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Journal articles on the topic 'Adenoviral; Nervous system; Central'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

Parks, Robin J., and Jonathan L. Bramson. "Adenoviral vectors: prospects for gene delivery to the central nervous system." Gene Therapy 6, no. 8 (1999): 1349–50. http://dx.doi.org/10.1038/sj.gt.3301013.

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2

Davidson, Beverly L., Edward D. Allen, Karen F. Kozarsky, James M. Wilson, and Blake J. Roessler. "A model system for in vivo gene transfer into the central nervous system using an adenoviral vector." Nature Genetics 3, no. 3 (1993): 219–23. http://dx.doi.org/10.1038/ng0393-219.

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3

Schwartz, Kevin L., Susan E. Richardson, Daune MacGregor, Sanjay Mahant, Kamini Raghuram, and Ari Bitnun. "Adenovirus-Associated Central Nervous System Disease in Children." Journal of Pediatrics 205 (February 2019): 130–37. http://dx.doi.org/10.1016/j.jpeds.2018.09.036.

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4

Zou, Linglong, Heshan Zhou, Lucio Pastore, and Keyi Yang. "Prolonged Transgene Expression Mediated by a Helper-Dependent Adenoviral Vector (hdAd) in the Central Nervous System." Molecular Therapy 2, no. 2 (2000): 105–13. http://dx.doi.org/10.1006/mthe.2000.0104.

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5

Vincent, Arnaud J. P. E., Maria del C. Esandi, Cees J. J. Avezaat, et al. "Preclinical Testing of Recombinant Adenoviral Herpes Simplex Virus-Thymidine Kinase Gene Therapy for Central Nervous System Malignancies." Neurosurgery 41, no. 2 (1997): 442–52. http://dx.doi.org/10.1097/00006123-199708000-00023.

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6

Betz, A. Lorris, Guo-Yuan Yang, and Beverly L. Davidson. "Attenuation of Stroke Size in Rats Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist in Brain." Journal of Cerebral Blood Flow & Metabolism 15, no. 4 (1995): 547–51. http://dx.doi.org/10.1038/jcbfm.1995.68.

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Adenoviruses have been proposed as potential vectors for gene therapy in the central nervous system, but there are no reports of their use in the treatment of a brain disease. Because central administration of interleukin-1 receptor antagonist protein (IL-1ra) reduces ischemic brain damage, we determined whether a recombinant adenovirus vector carrying the human IL-1ra cDNA (Ad.RSV IL-1ra) could be used to ameliorate brain injury in permanent focal ischemia. Groups of six rats received intraventricular injections of Ad.RSV IL-1ra or a control adenovirus containing the Escherichia coli β-galact

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7

Shen, J.-S., X.-L. Meng, T. Ohashi, and Y. Eto. "Adenovirus-mediated prenatal gene transfer to murine central nervous system." Gene Therapy 9, no. 12 (2002): 819–23. http://dx.doi.org/10.1038/sj.gt.3301700.

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8

Huang, Yhu-Chering, Sun-Lin Huang, Shih-Perng Chen, et al. "Adenovirus infection associated with central nervous system dysfunction in children." Journal of Clinical Virology 57, no. 4 (2013): 300–304. http://dx.doi.org/10.1016/j.jcv.2013.03.017.

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9

Viola, John J., Zvi Ram, Stuart Walbridge, et al. "Adenovirally mediated gene transfer into experimental solid brain tumors and leptomeningeal cancer cells." Journal of Neurosurgery 82, no. 1 (1995): 70–76. http://dx.doi.org/10.3171/jns.1995.82.1.0070.

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✓ Among the appealing features of adenoviruses as vectors for transfer of genes into the central nervous system (CNS) are that they are not neurotoxic, they can accommodate the insertion of several large genes, they are not associated with the hazards of insertional mutagenesis, and they can be concentrated to a high-titer preparation. The authors evaluated the feasibility of using adenovirally mediated gene transfer into cultured human glioma cells and in rat models of solid brain tumors and meningeal cancer. Replication-deficient adenoviral vector particles carrying a nuclear-localizing lacZ

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10

Boulis, Nicholas M., Vikas Bhatia, Theodore I. Brindle та ін. "Adenoviral nerve growth factor and β-galactosidase transfer to spinal cord: a behavioral and histological analysis". Journal of Neurosurgery: Spine 90, № 1 (1999): 99–108. http://dx.doi.org/10.3171/spi.1999.90.1.0099.

