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Journal articles on the topic 'Adiponectin/leptin'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Zhao, Shangang, Christine M. Kusminski, and Philipp E. Scherer. "Adiponectin, Leptin and Cardiovascular Disorders." Circulation Research 128, no. 1 (2021): 136–49. http://dx.doi.org/10.1161/circresaha.120.314458.

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The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a sophisticated and highly active endocrine organ, opening a new era of investigating adipose-mediated tissue crosstalk. Both obesity-associated hyperleptinemia and hypoadiponectinemia are important biomarkers to predict cardiovascular outcomes, suggesting a crucial role for adiponectin and leptin in obesity-associated cardiovascular disorders. Normal physiological levels of adiponectin and leptin are indeed essential to maintain proper cardiovascular function. Insufficient adiponectin and leptin signaling

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Bocian-Jastrzębska, Agnes, Anna Malczewska-Herman, Violetta Rosiek, and Beata Kos-Kudła. "Assessment of the Role of Leptin and Adiponectinas Biomarkers in Pancreatic Neuroendocrine Neoplasms." Cancers 15, no. 13 (2023): 3517. http://dx.doi.org/10.3390/cancers15133517.

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Data on the possible connection between circulating adipokines and PanNENs are limited. This novel study aimed to assess the serum levels of leptin and adiponectin and their ratio in patients with PanNENs and to evaluate the possible relationship between them and PanNEN’s grade or stage, including the presence of metastases. The study group consisted of PanNENs (n = 83), and healthy controls (n = 39). Leptin and adiponectin measurement by an ELISA assay was undertaken in the entire cohort. The serum concentration of adiponectin was significantly higher in the control group compared to the stud

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Jardé, T., F. Caldefie-Chézet, N. Goncalves-Mendes, et al. "Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies." Endocrine-Related Cancer 16, no. 4 (2009): 1197–210. http://dx.doi.org/10.1677/erc-09-0043.

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Obesity is a risk factor for breast cancer development. A recent hypothesis suggests that the adipokines, adiponectin and leptin, are involved in breast cancer development. This prompted us to investigate the role of adiponectin and leptin in mammary carcinogenesis. Adiponectin receptors (AdipoR1 and AdipoR2) and leptin receptor (Ob-Rt, representing all the isoforms of Ob-R) proteins were detected by immunohistochemistry in in situ ductal carcinoma, invasive ductal malignancy, and healthy adjacent tissue. In addition, mRNA expression of adiponectin, AdipoR1, AdipoR2, leptin, Ob-Rt, and Ob-Rl (

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Mi, Jie, Mercedes Nancy Munkonda, Ming Li, et al. "Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents." Journal of Obesity 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/892081.

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Objective. To evaluate leptin and adiponectin as biomarkers of metabolic syndrome (MS) risk factors even in nonobese children/adolescents.Methods. Serum leptin, adiponectin, leptin:adiponectin ratio, lipids, glucose, and insulin concentrations as well as body size parameters and pubertal development were evaluated in a large population of Chinese children/adolescents (n=3505, 6–18 years, 1722 girls and 1783 boys).Results. Leptin concentration increased while adiponectin decreased with obesity, both were influenced by pubertal development. Central obesity had an additive effect on leptin levels

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K, Selthofer-Relatić, Radić R, Stupin A, et al. "Leptin/adiponectin ratio in overweight patients – gender differences." Diabetes and Vascular Disease Research 15, no. 3 (2018): 260–62. http://dx.doi.org/10.1177/1479164117752491.

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Objective: Obesity-related atherosclerosis is a systemic disease with a background connected to multiple metabolic-neurohumoral pathways. The leptin/adiponectin ratio has been suggested as an atherosclerotic marker in obese patients. The aim of this study was to assess (1) the significance of the L/A ratio in overweight subjects, (2) the relation with anthropometric/metabolic parameters and (3) gender difference. Method: The study included 80 adult males and females, overweight, non-diabetic patients. Biochemical blood analysis and anthropometric and cardiovascular measurements were performed.

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Ambarwati, Ria, Damai Santosa, Eko Adhi Pangarsa, et al. "High Leptin and Low Adiponectin Levels in The Metabolic Syndrome Patients with Malignancy." Indonesian Biomedical Journal 15, no. 5 (2023): 297–303. http://dx.doi.org/10.18585/inabj.v15i5.2567.

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BACKGROUND: Metabolic syndrome (MetS), which is characterized by insulin resistance, adipocyte accumulation, and obesity, has been linked to malignancy development. Both leptin, an adipose tissue-produced cytokine-like hormone, and adiponectin, a hormone secreted by adipose tissue, play roles in the progression of MetS. However, the presence of leptin and adiponectin is also assumed to be associated with cancer proliferation. Therefore, it is necessary to investigate the profile of leptin and adiponectin levels in MetS patients with malignancy and non-malignancy.METHODS: This was a cross-secti

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Mednova, Irina A., Anastasiia S. Boiko, Elena G. Kornetova, et al. "Adipocytokines and Metabolic Syndrome in Patients with Schizophrenia." Metabolites 10, no. 10 (2020): 410. http://dx.doi.org/10.3390/metabo10100410.

