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Journal articles on the topic 'Advanced dissolution'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Denninger, Alexander, Tim Becker, Ulrich Westedt, and Karl G. Wagner. "Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models." Pharmaceutics 15, no. 7 (2023): 1978. http://dx.doi.org/10.3390/pharmaceutics15071978.

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Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passive transport, prodrug activation, and first-pass metabolism. The objective of the present study was to assess the predictability of human pharmacokinetics by using biphasic dissolution results obtained with the previously established BiPHa+ assay and PBPK tools. For six commercial drug products, formulated by different enabling technologies, the res

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2

Orian, Laura. "Editorial: Special Issue on “Advanced Strategies for Catalyst Design”." Catalysts 11, no. 1 (2020): 38. http://dx.doi.org/10.3390/catal11010038.

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3

Fan, Xuliang, Yangfan Zhang, Jing Li, et al. "A general dissolution–recrystallization strategy to achieve sulfur-encapsulated carbon for an advanced lithium–sulfur battery." Journal of Materials Chemistry A 6, no. 25 (2018): 11664–69. http://dx.doi.org/10.1039/c8ta02180e.

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A novel dissolution–recrystallization strategy is, for the first time, proposed to fabricate a series of carbon@S cathodes via dissolution–recrystallization of granular sulfur into uniform sulfur layer encapsulated carbon in selective solution.

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4

Cappelli, Chiara, Daniel Lamarca-Irisarri, Jordi Camas, F. Javier Huertas, and Alexander E. S. Van Driessche. "In situ observation of biotite (001) surface dissolution at pH 1 and 9.5 by advanced optical microscopy." Beilstein Journal of Nanotechnology 6 (March 5, 2015): 665–73. http://dx.doi.org/10.3762/bjnano.6.67.

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Laser confocal differential interference contrast microscopy (LCM-DIM) allows for the study of the reactivity of surface minerals with slow dissolution rates (e.g., phyllosilicates). With this technique, it is possible to carry out in situ inspection of the reacting surface in a broad range of pH, ionic strength and temperature providing useful information to help unravel the dissolution mechanisms of phyllosilicates. In this work, LCM-DIM was used to study the mechanisms controlling the biotite (001) surface dissolution at pH 1 (11 and 25 °C) and pH 9.5 (50 °C). Step edges are the preferentia

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Kryeziu, Arjeta, Václav Slovák, and Alžběta Parchaňská. "Liquefaction of Cellulose for Production of Advanced Porous Carbon Materials." Polymers 14, no. 8 (2022): 1621. http://dx.doi.org/10.3390/polym14081621.

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Cellulose is a renewable resource for the production of advanced carbonaceous materials for various applications. In addition to direct carbonization, attention has recently been paid to the preparation of porous carbons from liquid cellulose-based precursors. Possible pathways of cellulose conversion to a liquid state suitable for the preparation of porous carbons are summarized in this review. Hydrothermal liquefaction leading to liquid mixtures of low-molecular-weight organics is described in detail together with less common decomposition techniques (microwave or ultrasound assisted liquefa

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6

Lyu, Xiaocong, and Denis Voskov. "Advanced modeling of enhanced CO2 dissolution trapping in saline aquifers." International Journal of Greenhouse Gas Control 127 (July 2023): 103907. http://dx.doi.org/10.1016/j.ijggc.2023.103907.

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7

Justen, Anna, Alina Faye Weltersbach, Gerhard Schaldach, and Markus Thommes. "Design and Characterization of a Melt Electrostatic Precipitator for Advanced Drug Formulations." Processes 12, no. 1 (2024): 100. http://dx.doi.org/10.3390/pr12010100.

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Electrostatic precipitators (ESP) are especially known for the efficient separation of micron and submicron particles from aerosols. Wet electrostatic precipitators are particularly suitable for highly resistive materials. Using these, particles can be directly transferred into a liquid for further processing or safer handling, which is advantageous for either hazardous or valuable materials. In this work, a wet ESP, which enables the separation of highly resistive particles into a heated liquid, was designed and investigated. To do this, spray-dried drug particles were embedded in a molten su

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Sekine, Nobuhide, and Wataru Nakao. "Advanced Self-Healing Ceramics with Controlled Degradation and Repair by Chemical Reaction." Materials 16, no. 19 (2023): 6368. http://dx.doi.org/10.3390/ma16196368.

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Controlling the chemical reaction rate concerning degradation and repair is found to be important to design advanced self-healing ceramics. The recovery and degradation behaviors of strength and stiffness were investigated by exposing aqueous solutions of different pH and calcium ion concentrations to the introduced crack on typical self-healing ceramics dispersed with alumina cement as a self-healing agent. The chemical reaction of cement undergoes the following three stages: dissolution of components such as calcium ions, formation of a gel, and formation of final products. Experimental and

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9

Cherevko, Serhiy. "(Invited) Electrocatalysts Dissolution in PEM Water Electrolyzers." ECS Meeting Abstracts MA2025-01, no. 38 (2025): 1824. https://doi.org/10.1149/ma2025-01381824mtgabs.

