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Journal articles on the topic 'Adipokine balance'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Rijnsburger, Merel, Niek Djuric, Inge A. Mulder, and Helga E. de Vries. "Adipokines as Immune Cell Modulators in Multiple Sclerosis." International Journal of Molecular Sciences 22, no. 19 (2021): 10845. http://dx.doi.org/10.3390/ijms221910845.

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Multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the central nervous system (CNS), is a major clinical and societal problem, which has a tremendous impact on the life of patients and their proxies. Current immunomodulatory and anti-inflammatory therapies prove to be relatively effective; however, they fail to concomitantly stop ongoing neurological deterioration and do not reverse acquired disability. The proportion to which genetic and environmental factors contribute to the etiology of MS is still incompletely understood; however, a recent association between MS e

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Hoppmann, J., N. Perwitz, B. Meier, et al. "The balance between gluco- and mineralo-corticoid action critically determines inflammatory adipocyte responses." Journal of Endocrinology 204, no. 2 (2009): 153–64. http://dx.doi.org/10.1677/joe-09-0292.

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Obesity is associated with chronic inflammation. Pro-inflammatory adipokines may promote metabolic disorders and cardiovascular morbidity. However, the key mechanisms leading to obesity-related inflammation are poorly understood. The corticosteroid metabolism in adipose tissue plays a crucial role in the pathogenesis of the metabolic syndrome. Both the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) mediate corticosteroid action in adipose tissue. The significance of the interplay of these receptors in mediating an inflammatory adipokine response is virtually unexplored. I

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Nagl, Veronika, Bertrand Grenier, Philippe Pinton, et al. "Exposure to Zearalenone Leads to Metabolic Disruption and Changes in Circulating Adipokines Concentrations in Pigs." Toxins 13, no. 11 (2021): 790. http://dx.doi.org/10.3390/toxins13110790.

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Zearalenone (ZEN) is a mycotoxin classified as an endocrine disruptor. Many endocrine disruptors are also metabolic disruptors able to modulate energy balance and inflammatory processes in a process often involving a family of protein hormones known as adipokines. The aim of our study was to elucidate the role of ZEN as metabolic disruptor in pigs by investigating the changes in energy balance and adipokines levels in response to different treatment diets. To this end, weaned piglets (n = 10/group) were exposed to either basal feed or feed contaminated with 680 and 1620 µg/kg ZEN for 28 days.

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Ge, Qian, Laurence Ryken, Laurence Noel, Eléonore Maury, and Sonia M. Brichard. "Adipokines identified as new downstream targets for adiponectin: lessons from adiponectin-overexpressing or -deficient mice." American Journal of Physiology-Endocrinology and Metabolism 301, no. 2 (2011): E326—E335. http://dx.doi.org/10.1152/ajpendo.00153.2011.

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Adipokines play a central role in the pathogenesis of the metabolic syndrome. Among them, adiponectin (ApN), a master regulator of immune and fuel homeostasis, is decreased. Identifying downstream adipokines targeted by ApN may help in deciphering this syndrome. We have generated transgenic mice, allowing persistent and moderate overexpression of ApN (ApN-Overex) specifically in white adipose tissue (AT). We took advantage of this model to unravel the adipokine secretion profile triggered by ApN. AT was fractionated into adipocytes and stromal-vascular cells (SVC), which were cultured for 8 h.

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Helfer, Gisela, and Qing-Feng Wu. "Chemerin: a multifaceted adipokine involved in metabolic disorders." Journal of Endocrinology 238, no. 2 (2018): R79—R94. http://dx.doi.org/10.1530/joe-18-0174.

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Metabolic syndrome is a global public health problem and predisposes individuals to obesity, diabetes and cardiovascular disease. Although the underlying mechanisms remain to be elucidated, accumulating evidence has uncovered a critical role of adipokines. Chemerin, encoded by the gene Rarres2, is a newly discovered adipokine involved in inflammation, adipogenesis, angiogenesis and energy metabolism. In humans, local and circulating levels of chemerin are positively correlated with BMI and obesity-related biomarkers. In this review, we discuss both peripheral and central roles of chemerin in r

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Ahmed abed, Baydaa, Layla Othman Farhan, Isam Noori Salman, and Safaa Ehssan. "A review on the role of novel adipokine Isthmin-1 and Subfatin in human type 2 diabetes mellitus." University of Thi-Qar Journal of Science 10, no. 2 (2023): 181–86. http://dx.doi.org/10.32792/utq/utjsci/v10i2.1129.

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Adipokines are essential for maintaining cardiovascular and metabolic balance. The term "adipokines" refers to peptides in the pancreas, brain, vascular system, liver, immune system and muscle. adipokines regulate numbers of factors, such as energy expenditure, hunger, satiety, insulin sensitivity, and blood pressure, insulin secretion, adipogenesis and fat distribution, and that might make them play a role in future pharmacological treatment strategies for obesity and metabolic diseases. Isthmin-1 (Ism-1) is a recently discovered insulin-like adipokine that suppresses hepatic lipids. Accordin

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Goralski, Kerry B., and Christopher J. Sinal. "Type 2 diabetes and cardiovascular disease: getting to the fat of the matterThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum." Canadian Journal of Physiology and Pharmacology 85, no. 1 (2007): 113–32. http://dx.doi.org/10.1139/y06-092.

