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Journal articles on the topic 'ADH1B Polymorphism'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Yin, Guang, Keizo Ohnaka, Makiko Morita, Shinji Tabata, Osamu Tajima, and Suminori Kono. "Genetic Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase: Alcohol Use and Type 2 Diabetes in Japanese Men." Epidemiology Research International 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/583682.

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This study investigated the association of ADH1B (rs1229984) and ALDH2 (rs671) polymorphisms with glucose tolerance status, as determined by a 75-g oral glucose tolerance test, and effect modification of these polymorphisms on the association between alcohol consumption and glucose intolerance in male officials of the Self-Defense Forces. The study subjects included 1520 men with normal glucose tolerance, 553 with prediabetic condition (impaired fasting glucose and impaired glucose tolerance), and 235 men with type 2 diabetes. There was an evident interaction between alcohol consumption and AD

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Chien, Tsuo-Hsuan, Chih-Lang Lin, Li-Wei Chen, Cheng-Hung Chien, and Ching-Chih Hu. "Patients with Non-Alcoholic Fatty Liver Disease and Alcohol Dehydrogenase 1B/Aldehyde Dehydrogenase 2 Mutant Gene Have Higher Values of Serum Alanine Transaminase." Journal of Personalized Medicine 13, no. 5 (2023): 758. http://dx.doi.org/10.3390/jpm13050758.

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Patients with non-alcoholic fatty liver disease (NAFLD) share similar pathophysiologies to those of patients with alcohol liver disease. Alcoholic metabolic enzyme-related genes (alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2)) may be associated with pathophysiology in NAFLD patients. In this study, the association between ADH1B/ALDH2 gene polymorphism and serum metabolic factors, body statures, and hepatic steatosis/fibrosis status was evaluated in patients with NAFLD. Using biochemistry data, abdominal ultrasonography, fibrosis evaluation (Kpa), and steatosis evaluation

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3

Pecikoza, Amar, Lejla Lasic, Gabrijela Radosavljević, et al. "Frequency of ADH1B RsaI (rs2066701) single nucleotide polymorphism in a population of Bosnia and Herzegovina." Genetics & Applications 2, no. 2 (2018): 28. http://dx.doi.org/10.31383/ga.vol2iss2pp28-34.

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Apart from its physiological role in the cellular oxidation of ethanol interesting feature of the ADH1B gene locus is its characteristic geographical distribution in which certain variants of ADH1B peak in different parts of the world. Therefore, ADH1B rs2066701 polymorphism is exploited as a genetic marker in tracing of the evolutionary processes and human migrations in the past. Taking into consideration the complexity of population genetic structure and several migrations in the history of the Balkan populations, including Bosnian and Herzegovinian, this study aimed to estimate the frequenc

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Gu, Sheng, Hui Li, Andrew Pakstis, et al. "Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews." Genes 9, no. 9 (2018): 452. http://dx.doi.org/10.3390/genes9090452.

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The derived human alcohol dehydrogenase (ADH)1B*48His allele of the ADH1B Arg48His polymorphism (rs1229984) has been identified as one component of an East Asian specific core haplotype that underwent recent positive selection. Our study has been extended to Southwest Asia and additional markers in East Asia. Fst values (Sewall Wright’s fixation index) and long-range haplotype analyses identify a strong signature of selection not only in East Asian but also in Southwest Asian populations. However, except for the ADH2B*48His allele, different core haplotypes occur in Southwest Asia compared to

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5

Kukowka, Arnold, Bogusław Brzuchalski, Mateusz Kurzawski, Damian Malinowski, and Monika Anna Białecka. "ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder." Genes 14, no. 7 (2023): 1392. http://dx.doi.org/10.3390/genes14071392.

