Relevant bibliographies by topics / ADN quadruplexe

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'ADN quadruplexe'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "ADN quadruplexe"

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Koralewska, Natalia, Agnieszka Szczepanska, Kinga Ciechanowska, et al. "RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity." Cellular and Molecular Life Sciences 78, no. 7 (2021): 3709–24. http://dx.doi.org/10.1007/s00018-021-03795-w.

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AbstractGuanine (G)-rich single-stranded nucleic acids can adopt G-quadruplex structures. Accumulating evidence indicates that G-quadruplexes serve important regulatory roles in fundamental biological processes such as DNA replication, transcription, and translation, while aberrant G-quadruplex formation is linked to genome instability and cancer. Understanding the biological functions played by G-quadruplexes requires detailed knowledge of their protein interactome. Here, we report that both RNA and DNA G-quadruplexes are bound by human Dicer in vitro. Using in vitro binding assays, mutation
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Sanchez-Martin, Victoria, Carmen Lopez-Pujante, Miguel Soriano-Rodriguez, and Jose A. Garcia-Salcedo. "An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer." International Journal of Molecular Sciences 21, no. 23 (2020): 8900. http://dx.doi.org/10.3390/ijms21238900.

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Non-canonical, four-stranded nucleic acids secondary structures are present within regulatory regions in the human genome and transcriptome. To date, these quadruplex structures include both DNA and RNA G-quadruplexes, formed in guanine-rich sequences, and i-Motifs, found in cytosine-rich sequences, as their counterparts. Quadruplexes have been extensively associated with cancer, playing an important role in telomere maintenance and control of genetic expression of several oncogenes and tumor suppressors. Therefore, quadruplex structures are considered attractive molecular targets for cancer t
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Savva, Loukiani, and Savvas N. Georgiades. "Recent Developments in Small-Molecule Ligands of Medicinal Relevance for Harnessing the Anticancer Potential of G-Quadruplexes." Molecules 26, no. 4 (2021): 841. http://dx.doi.org/10.3390/molecules26040841.

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G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in recent years as novel targets, with untapped potential for anticancer research. Their potential stems from the fact that G-quadruplexes occur in functionally-important regions of the human genome, such as the telomere tandem sequences, several proto-oncogene promoters, other regulatory regions and sequences of DNA (e.g., rDNA), as well as in mRNAs encoding for proteins with roles in tumorigenesis. Modulation of G-quadruplexes, via interaction with high-affinity ligands, leads to their stabilization, with num
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Kotkowiak, Weronika, and Anna Pasternak. "Beyond G-Quadruplexes—The Effect of Junction with Additional Structural Motifs on Aptamers Properties." International Journal of Molecular Sciences 22, no. 18 (2021): 9948. http://dx.doi.org/10.3390/ijms22189948.

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G-quadruplexes constitute an important type of nucleic acid structure, which can be found in living cells and applied by cell machinery as pivotal regulatory elements. Importantly, robust development of SELEX technology and modern, nucleic acid-based therapeutic strategies targeted towards various molecules have also revealed a large group of potent aptamers whose structures are grounded in G-quadruplexes. In this review, we analyze further extension of tetraplexes by additional structural elements and investigate whether G-quadruplex junctions with duplex, hairpin, triplex, or second G-quadru
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Nowak-Karnowska, Joanna, Agata Głuszyńska, Joanna Kosman, Grażyna Neunert, and Anna Dembska. "Interaction of 9-Methoxyluminarine with Different G-Quadruplex Topologies: Fluorescence and Circular Dichroism Studies." International Journal of Molecular Sciences 22, no. 19 (2021): 10399. http://dx.doi.org/10.3390/ijms221910399.

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The interactions of G–quadruplexes of different topologies with highly fluorescent 9-methoxyluminarine ligand 9-MeLM were investigated by fluorescence and circular dichroism spectroscopy. The results showed that 9-methoxyluminarine was able to interact and did not destabilize any investigated molecular targets. The studied compound was selectively quenched by parallel c-MYC G-quadruplex DNA, whereas hybrid and antiparallel G4 topology caused only a negligible decrease in the fluorescence of the ligand. A high decrease of fluorescence of the ligand after binding with c-MYC G-quadruplex suggests
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Lauria, Antonino, Gabriele La Monica, Alessio Terenzi, et al. "Antiproliferative Properties and G-Quadruplex-Binding of Symmetrical Naphtho[1,2-b:8,7-b’]dithiophene Derivatives." Molecules 26, no. 14 (2021): 4309. http://dx.doi.org/10.3390/molecules26144309.

