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Dissertations / Theses on the topic 'ADME'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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1

Canault, Baptiste. "Développement d'une plateforme de prédiction in silico des propriétés ADME-Tox." Thesis, Orléans, 2018. http://www.theses.fr/2018ORLE2048/document.

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Dans le cadre de la recherche pharmaceutique, les propriétés relatives à l’Absorption, la Distribution, le Métabolisme, l’Elimination (ADME) et la Toxicité (Tox) sont cruciales pour le succès des phases cliniques lors de la conception de nouveaux médicaments. Durant ce processus, la chémoinformatique est régulièrement utilisée afin de prédire le profil ADME-Tox des molécules bioactives et d’améliorer leurs propriétés pharmacocinétiques. Ces modèles de prédiction, basés sur la quantification des relations structure-activité (QSAR), ne sont pas toujours efficaces à cause du faible nombre de donn
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2

Bercevič, Renata. "Antilipideminėmis savybėmis pasižyminčių vaistinių augalų veikliųjų medžiagų palyginamoji apžvalga ir raudonųjų dobilų (Trifolium pratense L.) žolės pritaikymo mažinti cholesterolio kiekį kraujyje pagrindimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110628_151406-22258.

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Darbo tikslas – apžvelgti Lietuvoje augančių antilipideminėmis savybėmis pasižyminčių augalų pritaikymo galimybes mažinti cholesterolio kiekį kraujyje bei pagrįsti raudonųjų dobilų terapinį potencialą. Tyrimo metodai. Bendrasis flavonoidų kiekis raudonųjų dobilų žolėje nustatytas UV spektrofotometrijos metodu. Raudonųjų dobilų veikliųjų medžiagų ADME savybių prognozė atlikta panaudojant ACD/ADME suite 5.0 programą. Statistinė analizė atlikta naudojant „Microsoft Office Excel 2003“ programą. Apskaičiuotas aritmetinis vidurkis ir standartinis nuokrypis. Tyrimo rezultatai. Daugiausia flavonoidų r
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3

Franchin, Taísa Busaranho. "Estudo de ADME de compostos derivados do ácido pirazinóico com atividade antimicobacteriana /." Araraquara, 2019. http://hdl.handle.net/11449/181126.

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Orientador: Rosangela Goncalves Peccinini<br>Resumo: A tuberculose é uma doença infectocontagiosa provocada pelo Mycobacterium tuberculosis que apesar de reconhecida a muitos anos, ainda tem ocorrência frequente na sociedade, assim como os casos de resistência aos medicamentos, que tem apresentado aumento significativo nos últimos anos. Na busca de novas estratégias para o tratamento, pesquisadores da Unifesp-Diadema desenvolveram novos compostos com potencial atividade antimicobacteriana, denominados pirazinoato de metila (I), pirazinoato de etila (II), pirazinoato de butila (III) e 2-(pirazi
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4

Lanevskij, Kiril. "Vaistinių junginių absorbcija ir pasiskirstymas audiniuose: kiekybinio struktūros ir aktyvumo ryšio analizė." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111003_114225-03220.

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Šiame darbe pristatomi mechanistiniai kiekybinio struktūros ir aktyvumo ryšio modeliai, skirti vaistinių junginių savybių, charakterizuojančių jų absorbciją ir pasiskirstymą organizme prognozavimui. Nagrinėjama keletas parametrų, apibūdinančių paprastos difuzijos per biologines membranas greitį, taip pat termodinaminės konstantos, aprašančios vaistų pasiskirstymą tarp kraujo plazmos ir audinių. Ląstelinių pernašos barjerų pralaidumas buvo modeliuojamas netiesinėmis lygtimis, siejančiomis paprastos difuzijos greitį su vaistų fizikocheminėmis savybėmis, tokiomis kaip lipofiliškumas, jonizacija,
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5

Lanevskij, Kiril. "Absorption and Tissue Distribution of Drug-Like Compounds: Quantitative Structure-Activity Relationship Analysis." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111003_114235-89858.