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The adipokines leptin, adiponectin, tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) might be associated with metabolic syndrome (MetS) in patients with schizophrenia. In the present study, we attempted to confirm the results of previous reports and assessed their MetS-related correlation with body fat composition and biochemical parameters. We measured in 46 patients with schizophrenia and MetS serum levels of adiponectin insulin, leptin, TNF-α and IL-6 and compared these levels to those of patients with schizophrenia without MetS. The MetS patients had significantly increased le

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Vega, Gloria Lena, and Scott M. Grundy. "Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio." Journal of Obesity 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/409679.

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Background. High adiponectin/leptin ratio may be protective from metabolic risks imparted by high triglyceride, low HDL, and insulin resistance.Methods. This cross-sectional study examines plasma adipokine levels in 428 adult men who were subgrouped according to low (<6.5 μg/mL)and high (≥6.5 μg/mL)adiponectin levels or a low or high ratio of adiponectin/leptin.Results. Men with high adiponectin/leptin ratio had lower plasma triglyceride and higher HDL cholesterol than those with low ratio. Similarly, those with high adiponectin/leptin ratio had lower TG/HDL cholesterol ratio and HOMA2-IR t

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Tonelli, Adriano R., Wassim H. Fares, Wael Dakkak, Youlan Rao, Xuan Zhou, and Raed A. Dweik. "Do single or sequential measurements of leptin and adiponectin in plasma have prognostic value in pulmonary arterial hypertension?" Pulmonary Circulation 7, no. 3 (2017): 727–29. http://dx.doi.org/10.1177/2045893217717219.

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Leptin (a neuroendocrine peptide that enhances metabolism and acts on the hypothalamus to suppress appetite) and adiponectin (a protein that has insulin-sensitizing, anti-inflammatory, and antiproliferative properties) are involved in the pathobiology of pulmonary arterial hypertension (PAH). We hypothesized that plasma leptin and adiponectin as well as the leptin/adiponectin ratio are abnormal in PAH patients and their levels track with disease severity and functional changes during follow-up. We tested this hypothesis in a cohort of patients included in the 16-week, international, multicente

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Matovic, Sara, Christoph Rummel, Elena Neumann, Jennifer McGrath, and Jean-Philippe Gouin. "Adverse Childhood Experiences Influence Longitudinal Changes in Leptin But Not Adiponectin." Biopsychosocial Science and Medicine 87, no. 2 (2025): 118–28. https://doi.org/10.1097/psy.0000000000001366.

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Objective Adverse childhood experiences (ACEs) are associated with a greater risk of obesity and cardiometabolic disease. Adipokines, including leptin and adiponectin, play vital roles in biological processes linked to obesity and cardiometabolic risk. The adiponectin/leptin ratio may represent a marker of impaired hormonal regulation of adipose tissue. Prior cross-sectional studies suggest patterns of higher plasma leptin and lower adiponectin among adults who have experienced ACEs. This study addresses whether ACEs influence longitudinal changes in leptin, adiponectin, and the adiponectin/le

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Mirza, Shaper, Hui-Qi Qu, Quan Li, et al. "Adiponectin/leptin ratio and Metabolic Syndrome in a Mexican American population." Clinical & Investigative Medicine 34, no. 5 (2011): 290. http://dx.doi.org/10.25011/cim.v34i5.15672.

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Objective: Adiponectin and leptin play critical roles in the development of Metabolic Syndrome (MetS). This study was designed to assess the feasibility of using circulating levels of adiponectin and leptin for the early diagnosis of MetS. Methods: A cross-sectional study was performed using data from 367 participants randomly selected from a well-characterized cohort of Mexican-Americans living at the US-Mexico border. Results: Significant differences in circulating levels of adiponectin and leptin were observed between males and females. Adiponectin/leptin correlated significantly with MetS

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Salimi, Saeedeh, Farzaneh Farajian-Mashhadi, Anoosh Naghavi, et al. "Different Profile of Serum Leptin between Early Onset and Late Onset Preeclampsia." Disease Markers 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/628476.

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Aim. This study was designed to clarify the role of leptin and adiponectin in preeclampsia (PE) pathogenesis and different subtypes of preeclampsia.Method. This case control study was performed in 45 PE patients and 45 healthy controls matched for age, BMI, and ethnicity. Serum leptin and adiponectin levels were determined by enzyme linked immunosorbent assay (ELISA).Results. Maternal serum leptin and adiponectin were significantly higher in PE women than controls. Serum leptin was elevated in early onset preeclampsia (EOPE) and late onset preeclampsia (LOPE) compared to controls. Among PE pat

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Ali Talat, Muhammad, Muhammad Shoaib, Sana Sabir, et al. "Determination of Leptin Adiponectin, LDL/HDL ratio with substantial role of Adiponectin and its Receptor." Pakistan Journal of Medical and Health Sciences 15, no. 10 (2021): 2550–53. http://dx.doi.org/10.53350/pjmhs2115102550.