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Increasing alcohol consumption by women of childbearing age contributes to more frequent cases of fetal alcohol spectrum disorder. The cause of the syndrome is fetal alcohol exposure, particularly what is referred to as high prenatal alcohol exposure. Low metabolic activity of fetal enzymes shifts the burden of ethanol removal to maternal metabolism. One of the factors influencing the pathogenesis of FASD is the genetic background. It can determine the rate of elimination of ethanol, thus increasing or decreasing the time of fetal exposure to ethanol and also decreasing its concentration. Gene

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6

Chen, Yi-Chyan, Li-Fang Yang, Ching-Long Lai, and Shih-Jiun Yin. "Acetaldehyde Enhances Alcohol Sensitivity and Protects against Alcoholism: Evidence from Alcohol Metabolism in Subjects with Variant ALDH2*2 Gene Allele." Biomolecules 11, no. 8 (2021): 1183. http://dx.doi.org/10.3390/biom11081183.

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Alcoholism is a complex behavior trait influenced by multiple genes as well as by sociocultural factors. Alcohol metabolism is one of the biological determinants that can significantly influence drinking behaviors. Alcohol sensitivity is thought to be a behavioral trait marker for susceptibility to develop alcoholism. The subjective perceptions would be an indicator for the alcohol preference. To investigate alcohol sensitivity for the variants ADH1B*2 and ALDH2*2, sixty healthy young males with different combinatory ADH1B and ALDH2 genotypes, ADH1B*2/*2–ALDH2*1/*1 (n = 23), ADH1B*2/*2–ALDH2*1

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7

Bhutia, Yazum, Sanjiba Dutta, and Mingma Sherpa. "Asian flushing, ADH1B, aldehyde dehydrogenase 2 genotypic status among the unique ethnic population of the Himalayan state of Sikkim, India." Asian Journal of Medical Sciences 15, no. 12 (2024): 64–69. https://doi.org/10.71152/ajms.v15i12.4258.

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Background: Alcohol induced flushing a phenotypic instrument variable also known as “Asian flush” was first reported by Wolff (1972), commonly seen among East Asians. This phenotype is indicative of inactive aldehyde dehydrogenase 2 (ALDH2) and high activity of alcohol dehydrogenase (ADH1B). Aims and Objectives: This study aimed to examine the sensitivity and specificity of the simple flushing questionnaire for identifying inactive ALDH2 and to examine the flushing, ADH1B and ALDH2 status across the three unique ethnic groups in Sikkim, India. Materials and Methods: Two hundred and fifty conse

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Bhutia, Yazum, Sanjiba Dutta, and Mingma Lhamu Sherpa. "Asian flushing, ADH1B, aldehyde dehydrogenase 2 genotypic status among the unique ethnic population of the Himalayan state of Sikkim, India." Asian Journal of Medical Sciences 15, no. 12 (2024): 64–69. https://doi.org/10.3126/ajms.v15i12.70143.

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Background: Alcohol induced flushing a phenotypic instrument variable also known as “Asian flush” was first reported by Wolff (1972), commonly seen among East Asians. This phenotype is indicative of inactive aldehyde dehydrogenase 2 (ALDH2) and high activity of alcohol dehydrogenase (ADH1B). Aims and Objectives: This study aimed to examine the sensitivity and specificity of the simple flushing questionnaire for identifying inactive ALDH2 and to examine the flushing, ADH1B and ALDH2 status across the three unique ethnic groups in Sikkim, India. Materials and Methods: Two hundred and fifty conse

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9

Kawashima, Nozomu, Atsushi Narita, Xinan Wang, et al. "ALDH2 Polymorphism In Japanese Children With Acquired Aplastic Anemia." Blood 122, no. 21 (2013): 3717. http://dx.doi.org/10.1182/blood.v122.21.3717.3717.

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Abstract Introduction Aplastic anemia is a syndrome of bone marrow failure (BMF) characterized by peripheral pancytopenia and marrow hypoplasia. Injury to hematopoietic cells, such as immune-mediated cytotoxicity, can cause aplastic anemia; the successful treatment of aplastic anemia using immunosuppressive therapy supports this hypothesis. Another proposed mechanism is an intrinsic defect of hematopoietic stem cells, which is the presumed major cause of congenital BMF, but this mechanism has not been definitively established in patients with acquired aplastic anemia. Aldehyde dehydrogenase 2

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10

Jiang, Shupeng, Yongqing Tong, Rui Zhao, Ge Xiong, Bin Qiao, and Yan Li. "An improved PCR-CTPP assay for the detection of ADH1B Arg48His polymorphism." Journal of Clinical Laboratory Analysis 32, no. 2 (2017): e22268. http://dx.doi.org/10.1002/jcla.22268.

