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Journal articles on the topic 'ADN quadruplexe'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

Koralewska, Natalia, Agnieszka Szczepanska, Kinga Ciechanowska, et al. "RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity." Cellular and Molecular Life Sciences 78, no. 7 (2021): 3709–24. http://dx.doi.org/10.1007/s00018-021-03795-w.

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AbstractGuanine (G)-rich single-stranded nucleic acids can adopt G-quadruplex structures. Accumulating evidence indicates that G-quadruplexes serve important regulatory roles in fundamental biological processes such as DNA replication, transcription, and translation, while aberrant G-quadruplex formation is linked to genome instability and cancer. Understanding the biological functions played by G-quadruplexes requires detailed knowledge of their protein interactome. Here, we report that both RNA and DNA G-quadruplexes are bound by human Dicer in vitro. Using in vitro binding assays, mutation

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2

Sanchez-Martin, Victoria, Carmen Lopez-Pujante, Miguel Soriano-Rodriguez, and Jose A. Garcia-Salcedo. "An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer." International Journal of Molecular Sciences 21, no. 23 (2020): 8900. http://dx.doi.org/10.3390/ijms21238900.

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Non-canonical, four-stranded nucleic acids secondary structures are present within regulatory regions in the human genome and transcriptome. To date, these quadruplex structures include both DNA and RNA G-quadruplexes, formed in guanine-rich sequences, and i-Motifs, found in cytosine-rich sequences, as their counterparts. Quadruplexes have been extensively associated with cancer, playing an important role in telomere maintenance and control of genetic expression of several oncogenes and tumor suppressors. Therefore, quadruplex structures are considered attractive molecular targets for cancer t

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3

Savva, Loukiani, and Savvas N. Georgiades. "Recent Developments in Small-Molecule Ligands of Medicinal Relevance for Harnessing the Anticancer Potential of G-Quadruplexes." Molecules 26, no. 4 (2021): 841. http://dx.doi.org/10.3390/molecules26040841.

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G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in recent years as novel targets, with untapped potential for anticancer research. Their potential stems from the fact that G-quadruplexes occur in functionally-important regions of the human genome, such as the telomere tandem sequences, several proto-oncogene promoters, other regulatory regions and sequences of DNA (e.g., rDNA), as well as in mRNAs encoding for proteins with roles in tumorigenesis. Modulation of G-quadruplexes, via interaction with high-affinity ligands, leads to their stabilization, with num

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4

Kotkowiak, Weronika, and Anna Pasternak. "Beyond G-Quadruplexes—The Effect of Junction with Additional Structural Motifs on Aptamers Properties." International Journal of Molecular Sciences 22, no. 18 (2021): 9948. http://dx.doi.org/10.3390/ijms22189948.

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G-quadruplexes constitute an important type of nucleic acid structure, which can be found in living cells and applied by cell machinery as pivotal regulatory elements. Importantly, robust development of SELEX technology and modern, nucleic acid-based therapeutic strategies targeted towards various molecules have also revealed a large group of potent aptamers whose structures are grounded in G-quadruplexes. In this review, we analyze further extension of tetraplexes by additional structural elements and investigate whether G-quadruplex junctions with duplex, hairpin, triplex, or second G-quadru

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Nowak-Karnowska, Joanna, Agata Głuszyńska, Joanna Kosman, Grażyna Neunert, and Anna Dembska. "Interaction of 9-Methoxyluminarine with Different G-Quadruplex Topologies: Fluorescence and Circular Dichroism Studies." International Journal of Molecular Sciences 22, no. 19 (2021): 10399. http://dx.doi.org/10.3390/ijms221910399.

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The interactions of G–quadruplexes of different topologies with highly fluorescent 9-methoxyluminarine ligand 9-MeLM were investigated by fluorescence and circular dichroism spectroscopy. The results showed that 9-methoxyluminarine was able to interact and did not destabilize any investigated molecular targets. The studied compound was selectively quenched by parallel c-MYC G-quadruplex DNA, whereas hybrid and antiparallel G4 topology caused only a negligible decrease in the fluorescence of the ligand. A high decrease of fluorescence of the ligand after binding with c-MYC G-quadruplex suggests

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6

Lauria, Antonino, Gabriele La Monica, Alessio Terenzi, et al. "Antiproliferative Properties and G-Quadruplex-Binding of Symmetrical Naphtho[1,2-b:8,7-b’]dithiophene Derivatives." Molecules 26, no. 14 (2021): 4309. http://dx.doi.org/10.3390/molecules26144309.

