Log in

Relevant bibliographies by topics / Adenosine-signalling / Journal articles

To see the other types of publications on this topic, follow the link: Adenosine-signalling.

Journal articles on the topic 'Adenosine-signalling'

Author: Grafiati

Published: 14 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Adenosine-signalling.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Fredholm, Bertil B., Giulia Arslan, Bj�rn Kull, Ewa Kontny, and Per Svenningsson. "Adenosine (P1) receptor signalling." Drug Development Research 39, no. 3-4 (1996): 262–68. http://dx.doi.org/10.1002/(sici)1098-2299(199611/12)39:3/4<262::aid-ddr5>3.0.co;2-p.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

CARUSO, M., S. HOLGATE, and R. POLOSA. "Adenosine signalling in airways." Current Opinion in Pharmacology 6, no. 3 (2006): 251–56. http://dx.doi.org/10.1016/j.coph.2006.02.002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Silva, Luis, Mario Subiabre, Joaquín Araos, et al. "Insulin/adenosine axis linked signalling." Molecular Aspects of Medicine 55 (June 2017): 45–61. http://dx.doi.org/10.1016/j.mam.2016.11.002.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Burnstock, Geoffrey. "Purine and purinergic receptors." Brain and Neuroscience Advances 2 (January 2018): 239821281881749. http://dx.doi.org/10.1177/2398212818817494.

Full text

Abstract:

Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors have been cloned and characterised. P1 receptors are selective for adenosine, a breakdown product of adenosine 5′-triphosphate after degradation by ectonucleotidases. Four subtypes are recognised, A1, A2A, A2B and A3 receptors. P2 receptors are activated by purine and by pyrimidine nucleotides. P2X receptors are ligand-gated ion channel receptors (seven subunits (P2X1-7)), which form trimers as both homomultimers and hete

APA, Harvard, Vancouver, ISO, and other styles

5

Liang, Bruce T., Tomasz A. Swierkosz, Howard C. Herrmann, Stephen Kimmel, and Kenneth A. Jacobson. "Adenosine and Ischemic Preconditioning." Current Pharmaceutical Design 5, no. 12 (1999): 1029–41. http://dx.doi.org/10.2174/1381612805666230112212126.

Full text

Abstract:

Adenosine is released in large amounts during myocardial ischemia and is capable of exerting potent cardioprotective effects in the heart. Although these observations on adenosine have been known for a long time, how adenosine acts to achieve its anti-ischemic effect remains incompletely understood. However, recent advances on the chemistry and pharmacology of adenosine receptor ligands have provided important and novel information on the function of adenosine receptor subtypes in the cardiovascular system. The development of model systems for the cardiac actions of adenosine has yielded impor

APA, Harvard, Vancouver, ISO, and other styles

6

Vlajkovic, Srdjan M., and Peter R. Thorne. "Purinergic Signalling in the Cochlea." International Journal of Molecular Sciences 23, no. 23 (2022): 14874. http://dx.doi.org/10.3390/ijms232314874.

Full text

Abstract:

The mammalian cochlea is the sensory organ of hearing with a delicate, highly organised structure that supports unique operating mechanisms. ATP release from the secretory tissues of the cochlear lateral wall (stria vascularis) triggers numerous physiological responses by activating P2 receptors in sensory, supporting and neural tissues. Two families of P2 receptors, ATP-gated ion channels (P2X receptors) and G protein-coupled P2Y receptors, activate intracellular signalling pathways that regulate cochlear development, homeostasis, sensory transduction, auditory neurotransmission and response

APA, Harvard, Vancouver, ISO, and other styles

7

Razak, Azlina A., Lopa Leach, and Vera Ralevic. "Impaired vasocontractile responses to adenosine in chorionic vessels of human term placenta from pregnant women with pre-existing and gestational diabetes." Diabetes and Vascular Disease Research 15, no. 6 (2018): 528–40. http://dx.doi.org/10.1177/1479164118790904.