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Modern proton exchange membrane water electrolyzers (PEMWE) utilize Ir- and Pt-based electrocatalysts to accelerate oxygen and hydrogen reactions. Even these noble metals are not completely immune and dissolve, which makes their application at very low metal loadings challenging. Numerous alternative electrocatalysts that have been actively explored over recent years demonstrate much lower dissolution stability. Material science and operational stabilization approaches can increase the lifetime of both state-of-the-art and advanced electrocatalysts. An advanced understanding of dissolution rea

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Thangadurai, Venkataraman. "(Invited) Garnet Solid Electrolytes for Advanced All-Solid-State Li Metal Batteries." ECS Meeting Abstracts MA2022-02, no. 47 (2022): 1759. http://dx.doi.org/10.1149/ma2022-02471759mtgabs.

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These days, Li metal anode-based battery has been arisen as one of the key energy storage technologies due to its high theoretical energy density compared to conventional lithium and sodium ion-based batteries. The present Li-S batteries suffer due to Li dendrite formation and capacity decay due to polysulfide dissolution effect, because of organic electrolytes used in the current research. Solid state (ceramic) electrolytes are promising to prevent Li dendrite growth and polysulfide dissolution. Among different ceramic electrolytes garnet-type structure solid inorganic electrolytes are very p

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11

Abou-Taleb, Heba A., Wesam W. Mustafa, Tarek Saad Makram, Lamiaa N. Abdelaty, Hesham Salem, and Hamdy Abdelkader. "Vardenafil Oral Dispersible Films (ODFs) with Advanced Dissolution, Palatability, and Bioavailability." Pharmaceutics 14, no. 3 (2022): 517. http://dx.doi.org/10.3390/pharmaceutics14030517.

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Oral, quick response, and on demand, also known as a spontaneous oral treatment for erectile dysfunction, is highly needed by both patients and physicians. Vardenafil is selective (fewer side effects) and more effective in difficult-to-treat conditions than sildenafil. This study aims at fostering the dual objectives of using biomolecules such as artificial sweetening agents to solubilize and mask the bitterness of vardenafil loaded on biodegradable polymeric materials (PVA, MC, SA, and PVP K30) to fabricate oral, fast-dissolving films (vardenafil ODFs) in the mouth without the need for water

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12

SAITO, Takayuki, Takeo KAJISHIMA, and Katsumi TSUCHIYA. "Deep Ocean CO2 Sequestration via GLAD (Gas-Lift Advanced Dissolution) System." Journal of Environment and Engineering 6, no. 2 (2011): 412–15. http://dx.doi.org/10.1299/jee.6.412.

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13

Komsta, Łukasz, and Katarzyna Wicha-Komsta. "Quantitative evaluation of dissolution profiles: From simple approaches to advanced chemometrics." Arhiv za farmaciju 74, no. 2 (2024): 105–17. http://dx.doi.org/10.5937/arhfarm74-49757.

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Many forms of drugs are designed to undergo dissolution upon oral administration. The kinetics and efficiency of this process are critical parameters to be controlled. The methods of its evaluation are described in official guidelines issued by the Food and Drug Administration (FDA), European Medicines Agency (EMA) and World Health Organization (WHO). Many approaches of comparison have been proposed, because these guidelines are not limited to a particular mathematical method. This review summarizes the current state of this topic, covering both model-dependent and model-independent methods, a

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14

Yan, Min, Yang Zhang, Yu Li, et al. "Manganese dioxide nanosheet functionalized sulfur@PEDOT core–shell nanospheres for advanced lithium–sulfur batteries." Journal of Materials Chemistry A 4, no. 24 (2016): 9403–12. http://dx.doi.org/10.1039/c6ta03211g.

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MnO<sub>2</sub> nanosheet functionalized S@PEDOT core–shell nanospheres demonstrate highly enhanced electrochemical performance for Li–S batteries, benefitting from effectively trapping polysulfides, minimizing polysulfide dissolution, and improving cathode conductivity and wettability.

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15

Reddy, Dr P. Jayachandra, S. Manoj, M. Sirisha, P. Sravani, P. Sindhu, and D. Yuva Sree. "Evaluation and standardization of different marketed products of Ashwagandha tablets." Future Journal of Pharmaceuticals and Health Sciences 5, no. 3 (2025): 29–35. https://doi.org/10.26452/fjphs.v5i3.773.