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Background: G-quadruplex (G4) forming sequences are recurrent in telomeres and promoter regions of several protooncogenes. In normal cells, the transient arrangements of DNA in G-tetrads may regulate replication, transcription, and translation processes. Tumors are characterized by uncontrolled cell growth and tissue invasiveness and some of them are possibly mediated by gene expression involving G-quadruplexes. The stabilization of G-quadruplex sequences with small molecules is considered a promising strategy in anticancer targeted therapy. Methods: Molecular virtual screening allowed us iden

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7

Bizyaeva, Anastasia A., Dmitry A. Bunin, Valeria L. Moiseenko, et al. "The Functional Role of Loops and Flanking Sequences of G-Quadruplex Aptamer to the Hemagglutinin of Influenza a Virus." International Journal of Molecular Sciences 22, no. 5 (2021): 2409. http://dx.doi.org/10.3390/ijms22052409.

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Nucleic acid aptamers are generally accepted as promising elements for the specific and high-affinity binding of various biomolecules. It has been shown for a number of aptamers that the complexes with several related proteins may possess a similar affinity. An outstanding example is the G-quadruplex DNA aptamer RHA0385, which binds to the hemagglutinins of various influenza A virus strains. These hemagglutinins have homologous tertiary structures but moderate-to-low amino acid sequence identities. Here, the experiment was inverted, targeting the same protein using a set of related, parallel G

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8

Volná, Adriana, Martin Bartas, Václav Karlický, et al. "G-Quadruplex in Gene Encoding Large Subunit of Plant RNA Polymerase II: A Billion-Year-Old Story." International Journal of Molecular Sciences 22, no. 14 (2021): 7381. http://dx.doi.org/10.3390/ijms22147381.

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G-quadruplexes have long been perceived as rare and physiologically unimportant nucleic acid structures. However, several studies have revealed their importance in molecular processes, suggesting their possible role in replication and gene expression regulation. Pathways involving G-quadruplexes are intensively studied, especially in the context of human diseases, while their involvement in gene expression regulation in plants remains largely unexplored. Here, we conducted a bioinformatic study and performed a complex circular dichroism measurement to identify a stable G-quadruplex in the gene

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9

Novotný, Jan, Yevgen P. Yurenko, Petr Kulhánek, and Radek Marek. "Tailoring the properties of quadruplex nucleobases for biological and nanomaterial applications." Phys. Chem. Chem. Phys. 16, no. 29 (2014): 15241–48. http://dx.doi.org/10.1039/c4cp00541d.

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10

Raguseo, Federica, Souroprobho Chowdhury, Aisling Minard, and Marco Di Antonio. "Chemical-biology approaches to probe DNA and RNA G-quadruplex structures in the genome." Chemical Communications 56, no. 9 (2020): 1317–24. http://dx.doi.org/10.1039/c9cc09107f.

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G-quadruplexes are nucleic-acids secondary structures that can be formed under physiological conditions. In this review, we critically present the most relevant chemical-biology methods to probe the biological functions of G-quadruplex structures.

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11

Clua, Anna, Carme Fàbrega, Jesús García-Chica, Santiago Grijalvo, and Ramon Eritja. "Parallel G-quadruplex Structures Increase Cellular Uptake and Cytotoxicity of 5-Fluoro-2′-deoxyuridine Oligomers in 5-Fluorouracil Resistant Cells." Molecules 26, no. 6 (2021): 1741. http://dx.doi.org/10.3390/molecules26061741.

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Fluoropyrimidines, such as 5-fluorouracil (5-FU) and related prodrugs have been considered first-line chemotherapy agents for the treatment of colorectal cancer. However, poor specificity and tumor cell resistance remain major limiting bottlenecks. G-quadruplexes, have been suggested as preferred nanostructures for enhancing cellular uptake mediated by G-quadruplex binding proteins which are abundant at the membranes of some tumor cells. In the current study, we propose a new strategy to deliver 5-fluoro-2′-deoxyuridine (5-FdU) monophosphate, the main active drug from 5-FU derivatives that may

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12

Singh, Kukreti, Saso, and Kukreti. "Oxidative Stress: Role and Response of Short Guanine Tracts at Genomic Locations." International Journal of Molecular Sciences 20, no. 17 (2019): 4258. http://dx.doi.org/10.3390/ijms20174258.