Full text

Abstract:

Background: There is clinical and experimental evidence for altered adenosine signalling in the fetoplacental circulation in pregnancies complicated by diabetes, leading to adenosine accumulation in the placenta. However, the consequence for fetoplacental vasocontractility is unclear. This study examined contractility to adenosine of chorionic vessels from type 1 diabetes mellitus, gestational diabetes mellitus and normal pregnancies. Methods: Chorionic arteries and veins were isolated from human placenta from normal, gestational diabetes mellitus and type 1 diabetes mellitus pregnancies. Isom

APA, Harvard, Vancouver, ISO, and other styles

8

DARCY, P. K., and P. R. FISHER. "Pharmacological evidence for a role for cyclic AMP signalling in Dictyostelium discoideum slug behaviour." Journal of Cell Science 96, no. 4 (1990): 661–67. http://dx.doi.org/10.1242/jcs.96.4.661.

Full text

Abstract:

Phototaxis and thermotaxis by Dictyostelium discoideum slugs on water agar were impaired by the presence in the agar of adenosine, which is a cyclic AMP receptor antagonist in aggregating amoebae. Caffeine, and presumably its analogue theophylline, inhibit cyclic AMP signalling in aggregating amoebae of D. discoideum. Both compounds perturbed slug behaviour in a similar manner to adenosine, as did both ammonium and sulphate ions. (NH4)3SO4 is known to perturb cyclic AMP binding to its receptor, and ammonia is an inhibitor of cyclic AMP signalling in aggregating amoebae. The receptor agonist, c

APA, Harvard, Vancouver, ISO, and other styles

9

Przybyła, Tomasz, Monika Sakowicz-Burkiewicz, and Tadeusz Pawełczyk. "Purinergic signalling in B cells." Acta Biochimica Polonica 65, no. 1 (2018): 1–7. http://dx.doi.org/10.18388/abp.2017_1588.

Full text

Abstract:

Adenosine and adenosine triphosphate are involved in purinergic signalling which plays important role in control of immune system. Much data have been obtained regarding impact of purinergic signalling on dendritic cells, macrophages, monocytes and T lymphocytes, however less attention has been paid to purinergic regulation of B cells. This review summarizes present knowledge about ATP- and Ado-dependant signalling in B lymphocytes. Human B cells have been shown to express A2A-R and A3-R and each subtype of P2 receptors. Surface of B cells exhibits two antagonistic ectoenzymatic pathways, on

APA, Harvard, Vancouver, ISO, and other styles

10

Gracia, Eduard, Kamil Pérez-Capote, Estefanía Moreno, et al. "A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase." Biochemical Journal 435, no. 3 (2011): 701–9. http://dx.doi.org/10.1042/bj20101749.

Full text

Abstract:

A2ARs (adenosine A2A receptors) are highly enriched in the striatum, which is the main motor control CNS (central nervous system) area. BRET (bioluminescence resonance energy transfer) assays showed that A2AR homomers may act as cell-surface ADA (adenosine deaminase; EC 3.5.4.4)-binding proteins. ADA binding affected the quaternary structure of A2ARs present on the cell surface. ADA binding to adenosine A2ARs increased both agonist and antagonist affinity on ligand binding to striatal membranes where these proteins are co-expressed. ADA also increased receptor-mediated ERK1/2 (extracellular-si

APA, Harvard, Vancouver, ISO, and other styles

11

Ciruela, Francisco, Carles Saura, Enric I. Canela, Josefa Mallol, Carmen Lluis, and Rafael Franco. "Adenosine deaminase affects ligand-induced signalling by interacting with cell surface adenosine receptors." FEBS Letters 380, no. 3 (1996): 219–23. http://dx.doi.org/10.1016/0014-5793(96)00023-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Aslam, Muhammad, Dursun Gündüz, Christian Troidl, Jacqueline Heger, Christian W. Hamm, and Rainer Schulz. "Purinergic Regulation of Endothelial Barrier Function." International Journal of Molecular Sciences 22, no. 3 (2021): 1207. http://dx.doi.org/10.3390/ijms22031207.

