antipyretic, hypolipidemic and antioxidant properties, besides antiviral and anticarcinogenic action. Considering the importance of MetS in the current economic and social context, morbidity and complications following this pathology, the aim of this study was to assess biochemical and inflammatory parameters in

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3

Abbott, C. M. "Adenosine deaminase in the wasted mouse." Thesis, University of Reading, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374695.

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4

Molaudzi, Mulalo. "The usefulness of the adenosine deaminase assay for diagnosing tuberculosis pleuritis in immunocompromised patients at Dr George Mukhari tertiary laboratory, Pretoria." Thesis, University of Limpopo (Medunsa Campus), 2012. http://hdl.handle.net/10386/671.

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Thesis (MSc (Med)(Microbiology)) -- University of Limpopo, 2012.<br>Mycobacterium tuberculosis is the most common cause of death world-wide and its incidence has been steadily increasing, which is more evident when comparing the global tuberculosis (T8) incidence of 9.24 million in 2006 to 9.27 million cases in 2007. African countries are the second most affected by the epidemic and South Africa is among the 22 highest burden countries most affected by T8 with a very high number of cases relative to the total population. The early diagnosis of tuberculosis and screening of contacts is the corn

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5

SIGNA, SARA. "NETosis Dysregulation in Adenosine Deaminase 2 deficiency (DADA2)." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1080132.

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Introduction: Deficiency of Adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disorder presenting a broad spectrum of clinical manifestations, including vasculitis, immunodeficiency and hematologic disease. The genetic mutations in ADA2 gene have been associated to an insufficient ADA2 activity leading to reduction in deamination of adenosine to deoxyadenosine, and a consequent accumulation of extracellular adenosine. The pathogenic mechanisms investigated so far have elucidated a skewed polarization from the M2 macrophage subtype to the proinflammatory M1 subtype with an increased

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6

Dinjens, Winandus Nicolaas Maria. "Distribution of adenosine deaminase complexing protein in normal and neoplastic cells." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1988. http://arno.unimaas.nl/show.cgi?fid=5412.

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7

Björkegren, Emma Katia Madeleine. "Development of gene therapy for the treatment of adenosine deaminase deficiency." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444352/.

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Adenosine deaminase (ADA) severe combined immunodeficiency (SCED) is a life-threatening condition resulting from lack of the ADA enzyme. Consequences include immunodeficiency and non-immunological symptoms such as neurological abnormalities. Bone marrow transplantation (BMT) from a haploidentical donor usually results in complete restoration of immune function. However, the majority of patients do not have a matched donor and are therefore treated with enzyme replacement therapy (PEG-ADA). This treatment is not always fully effective, it is expensive and needs to be administered throughout lif

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8

Samee, Abdus. "An analysis of the ADAT1 (adenosine deaminase, tRNA- specific 1) gene in cancer." Thesis, Keele University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.530765.

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9

Svenningsson, Per. "Striatal adenosine A₂A receptors /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19981015sven.

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10

Voigt, Michael D. "The diagnostic value of adenosine deaminase activity in the ascitic fluid of patients with tuberculous peritonitis." Master's thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/25882.

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This study was designed to: 1. Examine the diagnostic value of ADA levels in ascitic fluid, 2. Establish the sensitivity and specificity of this test in the diagnosis of tuberculous peritonitis, in a large number of patients, 3. Establish levels of adenosine deaminase activity which give the best discriminatory information in patients with ascites. 4. Determine what conditions may give rise to false positive or false negative results. 5. Finally, the study was designed to assess the relative diagnostic accuracy of previously used biochemical and haematological data, such as ascites total prote

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11

Willems, Laura E., and n/a. "Adenosine and Ischaemia in Young To Aged Hearts." Griffith University. School of Medical Science, 2006. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20061011.163451.