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The increasing national prevalence of obesity is a major public health concern and a substantial burden on the health care resources of Canada. In addition to the direct health impact of obesity, this condition is a well-established risk factor for the development of various prevalent comorbidities including type 2 diabetes, hypertension, and cardiovascular disease. Historically, adipose tissue has been regarded primarily as an organ for energy storage. However, the discovery of leptin in the mid 1990’s revolutionized our understanding of this tissue and has focused attention on the endocrine

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Di Zazzo, Erika, Rita Polito, Silvia Bartollino, et al. "Adiponectin as Link Factor between Adipose Tissue and Cancer." International Journal of Molecular Sciences 20, no. 4 (2019): 839. http://dx.doi.org/10.3390/ijms20040839.

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Adipose tissue is a key regulator of energy balance playing an active role in lipid storage as well as in synthesizing several hormones directly involved in the pathogenesis of obesity. Obesity represents a peculiar risk factor for a growing list of cancers and is frequently associated to poor clinical outcome. The mechanism linking obesity and cancer is not completely understood, but, amongst the major players, there are both chronic low-grade inflammation and deregulation of adipokines secretion. In obesity, the adipose tissue is pervaded by an abnormal number of immune cells that create an

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Donoso, M. A., M. T. Muñoz-Calvo, V. Barrios, G. Garrido, F. Hawkins, and J. Argente. "Increased circulating adiponectin levels and decreased leptin/soluble leptin receptor ratio throughout puberty in female ballet dancers: association with body composition and the delay in puberty." European Journal of Endocrinology 162, no. 5 (2010): 905–11. http://dx.doi.org/10.1530/eje-09-0874.

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IntroductionBallet dancers (BDs) have a negative energy balance related to physical training that results in alterations in body composition, sexual development, and adipokine secretion. Our aims were to study anthropometric parameters, body composition, and their relationship with adipokines throughout pubertal development.Subjects and methodsWe carried out a prospective follow-up study of 22 female Caucasian BDs (Tanner II stage) followed throughout puberty. Nutritional status was determined by measurement of height, weight, and body mass index (BMI). We calculated growth velocity, bone matu

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Frayn, Keith N. "Obesity and metabolic disease: is adipose tissue the culprit?" Proceedings of the Nutrition Society 64, no. 1 (2005): 7–13. http://dx.doi.org/10.1079/pns2004403.

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Obesity is a risk factor for the development of type 2 diabetes and CVD. Is adipose tissue the culprit in the relationship between obesity and metabolic disease? It iscertainly possible to argue that adipose tissue function is disturbed in obesity in sucha way that adverse consequences may follow. For instance, lipolysis is down regulated, the sensitivity of lipolysis to insulin is reduced and there are disturbances in the regulation of adipose tissue blood flow. However, when examined critically these changes canbe seen as adaptations to the increased adipose tissue mass, making the situation

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Bokarewa, Maria I., Malin C. Erlandsson, Jan Bjersing, Mats Dehlin, and Kaisa Mannerkorpi. "Smoking is Associated with Reduced Leptin and Neuropeptide Y Levels and Higher Pain Experience in Patients with Fibromyalgia." Mediators of Inflammation 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/627041.

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Smoking deregulates neuroendocrine responses to pain supporting production of neuropeptide Y (NpY) by direct stimulation of nicotinic receptors or by inhibiting adipokine leptin. Present study addressed the effect of cigarette smoking on adipokines and pain parameters, in 62 women with fibromyalgia (FM) pain syndrome with unknown etiology. Pain was characterized by a visual analogue scale, tender point (TP) counts, pressure pain threshold, and neuroendocrine markers NpY and substance P (sP). Levels of IGF-1, leptin, resistin, visfatin, and adiponectin were measured in blood and cerebrospinal f

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Ernst, Matthew C., Ian D. Haidl, Luis A. Zúñiga, et al. "Disruption of the Chemokine-Like Receptor-1 (CMKLR1) Gene Is Associated with Reduced Adiposity and Glucose Intolerance." Endocrinology 153, no. 2 (2012): 672–82. http://dx.doi.org/10.1210/en.2011-1490.

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Adipose tissue secretes a variety of bioactive signaling molecules, termed adipokines, which regulate numerous biological functions including appetite, energy balance, glucose homeostasis, and inflammation. Chemerin is a novel adipokine that regulates adipocyte differentiation and metabolism by binding to and activating the G protein-coupled receptor, chemokine like receptor-1 (CMKLR1). In the present study, we investigated the impact of CMKLR1 deficiency on adipose development, glucose homeostasis, and inflammation in vivo. Herein we report that regardless of diet (low or high fat), CMKLR1−/−

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Lerner, Avi, Drashti Kewada, Ayan Ahmed, Kate Hardy, Mark Christian, and Stephen Franks. "Androgen Reduces Mitochondrial Respiration in Mouse Brown Adipocytes: A Model for Disordered Energy Balance in Polycystic Ovary Syndrome." International Journal of Molecular Sciences 22, no. 1 (2020): 243. http://dx.doi.org/10.3390/ijms22010243.

