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Journal articles on the topic 'Advanced biomanufacturing'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Ye, Kaiming, David L. Kaplan, Gang Bao, et al. "Advanced Cell and Tissue Biomanufacturing." ACS Biomaterials Science & Engineering 4, no. 7 (2018): 2292–307. http://dx.doi.org/10.1021/acsbiomaterials.8b00650.

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Penloglou, Giannis, and Alexandros Kiparissides. "Advanced Modeling of Biomanufacturing Processes." Processes 12, no. 2 (2024): 387. http://dx.doi.org/10.3390/pr12020387.

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The multi-layered and complex nature of cellular regulation enhances the need for advanced computational methodologies that can serve as scaffolds for organizing experimental data to facilitate the inference of meaningful relationships [...]

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3

Sugita, Naohiko, and Mamoru Mitsuishi. "Special Issue on Biomanufacturing." International Journal of Automation Technology 8, no. 1 (2014): 73. http://dx.doi.org/10.20965/ijat.2014.p0073.

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The development of medical devices and systems is essential for improving quality of life and reducing global healthcare costs. Machine tools are increasingly used in the medical, automotive, airplane, and electronics fields thanks to advances in manufacturing technology. The processing of artificial implants and biomaterials, for example, and parts of medical devices such as endoscopes are manufactured with multiaxis machine tools. This demand is expected to increase as society ages. Equipment used in diagnostics and surgery has also developed rapidly. Despite the use of advanced diagnostics

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Jardini, A. L., M. A. Larosa, M. F. Macedo, et al. "Improvement in Cranioplasty: Advanced Prosthesis Biomanufacturing." Procedia CIRP 49 (2016): 203–8. http://dx.doi.org/10.1016/j.procir.2015.11.017.

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Aijaz, Ayesha, Matthew Li, David Smith, et al. "Biomanufacturing for clinically advanced cell therapies." Nature Biomedical Engineering 2, no. 6 (2018): 362–76. http://dx.doi.org/10.1038/s41551-018-0246-6.

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6

Gargalo, Carina L., Isuru Udugama, Katrin Pontius, et al. "Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes." Journal of Industrial Microbiology & Biotechnology 47, no. 11 (2020): 947–64. http://dx.doi.org/10.1007/s10295-020-02308-1.

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AbstractThe biomanufacturing industry has now the opportunity to upgrade its production processes to be in harmony with the latest industrial revolution. Technology creates capabilities that enable smart manufacturing while still complying with unfolding regulations. However, many biomanufacturing companies, especially in the biopharma sector, still have a long way to go to fully benefit from smart manufacturing as they first need to transition their current operations to an information-driven future. One of the most significant obstacles towards the implementation of smart biomanufacturing is

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Jiang, Wei, Yanjun Li, and Huadong Peng. "Engineering Biology of Yeast for Advanced Biomanufacturing." Bioengineering 10, no. 1 (2022): 10. http://dx.doi.org/10.3390/bioengineering10010010.

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8

Allenby, Mark C., and Maria A. Woodruff. "Image analyses for engineering advanced tissue biomanufacturing processes." Biomaterials 284 (May 2022): 121514. http://dx.doi.org/10.1016/j.biomaterials.2022.121514.

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Carter, Sarah-Sophia D., Pedro F. Costa, Cedryck Vaquette, Saso Ivanovski, Dietmar W. Hutmacher, and Jos Malda. "Additive Biomanufacturing: An Advanced Approach for Periodontal Tissue Regeneration." Annals of Biomedical Engineering 45, no. 1 (2016): 12–22. http://dx.doi.org/10.1007/s10439-016-1687-2.

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Papathanasiou, Maria M., Baris Burnak, Justin Katz, Nilay Shah, and Efstratios N. Pistikopoulos. "Assisting continuous biomanufacturing through advanced control in downstream purification." Computers & Chemical Engineering 125 (June 2019): 232–48. http://dx.doi.org/10.1016/j.compchemeng.2019.03.013.

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Wang, Xueting, Ali Mohsin, Yifei Sun, Chao Li, Yingping Zhuang, and Guan Wang. "From Spatial–Temporal Multiscale Modeling to Application: Bridging the Valley of Death in Industrial Biotechnology." Bioengineering 10, no. 6 (2023): 744. http://dx.doi.org/10.3390/bioengineering10060744.