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Object. The present study characterizes the time course and loci of gene expression induced by the administration of adenoviral vectors into spinal cord. Although a marked inflammatory response to these vectors occurred, no effect on spinal cord function was seen in the 1st postoperative week. The expression of transgenic genes delivered by viral vectors is being exploited throughout the nervous system. The present study utilized adenoviral vectors containing the Rous sarcoma virus (RSV) promoter and a nuclear localization signal to achieve transgenic expression in mammalian spinal cord. Metho

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11

Lewis, Travis, Joel Glasgow, Ashley Harms, David Standaert, and David Curiel. "Fiber-Modified Adenovirus for Central Nervous System Parkinson’s Disease Gene Therapy." Viruses 6, no. 8 (2014): 3293–310. http://dx.doi.org/10.3390/v6083293.

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12

Chen, X., X. Zhao, Y. Hu, et al. "The spread of adenoviral vectors to central nervous system through pathway of cochlea in mimetic aging and young rats." Gene Therapy 22, no. 11 (2015): 866–75. http://dx.doi.org/10.1038/gt.2015.63.

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13

Plumb, Troy J., Assumpció Bosch, Blake J. Roessler, Donna S. Shewach, and Beverly L. Davidson. "Hypoxanthine-guanine phosphoribosyltransferase (HPRT) expression in the central nervous system of HPRT-deficient mice following adenoviral-mediated gene transfer." Neuroscience Letters 214, no. 2-3 (1996): 159–62. http://dx.doi.org/10.1016/0304-3940(96)12932-3.

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14

Lemiale, Franck, Wing-pui Kong, Levent M. Akyürek, et al. "Enhanced Mucosal Immunoglobulin A Response of Intranasal Adenoviral Vector Human Immunodeficiency Virus Vaccine and Localization in the Central Nervous System." Journal of Virology 77, no. 18 (2003): 10078–87. http://dx.doi.org/10.1128/jvi.77.18.10078-10087.2003.

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ABSTRACT Replication-defective adenovirus (ADV) vectors represent a promising potential platform for the development of a vaccine for AIDS. Although this vector is typically administered intramuscularly, it would be desirable to induce mucosal immunity by delivery through alternative routes. In this study, the immune response and biodistribution of ADV vectors delivered by different routes were evaluated. ADV vectors expressing human immunodeficiency virus type 1 (HIV-1) Gag, Pol, and Env were delivered intramuscularly or intranasally into mice. Intranasal immunization induced greater HIV-spec

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15

Frange, Pierre, Régis Peffault de Latour, Cécile Arnaud, et al. "Adenoviral Infection Presenting as an Isolated Central Nervous System Disease without Detectable Viremia in Two Children after Stem Cell Transplantation." Journal of Clinical Microbiology 49, no. 6 (2011): 2361–64. http://dx.doi.org/10.1128/jcm.00080-11.

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16

Horellou, Philippe, Olivier Sabaté, Marie-Hélène Buc-Caron, and Jacques Mallet. "Adenovirus-Mediated Gene Transfer to the Central Nervous System for Parkinson's Disease." Experimental Neurology 144, no. 1 (1997): 131–38. http://dx.doi.org/10.1006/exnr.1996.6399.

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17

Blits, Bas, Gerard J. Boer, and Joost Verhaagen. "Pharmacological, Cell, and Gene Therapy Strategies to Promote Spinal Cord Regeneration." Cell Transplantation 11, no. 6 (2002): 593–613. http://dx.doi.org/10.3727/000000002783985521.

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In this review, recent studies using pharmacological treatment, cell transplantation, and gene therapy to promote regeneration of the injured spinal cord in animal models will be summarized. Pharmacological and cell transplantation treatments generally revealed some degree of effect on the regeneration of the injured ascending and descending tracts, but further improvements to achieve a more significant functional recovery are necessary. The use of gene therapy to promote repair of the injured nervous system is a relatively new concept. It is based on the development of methods for delivering

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18

Chillon, Miguel, Assumpció Bosch, Joseph Zabner, et al. "Group D Adenoviruses Infect Primary Central Nervous System Cells More Efficiently than Those from Group C." Journal of Virology 73, no. 3 (1999): 2537–40. http://dx.doi.org/10.1128/jvi.73.3.2537-2540.1999.

