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Journal articles on the topic 'Adjuvant de Freund'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Near, Karen A., Anthony W. Stowers, Dragana Jankovic, and David C. Kaslow. "Improved Immunogenicity and Efficacy of the Recombinant 19-Kilodalton Merozoite Surface Protein 1 by the Addition of Oligodeoxynucleotide and Aluminum Hydroxide Gel in a Murine Malaria Vaccine Model." Infection and Immunity 70, no. 2 (2002): 692–701. http://dx.doi.org/10.1128/iai.70.2.692-701.2002.

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ABSTRACT Vaccination of mice with yeast-secreted Plasmodium yoelii-derived 19-kilodalton merozoite surface protein 1 (yMSP119) has been shown to afford protection from challenge with a lethal strain of P. yoelii. Sterile immunity can be achieved when MSP119 is emulsified in Freund adjuvant but not when it is adsorbed to aluminum hydroxide gel (alum). Because complete Freund adjuvant is not an acceptable adjuvant for use in humans, alternative adjuvants must be identified for formulating MSP119 as a vaccine for use in humans. To determine whether oligodeoxynucleotides with CpG motifs (ODN), rep

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Gaspar, Michael P., Genevieve Landes, Farinaz Safavi, and A. Lee Osterman. "Accidental Injection of Freund Complete Adjuvant With Mycobacterium Tuberculosis." Journal of Hand Surgery 43, no. 9 (2018): 873.e1–873.e4. http://dx.doi.org/10.1016/j.jhsa.2018.02.008.

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Foss, Dennis L., and Michael P. Murtaugh. "Mechanisms of vaccine adjuvanticity at mucosal surfaces." Animal Health Research Reviews 1, no. 1 (2000): 3–24. http://dx.doi.org/10.1017/s1466252300000025.

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AbstractThe vast majority of pathogens invade via mucosal surfaces, including those of the intestine. Vaccination directly on these surfaces may induce local protective immunity and prevent infection and disease. Although vaccine delivery to the gut mucosa is fraught with obstacles, immunization can be enhanced using adjuvants with properties specific to intestinal immunity. In this review, we present three general mechanisms of vaccine adjuvant function as originally described by Freund, and we discuss these principles with respect to intestinal adjuvants in general and to the prototypical mu

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Kumar, Vikas, F. A. Al-Abbasi, Amita Verma, Mohd Mujeeb та Firoz Anwar. "Umbelliferone β-d-galactopyranoside exerts an anti-inflammatory effect by attenuating COX-1 and COX-2". Toxicology Research 4, № 4 (2015): 1072–84. http://dx.doi.org/10.1039/c5tx00095e.

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Umbelliferone β-d-galactopyranoside (UFG) is a coumarin found in many plants. This study examines the anti-inflammatory potential of UFG on chronic inflammation induced by Complete Freund Adjuvant (CFA) in experimental rats.

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Shakya, Akhilesh Kumar, Ashok Kumar, and Kutty Selva Nandakumar. "Adjuvant properties of a biocompatible thermo-responsive polymer of N -isopropylacrylamide in autoimmunity and arthritis." Journal of The Royal Society Interface 8, no. 65 (2011): 1748–59. http://dx.doi.org/10.1098/rsif.2011.0114.

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To evaluate the thermo-responsive poly( N -isopropylacrylamide) (PNiPAAm) polymer as an adjuvant, we synthesized PNiPAAm through free radical polymerization and characterized it both in vitro and in vivo . The polymer when mixed with collagen type II (CII) induced antigen-specific autoimmunity and arthritis. Mice immunized with PNiPAAm–CII developed significant levels of CII-specific IgG response comprising major IgG subclasses. Antigen-specific cellular recall response was also enhanced in these mice, while negligible level of IFN-γ was detected in splenocyte cultures, in vitro . PNiPAAm–CII-

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STRASSBURGER, D., Y. IRLIN, H. CARP, et al. "Immune Features in Complete Freund Adjuvant-Treated CBA/J Mouse Model." American Journal of Reproductive Immunology 28, no. 3-4 (1992): 277–80. http://dx.doi.org/10.1111/j.1600-0897.1992.tb00814.x.