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Borinskaya, S. A., F. Gasemianrodsari, N. R. Kalyina, M. V. Sokolova, and N. K. Yankovsky. "Polymorphism of Alcohol Dehydrogenase Gene ADH1B in Eastern Slavic and Iranian-Speaking Populations." Russian Journal of Genetics 41, no. 11 (2005): 1291–94. http://dx.doi.org/10.1007/s11177-005-0231-5.

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12

Tóth, Réka, Szilvia Fiatal, Beáta Petrovski, Martin McKee, and Róza Ádány. "Combined Effect of ADH1B RS1229984, RS2066702 and ADH1C RS1693482/ RS698 Alleles on Alcoholism and Chronic Liver Diseases." Disease Markers 31, no. 5 (2011): 267–77. http://dx.doi.org/10.1155/2011/350528.

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The aim of this study was to analyze the combined effect of the most frequent alcohol dehydrogenase polymorphisms (Arg48His and Arg370Cys in ADH1B, Arg272Gln and Ile350Val in ADH1C) on the alcohol use habits, alcohol dependence and chronic liver diseases in Hungary.The study included men, aged 45–64 years. Altogether, 241 cases with chronic liver disease (CLD) and 666 randomly selected controls without CLD were analysed for all four polymorphisms. Associations between the polymorphisms, individually, and in combination, and excessive and problem drinking and CLD, were assessed using logistic r

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13

Yao, Chung-Tay, Chun-An Cheng, Hsu-Kun Wang, et al. "The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese." Human Genomics 5, no. 6 (2011): 569. http://dx.doi.org/10.1186/1479-7364-5-6-569.

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14

Peng, Yi, Hong Shi, Xue-bin Qi, et al. "The ADH1B Arg47His polymorphism in East Asian populations and expansion of rice domestication in history." BMC Evolutionary Biology 10, no. 1 (2010): 15. http://dx.doi.org/10.1186/1471-2148-10-15.

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15

Pham, Khanh Ha, and Jaroslav A. Hubáček. "Selected Genetic Characteristics of the Vietnamese Minority Living in the Czech Republic." Folia Biologica 71, no. 1 (2025): 1–7. https://doi.org/10.14712/fb2025071010001.

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The aim of this study was to analyse the allelic distribution of selected genes in the Czech and Vietnamese populations. We analysed samples from 94 Vietnamese volunteers and 2,859 Czech population-based subjects (2,559 from the Czechs post-MONICA and 300 volunteers from the South region of the Czech Republic). There were significant differences between the two populations for most, but not all, of the SNPs analysed. In particular, the prevalence of risk alleles in the analysed polymorphisms tended to be lower in the Vietnamese community compared to the Czech population, especially within the

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16

Marussin, A. V., V. A. Stepanov, M. G. Spiridonova, V. A. Khar’kov, J. R. Pel’s, and V. P. Puzyrev. "Association analysis of alcohol metabolizing enzymes ADH1B, ADH7, CYP2E1 gene polymorphism with risk for coronary atherosclerosis." Russian Journal of Genetics 43, no. 3 (2007): 323–29. http://dx.doi.org/10.1134/s1022795407030155.

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17

Hubacek, Jaroslav A., Hynek Pikhart, Anne Peasey, Ruzena Kubinova, and Martin Bobak. "ADH1B Polymorphism, Alcohol Consumption, and Binge Drinking in Slavic Caucasians: Results from the Czech HAPIEE Study." Alcoholism: Clinical and Experimental Research 36, no. 5 (2011): 900–905. http://dx.doi.org/10.1111/j.1530-0277.2011.01680.x.