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Aim: To determine Leptin/Adiponectin ratio, LDL/HDL ratio and AdipoR1 in obese and healthy subjects along with their respective lipid status. Methods: This cross-sectional comparative study was conducted in Sialkot city. One hundred and thirty-two participants took part in this research. Participants were equally divided into two groups containing non-obese and obese subjects. Mean age was 39.6±0.97 years. Mean BMI for obese subjects was 31.55±0.6 while non-obese group BMI was 20.5±0.2. Individuals with conditions and history of drugs were excluded. Informed and written consent was obtained pr

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Liu, Pi-Hua, Yi-Der Jiang, Wei J. Chen, et al. "Genetic and Environmental Influences on Adiponectin, Leptin, and BMI Among Adolescents in Taiwan: A Multivariate Twin/Sibling Analysis." Twin Research and Human Genetics 11, no. 5 (2008): 495–504. http://dx.doi.org/10.1375/twin.11.5.495.

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AbstractCirculating levels of leptin and adiponectin are closely associated with obesity. However, it is not known whether there are common shared genes or environment exerting influences on the levels of leptin, adiponectin, and BMI. We aimed to assess the relative contribution of genes and environment to adiponectin, leptin, and BMI individually as well as simultaneously to the three measures. Our subjects included a total of 228 twin/sibling pairs aged 12 to 18 (130 monozygotic twins, 68 dizygotic twins and 30 sibling pairs) were recruited from the middle schools. Multivariate analyses were

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Zheng, Jia, Xinhua Xiao, Qian Zhang, et al. "Correlation of High-Molecular-Weight Adiponectin and Leptin Concentrations with Anthropometric Parameters and Insulin Sensitivity in Newborns." International Journal of Endocrinology 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/435376.

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Objective. High-molecular-weight adiponectin (HMW-adiponectin) and leptin are two important adipokines. The aim of this study was to examine the association between the two adipokines and anthropometric measurements of neonates at birth. Furthermore, we would like to explore whether HMW-adiponectin and leptin correlate with insulin sensitivity in neonates.Methods. Venous cord blood samples were obtained from 266 full-term healthy neonates consecutively born at Peking Union Medical College Hospital. HMW-adiponectin, leptin, blood glucose, and insulin concentrations were measured.Results. HMW-ad

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Khosrowbeygi, A., and H. Ahmadvand. "Leptin to adiponectin ratio in preeclampsia." Bangladesh Medical Research Council Bulletin 39, no. 1 (2013): 18–21. http://dx.doi.org/10.3329/bmrcb.v39i1.15805.

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The aim of the present study was to assess leptin/adiponectin ratio in preeclamptic patients compared with normal pregnant women. A cross-sectional study was designed. The study population consisted of 30 preeclamptic patients and 30 healthy pregnant women. Serum levels of total leptin and adiponectin were assessed using commercially available enzyme-linked immunosorbent assay methods. The oneway ANOVA and Students t tests and Pearsons correlation analysis were used for statistical calculations. Levels of leptin and adiponectin were also adjusted for BMI. A p-value <0.05 was considered st

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Lederer, Ann-Kathrin, Maximilian Andreas Storz, Roman Huber, Luciana Hannibal, and Elena Neumann. "Plasma Leptin and Adiponectin after a 4-Week Vegan Diet: A Randomized-Controlled Pilot Trial in Healthy Participants." International Journal of Environmental Research and Public Health 19, no. 18 (2022): 11370. http://dx.doi.org/10.3390/ijerph191811370.

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Adiponectin and leptin are important mediators of metabolic homeostasis. The actions of these adipokines extend beyond adipocytes and include systemic modulation of lipid and glucose metabolism, nutrient flux, and the immune response to changes in nutrition. Herein, we hypothesized that short-term intervention with a vegan diet might result in an improvement of plasma concentrations of adiponectin and leptin and the leptin/adiponectin ratio. We investigated the response of plasma adiponectin and leptin to a 4-week intervention with a vegan or meat-rich diet and its associations with sex, BMI a

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Akyol, Murat, Leyla Demir, Ahmet Alacacioglu, et al. "The Effects of Adjuvant Endocrine Treatment on Serum Leptin, Serum Adiponectin and Body Composition in Patients with Breast Cancer: The Izmir Oncology Group (IZOG) Study." Chemotherapy 61, no. 2 (2015): 57–64. http://dx.doi.org/10.1159/000440944.

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Background: A limited number of studies have been conducted on the effects of hormonal therapy with tamoxifen (TMX) or aromatase inhibitors (AIs) on plasma levels of leptin and adiponectin, as well as body composition in breast cancer (BC) patients. Therefore, we aimed to analyze the relationship between adipocytokines and body composition as well as the effects of TMX and AIs on plasma adiponectin, leptin, leptin/adiponectin ratio (LAR) and body composition. Methods: Patients were treated with either TMX or AI according to their menopausal status after adjuvant radiotherapy. Changes in body c

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Dyck, David J. "Leptin and Adiponectin." Medicine & Science in Sports & Exercise 37, Supplement (2005): S416. http://dx.doi.org/10.1249/00005768-200505001-02161.