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Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is associated with an adverse metabolic profile including reduced postprandial thermogenesis. Although abnormalities in adipose tissue function have been widely reported in women with PCOS, less is known about direct effects of androgen on white and, particularly, brown adipocytes. The purpose of this study was to investigate the effect of the nonaromatizable androgen dihydrotestosterone (DHT) on (1) lipid accumulation and expression of adipogenic markers in immortalized mouse brown adipose cell lines (IMBATs), (2) mitochondrial

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Ge, Q., E. Maury, L. Rycken, et al. "Endocannabinoids regulate adipokine production and the immune balance of omental adipose tissue in human obesity." International Journal of Obesity 37, no. 6 (2012): 874–80. http://dx.doi.org/10.1038/ijo.2012.123.

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Salazar, Juan, Mervin Chávez-Castillo, Joselyn Rojas, et al. "Is “Leptin Resistance” Another Key Resistance to Manage Type 2 Diabetes?" Current Diabetes Reviews 16, no. 7 (2020): 733–49. http://dx.doi.org/10.2174/1573399816666191230111838.

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Although novel pharmacological options for the treatment of type 2 diabetes mellitus (DM2) have been observed to modulate the functionality of several key organs in glucose homeostasis, successful regulation of insulin resistance (IR), body weight management, and pharmacological treatment of obesity remain notable problems in endocrinology. Leptin may be a pivotal player in this scenario, as an adipokine which centrally regulates appetite and energy balance. In obesity, excessive caloric intake promotes a low-grade inflammatory response, which leads to dysregulations in lipid storage and adipo

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Barchetta, Ilaria, Flavia Agata Cimini, Sara Dule, and Maria Gisella Cavallo. "Dipeptidyl Peptidase 4 (DPP4) as A Novel Adipokine: Role in Metabolism and Fat Homeostasis." Biomedicines 10, no. 9 (2022): 2306. http://dx.doi.org/10.3390/biomedicines10092306.

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Dipeptidyl peptidase 4 (DPP4) is a molecule implicated in the regulation of metabolic homeostasis and inflammatory processes, and it exerts its main action through its enzymatic activity. DPP4 represents the enzyme most involved in the catabolism of incretin hormones; thus, its activity impacts appetite, energy balance, and the fine regulation of glucose homeostasis. Indeed, DPP4 inhibitors represent a class of antidiabetic agents widely used for the treatment of Type 2 diabetes mellitus (T2DM). DPP4 also acts as an adipokine and is mainly secreted by the adipose tissue, mostly from mature adi

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Cancel, Mathilde, William Pouillot, Karine Mahéo, Alix Fontaine, David Crottès, and Gaëlle Fromont. "Interplay between Prostate Cancer and Adipose Microenvironment: A Complex and Flexible Scenario." International Journal of Molecular Sciences 23, no. 18 (2022): 10762. http://dx.doi.org/10.3390/ijms231810762.

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Adipose tissue is part of the prostate cancer (PCa) microenvironment not only in the periprostatic area, but also in the most frequent metastatic sites, such as bone marrow and pelvic lymph nodes. The involvement of periprostatic adipose tissue (PPAT) in the aggressiveness of PCa is strongly suggested by numerous studies. Many molecules play a role in the reciprocal interaction between adipocytes and PCa cells, including adipokines, hormones, lipids, and also lipophilic pollutants stored in adipocytes. The crosstalk has consequences not only on cancer cell growth and metastatic potential, but

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Hertzel, Ann V., Lisa Ann Smith, Anders H. Berg, et al. "Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice." American Journal of Physiology-Endocrinology and Metabolism 290, no. 5 (2006): E814—E823. http://dx.doi.org/10.1152/ajpendo.00465.2005.

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Fatty acid-binding proteins (FABPs) facilitate the diffusion of fatty acids within cellular cytoplasm. Compared with C57Bl/6J mice maintained on a high-fat diet, adipose-FABP (A-FABP) null mice exhibit increased fat mass, decreased lipolysis, increased muscle glucose oxidation, and attenuated insulin resistance, whereas overexpression of epithelial-FABP (E-FABP) in adipose tissue results in decreased fat mass, increased lipolysis, and potentiated insulin resistance. To identify the mechanisms that underlie these processes, real-time PCR analyses indicate that the expression of hormone-sensitiv

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Piya, M. K., P. G. McTernan, and S. Kumar. "Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin." Journal of Endocrinology 216, no. 1 (2012): T1—T15. http://dx.doi.org/10.1530/joe-12-0498.

