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Dissertations / Theses on the topic 'Adipose-derived mesenchymal stem cell'

Author: Grafiati

Published: 11 March 2023

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1

ANGHILERI, Elena. "Adipose-derived mesenchymal stem cells: neuronal differentiation potential and neuroprotective action." Doctoral thesis, Università degli Studi di Verona, 2010. http://hdl.handle.net/11562/343866.

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Le cellule mesenchimali staminali adulte derivate dal tessuto adipose (Adipose Stem Cell, ASC) rappresentano, nell’ambito della terapia cellulare, un’alternativa valida agli altri tipi di cellule staminali (Stem Cell, SC) poichè si possono ottenere in ampia quantità dal tessuto adipose, possono esser facilmente coltivate in laboratorio ed espanse. Abbiamo investigato in vitro il potenziale differenziativo delle ASC in senso neuronale usando due tipi di approcci: un trattamento chimico ed un protocollo prolungato in 2 fasi, che include la formazione di sfere e il sequenziale trattamento BDNF (b

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Brown, Alice Clare. "Generating hair follicle inductive dermal papillae cells from adipose derived mesenchymal stem cells." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29596.

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Current management options for cutaneous burn wounds, including split thickness skin grafts and cultured epithelial autografts, generate an epithelial barrier which lacks a dermal layer and skin adnexae including hair follicles and sebaceous glands. This results in a loss of pliability and contractures that cause functional and cosmetic impairment. Embryological hair follicle morphogenesis results from a complex series of mesenchymal-epithelial interactions and to date a method of generating de novo folliculogenesis from human cells has yet to be accomplished. Existing models rely on combining

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Banani, M. A., M. Rahmatullah, N. Farhan, et al. "Adipose tissue-derived mesenchymal stem cells for breast tissue regeneration." Future Medicine, 2021. http://hdl.handle.net/10454/18391.

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Yes<br>With an escalating incidence of breast cancer cases all over the world and the deleterious psychological impact that mastectomy has on patients along with several limitations of the currently applied modalities, it's plausible to seek unconventional approaches to encounter such a burgeoning issue. Breast tissue engineering may allow that chance via providing more personalized solutions which are able to regenerate, mimicking natural tissues also facing the witnessed limitations. This review is dedicated to explore the utilization of adipose tissue-derived mesenchymal stem cells for brea

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Edbom, Katarina. "Characterization of adipose derived mesenchymal stem cells received via automated extraction." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-48506.

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MacKay, Maria-Danielle L. "Characterization of Medullary and Human Mesenchymal Stem Cell-Derived Adipocytes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1232775772.

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Prasad, Ankur. "The role of aortic carboxypeptidase-like protein in adipose-derived mesenchymal stem cell adipogenesis and fibrosis." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12193.

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Thesis (M.A.)--Boston University<br>The prevalence of obesity and obesity related diseases are increasing worldwide. Obesity is characterized by the pathological expansion of white adipose tissue. Previous studies on white adipose tissue of obese individuals have detected inflammation and fibrosis. These conditions may cause dysregulation of the tissue, leading to negative outcomes, including type II diabetes and metabolic syndrome. Aortic carboxypeptidase-like protein (ACLP) is a secreted extracellular matrix protein that is upregulated in fibrotic lung tissue. Importantly ACLP knockout mice

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PITRONE, Maria. "ISOLATION AND CHARACTERIZATION OF VISCERAL- AND SUBCUTANEOUS ADIPOSE-DERIVED MESENCHYMAL STEM CELLS: PUTATIVE ROLE IN OBESITY AND METABOLIC SYNDROME." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91235.

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Wong, Andrew P. "REGENERATIVE POTENTIAL OF MESENCHYMAL STEM CELL DERIVED EXOSOMES." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5856.

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Bone defects are a pervasive complication arising from many clinical conditions, both mechanical and pathological. Current treatments for large bony defects focus on applying bone grafts or synthetic materials to the defect area. Cell-based—and especially stem-cell—therapies have advanced greatly thanks to increasing attention focused on their ability to generate new tissues in situ with biomechanical properties approaching that of native tissue, but they suffer from their own shortcomings as well. Exosomes have been shown to play critical roles in cell-signaling and tissue regeneration and ar

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Lin, Wenyu. "Investigating the immunomodulatory properties of human embryonic stem cell-derived mesenchymal stem cells." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/7060.