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7

Carpentier, A. F., T. Tran, F. Sejalon, et al. "The adjuvant effect of melanin is superior to Incomplete Freund adjuvant in a tumor subunit vaccine model." European Journal of Cancer 92 (March 2018): S2—S3. http://dx.doi.org/10.1016/j.ejca.2018.01.008.

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8

van Ommen, R., A. E. C. M. Vredendaal, M. de Gooyer, A. van Oudenaren та H. F. J. Savelkoul. "The Effect of IFN-γ, Alum and Complete Freund Adjuvant on TNP-KLH Induced Ig.G1, IgE and IgG2aResponses in Mice". Mediators of Inflammation 3, № 5 (1994): 387–92. http://dx.doi.org/10.1155/s0962935194000542.

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Adjuvants are considered to play an important role in directing the isotype and amount of antibodies produced upon immunization by conducting the development of either Th-1 or Th-2 cells upon T-cell stimulation. This is based on the different cytokine production patterns that were observed afterin vitroresttmulation of T cells isolated from mice immunized with antigen either adsorbed on alum or emulsified in complete Freund adjuvant (CFA). However, other studies suggest that primarily the type of antigen determines which isotypes are produced and to what extent. In these studies, however, IgE

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Stanislas-Leguern, Giséle, Roland Masse, Francis Jaubert, Jacques Chretien, and Gerard Huchon. "Pulmonary Gallium Uptake in Rats with Granulomatosis Induced by Complete Freund Adjuvant." Experimental Lung Research 14, no. 4 (1988): 445–58. http://dx.doi.org/10.3109/01902148809087820.

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10

Rajkapoor, B., V. Ravichandran ., M. Gobinath ., et al. "Effect of Bauhinia variegata on Complete Freund`s Adjuvant Induced Arthritis in Rats." Journal of Pharmacology and Toxicology 2, no. 5 (2007): 465–72. http://dx.doi.org/10.3923/jpt.2007.465.472.

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11

Lim, Sai-Kiang. "Freund adjuvant induces TLR2 but not TLR4 expression in the liver of mice." International Immunopharmacology 3, no. 1 (2003): 115–18. http://dx.doi.org/10.1016/s1567-5769(02)00256-4.

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12

Vigl, Benjamin, David Aebischer, Maximilian Nitschké, et al. "Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner." Blood 118, no. 1 (2011): 205–15. http://dx.doi.org/10.1182/blood-2010-12-326447.

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Abstract Chemokines and adhesion molecules up-regulated in lymphatic endothelial cells (LECs) during tissue inflammation are thought to enhance dendritic cell (DC) migration to draining lymph nodes, but the in vivo control of this process is not well understood. We performed a transcriptional profiling analysis of LECs isolated from murine skin and found that inflammation induced by a contact hypersensitivity (CHS) response up-regulated the adhesion molecules ICAM-1 and VCAM-1 and inflammatory chemokines. Importantly, the lymphatic markers Prox-1, VEGFR3, and LYVE-1 were significantly down-reg

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Соколовский, N. Sokolovskiy, Козырев, et al. "Comparative Analysis of the Acyzol Effects in the Prevention of Models of Amyloidosis." Journal of New Medical Technologies 22, no. 2 (2015): 50–55. http://dx.doi.org/10.12737/11831.

