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Journal articles on the topic 'Adjusted scoring systems'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Leung, Edmund, Kirsten McArdle, and Ling S. Wong. "Risk-adjusted scoring systems in colorectal surgery." International Journal of Surgery 9, no. 2 (2011): 130–35. http://dx.doi.org/10.1016/j.ijsu.2010.10.016.

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Leung, Edmund, Ali M. Ferjani, Andrew Kitchen, Damian Griffin, Nigel Stellard, and Ling S. Wong. "Risk-adjusted scoring systems can predict surgeons’ performance in colorectal surgery." Surgeon 9, no. 1 (2011): 3–7. http://dx.doi.org/10.1016/j.surge.2010.07.008.

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Leung, Edmund. "Risk-adjusted scoring systems can predict surgeons’ performance in colorectal surgery." Surgeon 9, no. 5 (2011): 293. http://dx.doi.org/10.1016/j.surge.2011.06.004.

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McFarlane, Gordon A., and Brodyn Poulton. "Risk-adjusted scoring systems can predict surgeons’ performance in colorectal surgery." Surgeon 9, no. 5 (2011): 292. http://dx.doi.org/10.1016/j.surge.2011.06.005.

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Sun, Jie, Hui Li, Pei-Chann Chang, and Qing-Hua Huang. "Dynamic credit scoring using B & B with incremental-SVM-ensemble." Kybernetes 44, no. 4 (2015): 518–35. http://dx.doi.org/10.1108/k-02-2014-0036.

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Purpose – Previous researches on credit scoring mainly focussed on static modeling on panel sample data set in a certain period of time, and did not pay enough attention on dynamic incremental modeling. The purpose of this paper is to address the integration of branch and bound algorithm with incremental support vector machine (SVM) ensemble to make dynamic modeling of credit scoring. Design/methodology/approach – This new model hybridizes support vectors of old data with incremental financial data of corporate in the process of dynamic ensemble modeling based on bagged SVM. In the incremental

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Vandenbrande, Jeroen, Laurens Verbrugge, Liesbeth Bruckers, et al. "Validation of the Acute Physiology and Chronic Health Evaluation (APACHE) II and IV Score in COVID-19 Patients." Critical Care Research and Practice 2021 (June 19, 2021): 1–9. http://dx.doi.org/10.1155/2021/5443083.

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Background. Severity scoring systems are inherent to ICU practice for multiple purposes. Acute Physiology and Chronic Health Evaluation (APACHE) scoring systems are designed for ICU mortality prediction. This study aims to validate APACHE IV in COVID-19 patients admitted to the ICU. Methods. All COVID-19 patients admitted to the ICU between March 13, 2020, and October 17, 2020, were retrospectively analyzed. APACHE II and APACHE IV scores as well as SOFA scores were calculated within 24 hours after admission. Discrimination for mortality of all three scoring systems was assessed by receiver op

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Desantis, Darren, Luke Lavallee, Kelsey Witiuk, et al. "The association between renal tumour scoring system components and complications of partial nephrectomy." Canadian Urological Association Journal 9, no. 1-2 (2015): 39. http://dx.doi.org/10.5489/cuaj.2303.

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Introduction: We evaluate the associations between 3 renal tumour scoring systems and their components with perioperative complications of partial nephrectomy.Methods: A consecutive cohort of partial nephrectomy patients was analyzed. Patient characteristics were abstracted from medical records. PADUA scores (preoperative aspects and dimensions used for anatomic classification), RENAL (radius exophyic/endophytic nearness anterior/posterior location scoring) nephrometry scores, and Centrality index (C-index) were determined from preoperative axial images by 2 independent reviewers. Cases were e

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Kweon, Ye-Na, Hae-Jin Ko, A.-Sol Kim, et al. "Prediction of Cardiovascular Risk Using Nonalcoholic Fatty Liver Disease Scoring Systems." Healthcare 9, no. 7 (2021): 899. http://dx.doi.org/10.3390/healthcare9070899.

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This study aimed to determine whether nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for CVD and to identify the most useful NAFLD diagnostic tool for predicting CVD. Data from a total of 23,376 Korean adults without established CVD were analyzed. Cardiovascular risk was calculated using the Framingham Risk Score (FRS) 2008. The presence of NAFLD was defined as moderate-to-severe fatty liver disease diagnosed by ultrasonography. Scores for fatty liver were calculated using four NAFLD scoring systems (Fatty Liver Index, FLI; Hepatic Steatosis Index, HSI; Simple NAFLD Sco

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Yadav, Moorat Singh, Vibhore Agarwal, and Surabhi Garg. "A prospective study of trauma patients at Gandhi Medical College and associated hospital emergency department, Bhopal, analysing anatomical and physiological scoring systems to predict mortality." International Journal of Research in Medical Sciences 5, no. 3 (2017): 871. http://dx.doi.org/10.18203/2320-6012.ijrms20170627.

