Academic literature on the topic 'Adult mouse kidney'
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Journal articles on the topic "Adult mouse kidney":
Little, Melissa H. "Diving Deep into the Adult Mouse Kidney." Developmental Cell 51, no. 3 (November 2019): 293–94. http://dx.doi.org/10.1016/j.devcel.2019.10.015.
Webb, Carol F., Michelle L. Ratliff, Rebecca Powell, Celeste R. Wirsig-Wiechmann, Olga Lakiza, and Tomoko Obara. "A developmentally plastic adult mouse kidney cell line spontaneously generates multiple adult kidney structures." Biochemical and Biophysical Research Communications 463, no. 4 (August 2015): 1334–40. http://dx.doi.org/10.1016/j.bbrc.2015.06.130.
KIM, YOUNG-HEE, JAE-HO EARM, TONGHUI MA, ALAN S. VERKMAN, MARK A. KNEPPER, KIRSTEN M. MADSEN, and JIN KIM. "Aquaporin-4 Expression in Adult and Developing Mouse and Rat Kidney." Journal of the American Society of Nephrology 12, no. 9 (September 2001): 1795–804. http://dx.doi.org/10.1681/asn.v1291795.
Robert, Barry, Xuemei Zhao, and Dale R. Abrahamson. "Coexpression of neuropilin-1, Flk1, and VEGF164 in developing and mature mouse kidney glomeruli." American Journal of Physiology-Renal Physiology 279, no. 2 (August 1, 2000): F275—F282. http://dx.doi.org/10.1152/ajprenal.2000.279.2.f275.
Robert, B., P. L. St John, D. P. Hyink, and D. R. Abrahamson. "Evidence that embryonic kidney cells expressing flk-1 are intrinsic, vasculogenic angioblasts." American Journal of Physiology-Renal Physiology 271, no. 3 (September 1, 1996): F744—F753. http://dx.doi.org/10.1152/ajprenal.1996.271.3.f744.
Kim, Myoung-Jin, Daeun Moon, Sumi Jung, Jehee Lee, and Jinu Kim. "Cisplatin nephrotoxicity is induced via poly(ADP-ribose) polymerase activation in adult zebrafish and mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 318, no. 5 (May 1, 2020): R843—R854. http://dx.doi.org/10.1152/ajpregu.00130.2019.
Hirsch, Sara, Tarek El-Achkar, Lynn Robbins, Jeannine Basta, Monique Heitmeier, Ryuichi Nishinakamura, and Michael Rauchman. "A mouse model of Townes-Brocks syndrome expressing a truncated mutant Sall1 protein is protected from acute kidney injury." American Journal of Physiology-Renal Physiology 309, no. 10 (November 15, 2015): F852—F863. http://dx.doi.org/10.1152/ajprenal.00222.2015.
Watanabe, Hirofumi, Robert L. Paxton, Matthew R. Tolerico, Vidya K. Nagalakshmi, Shinji Tanaka, Mark D. Okusa, Shin Goto, et al. "Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells." American Journal of Physiology-Renal Physiology 319, no. 4 (October 1, 2020): F603—F611. http://dx.doi.org/10.1152/ajprenal.00348.2020.
Abuazza, Ghazala, Amy Becker, Scott S. Williams, Sumana Chakravarty, Hoang-Trang Truong, Fangming Lin, and Michel Baum. "Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins." American Journal of Physiology-Renal Physiology 291, no. 6 (December 2006): F1132—F1141. http://dx.doi.org/10.1152/ajprenal.00063.2006.
Durbeej, Madeleine, Michael D. Henry, Maria Ferletta, Kevin P. Campbell, and Peter Ekblom. "Distribution of Dystroglycan in Normal Adult Mouse Tissues." Journal of Histochemistry & Cytochemistry 46, no. 4 (April 1998): 449–57. http://dx.doi.org/10.1177/002215549804600404.
Dissertations / Theses on the topic "Adult mouse kidney":
Myszczyszyn, Adam. "Studying normal and cancer stem cells in the kidney using 3D organoids and genetic mouse models." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/23127.
Adult mouse organoids are promising models for kidney research. However, their characterization has not been pushed forward to a satisfying level. Here, I have generated and characterized a long-term 3D mouse organoid (tubuloid) model, which recapitulates renewal and repair, and the architecture and functionality of the adult tubular epithelia. In the future, the model will allow detailed investigations of trajectories of self-renewing cells towards both the partial recreation and malignant transformation of the kidney. Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive kidney cancer. Inactivation of the Von Hippel-Lindau (VHL) tumor suppressor gene is the major driver of ccRCC. Earlier, we identified the upregulation of Wnt and Notch signaling in CXCR4+MET+CD44+ cancer stem cells (CSCs) from primary human ccRCCs. Blocking Wnt and Notch in patient-derived xenografts, organoids and non-adherent spheres using small-molecule inhibitors impaired self-renewal of CSCs and tumor growth. To mimic CSC-governed human ccRCC in genetic mouse models, I started from the generation of two double mouse mutants; β-catenin-GOF; Notch-GOF and Vhl-LOF; β-catenin-GOF. Surprizingly, I observed neither tumors or tumor precursor lesions nor higher cell proliferation rates in the mutant kidneys. Further analyses revealed that the mutant mice displayed features of chronic kidney disease (CKD). Thus, β-catenin-GOF; Notch-GOF and Vhl-LOF; β-catenin-GOF mouse mutants did not develop kidney tumors under the given experimental conditions.
