Relevant bibliographies by topics / ADME (absorption

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'ADME (absorption'

Author: Grafiati
Published: 5 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "ADME (absorption"

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Jyoti V. Mali, Jyoti V. Mali, Pratibha R. Adnaik Pratibha R. Adnaik, and Rahul S. Adnaik Rahul S. Adnaik. "Computational ADME Modeling of Selected Terpenoids Using Swiss ADME." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 1704–16. https://doi.org/10.35629/4494-100317041716.

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Terpenoids, a large and diverse class of naturally occurring organic compounds, have shown significant therapeutic potential, including antimicrobial, anticancer, and anti-inflammatory properties. However, the pharmacokinetic behavior of terpenoids, particularly their absorption, distribution, metabolism, and excretion (ADME) profiles, remains a critical factor in their drug development process. Computational ADME modeling has emerged as a powerful tool for earlystage screening of bioactive compounds, enabling the efficient prediction of pharmacokinetic properties and drug-likeness. This revie
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Katole, Ravindra Madhukar, Mukesh Kumar Sharma, and Chetan Kumar Joshi. "PREDICTION OF BIOLOGICAL ACTIVITIES OF A. SQUAMOSA BIOACTIVE COMPOUNDS BY-SILICO DESIGN." Journal of Advanced Scientific Research 12, no. 03 (2021): 119–23. http://dx.doi.org/10.55218/jasr.202112316.

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Annona squamosa L. belongs to the Annonaceae family and is one of the basic dietary plants with edible fruits and is called "custard apple. The aim of our study was to carry out to PASS Predication investigate potential Prediction of Activity Spectra for phytoconstituents from Alpinia calcarata namely Acetogenins, Isoquinoline, Quercetin 3 Oglucoside, phenanthrene and Anoreticuin towards many deasease. Server based in silico pass prediction of the compounds was performed. Selected phytochemicals were also analyzed for ADME/T properties using the ADMET protocol. Among a wide range of predicting
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Bououden, Walid, and Yacine Benguerba. "Designing, Cytotoxic Evaluation, Molecular Docking and in Silico Pharmacokinetic Prediction of New Hydrocortisone Derivatives as Anti-Asthmatics Drugs." Journal of Drug Delivery and Therapeutics 10, no. 4 (2020): 8–16. http://dx.doi.org/10.22270/jddt.v10i4.4128.

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A series of new 20 corticosteroids were subjected to molecular property prediction. The Molecular, Physicochemical, and Biological properties were determined using Molinspiration Cheminformatics software. These compounds were further subjected to Toxicity Predictions using the Osiris Software. The calculated drug-related properties of the designed molecules were similar to those found in most marketed drugs. Amongst the proposed molecules, fourteen promising candidates can be considered as promising structures for the synthesis of new and more effective anti-asthmatic drugs. Result indicates t
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Khare, Soumya, Tanushree Chatterjee, Shailendra Gupta, and Patel Ashish. "Bioavailability predictions, pharmacokinetics and drug-likeness of bioactive compounds from Andrographis paniculata using Swiss ADME." MGM Journal of Medical Sciences 10, no. 4 (2023): 651–59. http://dx.doi.org/10.4103/mgmj.mgmj_245_23.

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Abstract Background: Earlier research on Andrographis paniculata focused on documenting their bioactive compounds profiles and traditional use. Before making a drug-like substance prediction using information from in silico experimental models, the current work aimed to examine and analyze the ADMET properties. This study assessed the drug-likeness and ADMET characteristics of bioactive compounds from A. paniculata. Materials and Methods: The current study will be the first to use the free online tool Swiss ADME to report the ADME characteristics of A. paniculata. The ADME properties of 10 bio
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Ravi, Kumar K. 1. *. Archana Giri 1. Rama Rao Nadendla 2. "INSILICO ADME PROFILING OF CDK9 INHIBITORS." Journal of Scientific Research in Pharmacy 7, no. 3 (2018): 30–34. https://doi.org/10.5281/zenodo.1207094.

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<strong><em>ABSTRACT</em></strong> <strong><em>S</em></strong><em>everal drug targets have been identified in fighting against cancer. Inhibition of Cell cycle is one of the strategies used in anti-cancer research.&nbsp;&nbsp; CDKs [Cyclin Dependent Kinases] were found to be one of the promising drug targets. This work aims to find a potential molecule to inhibit CDKs that are involved in cell cycle progression. CDK 9 was chosen as potential drug target for cancer.&nbsp; Virtual screening was carried out against CDK 9 protein using Molecular Docking tools with molecules from ZINC database. Mol
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Asghar, Saira, and Rabia Iqtadar. "IN SILICO PHARMACOKINETIC PROFILING OF TRYPTAMINE DERIVATIVES BY SWISSADME AND ADMETSAR." Hamdard Journal of Pharmacy 2, no. 2 (2022): 34–40. http://dx.doi.org/10.61744/hjp.v2i2.54.