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Background: Trauma, in a developing country like India, is a leader together with non-communicable diseases, when measured in terms of disability adjusted life years (DALYs) lost. Trauma scoring systems have been shown to decrease the number of preventable deaths caused by trauma. The aim of this study is to compare the various physiological and anatomical scoring systems.Methods: Two hundred and sixty two cases of trauma of adult age group admitted in Gandhi Medical College and Hamidia Hospital, Bhopal, Madhya Pradesh, India from 1 July 2014 to 1 December 2014.Results: Out of the 262 patients

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Liu, Chia-Jen, Hong Ying-Chung, Chiu-Mei Yeh, et al. "An External Validation Study for Current Risk Scoring Models in Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia." Blood 134, Supplement_1 (2019): 3861. http://dx.doi.org/10.1182/blood-2019-129597.

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Background Acute myeloid leukemia (AML) is a common hematologic neoplasm in the elderly. The high mortality in elderly AML patients is reported to be associated with old age, poor performance status, and several disease characteristics. Several risk stratification models have been reported. Our aims were to explore risk factors for early mortality in older AML patients and compare the discrimination ability of existing prognostic models. Methods We enrolled newly diagnosed AML patients age 60 and above at Taipei Veterans General Hospital, a national medical center in Taiwan, between July 1, 20

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Bejanyan, Nelli, Claudio G. Brunstein, Qing Cao, et al. "Predictive value of disease risk comorbidity index for overall survival after allogeneic hematopoietic transplantation." Blood Advances 3, no. 3 (2019): 230–36. http://dx.doi.org/10.1182/bloodadvances.2018018549.

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Abstract Allogeneic hematologic cell transplantation (alloHCT) is the only curative therapy for many adults with hematological malignancies. However, it can be associated with substantial risks of morbidity and mortality that are dependent on patient comorbidity– or disease risk–related factors. Several pretransplantation prognostic scoring systems have been developed to estimate survival of patients undergoing alloHCT; however, there is significant interstudy variability in the predictive capacity of these assessment tools. We tested the prognostic capability of a composite scoring system inc

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Kapliński, Oleg. "USEFULNESS AND CREDIBILITY OF SCORING METHODS IN CONSTRUCTION INDUSTRY/TAŠKŲ SKAIČIAVIMO METODŲ NAUDINGUMAS IR PATIKIMUMAS STATYBOS PRAMONĖJE." JOURNAL OF CIVIL ENGINEERING AND MANAGEMENT 14, no. 1 (2008): 21–28. http://dx.doi.org/10.3846/1392-3730.2008.14.21-28.

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The methods presented in the paper clarify the route of a company towards bankruptcy. The information comes from the so called early warning systems, among which a special attention has been paid to statistical scoring methods. A review of scoring methods informing about the financial standing of a company has been made. Examples have been selected among construction companies listed on Warsaw Stock Exchange. Credibility of models and results has been highlighted. Results point at the fact that the synthetic Z‐score index should be adjusted to economic conditions of a given country, or even to

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Miki, Shoji, Hiroaki Sasaki, Hiroshi Horiuchi, et al. "On-admission SARS-CoV-2 RNAemia as a single potent predictive marker of critical condition development and mortality in COVID-19." PLOS ONE 16, no. 7 (2021): e0254640. http://dx.doi.org/10.1371/journal.pone.0254640.

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Background This study aimed to clarify how SARS-CoV-2 RNAemia is related to COVID-19 critical condition development and mortality in comparison with other predictive markers and scoring systems. Methods This is a retrospective cohort study conducted at Yokohama Municipal Citizen’s Hospital and National Institute of Infectious Diseases. We recruited adult patients with COVID-19 admitted between March 2020 and January 2021. We compared RNAemia with clinical status on admission including scoring systems such as the 4C Mortality, CURB-65, and A-DROP, as well as the Ct value of the nasopharyngeal P

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Obradovic, Dusanka, Biljana Joves, Ivana Vujovic, Marija Vukoja, Srdjan Stefanovic, and Stanislava Sovilj-Gmizic. "Is age-adjusted mews upon admission a relevant prognostic tool for final outcome?" Srpski arhiv za celokupno lekarstvo, no. 00 (2020): 58. http://dx.doi.org/10.2298/sarh181008058o.

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Introduction/Objective. Early warning scoring systems are important for timely identification of the critically ill, but are they a relevant prognostic tool? Our objective was to test if Modified Early Warning Score (MEWS), lactate and base excess (BE) have any prognostic value in high dependency unit (HDU) patients. Methods. This was a prospective observational study that included 364 patients who were treated at respiratory HDU. The values of MEWS, lactate and BE at admission were recorded with patients' age, sex and comorbidities. Negative outcome was defined as death or transfer to Intensi

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Stracke, J., D. Klotz, P. Wohlsein, et al. "Scratch the surface: Histopathology of foot-pad dermatitis in turkeys (Meleagris gallopavo)." Animal Welfare 29, no. 4 (2020): 419–32. http://dx.doi.org/10.7120/09627286.29.4.419.