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The immunosuppressive property of mesenchymal stem cells (MSC) has been utilised to ameliorate autoimmune reactions such as graft-versus-host disease. However, variation exists in primary MSC isolated due to differences in donor age and tissue of origin. Alternatively, human embryonic stem cells (hESC) can be differentiated to homogeneous populations of MSC (hESCMSC), thus providing an unlimited source of MSC for cell therapy. In this study, the immunomodulatory properties of two hESC-MSC lines, hESC-MSC1 and hESC-MSC2, were compared with adult bone marrow-derived MSC (BM-MSC) and neonatal for

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AL, HAJ GHINA. "EFFECTS OF LIPID MIXTURE AND A SELECTIVE PPARG MODULATOR ON THE DIFFERENTIATION CAPABILITIES OF HUMAN DERIVED MESENCHYMAL STEM CELLS(HADSCS) DERIVED FROM HEALTHY AN D BREAST CANCER PATIENTS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/784157.

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La sindrome metabolica è associata a molte complicanze che portano in particolare a malattie potenzialmente letali come l'obesità e il cancro. Per essere in grado di identificare soluzioni e trattamenti efficaci, dobbiamo indagare le cause alla base di questa sindrome. La nutrizione è un fattore importante da considerare nella prevenzione e nel trattamento della sindrome metabolica. La nutrizione ha effetto su quasi tutti i meccanismi del metabolismo del corpo umano, anche sull’adipogenesi Negli ultimi anni, è stato posto un enorme interesse sulo studio dell'adipogenesi in relazione sopr

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Morash, Taryn May. "Investigating the regenerative effects of adipose-derived mesenchymal stem cell conditioned media on sarcopenic and progeric skeletal muscle." Thesis, University of Reading, 2018. http://centaur.reading.ac.uk/80706/.

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Ageing, defined as the progressive deterioration of molecular, cellular, tissue and whole organism function, is a primary risk factor for numerous diseases, such as cardiovasculature disease, neurodegeneration and cancer. In recent years, advances in our knowledge of key determinant mechanisms that underpin ageing decline, drives the notion that these features can be attenuated and targeted therapeutically, enabling elderly individuals to experience an enhanced quality of life into advanced old age. Sarcopenia comprises the age-related loss of muscle mass, quality and function and contributes

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Lazin, Jamie Jonas. "The effect of age and sex on the number and osteogenic differentiation potential of adipose-derived mesenchymal stem cells." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34696.

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It has been shown that stem cells exist within adult adipose tissue. These stem cells are named adipose-derived mesenchymal stem cells (ASCs), are derived from the mesoderm, and can differentiate into a number of cells including osteoblasts, chondrocytes, and adipocytes. However, before these cells can be used clinically it is important that we understand how factors like age, sex, and ethnicity affect ASC number and potential. Additionally, since men and women vary in their distribution of adipose tissue, it will be important to see if the ideal source of ASCs is different for each sex. The

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Ferng, Alice S., Katherine M. Marsh, Jamie M. Fleming, et al. "Adipose-derived human stem/stromal cells: comparative organ specific mitochondrial bioenergy profiles." SPRINGER INTERNATIONAL PUBLISHING AG, 2016. http://hdl.handle.net/10150/622736.

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Background: Adipose-derived stem/stromal cells (ASCs) isolated from the stromal vascular fraction are a source of mesenchymal stem cells that have been shown to be beneficial in many regenerative medicine applications. ASCs are an attractive source of stem cells in particular, due to their lack of immunogenicity. This study examines differences between mitochondrial bioenergetic profiles of ASCs isolated from adipose tissue of five peri-organ regions: pericardial, thymic, knee, shoulder, and abdomen. Results: Flow cytometry showed that the majority of each ASC population isolated from the adip

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Haines, Lauren E. "Mesenchymal Analysis of Human Pluripotent Stem Cell-Derived Gastrointestinal Organoids." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563873084551926.

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Che, Mohamad Che Anuar. "Human embryonic stem cell-derived mesenchymal stem cells as a therapy for spinal cord injury." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/7047/.