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Ischaemic heart disease is a major contributor to premature death and heart failure in the Westernised world. Ischaemic injury within the heart may be beneficially modulated by the nucleoside adenosine. Derived from catabolism of ATP, adenosine was initially known as a potent bradycardic and hypotensive agent. However, more recently the protective function of adenosine has been investigated. The protective effects of adenosine are mediated via activation of adenosine receptors: A1, A2A, A2B, and A3 receptors. Activation of these potentially protective (or retaliatory) adenosine receptors hinge

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12

Willems, Laura E. "Adenosine and Ischaemia in Young To Aged Hearts." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/365196.

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Ischaemic heart disease is a major contributor to premature death and heart failure in the Westernised world. Ischaemic injury within the heart may be beneficially modulated by the nucleoside adenosine. Derived from catabolism of ATP, adenosine was initially known as a potent bradycardic and hypotensive agent. However, more recently the protective function of adenosine has been investigated. The protective effects of adenosine are mediated via activation of adenosine receptors: A1, A2A, A2B, and A3 receptors. Activation of these potentially protective (or retaliatory) adenosine receptors hinge

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13

Cavalcante, Ãtalo JosÃ Mesquita. "Aspectos epidemiolÃgicos da leishmaniose visceral no Brasil de 2001 a 2011, no estado do CearÃ de 2007 a 2011 e perfil da adenosina desaminase em pacientes acometidos pela doenÃa." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12954.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>IntroduÃÃo: A leishmaniose visceral (LV) Ã uma doenÃa causada por protozoÃrios do gÃnero Leishmania e transmitida por insetos flebotomÃneos. O Brasil Ã uma das mais importantes Ãreas endÃmicas para a doenÃa, sendo necessÃrio o acompanhamento da ocorrÃncia dos casos atravÃs de uma vigilÃncia epidemiolÃgica ativa. A adenosina desaminase (ADA) Ã uma enzima que catalisa a desaminaÃÃo da adenosina produzindo inosina e amÃnia. Em humanos, estÃ presente como duas isoenzimas e trÃs isoformas (ADA1, ADA1-CD26 e ADA2), sendo fundamental para

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14

Solari, L., der Stuyft P. Van, and Alonso Soto. "Development of a clinical prediction rule for tuberculous meningitis in adults in Lima, Peru." Blackwell Publishing Ltd, 2018. http://hdl.handle.net/10757/624693.

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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.<br>Objectives: Diagnosis of tuberculous meningitis (TM) is a challenge in countries with a high burden of the disease and constrained resources and clinical prediction rules (CPRs) could be of assistance. We aimed at developing a CPR for diagnosis of TM in a Latin American setting with high tuberculosis incidence and a concentrated HIV epidemic. Methods: We enrolled adult patients with clinical suspicion of TM attending two hospitals in Lima, Peru

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15

Roura, Frigolé Helena. "Biomedical studies of human adenosine deaminase acting on transfer RNA and related therapeutic strategies." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/650900.

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Adenosine deaminase acting on transfer RNA (ADAT) is a human heterodimeric enzyme that catalyzes the deamination of adenosine (A) to inosine (I) at the first position of the anticodon of transfer RNAs (tRNAs) (position 34, or wobble position); one of the few essential post-transcriptional modifications on tRNAs (1-5). Inosine 34 allows the recognition of three different nucleotides: cytidine, uridine and adenosine, at the third position of the codon, thus increasing the decoding capacity of tRNAs to more than one messenger RNA (mRNA) codon (adenosine 34 can in principle only pair with codons w

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16

Singhabahu, S. A. D. Sanjeewa. "Plant-based strategies aimed at expressing a functional human adenosine deaminase at high levels." Thesis, University of East London, 2012. http://roar.uel.ac.uk/1889/.