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First, the authors obtained two models of the system cardiopatic amyloidosis in rats. The first model was created by a single injection of equal mixture of native egg albumin and Freund&#180;s complete adjuvant 0.2 ml per five points of injection (subcutaneously in the axillary and inguinal region, left and right intraperitoneally). The second model was created with a single introduction of a mixture of native egg albumin (40%), Freund&#180;s complete adjuvant (40%), and myocardial homogenate of rats (20%) at a dose of 0.2 ml in a similar five-point-injection. To prevent cardiac

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Wang, Zibing, Jing Jiang, Zhiguang Li, Jinhua Zhang, Hui Wang, and Zhihai Qin. "A Myeloid Cell Population Induced by Freund Adjuvant Suppresses T-cell−mediated Antitumor Immunity." Journal of Immunotherapy 33, no. 2 (2010): 167–77. http://dx.doi.org/10.1097/cji.0b013e3181bed2ba.

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Hutahaean, Salomo. "Synthetic Peptides as Immunogen in the Production of IgY Anti-C-Myc Antibody in Local Chicken (Gallus Gallus)." International Journal of Ecophysiology 1, no. 1 (2019): 34–39. http://dx.doi.org/10.32734/ijoep.v1i1.845.

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Experiments conducted to determine the effect of doses of immunogen on the levels of IgY c-Myc antibody in chickens. To generate antibody, we used a synthetic peptide as an immunogen, which is developed from the epitope of the c-Myc protein. Hens were immunized a week after their first eggs were produced. Antigen diluted in double distilled water and emulsified with Freund 's Complete Adjuvant. The suspension was injected into the area of the chicken breast subcutaneously with a dose of 0, 0.02, 0.04, 0.06, 0.08, 0.1, 0.12, 0.14, or 0.16 mg per hen. Booster injection performed on days 10, 20,

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Hutahaean, Salomo. "Synthetic Peptides as Immunogen in the Production of IgY Anti-C-Myc Antibody in Local Chicken (Gallus gallus)." International Journal of Ecophysiology 1, no. 2 (2019): 140–45. http://dx.doi.org/10.32734/ijoep.v1i2.1277.

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Experiments conducted to determine the effect of doses of immunogen on the levels of IgY c-Myc antibody in chickens. To generate antibody, we used a synthetic peptide as an immunogen, which is developed from the epitope of the c-Myc protein. Hens were immunized a week after their first eggs were produced. Antigen diluted in double distilled water and emulsified with Freund 's Complete Adjuvant. The suspension was injected into the area of the chicken breast subcutaneously with a dose of 0, 0.02, 0.04, 0.06, 0.08, 0.1, 0.12, 0.14, or 0.16 mg per hen. Booster injection performed on days 10, 20,

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Toder, V., D. Strassburger, Y. Irlin, et al. "Complete freund adjuvant reverses high fetal resorption rate in CBA/JX DBA/2J mouse combination." Journal of Reproductive Immunology 15 (July 1989): 124. http://dx.doi.org/10.1016/0165-0378(89)90258-1.

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18

Kumar, Akshay, Navneet Dhaliwal, Jatinder Dhaliwal, Ravinder Naik Dharavath, and Kanwaljit Chopra. "Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats." Pharmacological Reports 72, no. 1 (2019): 104–14. http://dx.doi.org/10.1007/s43440-019-00022-z.

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Clausse, Maria, Alejandra G. Díaz, Andrés E. Ibañez, Juliana Cassataro, Guillermo H. Giambartolomei, and Silvia M. Estein. "Evaluation of the Efficacy of Outer Membrane Protein 31 Vaccine Formulations for Protection against Brucella canis in BALB/c Mice." Clinical and Vaccine Immunology 21, no. 12 (2014): 1689–94. http://dx.doi.org/10.1128/cvi.00527-14.