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Adipose tissue is an active endocrine organ, and our knowledge of this secretory tissue, in recent years, has led us to completely rethink how our body functions and becomes dysregulated with weight gain. Human adipose tissue appears to act as a multifunctional secretory organ with the capacity to control energy homoeostasis through peripheral and central regulation of energy homoeostasis. It also plays an important role in innate immunity. However, the capability to more than double its original mass to cope with positive energy balance in obesity leads to many pathogenic changes. These chang

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Miao, Yanli, Haojie Qin, Yi Zhong, Kai Huang, and Caijun Rao. "Novel adipokine asprosin modulates browning and adipogenesis in white adipose tissue." Journal of Endocrinology 249, no. 2 (2021): 83–93. http://dx.doi.org/10.1530/joe-20-0503.

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Obesity is an increasingly serious epidemic worldwide characterized by an increase in the number and size of adipocytes. Adipose tissue maintains the balance between lipid storage and energy utilization. Therefore, adipose metabolism is of great significance for the prevention, treatment and intervention of obesity. Asprosin, a novel adipokine, is a circulating hormone mainly secreted by white adipose tissue. Previous studies have shown that asprosin plays a role in fasting-induced homeostasis, insulin resistance, and glucose tolerance. However, whether it can regulate the metabolism of adipos

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Barbe, Alix, Alice Bongrani, Namya Mellouk, et al. "Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions." International Journal of Molecular Sciences 20, no. 7 (2019): 1526. http://dx.doi.org/10.3390/ijms20071526.

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Adiponectin is the most abundant plasma adipokine. It mainly derives from white adipose tissue and plays a key role in the control of energy metabolism thanks to its insulin-sensitising, anti-inflammatory, and antiatherogenic properties. In vitro and in vivo evidence shows that adiponectin could also be one of the hormones controlling the interaction between energy balance and fertility in several species, including humans. Indeed, its two receptors—AdipoR1 and AdipoR2—are expressed in hypothalamic–pituitary–gonadal axis and their activation regulates Kiss, GnRH and gonadotropin expression and

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de Assis, Gilmara Gomes, and Eugenia Murawska-Ciałowicz. "Exercise and Weight Management: The Role of Leptin—A Systematic Review and Update of Clinical Data from 2000–2022." Journal of Clinical Medicine 12, no. 13 (2023): 4490. http://dx.doi.org/10.3390/jcm12134490.

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A well-balanced metabolism means a lower risk for metabolism-related neuropsychiatric disorders. Leptin is a secretory adipokine involved in the central control of appetite that appears to play a role in the etiology of feeding-related disorders. Additionally, the influence of exercise on feeding behaviors potentially modulates the circulation of metabolites that signal through the central nervous system. In this systematic review, we collected the recent clinical evidence on the effect of exercise on leptin concentrations in health individuals published from 2000 to 20 September 2022, accordi

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Abdusalamova, A. I., O. A. Bettikher, K. A. Rudenko, O. A. Belyaeva, A. E. Neimark, and I. E. Zazerskaya. "Adipokinesand Ghrelin Rolein Regulation of Ovarian Function in Obesity." Obesity and metabolism 19, no. 3 (2022): 324–31. http://dx.doi.org/10.14341/omet12825.

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There is a great worldwide trend in the incidence of obesity, which is increasing with each passing year among all populations, including women of reproductive age. Given the impressive list of diseases associated with obesity, as well as the negative inverse correlation of the severity of obesity with fertility, this problem is global not only in the social sphere, but it also becomes demographically significant.Along with other pathogenetic mechanisms leading to persistent anovulation, an imbalance in adipokine production by adipose tissue can also serve as one of the important links in the

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Wei, Zhikui, You Chen, and Raghu P. Upender. "Sleep Disturbance and Metabolic Dysfunction: The Roles of Adipokines." International Journal of Molecular Sciences 23, no. 3 (2022): 1706. http://dx.doi.org/10.3390/ijms23031706.

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Adipokines are a growing group of peptide or protein hormones that play important roles in whole body metabolism and metabolic diseases. Sleep is an integral component of energy metabolism, and sleep disturbance has been implicated in a wide range of metabolic disorders. Accumulating evidence suggests that adipokines may play a role in mediating the close association between sleep disorders and systemic metabolic derangements. In this review, we briefly summarize a group of selected adipokines and their identified function in metabolism. Moreover, we provide a balanced overview of these adipok

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Wiecek, Magdalena, Mateusz Mardyla, Jadwiga Szymura, et al. "Maximal Intensity Exercise Induces Adipokine Secretion and Disrupts Prooxidant–Antioxidant Balance in Young Men with Different Body Composition." International Journal of Molecular Sciences 26, no. 1 (2025): 350. https://doi.org/10.3390/ijms26010350.

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Maximal physical effort induces a disturbance in the body’s energy homeostasis and causes oxidative stress. The aim of the study was to determine whether prooxidant–antioxidant balance disturbances and the secretion of adipokines regulating metabolism, induced by maximal intensity exercise, are dependent on body composition in young, healthy, non-obese individuals. We determined changes in the concentration of advanced protein oxidation products (AOPP), markers of oxidative damage to nucleic acids (DNA/RNA/ox), and lipid peroxidation (LPO); catalase (CAT), superoxide dismutase (SOD), and gluta

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Sanchez-Rebordelo, Estrella, Juan Cunarro, Sonia Perez-Sieira, et al. "Regulation of Chemerin and CMKLR1 Expression by Nutritional Status, Postnatal Development, and Gender." International Journal of Molecular Sciences 19, no. 10 (2018): 2905. http://dx.doi.org/10.3390/ijms19102905.