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Profiling of different pharmacokinetic parameters like the absorption, distribution, metabolism, and elimination known as ADME properties of drug molecules during initial phase of drug development might be beneficial in selection of molecules with less adverse ADME characteristics. ADME screening by in vivo testing is very time consuming, costly, and includes the animals. On the other hand, in silico ADME investigation is cheaper, better and offers correct results rapidly. In the current research study, the in-silico methods, namely SwissADME and admetSAR were used for brief and complete ADME
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Mishra, Shweta, and Rashmi Dahima. "IN VITRO ADME STUDIES OF TUG-891, A GPR-120 INHIBITOR USING SWISS ADME PREDICTOR." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 366–69. http://dx.doi.org/10.22270/jddt.v9i2-s.2710.

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Predicting the absorption, distribution, metabolism and elimination (ADME) profile of drug candidates before their synthesis, in the early stage of drug discovery, could help in selecting candidates with the less critical ADME profile. In vivo ADME assessment is found to be costly, time consuming and involve the lives of animals, so the in vitro ADME analysis is better, cheaper and provides accurate results quickly. TUG-891 is a GPR-120 inhibitor under clinical trials. The aim of the present study is to predict the in vitro ADME studies of TUG-891, to know the expected outcome of the clinical
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Li, Sanwang, Balázs Klencsár, Lieve Balcaen, Filip Cuyckens, Frederic Lynen, and Frank Vanhaecke. "A pre-column derivatization method allowing quantitative metabolite profiling of carboxyl and phenolic hydroxyl group containing pharmaceuticals in human plasma via liquid chromatography-inductively coupled plasma-tandem mass spectrometry (LC-ICP-MS/MS)." Journal of Analytical Atomic Spectrometry 33, no. 2 (2018): 274–82. http://dx.doi.org/10.1039/c7ja00385d.

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Landberg, Rikard, Claudine Manach, Frederiek-Maarten Kerckhof, et al. "Future prospects for dissecting inter-individual variability in the absorption, distribution and elimination of plant bioactives of relevance for cardiometabolic endpoints." European Journal of Nutrition 58, S2 (2019): 21–36. http://dx.doi.org/10.1007/s00394-019-02095-1.

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Abstract Purpose The health-promoting potential of food-derived plant bioactive compounds is evident but not always consistent across studies. Large inter-individual variability may originate from differences in digestion, absorption, distribution, metabolism and excretion (ADME). ADME can be modulated by age, sex, dietary habits, microbiome composition, genetic variation, drug exposure and many other factors. Within the recent COST Action POSITIVe, large-scale literature surveys were undertaken to identify the reasons and extent of inter-individual variability in ADME of selected plant bioact
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Shah, Rashmi. "Pharmacokinetics: Drug absorption, distribution, metabolism, and excretion (ADME)." Pharma Innovation 8, no. 1 (2019): 865–69. http://dx.doi.org/10.22271/tpi.2019.v8.i1n.25492.

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Dissertations / Theses on the topic "ADME (absorption"

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Lanevskij, Kiril. "Absorption and Tissue Distribution of Drug-Like Compounds: Quantitative Structure-Activity Relationship Analysis." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111003_114235-89858.

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The objective of this work was to develop mechanistic quantitative structure activity relationship models that would facilitate the assessment of drug properties related to their absorption and distribution in the body. The analysis involved several parameters reflecting the rate of passive diffusion across brain endothelium and intestinal epithelium, and thermodynamic constants related to drug distribution between plasma and tissues. Permeation through cellular transport barriers was modeled by nonlinear equations relating the passive diffusion rate to physicochemical properties of drugs: lip
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Lanevskij, Kiril. "Vaistinių junginių absorbcija ir pasiskirstymas audiniuose: kiekybinio struktūros ir aktyvumo ryšio analizė." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111003_114225-03220.

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Šiame darbe pristatomi mechanistiniai kiekybinio struktūros ir aktyvumo ryšio modeliai, skirti vaistinių junginių savybių, charakterizuojančių jų absorbciją ir pasiskirstymą organizme prognozavimui. Nagrinėjama keletas parametrų, apibūdinančių paprastos difuzijos per biologines membranas greitį, taip pat termodinaminės konstantos, aprašančios vaistų pasiskirstymą tarp kraujo plazmos ir audinių. Ląstelinių pernašos barjerų pralaidumas buvo modeliuojamas netiesinėmis lygtimis, siejančiomis paprastos difuzijos greitį su vaistų fizikocheminėmis savybėmis, tokiomis kaip lipofiliškumas, jonizacija,
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Shugarts, Sarah B. "The role of transporters in the absorption, distribution, metabolism and excretion (ADME) of orally administered drugs." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390104.