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Traumatic injury to the spinal cord interrupts ascending and descending pathways leading to severe functional deficits of sensory motor and autonomic function which depend on the level and severity of the injury. There are currently no effective therapies for treating such injuries and the adult central nervous system has very limited capacity for repair so that recovery is very limited and functional deficits are usually permanent. Cell transplantation is a potential therapy for spinal cord injury and a range of cell types are being investigated as candidates. Mesenchymal stem cells (MSCs) ob

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Visweswaran, Malini. "Implications of the WNT Signalling Pathway for Adipose-derived Mesenchymal Stem Cells in a Breast Tumour Environment." Thesis, Curtin University, 2017. http://hdl.handle.net/20.500.11937/59066.

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This study describes the various roles adipose-derived mesenchymal stem cells (ADSCs) play in a breast tumour environment. The ADSC-derived secreted factors inhibit breast tumour cell growth aspects, whereas the tumour-derived secreted factors transform ADSCs into tumour-associated fibroblasts (TAFs). Additionally, it highlights the role of Wnt antagonist sFRP4 and its peptides to further influence the activity of ADSC-derived secreted factors, to downregulate the transformation of ADSCs into TAFs, and in upregulating the adipogenic differentiation of ADSCs.

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Timper, Katharina. "Human bone marrow- and adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-50498.

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Upchurch, David A. "Administration of adipose-derived stromal vascular fraction and platelet rich plasma in dogs with coxofemoral osteoarthritis." Thesis, Kansas State University, 2015. http://hdl.handle.net/2097/19769.

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Master of Science<br>Department of Clinical Sciences<br>Walter Renberg<br>Objective: To evaluate the safety and effect of a single simultaneous intra-articular and intravenous injection of autologous adipose-derived stromal vascular fraction (SVF) and platelet rich plasma (PRP) on coxofemoral osteoarthritis (OA) in dogs. Methods: This was a randomized, double-blind, placebo-controlled prospective pilot trial of simultaneous intra-articular and intravenous SVF and PRP for coxofemoral OA. Dogs with coxofemoral OA causing signs of lameness or discomfort were evaluated by orthopedic exam, visua

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Amodeo, G. "THERAPEUTIC EFFECT OF HUMAN ADIPOSE-DERIVED STEM CELLS AND THEIR SECRETOME IN EXPERIMENTAL DIABETES: FOCUS ON NEUROPATHIC PAIN." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/544157.

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Diabetes mellitus is one of the most common and serious chronic disease in the world. Although the number of available agents to manage diabetes continues to rapidly expand, treatment of diabetes complications, such as neuropathy that is one of the most frequent complication of diabetes mellitus, remains a substantial challenge [Aring et al., 2005]. Pathophysiology of diabetic neuropathy is complex and not fully elucidated; it has multipathogenic mechanisms that cause a diversity of physical symptoms: allodynia, hyperalgesia, numbness and cutaneous ulceration [Vinik et al., 1995]. Persistent N

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Burrow, Kimberley Louise. "The influence of donor age and in vitro expansion on the proliferation and differentiation properties of donor-matched bone marrow and adipose-derived mesenchymal stem cells : implications for musculoskeletal tissue engineering." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-influence-of-donor-age-and-in-vitro-expansion-on-the-proliferation-and-differentiation-properties-of-donormatched-bone-marrow-and-adiposederived-mesenchymal-stem-cells-implications-for-musculoskeletal-tissue-engineering(3c8f388c-8886-47b3-bcde-afe85787fd0c).html.

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Introduction: Mesenchymal stem cells (MSC) offer a novel cell therapy within tissue engineering and regenerative medicine (TERM)-based strategies, and the prospect of MSC therapies are widening since the discovery of MSCs within multiple locations of the body including bone marrow (BM-MSCs) and adipose tissue, (AD-MSCs). It is highly recognised that an organisms reparative and regenerative potential declines with advancing age, therefore aged patients are one of the primary target populations for TERM applications. Although information is available regarding the effects of patient age on the q

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Nishikawa, Gen. "Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression via CCR5." Kyoto University, 2019. http://hdl.handle.net/2433/244520.