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18

Almeida, O. P., G. J. Hankey, B. B. Yeap, J. Golledge, and L. Flicker. "The triangular association of ADH1B genetic polymorphism, alcohol consumption and the risk of depression in older men." Molecular Psychiatry 19, no. 9 (2013): 995–1000. http://dx.doi.org/10.1038/mp.2013.117.

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19

Justice, Amy C., Kathleen A. McGinnis, Janet P. Tate, et al. "Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B." Alcoholism: Clinical and Experimental Research 41, no. 5 (2017): 998–1003. http://dx.doi.org/10.1111/acer.13373.

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20

Imatoh, Takuya, Loic Yengo, Ghislain Rocheleau, et al. "ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers." Lipids 53, no. 8 (2018): 797–807. http://dx.doi.org/10.1002/lipd.12087.

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21

Solopekin, N. V. "An estimate of polymorphism of ADH1B, ALDH2, and CYP2E1 alcohol biotransformation genes in Siberian indigenous and immigrant populations." Moscow University Biological Sciences Bulletin 66, no. 2 (2011): 71–72. http://dx.doi.org/10.3103/s0096392511020088.

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22

Wang, Tzu-Yun, Sheng-Yu Lee, Shiou-Lan Chen, et al. "The ADH1B and DRD2 gene polymorphism may modify the protective effect of the ALDH2 gene against heroin dependence." Progress in Neuro-Psychopharmacology and Biological Psychiatry 43 (June 2013): 134–39. http://dx.doi.org/10.1016/j.pnpbp.2012.12.011.

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23

Melo, Anne Jurkiewicz, Jefferson Almeida Rocha, Mônika Machado de Carvalho, et al. "Allelic variations in alcohol metabolism genes (ADH1B, ADH1C, CYP2E1) and alcohol use disorder (AUD) in northeastern Brazil." Research, Society and Development 11, no. 13 (2022): e477111335486. http://dx.doi.org/10.33448/rsd-v11i13.35486.

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Alcohol use disorder (AUD) is a multifactorial disease caused by environmental and genetic factors. Genetic polymorphisms of the enzymes involved in alcohol metabolism influence the susceptibility to alcohol dependence. The distribution of the genetic variants varies depending on ethnicity. The aim of this study was to evaluate the effects of the polymorphisms of the three genes responsible for the degradation of ethanol, ADH1B, ADH1C, and CYP2E1 to examine the influence of these mutations on the risk for alcohol use disorder in a population from northeastern Brazil. In addition, the allelic d

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24

Castaldelli-Maia, João M., André Malbergier, Adriana B. P. de Oliveira, et al. "Exploring the Role of Alcohol Metabolizing Genotypes in a 12-Week Clinical Trial of Naltrexone for Alcohol Use Disorder." Biomolecules 11, no. 10 (2021): 1495. http://dx.doi.org/10.3390/biom11101495.

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Background: The efficacy of naltrexone in the treatment of alcohol use disorder (AUD) has been associated with a set of variables not directly related with the expression of opioid receptors. All the variables have been found to be highly associated with AUD itself or more severe clinical levels of AUD. Objectives: Given the high association between alcohol metabolizing enzymes (AME) and the outcome of AUD, the present study aims to investigate the role of AME genotype variants in the treatment of AUD with naltrexone. Methods: We carried out a 12-week longitudinal clinical trial based on the t

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25

Zhang, Guohong, Ruiqin Mai, and Bo Huang. "ADH1B Arg47His Polymorphism Is Associated with Esophageal Cancer Risk in High-Incidence Asian Population: Evidence from a Meta-Analysis." PLoS ONE 5, no. 10 (2010): e13679. http://dx.doi.org/10.1371/journal.pone.0013679.

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26

Mohelnikova-Duchonova, Beatrice, David Vrana, Ivana Holcatova, Miroslav Ryska, Zdenek Smerhovsky, and Pavel Soucek. "CYP2A13, ADH1B, and ADH1C Gene Polymorphisms and Pancreatic Cancer Risk." Pancreas 39, no. 2 (2010): 144–48. http://dx.doi.org/10.1097/mpa.0b013e3181bab6c2.