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Dyck, David J. "Leptin and Adiponectin." Medicine & Science in Sports & Exercise 37, Supplement (2005): S416. http://dx.doi.org/10.1097/00005768-200505001-02161.

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Handy, Jeffrey A., Ping P. Fu, Pradeep Kumar, et al. "Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis." Biochemical Journal 440, no. 3 (2011): 385–95. http://dx.doi.org/10.1042/bj20102148.

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Adiponectin is protective against hepatic fibrosis, whereas leptin promotes fibrosis. In HSCs (hepatic stellate cells), leptin signals via a JAK2 (Janus kinase 2)/STAT3 (signal transducer and activator of transcription 3) pathway, producing effects that enhance ECM (extracellular matrix) deposition. SOCS-3 (suppressor of cytokine signalling-3) and PTP1B (protein tyrosine phosphatase 1B) are both negative regulators of JAK/STAT signalling, and recent studies have demonstrated a role for adiponectin in regulating SOCS-3 expression. In the present study we investigate mechanisms whereby adiponect

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Piyali, Das, Biswas Subhradev, Kumar Bandyopadhyay Subir, Manna Madhumita, and Bhattacharya Gorachand. "CORRELATION OF ADIPOCYTOKINES AND OXIDATIVE STRESS IN TYPE 2 DIABETES MELLITUS AND THEIR ASSOCIATION WITH DEGREE OF INSULIN RESISTANCE." International Journal Of Basic And Applied Physiology 5, no. 1 (2016): 35–39. https://doi.org/10.5281/zenodo.4480802.

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<strong>Background and Objectives:</strong> Adipocytokines and Oxidative Stress are often studied in relation to various morbidities but whether these two are interrelated in causing insulin resistance in type 2 diabetes mellitus, is controversial. This study explored their association in type 2 diabetes mellitus and correlation with insulin resistance. <strong>Methods</strong>: 69 male diabetics and 30 age-sex matched non- diabetic control were studied. Fasting blood glucose, serum insulin, leptin, adiponectin and plasma MDA ( Malondealdehyde, marker for Oxidative Stress) were estimated and c

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Shawar, Reem, Heba E. Ayash, Maurice Puyua, and Fida Bacha. "PMON307 Adipokines and Bone Health in Hispanic Children." Journal of the Endocrine Society 6, Supplement_1 (2022): A622—A623. http://dx.doi.org/10.1210/jendso/bvac150.1291.

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Abstract Introduction Leptin and adiponectin are adipocytokines with important metabolic functions. Leptin to adiponectin ratio is a marker of adipose tissue dysfunction and is associated with insulin resistance and cardiometabolic risk. We previously reported a negative effect of adiposity on bone health. We examined the relationship of adipokines to bone mass in a large cohort of Hispanic youth. We hypothesized that adipocytokine dysregulation in childhood may contribute to adverse bone health in children with obesity. Methods We studied 501 (237 males and 264 females) children and adolescen

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Coimbra, Susana, Jorge Brandão Proença, Alice Santos-Silva, and Maria João Neuparth. "Adiponectin, Leptin, and Chemerin in Elderly Patients with Type 2 Diabetes Mellitus: A Close Linkage with Obesity and Length of the Disease." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/701915.

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Obesity, insulin resistance, and aging are closely associated and adipokines seem to have a crucial role in their pathophysiology. We aim to study the relationship between aging and chemerin, adiponectin, and leptin levels in type 2 diabetes mellitus (T2DM). Age correlated positively with chemerin and leptin and inversely with adiponectin. Body mass index (BMI) correlated positively with leptin (in males) and chemerin and inversely with adiponectin. The patients with ≥65 years(n=34)showed significantly higher leptin and chemerin and lower adiponectin levels than middle-aged (38–64 years) patie

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Ullah, Zia, Farukh Bashir, Kalsum Fatima, Shoaib Ahmed, Bakhtiar Hassan Tahir, and Faiza Irshad. "Changes in Serum Adiponectin and Serum Leptin Levels Can Predict Pre-Eclampsia in Pregnant Women: A Prospective Study." Pakistan Journal of Medical and Health Sciences 16, no. 12 (2022): 610–13. http://dx.doi.org/10.53350/pjmhs20221612610.

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Background: The study aims to investigate maternal adiponectin and leptin levels as prospective markers of preeclampsia, as well as the ratio of maternal adiponectin to leptin levels. Additionally, this research investigated the relationship between these two hormones. In addition to that, the purpose of this study was to analyze the connection that exists between the two hormones. Materials and Methods: This is a study that looks forward into the foreseeable future. The pregnant women who were willing to take part in the research were split into two groups: the first group, which was referred

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Kashif Nisar, Muhammad, Erum Afaq, Humera Afaq, Anila Jaleel, and Adnan Zuberi. "Leptin to Adiponectin ratio as Atherogenic Index in Ischemic Heart Disease Patients." Journal of Islamabad Medical & Dental College 7, no. 4 (2019): 285–90. http://dx.doi.org/10.35787/jimdc.v7i4.265.