Full text

Abstract:

Increased vascular permeability is a hallmark of several cardiovascular anomalies, including ischaemia/reperfusion injury and inflammation. During both ischaemia/reperfusion and inflammation, massive amounts of various nucleotides, particularly adenosine 5′-triphosphate (ATP) and adenosine, are released that can induce a plethora of signalling pathways via activation of several purinergic receptors and may affect endothelial barrier properties. The nature of the effects on endothelial barrier function may depend on the prevalence and type of purinergic receptors activated in a particular tissu

APA, Harvard, Vancouver, ISO, and other styles

13

Spanoudakis, Chelsea, Rebecca Chapman, Simon Paine, Richard Grundy, Hester Franks, and Timothy Ritzmann. "EPEN-05. Adenosine receptor expression in paediatric ependymoma." Neuro-Oncology 24, Supplement_1 (2022): i39. http://dx.doi.org/10.1093/neuonc/noac079.142.

Full text

Abstract:

Abstract PURPOSE: Paediatric ependymoma is associated with dismal outcomes. Whilst understanding of its underlying biology has advanced, there has been little progress in treatment and clinical outcomes. Acting through four G protein-coupled receptors (encoded by ADORA1, ADORA2A, ADORA2B and ADORA3), adenosine is a signalling molecule often present at high levels in tumours. Adenosine signalling can aid tumour proliferation and invasiveness via mechanisms including suppression of tumour-infiltrating immune cells. Adenosine receptors therefore represent a potential therapeutic target in paediat

APA, Harvard, Vancouver, ISO, and other styles

14

Antonioli, Luca, Corrado Blandizzi, Balázs Csóka, Pál Pacher, and György Haskó. "Adenosine signalling in diabetes mellitus—pathophysiology and therapeutic considerations." Nature Reviews Endocrinology 11, no. 4 (2015): 228–41. http://dx.doi.org/10.1038/nrendo.2015.10.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Schulte, Gunnar, and Bertil B. Fredholm. "Signalling from adenosine receptors to mitogen-activated protein kinases." Cellular Signalling 15, no. 9 (2003): 813–27. http://dx.doi.org/10.1016/s0898-6568(03)00058-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

REES, D. Aled, Maurice F. SCANLON, and Jack HAM. "Novel insights into how purines regulate pituitary cell function." Clinical Science 104, no. 5 (2003): 467–81. http://dx.doi.org/10.1042/cs20030053.

Full text

Abstract:

Purine nucleosides and nucleotides are widely distributed substances that exhibit a diverse range of effects in a number of tissues, acting as important extracellular signalling molecules in addition to their more established roles in cellular metabolism. They mediate their effects via activation of distinct cell surface receptors, termed adenosine (or P1) and P2 purinergic receptors. Although roles for adenosine and adenine nucleotides have been described previously in the pituitary gland, the distribution of the receptor subtypes and the effects of their activation on pituitary function are

APA, Harvard, Vancouver, ISO, and other styles

17

Clark, Joanne C., Deirdre M. Kavanagh, Stephanie Watson, et al. "Adenosine and Forskolin Inhibit Platelet Aggregation by Collagen but not the Proximal Signalling Events." Thrombosis and Haemostasis 119, no. 07 (2019): 1124–37. http://dx.doi.org/10.1055/s-0039-1688788.

Full text

Abstract:

Background The G protein-coupled receptor, adenosine A2A, signals through the stimulatory G protein, Gs, in platelets leading to activation of adenylyl cyclase and elevation of cyclic adenosine monophosphate (cAMP) and inhibition of platelet activation. Objective This article investigates the effect of A2A receptor activation on signalling by the collagen receptor glycoprotein (GP) VI in platelets. Methods Washed human platelets were stimulated by collagen or the GPVI-specific agonist collagen-related peptide (CRP) in the presence of the adenosine receptor agonist, 5′-N-ethylcarboxamidoadenosi

APA, Harvard, Vancouver, ISO, and other styles

18

Liu, Yi, Sonia Rebollo-Ramirez, and Gerald Larrouy-Maumus. "Metabolomics reveals that the cAMP receptor protein regulates nitrogen and peptidoglycan synthesis in Mycobacterium tuberculosis." RSC Advances 10, no. 44 (2020): 26212–19. http://dx.doi.org/10.1039/d0ra05153e.