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ABSTRACT Group C adenovirus-mediated gene transfer to central nervous system cells is inefficient. We found that wild-type group D viruses, or recombinant adenovirus type 2 (Ad2) (group C) modified to contain Ad17 (group D) fiber, were more efficient in infecting primary cultures of neurons. Together with studies on primary vascular endothelial cells and tissue culture cell lines, our results indicate that there is not a universally applicable adenovirus serotype for use as a gene transfer vector.

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19

Blits, Bas, Paul A. Dijkhuizen, Thomas P. Carlstedt, et al. "Adenoviral Vector-Mediated Expression of a Foreign Gene in Peripheral Nerve Tissue Bridges Implanted in the Injured Peripheral and Central Nervous System." Experimental Neurology 160, no. 1 (1999): 256–67. http://dx.doi.org/10.1006/exnr.1999.7204.

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20

Zheng, Hong, Keshore R. Bidasee, William G. Mayhan, and Kaushik P. Patel. "Lack of central nitric oxide triggers erectile dysfunction in diabetes." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 292, no. 3 (2007): R1158—R1164. http://dx.doi.org/10.1152/ajpregu.00429.2006.

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Erectile dysfunction is a serious and common complication of diabetes mellitus. The proposed mechanisms for erectile dysfunction in diabetes include central and autonomic neuropathy, endothelial dysfunction, and smooth muscle dysfunction. The paraventricular nucleus (PVN) of the hypothalamus is known to be involved in centrally mediated penile erection. This study was designed to examine the role of nitric oxide (NO) within the central nervous system component of the behavioral responses including erection in diabetic rats. N-methyl-d-aspartic acid (NMDA)-induced erection, yawning, and stretch

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21

Persson, Annette, Xiaolong Fan, Bengt Widegren, and Elisabet Englund. "Cell type- and region- dependent coxsackie adenovirus receptor expression in the central nervous system." Journal of Neuro-Oncology 78, no. 1 (2005): 1–6. http://dx.doi.org/10.1007/s11060-005-9055-3.

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22

Broder, Howard, Andrea Anderson, Sylvia K. Odesa, Thomas J. Kremen, and Linda M. Liau. "Recombinant adenovirus-transduced dendritic cell immunization in a murine model of central nervous system tumor." Neurosurgical Focus 9, no. 6 (2000): 1–8. http://dx.doi.org/10.3171/foc.2000.9.6.7.

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Object Dendritic cells (DCs) are potent antigen-presenting cells that have been shown to play a critical role in the initiation of host immune responses against tumor antigens. In this study, a recombinant adenovirus vector encoding the melanoma-associated antigen, MART-1, was used to transduce murine DCs, which were then tested for their ability to activate cytotoxic T lymphocytes (CTLs) and induce protective immunity against B16 melanoma tumor cells implanted intracranially. Methods Genetic modification of murine bone marrrow–derived DCs to express MART-1 was achieved through the use of an E

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23

Ghodsi, Abdi, Colleen Stein, Todd Derksen, Gongyu Yang, Richard D. Anderson та Beverly L. Davidson. "Extensiveβ-Glucuronidase Activity in Murine Central Nervous System after Adenovirus-Mediated Gene Transfer to Brain". Human Gene Therapy 9, № 16 (1998): 2331–40. http://dx.doi.org/10.1089/hum.1998.9.16-2331.

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24

Stein, Colleen S., Abdi Ghodsi, Todd Derksen, and Beverly L. Davidson. "Systemic and Central Nervous System Correction of Lysosomal Storage in Mucopolysaccharidosis Type VII Mice." Journal of Virology 73, no. 4 (1999): 3424–29. http://dx.doi.org/10.1128/jvi.73.4.3424-3429.1999.

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ABSTRACT Mucopolysaccharidosis (MPS) type VII patients lack functional β-glucuronidase, leading to systemic and central nervous system dysfunction. In this study we tested whether recombinant adenovirus that encodes β-glucuronidase (Adβgluc), delivered intravenously and into the brain parenchyma of MPS type VII mice, could provide long-term transgene expression and correction of lysosomal distension. We also tested whether systemic treatment with the immunosuppressive anti-CD40 ligand antibody, MR-1, affected transgene expression. We found substantial plasma β-glucuronidase activity for over 9

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25

Luu, Wing, James Bjork, Erin Salo, et al. "Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice." International Journal of Molecular Sciences 20, no. 9 (2019): 2251. http://dx.doi.org/10.3390/ijms20092251.