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Foot-pad dermatitis (FPD) is an important indicator of animal welfare in turkeys (Meleagris gallopavo). The present study aimed to evaluate the reliability and validity of a commonly used five-point visual score (VC), assessing FPD based on lesion size by implementing histopathological analysis. In 100 turkey feet (20 per scale scored by the VC), the size of both the foot-pad and the alteration were measured. Subsequently, a histopathological analysis was performed, examining the occurrence and severity grade of different parameters. The study addressed three main goals: (i) examining the reli

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Dantan, Etienne, Yohann Foucher, Marine Lorent, Magali Giral, and Philippe Tessier. "Optimal threshold estimator of a prognostic marker by maximizing a time-dependent expected utility function for a patient-centered stratified medicine." Statistical Methods in Medical Research 27, no. 6 (2016): 1847–59. http://dx.doi.org/10.1177/0962280216671161.

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Defining thresholds of prognostic markers is essential for stratified medicine. Such thresholds are mostly estimated from purely statistical measures regardless of patient preferences potentially leading to unacceptable medical decisions. Quality-Adjusted Life-Years are a widely used preferences-based measure of health outcomes. We develop a time-dependent Quality-Adjusted Life-Years-based expected utility function for censored data that should be maximized to estimate an optimal threshold. We performed a simulation study to compare estimated thresholds when using the proposed expected utility

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Kaurivi, Yolande Baby, Richard Laven, Rebecca Hickson, Tim Parkinson, and Kevin Stafford. "Assessing Extensive Semi-Arid Rangeland Beef Cow-Calf Welfare in Namibia. Part 2: Categorisation and Scoring of Welfare Assessment Measures." Animals 11, no. 2 (2021): 250. http://dx.doi.org/10.3390/ani11020250.

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This paper aims to develop standards for a welfare assessment protocol by validating potential categorisation thresholds for assessing beef farms in various beef cow-calf production systems in Namibia. Forty measures, combined from a New Zealand-based protocol plus Namibia-specific measures, are applied to 55 beef farms (17 commercial farms, 20 semi-commercial and 18 communal village farms) during pregnancy testing, and a questionnaire guided interview. The categorised measures on a 3-point welfare score (0: good, 1: marginal, and 2: poor/unacceptable welfare) are subsequently compared with th

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Lee, Y., SJ Kim, YS Kim, et al. "The usefulness of the SOFA and APACHE II scoring systems for the early prediction of mortality in patients with dapsone poisoning." Human & Experimental Toxicology 38, no. 3 (2018): 280–87. http://dx.doi.org/10.1177/0960327118806647.

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The rate of mortality from dapsone poisoning is high because of the long absorption half-life of dapsone. This study aimed to evaluate the usefulness of the sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation II (APACHE II) scoring systems for the early prediction of mortality in patients with dapsone poisoning. This is a retrospective and observational study of consecutive patients diagnosed with dapsone poisoning. The SOFA and APACHE II scores were obtained within the first 24 h of admission. Patients were divided into survivor and non-survivor group

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Islam, Mahmudul, Mashfiqul Hasan, Sudipta Kumer Mukherjee, Jobaida Naznin, Rafiqul Islam, and Maliha Hakim. "Predictors of Outcome in Intracerebral Hemorrhage and Performance of Hemphill ICH Score and GVS Score." Journal of National Institute of Neurosciences Bangladesh 7, no. 1 (2021): 3–9. http://dx.doi.org/10.3329/jninb.v7i1.54743.

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Background: The outcome of intracerebral hemorrhage (ICH) is gloomy. There are several scoring systems for predicting its outcome. Objective: The purpose of the present study was to observe the predictors of outcome in ICH patients and to assess the performance of ‘Hemphill ICH score’ and ‘GVS score’. Methodology: This cohort study involved patients of ICH admitted within 72 hours of acute event in July to December 2017 in the Department of Neurology at National Institute of Neurosciences (NINS) & Hospital, Dhaka, Bangladesh. Clinical and radiological data at admission and in-h

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Massaad, Elie, Muhamed Hadzipasic, Christopher Alvarez-Breckenridge, et al. "Predicting tumor-specific survival in patients with spinal metastatic renal cell carcinoma: which scoring system is most accurate?" Journal of Neurosurgery: Spine 33, no. 4 (2020): 529–39. http://dx.doi.org/10.3171/2020.4.spine20173.

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OBJECTIVEAlthough several prognostic scores for spinal metastatic disease have been developed in the past 2 decades, the applicability and validity of these models to specific cancer types are not yet clear. Most of the data used for model formation are from small population sets and have not been updated or externally validated to assess their performance. Developing predictive models is clinically relevant as prognostic assessment is crucial to optimal decision-making, particularly the decision for or against spine surgery. In this study, the authors investigated the performance of various s

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Kareem, Talha, Muhammad Farrukh Aftab, Junaid Hashmi, Muzzafar Aziz, Abdul Hanan Javaid, and Ali Rabbani. "Meld Score: A Reliable Predictor of Mortality and Post Operative Complications in Patients with Chronic Liver Disease Undergoing Non-Transplant Surgeries." Professional Medical Journal 28, no. 03 (2021): 355–60. http://dx.doi.org/10.29309/tpmj/2021.28.03.5019.