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Birley, A. J., J. B. Whitfield, M. C. Neale, et al. "Genetic Time-series Analysis Identifies a Major QTL for in vivo Alcohol Metabolism not Predicted by in vitro Studies of Structural Protein Polymorphism at the ADH1B or ADH1C Loci." Behavior Genetics 35, no. 5 (2005): 509–24. http://dx.doi.org/10.1007/s10519-005-3851-6.

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Chen, Che-Hong, Wen-Lun Wang, Ming-Hung Hsu, and Daria Mochly-Rosen. "Alcohol Consumption, ALDH2 Polymorphism as Risk Factors for Upper Aerodigestive Tract Cancer Progression and Prognosis." Life 12, no. 3 (2022): 348. http://dx.doi.org/10.3390/life12030348.

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The upper aerodigestive tract (UADT) is highly susceptible to multiple primary cancers originated from squamous epithelia and constitutes a field of cancerization. Patients with head and neck cancer (head and neck squamous cell carcinoma, HNSCC) are at high risk of developing multiple cancers in the esophagus (esophageal squamous cell carcinoma, ESCC). Conversely, esophageal cancer patients are prone to develop multiple primary tumors in the head and neck region. The East Asian-specific dysfunctional ALDH2*2 missense mutation is a genetic risk factor for UADT cancer. It is not only associated

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Noormaningrum, Budiatri Retno, Yudha Nurhantari, Suhartini Suhartini, Tri Ratnaningsih, and Maria Agnes Etty Dedy. "Alcohol dehydrogenase 1C (ADH1C) polymorphism is significantly associated with kidney function status in Nusa Tenggara Timur ethnicity: A cross-sectional study." Journal of Community Empowerment for Health 4, no. 3 (2021): 162. http://dx.doi.org/10.22146/jcoemph.61561.

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Excessive alcohol consumption is harmful to many human organs, but the association with kidney function is still controversial. The disagreement in findings might be caused by ADH1C polymorphism's influence on alcohol metabolism rate. This study aims to determine the correlation between ADH1C polymorphism and kidney function status in Nusa Tenggara Timur (NTT) ethnicity, a population with highly prevalent alcohol consumption in Indonesia. We conducted a cross-sectional study of 76 subjects, who are natives of NTT, Indonesia. The genotyping of extracted DNA for ADH1C was done by polymerase chai

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Muharram, F., K. Listyarini, C. Sumantri, C. Budiman, and A. Gunawan. "Identification of the ADH1C|FspI gene polymorphism and its association with flavor and odor in Indonesian local sheep." IOP Conference Series: Earth and Environmental Science 1341, no. 1 (2024): 012018. http://dx.doi.org/10.1088/1755-1315/1341/1/012018.

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Abstract Sheep meat’s flavor and odor may not be as appealing to Indonesians, necessitating genetic improvements in these aspects. The ADH1C (Alcohol Dehydrogenase 1C) gene significantly influences the conversion of ethanol to acetate in liver tissue, directly impacting sheep meat’s flavor and odor. The purpose of this study was to see how ADH1C gene polymorphisms affected sheep meat flavor and odor in Indonesian sheep. The study utilized a sample of 100 rams, including 10 Javanese fat-tailed (JFT), 78 Javanese thin-tailed (JTT), and 12 Jonggol sheep (JS), all aged between 10 and 12 months. To

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van Beek, Jenny H. D. A., Gonneke Willemsen, Marleen H. M. de Moor, Jouke Jan Hottenga, and Dorret I. Boomsma. "Associations Between ADH Gene Variants and Alcohol Phenotypes in Dutch Adults." Twin Research and Human Genetics 13, no. 1 (2010): 30–42. http://dx.doi.org/10.1375/twin.13.1.30.