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The objective of this work was to develop mechanistic quantitative structure activity relationship models that would facilitate the assessment of drug properties related to their absorption and distribution in the body. The analysis involved several parameters reflecting the rate of passive diffusion across brain endothelium and intestinal epithelium, and thermodynamic constants related to drug distribution between plasma and tissues. Permeation through cellular transport barriers was modeled by nonlinear equations relating the passive diffusion rate to physicochemical properties of drugs: lip
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6

Piechota, Przemyslaw. "Development of in silico models for the prediction of toxicity incorporating ADME information." Thesis, Liverpool John Moores University, 2015. http://researchonline.ljmu.ac.uk/4554/.

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Drug discovery is a process that requires a significant investment in both time and resources. Although recent developments have reduced the number of drugs failing at the later stages of development due to poor pharmacokinetic and/or toxicokinetic profiles, late stage attrition of drug candidates remains a problem. Additionally, there is a need to reduce animal testing for toxicological risk assessment for ethical and financial reasons. In silico methods offer an alternative that can address these challenges. A variety of computational approaches have been developed in the last two decades, t
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7

Moda, Tiago Luiz. "Desenvolvimento de modelos in silico de propriedades de ADME para a triagem de novos candidatos a fármacos." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22032007-112055/.

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As ferramentas de modelagem molecular e de estudos das relações quantitativas entre a estrutura e atividade (QSAR) ou estrutura e propriedade (QSPR) estão integradas ao processo de planejamento de fármacos, sendo de extremo valor na busca por novas moléculas bioativas com propriedades farmacocinéticas e farmacodinâmicas otimizadas. O trabalho em Química Medicinal realizado nesta dissertação de mestrado teve como objetivo estudar as relações quantitativas entre a estrutura e as propriedades farmacocinéticas biodisponibilidade oral e ligação às proteínas plasmáticas. Para a realização deste trab
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8

Pauli, Ivaní. "Planejamento de inibidores da enzima cruzaína candidatos a fármacos para o tratamento da doença de Chagas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-26102016-151536/.

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A doença de Chagas é uma doença tropical negligenciada de alta prioridade nos programas de pesquisa e desenvolvimento da Organização Mundial da Saúde. Grave problema de saúde pública, é uma das maiores causas de desordens cardíacas em vários países da América Latina. A inexistência de um tratamento satisfatório faz urgente a busca por novas alternativas terapêuticas. Nesse contexto, o objetivo dessa tese de doutorado foi o desenvolvimento de inibidores da enzima cruzaína de Trypanosoma cruzi, alvo molecular validado para a doença de Chagas, utilizando de forma integrada várias estratégias expe
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9

Silva, Bruna Cristina Ulian. "Estudo de ADME de candidatos a fármacos para o tratamento da leishmaniose visceral e tripanossomíase americana /." Araraquara, 2019. http://hdl.handle.net/11449/181058.

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Orientador: Rosângela Gonçalves Peccinini<br>Resumo: Estudos precoces de ADME podem agilizar o processo de desenvolvimento de novos fármacos, selecionando os mais promissores para futuros estudos farmacocinéticos. Nesse sentido, e considerando a necessidade de novos tratamentos para a leishmaniose visceral e para a tripanossomíase americana, as moléculas LINS03006, LINS03011 e LINS03013 com ação sobre o Trypanosoma cruzi e a Leishmania infantum foram desenvolvidas por pesquisadores da UNIFESP/Diadema. O presente trabalho teve como objetivo realizar estudos físico-químicos e de ADME para a sele
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10

Hobbs, Michael. "The interplay of multiple ADME mechanisms : prediction of hepatic drug-drug interactions from in vitro." Thesis, University of Strathclyde, 2016. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=27533.

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Rosuvastatin has poor passive membrane permeability and its uptake into the liver is mediated predominately by the transporter, Organic Anion Transporting Polypeptide 1B1 (OATP1B1). Cyclosporin A (CsA) is a potent inhibitor of a range of transporters, including OATP1B1 and clinical drug-drug interactions (DDI) have been reported with rosuvastatin. The aim of this study was to determine the uptake kinetics of rosuvastatin in human hepatocytes using a mechanistic model and to determine the inhibitory effect of CsA upon those kinetics. These data may then allow the extrapolation of in vitro to in
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11

Shugarts, Sarah B. "The role of transporters in the absorption, distribution, metabolism and excretion (ADME) of orally administered drugs." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390104.