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Context: Patients with liver disease are always at high risk of post-operative complications. The prediction of postoperative outcome is very crucial in the management of these patients. Various prediction models are in use to serve this purpose. Childs-Turcotte-Pugh (CTP) and Model of End-Stage Liver Disease (MELD) scoring systems are globally used to predict post-operative mortality in end stage liver disease patients. Aims: To compare the results of CTP and MELD scoring systems for predicting outcome in patients of chronic liver disease and to conclude which model is better for risk s

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Yamakawa, Kazuma, Jumpei Yoshimura, Takashi Ito, Mineji Hayakawa, Toshimitsu Hamasaki, and Satoshi Fujimi. "External Validation of the Two Newly Proposed Criteria for Assessing Coagulopathy in Sepsis." Thrombosis and Haemostasis 119, no. 02 (2018): 203–12. http://dx.doi.org/10.1055/s-0038-1676610.

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Background Two different criteria for evaluating coagulopathy in sepsis were recently released: sepsis-induced coagulopathy (SIC) and sepsis-associated coagulopathy (SAC). Although both use universal haemostatic markers of platelet count and pro-thrombin time, significance and usefulness of these criteria remain unclear. Objective This article validates and evaluates the significance of SIC and SAC criteria compared with the International Society on Thrombosis and Haemostasis (ISTH) overt disseminated intravascular coagulation (DIC) and Japanese Association for Acute Medicine (JAAM) DIC criter

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Jacobsen, Annie M., Jenny Poynter, Michaela Richardson, et al. "Factors Predicting Early Mortality in Newly Diagnosed Myelodysplastic Syndrome (MDS): A Population Based Study." Blood 132, Supplement 1 (2018): 4369. http://dx.doi.org/10.1182/blood-2018-99-112319.

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Abstract Myelodysplastic syndromes (MDS) are a heterogeneous collection of clonal disorders of hematopoietic stem cells characterized by ineffective hematopoiesis, dysplasia, and risk of progression to secondary acute myeloid leukemia (AML). Despite the development of numerous prognostic scoring systems (MDS Comorbidity Index (MDS-CI),International Prognostic Scoring System (IPSS) and IPSS-R, updated WHO classifications, and WHO prognostic scoring system (WPSS)), little prospective data regarding the influence of these and other factors on patient outcomes is available. To better elucidate the

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Pressman, Gregg S., Atif Qasim, Nitin Verma, et al. "Periodontal Disease Is an Independent Predictor of Intracardiac Calcification." BioMed Research International 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/854340.

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Background. Periodontitis is the most common chronic inflammatory condition worldwide and is associated with incident coronary disease.Hypothesis. We hypothesized that periodontal disease would also be associated with cardiac calcification, a condition which shares many risk factors with atherosclerosis and is considered a marker of subclinical atherosclerosis.Methods. Cross-sectional study at two sites (USA and Japan) involving subjects with both clinical echocardiograms and detailed dental examinations. Semiquantitative scoring systems were used to assess severity of periodontal disease and

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Liang, Tiffany W., S. Keisin Wang, Paul D. Dimusto, et al. "Association Between Body Mass Index and Perioperative Mortality After Repair of Ruptured Abdominal Aortic Aneurysms." Vascular and Endovascular Surgery 54, no. 7 (2020): 573–78. http://dx.doi.org/10.1177/1538574420939356.

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Objective: The attempt to repair a ruptured abdominal aortic aneurysm carries a significant risk of perioperative mortality. The relationship between body mass index (BMI) and outcomes after repair of ruptured abdominal aortic aneurysms (AAAs) has not been well defined. We report the association of BMI with outcomes after ruptured AAA repair. Methods: Patients undergoing ruptured AAA repairs between 2008 and 2017 at 2 tertiary academic centers were included in this retrospective study. Demographics (including BMI), type of repair, length of stay, and admission mortality risk scores were gather

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Ramsubeik, Karishma, Shastri Motilal, Luis Sanchez-Ramos, Laurie Ann Ramrattan, Gurjit S. Kaeley, and Jasvinder A. Singh. "Diagnostic accuracy of salivary gland ultrasound in Sjögren’s syndrome: A systematic review and meta-analysis." Therapeutic Advances in Musculoskeletal Disease 12 (January 2020): 1759720X2097356. http://dx.doi.org/10.1177/1759720x20973560.

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Background: To systematically review the diagnostic accuracy of salivary gland ultrasound in primary Sjögren’s syndrome (pSS). Methods: PubMed, Embase, CINAHL, Cochrane Central and Scopus and ClinicalTrials.gov were searched to identify diagnostic or validation studies in patients with pSS meeting the diagnostic criteria. A diagnostic test meta-analysis was performed using a bivariate model to calculate the pooled sensitivity, specificity, positive/negative likelihood ratios, and the diagnostic odds ratio. Meta-regression analyses were done for several pSS covariates. Results: Sixty-five studi

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Hotsuki, Yu, Yu Sato, Akiomi Yoshihisa, et al. "Glasgow-Blatchford Score Predicts Post-Discharge Gastrointestinal Bleeding in Hospitalized Patients with Heart Failure." Journal of Clinical Medicine 9, no. 12 (2020): 4083. http://dx.doi.org/10.3390/jcm9124083.