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Background: G-quadruplex (G4) forming sequences are recurrent in telomeres and promoter regions of several protooncogenes. In normal cells, the transient arrangements of DNA in G-tetrads may regulate replication, transcription, and translation processes. Tumors are characterized by uncontrolled cell growth and tissue invasiveness and some of them are possibly mediated by gene expression involving G-quadruplexes. The stabilization of G-quadruplex sequences with small molecules is considered a promising strategy in anticancer targeted therapy. Methods: Molecular virtual screening allowed us iden
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Bizyaeva, Anastasia A., Dmitry A. Bunin, Valeria L. Moiseenko, et al. "The Functional Role of Loops and Flanking Sequences of G-Quadruplex Aptamer to the Hemagglutinin of Influenza a Virus." International Journal of Molecular Sciences 22, no. 5 (2021): 2409. http://dx.doi.org/10.3390/ijms22052409.

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Nucleic acid aptamers are generally accepted as promising elements for the specific and high-affinity binding of various biomolecules. It has been shown for a number of aptamers that the complexes with several related proteins may possess a similar affinity. An outstanding example is the G-quadruplex DNA aptamer RHA0385, which binds to the hemagglutinins of various influenza A virus strains. These hemagglutinins have homologous tertiary structures but moderate-to-low amino acid sequence identities. Here, the experiment was inverted, targeting the same protein using a set of related, parallel G
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Volná, Adriana, Martin Bartas, Václav Karlický, et al. "G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story." International Journal of Molecular Sciences 22, no. 14 (2021): 7381. http://dx.doi.org/10.3390/ijms22147381.

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G-quadruplexes have long been perceived as rare and physiologically unimportant nucleic acid structures. However, several studies have revealed their importance in molecular processes, suggesting their possible role in replication and gene expression regulation. Pathways involving G-quadruplexes are intensively studied, especially in the context of human diseases, while their involvement in gene expression regulation in plants remains largely unexplored. Here, we conducted a bioinformatic study and performed a complex circular dichroism measurement to identify a stable G-quadruplex in the gene
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Novotný, Jan, Yevgen P. Yurenko, Petr Kulhánek, and Radek Marek. "Tailoring the properties of quadruplex nucleobases for biological and nanomaterial applications." Phys. Chem. Chem. Phys. 16, no. 29 (2014): 15241–48. http://dx.doi.org/10.1039/c4cp00541d.

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Raguseo, Federica, Souroprobho Chowdhury, Aisling Minard, and Marco Di Antonio. "Chemical-biology approaches to probe DNA and RNA G-quadruplex structures in the genome." Chemical Communications 56, no. 9 (2020): 1317–24. http://dx.doi.org/10.1039/c9cc09107f.

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G-quadruplexes are nucleic-acids secondary structures that can be formed under physiological conditions. In this review, we critically present the most relevant chemical-biology methods to probe the biological functions of G-quadruplex structures.
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Dissertations / Theses on the topic "ADN quadruplexe"

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Allain, Clémence. "Sondes fluorescentes pour l'ADN : marquage covalent et non-covalent." Paris 6, 2006. https://tel.archives-ouvertes.fr/tel-00202422.

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Le marquage fluorescent de biomolécules est devenu un outil incontournable en biologie. Dans ce contexte, nous avons conçu de nouvelles sondes fluorescentes pour l’ADN. Le marquage non-covalent d’ADN quadruplexe (ADN-G4) par reconnaissance structurale a été étudié. Les propriétés mitigées des composés obtenus en conjuguant un ligand d’ADN-G4 à des sondes fluorescentes nous ont conduit à étudier le Thiazole Orange (TO), dont la fluorescence est exaltée par l’ADN. Le TO a une forte affinité pour l’ADN-G4, qui exalte fortement sa fluorescence. L’affinité d’un ligand d’ADN-G4 peut donc être évalué
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Bertrand, Hélène. "Hétérocycles aromatiques étendus : variations structurales pour l'auto-assemblage bi-dimensionnel et la reconnaissance d'ADN G-quadruplexe." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2008. http://tel.archives-ouvertes.fr/tel-00343363.