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12

Espíndola, Leandro. "Síntese, atividade biológica e propriedades ADME de novos derivados quinolínicos contendo o núcleo pirazolina e tiazol." reponame:Repositório Institucional da UFSC, 2017. https://repositorio.ufsc.br/xmlui/handle/123456789/182894.

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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, 2017.<br>Made available in DSpace on 2018-01-30T03:18:35Z (GMT). No. of bitstreams: 1 349406.pdf: 6078070 bytes, checksum: 07258311b7215f933a4e13f8b55ec123 (MD5) Previous issue date: 2017<br>No presente trabalho realizou-se a síntese e investigação de atividades biológicas e propriedades ADME (absorção, distribuição, metabolismo e excreção) de novos derivados quinolínicos contendo o núcleo pirazolina e tiazol. A obtenção dos compostos se deu seguindo a ro
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13

Matos, Karina Silvia. "Estudos computacionais e experimentais da permeabilidade celular de candidatos a fármacos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-11052017-140338/.

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A absorção intestinal de fármacos (HIA, na sigla em inglês para human intestinal absorption) é um dos processos farmacocinéticos mais críticos para a ação de medicamentos administrados por via oral. Modelos in vitro baseados em células que mimetizam os enterócitos do intestino humano (células Caco-2), ou aqueles que utilizam membranas articifiais são muito utilizados no estudo da permeabilidade celular de moléculas bioativas. No processo de planejamento de fármacos, estas técnicas são frequentemente empregadas em paralelo com estratégias computacionais na avaliação de propriedades físico-quími
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14

Wegner, Jörg Kurt. "Data mining und graph mining auf molekularen Graphen - Cheminformatik und molekulare Kodierungen für ADME/Tox-QSAR-Analysen." Berlin Logos, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?id=2865580&prov=M&dok_var=1&dok_ext=htm.

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15

Reddy, Badinehal Asrith. "COMMERCIALIZATION OF A QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP TOOL - SARCHITECT." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1295637833.

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16

Fournier, Agnès. "Transfert de Polluants Organiques Persistants (POP) vers l’œuf de poule : influence des caracteristiques des polluants et du statut physiologique de l’animal." Thesis, Vandoeuvre-les-Nancy, INPL, 2011. http://www.theses.fr/2011INPL031N/document.

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Les poules pondeuses sont susceptibles d’être exposées à des polluants organiques persistants (POP) potentiellement présents dans leur environnement. Dans un contexte de sécurisation des systèmes d’élevage avicole vis-à-vis des POP, nous avons étudié les facteurs influençant le transfert des POP ingérés vers l’œuf. Ces facteurs sont liés à la nature de la matrice ingérée (sol ou aliment), aux caractéristiques de l’animal (taux de ponte, état d’engraissement) et aux caractéristiques de la molécule (lipophilicité, susceptibilité à la métabolisation). Pour cette étude, différentes approches scien
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17

Kim, Vera. "Frequência de polimorfismos nos genes responsáveis pela absorção, distribuição, metabolismo e excreção (ADME) de medicamentos na população brasileira." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-12092018-100648/.

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Introdução: A variação genética em genes que codificam a absorção, distribuição, metabolismo e excreção (ADME) de medicamentos frequentemente afeta a farmacocinética da droga e resulta na variabilidade da eficácia e segurança do medicamento. No entanto, a frequência da variação genética nos genes ADME diferem entre as populações. O objetivo deste estudo foi analisar as variações genéticas nos genes ADME nos pacientes brasileiros portadores do vírus da hepatite C e comparar com outros bancos de dados (1000 Genomes Project e Exome Aggregation Consortium). Métodos: Um total de 147 genes ADME fora
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18

Baron, G. "MASS SPECTROMETRIC STRATEGIES FOR THE STUDY OF PLANT EXTRACTS BIOAVAILABILITY, BIOACTIVITY AND MECHANISMS OF ACTION." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/540325.

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1. Introduction and aim of the work Drug discovery in phytomedicine has in the past been mainly focused on the isolation and characterization of new bioactive compounds from natural products. Several NCE (new chemical entities) have been isolated from plants and they are now the active principles of many drugs able to treat and prevent different kinds of diseases. This drug discovery approach is aimed at the determination of the single "active principle" in plants, based on the assumption that a plant has one or more ingredients which determine its therapeutic effects. Beside NCE derived fr
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19

Tremmel, Roman [Verfasser], and Ulrich M. [Akademischer Betreuer] Zanger. "Bioinformatische Analyse und funktionelle Charakterisierung von strukturellen Genvarianten in ADME-Genen in humaner Leber / Roman Tremmel. Betreuer: Ulrich M. Zanger." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2016. http://d-nb.info/1105554260/34.

