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1

Lin, H.-J., G.-Y. Tseng, C.-L. Perng, F.-Y. Lee, F.-Y. Chang, and S.-D. Lee. "Comparison of adrenaline injection and bipolar electrocoagulation for the arrest of peptic ulcer bleeding." Gut 44, no. 5 (1999): 715–19. http://dx.doi.org/10.1136/gut.44.5.715.

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BACKGROUNDPeptic ulcers with active bleeding or a non-bleeding visible vessel require aggressive endoscopic treatment.AIMSTo determine whether endoscopic adrenaline injection alone or contact probe therapy following injection is a suitable treatment for peptic ulcer bleeding.METHODSA total of 96 patients with active bleeding or non-bleeding visible vessels received adrenaline alone, bipolar electrocoagulation alone, or combined treatment (n=32 in each group).RESULTSInitial haemostasis was not achieved in one patient in the adrenaline group, two in the gold probe group, and two in the injection
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2

Ige, Serah Funke, Bolade S. Olateju, Victor A. Oladipupo, Adedayo T. Adekola, and Oluwaseun B. Ademilua. "Role of Low Environmental Temperature in Peptic Ulcer Development." International Journal of Medical Research & Review 9, no. 3 (2021): 193–204. http://dx.doi.org/10.17511/ijmrr.2021.i03.10.

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Peptic ulcers are described as acid-induced lesions found in the stomach and duodenum caused bythe imbalance between the defending factors of the mucosa and the attacking factors such ashydrochloric acid in gastric juice, with Helicobacter Pylori (H. Pylori) and Non-Steroidal Anti-Inflammatory Drugs NSAIDs. They exhibit seasonal patterns in their occurrence, with higheroccurrence in winter and spring and a low occurrence in summer. Temperature plays a major role intheir occurrence, some of which have resulted in increased morbidity in some number of diseases,such as gastrointestinal bleeding,
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3

Jeelani Romshoo, Ghulam, Ubaid Jeelani, and Danish Qasim Shah. "ENDOSCOPIC INTERVENTIONAL MANAGEMENT USING ADRENALINE-NORMAL SALINE INJECTION FOR ACTIVELY BLEEDING PEPTIC ULCERS IN SOUTH KASHMIR, INDIA." International Journal of Advanced Research 10, no. 02 (2022): 437–42. http://dx.doi.org/10.21474/ijar01/14221.

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Aim:TodeterminetheefficacyofendoscopicNormalSalineAdrenaline(NSA)injectiontherapyinactivelybleedingpepticulcerdiseasepatientsof southernKashmir. Methods: All those patients who presented with upper GI bleed (UGB) malena/hematemesis or both underwent early upper GI endoscopy after stabilization. Those patients who had actively bleeding peptic ulcers(gastric/duodenal) were enrolled in this study. They were injected 10-15ml of 1:10000 adrenaline diluted in normal saline around the 3mm of bleeding ulcer, including ulcer base. Modified Forrest classification was used for assessment and management p
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4

Baloska, Ivana, Fana Lichoska-Josifovikj, Marjan Baloski, and Sanja Trajkova. "Bleeding duodenal ulcer in a patient with Hemophilia A: A case report." Archives of Public Health 16, no. 2 (2024): 102–6. https://doi.org/10.3889/aph.2024.6151.

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Hemophilia A is a hereditary bleeding disorder characterized by excessive musculocutaneous hemorrhage due to a congenital deficiency of factor VIII. While upper gastrointestinal bleeding in patients with hemophilia A has been reported globally, specific literature on this topic remains scarce, emphasizing the need for further research. Case presentation: A 38-year-old male presented at the Univesrity Clinic of Gastroenterhogepatology, reporting a recent episode of black stool three days prior to admission. His digital rectal examination was unremarkable, and levels of blood urea and nitrogen (
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5

Misra, S. P., and M. Dwivedi. "Endoscopic Injection Therapy for Bleeding Peptic Ulcer Using Absolute Alcohol." Tropical Doctor 28, no. 1 (1998): 28–30. http://dx.doi.org/10.1177/004947559802800108.