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An inherited disorder, ADA deficiency, is a form of severe combined immunodeficiency, which is ultimately caused by an absence of adenosine deaminase (ADA), a key enzyme of the purine salvage pathway. The absence of ADA-activity in sufferers eventually results in a dysfunctional immune system due to the build-up of toxic metabolites. To date, this has been treated with mixed success, using PEG-ADA, made from purified bovine ADA coupled to polyethylene glycol. It is likely however, that an enzyme replacement therapy protocol based on recombinant human ADA would be a more effective treatment for

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17

Silva, Aleksandro Schafer da. "Atividade da adenosina desaminase, concentração de nucleotideos e nucleosideo de adenina em ratos Infectados com Trypanosoma evansi." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/4058.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The purinergic system is known to be an important signaling pathway in different tissues. Among the components of this system have adenosine, a modulator of central nervous, circulatory and immune systems. The concentration of adenosine in the host is controlled by the enzyme adenosine deaminase (ADA), present in tissues, cells and fluids. As a result, the objectives of this study were (1) to determine the ADA activity in Trypanosoma evansi, (2) evaluate the activity of ADA in serum, erythrocytes, lymphocytes and brain of infe

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18

Sauls, Bryan Auston. "Integrated modulation of sympathetic tone in the microcirculation by oxygen, adenosine, and nitric oxide." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2025.

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Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains xii, 195 p. : ill. Vita. Includes abstract. Includes bibliographical references.

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19

Bin, Anna. "Metabolismo dell'adenosina: correlazione tra processi biochimici e contrattilità nella muscolatura liscia intestinale in condizioni normali e patologiche." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425111.

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In the gastrointestinal tract continued or repeated exposure to pathogens and non-pathogenic antigens may induce activation of epithelial immune system, potentially through dysregulation of barrier functions (Rijnierse et al., 2007). It is well recognized that an inflammatory response, which is largely restricted to the intestinal mucosa, may cause profound changes in the function of smooth muscle and enteric nerves. Some of these changes also occur at remote non-inflamed sites, producing extensive disturbances in gut physiology (Collins et al., 2001). In the intestine, cyclic AMP has been s

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20

Schwartz, Thomas. "Structural basis for left handed Z-DNA binding by human dsRNA specific adenosine deaminase ADAR1." [S.l.] : [s.n.], 1999. http://www.diss.fu-berlin.de/2000/34/index.html.

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21

Carlos, Carolina Dias. "Polimorfismos nos Receptores de Adenosina, suas Associações com Características Fisiopatológicas e Avaliação de Componentes na Biossíntese da Adenosina em Pacientes com Doença Falciforme." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-12062013-074600/.

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Na Anemia Falciforme em situações de baixa tensão de oxigênio, a hemoglobina mutante S (HbS) sofre polimerização promovendo a falcização das hemácias, que podem aderir ao endotélio vascular, causando a oclusão de vasos (VO) e isquemia tecidual (crises dolorosas) que caracterizam o quadro clínico da doença. Além disso, os pacientes falciformes apresentam outras manifestações clínicas como o priapismo, alterações ósseas, certas complicações pulmonares entre outros. Além das células eritróides, células endoteliais, leucócitos e plaquetas também desempenham um papel fundamental na fisiopatologia d

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22

Großmann, Jenny [Verfasser], and Stefan [Akademischer Betreuer] Bauer. "Die immunregulativen Funktionen von adenosine deaminase acting on RNA 1 (ADAR1) / Jenny Großmann. Betreuer: Stefan Bauer." Marburg : Philipps-Universität Marburg, 2014. http://d-nb.info/1051934702/34.

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23

Wright, Denis Matthew John, and mikewood@deakin edu au. "Potential antiarrhythmic and cardioprotective agents based on adenosine." Deakin University. School of Biological and Chemical Sciences, 1998. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050915.160941.