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Objective: To determine plasma adiponectin and leptin levels in subjects with and without ischemic heart disease (IHD) and to find the correlation between leptin, adiponectin to the number of coronary vessels disease-using angiography.Patients and Methods: This is a cross-sectional study conducted Ziauddin University. 80 subjects were recruited who were undergoing angiography. Height, weight, Waist and hip circumference were measured. BMI and WHR were calculated accordingly. Venous blood was drawn to measure adiponectin and leptin using ELISA.Results: Leptin to adiponectin ratio (LA ratio) was

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Abdul Wahab, Atqah, Muna M. Maarafiya, Ashraf Soliman, Noura B. M. Younes, and Prem Chandra. "Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control." Journal of Allergy 2013 (December 17, 2013): 1–6. http://dx.doi.org/10.1155/2013/654104.

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There is growing evidence of a positive correlation between asthma and obesity in children and adults. Leptin and adiponectin regulate several metabolic and inflammatory functions. This study aims to evaluate serum leptin and adiponectin concentrations in asthmatic school children to investigate their association with obesity and the degree of asthma control. Obese asthmatic (OA) and nonobese asthmatic (NOA) children, aged 7 to 14, were randomly enrolled in this prospective study. Data on demographic, anthropometric, serum lipids, and spirometric measures and allergy status were collected and

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Kampmann, Freja B., Anne Cathrine B. Thuesen, Line Hjort, et al. "Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes." European Journal of Endocrinology 181, no. 6 (2019): 691–700. http://dx.doi.org/10.1530/eje-19-0658.

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Objective Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponectin, and FGF21 concentrations and their associations with measures of adiposity and metabolic traits during childhood/adolescence. Design and methods The follow-up study included 504 GDM and 540 control offspring aged 9–16 from the Danish National Birth Cohort. Anthropometric measu

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Zhang, Zhi, Fang Wang, Bing-jian Wang, et al. "Inhibition of leptin-induced vascular extracellular matrix remodelling by adiponectin." Journal of Molecular Endocrinology 53, no. 2 (2014): 145–54. http://dx.doi.org/10.1530/jme-14-0027.

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Vascular extracellular matrix (ECM) remodelling, which is the result of disruption in the balance of ECM synthesis and degradation, induces vessel fibrosis and thereby leads to hypertension. Leptin is known to promote tissue fibrosis, while adiponectin has recently been demonstrated to be anti-fibrogenic in tissue fibrosis. In this study, we aimed to evaluate the leptin-antagonist function of adiponectin and to further elucidate the mechanisms through which adiponectin dampens leptin signalling in vascular smooth muscle cells, thus preventing excess ECM production, in our already established 3

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Entedhar R. Sarhat. "Study the levels of Leptin, and Adiponectin with Paraoxonase in Obese Individuals (male & female)." Tikrit Journal of Pure Science 20, no. 2 (2023): 14–20. http://dx.doi.org/10.25130/tjps.v20i2.1152.

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Obesity is a well-known risk factor of metabolic complications and cardiovascular disease. Associations between anthropometric measurements and fat distribution and risk factors for cardiovascular disease have been demonstrated in several populations. To study the association of various measures of body mass index (BMI), waist circumference (WC), percentage of body fat (%BF), with leptin, Adiponectin, and paraoxonase. To study the association between leptin , adiponectin with Paraoxonase. This study conducted from of February 2013 until March 2014, all individuals were randomly rec

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Cicero, Arrigo F. G., Paolo Magni, Massimo Moré, et al. "Adipokines and Sexual Hormones Associated with the Components of the Metabolic Syndrome in Pharmacologically Untreated Subjects: Data from the Brisighella Heart Study." International Journal of Endocrinology 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/724816.

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We evaluated the association of the sex hormone pattern and the serum level of the main adipokines to metabolic syndrome (MS) and its components in 199 pharmacologically untreated subjects. Men and women included in the age-class subgroups were matched for body mass index, waist circumference, blood pressure, heart rate, fasting plasma glucose, and plasma lipids. Men without MS had significantly lower leptin/adiponectin ratio than men with MS. Women without MS had lower leptin and leptin/adiponectin ratio than women with MS but had significantly higher adiponectin, estrone, and dehydroepiandro

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Marques, Vanda, Fabiola Arella, Marta B. Afonso, André A. Santos, and Cecília M. P. Rodrigues. "Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer." Clinical Science 137, no. 15 (2023): 1095–114. http://dx.doi.org/10.1042/cs20230411.

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Abstract The increasing prevalence of obesity brings forward its importance as a risk factor for cancer development, particularly in the gastrointestinal tract. Obesity may trigger cancer development through several mechanisms, where metabolic deregulation of adipokines can modulate multiple oncogenic molecular pathways. Leptin and adiponectin are the most well-studied adipokines, and their imbalance can trigger different tumorigenic responses. Both epidemiologic and experimental studies have associated leptin with increased cancer risk and cell responsiveness in carcinogenesis and tumor invas

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Mariani, Stefania, Maria Rosaria Di Giorgio, Erica Rossi, et al. "Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa." Nutrients 12, no. 11 (2020): 3506. http://dx.doi.org/10.3390/nu12113506.