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The ATP-sensitive K+ channel (KATP) is involved in hypersensitivity during chronic pain and is presumed to be a downstream target of mu opioid receptors. Multiple subtypes of KATP channels exist in the peripheral and central nervous system and their activity may be inversely correlated to chronic pain phenotypes in rodents. In this study, we investigated the different KATP channel subunits that could be involved in neuropathic pain in mice. In chronic pain models utilizing spinal nerve ligation, SUR1 and Kir6.2 subunits were found to be significantly downregulated in dorsal root ganglia and th

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26

OH, Seunguk, Rick Odland, Scott R. Wilson, et al. "Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter." Journal of Neurosurgery 107, no. 3 (2007): 568–77. http://dx.doi.org/10.3171/jns-07/09/0568.

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Object A hollow fiber catheter was developed to improve the distribution of drugs administered via direct infusion into the central nervous system (CNS). It is a porous catheter that significantly increases the surface area of brain tissue into which a drug is infused. Methods Dye was infused into the mouse brain through convection-enhanced delivery (CED) using a 28-gauge needle compared with a 3-mm-long hollow fiber catheter. To determine whether a hollow fiber catheter could increase the distribution of gene therapy vectors, a recombinant adenovirus expressing the firefly luciferase reporter

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27

Okado, Haruo, Akiko Miwa, and Toshio Terashma. "2801 Plausible differential mechanism of adenovirus-mediated gene transfer into various regions of central nervous system." Neuroscience Research 25 (January 1996): S267. http://dx.doi.org/10.1016/0168-0102(96)89307-2.

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28

Kuo, Hui, Donald K. Ingram, Ronald G. Crystal, and Andrea Mastrangeli. "Retrograde transfer of replication deficient recombinant adenovirus vector in the central nervous system for tracing studies." Brain Research 705, no. 1-2 (1995): 31–38. http://dx.doi.org/10.1016/0006-8993(95)01065-3.

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29

Cowsill, C., T. D. Southgate, G. Morrissey, et al. "Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK." Gene Therapy 7, no. 8 (2000): 679–85. http://dx.doi.org/10.1038/sj.gt.3301147.

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30

Bajocchi, Gianluigi, Sanford H. Feldman, Ronald G. Crystal, and Andrea Mastrangeli. "Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors." Nature Genetics 3, no. 3 (1993): 229–34. http://dx.doi.org/10.1038/ng0393-229.

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31

Broder, Howard, Andrea Anderson, Thomas J. Kremen, Sylvia K. Odesa, and Linda M. Liau. "MART-1 adenovirus-transduced dendritic cell immunization in a murine model of metastatic central nervous system tumor." Journal of Neuro-oncology 64, no. 1-2 (2003): 21–30. http://dx.doi.org/10.1007/bf02700017.

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32

Neuwelt, Edward A., Michael A. Pagel, Alfred Geller, and Leslie L. Muldoon. "Gene replacement therapy in the central nervous system: Viral vector-mediated therapy of global neurodegenerative disease." Behavioral and Brain Sciences 18, no. 1 (1995): 1–9. http://dx.doi.org/10.1017/s0140525x00037237.

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AbstractThis target article describes the current state of global gene replacement in the brain using viral vectors and assesses possible solutions to some of the many problems inherent in gene therapy of the central nervous system (CNS). Gene replacement therapy in the CNS is a potential means of producing a stable expression of normal human proteins in deficient cells and thus curing certain genetically inherited enzyme deficiencies and metabolic diseases as well as cancers. The two major issues to be addressed in CNS gene replacement are the delivery of genetic material to the brain and the

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Oh, Seunguk, G. Elizabeth Pluhar, Elizabeth A. McNeil, et al. "Efficacy of nonviral gene transfer in the canine brain." Journal of Neurosurgery 107, no. 1 (2007): 136–44. http://dx.doi.org/10.3171/jns-07/07/0136.