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The Valley of Death confronts industrial biotechnology with a significant challenge to the commercialization of products. Fortunately, with the integration of computation, automation and artificial intelligence (AI) technology, the industrial biotechnology accelerates to cross the Valley of Death. The Fourth Industrial Revolution (Industry 4.0) has spurred advanced development of intelligent biomanufacturing, which has evolved the industrial structures in line with the worldwide trend. To achieve this, intelligent biomanufacturing can be structured into three main parts that comprise digitaliz

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12

Huang, Jianghong, Jianyi Xiong, Daping Wang, et al. "3D Bioprinting of Hydrogels for Cartilage Tissue Engineering." Gels 7, no. 3 (2021): 144. http://dx.doi.org/10.3390/gels7030144.

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Three-dimensional (3D) bioprinting is an emerging technology based on 3D digital imaging technology and multi-level continuous printing. The precise positioning of biological materials, seed cells, and biological factors, known as “additive biomanufacturing”, can provide personalized therapy strategies in regenerative medicine. Over the last two decades, 3D bioprinting hydrogels have significantly advanced the field of cartilage and bone tissue engineering. This article reviews the development of 3D bioprinting and its application in cartilage tissue engineering, followed by a discussion of th

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Park, Seo-Young, Cheol-Hwan Park, Dong-Hyuk Choi, Jong Kwang Hong, and Dong-Yup Lee. "Bioprocess digital twins of mammalian cell culture for advanced biomanufacturing." Current Opinion in Chemical Engineering 33 (September 2021): 100702. http://dx.doi.org/10.1016/j.coche.2021.100702.

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14

Oancea, A., Q. Shao, S. Lin, et al. "CAR-T CELLS MANUFACTURING AT ADVANCED BIOMANUFACTURING FACILITY JACKSONVILLE FLORIDA." Cytotherapy 26, no. 6 (2024): e26. http://dx.doi.org/10.1016/j.jcyt.2024.04.053.

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15

Henn, Alicia D., Mark Wolff, Kunal Mitra, et al. "Smart biomanufacturing for health equity in regenerative medicine therapies." Regenerative Medicine Reports 2, no. 1 (2025): 31–35. https://doi.org/10.4103/regenmed.regenmed-d-24-00021.

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Limited scalability and restricted affordability impede the equitable deployment of curative models of care despite advances achieved with regenerative medicine therapeutics. Mitigating the risk of widening health disparities mandates actions that would improve the availability and accessibility of new classes of biotherapeutics. Namely, the use of Smart Manufacturing empowered by artificial intelligence to increase therapeutic production capacity while reducing cost is an emerging strategy central to the future of the regenerative care economy. Establishing an efficient and effective biomanuf

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16

Bailey, Kolene E., Michael L. Floren, Tyler J. D’Ovidio, Steven R. Lammers, Kurt R. Stenmark, and Chelsea M. Magin. "Tissue-informed engineering strategies for modeling human pulmonary diseases." American Journal of Physiology-Lung Cellular and Molecular Physiology 316, no. 2 (2019): L303—L320. http://dx.doi.org/10.1152/ajplung.00353.2018.

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Chronic pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension (PH), and chronic obstructive pulmonary disease (COPD), account for staggering morbidity and mortality worldwide but have limited clinical management options available. Although great progress has been made to elucidate the cellular and molecular pathways underlying these diseases, there remains a significant disparity between basic research endeavors and clinical outcomes. This discrepancy is due in part to the failure of many current disease models to recapitulate the dynamic changes that occur

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17

Peng, Jiao, and Chen Biqiang. "Advanced Bioprocess Development and Biomanufacturing Technologies and High Throughput Miniature Bioreactors." Chinese Journal of Engineering Science 18, no. 4 (2016): 44. http://dx.doi.org/10.15302/j-sscae-2016.04.007.

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18

Hu, Shunyang, Bangxu Wang, Liang Pei, et al. "Advances and Challenges in Biomanufacturing of Glycosylation of Natural Products." Fermentation 10, no. 7 (2024): 349. http://dx.doi.org/10.3390/fermentation10070349.