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Dans ce travail de thèse, nous nous sommes intéressés à la synthèse et l'utilisation d'outils chimiques pour l'étude des interactions intermoléculaires dans le domaine des nanostructures et dans celui de la biologie.<br />Dans ce but, nous avons développé une famille de molécules, les triazatrinaphthylènes (TrisK), se caractérisant par un large coeur aromatique ainsi que par la diversité des chaînes latérales qui peuvent y être introduites, leur nature gouvernant le type d'application désirée.<br />L'introduction de chaînes lipophiles confère aux TrisKs des propriétés d'auto-assemblage sur des
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Bonnat, Laureen. "Synthèse et étude d'ADN et d'ARN G-quadruplexes à topologies contrôlées. Applications pour la caractérisation et la sélection de ligands." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV081/document.

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Les acides nucléiques riches en guanines ou en cytosines peuvent se replier sur eux-mêmes et former des systèmes tétramériques tels que les G-quadruplexes (G4) ou les i-motifs. Ces motifs, abondamment représentés dans certaines régions du génome humain semblent contribuer à la régulation cellulaire et suscitent depuis plusieurs années un intérêt grandissant. Ils sont notamment présents dans la région télomérique, mais aussi dans les promoteurs d’oncogènes ou au sein des génomes viraux et sont impliqués dans certaines pathologies humaines. Ils représentent ainsi des cibles thérapeutiques et dia
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Allain, Clémence. "Sondes fluorescentes pour l'ADN : marquages covalent et non-covalent." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2006. http://tel.archives-ouvertes.fr/tel-00202422.

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Le marquage fluorescent de biomolécules est devenu un outil incontournable en biologie. Dans ce contexte, nous avons conçu de nouvelles sondes fluorescentes pour l'ADN.<br />Le marquage non-covalent d'ADN quadruplexe (ADN-G4) par reconnaissance structurale a été étudié. Les propriétés mitigées des composés obtenus en conjuguant un ligand d'ADN-G4 à des sondes fluorescentes nous ont conduit à étudier le Thiazole Orange (TO), dont la fluorescence est exaltée par l'ADN. Le TO a une forte affinité pour l'ADN-G4, qui exalte fortement sa fluorescence. L'affinité d'un ligand d'ADN-G4 peut donc être é
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Audry, Julien. "Réplication et maintenance des télomères chez Schizosaccharomyces pombe : Rôle du complexe RPA dans la prévention ou la résolution de structures secondaires de type G-quadruplexes." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4013.

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Les télomères sont des structures nucléoprotéiques protégeant l’extrémité des chromosomes de la dégradation et assurant la réplication de l’ADN terminal. En effet, de nombreuses protéines de réplication sont impliquées dans le maintien de ces structures, comme le complexe RPA (Replication Protein A). Ce complexe très conservé chez les eucaryotes se fixe à l’ADN simple brin et est impliqué dans la réplication, les mécanismes de recombinaison et la réparation de l’ADN. Chez S.pombe, la mutation ponctuelle de la sous-unité RPA1 (Rpa1-D223Y) provoque le raccourcissement des télomères. Dans cette é
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Merle, Patrick. "Etude de ligands de l'ADN G-quadruplexe télomérique dans le traitement du glioblastome et cancer bronchique : approches combinatoires." Thesis, Clermont-Ferrand 1, 2011. http://www.theses.fr/2011CLF1MM14.

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Beauvarlet, Jennifer. "Caractérisation du rôle de la voie de réponse aux dommages à l'ADN et des lysosomes dans la mort cellulaire et la sénescence induites par un ligand G-quadruplexe." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0318.

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Les G-quadruplexes (G4) sont des structures non canoniques des acides nucléiques qui peuvent être formés dans des régions d’ADN ou d’ARN riches en guanines. Les ligands G4 (LG4), sont des molécules capables d’interagir et de stabiliser les structures G4, qui présentent de nombreuses propriétés anti-cancéreuses. Nous avons travaillé avec le LG4 20A, appartenant à la famille des triarylpyridines, qui stabilise efficacement les structures G4 in vitro. Les objectifs de ce travail ont été de déterminer les mécanismes moléculaires et cellulaires responsables des effets anti-prolifératifs du 20A dans
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Decorsière, Adrien. "Régulation de la maturation en 3' des pré-ARNm de gènes de susceptibilité aux cancers p53 et msh6." Toulouse 3, 2011. http://thesesups.ups-tlse.fr/1313/.