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Object The purpose of this study was to evaluate the gene transfer capability and tolerability of plasmid DNA/poly-ethylenimine (PEI) complexes in comparison with adenovirus and naked plasmid DNA in the canine brain. Methods Plasmid or adenoviral vectors encoding firefly luciferase were injected directly into the cerebral parenchyma of five adult dogs at varying doses and volumes. Serial physical and neurological examinations, as well as blood and cerebrospinal fluid (CSF) analyses, were conducted before and after the surgery for 3 days. Three days after gene delivery, a luciferase activity as

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Trifilo, Matthew J., and Thomas E. Lane. "Adenovirus-Mediated Expression of CXCL10 in the Central Nervous System Results in T-Cell Recruitment and Limited Neuropathology." Journal of Neurovirology 9, no. 3 (2003): 315–24. http://dx.doi.org/10.1080/13550280390201029.

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35

Ariza, Lorena, Lydia Giménez-Llort, Aurélie Cubizolle, et al. "Central Nervous System Delivery of Helper-Dependent Canine Adenovirus Corrects Neuropathology and Behavior in Mucopolysaccharidosis Type VII Mice." Human Gene Therapy 25, no. 3 (2014): 199–211. http://dx.doi.org/10.1089/hum.2013.152.

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36

CHESKY, MARISA, ROSANA SCALCO, LUCIANE FAILACE, STEVEN READ, and LUIZ FERNANDO JOBIM. "Polymerase chain reaction for the laboratory diagnosis of aseptic meningitis and encephalitis." Arquivos de Neuro-Psiquiatria 58, no. 3B (2000): 836–42. http://dx.doi.org/10.1590/s0004-282x2000000500008.

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A protocol for testing cerebrospinal fluid specimens using a range of PCR assays for the diagnosis of central nervous system infection was developed and used to test prospectively 383 specimens. PCR assays were used for the detection of adenovirus, Borrelia burgdorferi, enteroviruses, Epstein Barr virus, cytomegalovirus, herpes simplex virus, human herpes virus type 6, JC virus, Leptospira interrogans, Listeria monocytogenes, lymphocytic choriomeningitis virus, measles virus, mumps virus, Mycobacterium sp., Mycoplasma pneumoniae, Toxoplasma gondii and varicella zoster virus. Of the 383 specime

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Havlicek, David F., Jonathan B. Rosenberg, Bishnu P. De, et al. "Cocaine vaccine dAd5GNE protects against moderate daily and high-dose “binge” cocaine use." PLOS ONE 15, no. 11 (2020): e0239780. http://dx.doi.org/10.1371/journal.pone.0239780.

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The cocaine vaccine dAd5GNE is comprised of a disrupted serotype 5 adenovirus gene therapy vector covalently conjugated to the cocaine analog GNE. The vaccine evokes a high titer of circulating anti-cocaine antibodies that prevent cocaine from reaching its cognate receptors in the central nervous system. Prior studies have demonstrated the efficacy of dAd5GNE in models of occasional, moderate cocaine use. However, previous studies have not sufficiently evaluated the efficacy of dAd5GNE in models of the repetitive and high-dose “binge” use patterns common in human addicts. In the present study,

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Patel, Kaushik P., William G. Mayhan, Keshore R. Bidasee, and Hong Zheng. "Enhanced angiotensin II-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 300, no. 2 (2011): R311—R320. http://dx.doi.org/10.1152/ajpregu.00246.2010.

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Studies have shown that the superoxide mechanism is involved in angiotensin II (ANG II) signaling in the central nervous system. We hypothesized that ANG II activates sympathetic outflow by stimulation of superoxide anion in the paraventricular nucleus (PVN) of streptozotocin (STZ)-induced diabetic rats. In α-chloralose- and urethane-anesthetized rats, microinjection of ANG II into the PVN (50, 100, and 200 pmol) produced dose-dependent increases in renal sympathetic nerve activity (RSNA), arterial pressure (AP), and heart rate (HR) in control and STZ-induced diabetic rats. There was a potenti

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Pushchina, Evgeniya V., Ilya A. Kapustyanov, Ekaterina V. Shamshurina, and Anatoly A. Varaksin. "A Confocal Microscopic Study of Gene Transfer into the Mesencephalic Tegmentum of Juvenile Chum Salmon, Oncorhynchus keta, Using Mouse Adeno-Associated Viral Vectors." International Journal of Molecular Sciences 22, no. 11 (2021): 5661. http://dx.doi.org/10.3390/ijms22115661.