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Matos, Karina Silvia. "Estudos computacionais e experimentais da permeabilidade celular de candidatos a fármacos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-11052017-140338/.

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A absorção intestinal de fármacos (HIA, na sigla em inglês para human intestinal absorption) é um dos processos farmacocinéticos mais críticos para a ação de medicamentos administrados por via oral. Modelos in vitro baseados em células que mimetizam os enterócitos do intestino humano (células Caco-2), ou aqueles que utilizam membranas articifiais são muito utilizados no estudo da permeabilidade celular de moléculas bioativas. No processo de planejamento de fármacos, estas técnicas são frequentemente empregadas em paralelo com estratégias computacionais na avaliação de propriedades físico-quími
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Kim, Vera. "Frequência de polimorfismos nos genes responsáveis pela absorção, distribuição, metabolismo e excreção (ADME) de medicamentos na população brasileira." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-12092018-100648/.

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Introdução: A variação genética em genes que codificam a absorção, distribuição, metabolismo e excreção (ADME) de medicamentos frequentemente afeta a farmacocinética da droga e resulta na variabilidade da eficácia e segurança do medicamento. No entanto, a frequência da variação genética nos genes ADME diferem entre as populações. O objetivo deste estudo foi analisar as variações genéticas nos genes ADME nos pacientes brasileiros portadores do vírus da hepatite C e comparar com outros bancos de dados (1000 Genomes Project e Exome Aggregation Consortium). Métodos: Um total de 147 genes ADME fora
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Books on the topic "ADME (absorption"

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Lyubimov, Alexander V. Encyclopedia of Drug Metabolism and Interactions, Absorption, Distribution, Metabolism, and Excretion (ADME) of Drugs. Wiley & Sons, Incorporated, John, 2012.

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Lyubimov, Alexander V. Encyclopedia of Drug Metabolism and Interactions, Absorption, Distribution, Metabolism, and Excretion (ADME) of Drugs. Wiley & Sons, Incorporated, John, 2012.

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Lyubimov, Alexander V. Encyclopedia of Drug Metabolism and Interactions, Absorption, Distribution, Metabolism, and Excretion (ADME) of Drugs. Wiley & Sons, Incorporated, John, 2012.

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Book chapters on the topic "ADME (absorption"

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Talevi, Alan, and Carolina L. Bellera. "Drug Absorption." In The ADME Encyclopedia. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84860-6_50.

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Talevi, Alan, and Carolina L. Bellera. "Drug Absorption." In The ADME Encyclopedia. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-51519-5_50-1.

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Haas, Sandra Elisa, Fernando Carreño, and Teresa Dalla Costa. "Pharmaceutical Nanocarriers: Absorption." In The ADME Encyclopedia. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84860-6_111.

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Haas, Sandra Elisa, Fernando Carreño, and Teresa Dalla Costa. "Pharmaceutical Nanocarriers: Absorption." In The ADME Encyclopedia. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-51519-5_111-1.

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Talevi, Alan, and Carolina Leticia Bellera. "Drug Absorption." In ADME Processes in Pharmaceutical Sciences. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-99593-9_2.

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Talevi, Alan, and Carolina Leticia Bellera. "Drug Absorption." In ADME Processes in Pharmaceutical Sciences. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-50419-8_3.

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Talevi, Alan, and Carolina L. Bellera. "Free Diffusion in Drug Absorption." In The ADME Encyclopedia. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84860-6_44.

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Talevi, Alan, and Carolina L. Bellera. "Free Diffusion in Drug Absorption." In The ADME Encyclopedia. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-51519-5_44-1.

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Vázquez, Marta, R. Eiraldi, and C. Maldonado. "Rhythms in Pharmacokinetics: Absorption and Disposition." In The ADME Encyclopedia. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84860-6_161.

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Talevi, Alan, and Carolina L. Bellera. "Transcytosis in Drug Absorption and Distribution." In The ADME Encyclopedia. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84860-6_47.

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Conference papers on the topic "ADME (absorption"

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Kostić, Marina D., Jovana S. Marjanović, Sven Mangelinckx, and Vera M. Divac. "In silico Drug-Likeness, Pharmacokinetic and other ADME properties of 2- (aminomethyl)cyclopropane-1,1-dicarboxylic acid." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.455k.

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Herein we present the results of in silico determination of Drug-Likeness, Pharmacokinetic and other ADME properties of 2-(aminomethyl)cyclopropane-1,1-dicarboxylic acid as an example constrained γ-amino dicarboxylic acid. The results of in silico screening of drug-likeness, pharmacokinetic and other ADME (absorption, distribution, metabolism and elimination) properties of 2-(aminomethyl)cyclopropane-1,1-dicarboxylic acid have revealed that this compound is not able to cross the blood-brain barrier, but it shows good solubility and gastrointestinal absorption. The possible target screening has
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Krunić, Mihajlo J., Jelena Z. Penjišević, Slađana Kostić-Rajačić, Vladimir B. Šukalović, Deana B. Andrić, and Ivana I. Jevtić. "Pyrazole/tacrine derivatives as potential cholinesterase inhibitors." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.567k.