Full text

Abstract:

Mycobacterium tuberculosis requires extensive sensing and response to environment for its successful survival and pathogenesis, and signalling by cyclic adenosine 3′,5′-monophosphate (cAMP) is an important mechanism.

APA, Harvard, Vancouver, ISO, and other styles

19

Rees, DA, MF Scanlon, and J. Ham. "Adenosine signalling pathways in the pituitary gland: one ligand, multiple receptors." Journal of Endocrinology 177, no. 3 (2003): 357–64. http://dx.doi.org/10.1677/joe.0.1770357.

Full text

Abstract:

Adenosine receptors are widely distributed in most species and mediate a diverse range of physiological and pathological effects. Although adenosine receptors have been identified in the pituitary gland, the distribution of the individual subtypes (A(1), A(2A), A(2B), A(3)) has not been well defined. Furthermore, the effects of adenosine on pituitary trophic activity and function are not well established despite good evidence for growth- and immune-modulating properties of the nucleoside elsewhere. Recent advances have provided a more detailed description of adenosine receptor distribution and

APA, Harvard, Vancouver, ISO, and other styles

20

Schulte, Gunnar, and Bertil B. Fredholm. "Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists." Cellular Signalling 14, no. 2 (2002): 109–13. http://dx.doi.org/10.1016/s0898-6568(01)00228-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Andersson, Olov. "Role of adenosine signalling and metabolism in β-cell regeneration". Experimental Cell Research 321, № 1 (2014): 3–10. http://dx.doi.org/10.1016/j.yexcr.2013.11.019.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Ralevic, Vera. "Hypoxic vasodilatation: is an adenosine–prostaglandins–NO signalling cascade involved?" Journal of Physiology 544, no. 1 (2002): 2. http://dx.doi.org/10.1113/jphysiol.2002.028902.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Bernascone, Silvia, Jessica Erriquez, Mario Ferraro, Armando A. Genazzani, and Carla Distasi. "Novel adenosine and cAMP signalling pathways in migrating glial cells." Cell Calcium 48, no. 1 (2010): 83–90. http://dx.doi.org/10.1016/j.ceca.2010.07.004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Matthews, Gareth DK, and Andrew A. Grace. "Unmasking Adenosine: The Purinergic Signalling Molecule Critical to Arrhythmia Pathophysiology and Management." Arrhythmia & Electrophysiology Review 8, no. 4 (2020): 240–48. http://dx.doi.org/10.15420/aer.2019.05.

Full text

Abstract:

Adenosine was identified in 1929 and immediately recognised as having a potential role in therapy for arrhythmia because of its negative chronotropic and dromotropic effects. Adenosine entered mainstream use in the 1980s as a highly effective agent for the termination of supraventricular tachycardia (SVT) involving the atrioventricular node, as well as for its ability to unmask the underlying rhythm in other SVTs. Adenosine has subsequently been found to have applications in interventional electrophysiology. While considered a safe agent because of its short half-life, adenosine may provoke ar

APA, Harvard, Vancouver, ISO, and other styles

25

Winder, Michael, Gunnar Tobin, Daša Zupančič, and Rok Romih. "Signalling Molecules in the Urothelium." BioMed Research International 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/297295.

Full text

Abstract:

The urothelium was long considered to be a silent barrier protecting the body from the toxic effects of urine. However, today a number of dynamic abilities of the urothelium are well recognized, including its ability to act as a sensor of the intravesical environment. During recent years several pathways of these urothelial abilities have been proposed and a major part of these pathways includes release of signalling molecules. It is now evident that the urothelium represents only one part of the sensory web. Urinary bladder signalling is finely tuned machinery of signalling molecules, acting

APA, Harvard, Vancouver, ISO, and other styles

26

Durham, Gillian A., and Timothy M. Palmer. "Is there a role for prostanoid-mediated inhibition of IL-6 trans-signalling in the management of pulmonary arterial hypertension?" Biochemical Society Transactions 47, no. 4 (2019): 1143–56. http://dx.doi.org/10.1042/bst20190046.