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GRISAFI, Federica. "3D in Suspension versus 2D in Adhesion: molecular profiles in stemness and mesenchymal differentiation of Spheroids from Adipose-derived Stem Cells." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/480208.

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Purpose: Adipose stem cells (ASCs) represent a reliable source of stem cells with a widely demonstrated potential in regenerative medicine and tissue engineering applications. New recent insights suggest that three-dimensional (3D) models may closely mimic the native tissue properties; spheroids from adipose derived stem cells (S-ASCs) exhibit enhanced regenerative abilities compared with those of 2D models. Stem cell therapy success is determined by “cell-quality”; for this reason, microRNA profiles, the involvement of stress signals and cellular aging need to be further investigated. Materi

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Nakamura, Yoko. "Enhanced wound healing by topical administration of mesenchymal stem cells transfected with stromal cell-derived factor-1." Kyoto University, 2014. http://hdl.handle.net/2433/185196.

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Donnelly, Jessica M. "Inflammation-Induced Activation of Bone Marrow-Derived Mesenchymal Stem Cells During Gastric Disease." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380613253.

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Lei, Lin. "Identification of portal mesenchymal stem cells and derived myofibroblasts in liver fibrosis." Thesis, Sorbonne université, 2020. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2020SORUS099.pdf.

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Les travaux antérieurs ont montré que les myofibroblastes portaux (PMFs) contribuaient de manière significative à la fibrogenèse et à l'angiogénèse dans la fibrose hépatique. L'objectif principal de cette thèse était de cartographier les cellules mésenchymateuses portales, et plus particulièrement la niche des cellules souches mésenchymateuses portales. Nous avons caractérisé la variété des cellules mésenchymateuses portales du foie de souris. Résultat important, nous avons identifié une population de cellules mésenchymateuses portales ayant les caractéristiques de cellules souches mésenchymat

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Morse, Zachary J. "Dose Response Analysis of Bone Marrow-Derived Mesenchymal Stem Cells for Treatment in Fascial Wound Repair." Youngstown State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1444052561.

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Van, Vollenstee Fiona A. "Isolation and characterization of human adipose derived mesenchymal stem cells and production of GFP-labeled primary cells for in vivo tracking following transplantation." Diss., University of Pretoria, 2015. http://hdl.handle.net/2263/45939.

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Introduction It is well known that resident adipose stem/stromal cells (ASCs) are a heterogeneous population of multipotent cells characterized by (a) their ability to adhere to plastic; (b) immunophenotypic expression of certain cell surface markers, while lacking others; and (c) the capacity to differentiate into cells of mesodermal origin including osteocytes, chondrocytes and adipocytes. Adipose derived stromal cells offer great therapeutic potential in multiple medical fields, including, orthopedics, cardiology, oncology and degenerative diseases, to name a few. Combining different

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Erratico, S. A. "SVILUPPO DI UN MODELLO SPERIMENTALE PER LO STUDIO DEI FATTORI DEGENERATIVI CHE INDUCONO IL DIFFERENZIAMENTO ADIPOCITARIO DI CELLULE STAMINALI MESENCHIMALI." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/169910.

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In adult tissues, somatic stem cells represent a cell reservoir involved in physiological or pathological cell replacement within healthy or damaged tissue. Thanks to specific molecular or physical signals of the microenvironment, homeostasis process is guaranteed inside stem cell niches. Factors deriving from pathological events induce a shift in stem cell behaviour to cell differentiation, in order to reconstitute cell populations lost in the damaged tissue. In several myopathies, chronic inflammation is a part of pathological process that causes fibrotic infiltrations and adipose depositio

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Zampar, Antonio Gustavo. "Análise de células mesenquimais multipotentes derivadas de diferentes áreas doadoras de tecido adiposo e sua influência sobre fibroblastos in vitro." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-08012019-154153/.

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A cicatrização de feridas crônicas e de defeitos complexos representam desafios para a cirurgia plástica reconstrutiva. Novos tratamentos emergiram com a utilização de células tronco mesenquimais, com especial interesse para as derivadas de tecido adiposo (CTMs-TA), por possuir algumas vantagens em relação às derivadas da medula óssea. Algumas doenças poderiam se beneficiar com o uso das CTMs-TA, em particular, as feridas de pacientes portadores de anemia falciforme que ainda representam um desafio terapêutico. Neste estudo, investigou-se a existência de possíveis áreas doadoras preferenciais

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Sanders, Douglas N. "Autologous bone marrow-derived mesenchymal stem cell transplantation as a therapy for neuronal ceroid lipofuscinosis." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4830.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "August 2007" Includes bibliographical references.