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Background: The Glasgow-Blatchford Score (GBS) is one of the most widely used scoring systems for predicting clinical outcomes for gastrointestinal bleeding (GIB). However, the clinical significance of the GBS in predicting GIB in patients with heart failure (HF) remains unclear. Methods and Results: We conducted a prospective observational study in which we collected the clinical data of a total of 2236 patients (1130 men, median 70 years old) who were admitted to Fukushima Medical University Hospital for acute decompensated HF. During the post-discharge follow-up period of a median of 1235 d

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Naqvi, Kiran, Maria Tanaka, Guillermo Garcia-Manero, Sherry Pierce, Hagop M. Kantarjian, and Srdan Verstovsek. "Patients' Comorbidities and Overall Survival in Primary Myelofibrosis (PMF)." Blood 118, no. 21 (2011): 5164. http://dx.doi.org/10.1182/blood.v118.21.5164.5164.

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Abstract Abstract 5164 Background: Cancer patients often experience comorbidities that may affect their therapeutic options, outcome of therapy, and their prognosis. However, none of the prognostic scoring systems for PMF account for an impact, if any, of patients' comorbidities on their prognosis. The aim of this study was to determine the effect of comorbidities on the survival of patients (pts) with PMF. Methods: We reviewed the medical records of 349 consecutive PMF pts who presented to our institution from 2000 to 2008. The Adult Comorbidity Evaluation-27 (ACE-27) form, a validated 27-ite

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White, Benjamin Easton, Maralyn R. Druce, Simona Grozinsky-Glasberg, et al. "Health-related quality of life in neuroendocrine neoplasia: a critical review." Endocrine-Related Cancer 27, no. 7 (2020): R267—R280. http://dx.doi.org/10.1530/erc-20-0066.

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Incidence of neuroendocrine neoplasia (NEN) is increasing, as is use of health-related quality of life (HRQoL) measurement in clinical trials. Following development of validated questionnaires, HRQoL is widely used to assess outcomes. This review is intended for healthcare professionals and is based on a selection of data published in the last decade. HRQoL is on par with other clinical endpoints such as performance status. Assessments in clinical trials have been particularly useful for monitoring the symptom burden of NEN, for the effects of treatments on patients’ lives, and have provided n

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Hertel, Nadine, Hartmut Merz, Heinz-Wolfram Bernd, et al. "Performance of international prognostic indices in plasmablastic lymphoma: a comparative evaluation." Journal of Cancer Research and Clinical Oncology 147, no. 10 (2021): 3043–50. http://dx.doi.org/10.1007/s00432-021-03580-z.

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Abstract Purpose Plasmablastic lymphoma (PBL) is a rare and aggressive B-cell malignancy with a heterogenous clinical and prognostic spectrum, determined by multiple factors, including age, HIV- and MYC-status. While there exist several validated scoring systems for diffuse large B-cell lymphoma, which incorporate basic clinical features (age, lactate dehydrogenase, sites of (extranodal) involvement, stage and performance), none of these have been systematically assessed in PBL. Methods We determined the (age-adjusted; aa)-International Prognostic Index (IPI), revised IPI (R-IPI), and National

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Tefferi, Ayalew, Paola Guglielmelli, Christy Finke, et al. "Integration of Mutations and Karyotype Towards a Genetics-Based Prognostic Scoring System (GPSS) for Primary Myelofibrosis." Blood 124, no. 21 (2014): 406. http://dx.doi.org/10.1182/blood.v124.21.406.406.

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Abstract Background : Current prognostication in primary myelofibrosis (PMF) utilizes international prognostic scoring systems that rely on clinical parameters that are sensitive to day-to-day variations and subjective interpretation. Recent studies in PMF have disclosed important prognostic information attached to additional cytogenetic details (Blood. 2011;118:4595) and somatic mutations, including CALR and ASXL1 (NEJM. 2013;369:2379; Leukemia. 2013;27:1861). Methods : PMF diagnosis and definition of blast transformation (BT) were according to World Health Organization criteria (Blood. 2009;

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Dybko, Jaroslaw, Olga Haus, Bozena Jazwiec, Tomasz Lonc, Mateusz Sawicki, and Kazimierz Kuliczkowski. "Hasford Score Is Correlated with 18 Month Molecular Response for Chronic Myeloid Leukemia Patients Treated with Second Generation Tyrosine Kinase Inhibitors and It May be Useful to Differentiate Low and Intermediate Risk Patients: A Single Institution Experience." Blood 126, no. 23 (2015): 5163. http://dx.doi.org/10.1182/blood.v126.23.5163.5163.