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AbstractRecently, Macgregor et al. (2009) demonstrated significant associations of ADH polymorphisms with reactions to alcohol and alcohol consumption measures in an Australian sample. The aim of the present study was to replicate these findings in a Dutch sample. Survey data on alcohol phenotypes came from 1,754 unrelated individuals registered with the Netherlands Twin Register. SNPs in the ADH gene cluster located on chromosome 4q (n= 491) were subdivided in seven gene sets: ADH5, ADH4, ADH6, ADH1A, ADH1B, ADH1C and ADH7. Within these sets associations of SNPs with alcohol consumption measu

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Ji, Yong Bae, Seung Hwan Lee, Kyung Rae Kim, et al. "Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma." Tumor Biology 36, no. 6 (2015): 4387–96. http://dx.doi.org/10.1007/s13277-015-3078-y.

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Wang, Jiwen, Jinyu Wei, Xiaoling Xu, et al. "Replication Study of ESCC Susceptibility Genetic Polymorphisms Locating in the ADH1B-ADH1C-ADH7 Cluster Identified by GWAS." PLoS ONE 9, no. 4 (2014): e94096. http://dx.doi.org/10.1371/journal.pone.0094096.

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Gaut, B. S., and M. T. Clegg. "Nucleotide polymorphism in the Adh1 locus of pearl millet (Pennisetum glaucum) (Poaceae)." Genetics 135, no. 4 (1993): 1091–97. http://dx.doi.org/10.1093/genetics/135.4.1091.

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Abstract We investigated nucleotide polymorphism in the Adh1 locus of pearl millet (Pennisetum glaucum) (Poaceae) by determining the DNA sequence of 20 alleles from 10 individuals. The individuals were sampled from throughout pearl millet's indigenous range and represent both wild and cultivated accessions. Our results indicated that there is little nucleotide polymorphism in the Adh1 locus. Estimates of per site nucleotide polymorphism did not differ significantly between cultivated and wild millet accessions. We compared nucleotide polymorphism in pearl millet Adh1 with nucleotide polymorphi

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Hoang, Yen, Yen Nguyen, Hai Nguyen, et al. "Single Nucleotide Polymorphisms of ADH1B, ADH1C and ALDH2 Genes in 235 People Living in Thai Nguyen Province of Vietnam." Asian Pacific Journal of Cancer Prevention 23, no. 12 (2022): 4243–51. http://dx.doi.org/10.31557/apjcp.2022.23.12.4243.

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Filopanti, M., A. M. Barbieri, G. Mantovani, et al. "Role of UGT1A1 and ADH gene polymorphisms in pegvisomant-induced liver toxicity in acromegalic patients." European Journal of Endocrinology 170, no. 2 (2014): 247–54. http://dx.doi.org/10.1530/eje-13-0657.

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ContextHepatotoxicity is one of the most serious adverse effects in acromegalic patients treated with pegvisomant (PEG-V). Recent studies have found an association between this adverse event and the UGT1A1 allele 28 polymorphism associated with Gilbert's syndrome.ObjectiveTo determine whether UGT1A1*28 and alcohol dehydrogenase (ADH) polymorphisms influence liver toxicity during PEG-V treatment.Design and settingMulticenter observational retrospective study conducted in 13 tertiary care endocrinology units in Italy.PatientsA total of 112 patients with active disease resistant to somatostatin a

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Wakabayashi, Ichiro, Harald Sourij, Yoko Sotoda, Takashi Daimon, Klaus Groschner, and Peter P. Rainer. "Ethnic Differences in Serum Levels of microRNAs Potentially Regulating Alcohol Dehydrogenase 1B and Aldehyde Dehydrogenase 2." Journal of Clinical Medicine 10, no. 16 (2021): 3678. http://dx.doi.org/10.3390/jcm10163678.

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Ethnic difference is known in genetic polymorphisms of aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B), which cause Asian flushing by blood vessel dilation due to accumulation of acetaldehyde. We investigated ethnic differences in microRNAs (miRNAs) related to ALDH2 and ADH1B. miRNA levels in serum were totally analyzed by using miRNA oligo chip arrays and compared in Austrian and Japanese middle-aged men. There were no ALDH2- and ADH1B-related miRNAs that had previously been reported in humans and that showed significantly different serum levels between Austrian and Japa

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Yokoyama, Akira, Tetsuji Yokoyama, Mitsuru Kimura, Sachio Matsushita, and Masako Yokoyama. "Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women." PLOS ONE 16, no. 7 (2021): e0255276. http://dx.doi.org/10.1371/journal.pone.0255276.