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Glycosylation is one of the most common and important modifications in natural products (NPs), which can alter the biological activities and properties of NPs, effectively increase structural diversity, and improve pharmacological activities. The biosynthesis of glycosylation in natural products involves multiple complex biological processes, which are coordinated by many enzymes. UDP-glycosyltransferases (UGTs) play a crucial role in glycosylation modification, and have attracted long-term and widespread research attention. UGTs can catalyze the O-, C-, S-, and N-glycosylation of different su

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Assal, Rami El, Pu Chen, and Utkan Demirci. "Highlights from the latest articles in advanced biomanufacturing at micro- and nano-scale." Nanomedicine 10, no. 3 (2015): 347–50. http://dx.doi.org/10.2217/nnm.14.210.

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20

Zhao, Beichen, Xueliang Li, Wanqiang Sun, et al. "BioDT: An Integrated Digital-Twin-Based Framework for Intelligent Biomanufacturing." Processes 11, no. 4 (2023): 1213. http://dx.doi.org/10.3390/pr11041213.

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The field of industrial biotechnology has shown an increasing interest in adopting digital twins for improving process productivity and management efficiency. Despite its potential benefits, digital-twin-based biomanufacturing has not been fully implemented. As a preliminary undertaking, we developed an open-source digital twin framework for cell culture. The core models of the digital twin were coded in C++ and compiled as a reusable Python library. A web-based, cloud-native HMI application that links the physical and virtual systems was developed. A microbioreactor digital twin system was im

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21

Palmer, Xavier-Lewis, Lucas Potter, and Saltuk Karahan. "Exploration on APTs in Biocybersecurity and Cyberbiosecurity." International Conference on Cyber Warfare and Security 17, no. 1 (2022): 532–35. http://dx.doi.org/10.34190/iccws.17.1.67.

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Novel and complex digital threats that are increasingly interwoven with means and products of biology that can affect society. Much work in Biocybersecurity/Cyberbiosecurity (BCS/CBS) discuss vulnerabilities, but few deeply address malicious actor varieties as attacks at this intersection are new. The path to those attacks remains mostly theoretical, presenting considerable difficulty to accomplish in practical scenarios. In terms of advanced persistent threats (APTs) this of course needs to change as biomanufacturing facilities are at risk, considering Covid-19 and other potential pandemics.

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22

Duchi, Serena, Stephanie Doyle, Timon Eekel, et al. "Protocols for Culturing and Imaging a Human Ex Vivo Osteochondral Model for Cartilage Biomanufacturing Applications." Materials 12, no. 4 (2019): 640. http://dx.doi.org/10.3390/ma12040640.

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Cartilage defects and diseases remain major clinical issues in orthopaedics. Biomanufacturing is now a tangible option for the delivery of bioscaffolds capable of regenerating the deficient cartilage tissue. However, several limitations of in vitro and experimental animal models pose serious challenges to the translation of preclinical findings into clinical practice. Ex vivo models are of great value for translating in vitro tissue engineered approaches into clinically relevant conditions. Our aim is to obtain a viable human osteochondral (OC) model to test hydrogel-based materials for cartil

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23

Wei, Qingshan. "(Invited) Smartphone Diagnostics Meets CRISPR." ECS Meeting Abstracts MA2023-02, no. 63 (2023): 2970. http://dx.doi.org/10.1149/ma2023-02632970mtgabs.

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Smartphone-based optical imaging and sensing devices are among the next-generation biosensors that have shown great potential to transform the field of point-of-care (POC) diagnostics. With the rapid improvement of hardware (e.g., lens, image sensor, and CPU), smartphone has become a transformative microscopy and sensing platform that can support various detection or biomedical measurement applications, especially for resource-limited settings. On the other side, smartphone diagnostics can maximize its potential for early disease detection by coupling with specific molecular assays, such as nu

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24

Dwarshuis, Nate J., Kirsten Parratt, Adriana Santiago-Miranda, and Krishnendu Roy. "Cells as advanced therapeutics: State-of-the-art, challenges, and opportunities in large scale biomanufacturing of high-quality cells for adoptive immunotherapies." Advanced Drug Delivery Reviews 114 (May 2017): 222–39. http://dx.doi.org/10.1016/j.addr.2017.06.005.

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25

Kim, Nayeong, Jiho Lee, Jemin Jeon, Johannes Elbert, and Xiao Su. "Electrochemical Recovery of Biomolecules in Redox-Mediated Electrodialysis Platform." ECS Meeting Abstracts MA2024-01, no. 55 (2024): 2911. http://dx.doi.org/10.1149/ma2024-01552911mtgabs.