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La maturation en 3' des pré-ARNm constitue une étape de régulation posttranscriptionnelle indispensable à l'expression d'un gène. Elle est composée de deux réactions : le clivage de l'extrémité 3' qui permet de libérer l'ARNm du site de transcription et l'ajout de la queue poly(A) qui contrôle à la fois l'export nucléaire, la stabilité et la traduction du transcrit mature. Plusieurs études montrent, d'une part, que la maturation en 3' est inhibée de manière globale lors de dommages à l'ADN et d'autre part, que des dérégulations de cette maturation peuvent contribuer au développement tumoral. N
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Morel, Elodie. "Conception d’outils chimiques pour la détection des structures d’ADN G-quadruplex." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS237.

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Des structures secondaires d’acides nucléiques atypiques, les structures G-quadruplex, peuvent se former autour d’un cation (K+ ou Na+) dans les régions riches en guanines, grâce à une association de type Hoogsteen. La formation de ces structures est impliquée dans de nombreux mécanismes biologiques, comme la réplication, la transcription ou l’épissage. Elles peuvent affecter l’architecture de l’ADN jusqu’au niveau de la chromatine et provoquer une instabilité importante, tant génétique qu’épigénétique. De nombreuses méthodes ont été développées afin de détecter ces structures in vivo et de co
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Gros, Julien. "Quadruplexes de Guanines en ADN et en ARN." Paris 6, 2009. http://www.theses.fr/2009PA066054.

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Les quadruplexes de guanines (G4) sont des structures non canoniques d’acide nucléique formées à partir de séquences ADN ou ARN riches en guanines (G) et basées sur la formation puis l’empilement de G-quartets. D’un point de vue technologique, la formation de ces structures peut être imaginée dans de nombreux domaines d’application allant de la chimie supra-moléculaire aux nanotechnologies. In vivo, ces structures pourraient être impliquées de façon transitoire dans de nombreux processus biologiques, en particulier au niveau des télomères. Les travaux de thèse présentés dans ce manuscrit relèv
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Books on the topic "ADN quadruplexe"

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Dunmore, Helen. Bruder, Bruder, Schwester, Schwester: Roman. Beltz und Gelberg, 1999.

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Transition to global rivalry: Alliance diplomacy and the Quadruple Entente, 1895-1907. Cambridge University Press, 1995.

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Brother, brother, sister, sister. Scholastic, 1999.

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One of these things is not like the other. Suspect Thoughts Press, 2005.

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The Cunard turbine-driven quadruple-screw Atlantic liner, Mauretania. Patrick Stephens, 1987.

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Dunmore, Helen. Bruder, Bruder, Schwester, Schwester. Beltz, 2001.

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Brother Brother, Sister Sister. Tandem Library, 2000.

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(Narrator), Eve Karpf, ed. Brother Brother, Sister Sister. Chivers Children's Audio Books, 2000.

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Brother Brother, Sister Sister. Apple Signature (Scholastic), 2000.

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Brother Brother, Sister Sister. Scholastic Press, 2001.

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Book chapters on the topic "ADN quadruplexe"

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Weik, Martin H. "quadruplex system." In Computer Science and Communications Dictionary. Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_15205.

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Weik, Martin H. "quadruple." In Computer Science and Communications Dictionary. Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_15197.

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Mathad, Raveendra I., and Danzhou Yang. "G-Quadruplex Structures and G-Quadruplex-Interactive Compounds." In Telomeres and Telomerase. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-092-8_8.

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Halder, Kangkan, and Jörg S. Hartig. "4. RNA Quadruplexes." In Structural and Catalytic Roles of Metal Ions in RNA. Royal Society of Chemistry, 2011. http://dx.doi.org/10.1039/9781849732512-00125.

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Weik, Martin H. "quadruple-address." In Computer Science and Communications Dictionary. Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_15198.

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Weik, Martin H. "quadruple diversity." In Computer Science and Communications Dictionary. Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_15200.

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Weik, Martin H. "quadruple register." In Computer Science and Communications Dictionary. Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_15204.

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Lin, Clement, and Danzhou Yang. "Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds." In Telomeres and Telomerase. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6892-3_17.

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De Boer, W. A. "Quadruple Therapy." In Clinical Pharmacology and Therapy of Helicobacter pylori Infection. KARGER, 1999. http://dx.doi.org/10.1159/000061967.

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de Boer, W. A. "Quadruple Therapy." In Clinical Pharmacology and Therapy of Helicobacter pylori Infection. KARGER, 2004. http://dx.doi.org/10.1159/000077624.