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Sirtuin 1 (SIRT1) is a sensor of cell energy availability, and with leptin and adiponectin, it regulates metabolic homeostasis. Widely studied in tissues, SIRT1 is under evaluation as a plasmatic marker. We aimed at assessing whether circulating SIRT1 behaves consistently with leptin and adiponectin in conditions of deficiency, excess or normal fat content. Eighty subjects were evaluated: 27 with anorexia nervosa (AN), 26 normal-weight and 27 with obesity. Bloodstream SIRT1, leptin and adiponectin (ELISA), total and trunk fat mass (FM) %, abdominal visceral adipose tissue, liver steatosis and

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Downs, Taylor, Fabricio da Silva Costa, Cristiane de Freitas Paganoti, Olivia J. Holland, and Deanne H. Hryciw. "Adiponectin and Leptin during Pregnancy: A Systematic Review of Their Association with Pregnancy Disorders, Fetal Growth and Placental Function." Endocrines 5, no. 3 (2024): 382–94. http://dx.doi.org/10.3390/endocrines5030028.

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During pregnancy, the adipokines leptin and adiponectin can affect placental nutrient transport and inflammatory pathways, potentially leading to altered fetal growth and pregnancy complications including gestational diabetes mellitus (GDM) and preeclampsia (PE). The aim of this systematic review is to gather and analyze research on maternal circulating leptin and adiponectin levels and their relationship to adverse pregnancy and birth outcomes. Additionally, it seeks to determine whether these hormones are linked to alterations in placental transporters and cell signaling pathways. PubMed and

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Tan, Karen, Mya Thway Tint, Navin Michael, et al. "Determinants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution." International Journal of Obesity 46, no. 3 (2021): 637–45. http://dx.doi.org/10.1038/s41366-021-00975-3.

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Abstract Background Cord blood leptin and adiponectin are adipokines known to be associated with birth weight and overall infant adiposity. However, few studies have investigated their associations with abdominal adiposity in neonates. We examined maternal factors associated with cord blood leptin and adiponectin, and the association of these adipokines with neonatal adiposity and abdominal fat distribution measured by magnetic resonance imaging (MRI) in an Asian mother–offspring cohort. Methods Growing Up in Singapore Towards healthy Outcomes (GUSTO), is a prospective mother–offspring birth c

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Jayraj, Aarthi S., Sunesh Kumar, Daya Nand Sharma, et al. "The serum levels of leptin and adiponectin in endometrial carcinoma and their association with histopathological factors." Journal of Cancer Research and Therapeutics 21, no. 1 (2025): 98–103. https://doi.org/10.4103/jcrt.jcrt_480_24.

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ABSTRACT Introduction: Adipokines like leptin and adiponectin are hypothesized to play a role in the development of obesity-related cancers like endometrial cancers by influencing inflammation, angiogenesis, apoptosis, and tumorigenesis. We aimed to study the association between serum leptin and adiponectin and the risk of endometrial cancer. Methods: We conducted a case-control study to determine the serum levels of leptin and adiponectin in 55 cases of newly diagnosed endometrial cancer and 25 cases of matched controls. We also sought to determine the association between serum adipokine leve

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Zeman, M., R. Jirák, M. Vecka, et al. "MS247 LEPTIN, ADIPONECTIN AND LEPTIN TO ADIPONECTIN RATIO IN DEPRESSIVE WOMEN." Atherosclerosis Supplements 11, no. 2 (2010): 159. http://dx.doi.org/10.1016/s1567-5688(10)70748-0.

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Shen, Liuhong, Yingkun Zhu, Jinbang Xiao, et al. "Relationships between placental adiponectin, leptin, visfatin and resistin and birthweight in cattle." Reproduction, Fertility and Development 32, no. 4 (2020): 402. http://dx.doi.org/10.1071/rd18247.

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Adipokines can affect intrauterine development while calf birthweight (CBW) is a breeding standard of calves, which reflects the status of fetal intrauterine development. To explore the correlation between placental adipokines and CBW, 54 healthy Chinese Holstein cows were used in the present study. The cows were grouped according to the CBW of their calves. Placentas were collected immediately after delivery and enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction were used to detect the placental expression levels of adiponectin, leptin, visfatin and resistin

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Vasileiadis, Georgios K., Sergi Sayols, Sizheng Steven Zhao, Tahzeeb Fatima, and Cristina Maglio. "Adipokines and risk of rheumatoid arthritis: A two-sample multivariable Mendelian randomisation study." PLOS ONE 18, no. 6 (2023): e0286981. http://dx.doi.org/10.1371/journal.pone.0286981.