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N-Ethylcarboxamidoadenosine (12) was synthesised from adenosine (1) and the 6-chloro-2,3-O-isopropylidene-AT-ethylcarboxamidoadenosine (25) was synthesised from inosine (19). Employing molecular modelling techniques and the results from previous structure activity relationships it was possible to design and synthesise a N6-substituted N-ethylcarboxamidoadenosines which possessed an oxygen in the N6-substituent either in the form of an epoxide (which was obtained by cpoxidising an alkene with m-CPBA or dimethyldioxirane) or in the form of a cyclic ether as was the case for N6-((tetrahydro-2H-

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24

Kalsi, Kameljit Kaur. "Nucleotide and adenosine metabolism in heart failure and cardioprotection." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409176.

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25

Khan, Zeenatul. "Adenosine diphosphoribosyl transferase in granulocyte-monocyte differentiation." Thesis, Brunel University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.255772.

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26

Oliveira, Camila Belmonte. "Atividade das enzimas ntpdase, 5´-nucleotidase e adenosina deaminase em plaquetas de ratos infectados por Trypanosoma evansi." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/10079.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Nucleotide- and nucleoside-degrading enzymes are present in the surface of platelets, blood cells involved in clotting disturbances of Trypanosoma evansi-infected animals. Thus, this study was aimed at evaluating the activity of the enzymes NTPDase, 5 - nucleotidase and adenosine deaminase in platelets of rats experimentally infected by T. evansi. Animals were divided into four groups, according to the degree of parasitemia. Samples were collected at days 3 (group A: at the beginning of parasitemia), 5 (group B: high parasite

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27

Kavianipour, Mohammad. "Myocardial energy metabolism in ischemic preconditioning, role of adenosine catabolism." Doctoral thesis, Umeå University, Public Health and Clinical Medicine, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-14.

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<p>Brief episodes of ischemia and reperfusion render the myocardium more resistant to necrosis from a subsequent, otherwise lethal ischemic insult. This phenomenon is called ischemic preconditioning(IP). Today, much is known about the signalling pathways involved in IP; however, the details of the final steps leading to cardioprotection, remain elusive. Adenosine (a catabolite of ATP) plays a major role in the signalling pathways of IP. Following IP there is an unexplained discrepancy between an increased adenosine production (evidenced by increased 5’-nucleotidase activity) and the successive

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Latoscha, Andreas. "Cyclic di-adenosine monophosphate metabolism and functions in Streptomyces venezuelae." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22840.

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Lebewesen nutzen nukleotid-basierte sekundäre Botenstoffe um extra- und intrazelluläre Signale zur Induktion einer entsprechenden Zellantwort weiterzuleiten. Das zyklische Dinukleotid c-di-AMP steuert verschiedene physiologische Prozesse und ist für viele Bakterien unter bestimmten Bedingungen essentiell. Dieses Signalmolekül muss präzise reguliert werden, da seine Akkumulation oft toxisch ist. Diadenylatzyklasen mit einer DAC-Domäne synthetisieren c-di-AMP, welches von Phosphodiesterasen (PDE) mit DHH/DHHA1- oder HD-Domänen abgebaut wird. Streptomyceten sind im Boden lebende, Gram-positive A

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29

Hammarberg, Tove. "5-Lipoxygenase : studies on the active site iron, and on the stimulatory factors Ca2⁺ and ATP /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4387-7/.

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30

Swanepoel, Hendré. "Utility of chloride and adenosine deaminase measurement in cerebrosphinal fluid for the early presumptive diagnosis of tuberculous meningitis." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25438.

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Background: Chloride and adenosine deaminase measurements in cerebrospinal fluid are still sporadically requested as part of tuberculous meningitis work-up. In the literature, evidence is contradictory and opinion is divided on their utility in clinical practice. The accuracy of both for the early presumptive diagnosis of tuberculous meningitis was investigated in patients in a region with high prevalence of tuberculosis and HIV infection in order to inform a decision on whether to continue offering these tests to clinicians. Methods: A retrospective descriptive study of diagnostic accuracy wa

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31

Thomas, Collin Ernest. "Extracellular ATP : transport, metabolism, and physiological significance /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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32

Cervantes-Laurean, Daniel. "Preparation and Characterization of Model Conjugates for the Study of Proteins Modified by ADP-ribose." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc935701/.