Full text

Abstract:

Abstract Inflammation has been highlighted as a key factor in pulmonary arterial hypertension (PAH) development, particularly interleukin-6 (IL-6). IL-6 activates JAK-STAT signalling to induce transcription of pro-inflammatory and pro-angiogenic genes, enabling PAH progression, as well as the transcription of suppressor of cytokine signalling 3 (SOCS3) which limits IL-6 signalling. Current PAH therapies include prostanoid drugs which induce vasodilation via stimulating intracellular 3′,5′-cyclic adenosine monophosphate (cAMP) levels. cAMP can also inhibit IL-6-mediated endothelial dysfunction

APA, Harvard, Vancouver, ISO, and other styles

27

Frezza, Christian. "Mitochondrial metabolites: undercover signalling molecules." Interface Focus 7, no. 2 (2017): 20160100. http://dx.doi.org/10.1098/rsfs.2016.0100.

Full text

Abstract:

Mitochondria are one of most characterized metabolic hubs of the cell. Here, crucial biochemical reactions occur and most of the cellular adenosine triphosphate (ATP) is produced. In addition, mitochondria act as signalling platforms and communicate with the rest of the cell by modulating calcium fluxes, by producing free radicals, and by releasing bioactive proteins. It is emerging that mitochondrial metabolites can also act as second messengers and can elicit profound (epi)genetic changes. This review describes the many signalling functions of mitochondrial metabolites under normal and stres

APA, Harvard, Vancouver, ISO, and other styles

28

Cabiati, Manuela, Raffaele Caruso, Alessandro Verde, Laura Sabatino, Maria-Aurora Morales, and Silvia Del Ry. "Transcriptomic Profiling of the Four Adenosine Receptors in Human Leukocytes of Heart Failure Patients." BioMed Research International 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/569438.

Full text

Abstract:

In this study the transcriptomic profiling of adenosine receptors (ARs) in human leukocytes of heart failure (HF) patients as a function of clinical severity, assessing the possible changes with respect to healthy subjects (C), was evaluated. Total RNA was extracted from leukocytes ofC(n=8) and of HF patients (NYHA I-IIn=9; NYHA III-IVn=14) with a PAXgene Blood RNA Kit. An increase as a function of clinical severity was observed in each AR (A1R:C=0.02±0.009, NYHAI-II=0.21±0.09, NYHAIII-IV=3.6±1.3,P=0.03 Cversus NYHA III-IV,P=0.02NYHA I-II versus NYHA III-IV; A2aR:C=0.2±0.05, NYHAI-II=0.19±0.04

APA, Harvard, Vancouver, ISO, and other styles

29

Htet, Myo, Jane E. Nally, Patricia E. Martin, and Yvonne Dempsie. "New Insights into Pulmonary Hypertension: A Role for Connexin-Mediated Signalling." International Journal of Molecular Sciences 23, no. 1 (2021): 379. http://dx.doi.org/10.3390/ijms23010379.

Full text

Abstract:

Pulmonary hypertension is a serious clinical condition characterised by increased pulmonary arterial pressure. This can lead to right ventricular failure which can be fatal. Connexins are gap junction-forming membrane proteins which serve to exchange small molecules of less than 1 kD between cells. Connexins can also form hemi-channels connecting the intracellular and extracellular environments. Hemi-channels can mediate adenosine triphosphate release and are involved in autocrine and paracrine signalling. Recently, our group and others have identified evidence that connexin-mediated signallin

APA, Harvard, Vancouver, ISO, and other styles

30

Chernogorova, Petya, and Robert Zeiser. "Ectonucleotidases in Solid Organ and Allogeneic Hematopoietic Cell Transplantation." Journal of Biomedicine and Biotechnology 2012 (2012): 1–17. http://dx.doi.org/10.1155/2012/208204.