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Over the decades, oxidative stress has emerged as a major concern to biological researchers. It is involved in the pathogenesis of various lifestyle-related diseases such as hypertension, diabetes, atherosclerosis, and neurodegenerative diseases. The connection between oxidative stress and telomere shortening via oxidative guanine lesion is well documented. Telomeres are confined to guanine rich ends of chromosomes. Owing to its self-association properties, it adopts G-quadruplex structures and hampers the overexpression of telomerase in the cancer cells. Guanine, being the most oxidation pron

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13

Minard, Aisling, Danielle Morgan, Federica Raguseo, et al. "A short peptide that preferentially binds c-MYC G-quadruplex DNA." Chemical Communications 56, no. 63 (2020): 8940–43. http://dx.doi.org/10.1039/d0cc02954h.

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G-quadruplexes are nucleic-acids secondary structures that are highly abundant in the human genome. In this work,we identified a short-peptide that displays selectivity for the G-quadruplex formed in the promoter region of the oncogene c-MYC.

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14

Potrč, Melani, Nerea Sebastián, Miha Škarabot, Irena Drevenšek-Olenik, and Lea Spindler. "Supramolecular Polymorphism of (G4C2)n Repeats Associated with ALS and FTD." International Journal of Molecular Sciences 22, no. 9 (2021): 4532. http://dx.doi.org/10.3390/ijms22094532.

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Guanine-rich DNA sequences self-assemble into highly stable fourfold structures known as DNA-quadruplexes (or G-quadruplexes). G-quadruplexes have furthermore the tendency to associate into one-dimensional supramolecular aggregates termed G-wires. We studied the formation of G-wires in solutions of the sequences d(G4C2)n with n = 1, 2, and 4. The d(G4C2)n repeats, which are associated with some fatal neurological disorders, especially amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), represent a challenging research topic due to their extensive structural polymorphism. We

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15

Alessandrini, Irene, Marta Recagni, Nadia Zaffaroni, and Marco Folini. "On the Road to Fight Cancer: The Potential of G-Quadruplex Ligands as Novel Therapeutic Agents." International Journal of Molecular Sciences 22, no. 11 (2021): 5947. http://dx.doi.org/10.3390/ijms22115947.

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Nucleic acid sequences able to adopt a G-quadruplex conformation are overrepresented within the human genome. This evidence strongly suggests that these genomic regions have been evolutionary selected to play a pivotal role in several aspects of cell biology. In the present review article, we provide an overview on the biological impact of targeting G-quadruplexes in cancer. A variety of small molecules showing good G-quadruplex stabilizing properties has been reported to exert an antitumor activity in several preclinical models of human cancers. Moreover, promiscuous binders and multiple targ

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16

Azargun, M., Y. Jami-Alahmadi, and T. D. Fridgen. "The intrinsic stabilities and structures of alkali metal cationized guanine quadruplexes." Physical Chemistry Chemical Physics 19, no. 2 (2017): 1281–87. http://dx.doi.org/10.1039/c6cp07301h.

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The structures and stabilities of self-assembled guanine quadruplexes, M(9eG)<sub>8</sub><sup>+</sup> (M = Na, K, Rb, Cs; 9eG = 9-ethylguanine), have been studied in the gas phase by blackbody infrared radiative dissociation kinetics to determine the effect the metal cations have on the decomposition energies and reactions of the quadruplex.

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17

Krafčík, Daniel, Eva Ištvánková, Šimon Džatko, Pavlína Víšková, Silvie Foldynová-Trantírková, and Lukáš Trantírek. "Towards Profiling of the G-Quadruplex Targeting Drugs in the Living Human Cells Using NMR Spectroscopy." International Journal of Molecular Sciences 22, no. 11 (2021): 6042. http://dx.doi.org/10.3390/ijms22116042.

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Recently, the 1H-detected in-cell NMR spectroscopy has emerged as a unique tool allowing the characterization of interactions between nucleic acid-based targets and drug-like molecules in living human cells. Here, we assess the application potential of 1H and 19F-detected in-cell NMR spectroscopy to profile drugs/ligands targeting DNA G-quadruplexes, arguably the most studied class of anti-cancer drugs targeting nucleic acids. We show that the extension of the original in-cell NMR approach is not straightforward. The severe signal broadening and overlap of 1H in-cell NMR spectra of polymorphic

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18

König, Sebastian L. B., Amanda C. Evans, and Julian L. Huppert. "Seven essential questions on G-quadruplexes." BioMolecular Concepts 1, no. 2 (2010): 197–213. http://dx.doi.org/10.1515/bmc.2010.011.