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ABSTRACTCanine brucellosis is an infectious disease caused by the Gram-negative bacteriumBrucella canis. Unlike conventional control programs for other species of the genusBrucella, currently there is no vaccine available against canine brucellosis, and preventive measures are simply diagnosis and isolation of infected dogs. New approaches are therefore needed to develop an effective and safe immunization strategy against this zoonotic pathogen. In this study, BALB/c mice were subcutaneously immunized with the following: (i) the recombinantBrucellaOmp31 antigen formulated in different adjuvant

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Ohashi, Tatsuhiko, Suguru Matsui, Tomoji Yamada, et al. "THE EFFECT OF COMPLETE FREUND ADJUVANT ON THE DEVELOPMENT OF BLADDER TUMOR INDUCED BY N-BUTYL-N-(4-HYDROXYBUTYL) NITROSAMINE." Japanese Journal of Urology 79, no. 11 (1988): 1824–28. http://dx.doi.org/10.5980/jpnjurol1928.79.11_1824.

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21

Binder, Waltraud, Halina Machelska, Shaaban Mousa та ін. "Analgesic and Antiinflammatory Effects of Two Novel κ-Opioid Peptides". Anesthesiology 94, № 6 (2001): 1034–44. http://dx.doi.org/10.1097/00000542-200106000-00018.

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Background This study investigates two new kappa-agonist tetrapeptides, FE 200665 and FE 200666, with high peripheral selectivity as a result of poor central nervous system penetration. Methods Four days after administration of Freund adjuvant into the hind paw of male Wistar rats, antinociceptive effects of intraplantar and subcutaneous injection of FE 200665 and FE 200666 were measured by paw pressure algesiometry and compared with the kappa-agonist U-69,593. Peripheral and kappa-receptor selectivity was assessed by the antagonists naloxone methiodide (NLXM) and nor-binaltorphimine, respecti

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Obiri, DavidD, Joshua Oppong-Sarfo, Newman Osafo, and JudeK Prah. "Margaritaria discoidea (Euphorbiaceae) stem bark extract attenuates allergy and Freund′s adjuvant-induced arthritis in rodents." Pharmacognosy Research 6, no. 2 (2014): 163. http://dx.doi.org/10.4103/0974-8490.129039.

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23

Lima, Mariana Machado, Lorena Gimenes da Silva, Jailson Araújo Dantas, Ciomar Aparecida Bersani Amado, Miguel Spack Junior, and Jacqueline Nelisis Zanoni. "Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant." Acta Scientiarum. Biological Sciences 41, no. 1 (2019): 36978. http://dx.doi.org/10.4025/actascibiolsci.v41i1.36978.

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The aim the study was to evaluate the effects of autohemotransfusion in adjuvant-induced arthritis model by injections of high and low doses of Complete Freund´s Adjuvant (CFA). Male Holtzman rats (200-230g) were distributed in six groups: control (C); control treated by autohemotransfusion (CT); CFA induced arthritis 0.5% w/v (AIA); CFA induced arthritis 0.5% w/v treated with autohemotransfusion (AIAT); CFA induced arthritis 0.1% w/v (AS) and CFA induced arthritis 0.1% w/v treated with autohemotransfusion (AST). The number of leukocytes, the weight of different organs and the paw volume were

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Petchi, RRamesh, S. Parasuraman, C. Vijaya, SV Gopala Krishna, and MKiran Kumar. "Antiarthritic activity of a polyherbal formulation against Freund′s complete adjuvant induced arthritis in Female Wistar rats." Journal of Basic and Clinical Pharmacy 6, no. 3 (2015): 77. http://dx.doi.org/10.4103/0976-0105.160738.

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Lai, Cheng-Yuan, Tzer-Bin Lin, Ming-Chun Hsieh, Gin-Den Chen та Hsien-Yu Peng. "SIRPα1-SHP2 Interaction Regulates Complete Freund Adjuvant–Induced Inflammatory Pain via Src-Dependent GluN2B Phosphorylation in Rats". Anesthesia & Analgesia 122, № 3 (2016): 871–81. http://dx.doi.org/10.1213/ane.0000000000001116.