Full text

Abstract:

Extracellular nucleotides are ubiquitous signalling molecules which modulate distinct physiological and pathological processes. Nucleotide concentrations in the extracellular space are strictly regulated by cell surface enzymes, called ectonucleotidases, which hydrolyze nucleotides to the respective nucleosides. Recent studies suggest that ectonucleotidases play a significant role in inflammation by adjusting the balance between ATP, a widely distributed proinflammatory danger signal, and the anti-inflammatory mediator adenosine. There is increasing evidence for a central role of adenosine in

APA, Harvard, Vancouver, ISO, and other styles

31

Czajkowski, Rafał, and Jolanta Barańska. "Cross-talk between the ATP and ADP nucleotide receptor signalling pathways in glioma C6 cells." Acta Biochimica Polonica 49, no. 4 (2002): 877–89. http://dx.doi.org/10.18388/abp.2002_3747.

Full text

Abstract:

In this review we summarize the present status of our knowledge on the enzymes involved in the extracellular metabolism of nucleotides and the receptors involved in nucleotide signalling. We focus on the mechanism of the ATP and ADP signalling pathways in glioma C6, representative of the type of nonexcitable cells. In these cells, ATP acts on the P2Y(2) receptor coupled to phospholipase C, whereas ADP on two distinct P2Y receptors: P2Y(1) and P2Y(12). The former is linked to phospholipase C and the latter is negatively coupled to adenylyl cyclase. The possible cross-talk between the ATP-, ADP-

APA, Harvard, Vancouver, ISO, and other styles

32

Luchowska-Stańska, Urszula, David Morgan, Stephen J. Yarwood, and Graeme Barker. "Selective small-molecule EPAC activators." Biochemical Society Transactions 47, no. 5 (2019): 1415–27. http://dx.doi.org/10.1042/bst20190254.

Full text

Abstract:

Abstract The cellular signalling enzymes, EPAC1 and EPAC2, have emerged as key intracellular sensors of the secondary messenger cyclic 3′,5′-adenosine monophosphate (cyclic adenosine monophosphate) alongside protein kinase A. Interest has been galvanised in recent years thanks to the emergence of these species as potential targets for new cardiovascular disease therapies, including vascular inflammation and insulin resistance in vascular endothelial cells. We herein summarise the current state-of-the-art in small-molecule EPAC activity modulators, including cyclic nucleotides, sulphonylureas,

APA, Harvard, Vancouver, ISO, and other styles

33

Bhujbal, Swapnil P., and Jung-Mi Hah. "Generation of Non-Nucleotide CD73 Inhibitors Using a Molecular Docking and 3D-QSAR Approach." International Journal of Molecular Sciences 22, no. 23 (2021): 12745. http://dx.doi.org/10.3390/ijms222312745.

Full text

Abstract:

Radiotherapy and chemotherapy are conventional cancer treatments. Around 60% of all patients who are diagnosed with cancer receive radio- or chemotherapy in combination with surgery during their disease. Only a few patients respond to the blockage of immune checkpoints alone, or in combination therapy, because their tumours might not be immunogenic. Under these circumstances, an increasing level of extracellular adenosine via the activation of ecto-5’-nucleotidase (CD73) and consequent adenosine receptor signalling is a typical mechanism that tumours use to evade immune surveillance. CD73 is r

APA, Harvard, Vancouver, ISO, and other styles

34

Koshiba, Masahiro, Hidekazu Kosaka, Takashi Nakazawa, et al. "2-Chloroadenosine but not adenosine induces apoptosis in rheumatoid fibroblasts independently of cell surface adenosine receptor signalling." British Journal of Pharmacology 135, no. 6 (2002): 1477–86. http://dx.doi.org/10.1038/sj.bjp.0704612.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Tsiampali, Julia, Silke Neumann, Beatriz Giesen, et al. "Enzymatic Activity of CD73 Modulates Invasion of Gliomas via Epithelial–Mesenchymal Transition-Like Reprogramming." Pharmaceuticals 13, no. 11 (2020): 378. http://dx.doi.org/10.3390/ph13110378.