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20

Forbes, Whitney. "Physiologically-Based Pharmacokinetic Model for Ertapenem." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etd/2342.

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Ertapenem is a carbapenem used to treat a wide range of bacterial infections. What sets ertapenem apart from other carbapenems is its longer half-life which implies it need only be administered once daily. We developed a physiologically-based pharmacokinetic model for the distribution of ertapenem within the body. In the model, parameters such as human body weight and height, age, organ volumes, blood flow rates, and partition coefficients of particular tissues are used to examine the absorption, distribution, metabolism, and excretion of ertapenem. The total and free blood concentrations foun
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21

Rango, Enrico. "PRECLINICAL CHARACTERIZATION OF SFK INHIBITORS, PYRAZOLO[3,4-d]PYRIMIDINE SCAFFOLD-BASED DERIVATIVES, FOR CANCER TREATMENT." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1140389.

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The first part of this thesis essentially focuses on the preclinical characterization of Si306, a pyrazolo[3,4-d]pyrimidine derivative, identified as a very promising anticancer agent. This compound has shown a favorable in vitro and in vivo activity profile against neuroblastoma (NB) and glioblastoma (GBM) models by acting as a competitive inhibitor of c-Src tyrosine kinase. Nevertheless, the good antitumor activity of Si306 is associated with sub-optimal aqueous solubility, which might hinder its further development. In this context, drug delivery systems were developed to overcome the poor
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22

Martiny, Virginie. "Vers la prédiction des propriétés ADME-Tox des molécules à visée thérapeutique par une approche basée sur la structure des enzymes du métabolisme." Paris 7, 2013. http://www.theses.fr/2013PA077175.

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Lors de la conception de médicaments, prédire les propriétés d'Absorption, Distribution, Métabolisme, Excrétion, Toxicité (ADME-Tox) des molécules à visée thérapeutique permet d'éliminer celles qui ne seraient pas de bons candidats-médicaments. Les enzymes du métabolisme sont capables de modifier les propriétés ADME-Tox des molécules avec lesquelles elles interagissent ou sont impliquées dans des interactions médicamenteuses. Ainsi, les cytochromes P450 (CYPs) et les sulfotransférases (SULTs) sont des enzymes du métabolisme catalysant respectivement des réactions d'oxydation et de sulfoconjuga
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23

Perrine, Zeller. "Cyanotoxines et barrière intestinale humaine: Étude comparée de l'absorption et de la toxicité de deux variants de microcystine sur le modèle cellulaire Caco-2." Phd thesis, Agrocampus - Ecole nationale supérieure d'agronomie de rennes, 2011. http://tel.archives-ouvertes.fr/tel-00634649.

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Les microcystines (MCs), hépatotoxines produites par des cyanobactéries d'eau douce, sont incriminées dans des intoxications humaines et animales. L'ingestion est leur principale voie d'exposition chez l'homme. Parmi les quelques 90 variants décrits, la MC-LR constitue le variant le plus toxique et le mieux connu sur lequel est fondé l'évaluation du risque associé aux MCs. Afin de mieux caractériser le danger pour l'homme par ingestion, nous avons choisi d'étudier et de comparer l'absorption et la toxicité de deux variants, la MC-LR et la MC-RR, sur un modèle cellulaire intestinal humain, les
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24

Bolteau, Raphaël. "Conception, synthèse et évaluation pharmacologique d’antagonistes des récepteurs A2A et de ligands duaux ciblant les récepteurs A2A et mGlu5." Thesis, Lille 2, 2020. http://www.theses.fr/2020LIL2S006.