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Modification of proteins by ADP-ribose has been shown to be a versatile modification with respect to the amino acid side chain. The results described here will allow the study of the biological importance of ADP-ribose glycation and also allow differentiation on crude extracts between enzymatic modifications from protein ADP-ribose glycation that can occur due to the presence of NAD glycohydrolases.

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Chielle, Eduardo Ottobelli. "EFEITO DA RUTINA SOBRE A ATIVIDADE DA ADENOSINA DEAMINASE EM RATOS DIABÉTICOS." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/5921.

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Diabetes mellitus (DM) is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia resulting from deficiency of insulin production and/or action. This state of hyperglycemia may cause a variety of cardiovascular, renal, neurological and eye complications. Adenosine deaminase (ADA) is an important enzyme responsible for regulation the levels of adenosine (ado) an important component of the system purinergic nucleoside. Changes in ADA activity has been demonstrated in several diseases, including DM. The Rutin (RT) is an abundant polyphenolic flavonoid found in food that e

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Sharma, Ravi Janak. "Uptake and metabolism of circultaing inosine and adenosine in the rat." Thesis, St George's, University of London, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283583.

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Sharma, Ravi Janak. "Uptake and metabolism of circulating inosine and adenosine in the rat." Thesis, St George's, University of London, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295171.

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Syaifudin, Mochamad. "Species-specific DNA markers for improving the genetic management of tilapia." Thesis, University of Stirling, 2015. http://hdl.handle.net/1893/22624.

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The tilapias are a group of African and Middle Eastern cichlid fish that are widely cultured in developed and developing countries. With many different species and sub-species, and extensive use of interspecies hybrids, identification of tilapia species is of importance in aquaculture and in wild populations where introductions occur. This research set out to distinguish between tilapia species and sub-species by retrieving species-specific nuclear DNA markers (SNPs) using two approaches: (i) sequencing of the coding regions of the ADA gene; and (ii) next-generation sequencing, both standard R

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Ribeiro, Cristina Alves. "Amplificação, clonagem, expressão e purificação da enzima adenosina deaminase (ADA) de Tripanosoma evansi." Universidade do Estado de Santa Catarina, 2016. http://tede.udesc.br/handle/handle/2366.

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Submitted by Claudia Rocha (claudia.rocha@udesc.br) on 2018-02-19T14:37:08Z No. of bitstreams: 1 PGCA16MA189.pdf: 195058 bytes, checksum: d718ac1f6d250d64aa0878094047280c (MD5)<br>Made available in DSpace on 2018-02-19T14:37:08Z (GMT). No. of bitstreams: 1 PGCA16MA189.pdf: 195058 bytes, checksum: d718ac1f6d250d64aa0878094047280c (MD5) Previous issue date: 2016-01-26<br>UNIEDU<br>FUMDES<br>T. evansi causes a highly pathogenic disease in horses popularly known as "Surra" or "Mal das Cadeiras". The Pantanal (Brazil) outbreaks are recorded due to the large population of horses. To date there

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Dahlstedt, Anders. "Intracellular mechanisms of skeletal muscle fatigue : role of creatine kinase /." Stockholm : [A. Dahlstedt], 2001. http://diss.kib.ki.se/2001/91-631-1673-1/.

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Barros, Muriel Primon de. "Adenosina deaminase em trichomonas vaginalis : estudo da localização celular e do efeito de nutrientes essenciais." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/85309.