Full text

Abstract:

Glioblastoma (GBM) is the most aggressive malignant primary brain tumour in adulthood. Despite strong research efforts current treatment options have a limited impact on glioma stem-like cells (GSCs) which contribute to GBM formation, progression and chemoresistance. Invasive growth of GSCs is in part associated with epithelial–mesenchymal-like transition (EMT), a mechanism associated with CD73 in several cancers. Here, we show that CD73 regulates the EMT activator SNAIL1 and further investigate the role of enzymatic and non-enzymatic CD73 activity in GBM progression. Reduction of CD73 protein

APA, Harvard, Vancouver, ISO, and other styles

36

DORIS, ROSEMARIE, ELAINE KILGOUR, MILES D. HOUSLAY, GORDON E. THOMPSON, and RICHARD G. VERNON. "Modulation of adenosine signalling in sheep adipose tissue by growth hormone." Biochemical Society Transactions 23, no. 1 (1995): 16S. http://dx.doi.org/10.1042/bst023016s.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Meng, Fan, Zhige Guo, Yaling Hu, et al. "CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling." Brain 142, no. 3 (2019): 700–718. http://dx.doi.org/10.1093/brain/awy351.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Angioni, Roberta, Cristina Liboni, Stephanie Herkenne, et al. "CD73 + extracellular vesicles inhibit angiogenesis through adenosine A 2B receptor signalling." Journal of Extracellular Vesicles 9, no. 1 (2020): 1757900. http://dx.doi.org/10.1080/20013078.2020.1757900.

Full text

APA, Harvard, Vancouver, ISO, and other styles

39

Fulle, S. "Purinergic signalling during myogenesis: a role for adenosine and its receptors." Acta Physiologica 214, no. 4 (2015): 436–39. http://dx.doi.org/10.1111/apha.12542.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Kaplan, G. B., K. A. Leite-Morris, M. T. Sears, E. G. McClelland, and R. K. Sethi. "Regulation of adenosine- and G protein-mediated signalling in opiate dependence." Biological Psychiatry 39, no. 7 (1996): 505. http://dx.doi.org/10.1016/0006-3223(96)83969-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Williams-Pritchard, Grant, Jason Peart, Peter Johnson та John Headrick. "Signalling Cross-Talk Between Cardiomyocyte δ-Opioid and Adenosine A1 Receptors". Heart, Lung and Circulation 17 (2008): S229. http://dx.doi.org/10.1016/j.hlc.2008.05.573.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Spormann, Luise, Christiane Rennert, Erik Kolbe, et al. "Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver." Cells 9, no. 8 (2020): 1817. http://dx.doi.org/10.3390/cells9081817.

Full text

Abstract:

In the liver, energy homeostasis is mainly regulated by mechanistic target of rapamycin (mTOR) signalling, which influences relevant metabolic pathways, including lipid metabolism. However, the Hedgehog (Hh) pathway is one of the newly identified drivers of hepatic lipid metabolism. Although the link between mTOR and Hh signalling was previously demonstrated in cancer development and progression, knowledge of their molecular crosstalk in healthy liver is lacking. To close this information gap, we used a transgenic mouse model, which allows hepatocyte-specific deletion of the Hh pathway, and in

APA, Harvard, Vancouver, ISO, and other styles

43

Menéndez Méndez, Aida, Jonathon Smith, and Tobias Engel. "Neonatal Seizures and Purinergic Signalling." International Journal of Molecular Sciences 21, no. 21 (2020): 7832. http://dx.doi.org/10.3390/ijms21217832.

Full text

Abstract:

Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes. Current treatment can control early life seizures; however, a high level of pharmacoresistance remains among infants, with increasing evidence suggesting current anti-seizure medication potentiating brain damage. This emphasises the need to develop safer therapeutic strategies with a different mechanism of action. The purinergic system, characterised by the use of adenosine triphosphate and its metabolites as signalling molecules, consists of the

APA, Harvard, Vancouver, ISO, and other styles

44

Vieira, Cátia, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, et al. "Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis." Mediators of Inflammation 2014 (2014): 1–19. http://dx.doi.org/10.1155/2014/254640.