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Abstract BACKGROUND: Chronic myeloid leukemia (CML) has been a model disease for a variety of studies concerning scoring systems, graft versus leukemia effect or tyrosine kinase inhibitors (TKI) treatment for many years. Scoring systems playing an important role in modern medicine to establish risk-adjusted optimal therapy [1] have been always essential for CML changing treatment modalities [1-3]. The three principal risk scores : Sokal [2], Hasford [1] and European Treatment and Outcome Study (EUTOS) [3] were established in different eras of CML therapy with implications for prognosis and dis

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Revesz, E., C. M. Zalles, D. Ivancic, et al. "Relationship of recent pregnancy and cytologic atypia in the contralateral breast of patients with breast cancer." Journal of Clinical Oncology 29, no. 27_suppl (2011): 149. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.149.

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149 Background: Although early parity protects against breast cancer later in life, it is a risk factor in the years following pregnancy, particularly when child-bearing is delayed. In a separate study, we have reported that these pregnancy-associated breast cancers (PABC) are more likely to be hormone receptor (HR) negative; we have previously found that random fine needle aspiration (rFNA) of the contralateral breast (CB) frequently have atypia in women with HR negative breast cancer. We now report an analysis of the cytological features of contralateral rFNA in relation to recent parity, wi

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Vagney, Marie, Loic Desquilbet, Edouard Reyes-Gomez, et al. "Survival times for cats with hyperthyroidism treated with a 3.35 mCi iodine-131 dose: a retrospective study of 96 cases." Journal of Feline Medicine and Surgery 20, no. 6 (2017): 528–34. http://dx.doi.org/10.1177/1098612x17718416.

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Objectives Radioiodine (131I) dose determination using radiotracer kinetic studies or scoring systems, and fixed relatively high 131I dose (ie, 4 or 5 mCi) administration, are effective and associated with prolonged survival times for hyperthyroid cats. The latter method is less complicated but could expose patients and veterinary personnel to unnecessary levels of radiation. The aim of this study was to retrospectively evaluate the efficacy of a fixed 3.35 mCi 131I dose for the treatment of 96 hyperthyroid cats with no length estimation for any palpated goitre ⩾20 mm, assess outcome and ident

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Kuendgen, Andrea, Heinz Tuechler, Meritxell Nomdedeu, et al. "An Analysis of Prognostic Markers and the Performance of Scoring Systems in 1837 Patients with Therapy-Related Myelodysplastic Syndrome - a Study of the International Working Group (IWG-PM) for Myelodysplastic Syndromes (MDS)." Blood 126, no. 23 (2015): 609. http://dx.doi.org/10.1182/blood.v126.23.609.609.

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Abstract Background: The International Prognostic Scoring System (IPSS) for MDS has recently been revised (IPSS-R). However both scoring systems were developed after exclusion of therapy-related cases and data on its usefulness in treatment-related MDS (tMDS) is limited. Aims and Methods: We analyzed 1837 pts from Spanish, German, Swiss, Austrian, US, Italian, and Dutch centers diagnosed 1975-2015. Complete data to calculate the IPSS/-R was available in 1511 pts. The impact of prognostic features was analyzed by uni- and multivariable models and estimated by a measure of concordance for censor

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Schallmo, Michael S., Thomas H. Fitzpatrick, Hunter B. Yancey, Alejandro Marquez-Lara, T. David Luo, and Allston J. Stubbs. "Return-to-Play and Performance Outcomes of Professional Athletes in North America After Hip Arthroscopy From 1999 to 2016." American Journal of Sports Medicine 46, no. 8 (2018): 1959–69. http://dx.doi.org/10.1177/0363546518773080.

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Background: The effect of hip arthroscopy on athletic performance compared with preinjury levels for professional athletes in different sports remains unknown. In addition, while return rates have been reported for professional baseball, football, and hockey players, return rates have not been reported for professional basketball players. Hypothesis: Professional athletes in 4 major North American sports would be able to return to their sport and preoperative level of performance at a high rate after arthroscopic hip surgery. Study Design: Descriptive epidemiology study. Methods: Major League

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Schapper, Catherine C., Terence Dwyer, Geoffrey W. Tregear, MaryAnne Aitken, and Moira A. Clay. "Research performance evaluation: the experience of an independent medical research institute." Australian Health Review 36, no. 2 (2012): 218. http://dx.doi.org/10.1071/ah11057.

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Background. Evaluation of the social and economic outcomes of health research funding is an area of intense interest and debate. Typically, approaches have sought to assess the impact of research funding by medical charities or regional government bodies. Independent research institutes have a similar need for accountability in investment decisions but have different objectives and funding, thus the existing approaches are not appropriate. Methods. An evaluation methodology using eight indicators was developed to assess research performance across three broad categories: knowledge creation; in

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Mubiru, Frank, Barbara Castelnuovo, Steven J. Reynolds, et al. "Comparison of different cardiovascular risk tools used in HIV patient cohorts in sub-Saharan Africa; do we need to include laboratory tests?" PLOS ONE 16, no. 1 (2021): e0243552. http://dx.doi.org/10.1371/journal.pone.0243552.