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Ces cinquante dernières années ont été marquées par la percée des maladies neurodégénératives comme la maladie d’Alzheimer. À ce jour, il existe uniquement des traitements symptomatiques. De plus, face à cette maladie multifactorielle, il apparaît donc nécessaire d’identifier et d’étudier de nouvelles cibles thérapeutiques. Parmi elles, le récepteur à l’adénosine A2A (A2AR) a fait l’objet de nombreuses études ces dernières années. En effet, ses antagonistes tels que la caféine ont montré de nombreux effets bénéfiques en permettant d’améliorer les performances cognitives par une diminution des
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25

Lindgren, Maria T. "Exploring Inhibitors of HIV-1 Protease : Interaction Studies with Applications for Drug Discovery." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4655.

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26

GILARDONI, ETTORE. "AN INTEGRATED PROTEOMIC AND ANALYTICAL APPROACH FOR ELUCIDATING THE MECHANISM OF ACTION OF HISTIDINE DIPEPTIDES AND SYNTHETIC DERIVATES." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/797770.

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β-alanil-L-istidina (carnosina) è un peptide endogeno che possiede innumerevoli proprietà (chelante dei metalli, antiossidante, sequestrante delle specie reattive carboniliche). Diversi studi clinici hanno dimostrato un’attività farmacologica della carnosina in malattie su base ossidative, tuttavia il meccanismo dell’attività in vivo non è ancora noto. Questo progetto ha come scopo quello di comprendere il meccanismo in vivo della carnosina. Per far ciò, sono stati sviluppati nuovi metodi analitici di cromatografia liquida accoppiata a spettrometria di massa per la quantificazione in ca
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27

Aitken, Steven Geoffrey. "Design, synthesis and testing of β-strand mimics as protease inhibitors". Thesis, University of Canterbury. Chemistry, 2006. http://hdl.handle.net/10092/1984.

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Chapter 1 gives background information on proteases and discusses the concept of protease inhibition as a therapeutic strategy for humans. It introduces the key concept that conformation defines biological activity. It also outlines how proteases almost universally bind their substrate/inhibitors in an extended β-strand conformation. The use of calpain as a prototype protease for the testing of β-strand mimics synthesised later in the thesis is also discussed. Chapter 2 describes how molecular modeling was used to rationalise the structure based activity relationships (SAR) of known calpain in
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28

Habka, Dany. "Modélisation toxico-pharmacocinétique à partir de méthodes bioinformatiques et de tests in vitro." Compiègne, 2011. http://www.theses.fr/2011COMP1941.

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L'objectif de la thèse est de développer et d'évaluer une approche alternative pour prédire les profils cinétiques de molécules chez l'Homme. Dans cette approche, la disposition de substance dans l'organisme est décrite par un modèle PBPK. Ce dernier est paramétré en utilisant des outils statistiques et diverses sources d'informations. La paramétrisation du modèle PBPK dans le cadre d'une approche intégrée in silico/in vitro a été évaluée. Nos résultats ont montré que la pertinence des prédictions du profil cinétique dépend de la qualité des données et de l'état de notre connaissance sur la mo
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Uusitalo, J. (Jouko). "The role of drug metabolism in drug discovery and development:case ospemifene." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526210223.

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Abstract Drug metabolism is one of the most important events a drug faces after administration. Traditionally, drug metabolism has only been considered as a major clearance and elimination step in the pharmacokinetics of a drug. However, drug metabolism is also one of the important factors behind safety and toxicity issues in drug discovery and development. Some of the mechanisms behind metabolism-related toxicity we do understand well while others, especially the role of reactive metabolites, need further research. The thesis reviews the role of drug metabolism in the drug discovery and devel
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Adem, Abdu [Verfasser]. "University-Industry Partnership in Ethiopia / Abdu Adem." München : GRIN Verlag, 2021. http://d-nb.info/1233009559/34.

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31

Teixeira, Rosa Amélia Pratas. "O futuro da ADSE : autossustentabilidade do subsistema." Master's thesis, FEUC, 2014. http://hdl.handle.net/10316/27488.

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32

Fournier, Agnès. "Transfert de Polluants Organiques Persistants (POP) vers l’œuf de poule : influence des caracteristiques des polluants et du statut physiologique de l’animal." Electronic Thesis or Diss., Vandoeuvre-les-Nancy, INPL, 2011. http://www.theses.fr/2011INPL031N.