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The injection of sclerosants and adrenaline in a bleeding peptic ulcer is known to arrest bleeding in the majority of patients. However, there are very few studies from India on this subject. Injection therapy was carried out using absolute alcohol in 21 patients with bleeding gastric ulcer and 55 with bleeding duodenal ulcer. Injection therapy successfully controlled bleeding in all 76 patients. Bleeding recurred in two patients who were successfully managed with a second injection of absolute alcohol. Post-injection blood transfusion was required in 16 (76%) patients with gastric ulcer compa
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6

Park, K. G. M., R. J. C. Steele, and J. Masson. "Endoscopic injection of adrenaline for benign oesophageal ulcer haemorrhage." British Journal of Surgery 81, no. 9 (1994): 1317–18. http://dx.doi.org/10.1002/bjs.1800810919.

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7

BRUN, GEORG C. "The Pathogenesis of Gastric Ulcer. Typical Ulcer Pains brought on by Ingestion of Adrenaline." Acta Medica Scandinavica 110, no. 4-5 (2009): 416–43. http://dx.doi.org/10.1111/j.0954-6820.1942.tb03402.x.

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8

Kubba, AK, W. Murphy, and KR Palmer. "Endoscopic injection for bleeding peptic ulcer: A comparison of adrenaline alone with adrenaline plus human thrombin." Gastroenterology 111, no. 3 (1996): 623–28. http://dx.doi.org/10.1053/gast.1996.v111.pm8780566.

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9

Popovic, D., V. Stankovic-Popovic, I. Jovanovic, et al. "Endoscopic haemostasis of bleeding duodenal ulcer." Acta chirurgica Iugoslavica 54, no. 1 (2007): 145–50. http://dx.doi.org/10.2298/aci0701145p.

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Introduction: Acute upper gastrointestinal bleeding is the commonest emergency managed by gastroenterologists. It manifests like: haematemesis, melaena or haemochezia. Diagnostic endoscopy accurately defining the cause of hemorrhage, while therapeutic endoscopy improves prognosis in patients who present with severe bleeding. Endoscopic therapies can be classified as those based on injection, application of heat, or mechanical clips. Patients and methods: This investigation was conducted in Department of endoscopic haemostasis, Clinic for gastroenterology and hepatology, CCS, using retrospectiv
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10

Sargeant, Ian R., Louis A. Loizou, and Stephen G. Bown. "Review of Endoscopic Thermal Treatment of Peptic Ulcer Hemorrhage." Canadian Journal of Gastroenterology 4, no. 9 (1990): 653–62. http://dx.doi.org/10.1155/1990/357823.

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Peptic ulcer hemorrhage is still an important cause of emergency surgery and death. The overall mortality is around 10% from gastrointestinal bleeding, and most of the preventable deaths occur in elderly patients with continued or recurrent bleeding from peptic ulcers. An effective nonsurgical method of hemostasis has long been recognized to be desirable. However it was only when the 'visible vessel' was recognized as the important risk factor for further bleeding that studies capable of testing new modalities adequately could be performed. Careful washing of the ulcer crater is essential for
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Rutten, J.-P., F. Wolters, R. van Schelven, and C. Dejong. "Infected Liver Cyst after Adrenaline Injection for Active Duodenal Ulcer." Endoscopy 37, no. 05 (2006): 496. http://dx.doi.org/10.1055/s-2005-861277.

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12

Choudari, C. P., and K. R. Palmer. "Bleeding peptic ulcer: Injection of adrenaline or tissue adhesive (histoacryl)." Gastroenterology 108, no. 4 (1995): A72. http://dx.doi.org/10.1016/0016-5085(95)22950-7.

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13

Choudari, C. P., and K. R. Palmer. "Endoscopic injection therapy for bleeding peptic ulcer; a comparison of adrenaline alone with adrenaline plus ethanolamine oleate." Gut 35, no. 5 (1994): 608–10. http://dx.doi.org/10.1136/gut.35.5.608.

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14

Askarov, Ibragim, and Khabibullo Kodirov. "Therapy using medicinal plants to cure stomach ulcer illness and research on the characteristics of these plants." American Journal of Medical Sciences and Pharmaceutical Research 7, no. 4 (2025): 37–43. https://doi.org/10.37547/tajmspr/volume07issue04-07.