Po-TsangLee and 李柏蒼. "Progenitor Cells Derived from Adult Mouse Kidney Mesenchyme Accelerate Renal Regeneration after Ischemic Injury." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/12617859242552339537.
國立成功大學
臨床醫學研究所
98
In Taiwan, the incidence of end-stage renal disease ranked first and the prevalence ranked second in the world. Patients with end-stage renal disease need hemodialysis, peritoneal dialysis or kidney transplant to maintain their life. For the shortage of available organ, most of the patients are under regular dialysis. To accelerate renal repair or even make a functioning kidney is the emergent issue to be solved and interesting topic for research. Following the discovery of tissue-specific progenitor cells in other organs and their ability to improve regeneration after injury, progenitor cell-based therapy is a new strategy in the treatment of acute kidney injury and has potentially more value than single-agent drug therapy due to the highly versatile response of cells to their environment. These cells may not only secrete cytokines within the injured kidney, but also participate in tubular cell proliferation or angiogenesis to facilitate renal regeneration. In rodents, increasing evidence suggests that the therapeutic potential of mesenchymal stem cells derived from bone marrow could be beneficial in the kidney injury. Thereby, we hypothesize that kidney progenitor cells may accelerate renal regeneration after injury. We first observed the regenerative process of acute tubular necrosis in rodents. In the normal kidney, only interstitial cells but not tubular cells expressed vimentin. Following acute renal failure, vimentin-positive renal interstitial cells proliferated and surrounded the damaged renal tubules as early as 12 hours after injury. Within the regenerating tubules, vimentin staining was found intensely two days after injury, and disappeared after full recovery of tubular epithelial cells. By known interstitial cell markers, only few vimentin-positive renal interstitial cells were characterized as endothelial cells or fibroblasts one day after acute renal failure. Most of the other proliferating cells were not specified and we hypothesize that kidney progenitor cells could reside in these areas. Using bromodeoxyuridine (BrdU) as a marker of proliferating cells, we monitor the distribution of the interstitial cells by immunohistochemistry during acute renal failure. Following one injection of BrdU, eighty five percent of BrdU labeling cells located in the interstitium 12 hours after acute renal failure and the count decreased to 25% at the 4th day. Interestingly, BrdU labeling cells redistributed to the regenerating tubules at the 1st and 4th day. Seventy-five percentage of BrdU labeling cells located in the tubules at the 4th day. As assessed by ELISA, the uptake of BrdU in the kidney peaked at the 1st day, decreased to constant level after 3 days, and maintained till 7 days following one injection of BrdU before acute renal failure. These results indicate that interstitial cells might be engaged in the process of tubular regeneration after acute renal failure. We test the hypothesis that renal progenitor cells isolated from adult mouse kidney accelerate renal regeneration via participation in the repair process. A unique population of cells exhibiting characteristics consistent with renal progenitor cells, mouse kidney progenitor cells (MKPC), was isolated from Myh9 targeted mutant mice. Features of these cells include: (1) spindle-shaped morphology, (2) self-renewal of more than 100 passages without evidence of senescence, (3) expression of Oct-4, Pax-2, Wnt-4, WT-1, vimentin, alpha-smooth muscle actin, CD29 and S100A4 but no SSEA-1, c-kit, or other markers of more differentiated cells. MKPC exhibit plasticity as demonstrated by the ability to differentiate into endothelial cells and osteoblasts in vitro and endothelial cells and tubular epithelial cells in vivo. The origin of the isolated MKPC was from the interstitium of medulla and papilla. Importantly, intra-renal injection of MKPC in mice with ischemic injury rescued renal damage, as manifested by decreases in peak serum urea nitrogen, the infarct zone and the necrotic injury. Seven days after the injury, some MKPC formed vessels with red blood cells inside and some incorporated into renal tubules. In addition, MKPC treatment reduces the mortality in mice after ischemic injury. Our results indicate that MKPC represent a multipotent adult progenitor cell population, which may contribute to the renal repair and prolong survival after ischemic injury. The PhD study not only raised a novel method to treat acute renal failure but also open a new window to elucidate the relationship between kidney progenitor cells and tubular regeneration. Based on these, we will be able to unveil the mechanism of how tissue-specific progenitor cells involve in the process of tissue regeneration.
Book chapters on the topic "Adult mouse kidney":
Thornhill, Barbara A., and Robert L. Chevalier. "Variable Partial Unilateral Ureteral Obstruction and Its Release in the Neonatal and Adult Mouse." In Kidney Development, 381–92. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-851-1_33.
Chow, Theresa, Jennifer Whiteley, and Ian M. Rogers. "Decellularizing and Recellularizing Adult Mouse Kidneys." In Methods in Molecular Biology, 169–84. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9021-4_15.