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To date, data on the presence of adenoviral receptors in fish are very limited. In the present work, we used mouse recombinant adeno-associated viral vectors (rAAV) with a calcium indicator of the latest generation GCaMP6m that are usually applied for the dorsal hippocampus of mice but were not previously used for gene delivery into fish brain. The aim of our work was to study the feasibility of transduction of rAAV in the mouse hippocampus into brain cells of juvenile chum salmon and subsequent determination of the phenotype of rAAV-labeled cells by confocal laser scanning microscopy (CLSM).

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Zhang, Zhongming, Yijing Zhang, Yan Wang, et al. "Genetic knockdown of brain-derived neurotrophic factor in the nervous system attenuates angiotensin II-induced hypertension in mice." Journal of the Renin-Angiotensin-Aldosterone System 20, no. 1 (2019): 147032031983440. http://dx.doi.org/10.1177/1470320319834406.

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Introduction: Brain-derived neurotropic factor (BDNF) is expressed throughout the central nervous system and peripheral organs involved in the regulation of blood pressure, but the systemic effects of BDNF in the control of blood pressure are not well elucidated. Materials and methods: We utilized loxP flanked BDNF male mice to cross with nestin-Cre female mice to generate nerve system BDNF knockdown mice, nestin-BDNF (+/–), or injected Cre adenovirus into the subfornical organ to create subfornical organ BDNF knockdown mice. Histochemistry was used to verify injection location. Radiotelemetry

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Marcondes, Maria Cecilia Garibaldi, Ryan Ojakian, Nikki Bortell, Claudia Flynn, Bruno Conti, and Howard S. Fox. "Osteopontin Expression in the Brain Triggers Localized Inflammation and Cell Death When Immune Cells Are Activated by Pertussis Toxin." Mediators of Inflammation 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/358218.

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Upregulation of osteopontin (OPN) is a characteristic of central nervous system pathologies. However, the role of OPN in inflammation is still controversial, since it can both prevent cell death and induce the migration of potentially damaging inflammatory cells. To understand the role of OPN in inflammation and cell survival, we expressed OPN, utilizing an adenoviral vector, in the caudoputamen of mice deficient in OPN, using beta-galactosidase- (β-gal-) expressing vector as control. The tissue pathology and the expression of proinflammatory genes were compared in both treatments. Interesting

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Conde-Sieira, Marta, Valentina Capelli, Rosa Álvarez-Otero та ін. "Hypothalamic AMPKα2 regulates liver energy metabolism in rainbow trout through vagal innervation". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 318, № 1 (2020): R122—R134. http://dx.doi.org/10.1152/ajpregu.00264.2019.

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Hypothalamic AMPK plays a major role in the regulation of whole body metabolism and energy balance. Present evidence has demonstrated that this canonical mechanism is evolutionarily conserved. Thus, recent data demonstrated that inhibition of AMPKα2 in fish hypothalamus led to decreased food intake and liver capacity to use and synthesize glucose, lipids, and amino acids. We hypothesize that a signal of abundance of nutrients from the hypothalamus controls hepatic metabolism. The vagus nerve is the most important link between the brain and the liver. We therefore examined in the present study

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Suplicy, Henrique de Lacerda, and Andressa Bornschein. "Infeccions as the etiology for obesity." Arquivos Brasileiros de Endocrinologia & Metabologia 53, no. 2 (2009): 159–64. http://dx.doi.org/10.1590/s0004-27302009000200007.

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The role of infection on obesity development has been questioned since the early 1980's. Several studies on animals have shown that fisiopathologic mechanisms through which infections can produce obesity do exist. At least eight types of obesity-inducing viruses have been identified in animals, especially poultry and mice. Studies on humans are far less convincing; however, two adenoviruses, Ad-36 and SMAM-1, have shown adipogenic properties. In vitro studies with 3T3-L1 cells stated the activation of the enzymatic pathway that leads to fatty tissue accumulation; in vivo studies have also dete

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Cauthen, Angela N., Corrie C. Brown, and Katherine R. Spindler. "In Vitro and In Vivo Characterization of a Mouse Adenovirus Type 1 Early Region 3 Null Mutant." Journal of Virology 73, no. 10 (1999): 8640–46. http://dx.doi.org/10.1128/jvi.73.10.8640-8646.1999.