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Objective The risk of alcohol dependence (AD) in Japanese men and women was evaluated according to combinations of alcohol flushing and aldehyde dehydrogenase-2 (ALDH2, rs671) and alcohol dehydrogenase-1B (ADH1B, rs1229984) genotypes, all of which are known to determine AD susceptibility in Asians. Previous studies have focused on men, since women account for a smaller proportion of AD subjects. Methods Case control studies were conducted between 3721 male and 335 female AD Japanese and 610 male and 406 female controls who were asked about their current or former tendency to experience facial

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Hidaka, Akihisa, Shizuka Sasazuki, Keitaro Matsuo, et al. "Genetic polymorphisms of ADH1B, ADH1C and ALDH2, alcohol consumption, and the risk of gastric cancer: the Japan Public Health Center-based prospective study." Carcinogenesis 36, no. 2 (2014): 223–31. http://dx.doi.org/10.1093/carcin/bgu244.

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Kouichi, Yoshimasu. "Depression, Alcoholism, and Genetic Alcohol Sensitivity Regulated by ALDH2 and ADH1B Polymorphisms among Japanese Community-Dwelling Adults." Archives of Depression and Anxiety 2, no. 1 (2016): 037–43. https://doi.org/10.17352/2455-5460.000013.

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<strong>Background</strong>: Although strong association between drinking and depression as well as alcohol- related disorders (ARD) has been reported, the relationship between potential ability to drink (genetic alcohol sensitivity) and depression or ARD is unclear. Genetic alcohol sensitivity is regulated by two alcohol metabolic enzyme genes, ADH1B and ALDH2 polymorphisms. We have already evaluated the  association  between  depression  and  these  polymorphisms  in Japanese white-collar  workers.Current study expanded this issue on community-dwelling

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Sachs, M. M., E. S. Dennis, W. L. Gerlach, and W. J. Peacock. "TWO ALLELES OF MAIZE ALCOHOL DEHYDROGENASE 1 HAVE 3' STRUCTURAL AND POLY(A) ADDITION POLYMORPHISMS." Genetics 113, no. 2 (1986): 449–67. http://dx.doi.org/10.1093/genetics/113.2.449.

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ABSTRACT Two standard electrophoretic alleles of the maize alcohol dehydrogenase 1 locus (Adh1-1S and Adh1-1F) have been isolated and characterized. Restriction endonuclease mapping shows that a region of less than 5 kb is conserved in both alleles and is flanked both 5' and 3' by regions highly polymorphic for restriction sites. Nucleotide sequence comparison of these two alleles reveals that polymorphism in the 3' flanking region is due to rearrangements including tandem duplications, a transposable element-like insertion and a deletion. S1 nuclease analysis shows that both the Adh1-1S and t

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Kimura, Mitsuru, Tomohiro Miyakawa, Sachio Matsushita, Mirai So, and Susumu Higuchi. "Gender Differences in the Effects of ADH1B and ALDH2 Polymorphisms on Alcoholism." Alcoholism: Clinical and Experimental Research 35, no. 11 (2011): 1923–27. http://dx.doi.org/10.1111/j.1530-0277.2011.01543.x.

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Chang, Allison, Semira Ortiz, and Martha Field. "Maternal Alcohol Dehydrogenase 1 Heterozygosity Drives Resistance of Offspring to Weight Gain." Current Developments in Nutrition 6, Supplement_1 (2022): 1109. http://dx.doi.org/10.1093/cdn/nzac078.003.