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Jagessar, S. Anwar, Yolanda S. Kap, Nicole Heijmans, et al. "Induction of Progressive Demyelinating Autoimmune Encephalomyelitis in Common Marmoset Monkeys Using MOG34-56Peptide in Incomplete Freund Adjuvant." Journal of Neuropathology & Experimental Neurology 69, no. 4 (2010): 372–85. http://dx.doi.org/10.1097/nen.0b013e3181d5d053.

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Omorogbe, Osarume, Abayomi M. Ajayi, Benneth Ben-Azu, et al. "Jobelyn® attenuates inflammatory responses and neurobehavioural deficits associated with complete Freund-adjuvant-induced arthritis in mice." Biomedicine & Pharmacotherapy 98 (February 2018): 585–93. http://dx.doi.org/10.1016/j.biopha.2017.12.098.

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Wu, Guofeng, Wenbo Nie, Qiu Wang та ін. "Umbelliferone Ameliorates Complete Freund Adjuvant–Induced Arthritis via Reduction of NF-κB Signaling Pathway in Osteoclast Differentiation". Inflammation 44, № 4 (2021): 1315–29. http://dx.doi.org/10.1007/s10753-021-01418-x.

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Calvino, B., J. Y. Couraud, and J. M. Besson. "Prevaccination with diluted freund adjuvant prevents the development of chronic pain and transient release of cerebrospinal fluid substance P in adjuvant-induced arthritis in rats." Pain 58, no. 2 (1994): 211–17. http://dx.doi.org/10.1016/0304-3959(94)90201-1.

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Иванова, Е. А., А. И. Матюшкин, and Т. А. Воронина. "Effect of different dosage regimens of a topical formulation of Hemantane on complete Freund`s adjuvant-induced nonspecific inflammation in rats." ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», no. 3() (September 16, 2020): 93–101. http://dx.doi.org/10.25557/0031-2991.2020.03.93-101.

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Цель исследования - оценка способности гимантана (N-(2-адамантил)-гексаметиленимина гидрохлорида) в наружной гелевой лекарственной форме ослаблять у крыс неспецифическую воспалительную реакцию, вызванную полным адъювантом Фрейнда (ПАФ). Методика. Воспалительный процесс моделировали субплантарным введением ПАФ в левую заднюю лапу аутбредных крыс. Оценивали степень отёчности лапы животных по изменению диаметра стопы и голеностопного сустава до и после введения ПАФ. Гимантан в виде 5% гелевой лекарственной формы и препарат сравнения диклофенак в виде 1% гелевой лекарственной формы наносили ежедне

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Darmawi, Darmawi, Ummu Balqis, Risa Tiuria, Muhammad Hambal, and Samadi Samadi. "Kajian Titer Antibodi Pada Yolk dari Ayam yang Diimunisasi Dengan Antigen Ekskretori/Sekretori Stadium L3 Ascaridia galli." Jurnal Agripet 8, no. 2 (2008): 21–26. http://dx.doi.org/10.17969/agripet.v8i2.611.

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Evaluation of antibody titre in yolk from immunized chickens with excretory/secretory antigen of L3 stage of Ascaridia galliABSTRACT. The purpose of the present study was to trigger humoral immunity of chickens egg yolk exposed to excretory/secretory released in vitro by L3 stage of Ascaridia galli. Amount of 6 head chickens were divided into two groups. First group, the chickens were not immunized. Second group, the chickens were immunized with excretory/ secretory. Active immunizations with excretory/ secretory antigen were applied intra muscularly of chickens with an initial dose of 80 μg.

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Strassburger, D., M. Pecht, Y. Irlin, et al. "Pregnancy loss in CBA/J X DBA/2J mouse combination. Immune profile of complete freund adjuvant-treated mothers." Journal of Reproductive Immunology 15 (July 1989): 121. http://dx.doi.org/10.1016/0165-0378(89)90252-0.