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ABSTRACT Previous attempts to construct a mouse adenovirus type 1 early region 3 (E3) null mutant by initiator codon mutagenesis were unsuccessful because one of the E3 proteins, gp11K, is synthesized as a fusion protein from a late viral mRNA (A. N. Cauthen and K. R. Spindler, Virology 259:119–128, 1999). Therefore, a different mutagenesis strategy was employed that inserted termination codons into all three reading frames of the E3 proteins. This strategy produced a mutant, pmE314, that was null for the expression of E3 proteins as determined by immunoprecipitation with E3-specific antisera.

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Charles, Peter C., Xia Chen, Marshall S. Horwitz, and Celia F. Brosnan. "Differential chemokine induction by the mouse adenovirus type-1 in the central nervous system of susceptible and resistant strains of mice." Journal of Neurovirology 5, no. 1 (1999): 55–64. http://dx.doi.org/10.3109/13550289909029746.

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46

Sakai, Masashi, Kouichi Tamura, Yuko Tsurumi, et al. "Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression." American Journal of Physiology-Renal Physiology 292, no. 5 (2007): F1526—F1536. http://dx.doi.org/10.1152/ajprenal.00451.2006.

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MAK-V/Hunk is an SNF1-related serine/threonine kinase which was previously shown to be highly expressed in the mammary gland and central nervous system. In this study, we found MAK-V/Hunk is abundantly and specifically expressed in the thick ascending limbs and distal convoluted tubules (DCT) of the kidney from the embryonic stage to the adult stage. We demonstrated that dietary salt depletion significantly enhances renal MAK-V/Hunk mRNA levels compared with a normal-salt diet. To analyze the possible renal cellular function of this kinase, we employed mouse distal convoluted tubule (mDCT) cel

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Reetz, Julia, Steve Hildebrandt, Anke Schmidt, et al. "Novel subventricular zone early progenitor cell-specific adenovirus for in vivo therapy of central nervous system disorders reinforces brain stem cell heterogeneity." Brain Structure and Function 221, no. 4 (2015): 2049–59. http://dx.doi.org/10.1007/s00429-015-1025-8.

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Lindley, Timothy E., David W. Infanger, Mark Rishniw, et al. "Scavenging superoxide selectively in mouse forebrain is associated with improved cardiac function and survival following myocardial infarction." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 296, no. 1 (2009): R1—R8. http://dx.doi.org/10.1152/ajpregu.00078.2008.

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Dysregulation in central nervous system (CNS) signaling that results in chronic sympathetic hyperactivity is now recognized to play a critical role in the pathogenesis of heart failure (HF) following myocardial infarction (MI). We recently demonstrated that adenovirus-mediated gene transfer of cytoplasmic superoxide dismutase (Ad-Cu/ZnSOD) to forebrain circumventricular organs, unique sensory structures that lack a blood-brain barrier and link peripheral blood-borne signals to central nervous system cardiovascular circuits, inhibits both the MI-induced activation of these central signaling pat

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Xue, Baojian, Zhongming Zhang, Terry G. Beltz, Fang Guo, Meredith Hay, and Alan Kim Johnson. "Genetic knockdown of estrogen receptor-alpha in the subfornical organ augments ANG II-induced hypertension in female mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308, no. 6 (2015): R507—R516. http://dx.doi.org/10.1152/ajpregu.00406.2014.

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The present study tested the hypotheses that 1) ERα in the brain plays a key role in the estrogen-protective effects against ANG II-induced hypertension, and 2) that the subfornical organ (SFO) is a key site where ERα mediates these protective actions. In this study, a “floxed” ERα transgenic mouse line (ERαflox) was used to create models in which ERα was knocked down in the brain or just in the SFO. Female mice with ERα ablated in the nervous system (Nestin-ERα− mice) showed greater increases in blood pressure (BP) in response to ANG II. Furthermore, females with ERα knockdown specifically in

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Croxford, J. Ludovic, Marc Feldmann, Yuti Chernajovsky, and David Baker. "Different Therapeutic Outcomes in Experimental Allergic Encephalomyelitis Dependant Upon the Mode of Delivery of IL-10: A Comparison of the Effects of Protein, Adenoviral or Retroviral IL-10 Delivery into the Central Nervous System." Journal of Immunology 166, no. 6 (2001): 4124–30. http://dx.doi.org/10.4049/jimmunol.166.6.4124.

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