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Ghosh, Deepraj. "Soluble factor mediated manipulation of mesenchymal stem cell mechanics for improved function of cell-based therapeutics." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54032.

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Mesenchymal stem cells (MSCs) are bone marrow derived multipotent cells with the ability to self-renew and differentiate into multiple connective cell lineages. In vivo, MSCs travel from the bone-marrow to the inflammatory sites and actively participate in remodeling and regeneration process under the influence of soluble growth factors. Due to these inherent properties, MSCs have emerged as an ideal candidate for diverse regenerative therapeutic applications. The development of MSC-based therapies requires in vitro expansion of MSCs; however, MSC expansion results in phenotypical changes that

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Hansen, Katrina J. "Development of a Human Mesenchymal Stem Cell and Pluripotent Stem Cell Derived Cardiomyocyte Seeded Biological Suture for Cell Delivery to Cardiac Tissue for Cardiac Regeneration Applications." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-dissertations/420.

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"Recent data show that 7.6 million Americans have survived a myocardial infarction (MI), and 5.1 million Americans suffer from severe heart failure. Stem cell therapy has the potential to improve cardiac function after MI. Two promising cells for cardiovascular regeneration therapies include human mesenchymal stem cells (hMSCs) and pluripotent stem cell derived cardiomyocytes (hPS-CM) each with their own unique method for improving cardiac function post-infarct. However, a limiting factor to cell therapies is that the methods currently used to deliver cells to the myocardium, including intramy

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Li, Xiang. "Mitochondrial transfer from induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial and smooth muscle cells attenuates oxidative stress-induced injury." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/58260.

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Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by persistent airflow limitation that is not fully reversible and is usually caused by cigarette smoke (CS). The disease is predicted to be the fourth leading cause of death by 2030, but none of the currently available treatments can alleviate the progressive decline in lung function. Mesenchymal stem cells (MSCs) are fibroblast-like multipotent stem cells that can be isolated from various tissues such as bone marrow (BM-MSCs). Despite numerous reports of their efficacy in COPD-related pre-clinical mod

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Shell, Katja Nadine [Verfasser]. "The influence of hypoxia, strain and growth differentiation factors on equine adipose tissue derived mesenchymal stem cells : a study to improve stem cell differentiation in vitro for their future application in vivo / Katja Nadine Shell." Gießen : Universitätsbibliothek, 2012. http://d-nb.info/1064024467/34.

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Fujii, Sumie. "GVHD amelioration by human bone marrow mesenchymal stromal/stem cell-derived extracellular vesicles is associated with peripheral preservation of naive T cell populations." Kyoto University, 2018. http://hdl.handle.net/2433/232136.

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Irons, Hillary Rose. "Bone Marrow-Derived Mesenchymal Stem Cells As an Alternate Donor Cell Source for Transplantation in Tissue-Engineered Constructs After Traumatic Brain Injury." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/16168.

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The incidence and long-term effects of traumatic brain injury (TBI) make it a major healthcare and socioeconomic concern. Cell transplantation may be an alternative therapy option to target prolonged neurological deficits; however, safety and efficacy of the cells must be determined. Bone marrow-derived mesenchymal stem cells (MSCs) are an accessible and expandable cell source which circumvent the many of the accessibility and ethical concerns associated with fetal tissues. A major impediment to recent clinical trials for cell therapies in the central nervous system has been the lack of consis

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Osiecki, Michael J. "Isolation and expansion of placental derived mesenchymal stromal cells in a packed bed bioreactor." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/97947/1/Michael_Osiecki_Thesis.pdf.