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Introduction Cardiovascular disease (CVD) is the leading cause of death globally, representing 31% of all global deaths. HIV and long term anti-retroviral therapy (ART) are risk factors for development of CVD in populations of people living with HIV (PLHIV). CVD risk assessment tools are currently being applied to SSA populations, but there are questions about accuracy as well as implementation challenges of these tools in lower resource setting populations. We aimed to assess the level of agreement between the various cardiovascular screening tools (Data collection on Adverse effects of anti-

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Bui, Huu Phu, The Anh Nguyen, Thien Binh Nguyen, and Quang Dung Nguyen. "A Novel Mechanical Design of Automatic Laser Target-Scoring Systems." Key Engineering Materials 656-657 (July 2015): 589–93. http://dx.doi.org/10.4028/www.scientific.net/kem.656-657.589.

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This paper describes mechanical design of automatic target-scoring machine. Automatic target-scoring system use array of laser beams to define coordination of bullet through. The mechanical design accord to modular easy to installation, repairand upgrades. The system includes:emitter module, detector module, adjustment mechanism, andmechanical frame. All modules were design by CAD-CAM and machinedby CNC machines to high accuracy In additionfor accuracy using adjustment mechanisms to adjust modules.

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Keita-Perse, Olivia, and Robert P. Gaynes. "Severity of illness scoring systems to adjust nosocomial infection rates: A review and commentary." American Journal of Infection Control 24, no. 6 (1996): 429–34. http://dx.doi.org/10.1016/s0196-6553(96)90036-x.

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Gordon, Max J., Michael C. Churnetski, Hamood Alqahtani, et al. "Impact of Individual Comorbidities on Treatment Outcomes in Chronic Lymphocytic Leukemia." Blood 132, Supplement 1 (2018): 4848. http://dx.doi.org/10.1182/blood-2018-99-113917.

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Abstract Introduction: Chronic lymphocytic leukemia (CLL) is a common leukemia which tends to occur late in life. Comorbidities are common, and the iwCLL guidelines recommend their assessment in patients (pts) enrolled on clinical trials. The Cumulative Illness Rating Scale (CIRS) is a rigorous tool designed to evaluate the burden of comorbidities, which has been employed in therapeutic studies. Our group and others demonstrated that CIRS score predicts survival in pts with CLL treated with either chemo-immunotherapy (CIT) or novel kinase inhibitors (KI; ibrutinib) (Manda et al, 2016 & Gor

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Hagemeister, F. B. B., Anne Jacobson, Jeffrey D. Carter, and Tamar Sapir. "Real-World Gaps in Chart Documentation and Patient-Centered Care Inform Team-Based Action Plans for Relapsed/Refractory DLBCL: Results from a Quality Improvement Study." Blood 136, Supplement 1 (2020): 21–22. http://dx.doi.org/10.1182/blood-2020-136736.

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Background Using shared decision-making (SDM) to define therapeutic goals and shape individualized treatment plans for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) can profoundly improve patient-reported outcomes. However, unique barriers within oncology systems can impede patient-centered care coordination and delivery. In this quality improvement (QI) initiative, we assessed barriers to patient-centered R/R DLBCL care in 2 community oncology systems and conducted team-based audit-feedback (AF) sessions within each system to facilitate improved care coordination. Methods Betw

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Kuendgen, Andrea, Jenny Seidler, Michael Lauseker, et al. "Prognostic Impact Of Molecular Mutations In 182 Patients With Myelodysplastic Syndromes." Blood 122, no. 21 (2013): 2758. http://dx.doi.org/10.1182/blood.v122.21.2758.2758.

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Abstract Introduction Myelodysplastic syndromes (MDS) are heterogeneous regarding clinical characteristics, as well as prognosis and treatment approaches. Therapeutic decision making relies greatly on prognostic scoring systems. Recently, the gold-standard IPSS (International prognostic scoring system [Greenberg Blood 1997]) has been revised. The new IPSS-R still uses cell counts, marrow blast count, and karyotypic abnormalities to stratify patients (pts) into risk groups [Greenberg Blood 2012]. However, more than 50% of all MDS pts present with a normal karyotype and even in pts with identica

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Sochacki, Andrew, Cosmin Adrian Bejan, Shilin Zhao, et al. "Patient Specific Comorbidities Impact Overall Survival in Myelofibrosis." Blood 134, Supplement_1 (2019): 2959. http://dx.doi.org/10.1182/blood-2019-121513.

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Background:Treatment decisions in primary myelofibrosis (PMF) are guided by several prognostic systems based on disease-specific risk factors, including complete blood counts and cytogenetics. Patient specific comorbidities, e.g. non-hematopoietic organ dysfunction, are not incorporated into current prognostic models. Likewise, PMF risk stratification has not yet integrated large scale electronic health record (EHR) clinical data to refine these scoring systems. We have identified a PMF cohort within the Synthetic Derivative (SD), a de-identified, research-dedicated mirror of the EHR at Vander

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Singh, Sunny R. K., Sindhu Malapati, Rohit Kumar, Olekdandra Lupak, and Philip Kuriakose. "Predictors of Transfer to Different Facility at Discharge in Patients Admitted with Hematologic Malignancy: A Nationwide Inpatient Sample (NIS) Database Analysis." Blood 134, Supplement_1 (2019): 2132. http://dx.doi.org/10.1182/blood-2019-127604.