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Adiponectin, leptin, and resistin are thought to be involved in the pathogenesis of rheumatoid arthritis (RA). However, the causal relationship between these adipokines and the risk for RA is unclear. We performed a range of two-sample Mendelian randomisation (MR) analyses to assess the causal effect of circulating adiponectin, leptin, and resistin on RA risk in European and East Asian individuals. Different sets of adiponectin-, leptin-, and resistin-related genetic variants were used as instruments for genetically determined adipokine levels. As body mass index (BMI) is a risk factor for RA

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Mahashweta, Das, Saha Ishita, Sinha Prasenjit, Medda Sunit Kumar, and Das Rabindra Nath. "Glucose and insulin levels’ linkages with breast cancer factors." Global Journal of Obesity, Diabetes and Metabolic Syndrome 9, no. 1 (2022): 020–25. http://dx.doi.org/10.17352/2455-8583.000057.

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Serum lipid and glucose metabolisms are considered as the intermediary mechanisms for connecting obesity and Breast Cancer (BC). The article aims to identify the linkages between diabetes biochemical factors such as glucose & insulin and BC biochemical factors such as Monocyte Chemoattractant Protein-1 (MCP-1), adiponectin, Homeostasis Model Assessment score Insulin Resistance (HOMA-IR), resistin, leptin. These objectives can be focused on the two separate statistical models of glucose & insulin based on the remaining factors. From the mean model of glucose, it is observed that mean gl

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Fisher, Alexander, Wichat Srikusalanukul, Michael Davis, and Paul Smith. "Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture." International Journal of Endocrinology 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/684323.

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Introduction. Experiments on genetically modified animals have discovered a complex cross-regulation between adipokines (leptin, adiponectin) and osteocalcin. The relationships between these molecules in human osteoporosis are still unclear. We evaluated the hypothesis of a bidirectional link between adipokines and osteocalcin.Materials and Methods. In a cross-sectional study of 294 older patients with osteoporotic hip fracture, we estimated serum concentrations of leptin, adiponectin, resistin, osteocalcin, parameters of mineral metabolism, and renal function.Results. After adjustment for mul

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Oliveira, Miriane de, Maria Teresa De Síbio, Regiane Marques Castro Olimpio, Fernanda Cristina Fontes Moretto, Renata de Azevedo Melo Luvizotto, and Celia Regina Nogueira. "Triiodothyronine modulates the expression of leptin and adiponectin in 3T3-L1 adipocytes." Einstein (São Paulo) 13, no. 1 (2015): 72–78. http://dx.doi.org/10.1590/s1679-45082015ao3068.

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Objective To study the effect of different doses of triiodothyronine on gene expression of the adipokines leptin and adiponectin, at different times, and to evaluate the difference in expression between the two adipokines in each group. Methods 3T3-L1 adipocytes were incubated with triiodothyronine at physiological dose (10nM) and supraphysiological doses (100nM or 1,000nM), or without triiodothyronine (control, C) for 0.5, 6, or 24 hours. Leptin and adiponectin mRNA was detected using real-time polymerase chain reaction (RT-PCR). One-way analyses of variance, Tukey’s test or Student’s t test,

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Pejsova, Hana, Jaroslav A. Hubacek, Petra Zemankova, and Lukas Zlatohlavek. "Baseline Leptin/Adiponectin Ratio is a Significant Predictor of BMI Changes in Children/Adolescents after Intensive Lifestyle Intervention." Experimental and Clinical Endocrinology & Diabetes 127, no. 10 (2019): 691–96. http://dx.doi.org/10.1055/a-0859-7041.

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Abstract Introduction Abdominal obesity is a strong cardiometabolic risk factor that often occurs as early as in childhood. The negative effect of abdominal obesity on the metabolism is partially mediated by changes to the production of the major adipocyte hormones leptin and adiponectin. Leptin/adiponectin imbalance is associated with increased risk of developing obesity and type 2 diabetes mellitus. Aim To determine whether leptin, adiponectin and the leptin/adiponectin ratio are significant predictors of body weight loss in intensively treated children/adolescents. Methods 183 paediatric ov

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Sennello, Joseph A., Raja Fayad, Alison M. Morris, et al. "Regulation of T Cell-Mediated Hepatic Inflammation by Adiponectin and Leptin." Endocrinology 146, no. 5 (2005): 2157–64. http://dx.doi.org/10.1210/en.2004-1572.

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Abstract Concanavalin A-induced hepatotoxicity was compared in lipodystrophic aP2-nSREBP-1c transgenic mice (LD mice) lacking adipose tissue, obese leptin-deficient ob/ob mice, and lean wild-type (WT) mice. Serum leptin and adiponectin were low in LD mice, whereas ob/ob mice had undetectable leptin, but high adiponectin. Protection from hepatotoxicity was observed in ob/ob, but not in LD mice, despite low cytokine levels and reduced T cell activation and hepatic natural killer T cells in both groups. Administration of adiponectin protected LD mice from hepatotoxicity without altering cytokine

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Polito, Rita, Ersilia Nigro, Ausilia Elce, et al. "Adiponectin Expression Is Modulated by Long-Term Physical Activity in Adult Patients Affected by Cystic Fibrosis." Mediators of Inflammation 2019 (September 9, 2019): 1–7. http://dx.doi.org/10.1155/2019/2153934.