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Les poules pondeuses sont susceptibles d’être exposées à des polluants organiques persistants (POP) potentiellement présents dans leur environnement. Dans un contexte de sécurisation des systèmes d’élevage avicole vis-à-vis des POP, nous avons étudié les facteurs influençant le transfert des POP ingérés vers l’œuf. Ces facteurs sont liés à la nature de la matrice ingérée (sol ou aliment), aux caractéristiques de l’animal (taux de ponte, état d’engraissement) et aux caractéristiques de la molécule (lipophilicité, susceptibilité à la métabolisation). Pour cette étude, différentes approches scien
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33

Iannone, Lucio. "ADMA metabolism and chronic hypoxia-induced pulmonary hypertenstion." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24911.

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Rationale: Elevated asymmetric dimethylarginine (ADMA) levels contribute to the pathogenesis of hypoxia-induced pulmonary hypertension. Chronic hypoxia decreases the activity of the enzymes metabolising ADMA, dimethylarginine dimethylaminohydrolases (DDAH1 and DDAH2) but the mechanisms responsible are not understood. Objective: To elucidate the physiological significance and the mechanism of hypoxia-induced downregulation of ADMA metabolism. Methods and Results: Exposure of human pulmonary artery endothelial cells (HPAECs) to hypoxia inhibited both DDAH1 and DDAH2 gene and protein expression,
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34

Queen, André Sampaio. "Simulador de reatores anaeróbios com base no ADM1." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/3/3139/tde-04092006-170243/.

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Primeiramente, esse trabalho pretende esclarecer a importância de pesquisas em modelagem, simulação e controle nos processos de tratamento de efluentes e apontar o atraso do Brasil nesta área de pesquisa comparado ao avanço das iniciativas internacionais. O trabalho apresenta o problema específico da modelagem dos processos anaeróbios e propõe uma nova ferramenta de simulação de regime permanente para esses sistemas, desde digestores de lodo a reatores UASB. O simulador se baseia no ADM1 (Anaerobic Digestion Model No 1), modelo proposto pela IWA em 2002, e está implementado em C++. A intenção
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35

Tejkl, Jakub. "Trvanlivost destiček ADMX při frézování materiálů skupiny S." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231383.

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This diploma thesis studies the machining of group S materials. In the theoretical part of this thesis these materials were divided into groups and subsequently analyzed. These materials were also analyzed in terms of their impaired machinability. In the practical part of this thesis experimental tests were conducted to determine tool life, tool wear and in the case of testing titanium alloy surface roughness too.
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36

Imhof-Rudolph, Heike. "Wehrpflicht ade - tut Scheiden weh?" Universität Potsdam, 2010. http://opus.kobv.de/ubp/volltexte/2010/4897/.

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Wieviel Bundeswehr braucht Deutschland? Und wozu? Das primäre Ziel der Bundeswehr, die Landesverteidigung, ist ein genauso antiquierter Begriff wie ihre Struktur. Welche Transformation der Streitkräfte ist geboten?
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37

Perroni, Fabio. "Orbifold Cohomology of ADE-singularities." Doctoral thesis, SISSA, 2005. http://hdl.handle.net/20.500.11767/4241.

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In Chapter 1 we collect some basic definitions on orbifolds, morphisms of orbifolds and orbifold vector bundles. In Chapter 3 we first review the definition of orbifold cohomology ring for a complex orbifold, then we state the cohomological crepant resolution conjecture as given by Ruan in [52]. In Chapter 4 we define orbifolds with transversal ADE-singularities, see Definition 4.2.5. Then we give a description of the twisted sectors in general. Finally we specialize to orbifolds with transversal A_n-singularities and, under the technical assumption of trivial monodromy, we compute the orbifo
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38

Tomlinson, James. "The role of DDAH and ADMA in kidney disease." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24541.

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Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis and elevated plasma levels associate with poor cardiovascular and renal outcomes. The dimethylarginine dimethylaminohydrolase enzymes (DDAHs; 1 and 2) metabolise ADMA. A DDAH1 gene variant associates with higher kidney tissue mRNA expression, lower plasma ADMA but counter-intuitively, a steeper rate of eGFR decline. This indicates that renal DDAH1 activity may be deleterious and circulating ADMA does not necessarily reflect the NO-ADMA balance (or severity of disease) within kidney tissue. This study t
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Annergren, Mariette. "Application-Oriented Input Design and Optimization Methods Involving ADMM." Doctoral thesis, KTH, Reglerteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-187890.