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In the chemical and biochemical manufacturing industry, the recovery and purification of organic species are amongst the most energy-demanding steps, due to the complexity of product streams, involving unreacted reactants, byproducts, inorganic salts along with the final products.1, 2 Membrane-integrated electrochemical methods have garnered interest as promising candidates for selective recovery of organic molecules, such as whey protein from cheese whey waste.3 Nonetheless, they still encounter a bottleneck in discriminating among charged species, primarily due to the lack of intrinsic ion s

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26

Kim, Nayeong, Aderiyike Aguda, Jiho Lee, Jemin Jeon, Johannes Elbert, and Xiao Su. "Advancements in Redox-Mediated Electrodialysis for Valorization of Biomolecules." ECS Meeting Abstracts MA2024-02, no. 25 (2024): 2056. https://doi.org/10.1149/ma2024-02252056mtgabs.

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In the chemical and biochemical manufacturing industry, separation processes are amongst the most energy-demanding processes, accounting for 50% of total operating costs.1, 2 Redox-mediated electrodialysis (redox-ED) has attracted attention as a process-intensified method for resource recovery, particularly selective recovery of organic molecules such as proteins and organic acids.2, 3 By replacing water-splitting reactions with reversible redox reactions, pH-sensitive biomolecules can be electrochemically recovered with reduced overall energy consumption. We demonstrated the valorization of p

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Su, Xiao, Nayeong Kim, and Johannes Elbert. "Advances in Redox-Electrodialysis for Energy-Efficient Desalination." ECS Meeting Abstracts MA2024-02, no. 49 (2024): 3495. https://doi.org/10.1149/ma2024-02493495mtgabs.

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Electrochemical separations have rapidly grown in recent years due to advances in functional materials as well as architecture design. By bridging the technologies between redox-based energy storage and desalination, redox-mediated electrodialysis (redox-ED) has been shown to achieve continuous desalination from brackish water to seawater, with reduced energy consumption. Here, we provide an overview the advances in redox-electrodialysis, in terms of materials design as well as electrochemical engineering. First, by replacing costly and sensitive ion-exchange membranes (IEMs) with robust nanof

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28

Antony Jose, Subin, Jordan Jackson, Jayden Foster, Terrence Silva, Ethan Markham, and Pradeep L. Menezes. "In-Space Manufacturing: Technologies, Challenges, and Future Horizons." Journal of Manufacturing and Materials Processing 9, no. 3 (2025): 84. https://doi.org/10.3390/jmmp9030084.

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In-space manufacturing represents a transformative frontier in space exploration and industrial production, offering the potential to revolutionize how goods are produced and resources are utilized beyond Earth. This paper explores the multifaceted aspects of in-space manufacturing, including its evolution, technologies, challenges, and future prospects, while also addressing ethical and legal dimensions critical to its development. Beginning with an overview of its significance and historical context, this paper underscores key concepts such as resource optimization and the reduction of launc

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Matt Blois. "US funding advances biomanufacturing." C&EN Global Enterprise 102, no. 27 (2024): 10. http://dx.doi.org/10.1021/cen-10227-buscon2.

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30

Ye, Kaiming, and Athanassios Sambanis. "Advanced Biomanufacturing: A Radical Manufacturing Paradigm Shift from Conventional, Centralized, Off-the-Shelf Production to On-Demand, Decentralized, Plug-and-Play Production of Cell- and Tissue-Based Products." ACS Biomaterials Science & Engineering 3, no. 8 (2017): 1460–61. http://dx.doi.org/10.1021/acsbiomaterials.7b00535.

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31

Klontzas, Michail E., Spyros I. Vernardis, Aristea Batsali, Fotios Papadogiannis, Nicki Panoskaltsis, and Athanasios Mantalaris. "Machine Learning and Metabolomics Predict Mesenchymal Stem Cell Osteogenic Differentiation in 2D and 3D Cultures." Journal of Functional Biomaterials 15, no. 12 (2024): 367. https://doi.org/10.3390/jfb15120367.