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Mesenchymal stromal cells (MSCs) are thought to be useful in wound healing applications, but are not available from human sources in large enough quantities to be clinically viable. To isolate and expand placental derived human MSCs, this project details the design and scale up of a novel packed bed bioreactor that decouples the oxygen supply from the bulk medium flow by allowing oxygen to diffuse through the reactor wall. The design was further optimised through finite element modelling to expand up to 3x10^8 MSCs. In addition, modelling provided insight into the reduced cellular growth rate

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Wilson, Amber Diane. "Determining the Effects of Aging on Murine Bone-Marrow Derived Mesenchymal Stem Cell Cardiac and Angiogenic Plasticity Potential." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/641.

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Reduction of cardiac myocyte loss and repair of the vasculature post myocardial infarction are important therapeutic goals because the potential for intrinsic repair is limited. Preclinical and limited clinical data support the possibility that bone marrow-derived mesenchymal stem cells may be a suitable cell type for cellular therapy. The goal of this research was to determine the effectiveness of using MSCs from aged mice in cellular therapy for the treatment of AMI. The central hypothesis for this research was that therapeutic potential of mesenchymal stem cells decreases with age.

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Mathieu, Myrielle. "Comparison between therapeutic efficiency of bone marrow derived mononuclear and mesenchymal stem cells in chronic myocardial infarction." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210138.

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<p>Background: Stem cell therapy can facilitate cardiac repair after healed myocardial infarction but the optimal cell type remains uncertain. <p>Aims: To investigate the pathophysiology of heart failure in a canine model of healed myocardial infarction and to compare the efficacy and the safety of autologous bone marrow mononuclear cell (BMNC) transfer and mesenchymal stem cell (MSC) transfer in this model. It was a blind, randomized and placebo control study.<p>Methods: Eleven weeks after coronary ligation, 24 dogs received intramyocardial injections of BMNC, MSC or Placebo (n = 8 per groups

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Lang, Siegmund [Verfasser], and Markus [Akademischer Betreuer] Loibl. "Leukocyte-reduced platelet-rich plasma stimulates the in vitro proliferation of adipose-tissue derived mesenchymal stem cells depending on PDGF signaling. / Siegmund Lang ; Betreuer: Markus Loibl." Regensburg : Universitätsbibliothek Regensburg, 2018. http://d-nb.info/1159375844/34.

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Niada, S. "FROM IN VITRO STUDIES TO A LARGE ANIMAL MODEL: A MULTISTEP DISSECTION ON THE FUTURE ROLE OF ADIPOSE-DERIVED STEM CELLS FOR MUSCULOSKELETAL TISSUE ENGINEERING." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229427.

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Tissue engineering is an emerging interdisciplinary field, born with the purpose to provide an alternative solution for the regeneration of lesioned or lost tissues, combining cells, biocompatible scaffolds and bioactive factors. The cells for this approach should be non-immunoreactive and non-tumorigenic. Moreover, they should be available in large amount and possess, or be able to acquire, a specific protein expression pattern similar to that of the damaged tissue and/or act as a pool of trophic factors for resident cells. All these reasons, make mesenchymal stem cells (MSCs) good candidates

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Ettey, Thywill. "An Investigation of Collagen, Platelet-Rich Plasma and Bone Marrow Derived Mesenchymal Stem Cells on Achilles Tendon Repair in a Rat Model." Youngstown State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1559127777520856.

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PROVENZANO, FRANCESCA. "Mesenchymal stem cell-derived exosomes and exosome-shuttled miRNAs ameliorate the reactive and neurotoxic phenotype of mouse SOD1G93A astrocytes and human-derived SOD1A4V astrocytes." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/996729.

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting primarily motor neurons (MNs) but involving also non-neuronal cells. Nowadays, it is well recognised that astrocytes, microglia and oligodendrocytes play a central role in disease onset and progression. In particular, astrocytes acquire a toxic phenotype characterized by an abnormal proliferation and by the release of neurotoxic factors, including pro-inflammatory cytokines (Lee et al., 2016). We have previously shown that the intravenous administration of mesenchymal stem cells (MSCs) in SOD1G93A mice prolonged

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Lovati, A. B. "COMPARISON OF EQUINE BONE MARROW-, UMBILICAL CORD MATRIX-, AMNIOTIC FLUID- AND TENDON-DERIVED PROGENITOR CELLS." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150197.