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Background: Improvement in cancer treatment has led to an increase in prevalence of hematological malignancies with a rise in healthcare utilization secondary to this. We aim to identify predictive factors for transfer to another non-acute facility (including nursing home, subacute rehab and other institutional care) at the time of discharge. Methods: This is a retrospective cohort analysis of NIS database from 2014. Inclusion criteria was any admission of adults (≥18 years) with hematological malignancy (identified by ICD-9-CM diagnosis codes). We identified subgroups of hematological maligna

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Nakane, Takahiko, Mika Nakamae, Hideo Koh, et al. "Pre-Transplant Autonomic Nervous System Malfunction Is a Powerful Predictor for Survival after Allogeneic Hematopoietic Cell Transplantation." Blood 126, no. 23 (2015): 3205. http://dx.doi.org/10.1182/blood.v126.23.3205.3205.

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Abstract Background: Autonomic nerve function can be affected by various factors such as patient activity of daily living, disease status, treatment history and/or comorbidity. Indeed, autonomic nervous system dysfunction, as indexed by heart rate variability (HRV), has shown prognostic value for various disease outcomes, but its influence on outcomes following allogeneic hematopoietic cell transplantation (allo-HCT) is unclear. We therefore conducted a prospective observational study to determine the impact of autonomic nervous system dysfunction on outcomes following allo-HCT. Methods: From

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Bories, Pierre, Sébastien Lamy, Celestine Simand, et al. "Impact of Non Professional Physicians' Characteristics on Medical Decision Making in Older Patients with Acute Myeloid Leukemia." Blood 128, no. 22 (2016): 3576. http://dx.doi.org/10.1182/blood.v128.22.3576.3576.

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Abstract Frontline therapy for newly diagnosed AML in older adults can be classified as "more" or "less" intensive. Assignment of patients (pts) to intensive chemotherapy (ICT) or low-intensity therapy (LIT) such as hypomethylating agents (HMA), low-dose aracytine (LDAC) or best supportive care (BSC), should be based on patient- and disease-related prognosis factors. Although scoring systems have been proposed to rationalize this clinical decision-making, there is a strong heterogeneity in clinical practice. Cancer management study mainly focused on patients' determinants of care but very few

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Guirguis, Hany R. Y., Mervat Mahrous, Matthew Cheung, Liying Zhang, and Rena Buckstein. "Central Nervous System (CNS) Prophylaxis Does Not Decrease the Rates of CNS Relapse From Diffuse Large B-Cell Lymphoma In the Era of R-CHOP." Blood 116, no. 21 (2010): 4161. http://dx.doi.org/10.1182/blood.v116.21.4161.4161.

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Abstract Abstract 4161 Background: While some clinical characteristics/sites of diffuse large B-cell lymphoma (DLBCL) are associated with increased rates of central nervous system (CNS) relapse, the role/benefits of CNS prophylaxis are controversial, particularly in the era of better disease control with R-CHOP chemotherapy. We evaluated the benefits of high dose methotrexate (HDMTX 3 g/m2) and intrathecal (IT) chemotherapy (MTX 12 mg) as primary CNS prophylaxis (CNSPr) in patients with DLBCL (de novo or transformed) treated with curative intent R-CHOP chemotherapy between the years of January

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Cai, YuFan, YanYan Zhang, and ChengSheng Pan. "Lane Detection Based on Adaptive Network of Receptive Field." Security and Communication Networks 2021 (March 24, 2021): 1–13. http://dx.doi.org/10.1155/2021/6618459.

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The difficulty of lane detection lies in the imbalance of the number of target pixels and background pixels. The sparse target distribution misleads the neural network to pay more attention to background segmentation in order to obtain a better loss convergence result. This makes it difficult for some models to detect lane line pixels and leads to the training fail (unable to output useful lane information). Increasing receptive field properly can enlarge the sphere of action between pixels, so as to restrain this trouble. Moreover, the interference information and noise existing in the real e

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Fann, Jean-Christophe, and Jasenka Rakas. "Methodology for Environmental Sustainability Evaluation Of Airport Development Alternatives." International Journal of Applied Logistics 4, no. 4 (2013): 8–31. http://dx.doi.org/10.4018/ijal.2013100102.

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This study develops a new approach for the evaluation of greener airport systems. The proposed concepts demonstrate how to implement greener practices from the early stages of an airport infrastructure project in an economically rational and stakeholder-focused manner. Objectives of the proposed methodology are two-fold: (1) to promote greener design practices among airport planners, designers, and managers, and (2) to institute active communication among all airport stakeholders. The study contributes to the state of the knowledge in airport environmental management by proposing the combinati

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