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Stem cells have been widely used to produce artificial bone grafts. Nonetheless, the variability in the degree of stem cell differentiation is an inherent drawback of artificial graft development and requires robust evaluation tools that can certify the quality of stem cell-based products and avoid source-tissue-related and patient-specific variability in outcomes. Omics analyses have been utilised for the evaluation of stem cell attributes in all stages of stem cell biomanufacturing. Herein, metabolomics in combination with machine learning was utilised for the benchmarking of osteogenic diff

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Kruschitz, Andreas, Linda Peinsipp, Martin Pfeiffer, and Bernd Nidetzky. "Continuous process technology for glucoside production from sucrose using a whole cell-derived solid catalyst of sucrose phosphorylase." Applied Microbiology and Biotechnology 105, no. 13 (2021): 5383–94. http://dx.doi.org/10.1007/s00253-021-11411-x.

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Abstract Advanced biotransformation processes typically involve the upstream processing part performed continuously and interlinked tightly with the product isolation. Key in their development is a catalyst that is highly active, operationally robust, conveniently produced, and recyclable. A promising strategy to obtain such catalyst is to encapsulate enzymes as permeabilized whole cells in porous polymer materials. Here, we show immobilization of the sucrose phosphorylase from Bifidobacterium adolescentis (P134Q-variant) by encapsulating the corresponding E. coli cells into polyacrylamide. Ap

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33

Lavoie, R., Alice di Fazio, R. Blackburn, Michael Goshe, Ruben Carbonell, and Stefano Menegatti. "Targeted Capture of Chinese Hamster Ovary Host Cell Proteins: Peptide Ligand Discovery." International Journal of Molecular Sciences 20, no. 7 (2019): 1729. http://dx.doi.org/10.3390/ijms20071729.

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The growing integration of quality-by-design (QbD) concepts in biomanufacturing calls for a detailed and quantitative knowledge of the profile of impurities and their impact on the product safety and efficacy. Particularly valuable is the determination of the residual level of host cell proteins (HCPs) secreted, together with the product of interest, by the recombinant cells utilized for production. Though often referred to as a single impurity, HCPs comprise a variety of species with diverse abundance, size, function, and composition. The clearance of these impurities is a complex issue due t

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34

David, Peter O. "Abstract A001: Navigating the future of therapeutic development: innovations in safety and efficacy through advanced research methodologies and nanotechnology." Molecular Cancer Therapeutics 23, no. 12_Supplement (2024): A001. https://doi.org/10.1158/1538-8514.cancerchem24-a001.

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Abstract In recent years, the field of therapeutic development has experienced a significant paradigm shift driven by strategic scientific innovations that prioritize safety and efficacy in therapeutic agents. This paper explores the intersection of advanced research methodologies, novel material sciences, and biotechnological advancements that are revolutionizing the approach to drug formulation and delivery systems. The integration of precision medicine principles alongside cutting-edge technologies allows for the design of therapeutics that are not only effective in targeting specific disea

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35

Wohlgemuth, Roland. "Biomanufacturing as Key Technology for a Sustainable Bioeconomy." CHIMIA 79, no. 5 (2025): 352–58. https://doi.org/10.2533/chimia.2025.352.

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Scientific and technological advances have created new biomanufacturing opportunities by overcoming manufacturing challenges and problems in various industrial sectors step by step and thereby lead to sustainable value creation. Bottom-up biomanufacturing approaches can provide value to customers in a competitive environment and when located in a geographically well-connected ecosystem bring additional benefits, such as derisking of supply chains, reduction of complexity, or strategic autonomy. The strategic importance of biomanufacturing can also be seen by different top-down initiatives and

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36

Sheikhbahei, Erfan, and Aysu AKILLI ARI. "Harnessing the Power of Emerging Digital Technologies for improved Sustainability and Productivity in Biomedical Engineering and Neuroscience." Scientific Hypotheses 1 (April 18, 2024): 47–52. http://dx.doi.org/10.69530/v8tgp793.

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This article discusses the potential of using digital technologies like blockchain, AI, IoT and big data analytics to improve resource efficiency, supply chain management, decision making and reduce fraud. It highlights how blockchain can create a transparent and tamper-proof system for tracking forest products from harvest to sale, reducing fraud and improving sustainability. The implementation of blockchain is argued to lead to substantial improvements in supply chain management through increased transparency and traceability. Moreover, AI, blockchain, IoT and advanced analytics are said to

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37

Kruschitz, Andreas, та Bernd Nidetzky. "Biocatalytic Production of 2‑α‑D‑Glucosyl-glycerol for Functional Ingredient Use: Integrated Process Design and Techno-Economic Assessment". ACS Sustainable Chem. Eng. 10, № 3 (2022): 1246–55. https://doi.org/10.1021/acssuschemeng.1c07210.