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The World Health Organization states that 10.0–15.0% of people worldwide suffer from peptic ulcers of the stomach and duodenum. The structure of gastrointestinal tract illnesses includes both benign and malignant neoplasms, peptic ulcer diseases, acute and chronic gastritis, gastroduodenitis, and functional dyspepsia. Furthermore, these plants' leaves and their The autoxidation activity of combinations with different quantities was shown to be stronger when assessed using the method of suppression of the adrenaline autoxidation process. When the AA% indications of the mixture of leaves and ste
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15

Gupta, Vineet Kumar, and Ram Chandra Soni. "A Rare Case of Gastric Outlet Obstruction due to Large Intramural Duodenal Hematoma Following Endotherapy for Bleeding Duodenal Ulcer in a Patient with End-stage Renal Disease." Journal of Digestive Endoscopy 08, no. 04 (2017): 199–201. http://dx.doi.org/10.4103/jde.jde_25_17.

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ABSTRACTWe report a very rare case and probably the first from India of gastric outlet obstruction due to a large intramural duodenal hematoma following combination endotherapy with hemoclipping and injection adrenaline 1:10,000 for actively bleeding duodenal ulcer in an elderly male patient with diabetes, hypertension, and end.stage renal disease on maintenance hemodialysis. The patient improved to approximately 6 weeks of conservative treatment with nasojejunal feeding.
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Taghavi, Seyed Alireza, Seyed Mohammad Soleimani, Seyed Mohammad Kazem Hosseini-Asl, et al. "Adrenaline Injection Plus Argon Plasma Coagulation versus Adrenaline Injection Plus Hemoclips for Treating High-Risk Bleeding Peptic Ulcers: A Prospective, Randomized Trial." Canadian Journal of Gastroenterology 23, no. 10 (2009): 699–704. http://dx.doi.org/10.1155/2009/760793.

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BACKGROUND/OBJECTIVE: Several combination endoscopic therapies are currently in use. The present study aimed to compare argon plasma coagulation (APC) + adrenaline injection (AI) with hemoclips + AI for the treatment of high-risk bleeding peptic ulcers.METHODS: In a prospective randomized trial, 172 patients with major stigmata of peptic ulcer bleeding were randomly assigned to receive APC + AI (n=89) or hemoclips + AI (n=83). In the event of rebleeding, the initial modality was used again. Patients in whom treatment or retreatment was unsuccessful underwent emergency surgery. The primary end
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17

Da Cruz, Emanuel, Indira Eugénia Eduardo, Francisco Panzo, André Domingos Faucatino, and Stephany Lukeni e Silva. "Duodenal Ulcer Complicated with Massive Upper Gastrointestinal Bleeding: Case Report." Brazilian Journal of Case Reports 5, no. 1 (2025): bjcr87. https://doi.org/10.52600/2763-583x.bjcr.2025.5.1.bjcr87.

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This case report aims to present a severe manifestation of duodenal ulcer complicated by massive upper gastrointestinal bleeding and critically low hemoglobin levels, highlighting the importance of early recognition, immediate intervention, and a multidisciplinary approach in managing patients at imminent risk of hemodynamic instability. A 64-year-old male patient with a recent history of orthopedic surgery and exploratory laparotomy was admitted to the emergency department in a coma, presenting signs of hemodynamic instability, severe anemia (hemoglobin 2.8 g/dL), metabolic acidosis, elevated
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18

Gashi, Zaim, Valon Hamza, and Astrit Hamza. "Acute hemorrhagic rectal ulcer syndrome: a rare but critical cause of lower gastrointestinal bleeding in elderly bedridden patients." Romanian Journal of Medical Practice 20, no. 2 (2025): 160–63. https://doi.org/10.37897/rjmp.2025.2.10.

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Background. Acute hemorrhagic rectal ulcer syndrome (AHRU) is a rare condition characterized by sudden, painless, severe rectal bleeding that can lead to life-threatening hemorrhage. It primarily affects elderly bedridden patients with multiple comorbidities, such as diabetes, cardiovascular disease, and renal failure. Early detection and treatment are crucial. Case report. We report the case of a 72-year-old female patient with dementia, type 2 diabetes, and a history of being bedridden for two years. She was admitted to our clinic with profuse rectal bleeding. Despite normal upper endoscopy
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19

Shaprynskyi, V. O., M. V. Hmoshynskyi, and V. R. Taheiev. "INFLUENCE OF TYPE 2 DIABETES ON THE EFFICIENCY OF ENDOSCOPIC HEMOSTASIS FOR BLEEDING FROM PEPTIC GASTRODUODENAL ULCER." Kharkiv Surgical School, no. 2-3 (June 28, 2024): 36–39. http://dx.doi.org/10.37699/2308-7005.2-3.2024.07.