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Mesenchymal stem cells have been recently investigated for their potential use in regenerative medicine. It has been suggested that there may be a stem cell population within both umbilical cord matrix and amniotic fluid. However, little knowledge exists about the characteristics of these progenitor cells within these sources in the equine species. This study wanted to investigate an alternative and non-invasive stem cell source for the equine tissue engineering and to learn more about the properties of these cells for future cell banking. Moreover, population of adult stem cells were recently

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Höfner, Christiane [Verfasser], Torsten [Gutachter] Blunk, Matthias [Gutachter] Becker, and Norbert [Gutachter] Schütze. "Human Adipose-derived Mesenchymal Stem Cells in a 3D Spheroid Culture System - Extracellular Matrix Development, Adipogenic Differentiation, and Secretory Properties / Christiane Höfner ; Gutachter: Torsten Blunk, Matthias Becker, Norbert Schütze." Würzburg : Universität Würzburg, 2020. http://d-nb.info/121086231X/34.

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Rony, R. M. Imtiaz Karim. "Transcriptional characterization of osteogenic and adipogenic differentiation of human bone marrow derived mesenchymal stem cells in 2D and 3D peptide hydrogel culture system." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1536841298659517.

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LOSURDO, MORRIS. "A NEW HOPE FOR ALZHEIMER’S DISEASE FROM PRECONDITIONED BONE MARROW MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES: ANALYSIS OF THE IMMUNOMODULATORY EFFECTS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241093.

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La malattia di Alzheimer (AD), la forma più comune di demenza senile, è caratterizzata da una progressiva degenerazione del sistema nervoso centrale (SNC) che conduce ad un declino della funzione cognitiva e a perdita di memoria. I tratti caratteristici dell’AD includono placche extracellulari di beta amiloide (Abeta), grovigli neurofibrillari (NFTs), neuriti distrofici, morte neuronale e attivazione gliale. In base a quanto affermato dall’ “Ipotesi della cascata della Abeta” - la teoria più corroborata nell’ambito degli studi sull’AD negli ultimi decenni – la neuroinfiammazione veniva suppost

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Singh, Sanjleena. "Characterisation of mesenchymal cells from osteophytes in osteoarthritis." Thesis, Queensland University of Technology, 2009. https://eprints.qut.edu.au/31298/1/Sanjleena_Singh_Thesis.pdf.

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Osteophytes form through the process of chondroid metamorphosis of fibrous tissue followed by endochondral ossification. Osteophytes have been found to consist of three different mesenchymal tissue regions including endochondral bone formation within cartilage residues, intra-membranous bone formation within fibrous tissue and bone formation within bone marrow spaces. All these features provide evidence of mesenchymal stem cells (MSC) involvement in osteophyte formation; nevertheless, it remains to be characterised. MSC from numerous mesenchymal tissues have been isolated but bone marrow remai

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Wei, Li-Ning, and 魏立寧. "Topical Allogeneic Adipose-Derived Mesenchymal Stem Cell Therapy in Canine Keratoconjunctivitis Sicca." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/6wxr22.

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碩士<br>國立臺灣大學<br>臨床動物醫學研究所<br>107<br>In the past two decades, mesenchymal stem cells have been tested in the treatment of various diseases and tissue regeneration. Among these mesenchymal stem cells have gradually gained much attention because of their availability, stability, safety, low-ethical issue and with wide ranges of potential therapeutic applications. Bone marrow-derived mesenchymal stem cells were found and used earlier, so the bulk of early studies used them. However, adipose-derived stem cells are much easier to access and can be acquired in a large quantity. Especially when the eu

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Li, Yuan-Sheng, and 李沅賸. "Study of Adipose-Derived Mesenchymal Stem Cells in Diabetic Therapy." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/25927847052562243970.

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博士<br>國立東華大學<br>生命科學系<br>104<br>Diabetes has been one of the top five causes of death in Taiwan for many years. Stem cells provide a promising expectancy for diabetes treatment; however, the efficacy in clinical trial still presents room to improve. Mesenchymal stem cells can be obtained safely and easily from fat tissue, be expanded in vitro with multipotent differentiation ability, and secrete a variety of cytokines. It is therefore that human adipose-derived stem cells (hADSCs) were selected to explore their application for diabetes therapy in this study. In the first part of this study, we

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