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Chemerin (also known as tazarotene-induced gene 2 and retinoic acid receptor responder 2) has been identified as an adipokine that exerts effects on many biological processes, including adipogenesis, angiogenesis, inflammation, immune responses, and food intake. This variety of effects has led to its implication in obesity and co-morbidities including diabetes and a risk of cardiovascular disease. The biological effects are mostly mediated by a so-called G protein-coupled receptor, chemokine-like receptor 1 (CMKLR1). Given the association of chemerin with obesity and related diseases, we decid

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Klöting, Nora, Mathias Fasshauer, Arne Dietrich, et al. "Insulin-sensitive obesity." American Journal of Physiology-Endocrinology and Metabolism 299, no. 3 (2010): E506—E515. http://dx.doi.org/10.1152/ajpendo.00586.2009.

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The association between obesity and impaired insulin sensitivity has long been recognized, although a subgroup of obese individuals seems to be protected from insulin resistance. In this study, we systematically studied differences in adipose tissue biology between insulin-sensitive (IS) and insulin-resistant (IR) individuals with morbid obesity. On the basis of glucose infusion rate during euglycemic hyperinsulinemic clamps, 60 individuals with a BMI of 45 ± 1.3 kg/m2 were divided into an IS and IR group matched for age, sex, and body fat prior to elective surgery. We measured fat distributio

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Ramanjaneya, Manjunath, Jing Chen, James E. Brown, et al. "Identification of Nesfatin-1 in Human and Murine Adipose Tissue: A Novel Depot-Specific Adipokine with Increased Levels in Obesity." Endocrinology 151, no. 7 (2010): 3169–80. http://dx.doi.org/10.1210/en.2009-1358.

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Nesfatin-1 is a recently identified anorexigenic peptide derived from its precursor protein, nonesterified fatty acid/nucleobindin 2 (NUCB2). Although the hypothalamus is pivotal for the maintenance of energy homeostasis, adipose tissue plays an important role in the integration of metabolic activity and energy balance by communicating with peripheral organs and the brain via adipokines. Currently no data exist on nesfatin-1 expression, regulation, and secretion in adipose tissue. We therefore investigated NUCB2/nesfatin-1 gene and protein expression in human and murine adipose tissue depots.

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Duliban, Michal, Ewelina Gorowska-Wojtowicz, Waclaw Tworzydlo, et al. "Interstitial Leydig Cell Tumorigenesis—Leptin and Adiponectin Signaling in Relation to Aromatase Expression in the Human Testis." International Journal of Molecular Sciences 21, no. 10 (2020): 3649. http://dx.doi.org/10.3390/ijms21103649.

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Although epidemiological studies from the last years report an increase in the incidences of Leydig cell tumors (previously thought to be a rare disease), the biochemical characteristics of that tumor important for understanding its etiology, diagnosis, and therapy still remains not completely characterized. Our prior studies reported G-protein coupled estrogen receptor signaling and estrogen level disturbances in Leydig cell tumors. In addition, we found that expressions of multi-level-acting lipid balance- and steroidogenesis–controlling proteins including peroxisome proliferator-activated r

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Rodrigues, Débora Fernandes, Milene Cristina do Carmo Henriques, Marina Chaves Oliveira, et al. "Acute intake of a high-fructose diet alters the balance of adipokine concentrations and induces neutrophil influx in the liver." Journal of Nutritional Biochemistry 25, no. 4 (2014): 388–94. http://dx.doi.org/10.1016/j.jnutbio.2013.11.012.

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Stofkova, Andrea, Blanka Zelezna, Marianna Romzova, et al. "Effect of Feeding Status on Adjuvant Arthritis Severity, Cachexia, and Insulin Sensitivity in Male Lewis Rats." Mediators of Inflammation 2010 (2010): 1–12. http://dx.doi.org/10.1155/2010/398026.

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We studied the effect of food restriction, overfeeding, and normofeeding on cachexia, inflammatory and metabolic parameters, and insulin sensitivity in chronic adjuvant arthritis (AA) in rats. Food restriction during AA increased circulating ghrelin, corticosterone, decreased leptin, and ameliorated arthrogram score and systemic inflammation compared to normofeeding. Overfeeding worsened arthrogram score and systemic inflammation, and led to lipid accumulation in the liver, but not to alterations of adipokine and ghrelin plasma levels relative to normofeeding. Independently of feeding status,

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Özkan, Elife. "The Relationship of Leptin Levels with Lipid Profile and Cardiovascular Disease Risk Factors in Obese Individuals." Genel Tıp Dergisi 35, no. 3 (2025): 500–511. https://doi.org/10.54005/geneltip.1641965.