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Abstract. One of the most progressive methods of treatment of gastroduodenal bleeding in peptic ulcers of the stomach and duodenum is endoscopic hemostasis (EH), which is relatively safe and highly effective. Endoscopic hemostasis in gastroduodenal ulcer bleeding is achieved in more than 90% of cases. This procedure is recommended for bleeding caused by peptic ulcers of the stomach and duodenum, as a first-line method with relatively high efficiency and a small number of complications, but it is inferior to surgical methods in terms of the number of recurrences of bleeding. The aim: analysis o
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20

Nielsen, Michael Milek, Ove B. Schaffalitzky de Muckadell, and Stig Borbjerg Laursen. "Doppler-Guided Second-Look Endoscopy in Peptic Ulcer Bleeding: A Randomised Controlled Trial." Journal of Clinical Medicine 12, no. 21 (2023): 6722. http://dx.doi.org/10.3390/jcm12216722.

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Background: Endoscopic treatment guided by Doppler endoscopic probes (DEPs) during index endoscopy may be associated with improved outcome in patients with peptic ulcer bleeding (PUB). As competencies for DEP evaluation are not always available for index endoscopy, we examined the outcome associated with DEP evaluation at second-look endoscopy. Methods: The study was designed as a non-blinded, parallel group, randomised controlled trial. Patients admitted with PUB from Forrest Ia-IIb ulcers, controlled by endoscopic therapy, were randomised (1:1 ratio) to second-look endoscopy <24 h with DE
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21

Scamporrino, A., G. Occhigrossi, G. Marenga, and G. Serafini. "Combined adrenaline injection and argon plasma coagulation in the treatment of peptic ulcer bleeding." Digestive and Liver Disease 32 (November 2000): A62. http://dx.doi.org/10.1016/s1590-8658(00)80427-2.

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22

Camellini, L., A. Merighi, N. J. Chahin, et al. "Argon plasma coagulation alone or plus adrenaline injection in peptic ulcer haemorrage: Our experience." Digestive and Liver Disease 33 (November 2001): A122. http://dx.doi.org/10.1016/s1590-8658(01)80639-3.

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23

Duhamel, C., B. Parent, C. Peillon, et al. "Endoscopic injection of adrenaline for severe peptic ulcer haemorrhage in high surgical risk patients." Intensive Care Medicine 17, no. 5 (1991): 281–84. http://dx.doi.org/10.1007/bf01713938.

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24

Asreah, Rabah H. "Endoscopic injection of adrenaline versus normal saline in bleeding peptic ulcer A prospective evaluation." Journal of the Faculty of Medicine Baghdad 51, no. 1 (2009): 27–30. http://dx.doi.org/10.32007/jfacmedbagdad.5111163.

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25

Świdnicka-Siergiejko, Agnieszka, Mariusz Rosołowski, Eugeniusz Wróblewski, Andrzej Baniukiewicz, and Andrzej Dąbrowski. "Comparison of the efficacy of two combined therapies for peptic ulcer bleeding: adrenaline injection plus haemoclipping versus adrenaline injection followed by bipolar electrocoagulation." Gastroenterology Review 6 (2014): 354–60. http://dx.doi.org/10.5114/pg.2014.47898.

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26

R Khersani, Jawad. "ENDOSCOPIC INJECTION OF DILUTED ADRENALINE FOR TREATMENT OF BLEEDING DUODENAL ULCER IN COMPARISON WITH SURGERY." Basrah Journal of Surgery 12, no. 2 (2006): 106–13. http://dx.doi.org/10.33762/bsurg.2006.55356.

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27

Narayan, Jimmy, Preetam Nath, Ayaskanta Singh, et al. "Leech Infestation Presenting as Severe Rectal Bleeding." Journal of Digestive Endoscopy 08, no. 03 (2017): 132–33. http://dx.doi.org/10.4103/jde.jde_66_16.