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<strong>Abstract</strong> Advanced biomanufacturing builds on production processes that are both profitable and sustainable. Integrated design of process unit operations, geared to output efficiency and waste minimization and guided by a rigorous techno-economic assessment, is essential for development aligned to these central aims. Here, we demonstrate such a development for the biocatalytic production of the biological extremolyte 2-O-<em>α</em>-D-glucosyl-glycerol (2-GG) for functional ingredient application. The process was aligned in scale over all steps (&sim;180 g product; &sim;2.

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38

Lee, Eun Yeol. "Recent Advances on Biocatalysis and Metabolic Engineering for Biomanufacturing." Catalysts 9, no. 9 (2019): 707. http://dx.doi.org/10.3390/catal9090707.

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The use of biocatalysts, including enzymes and metabolically engineered cells, has attracted a great deal of attention in chemical and bio-industry, because biocatalytic reactions can be conducted under environmentally-benign conditions and in more sustainable ways [...]

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Goudar, Chetan, Kevin McFarland, and Michael Betenbaugh. "Editorial overview: Latest Advances and Current Challenges in Biomanufacturing." Current Opinion in Chemical Engineering 22 (December 2018): i—iii. http://dx.doi.org/10.1016/j.coche.2018.12.002.

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Liu, Juanjuan, Guangpeng Xu, Likun Liang, and Dongdong Meng. "Sugar phosphatases as biocatalysts for biomanufacturing: Recent advances and applications." Biotechnology Advances 82 (September 2025): 108596. https://doi.org/10.1016/j.biotechadv.2025.108596.

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Kitsuka, Takahiro, Fuga Takahashi, James Reinhardt, et al. "Advances in Cardiac Tissue Engineering." Bioengineering 9, no. 11 (2022): 696. http://dx.doi.org/10.3390/bioengineering9110696.

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Tissue engineering has paved the way for the development of artificial human cardiac muscle patches (hCMPs) and cardiac tissue analogs, especially for treating Myocardial infarction (MI), often by increasing its regenerative abilities. Low engraftment rates, insufficient clinical application scalability, and the creation of a functional vascular system remain obstacles to hCMP implementation in clinical settings. This paper will address some of these challenges, present a broad variety of heart cell types and sources that can be applied to hCMP biomanufacturing, and describe some new innovativ

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42

F, Lisan, Ullah K, Siraj S, Akhtar A, Lai W, and Wang X. "Advances in Baculovirus Expression System and its Important Applications." International Journal of Zoology and Animal Biology 7, no. 6 (2024): 1–14. https://doi.org/10.23880/izab-16000634.

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The Baculovirus Expression Vector System (BEVS) inserts foreign genes into insect cells using insect-specific baculoviruses. This strong technique allows high-level recombinant protein expression and correct folding in eukaryotic conditions. For nearly 30 years, it has been a cornerstone of biological research and innovation. This system background and numerous applications are covered in this overview. Baculovirus form, structure, replication mode, and host range are discussed. The ideas and procedures of they are explained, emphasizing its gene delivery efficacy. We study they use in exogeno

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43

Le, Huong, Nandita Vishwanathan, Nitya M. Jacob, Mugdha Gadgil, and Wei-Shou Hu. "Cell line development for biomanufacturing processes: recent advances and an outlook." Biotechnology Letters 37, no. 8 (2015): 1553–64. http://dx.doi.org/10.1007/s10529-015-1843-z.

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44

Bautista-Vanegas, Freddy Ednildon, Jose Luis Diaz-Guerrero, Ingrid Neysa Cabezas-Soliz, et al. "Bioprocess Engineering: Advances in Cell Culture Systems, Reactor Design, Scale-up Strategies, and Intensification Processes for the Production of Biological and Bioactive Compounds." eVitroKhem 4 (June 20, 2025): 149. https://doi.org/10.56294/evk2025149.