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Chis, Irina C., Doina Baltaru, Simona Clichici, Ovidiu Oniga, Ileana Cojocaru, and Cristina Nastasa. "The Effects of a 5-Chromene-yl-thiazolidin-2,4-dione Derivative in Alleviating Oxidative Stress in Adjuvant-Induced Arthritis." Revista de Chimie 69, no. 9 (2018): 2361–65. http://dx.doi.org/10.37358/rc.18.9.6534.

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Rheumatoid arthritis (RA) is a chronic inflammatory disease that reduces life quality and requires long-life therapy. Quercetin (Que) is a natural flavonoid with antioxidant and anti-inflammatory effects. (3-(2-(4-Chlorophenyl)-2-oxoethyl)-5-((6-methyl-4-oxo-4H-chromen-3-yl)methylene) thiazolidine-2,4-dione (TZD) is a thiazolidinedione derivative synthesized in our laboratory. This study was designed to investigate the antioxidant effects of the Que and TZD derivative administration in adjuvant-induced arthritic (AIA) rats. AIA was induced in Wistar rats by the intraplantar injection of Freund

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Pohanka, M., I. Vobornikova, and J. Fusek. "Freund´s complete adjuvant effect on BALB/c mice: an insight into inflammation and oxidative stress after immunity challenge." Bratislava Medical Journal 117, no. 05 (2016): 268–71. http://dx.doi.org/10.4149/bll_2016_052.

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KLINGSTROM, J. "Vaccination of C57/BL6 mice with Dobrava hantavirus nucleocapsid protein in Freund?s adjuvant induced partial protection against challenge." Vaccine 22, no. 29-30 (2004): 4029–34. http://dx.doi.org/10.1016/j.vaccine.2004.03.045.

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TODER, V., D. STRASSBURGER, Y. IRLIN, H. CARP, M. PECHT, and N. TRAININ. "Nonspecific Immunopotentiators and Pregnancy Loss: Complete Freund Adjuvant Reverses High Fetal Resorption Rate in CBA × DBA/2 Mouse Combination." American Journal of Reproductive Immunology 24, no. 3 (1990): 63–66. http://dx.doi.org/10.1111/j.1600-0897.1990.tb01040.x.

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Saccol, Renata da Silva Pereira, Karine Lanes Silveira, Stephen Adeniyi Adefegha, et al. "Effect of quercetin on E‐NTPDase / E‐ADA activities and cytokine secretion of complete Freund adjuvant–induced arthritic rats." Cell Biochemistry and Function 37, no. 7 (2019): 474–85. http://dx.doi.org/10.1002/cbf.3413.

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Ratheesh, M., Jose P. Svenia, Saji Sangeeth, et al. "Antioxidant, Anti-inflammatory, and Anti-arthritic Effect of Thymoquinone-rich Black Cumin (Nigella sativa) oil (BlaQmax®) on Adjuvant-induced Arthritis." Journal of Food Research 10, no. 1 (2021): 52. http://dx.doi.org/10.5539/jfr.v10n1p52.

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Rheumatoid Arthritis (RA) is a complex autoimmune disorder involving chronic and persistent inflammation, principally influencing the synovial joints which further prompting the obliteration of articular cartilage. Although black cumin (Nigella sativa) oil has already studied for its anti-arthritic properties, the current study was focused on the comparative evaluation of the antioxidant and anti-inflammatory properties of a thymoquinone (TQ)-rich (5% w/v) black cumin oil (BQ) with the commonly available standard black cumin oil (BM) containing 0.4% (w/v) TQ, and subsequent investigation on th

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Maslovaric, Irina, Natasa Vukov, Aleksandra Stojkovic, Dejana Kosanovic, and Katica Jovanova-Nesic. "Morphological changes in lymph nodes and spleen upon EAE induction in C57BL/6 mic." Archives of Biological Sciences 65, no. 4 (2013): 1317–22. http://dx.doi.org/10.2298/abs1304317m.