Full text

Abstract:

Purinergic signalling is remarkably plastic during gastrointestinal inflammation. Thus, selective drugs targeting the “purinome” may be helpful for inflammatory gastrointestinal diseases. The myenteric neuromuscular transmission of healthy individuals is fine-tuned and controlled by adenosine acting onA2Aexcitatory receptors. Here, we investigated the neuromodulatory role of adenosine in TNBS-inflamed longitudinal muscle-myenteric plexus of the rat ileum. Seven-day postinflammation ileitis lacks adenosine neuromodulation, which may contribute to acceleration of gastrointestinal transit. The lo

APA, Harvard, Vancouver, ISO, and other styles

45

Baker, David A., Laura G. Drought, Christian Flueck, et al. "Cyclic nucleotide signalling in malaria parasites." Open Biology 7, no. 12 (2017): 170213. http://dx.doi.org/10.1098/rsob.170213.

Full text

Abstract:

The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types. They usually mediate an extracellular stimulus to drive a change in cell function through activation of their respective cyclic nucleotide-dependent protein kinases, PKA and PKG. The enzymatic components of the malaria parasite cyclic nucleotide signalling pathways have been identified, and the genetic and biochemical studies of these enzymes carried out to date are reviewed herein. What has become very clear is that

APA, Harvard, Vancouver, ISO, and other styles

46

Monterisi, Stefania, and Manuela Zaccolo. "Components of the mitochondrial cAMP signalosome." Biochemical Society Transactions 45, no. 1 (2017): 269–74. http://dx.doi.org/10.1042/bst20160394.

Full text

Abstract:

3′-5′-Cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signalling is activated by different extracellular stimuli and mediates many diverse processes within the same cell. It is now well established that in order to translate into the appropriate cellular function multiple extracellular inputs, which may act simultaneously on the same cell, the cAMP/PKA signalling pathway is compartmentalised. Multimolecular complexes are organised at specific subcellular sites to generate spatially confined signalosomes, which include effectors, modulators and targets of the pathway. In recent years

APA, Harvard, Vancouver, ISO, and other styles

47

dos Anjos, Fernanda, Júlia Leão Batista Simões, Charles Elias Assmann, Fabiano Barbosa Carvalho, and Margarete Dulce Bagatini. "Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS-CoV-2." Journal of Immunology Research 2020 (December 1, 2020): 1–14. http://dx.doi.org/10.1155/2020/8632048.

Full text

Abstract:

Novel coronavirus disease 2019 (COVID-19) causes pulmonary and cardiovascular disorders and has become a worldwide emergency. Myocardial injury can be caused by direct or indirect damage, particularly mediated by a cytokine storm, a disordered immune response that can cause myocarditis, abnormal coagulation, arrhythmia, acute coronary syndrome, and myocardial infarction. The present review focuses on the mechanisms of this viral infection, cardiac biomarkers, consequences, and the possible therapeutic role of purinergic and adenosinergic signalling systems. In particular, we focus on the inter

APA, Harvard, Vancouver, ISO, and other styles

48

Villalobos-Labra, Roberto, Luis Silva, Mario Subiabre, et al. "Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy." Journal of Diabetes Research 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/5947859.

Full text

Abstract:

Insulin resistance is characteristic of pregnancies where the mother shows metabolic alterations, such as preeclampsia (PE) and gestational diabetes mellitus (GDM), or abnormal maternal conditions such as pregestational maternal obesity (PGMO). Insulin signalling includes activation of insulin receptor substrates 1 and 2 (IRS1/2) as well as Src homology 2 domain-containing transforming protein 1, leading to activation of 44 and 42 kDa mitogen-activated protein kinases and protein kinase B/Akt (Akt) signalling cascades in the human foetoplacental vasculature. PE, GDM, and PGMO are abnormal cond

APA, Harvard, Vancouver, ISO, and other styles

49

Massimo Caruso, Giovanni Tringali, and Riccardo Polosa. "Evidence For A Functional Contribution of Adenosine Signalling in Inflammatory Airway Diseases." Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 7, no. 4 (2007): 286–97. http://dx.doi.org/10.2174/187152207781369896.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Atterbury, Alison, and Mark J. Wall. "Adenosine signalling at immature parallel fibre-Purkinje cell synapses in rat cerebellum." Journal of Physiology 587, no. 18 (2009): 4497–508. http://dx.doi.org/10.1113/jphysiol.2009.176420.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!