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Aims: This study was conducted as a systematic literature review to evaluate the effects of leptin hormone on lipid profile and cardiovascular disease (CVD) risk factors in obese individuals. Leptin is an adipokine playing a key role in energy balance and metabolic processes, and its serum levels are significantly increased in obesity. The hypothesis that increased leptin levels may negatively affect cardiovascular risk factors by contributing to dyslipidemia was investigated. Methods: PubMed, Scopus, and Web of Science databases were searched for studies published between January 2010 and Oct

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Chiang, Dian J., Michele T. Pritchard, and Laura E. Nagy. "Obesity, diabetes mellitus, and liver fibrosis." American Journal of Physiology-Gastrointestinal and Liver Physiology 300, no. 5 (2011): G697—G702. http://dx.doi.org/10.1152/ajpgi.00426.2010.

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Obesity is a global epidemic with more than 1 billion overweight adults and at least 300 million obese patients worldwide. Diabetes is characterized by a defect in insulin secretion or a decrease in sensitivity to insulin, which results in elevated fasting blood glucose. Both obesity and elevated fasting glucose are risk factors for nonalcoholic fatty liver disease, a disease spectrum that includes hepatic steatosis (nonalcoholic fatty liver), nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Increased adiposity and insulin resistance contribute to the progression from NASH to fibr

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Parasiliti-Caprino, Mirko, Martina Bollati, Fabio Dario Merlo, Ezio Ghigo, Mauro Maccario, and Simona Bo. "Adipose Tissue Dysfunction in Obesity: Role of Mineralocorticoid Receptor." Nutrients 14, no. 22 (2022): 4735. http://dx.doi.org/10.3390/nu14224735.

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The mineralocorticoid receptor (MR) acts as an essential regulator of blood pressure, volume status, and electrolyte balance. However, in recent decades, a growing body of evidence has suggested that MR may also have a role in mediating pro-inflammatory, pro-oxidative, and pro-fibrotic changes in several target organs, including the adipose tissue. The finding that MR is overexpressed in the adipose tissue of patients with obesity has led to the hypothesis that this receptor can contribute to adipokine dysregulation and low-grade chronic inflammation, alterations that are linked to the develop

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Smith, P. M., A. P. Chambers, C. J. Price, et al. "The subfornical organ: a central nervous system site for actions of circulating leptin." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 296, no. 3 (2009): R512—R520. http://dx.doi.org/10.1152/ajpregu.90858.2008.

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Adipose tissue plays a critical role in energy homeostasis, secreting adipokines that control feeding, thermogenesis, and neuroendocrine function. Leptin is the prototypic adipokine that acts centrally to signal long-term energy balance. While hypothalamic and brain stem nuclei are well-established sites of action of leptin, we tested the hypothesis that leptin signaling occurs in the subfornical organ (SFO). The SFO is a circumventricular organ (CVO) that lacks the normal blood-brain barrier, is an important site in central autonomic regulation, and has been suggested to have a role in modula

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Mohammadi, Iman, Masoud Sadeghi, Golnaz Tajmiri, Annette Beatrix Brühl, Laleh Sadeghi Bahmani, and Serge Brand. "Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis." Life 13, no. 1 (2023): 245. http://dx.doi.org/10.3390/life13010245.

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Background and objective: Obstructive sleep apnea (OSA) can be related to changes in the levels of adipokines and neuropeptides, which in turn may affect the energy balance components of neuronal cells. Herein, a systematic review and meta-analysis checked the changes in serum/plasma levels of omentin-1 (OM-1: an adipokine) and orexin-A (OXA: a neuropeptide) in adults (age > 18 years old) with OSA (aOSA) compared to controls. Materials and methods: Four databases (Cochrane Library, PubMed, Web of Science, and Scopus) were systematically searched until 14 November 2022, without any restricti

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Trayhurn, Paul, and I. Stuart Wood. "Adipokines: inflammation and the pleiotropic role of white adipose tissue." British Journal of Nutrition 92, no. 3 (2004): 347–55. http://dx.doi.org/10.1079/bjn20041213.

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White adipose tissue is now recognised to be a multifunctional organ; in addition to the central role of lipid storage, it has a major endocrine function secreting several hormones, notably leptin and adiponectin, and a diverse range of other protein factors. These various protein signals have been given the collective name ‘adipocytokines’ or ‘adipokines’. However, since most are neither ‘cytokines’ nor ‘cytokine-like’, it is recommended that the term ‘adipokine’ be universally adopted to describe a protein that is secreted from (and synthesised by) adipocytes. It is suggested that the term i

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Dixit, Vishwa. "IMMUNOMETABOLIC CHECKPOINTS OF INFLAMMAGING." Innovation in Aging 7, Supplement_1 (2023): 140. http://dx.doi.org/10.1093/geroni/igad104.0458.