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Abstract Objectives Prior research has shown that Alcohol Dehydrogenase 1 (ADH1) polymorphisms affect body weight and adiposity. We observed that wild-type mice offspring from heterozygous Adh1 (Adh1+/−) intercrosses were resistant to weight gain. The objective of this study was to determine the mechanisms that underlie this observation. Methods We monitored the body composition of wild-type mice consuming a high-fat diet (60% calories from fat) from three specific parental crosses Adh1+/−dam x Adh1+/−sire (n = 8), Adh1+/−dam crossed with wild type C57Bl/6J (B6) sire (n = 10), and B6 dam x Adh

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Crous-Bou, Marta, Gad Rennert, Daniel Cuadras, et al. "Polymorphisms in Alcohol Metabolism Genes ADH1B and ALDH2, Alcohol Consumption and Colorectal Cancer." PLoS ONE 8, no. 11 (2013): e80158. http://dx.doi.org/10.1371/journal.pone.0080158.

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Marussin, A. V., V. A. Stepanov, M. G. Spiridonova, and V. P. Puzyrev. "Polymorphisms of Alcohol Dehydrogenase Genes ADH1B and ADH7 in Russian Populations of Siberia." Molecular Biology 38, no. 4 (2004): 524–29. http://dx.doi.org/10.1023/b:mbil.0000037004.73229.d3.

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Rebello, André Soares, Rodrigo Moura-Neto, and Maria da Glória da Costa Carvalho. "Association study of the Ile349val polymorphism of the gene ADH1C and alcohol dependence." Jornal Brasileiro de Psiquiatria 60, no. 1 (2011): 7–10. http://dx.doi.org/10.1590/s0047-20852011000100002.

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OBJECTIVE: The aim of this study was to investigate the polymorphism Ile349Val of the enzyme alcohol dehydrogenase ADH1C gene among individuals with alcohol dependence syndrome (ADS) attending Alcoholics Anonymous (AA) meetings. METHODS: A total of 120 subjects residing in Rio de Janeiro city participated in this study. Subjects were divided into two groups: a group consisting of 54 individuals from the ADS group and 66 individuals that declared not having any alcohol dependence (control group). DNA was extracted from mouth epithelial cells by phenol-chloroform method and further submitted to

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Li, Daxu, Ruizhi Zhang, Tianbo Jin, et al. "ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer." Oncotarget 7, no. 45 (2016): 73216–28. http://dx.doi.org/10.18632/oncotarget.12301.

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Kuittinen, Helmi, and Montserrat Aguadé. "Nucleotide Variation at theCHALCONE ISOMERASELocus inArabidopsis thaliana." Genetics 155, no. 2 (2000): 863–72. http://dx.doi.org/10.1093/genetics/155.2.863.

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AbstractAn ~1.9-kb region encompassing the CHI gene, which encodes chalcone isomerase, was sequenced in 24 worldwide ecotypes of Arabidopsis thaliana (L.) Heynh. and in 1 ecotype of A. lyrata ssp. petraea. There was no evidence for dimorphism at the CHI region. A minimum of three recombination events was inferred in the history of the sampled ecotypes of the highly selfing A. thaliana. The estimated nucleotide diversity (θTOTAL = 0.004, θSIL = 0.005) was on the lower part of the range of the corresponding estimates for other gene regions. The skewness of the frequency spectrum toward an excess

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Chen, Jie, Qi Luo, Gen Li, Yumeng Huang, and Jianfang Ma. "Genetic Association Study of Restless Legs Syndrome in Chinese Population." European Neurology 81, no. 1-2 (2019): 47–55. http://dx.doi.org/10.1159/000500416.

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Backgrounds: Several recent case-control studies have suggested some candidate genes being responsible for causing the restless legs syndrome (RLS). However, the association between those genes and the risk for RLS among the Asian population has not been well investigated. Objectives: The aim of the study was to investigate the genetic risk factors of RLS among the Chinese Population. Methods: A total of 158 RLS patients and 229 controls were recruited and the diagnosis of RLS was based on the criteria of International RLS Study Group. Polymer chain reaction and sequencing were used to detect

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Yang, Shu-Juan. "Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: A meta-analysis." World Journal of Gastroenterology 16, no. 33 (2010): 4210. http://dx.doi.org/10.3748/wjg.v16.i33.4210.

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