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AbstractThe helical duplex architecture of DNA was discovered by Francis Crick and James Watson in 1951 and is well known and understood. However, nucleic acids can also adopt alternative structural conformations that are less familiar, although no less biologically relevant, such as the G-quadruplex. G-quadruplexes continue to be the subject of a rapidly expanding area of research, owing to their significant potential as therapeutic targets and their unique biophysical properties. This review begins by focusing on G-quadruplex structure, elucidating the intermolecular and intramolecular inter

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19

Adeoye, Raphael I., Dunsin S. Osalaye, Theresia K. Ralebitso-Senior, et al. "Catalytic Activities of Multimeric G-Quadruplex DNAzymes." Catalysts 9, no. 7 (2019): 613. http://dx.doi.org/10.3390/catal9070613.

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G-quadruplex DNAzymes are short DNA aptamers with repeating G4 quartets bound in a non-covalent complex with hemin. These G4/Hemin structures exhibit versatile peroxidase-like catalytic activity with a wide range of potential applications in biosensing and biotechnology. Current efforts are aimed at gaining a better understanding of the molecular mechanism of DNAzyme catalysis as well as devising strategies for improving their catalytic efficiency. Multimerisation of discrete units of G-quadruplexes to form multivalent DNAzyes is an emerging design strategy aimed at enhancing the peroxidase ac

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20

Desai, Nakshi, Viraj Shah, and Bhaskar Datta. "Assessing G4-Binding Ligands In Vitro and in Cellulo Using Dimeric Carbocyanine Dye Displacement Assay." Molecules 26, no. 5 (2021): 1400. http://dx.doi.org/10.3390/molecules26051400.

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G-quadruplexes (G4) are the most actively studied non-canonical secondary structures formed by contiguous repeats of guanines in DNA or RNA strands. Small molecule mediated targeting of G-quadruplexes has emerged as an attractive tool for visualization and stabilization of these structures inside the cell. Limited number of DNA and RNA G4-selective assays have been reported for primary ligand screening. A combination of fluorescence spectroscopy, AFM, CD, PAGE, and confocal microscopy have been used to assess a dimeric carbocyanine dye B6,5 for screening G4-binding ligands in vitro and in cell

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21

Bednářová, Klára, Michaela Vorlíčková, and Daniel Renčiuk. "Diversity of Parallel Guanine Quadruplexes Induced by Guanine Substitutions." International Journal of Molecular Sciences 21, no. 17 (2020): 6123. http://dx.doi.org/10.3390/ijms21176123.

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Recently, we reported an inhibitory effect of guanine substitutions on the conformational switch from antiparallel to parallel quadruplexes (G4) induced by dehydrating agents. As a possible cause, we proposed a difference in the sensitivity of parallel and antiparallel quadruplexes to the guanine substitutions in the resulting thermodynamic stability. Reports on the influence of guanine substitutions on the biophysical properties of intramolecular parallel quadruplexes are rare. Moreover, such reports are often complicated by the multimerisation tendencies of parallel quadruplexes. To address

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22

Reina, Chiara, and Vincenzo Cavalieri. "Epigenetic Modulation of Chromatin States and Gene Expression by G-Quadruplex Structures." International Journal of Molecular Sciences 21, no. 11 (2020): 4172. http://dx.doi.org/10.3390/ijms21114172.

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G-quadruplexes are four-stranded helical nucleic acid structures formed by guanine-rich sequences. A considerable number of studies have revealed that these noncanonical structural motifs are widespread throughout the genome and transcriptome of numerous organisms, including humans. In particular, G-quadruplexes occupy strategic locations in genomic DNA and both coding and noncoding RNA molecules, being involved in many essential cellular and organismal functions. In this review, we first outline the fundamental structural features of G-quadruplexes and then focus on the concept that these DNA

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23

Popenda, Mariusz, Joanna Miskiewicz, Joanna Sarzynska, Tomasz Zok, and Marta Szachniuk. "Topology-based classification of tetrads and quadruplex structures." Bioinformatics 36, no. 4 (2019): 1129–34. http://dx.doi.org/10.1093/bioinformatics/btz738.