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Abstract Inflammation is a key hallmark and driver of age-related functional decline. Evidence that innate immune sensor NLRP3 inflammasome links aging to functional decline supports Metchnikoff’s original prediction that phagocytes or macrophages drive aging-associated degenerative diseases in an organism. Tissue resident macrophages are key to maintenance of homeostasis, a response that is compromised with age. It remains unclear whether negative energy balance in a host elicited by caloric restriction (CR) impacts mechanisms that control inflammation. The precise identity of factor(s) that

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Will, Katja, Judith Kuzinski, Marie-France Palin, Jan-Peter Hildebrandt, and Charlotte Rehfeldt. "A second look at leptin and adiponectin actions on the growth of primary porcine myoblasts under serum-free conditions." Archives Animal Breeding 57, no. 1 (2014): 1–10. http://dx.doi.org/10.7482/0003-9438-57-029.

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Abstract. Cross-talk between adipose tissue and skeletal muscle may be mediated in part by adipokines. This study was conducted to elucidate further aspects of a possible role of recombinant adiponectin and leptin in the in vitro growth of primary porcine skeletal muscle cells cultured in energetically balanced, growth factor-supplemented, serum-free medium (GF-SFM). Therefore, the effects of these adipokines on cell number (DNA content), DNA synthesis rate, cell death and on key intracellular signalling molecules were investigated. Short-term adiponectin and leptin treatment decreased DNA syn

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Shilpa, Akula, and Jammula Surya Prasanna. "A comparative evaluation of adipokine VASPIN in female obese and non-obese subjects with periodontitis and health." Journal of Oral Research and Review 16, no. 1 (2024): 21–27. http://dx.doi.org/10.4103/jorr.jorr_34_23.

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Abstract Introduction: Periodontitis and obesity are major health hazards. Adiposity stimulates cytokines which aggravate periodontitis. To balance this body secretes an anti-inflammatory adipokine-like visceral adipose tissue-derived serine protease inhibitor (VASPIN). Aims and Objectives: The study aimed to assess serum VASPIN levels in females with and without periodontitis, categorized by obesity status. Materials and Methods: Eighty female subjects with the age range of 35–44 years were included in this observational study. All have been categorized into four groups, 20 in each group. The

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Benaitreau, Delphine, Esther Dos Santos, Marie-Christine Leneveu, et al. "Effects of adiponectin on human trophoblast invasion." Journal of Endocrinology 207, no. 1 (2010): 45–53. http://dx.doi.org/10.1677/joe-10-0170.

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Adiponectin is an adipokine with insulin-sensitizing, anti-inflammatory, anti-atherogenic, and anti-proliferative effects. The expression of specific adiponectin receptors in the placenta and in the endometrium suggests a role for this cytokine in placental development, but this role has not yet been elucidated. The invasion of trophoblast cells during the first trimester of pregnancy being crucial to placentation process, we have studied adiponectin effects on human trophoblast invasive capacities. We found that adiponectin stimulated human trophoblast cell migration in HTR-8/SVneo cells in a

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Hang, Hardy, Jennifer Bailey, and Carrie Elks. "Oncostatin M Mediates Adipocyte Expression and Secretion of Stromal-Derived Factor 1." Biology 8, no. 1 (2019): 19. http://dx.doi.org/10.3390/biology8010019.

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Adipose tissue homeostasis depends on interactions between stromal cells, adipocytes, and the cytokines and chemokines they produce. The gp130 cytokine, oncostatin M (OSM), plays a role in adipose tissue homeostasis. Mice, lacking the OSM receptor (OSMR) in adipocytes (OsmrFKO mice), exhibit derangements in adipose tissue, insulin sensitivity, and immune cell balance. Here, we describe a possible role for the chemokine stromal-derived factor 1 (SDF-1) in these alterations. We treated 3T3-L1 adipocytes with OSM and observed a suppression of SDF-1 gene expression and protein secretion, an effect

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Ordoñez, Marta, Natalia Presa, Miguel Trueba, and Antonio Gomez-Muñoz. "Implication of Ceramide Kinase in Adipogenesis." Mediators of Inflammation 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/9374563.

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Ceramide kinase (CerK) plays a critical role in the regulation of cell growth and survival and has been implicated in proinflammatory responses. In this work, we demonstrate that CerK regulates adipocyte differentiation, a process associated with obesity, which causes chronic low-grade inflammation. CerK was upregulated during differentiation of 3T3-L1 preadipocytes into mature adipocytes. Noteworthy, knockdown of CerK using specific siRNA to silence the gene encoding this kinase resulted in substantial decrease of lipid droplet formation and potent depletion in the content of triacylglycerols

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Man, Andy W. C., Yawen Zhou, Ning Xia, and Huige Li. "Perivascular Adipose Tissue Oxidative Stress in Obesity." Antioxidants 12, no. 8 (2023): 1595. http://dx.doi.org/10.3390/antiox12081595.

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Perivascular adipose tissue (PVAT) adheres to most systemic blood vessels in the body. Healthy PVAT exerts anticontractile effects on blood vessels and further protects against cardiovascular and metabolic diseases. Healthy PVAT regulates vascular homeostasis via secreting an array of adipokine, hormones, and growth factors. Normally, homeostatic reactive oxygen species (ROS) in PVAT act as secondary messengers in various signalling pathways and contribute to vascular tone regulation. Excessive ROS are eliminated by the antioxidant defence system in PVAT. Oxidative stress occurs when the produ

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Catana, Oana Maria, Alexandra Floriana Nemes, Ramona Cioboata, et al. "Leptin and Insulin in COPD: Unveiling the Metabolic-Inflammatory Axis—A Narrative Review." Journal of Clinical Medicine 14, no. 8 (2025): 2611. https://doi.org/10.3390/jcm14082611.