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Trichomonas vaginalis é o protozoário flagelado que parasita o trato urogenital humano causando a tricomonose, doença sexualmente transmissível (DST) de origem não viral mais comum no mundo. Durante a infecção a aquisição de nutrientes, como nucleotídeos púricos, pirimidínicos e ferro é essencial à sobrevivência do parasito. T. vaginalis não sintetiza de novo purinas e pirimidinas, dependendo de vias de salvação para aquisição destas moléculas. O ferro desempenha um papel crucial na patogenicidade da tricomonose, influenciando a expressão de múltiplos genes envolvidos na virulência. Nucleotíde

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Latoscha, Andreas [Verfasser]. "Cyclic di-adenosine monophosphate metabolism and functions in Streptomyces venezuelae / Andreas Latoscha." Berlin : Humboldt-Universität zu Berlin, 2021. http://d-nb.info/1233286005/34.

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41

Ådén, Ulrika. "Adenosine receptors in the immature brain : with special reference to their role in hypoxic ischemia /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4704-x/.

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Shevchenko, Ivan [Verfasser], and Viktor [Akademischer Betreuer] Umansky. "Extracellular adenosine metabolism in melanoma and pancreatic cancer / Ivan Shevchenko ; Betreuer: Viktor Umansky." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177809443/34.

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Cheng, Bo. "Investigation of the control of major enzymes involved in adenosine metabolism in rat skeletal muscle /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20228399.

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Pimentel, Victor Camera. "ATIVIDADE DA ADENOSINA DEAMINASE EM DIFERENTES PERÍODOS APÓS A HIPÓXIA-ISQUEMIA NEONATAL EM CÓRTEX DE RATOS." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/5888.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Neonatal hypoxic-ischemic injury (HI) is the direct complication to severe choking and may cause brain damage. HI may be found in different stages and clinical manifestations contributing to neonatal morbidity and mortality. The neuropathology of neonatal HI insult is multi-factorial and complex. Hypoxic-ischemic brain damage begins during the insult and extends during the recovery period after reperfusion, thus, it is an evolutionary process. Adenosine deaminase (ADA) is an aminohidrolase actively involved in the metabolism of pur

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Cheng, Bo, and 程菠. "Investigation of the control of major enzymes involved in adenosine metabolism in rat skeletal muscle." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31238269.

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Le, Gengyun. "Investigation of the enzymes involved in adenosine metabolism in vascular endothelial cells from rat skeletal muscle." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42182165.

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Domingos, Ana Carolina Bonini [UNESP]. "Avaliação dos polimorfismos nos genes enzima conversora de angiotensina e adenosina deaminase em pacientes com diabetes melito tipo 2." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/92488.

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Made available in DSpace on 2014-06-11T19:26:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-18Bitstream added on 2014-06-13T19:12:50Z : No. of bitstreams: 1 domingos_acb_me_sjrp.pdf: 2339356 bytes, checksum: a0674e0784be91957c9249d57f61d341 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O diabetes melito (DM) é um grupo heterogêneo de alterações metabólicas, caracterizado por hiperglicemia crônica, com alterações do metabolismo de carboidratos, ácidos graxos e proteínas. O diabetes melito tipo 2 (DMT2) é a forma mais comum dessa doença, acomente

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Solari, Lely, Alonso Soto, and der Stuyft Patrick Van. "Performance of clinical prediction rules for diagnosis of pleural tuberculosis in a high-incidence setting." John Wiley & Sons Ltd, 2017. http://hdl.handle.net/10757/622276.

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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.<br>Objectives: Diagnosis of pleural tuberculosis (PT) is still a challenge, particularly in resource-constrained settings. Alternative diagnostic tools are needed. We aimed at evaluating the utility of Clinical Prediction Rules (CPRs) for diagnosis of pleural tuberculosis in Peru. Methods: We identified CPRs for diagnosis of PT through a structured literature search. CPRs using high-complexity tests, as defined by the FDA, were excluded. We applie

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Sinclair, Christopher J. D. "Regulation of extracellular adenosine levels, role of nucleoside transporters, purine metabolism and the blood-brain-barrier." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ62667.pdf.

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Le, Gengyun, and 樂耕耘. "Investigation of the enzymes involved in adenosine metabolism in vascular endothelial cells from rat skeletal muscle." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42182165.

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