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Abstract Motivation Quadruplexes attract the attention of researchers from many fields of bio-science. Due to a specific structure, these tertiary motifs are involved in various biological processes. They are also promising therapeutic targets in many strategies of drug development, including anticancer and neurological disease treatment. The uniqueness and diversity of their forms cause that quadruplexes show great potential in novel biological applications. The existing approaches for quadruplex analysis are based on sequence or 3D structure features and address canonical motifs only. Result

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24

Imperatore, Concetta, Antonio Varriale, Elisa Rivieccio, et al. "Spectroscopic Properties of Two 5′-(4-Dimethylamino)Azobenzene Conjugated G-Quadruplex Forming Oligonucleotides." International Journal of Molecular Sciences 21, no. 19 (2020): 7103. http://dx.doi.org/10.3390/ijms21197103.

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The synthesis of two 5′-end (4-dimethylamino)azobenzene conjugated G-quadruplex forming aptamers, the thrombin binding aptamer (TBA) and the HIV-1 integrase aptamer (T30695), was performed. Their structural behavior was investigated by means of UV, CD, fluorescence spectroscopy, and gel electrophoresis techniques in K+-containing buffers and water-ethanol blends. Particularly, we observed that the presence of the 5′-(4-dimethylamino)azobenzene moiety leads TBA to form multimers instead of the typical monomolecular chair-like G-quadruplex and almost hampers T30695 G-quadruplex monomers to dimer

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25

Li, Na, Ya Gao, Feng Qiu, and Tong Zhu. "Benchmark Force Fields for the Molecular Dynamic Simulation of G-Quadruplexes." Molecules 26, no. 17 (2021): 5379. http://dx.doi.org/10.3390/molecules26175379.

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G-quadruplexes have drawn widespread attention for serving as a potential anti-cancer target and their application in material science. Molecular dynamics (MD) simulation is the key theoretical tool in the study of GQ’s structure-function relationship. In this article, we systematically benchmarked the five force fields of parmbsc0, parmbsc1, OL15, AMOEBA, and Drude2017 on the MD simulation of G-quadruplex from four aspects: structural stability, central ion channel stability, description of Hoogsteen hydrogen bond network, and description of the main chain dihedral angle. The results show tha

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Virgilio, Antonella, Daniela Benigno, Annalisa Pecoraro, et al. "Exploring New Potential Anticancer Activities of the G-Quadruplexes Formed by [(GTG2T(G3T)3] and Its Derivatives with an Abasic Site Replacing Single Thymidine." International Journal of Molecular Sciences 22, no. 13 (2021): 7040. http://dx.doi.org/10.3390/ijms22137040.

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In this paper, we report our investigations on five T30175 analogues, prepared by replacing sequence thymidines with abasic sites (S) one at a time, in comparison to their natural counterpart in order to evaluate their antiproliferative potential and the involvement of the residues not belonging to the central core of stacked guanosines in biological activity. The collected NMR (Nuclear Magnetic Resonance), CD (Circular Dichroism), and PAGE (Polyacrylamide Gel Electrophoresis) data strongly suggest that all of them adopt G-quadruplex (G4) structures strictly similar to that of the parent aptam

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27

Kolganova, Natalia A., Anna M. Varizhuk, Roman A. Novikov, et al. "Anomeric DNA quadruplexes." Artificial DNA: PNA & XNA 5, no. 2 (2014): e28422. http://dx.doi.org/10.4161/adna.28422.

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28

Huppert, Julian Leon. "Four-stranded DNA: cancer, gene regulation and drug development." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 365, no. 1861 (2007): 2969–84. http://dx.doi.org/10.1098/rsta.2007.0011.

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DNA can form many structures other than the famous double helix. In particular, guanine-rich DNA of particular sequences can form four-stranded structures, called G-quadruplexes. This article describes the structural form of these sequences, techniques for predicting which sequences can fold up in this manner and efforts towards stability prediction. It then discusses the biological significance of these structures, focusing on their importance in telomeric regions at the end of chromosomes, and their existence in gene promoters and mRNA, where they may be involved with regulating transcriptio

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Xu, Jin, Zhi-Yu Chen, and Yin-Xia Zhu. "Dual-Plane Quadruplexer Using Common Lumped-Element Quadruple-Mode Resonator." IEEE Microwave and Wireless Components Letters 29, no. 9 (2019): 617–19. http://dx.doi.org/10.1109/lmwc.2019.2930683.