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Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating condition characterized by airflow limitations and systemic inflammation. The interaction between the metabolic and inflammatory pathways plays a key role in disease progression, with leptin and insulin emerging as pivotal metabolic regulators. Leptin, an adipokine that regulates energy homeostasis, and insulin, the primary regulator of glucose metabolism, are both altered in COPD patients. This narrative review provides an in-depth examination of the roles of leptin and insulin in COPD pathogenesis, focusing on the

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Li, Yun, Qiong-Hong Xie, Huai-Zhou You, et al. "Twelve Weeks of Pioglitazone Therapy Significantly Attenuates Dysmetabolism and Reduces Inflammation in Continuous Ambulatory Peritoneal Dialysis Patients—A Randomized Crossover Trial." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 32, no. 5 (2012): 507–15. http://dx.doi.org/10.3747/pdi.2011.00116.

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BackgroundThe aim of the present study was to investigate the effect of oral pioglitazone (PIO) on lipid metabolism, insulin resistance, inflammation, and adipokine metabolism in continuous ambulatory peritoneal dialysis (CAPD) patients.MethodsIn this randomized crossover trial, 36 CAPD patients with serum triglyceride levels above 1.8 mmol/L were randomly assigned to receive either oral PIO 15 mg once daily or no PIO for 12 weeks. Then, after a 4-week washout, the patients were switched to the alternative regimen. The primary endpoint was change in serum triglycerides during the PIO regimen c

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Okuliarova, Monika, Valentina Sophia Rumanova, Katarina Stebelova, and Michal Zeman. "Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism." International Journal of Molecular Sciences 21, no. 18 (2020): 6919. http://dx.doi.org/10.3390/ijms21186919.

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Dim light at night (dLAN) is associated with metabolic risk but the specific effects on lipid metabolism have only been evaluated to a limited extent. Therefore, to explore whether dLAN can compromise lipid metabolic homeostasis in healthy individuals, we exposed Wistar rats to dLAN (~2 lx) for 2 and 5 weeks and analyzed the main lipogenic pathways in the liver and epididymal fat pad, including the control mechanisms at the hormonal and molecular level. We found that dLAN promoted hepatic triacylglycerol accumulation, upregulated hepatic genes involved in de novo synthesis of fatty acids, and

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Otelea, Marina Ruxandra, Oana Cristina Arghir, Corina Zugravu, and Agripina Rascu. "Adiponectin and Asthma: Knowns, Unknowns and Controversies." International Journal of Molecular Sciences 22, no. 16 (2021): 8971. http://dx.doi.org/10.3390/ijms22168971.

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Adiponectin is an adipokine associated with the healthy obese phenotype. Adiponectin increases insulin sensitivity and has cardio and vascular protection actions. Studies related to adiponectin, a modulator of the innate and acquired immunity response, have suggested a role of this molecule in asthma. Studies based on various asthma animal models and on the key cells involved in the allergic response have provided important insights about this relation. Some of them indicated protection and others reversed the balance towards negative effects. Many of them described the cellular pathways activ

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Wawrzkiewicz-Jałowiecka, Agata, Anna Lalik, and Graça Soveral. "Recent Update on the Molecular Mechanisms of Gonadal Steroids Action in Adipose Tissue." International Journal of Molecular Sciences 22, no. 10 (2021): 5226. http://dx.doi.org/10.3390/ijms22105226.

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The gonadal steroids, including androgens, estrogens and progestogens, are involved in the control of body fat distribution in humans. Nevertheless, not only the size and localization of the fat depots depend on the sex steroids levels, but they can also highly affect the functioning of adipose tissue. Namely, the gonadocorticoids can directly influence insulin signaling, lipid metabolism, fatty acid uptake and adipokine production. They may also alter energy balance and glucose homeostasis in adipocytes in an indirect way, e.g., by changing the expression level of aquaglyceroporins. This work

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O'Carroll, Anne-Marie, Stephen J. Lolait, Louise E. Harris, and George R. Pope. "The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis." Journal of Endocrinology 219, no. 1 (2013): R13—R35. http://dx.doi.org/10.1530/joe-13-0227.

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The apelin receptor (APJ; gene symbolAPLNR) is a member of the G protein-coupled receptor gene family. Neural gene expression patterns of APJ, and its cognate ligand apelin, in the brain implicate the apelinergic system in the regulation of a number of physiological processes. APJ and apelin are highly expressed in the hypothalamo–neurohypophysial system, which regulates fluid homeostasis, in the hypothalamic–pituitary–adrenal axis, which controls the neuroendocrine response to stress, and in the forebrain and lower brainstem regions, which are involved in cardiovascular function. Recently, ap

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