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ABSTRACTLeech or Hirudinea is a major parasite in rural India. Normally, the leech attacks the skin and exposed areas. An 18‑year‑old child presented with bleeding per rectum for 1 day along with giddiness. A history revealed that while the boy was working in a field, had acrawling sensation in the perianal area. After admission, the patient was resuscitated with crystalloids and a limited colonoscopy revealed a rectal ulcer with a leech head attached to its base. The hooklets were removed using foreign body removal forceps and injection Adrenaline at 1:10,000 dilutions was injected in 1 ml al
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Akmal A.B, Mohamad, Nabil Nazr, Sanjay D.S., and Yong C.W. "Life Threatening Bleeding Tuberculosis Cecal Ulcer Managed with Hemostatic Clipping – A Case Report." Asian Journal of Basic Science & Research 05, no. 04 (2023): 130–34. http://dx.doi.org/10.38177/ajbsr.2023.5408.

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Massive life threatening lower gastrointestinal bleeding in adolescent is rarely being reported. Although mostly all life threatening lower gastrointestinal bleeding end up with laparotomy and hemicolectomy, however, few literatures have reported successful management using endoscopic modalities such as achieving hemostasis by endoscopic hemoclip. We are presenting a case report of a 14-years-old Sabahan girl who presented with acute life threatening massive lower gastrointestinal bleeding. We had investigated her with a computed topography scan (CT) of abdomen and pelvis which confirmed activ
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Carter, R., and J. R. Anderson. "Randomized trial of adrenaline injection and laser photocoagulation in the control of haemorrhage from peptic ulcer." British Journal of Surgery 81, no. 6 (1994): 869–71. http://dx.doi.org/10.1002/bjs.1800810625.

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30

Laeeq, Syed Mudassir, Abbas Ali Tasneem, Farina M. Hanif, Nasir Hassan Luck, Rajesh Mandhwani, and Rajesh Wadhva. "Upper gastrointestinal bleeding in patients with end stage renal disease: causes, characteristics and factors associated with need for endoscopic therapeutic intervention." Journal of Translational Internal Medicine 5, no. 2 (2017): 106–11. http://dx.doi.org/10.1515/jtim-2017-0019.

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Abstract Background and Objectives The risk of upper gastrointestinal bleeding (UGIB) is increased among the end-stage renal disease (ESRD) patients. The aim of the current study was to describe the causes and characteristics of UGIB in ESRD patients at our center and to assess the need for endoscopic therapeutic intervention (ETI) using Rockall (RS) and Glasgow Blatchford scores (GBS). Material and Methods All patients with ESRD and UGIB with age ≥14 years were included. Frequencies and percentages were computed for categorical variables. Chi square test or Fischer’s exact test was used for s
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31

Ilnyckyj, Alexandra, and George Mathew. "Management of Acute Bleeding Upper GI Ulcers in the Era of Endoscopic and IV PPI Therapy." Canadian Journal of Gastroenterology 19, no. 3 (2005): 157–59. http://dx.doi.org/10.1155/2005/741576.

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BACKGROUND: Despite advances in therapy, the morbidity and mortality of gastrointestinal bleeding remains high. A review of current practice patterns was undertaken in St Boniface General Hospital, Winnipeg, Manitoba to assess the standard of care provided.OBJECTIVE: To determine whether upper gastrointestinal bleeding (UGIB) attributable to a single acute ulcer is treated appropriately with respect to local therapy, acid suppression and Helicobacter pylori status.METHODS: A retrospective chart review identified patients with consecutive acute UGIB attributable to a single gastric or duodenal
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32

Ramadani, Atip, Rozalinda Popova Jovanovska, Meri Trajkovska, et al. "Comparison of Argon Plasma Coagulation and Injection Therapy with Adrenalin and Polidocanol in the Management of Bleeding Angiodysplasia in Upper Gastrointestinal Tract." PRILOZI 39, no. 2-3 (2018): 63–68. http://dx.doi.org/10.2478/prilozi-2018-0043.

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AbstractIntroduction:The term angiodysplasia (AD) refers to acquired malformation of the blood vessels (communications between veins and capillaries), frequently found within the gastrointestinal mucosa and submucosa. AD of stomach and duodenum are cause of upper gastrointestinal bleeding in 4%-7% of patients. The means of treatment are usually endoscopic, including argon plasma coagulation (APC), electrocoagulation, mechanical hemostasis by clippsing, laser photo-coagulation and injection therapy.Aim:To compare the success rate, and adverse events (ulcer lesions, perforations) of APC and inje
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33

Wong, S. K. H. "Prediction of therapeutic failure after adrenaline injection plus heater probe treatment in patients with bleeding peptic ulcer." Gut 50, no. 3 (2002): 322–25. http://dx.doi.org/10.1136/gut.50.3.322.