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Mukundan, Vineeth Thachappilly, and Anh Tuân Phan. "Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences." Journal of the American Chemical Society 135, no. 13 (2013): 5017–28. http://dx.doi.org/10.1021/ja310251r.

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31

Tomaszewska, Maria, Marta Szabat, Karolina Zielińska, and Ryszard Kierzek. "Identification and Structural Aspects of G-Quadruplex-Forming Sequences from the Influenza A Virus Genome." International Journal of Molecular Sciences 22, no. 11 (2021): 6031. http://dx.doi.org/10.3390/ijms22116031.

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Influenza A virus (IAV) causes seasonal epidemics and sporadic pandemics, therefore is an important research subject for scientists around the world. Despite the high variability of its genome, the structure of viral RNA (vRNA) possesses features that remain constant between strains and are biologically important for virus replication. Therefore, conserved structural motifs of vRNA can represent a novel therapeutic target. Here, we focused on the presence of G-rich sequences within the influenza A/California/07/2009(H1N1) genome and their ability to form RNA G-quadruplex structures (G4s). We i

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Kalashnikov, S. A., and D. R. Kudratova. "Perinatal outcomes of quadruplet pregnancy." Obstetrics, Gynecology and Reproduction 15, no. 4 (2021): 371–78. http://dx.doi.org/10.17749/2313-7347/ob.gyn.rep.2020.211.

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Introduction. A significantly increased frequency of multiple pregnancies including more than two fetuses is a consequence of using assisted reproductive technologies and ovulation stimulations. However, such pregnancies remain poorly investigated. Aim: to study the course and perinatal outcomes of quadruplet pregnancies.Materials and Methods. 7 pregnant women with quadruplets were examined. A comprehensive examination, including fetometry, monitoring of the cervical length, Doppler examination, and treatment of all complications were performed for all pregnant women. Results. Quadruplet pregn

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Hughes, Natalie, Nancy Nguyen, Deanna-Kaye Daley, Justin Grennell, Amira Gee, and Mehnaaz F. Ali. "Comparison of DNAzyme activity for the development of an immobilized heme sensor." MRS Advances 3, no. 26 (2018): 1491–96. http://dx.doi.org/10.1557/adv.2017.637.

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ABSTRACTPoint-of-care systems require highly sensitive, quantitative and selective detection platforms for the real-time multiplexed monitoring of target analytes. To ensure facile development of a sensor, it is preferable for the detection assay to have minimal chemical complexity, contain no wash steps and provide a wide and easily adaptable detection range for multiple targets. Current studies involve label-free detection strategy for relevant clinical molecules such as heme using G-quadruplex based self-assembly. We have explored the measurement of binding and kinetic parameters of various

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Imaizumi, Yoko. "Estimated Number of Multiplets Under 16 Years Using Two Sets of Census Data in Japan: 1990 and 1995." Twin Research 4, no. 4 (2001): 232–37. http://dx.doi.org/10.1375/twin.4.4.232.

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AbstractData for sets of multiples under 16 years of age were obtained from the population censuses of Japan in 1990 and 1995. These numbered 147,188 twin pairs, 1410 sets of triplets, 59 sets of quadruplets, and 3 sets of quintuplets in 1990, with the corresponding numbers in 1995 being 141,354, 2,211, 136 and 12, respectively. The total number of sets of multiples was 148,660 in 1990 and 143,713 in 1995. Twinning, triplet, quadruplet and quintuplet rates were estimated for each age. Rates of monozygotic twins and triplets remained constant age by age up to 15 years, while the dizygotic twinn

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Nguyen, Thi Quynh Ngoc, Kah Wai Lim, and Anh Tuân Phan. "Folding Kinetics of G-Quadruplexes: Duplex Stem Loops Drive and Accelerate G-Quadruplex Folding." Journal of Physical Chemistry B 124, no. 25 (2020): 5122–30. http://dx.doi.org/10.1021/acs.jpcb.0c02548.

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36

Lo Faro, Giovanni. "Steiner quadruple systems having a prescribed number of quadruples in common." Discrete Mathematics 58, no. 2 (1986): 167–74. http://dx.doi.org/10.1016/0012-365x(86)90159-7.