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Two new tacrine/pyrazole conjugates were designed, synthesized, and pharmacologically evaluated for their inhibitory activity toward acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). A scalable and cost-efficient synthetic route was developed, and key reaction steps for the synthesis of compounds 4a,b were nucleophilic substitution of α-aroylketene dithioacetals with tacrine intermediates, followed by cyclocondensation of respective N,S-acetals with hydrazine hydrate. The preliminary pharmacological evaluation revealed high inhibitory activities of 4a,b toward AChE (180 and 259 nM
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Bešlo, Drago, Dejan Agić, Vesna Rastija, Maja Karnaš, Domagoj Šubarić, and Bono Lučić. "Analysis of prediction of water solubility and lipophilicity of coumarins by free cheminformatics tools." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.657d.

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Pharmacokinetics of drugs involves the study of the drug’s path through the body, from its introduction to its final excretion from the body (Absorption, Distribution, Metabolism, and Excretion (ADME)). The basis of pharmacokinetic tests provides insight into the behavior of the tested substance after it is introduced into the body. They include consideration of the physicochemical properties of the medicinal substance, as well as its biopharmaceutical properties. Experimental measurements are often demanding and take a long time to conclude the continuation of further research, whether it is
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Naraghi, Mohammad H., and Adrien Harant. "Configuration of Building Fac¸ade Surface for Seasonal Selectiveness of Solar Irradiation: Absorption and Reflection." In ASME 2011 5th International Conference on Energy Sustainability. ASMEDC, 2011. http://dx.doi.org/10.1115/es2011-54127.

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A novel building fac¸ade surface configuration is proposed. This fac¸ade consists of grooved cavities that are configured in a manner that reflects summer (cooling season) insolation and absorbs winter (heating season) insolation. The effective absorptivities of the fac¸ade for various cavity reflectance characteristics, i.e., a wide range of diffuse and specular reflectance characteristics, are evaluated using a Monte Carlo model. It was determined the best cavity surface reflectivity is the one with fully diffuse surfaces and absorptivity of 0.7 or more. This reflectance characteristic of ca
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Stüber, W., D. Schiwek, U. Becker, and N. Heimburger. "NEW CHROMOGENIC SUBSTRATES FOR THE DETERMINATION OF COAGULATION AND FIBRINOLYSIS ENZYMES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644323.

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A new type of chromogenic substraces based on derivatives of phenoxazine is presented. Particularly interesting is the blue dye 7-amino-3-diethylamino-8-methylphenoxazine (ADMP) with a molar extinktion coefficient of about 80,000 at 624 nm. Peptides were linked to the aminogroup of the dye and red coloured substrates were obtained with a λmax value of about 540 nm. On account of the distinct difference of the λmax values and the negligable influence of the absorption peaks of the acylated and the free dye this chromophore is suitable for the synchesis of substrates. Besides the spectral proper
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Antonijević, Marko, Milica Kosović Perutović, Zorica Leka, and Zoran Marković. "Exploring the Pharmacokinetic Properties of (NH4)4[Fe(idadtc)2]: In Silico Biological screening and ADMET analysis." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.213a.

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Carbonic anhydrases (CA) have been identified in the early ‘50s as potential targets for the treatment of numerous diseases, including cancer, glaucoma, epilepsy, etc. Current inhibitors, i.e., treatment options, offer high efficacy coupled with a high probability of various side-effects. On the other hand, dithiocarbamates and their metal complexes are known for being good CA inhibitors. In this paper, a novel Fe (II) dithiocarbamato complex was investigated for its biological and pharmacological properties using a combination of different in silico methodologies. It was found that this water
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Maurerlehner, Paul, Dominik Mayrhofer, Mehdi Mehrgou, Manfred Kaltenbacher, and Stefan Schoder. "A Transient Numerical Analysis of a Dissipative Expansion Chamber Muffler." In 13th International Styrian Noise, Vibration & Harshness Congress: The European Automotive Noise Conference. SAE International, 2024. http://dx.doi.org/10.4271/2024-01-2935.

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&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Expansion chamber mufflers are commonly applied to reduce noise in heating, ventilation, and air-conditioning (HVAC) or exhaust systems. In dissipative mufflers, sound-absorptive materials, such as microperforated plates (MPP), are applied to achieve an enhanced and more broadband mitigation effect. Computational acoustics (CA) analyses of mufflers are usually carried out in the frequency domain, assuming time-harmonic excitation. However, certain applications require time-domain simulations. From a computational point o
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