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Bioprocess engineering is undergoing an unprecedented transformation, driven by the growing demand for complex and bioactive biological products across diverse industries, from pharmaceuticals to food and energy. Recent advances have redefined the efficiency, scalability, and sustainability of biomanufacturing. Key elements of this evolution include the widespread adoption of single-use systems, the integration of automation and artificial intelligence (AI) for precise control and predictive optimization, and the fundamental shift toward continuous bioprocessing. These innovations not only red

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45

Delalov, Yunus Kh, Shamil I. Akbaev, and Edgar S. Kafarov. "MODERN ADVANCES IN 3D BIOPRODUCTION OF KIDNEYS: ECONOMIC ANALYSIS AND PROSPECTS FOR INTEGRATION INTO HEALTHCARE." EKONOMIKA I UPRAVLENIE: PROBLEMY, RESHENIYA 12/12, no. 153 (2024): 43–53. https://doi.org/10.36871/ek.up.p.r.2024.12.12.005.

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Recent advances in 3D biomanufacturing of kidneys open up new opportunities for medicine, in particular for the treatment of chronic renal failure and solving the problem of donor organ shortage. This article reviews key technologies used in 3D bioprinting of kidneys, including biomaterials, cell constructs, and additive manufacturing methods. It analyzes the economic aspects of the development and implementation of this technology, such as the cost of creating bioprostheses, potential savings due to reduced costs of traditional treatments and transplantation, and the possible impact on the he

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Sun, Jae Nam, Binil Starly and Wei. "Design by chip: Computer-aided tissue engineering." Biochemist 29, no. 1 (2007): 20–23. http://dx.doi.org/10.1042/bio02901020.

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Computer-aided tissue engineering (CATE) is an evolving, multi-disciplinary field that utilizes the tools of medical image processing, computer-aided design (CAD), computational analysis, multiscale modelling and biomanufacturing for the purposes of tissue engineering. The merging of computation and automation with tissue engineering could have the potential for profound advances in developing tissue replacements and also in better understanding of physiology and pathology at a cellular, tissue, and organ level.

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Kyriakopoulos, Sarantos, Kok Siong Ang, Meiyappan Lakshmanan, et al. "Kinetic Modeling of Mammalian Cell Culture Bioprocessing: The Quest to Advance Biomanufacturing." Biotechnology Journal 13, no. 3 (2017): 1700229. http://dx.doi.org/10.1002/biot.201700229.

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Chen, Kai, Seulhee Kim, Siying Yang, et al. "Advanced biomanufacturing and evaluation of adeno-associated virus." Journal of Biological Engineering 18, no. 1 (2024). http://dx.doi.org/10.1186/s13036-024-00409-4.

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AbstractRecombinant adeno-associated virus (rAAV) has been developed as a safe and effective gene delivery vehicle to treat rare genetic diseases. This study aimed to establish a novel biomanufacturing process to achieve high production and purification of various AAV serotypes (AAV2, 5, DJ, DJ8). First, a robust suspensive production process was developed and optimized using Gibco Viral Production Cell 2.0 in 30–60 mL shaker flask cultures by evaluating host cells, cell density at the time of transfection and plasmid amount, adapted to 60–100 mL spinner flask production, and scaled up to 1.2–

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Reger, Lucas Nik, Martin Saballus, Jens Matuszczyk, et al. "Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells." Frontiers in Bioengineering and Biotechnology 11 (February 16, 2023). http://dx.doi.org/10.3389/fbioe.2023.1106292.

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Monoclonal antibodies (mAb) have gained enormous therapeutic application during the last decade as highly efficient and flexible tools for the treatment of various diseases. Despite this success, there remain opportunities to drive down the manufacturing costs of antibody-based therapies through cost efficiency measures. To reduce production costs, novel process intensification methods based on state-of-the-art fed-batch and perfusion have been implemented during the last few years. Building on process intensification, we demonstrate the feasibility and benefits of a novel, innovative hybrid p

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Wang, Liang, Chongyang Zhang, Jianhua Zhang, et al. "Epsilon-poly-L-lysine: Recent Advances in Biomanufacturing and Applications." Frontiers in Bioengineering and Biotechnology 9 (September 28, 2021). http://dx.doi.org/10.3389/fbioe.2021.748976.

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ε-poly-L-lysine (ε-PL) is a naturally occurring poly(amino acid) of varying polymerization degree, which possesses excellent antimicrobial activity and has been widely used in food and pharmaceutical industries. To provide new perspectives from recent advances, this review compares several conventional and advanced strategies for the discovery of wild strains and development of high-producing strains, including isolation and culture-based traditional methods as well as genome mining and directed evolution. We also summarize process engineering approaches for improving production, including opt

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