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Kosman, Joanna, and Bernard Juskowiak. "Thrombin-Binding Aptamer with Inversion of Polarity Sites (IPS): Effect on DNAzyme Activity and Anticoagulant Properties." International Journal of Molecular Sciences 22, no. 15 (2021): 7902. http://dx.doi.org/10.3390/ijms22157902.

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In this work we examined the properties of thrombin-binding aptamer (TBA) modified by the introduction of inversion of polarity sites (IPS) in order to assess the effect of modification on the activation of TBA to serve as DNAzyme with peroxidase-like activity. Two oligonucleotides were designed to possess one (IPS1) or three (IPS2) inversion sites. TBA typically forms antiparallel G-quadruplexes with two G-tetrads, which exhibits very low DNAzyme peroxidise activity. DNAzyme activity is generally attributed to parallel G-quadruplexes. Hence, inversion of polarity was introduced in the TBA mol

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Li, Fuhong, Yuejia Luo, Bihua Cao, and Hong Li. "Electrophysiological Correlates of Inductive Generalization." Journal of Psychophysiology 23, no. 1 (2009): 27–34. http://dx.doi.org/10.1027/0269-8803.23.1.27.

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The cognitive mechanism of inductive generalization has been studied broadly, although the neural correlates are still unclear. In the present study, participants were provided with battery quadruplets. Within each quadruplet, some batteries were charged while others were not. Participants were asked to generate a hypothesis about what kinds of batteries were charged. The results revealed that the reaction times and the latencies of frontal N1 were shorter in the Generalizable condition than in the Nongeneralizable condition. After 420 ms onset of stimuli, the late positive complex (LPC) was i

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Jiang, Dongneng, Fei Liu, Liqun Zhang, Linlin Liu, Chang Liu, and Xiaoyun Pu. "An electrochemical strategy with molecular beacon and hemin/G-quadruplex for the detection of Clostridium perfringens DNA on screen-printed electrodes." RSC Adv. 4, no. 100 (2014): 57064–70. http://dx.doi.org/10.1039/c4ra09834j.

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G, Monisha, and Savitha S. "Fractional Quadruple Laplace Transform and its Properties." International Journal of Trend in Scientific Research and Development Volume-2, Issue-5 (2018): 2404–9. http://dx.doi.org/10.31142/ijtsrd18280.

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Srinivasan, Anitha. "D(-1)-quadruples and products of two primes." Glasnik Matematicki 50, no. 2 (2015): 261–68. http://dx.doi.org/10.3336/gm.50.2.01.

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Labudová, Dominika, Jiří Hon, and Matej Lexa. "pqsfinder web: G-quadruplex prediction using optimized pqsfinder algorithm." Bioinformatics 36, no. 8 (2019): 2584–86. http://dx.doi.org/10.1093/bioinformatics/btz928.

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Abstract Motivation G-quadruplex is a DNA or RNA form in which four guanine-rich regions are held together by base pairing between guanine nucleotides in coordination with potassium ions. G-quadruplexes are increasingly seen as a biologically important component of genomes. Their detection in vivo is problematic; however, sequencing and spectrometric techniques exist for their in vitro detection. We previously devised the pqsfinder algorithm for PQS identification, implemented it in C++ and published as an R/Bioconductor package. We looked for ways to optimize pqsfinder for faster and user-fri

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Yu, Guojun, Yingru Wu, Zhi Duan, et al. "A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes." PLOS Computational Biology 17, no. 9 (2021): e1009323. http://dx.doi.org/10.1371/journal.pcbi.1009323.

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The B cells in our body generate protective antibodies by introducing somatic hypermutations (SHM) into the variable region of immunoglobulin genes (IgVs). The mutations are generated by activation induced deaminase (AID) that converts cytosine to uracil in single stranded DNA (ssDNA) generated during transcription. Attempts have been made to correlate SHM with ssDNA using bisulfite to chemically convert cytosines that are accessible in the intact chromatin of mutating B cells. These studies have been complicated by using different definitions of “bisulfite accessible regions” (BARs). Recently

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Strauss, Alexander, Ivo M. Heer, Udo Janßen, Christian Dannecker, Peter Hillemanns, and Susanne Müller-Egloff. "Routine Cervical Cerclage in Higher Order Multiple Gestation — Does It Prolong the Pregnancy?" Twin Research 5, no. 2 (2002): 67–70. http://dx.doi.org/10.1375/twin.5.2.67.