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34

Motko, N., I. Fomenko, and O. Vozna. "The role of gas mediators of nitrogen (II) oxide and hydrogen sulfide in the development of pathochemical changes in the mucous membrane of rats at water-immobilization and adrenaline-induced stress modeling." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 22, no. 97 (2020): 88–94. http://dx.doi.org/10.32718/nvlvet9715.

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Acute and prolonged psycho-emotional overstrain, i.e. stress, are the most frequent factors of ulcer formation in the digestive system. Therefore, the study of molecular mechanisms of stress impact is one of the most promising directions of modern experimental gastroenterology. However, the features of its molecular-biochemical action on the metabolic processes in the digestive system remain insufficiently studied. In this regard, we performed a comparative analysis of changes in indicators of systems of gas mediators of nitrogen (II) oxide and hydrogen sulfide synthesis at water-immobilizatio
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35

Kortan, Paul. "Injection Therapy for Nonvariceal Gastrointestinal Bleeding." Canadian Journal of Gastroenterology 4, no. 9 (1990): 650–52. http://dx.doi.org/10.1155/1990/120392.

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Gastrointestinal hemorrhage is a common and serious problem - its average mortality of 10% has changed little over the past 40 years. In 80% of patients the bleeding stops spontaneously. In patients with continuous or recurrent bleeding (20%), mortality and morbidity are high, and emergency surgery is often required, which has a higher mortality than the same operation performed electively. Successful therapeutic endoscopic intervention in this high risk group is necessary to improve outcome. For injection treatment of nonvariceal bleeding lesions, the author has been using the Soehendra metho
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WADA, Daisuke. "Experimental study on cause of recurrent ulcer after selective proximal vagotomy with special reference to the effect of adrenaline." Japanese Journal of Gastroenterological Surgery 20, no. 10 (1987): 2278–85. http://dx.doi.org/10.5833/jjgs.20.2278.

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Tekant, Y., P. Goh, D. J. Alexander, J. R. Isaac, C. K. Kum, and S. S. Ngoi. "Combination therapy using adrenaline and heater probe to reduce rebleeding in patients with peptic ulcer haemorrhage: A prospective randomized trial." British Journal of Surgery 82, no. 2 (1995): 223–26. http://dx.doi.org/10.1002/bjs.1800820231.

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Polat, Esra, Nevzat Aykut Bayrak, Günsel Kutluk, and Hasret Ayyıldız Civan. "Pediatric upper gastrointestinal bleeding in children: etiology and treatment approaches." Journal of Emergency Practice and Trauma 6, no. 2 (2020): 59–62. http://dx.doi.org/10.34172/jept.2020.10.

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Objective: Upper gastrointestinal bleeding (UGB) is one of the most important and serious cause of emergency admission in childhood. The aim of the study was to evaluate the etiological factors and the treatment approaches in patients with UGB. Methods: In this retrospective study, children with UGB admitted to emergency clinics of Istanbul Health Sciences University Kanuni Sultan Suleyman Research and Training Hospital, Istanbul Bakirkoy Sadi Konuk Research and Training Hospital and Diyarbakir Children’s Hospital were evaluated between January 2014 and August 2017. Results: Of the 198 childre
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EL HAWARY, AMR, and Emad Moustafa. "Evaluation of the Efficacy of Adrenaline Injection Versus Argon Plasma Coagulation Either Alone or Combined in Controlling Acute Bleeding Peptic Ulcer." Afro-Egyptian Journal of Infectious and Endemic Diseases 8, no. 3 (2018): 129–39. http://dx.doi.org/10.21608/aeji.2018.13309.

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Lv, Xiao-Jin, Jing-Jing Zhang, Ting Wang, Ru-Ping Duan, and Wei-Ren Lin. "Endoscopically guided titanium clip therapy and adrenaline injection for treatment of patients with peptic ulcer bleeding: Clinical efficacy and impact on serum inflammatory cytokines." World Chinese Journal of Digestology 26, no. 2 (2018): 99–104. http://dx.doi.org/10.11569/wcjd.v26.i2.99.