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Myelin oligodendrocyte glycoprotein (MOG) is a protein widely used in the induction of experimental autoimmune encephalomyelitis (EAE) for studying human multiple sclerosis (MS). In C57BL/6 female mice aged eight weeks, we administered subcutaneously MOG35-55 peptide in CFA (complete Freund?s adjuvant) along with pertussis vaccine injected intraperitoneally. We observed the sign of flaccid tail as early as thirteen days post-immunization in five of twelve animals. Hematoxylin and eosin staining of paraffin-embedded sections of lymph nodes and spleen revealed the presence of germinal centers in

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Maletto, Belkys A., Andrea S. Ropolo, Diego O. Alignani, et al. "Presence of neutrophil-bearing antigen in lymphoid organs of immune mice." Blood 108, no. 9 (2006): 3094–102. http://dx.doi.org/10.1182/blood-2006-04-016659.

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Abstract Neutrophils play a crucial early role during the innate response, but little is known about their possible contribution when an adaptive immune response is installed. A robust neutrophilia and a T helper 1 (Th1) immune response are present after immunization with Complete Freund Adjuvant (CFA). We show that when FITC-labeled OVA was injected into the footpad of OVA/CFA immunized mice, the main OVA-FITC+ cells recruited in draining popliteal lymph nodes (LNs) were neutrophils, with most of them arriving at the LN by means of lymphatic vessels. The development of this OVA-FITC+ neutroph

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Darmawi, Darmawi, Ummu Balqis, Risa Tiuria, Muhammad Hambal, and Samadi Samadi. "Purifikasi Imunoglobulin Yolk Pada Ayam yang Divaksin terhadap Ekskretori/Sekretori Stadium L3 Ascaridia galli." Jurnal Agripet 10, no. 2 (2010): 9–15. http://dx.doi.org/10.17969/agripet.v10i2.638.

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Purification yolk immunoglobulin of hens vaccinated against excretory/secretory Ascaridia galli L3 larvae stageABSTRACT. The main immunoglobulin fraction of poultry is called IgY, in order to distinguish it from the mammalian IgG. This article focus on purification yolk immunoglobulin of hens vaccinated against excretory/secretory Ascaridia galli larvae to obtained purity IgY. Active vaccinations with excretory/secretory antigen were applied intra muscularly of chickens with an initial dose of 80 μg. The vaccinations were repeated three times with dose of each 60 μg with an interval of one wee

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Trott, D. L., E. M. Hellestad, M. Yang, and M. E. Cook. "Additions of Killed Whole Cell Bacteria Preparations to Freund Complete Adjuvant Alter Laying Hen Antibody Response to Soluble Protein Antigen." Poultry Science 87, no. 5 (2008): 912–17. http://dx.doi.org/10.3382/ps.2007-00481.

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SZEKERES-BARTHO, JULIA, R. KINSKY, M. KAPOVIC, and G. CHAOUAT. "Complete Freund Adjuvant Treatment of Pregnant Females Influences Resorption Rates in CBA/J × DBA/2 Matings via Progesterone-Mediated Immunomodulation." American Journal of Reproductive Immunology 26, no. 2 (1991): 82–83. http://dx.doi.org/10.1111/j.1600-0897.1991.tb00976.x.

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Rodrigues, David Henrique, Daniela Sachs, and Antonio Lucio Teixeira. "Mechanical hypernociception in experimental autoimmune encephalomyelitis." Arquivos de Neuro-Psiquiatria 67, no. 1 (2009): 78–81. http://dx.doi.org/10.1590/s0004-282x2009000100019.