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AbstractPreterm birth following cervical dilatation is the greatest threat to infants of a multiple pregnancy. Lacking reliable data concerning the effect of prophylactic cerclage, we compared a study group to controls for maternal and perinatal outcome. Sixteen of 94 triplet-, 9 of 18 quadruplet/quintuplet-pregnancies, treated with prophylactic cerclage, were retrospectively compared to those without cervical cerclage respectively. Kruskal-Wallis test and Mann-Whitney-U test were performed as non-parametric one way analysis of variance. For the analysis of frequencies Chi Square test or Fishe

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Irmak, Nurettin, and László Szalay. "Diophantine triples and reduced quadruples with the Lucas sequence of recurrence un=Aun-1-un-2." Glasnik Matematicki 49, no. 2 (2014): 303–12. http://dx.doi.org/10.3336/gm.49.2.05.

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Kiely, John L., and Michele Kiely. "Epidemiological trends in multiple births in the United States, 1971–1998." Twin Research 4, no. 3 (2001): 131–33. http://dx.doi.org/10.1375/twin.4.3.131.

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AbstractThe astounding rise in multiple births in the United States continues. We analyzed live birth files from the U.S. National Center for Health Statistics. Twin, triplet, quadruplet, and quintuplet+ rates were calculated for the period 1971–1977 and for each year between 1990 and 1998. Triplet rates were also computed within categories of mother's education and age. The twin rate increased from 1.8% in 1971–77 to 2.8% in 1998. The rate of triplets increased 5.9-fold, quadruplets 11.9-fold, and quintuplets+ 5.3-fold between 1971–77 and 1998. Increases in triplet rates were much more marked

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Mezei, Mihaly. "Exploiting Sparse Statistics for a Sequence-Based Prediction of the Effect of Mutations." Algorithms 12, no. 10 (2019): 214. http://dx.doi.org/10.3390/a12100214.

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Recent work showed that there is a significant difference between the statistics of amino acid triplets and quadruplets in sequences of folded proteins and randomly generated sequences. These statistics were used to assign a score to each sequence and make a prediction whether a sequence is likely to fold. The present paper extends the statistics to higher multiplets and suggests a way to handle the treatment of multiplets that were not found in the set of folded proteins. In particular, foldability predictions were done along the line of the previous work using pentuplet statistics and a way

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Zhang, Rongxin, Yajun Liu, Xingxing Zhang, et al. "Detecting and Profiling Endogenous RNA G-Quadruplexes in the Human Transcriptome." International Journal of Molecular Sciences 22, no. 15 (2021): 8012. http://dx.doi.org/10.3390/ijms22158012.

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G-quadruplexes are the non-canonical nucleic acid structures that are preferentially formed in G-rich regions. This structure has been shown to be associated with many biological functions. Regardless of the broad efforts on DNA G-quadruplexes, we still have limited knowledge on RNA G-quadruplexes, especially in a transcriptome-wide manner. Herein, by integrating the DMS-seq and the bioinformatics pipeline, we profiled and depicted the RNA G-quadruplexes in the human transcriptome. The genes that contain RNA G-quadruplexes in their specific regions are significantly related to immune pathways

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Craven, Holly M., Riccardo Bonsignore, Vasilis Lenis, et al. "Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni." PLOS Neglected Tropical Diseases 15, no. 2 (2021): e0008770. http://dx.doi.org/10.1371/journal.pntd.0008770.

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Schistosomiasis is a neglected tropical disease that currently affects over 250 million individuals worldwide. In the absence of an immunoprophylactic vaccine and the recognition that mono-chemotherapeutic control of schistosomiasis by praziquantel has limitations, new strategies for managing disease burden are urgently needed. A better understanding of schistosome biology could identify previously undocumented areas suitable for the development of novel interventions. Here, for the first time, we detail the presence of G-quadruplexes (G4) and putative quadruplex forming sequences (PQS) within

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Dang, Dung Thanh, Le Tuan Anh Nguyen, Tuom Tinh Thi Truong, Hoang Duc Nguyen, and Anh Tuân Phan. "Construction of a G-quadruplex-specific DNA endonuclease." Chemical Communications 57, no. 37 (2021): 4568–71. http://dx.doi.org/10.1039/d0cc05890d.

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A G-quadruplex-specific DNA endonuclease was constructed by fusing a RHAU G-quadruplex recognition domain with a Fok1 cleavage domain, providing a useful tool for detection of G-quadruplex structures.

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