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Palmela, Carolina, Catarina Gouveia, Catarina Fidalgo, and Alexandre Oliveira Ferreira. "Rare case of a giant duodenal ulcer penetrating the pancreas during antiangiogenic treatment." BMJ Case Reports 12, no. 5 (2019): e228612. http://dx.doi.org/10.1136/bcr-2018-228612.

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We report a case of a patient with renal cell carcinoma on pazopanib, who presented with severe upper gastrointestinal bleeding. Endoscopy showed a giant bulbar ulcer with a visible vessel of 4 mm. Due to unavailability of surgical rescue backup, large calibre vessel treatment was delayed. Endoscopy was repeated after 48 hours and showed a reduction in the vessel diameter. Endoscopic adrenalin injection and electrocoagulation were performed. However, the vessel increased in size and became pulsatile. The patient was operated, confirming a giant bulbar ulcer penetrating the pancreas with active
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Chung, S. S. C., J. Y. W. Lau, J. J. Y. Sung, et al. "Randomised comparison between adrenaline injection alone and adrenaline injection plus heat probe treatment for actively bleeding ulcers." BMJ 314, no. 7090 (1997): 1307. http://dx.doi.org/10.1136/bmj.314.7090.1307.

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Loizou, L. A., and S. G. Bown. "Endoscopic treatment for bleeding peptic ulcers: randomised comparison of adrenaline injection and adrenaline injection + Nd:YAG laser photocoagulation." Gut 32, no. 10 (1991): 1100–1103. http://dx.doi.org/10.1136/gut.32.10.1100.

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Leung, J. W. C., and S. C. S. Chung. "Endoscopic injection of adrenalin in bleeding peptic ulcers." Gastrointestinal Endoscopy 33, no. 2 (1987): 73–75. http://dx.doi.org/10.1016/s0016-5107(87)71512-0.

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PFEIFFER, NAOMI. "Should Adrenalin Injection Replace Laser Therapy in Treating Bleeding Peptic Ulcer?" Journal of Clinical Laser Medicine & Surgery 13, no. 4 (1995): 295–96. http://dx.doi.org/10.1089/clm.1995.13.295.

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Chung, S. C. S., J. W. C. Leung, R. J. C. Steele, T. J. Crofts, and A. K. C. Li. "Endoscopic injection of adrenaline for actively bleeding ulcers: a randomised trial." BMJ 296, no. 6637 (1988): 1631–33. http://dx.doi.org/10.1136/bmj.296.6637.1631.

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Hussaini, S. H., M. Hull, S. C. S. Chung, J. Y. W. Lau, and A. K. C. Li. "Adding heat probe treatment to adrenaline injection for spurting haemorrhage of peptic ulcers." BMJ 315, no. 7114 (1997): 1016. http://dx.doi.org/10.1136/bmj.315.7114.1016.

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Sollano, Jose D., V. N. Ang, and J. A. Moreno. "Endoscopic hemostasis of bleeding peptic ulcers: 1:10000 adrenalin injection vs. 1:10000 adrenalin +1% aethoxysclerol injection vs. heater probe." Gastroenterologia Japonica 26, S3 (1991): 83–85. http://dx.doi.org/10.1007/bf02779271.

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Repici, A., A. Ferrari, C. De Angelis, et al. "Adrenaline plus cyanoacrylate injection for treatment of bleeding peptic ulcers after failure of conventional endoscopic haemostasis." Digestive and Liver Disease 34, no. 5 (2002): 349–55. http://dx.doi.org/10.1016/s1590-8658(02)80129-3.

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Mnati, Saeed F. "Effect of Infection With Scabies on The Adrenaline Hormone Of Patients With Chronic Diseases In Basra City/ Southern Iraq." BASRA JOURNAL OF SCIENCE 39, no. 1 (2021): 168–78. http://dx.doi.org/10.29072/basjs.2021111.

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Abstract:
Scabies, a parasitic skin infestation by the burrowing “itch” mite Sarcoptes scabiei, causes significant health problems for children and adults worldwide. Crusted scabies is a particularly severe form of scabies in which mites multiply into the millions, causing extensive skin crusting. The symptoms and signs of scabies suggest host immunity to the scabies mite. The defense against stress is executed by the hypothalamic-pituitary-adrenal axis and the sympathetic-adrenal medullary system. Adrenal gland is a major effector organ of stress system. During stress, adrenal gland rapidly responds wi
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