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Cystic fibrosis (CF) is a genetic disease characterized by progressive decline of lung function and chronic airway inflammation. Adipose tissue, through adiponectin and leptin, exerts several effects on energy metabolism and inflammatory processes. This study evaluated the levels of adiponectin and leptin in adult healthy subjects, in patients with CF and their correlation with long-term physical activity. CF patients were divided into two groups (sedentary versus active) based on their regular physical activity over 3 years. Anthropometric and serum biochemical profiles of CF patients and con

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Syk, M., M. Ramklint, R. Fredriksson, L. Ekselius, and J. L. Cunningham. "Elevated total plasma-adiponectin is stable over time in young women with bulimia nervosa." European Psychiatry 41, no. 1 (2017): 30–36. http://dx.doi.org/10.1016/j.eurpsy.2016.09.006.

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AbstractBackgroundBulimia nervosa (BN) is characterized by dysregulated eating behaviour and present data suggest adipokines may regulate food intake. We investigated a possible association between BN and adipokine levels and hypothesized that plasma (P)-adiponectin would be elevated and P-leptin and P-leptin-adiponectin-ratio would be reduced in women with BN.MethodsThe study was designed as a cross-sectional study with a longitudinal arm for patients with BN. Plasma-adiponectin and leptin was measured in 148 female patients seeking psychiatric ambulatory care and 45 female controls. Fifteen

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Vasileva, L. B., M. S. Artemyeva, Yi Ma, et al. "The effect of obesity, impaired carbohydrate metabolism and bariatric surgery on adiponectin and leptin mRNA levels in different adipose tissue depots." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 25, no. 5 (2020): 568–76. http://dx.doi.org/10.18705/1607-419x-2019-25-5-568-576.

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Objective. To determine the effect of morbid obesity, impaired carbohydrate metabolism and bariatric surgery on adiponectin and leptin mRNA levels in subcutaneous and visceral adipose tissue.Design and methods. The study included 30 obese female patients. Eleven patients had co-existent impaired carbohydrate metabolism. The control group consisted of 10 healthy non-obese women. In all obese patients, subcutaneous and visceral adipose tissue samples were taken during bariatric surgery. In obese patients 1 year after the intervention and in control individuals subcutaneous adipose tissue samples

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Agostinis-Sobrinho, César A., Edmar Lacerda Mendes, Carla Moreira, et al. "Association between Leptin, Adiponectin, and Leptin/Adiponectin Ratio with Clustered Metabolic Risk Factors in Portuguese Adolescents: The LabMed Physical Activity Study." Annals of Nutrition and Metabolism 70, no. 4 (2017): 321–28. http://dx.doi.org/10.1159/000477328.

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Introduction: Circulating leptin and adiponectin levels have been associated with impaired vascular function, insulin resistance, and acute cardiovascular evens. This study aimed to evaluate the associations of leptin, adiponectin, and the leptin/adiponectin (L/A) ratio with a clustering of metabolic risk factors (MRF) in adolescents aged 12-18 years. Methods: This is a cross-sectional analysis with 529 Portuguese adolescents aged 12-18 years. Blood samples were taken to analyze total cholesterol (TC) and high-density lipoprotein (HDL) cholesterol (HDL-c), triglycerides glucose, insulin, lepti

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Kyriakakou, Marialena, Ariadne Malamitsi-Puchner, Helen Militsi, et al. "Leptin and adiponectin concentrations in intrauterine growth restricted and appropriate for gestational age fetuses, neonates, and their mothers." European Journal of Endocrinology 158, no. 3 (2008): 343–48. http://dx.doi.org/10.1530/eje-07-0692.

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ObjectiveLeptin and adiponectin are two adipocytokines that play a critical role in the control of energy balance and metabolism as well as in conditions, such as insulin resistance, inflammation, and the development of the metabolic syndrome in adult life. Leptin has been associated with asymmetric intrauterine growth restriction (IUGR). The aim of this study was to investigate the perinatal implication of leptin and adiponectin in IUGR.DesignLeptin and adiponectin were measured in the plasma of 40 mothers, in the umbilical cord (UC) blood of their 20 appropriate for gestational age (AGA) and

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Nazarmamoori, Afrah Al, Mufeedjalil Ewadh, and Suhayr Essa Alqaysi. "LEPTIN AND ADIPONECTIN LEVELS OF ASTHMATIC IRAQI CHILDREN IN HILLA PROVINCE." Asian Journal of Pharmaceutical and Clinical Research 10, no. 12 (2017): 431. http://dx.doi.org/10.22159/ajpcr.2017.v10i12.20394.

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Objective: To assess the serum leptin and adiponectin in Iraqi children with asthma and compare it with healthy controls in Hilla province.Methods: Leptin and adiponectin were measured in 100 children; 60 newly diagnosed with asthma and 40 non-asthmatic children with a comparable age and sex were enrolled in this study. Asthmatic children subdivided into two groups; 30 patients in each group (obese and non-obese). The age of patients and control ranged between 2 and 12 years. The study was conducted in the Department of Biochemistry, College of Medicine, University of Babylon, leptin and adipo

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