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Conference papers on the topic "ADN quadruplexe"

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He, Jun, and Ying Zhu. "Design and Implementation of a Quadruple Floating-point Fused Multiply-Add Unit." In 2nd International Conference on Computer Science and Electronics Engineering (ICCSEE 2013). Atlantis Press, 2013. http://dx.doi.org/10.2991/iccsee.2013.438.

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Rekha, K. "Design of quadruple band antenna operating at quadruple frequencies." In 2016 International Conference on Communication and Signal Processing (ICCSP). IEEE, 2016. http://dx.doi.org/10.1109/iccsp.2016.7754324.

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Rüütmann, Tiia. "ENGINEERING PEDAGOGY SCIENCE AS THE CONTEMPORARY BASIS FOR EFFECTIVE TEACHING OF SCIENCE, TECHNOLOGY AND ENGINEERING." In 3rd International Baltic Symposium on Science and Technology Education (BalticSTE2019). Scientia Socialis Ltd., 2019. http://dx.doi.org/10.33225/balticste/2019.187.

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This study is introducing the basic principles of Engineering Pedagogy Science for effective design, teaching and learning of science, technology and engineering. The basic didactical models are introduced for contemporary design of effective teaching and learning. A quadruple instruction model of Engineering Pedagogy Science is proposed, integrating the principles of Behaviourism, Cognitivism, Social Constructivism and Humanism on the basis of didactic model of Engineering Pedagogy Science. Keywords: didactical model, effective teaching of STE, engineering pedagogy, educational design, quadru
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Doluca, Osman. "Relaxed formation rules for G-quadruplex prediction." In 2018 26th Signal Processing and Communications Applications Conference (SIU). IEEE, 2018. http://dx.doi.org/10.1109/siu.2018.8404537.

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Iloanusi, Ogechukwu, Aglika Gyaourova, and Arun Ross. "Indexing fingerprints using minutiae quadruplets." In 2011 IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops (CVPR Workshops). IEEE, 2011. http://dx.doi.org/10.1109/cvprw.2011.5981825.

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Gokkavas, Mutlu, Serkan Butun, Piotr Caban, Wlodek Strupinski, and Ekmel Ozbay. "AlGaN quadruple-band photodetectors." In LEOS 2009 -22nd Annuall Meeting of the IEEE Lasers and Electro-Optics Society. LEO 2009. IEEE, 2009. http://dx.doi.org/10.1109/leos.2009.5343098.

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Ho, Phay J., and Joseph H. Eberly. "Classical Non-Sequential Quadruple Ionization." In Organic Photonics and Electronics. OSA, 2006. http://dx.doi.org/10.1364/ope.2006.pdp_fa4.

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Jun, He, Wang Biao, and Zhu Ying. "Design of a Quadruple Precision Floating-Point Fused Multiply-Add Unit Based on 4-Way SIMD Device." In 2013 IEEE 8th International Conference on Networking, Architecture, and Storage (NAS). IEEE, 2013. http://dx.doi.org/10.1109/nas.2013.42.

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Oneill, Peter, Nell Kimberley, and Chih Wei Teng. "Public University Models for Education – from Innovation to Entrepreneurship." In Third International Conference on Higher Education Advances. Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/head17.2017.5281.

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The management of Australian public universities has changed dramatically over the last two decades with the decrease in public funding across teaching and research sectors. This has forced a strategic repositioning of universities and likewise a rethink on value generation and its translation into various revenue streams. The aim of this paper is to provide an analysis of current government innovation policy and university capabilities to support the translation of innovation, and in so doing explore the possibilities of a Quadruple Helix innovation approach to building new models for educati
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Zhu, Fang, and Guoqing Luo. "A W-Band Frequency Quadrupler MMIC." In 2020 International Conference on Microwave and Millimeter Wave Technology (ICMMT). IEEE, 2020. http://dx.doi.org/10.1109/icmmt49418.2020.9386556.

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Reports on the topic "ADN quadruplexe"

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Ebbinghaus, Scot W. Evaluation of the G-quadruplex Binding Drug Telomestatin as an Inhibitor of c-myb in Chronic Myelogenous Leukemia. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada587004.

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Ebbinghaus, Scot W. Evaluation of the G-quadruplex Binding Drug Telomestatin as an Inhibitor of c-myb in Chronic Myelogenous Leukemia. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada593319.

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