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This thesis is divided into two main parts. The first part considers application-oriented input design, specifically for model predictive control (MPC). The second part considers alternating direction method of multipliers (ADMM) for ℓ1 regularized optimization problems and primal-dual interior-point methods. The theory of system identification provides methods for estimating models of dynamical systems from experimental data. This thesis is focused on identifying models used for control, with special attention to MPC. The objective is to minimize the cost of the identification experiment whil
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40

Foster, Louise. "Microalgae culture to treat anaerobic digestion abattoir effluent (ADAE)." Thesis, Foster, Louise (2019) Microalgae culture to treat anaerobic digestion abattoir effluent (ADAE). Masters by Coursework thesis, Murdoch University, 2019. https://researchrepository.murdoch.edu.au/id/eprint/51443/.

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Current abattoir wastewater treatment options involving aerobic and anaerobic digestion systems are relatively inefficient in reducing the inorganic nutrient load (i.e. ammonium and phosphate) of the effluent. With anaerobic lagoons favoured in Australia resulting in large land footprint, loss of environmental and economic value in the form of water and nutrient recovery. The cultivation of microalgae on undiluted anaerobic digestion abattoir effluent (ADAE) offers many potential benefits such as the bioremediation of waste nutrients typically found in the effluent and simultaneous production
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Gibson, Leia. "Microalgal cultivation to treat anaerobically digested domestic effluent (ADDE)." Thesis, Gibson, Leia (2020) Microalgal cultivation to treat anaerobically digested domestic effluent (ADDE). Masters by Research thesis, Murdoch University, 2020. https://researchrepository.murdoch.edu.au/id/eprint/59417/.

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In this study, the cultivation of microalgae in anaerobically digested domestic effluent (ADDE) was evaluated. Based on the knowledge from other literature, this is the first study of its kind. The ADDE was sourced from a local wastewater treatment plant (WWTP) which had a total ammonia content of approximately 1000 - 1500 mg L-1 NH3+-N. The overarching aim of this study was to identify the optimal nutrient concentration to maximise the growth of the mixed microalgal consortium (Chlorella and Scenedesmus species) in the ADDE supernatant. Apart from this, the growth comparison of microalgae cul
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42

Abboud, Azary. "Optimisation distribuée dans les grands systèmes interconnectés avec ADMM." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLC004/document.

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Cette thèse porte sur la construction des algorithmes distribués pour l’optimisation de la production et du partage de ressources au sein d’un réseau de large dimension. Notamment, on se concentre sur les réseaux électriques et les réseaux cellulaires 5G. On considère dans le cas des réseaux électriques le problème OPF (Optimal Power Flow) dans lequel on vise à faire la gestion et l’optimisation de la production de l’énergie électrique d’une manière distribuée. On se concentre sur une version linéarisée du problème, la DC-OPF (Direct-Current Optimal Power Flow). Comme le problème d’optimisatio
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43

Hou, Yuhang [Verfasser], and Katrin [Akademischer Betreuer] Wendland. "Elliptic genera of ADE type singularities." Freiburg : Universität, 2021. http://d-nb.info/1228270201/34.

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44

Bagli, Maria Chiara. "ll metodo ADMM per la regolarizzazione con Variazione Totale Generalizzata." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20966/.

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La tesi tratta del Metodo dei Moltiplicatori a Direzione Alternata (ADMM) per il problema di ricostruzione di immagini con il funzionale di Variazione Totale Generalizzata (TGV). Tale funzionale è convesso e dipende da due parametri positivi reali il cui valore influenza la qualità dell'immagine ricostruita. Parte del lavoro di tesi è stato dedicato al settaggio dei parametri, in particolare alla scelta del parametro di regolarizzazione, dei due parametri da cui dipende il funzionale TGV e dai parametri specifici del metodo ADMM. Si è compiuta un'analisi comparativa tra il metodo ADMM e il met
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Grimes, Dennis R. "An ADPE protest primer : lessons learned from GSBCA protest decisions." Thesis, Monterey, California. Naval Postgraduate School, 1991. http://hdl.handle.net/10945/26346.