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BACKGROUND: Pain is an important clinical manifestation in multiple sclerosis (MS) patients, though it has been neglected in clinical and experimental researches. OBJECTIVE: To investigate the nociceptive response in MOG35-55 experimental autoimmune encephalomyelitis (EAE)-induced mice. METHOD: EAE was induced in 8 to 10 week old C57BL/6 female mice with an emulsion of MOG35-55, Complete Freund Adjuvant, Mycobacterium tuberculosis H37 RA and pertussis toxin. Nociception was evaluated by the von Frey filaments method. A clinical scale ranging from 0 to 15 was used to assess motor impairment. RE

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Fatimah, Siti, Agustin Indrawati, and Angela Mariana Lusiastuti. "TOKSISITAS DAN IMUNOGENISITAS PRODUK EKSTRASELULER Mycobacterium fortuitum PADA IKAN GURAME (Osphronemus gouramy)." Jurnal Riset Akuakultur 10, no. 2 (2015): 231. http://dx.doi.org/10.15578/jra.10.2.2015.231-241.

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Mycobacterium fortuitum merupakan bakteri patogen dengan kejadian penyakit bersifat kronis. Penelitian ini bertujuan untuk mengevaluasi tingkat toksisitas dan imunogenisitas produk ekstraseluler M. fortuitum pada ikan gurame. Pengujian toksisitas dilakukan pada ikan dengan bobot 15 g yang diinjeksi secara intraperitoneal (i.p) dengan konsentrasi ECP berbeda yaitu 7,15 μg/ikan; 14,3 μg/ikan; 28,6 μg/ikan; 57,2 μg/ikan; sedangkan kontrol dengan menggunakan PBS. Pengujian imunogenisitas dilakukan dengan menggunakan ikan seberat 25-30 g. Ikan dibagi dalam tiga perlakuan yaitu: ECP dengan Freund In

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Beauvillain, Céline, Pierre Cunin, Andrea Doni, et al. "CCR7 is involved in the migration of neutrophils to lymph nodes." Blood 117, no. 4 (2011): 1196–204. http://dx.doi.org/10.1182/blood-2009-11-254490.

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Abstract Increasing evidence suggests that neutrophils may participate in the regulation of adaptive immune responses, and can reach draining lymph nodes and cross-prime naive T cells. The aim of this study was to identify the mechanism(s) involved in the migration of neutrophils to the draining lymph nodes. We demonstrate that a subpopulation of human and mouse neutrophils express CCR7. CCR7 is rapidly expressed at the membrane upon stimulation. In vitro, stimulated human neutrophils migrate in response to the CCR7 ligands CCL19 and CCL21. In vivo, injection of complete Freund adjuvant induce

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Bertaim, Thierry, Eric Chapuy, François Caussade, and Denis Ardid. "Dose and Administration Schedule Effect of Tiludronate on Joint Damage in the Model of Complete Freund Adjuvant Induced Monoarthritis in Rats." Open Journal of Rheumatology and Autoimmune Diseases 03, no. 01 (2013): 18–25. http://dx.doi.org/10.4236/ojra.2013.31004.

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Eggadi, Venkateshwarlu, Girija Pashikanti, Umasankar Kulundaivelu, VenkateshwarRao Jupalli, and Sharvana BhavaBandaru Sheshagiri. "Anti-arthritic activity of ethanolic extract from the leaves of Commiphora caudata (Linn.) in complete Freund′s adjuvant-induced arthritic rats." Nigerian Journal of Experimental and Clinical Biosciences 2, no. 1 (2014): 42. http://dx.doi.org/10.4103/2348-0149.135729.

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Goyal, Swapnil, NavinR Sheth, and DN Srivastava. "Systemic administration of fractions from Nyctanthes arbor-tristis attenuates chronic inflammatory response in Freund′s-complete-adjuvant-induced arthritis in rats." International Journal of Green Pharmacy 8, no. 3 (2014): 147. http://dx.doi.org/10.4103/0973-8258.140168.

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Ruknuddin, Galib, BJ Patgiri, PK Prajapati, BK Ashok, and B. Ravishankar. "Anti-arthritic activity of Dashanga Ghana (an ayurvedic compound formulation) against Freund′s adjuvant induced arthritis in Charles Foster albino rats." Toxicology International 22, no. 1 (2015): 141. http://dx.doi.org/10.4103/0971-6580.172279.

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