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The General Services Administration's Board of Contract Appeals (GSBCA) is a significant venue for Federal Automated Data Processing Equipment (ADPE) protests. Since the GSBCA was granted jurisdiction over Brooks Act ADPE procurements in 1985, over 1,200 decisions have been rendered. Developing lessons learned from these protest decisions will benefit Federal ADPE managers by increasing awareness of the protest process. The highly complex Federal ADPE acquisition process is governed by numerous statutes and regulations. This study also discusses the pertinent statutory background of the protes
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46

Piolanti, Simone. "Il formalismo ADM per la metrica FLRW." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020.

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Il tema centrale di questo elaborato è la cosmologia, affrontata in ambito di relatività generale applicando il formalismo ADM al modello FLRW. Il problema consiste nella risoluzione delle equazioni di Einstein in presenza di materia. Sfruttando quindi il formalismo ADM sono innanzitutto definite le formulazioni lagrangiana ed hamiltoniana di una teoria in ambito di relatività generale. In particolare sono descritte tali formulazioni per le equazioni di Einstein. Segue come applicazione l'esempio della particella libera relativistica interpretata come teoria di campo in una dimensione. È infin
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47

Mazzucato, Luca. "ADE superpotentials, Seiberg Duality and Matrix Models." Doctoral thesis, SISSA, 2005. http://hdl.handle.net/20.500.11767/4166.

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In this thesis we study some issues of the nonperturbative dynamics of N=1 supersymmetric gauge theories. we consider SQCD with two chiral superfields in the adjoint representation and superpotential deformations, whose flows fall into Arnold's ADE classification of simple singularities. We study in detail the confining phase deformation of the An SQCD and its Seiberg dual in the classical and quantum chiral ring and find the duality map by means of the DV method. Then we analyze the deformation of the Dn+2 SQCD and describe its three classical branches and its cubic curve. In all the cases we
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48

Duroux, Romain. "Conception, synthèse et évaluation d'antagonistes des récepteurs A2A." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL2S015/document.

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La maladie d’Alzheimer (MA) est la maladie neurodégénérative touchant le plus de personnes dans le monde. Jusqu’à présent, aucun traitement curatif n’existe pour soigner cette maladie, d’où la nécessité d’identifier et d’étudier de nouvelles cibles thérapeutiques.La découverte des effets bénéfiques de la caféine, antagoniste du récepteur à adénosine A2A (A2AR), conjuguée à une surexpression de ce dernier chez les patients atteints de la MA, font de ce récepteur une cible d’intérêt. En effet, des antagonistes des A2ARs ont montré leur capacité à améliorer les performances cognitives de par une
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49

Mariño, Patrícia Albano. "Estudo de Chalconas como Antibacterianos Potenciais: Síntese, Avaliação da Ação Antibacteriana e das Propriedades Físico-químicas." Universidade Federal do Pampa, 2014. http://dspace.unipampa.edu.br:8080/xmlui/handle/riu/238.

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Submitted by Sandro Camargo (sandro.camargo@unipampa.edu.br) on 2015-05-08T03:06:29Z No. of bitstreams: 1 127110046.pdf: 2895137 bytes, checksum: edf417bbba917e277ef644cfa24efbf9 (MD5)<br>Made available in DSpace on 2015-05-08T03:06:29Z (GMT). No. of bitstreams: 1 127110046.pdf: 2895137 bytes, checksum: edf417bbba917e277ef644cfa24efbf9 (MD5) Previous issue date: 2014-07-21<br>As chalconas são compostos de origem vegetal e apresentam estrutura química simples que é amplamente utilizada como molécula protótipo para a obtenção de novos compostos bioativos através de modificações estrutura
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jaafar, hussein amez. "AGING AND DECISION MAKING AS MEASURED BY THE SWEDISH VERSION OF THE ADMC BATTERY." Thesis, Umeå universitet, Institutionen för psykologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-68356.

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The aim of this study was to examine age-related differences in decision-making competence. The study is a part of the ongoing Betula project (Nilsson et al., 1997; 2004), and the data included test results from (N, 364) corresponding to the questionnaires with complete responses (&gt;80%) to the items addressed. The Swedish version of the Adult Decision-Making Competence (A-DMC) battery was used. An exploratory factor analysis of the A-DMC data yielded a two-component solution: The A-DMC tasks were divided into Factor 1 (Applying Decision Rules, Resistance to Framing and Consistency in Risk P
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