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Herbal tablets are compressed solid dosage forms of powdered plants, herbal extracts, or their constituents. Because each of these dosage forms contains a specific amount of medication that is taken as a single unit, they are frequently referred to as solid unit dose forms. Evaluation and standardization of Ashwagandha herbal tablet available in market. To Evaluate Ashwagandha tablets, which include hardness, friability, weight variation, content uniformity, disintegrationtime, dissolution test and standardization of marketed products. The sample tablets A, B, C& D are within IP limits in

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16

Jia, Jingfu, Kerong Zhang, Xue Zhou, Dan Zhou, and Fahuan Ge. "Precise Dissolution Control and Bioavailability Evaluation for Insoluble Drug Berberine via a Polymeric Particle Prepared Using Supercritical CO2." Polymers 10, no. 11 (2018): 1198. http://dx.doi.org/10.3390/polym10111198.

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It is still controversial whether poor aqueous solubility is the most primary reason for the low oral bioavailability of insoluble drugs. Therefore, in this study, berberine-loaded solid polymeric particles (BPs) of varied dissolution profiles with β-cyclodextrin (β-CD) as carrier were fabricated using solution-enhanced dispersion by supercritical fluids (SEDS), and the relationship between dissolution and berberine (BBR) bioavailability was evaluated. Dissolution property was controlled via particle morphology manipulation, which was achieved by adjusting several key operating parameters duri

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17

Bajmalu Rostami, Rahman, Pedro de Souza Ciacco, Mauricio Claudio Viali Muñoz, Luis Fellipe Simoes та Calixto Isaac Garcia. "Influence of High-Temperature Deformation on the Dissolution of δ-Ferrite in Stainless Steels". Metals 14, № 7 (2024): 783. http://dx.doi.org/10.3390/met14070783.

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The dissolution behavior of δ-ferrite in two commercial stainless steels, 15-5PH and M-154, was studied. In this work, a new approach combining hot deformation and additional post-treatment was investigated and compared with conventional annealing heat treatments for the dissolution of δ-ferrite. The results showed the acceleration in the dissolution of δ-ferrite using the new methodology. Samples from each steel were subjected to conventional annealing heat treatments at 1000 °C and 1150 °C, with soaking times of 1, 2, and 3 h. A second set of samples was subjected to hot compression experime

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18

Jacobsen, Ann-Christin, Anna Krupa, Martin Brandl, and Annette Bauer-Brandl. "High-Throughput Dissolution/Permeation Screening—A 96-Well Two-Compartment Microplate Approach." Pharmaceutics 11, no. 5 (2019): 227. http://dx.doi.org/10.3390/pharmaceutics11050227.

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Early formulation screening can alleviate development of advanced oral drug formulations, such as amorphous solid dispersions (ASDs). Traditionally, dissolution is used to predict ASD performance. Here, a high-throughput approach is described that simultaneously screens drug dissolution and permeation employing a two-compartment 96-well plate. Freeze-drying from hydro-alcoholic solutions was used to prepare amorphous formulations. The screening approach was tested on amorphous and crystalline tadalafil formulations with and without Soluplus®. The workflow consisted of: (1) dispersion of the fo

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19

Ahmed, Mohd Muqtader, P. Ravi, K. E. Pravallika та Sarwat Hazeeqa. "Studies on Risperidone Loaded β-Cyclodextrin Nanosponges for Managing Altered Mental Status and Delirium in Cancer Patients". Journal of Cancer Research Updates 13 (25 грудня 2024): 66–74. https://doi.org/10.30683/1929-2279.2024.13.09.

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This study explores the prospective of risperidone-loaded β-cyclodextrin nanosponges as a therapeutic strategy for managing altered mental status (AMS) and delirium in cancer patients. Almost 87% of patients with advanced cancer experience AMS or delirium, significantly impacting prognosis and quality of life. The present study aims to enhance the solubility, bioavailability, and therapeutic effectiveness of second-generation antipsychotic medication risperidone (RSP), with poor aqueous solubility, it was encapsulated in β-cyclodextrin nanosponges. The nanosponges prepared by fusion technique

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20

Adithya Karthik, Bhattiprolu, Kollipara Sivacharan, Boddu Rajkumar, Rachapally Arvind, and Ahmed Tausif. "Model Independent and Dependent Methods for Dissolution Profiles Comparison: Can we take the Road Less Travelled?" International Journal of Pharmaceutical Sciences and Developmental Research 10, no. 1 (2024): 022–09. http://dx.doi.org/10.17352/ijpsdr.000053.

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Dissolution testing plays an important role in pharmaceutical development due to its ability to provide critical insight into in vivo performance. Dissolution testing during routine pharmaceutical development can ensure batch-to-batch consistency and helps to ensure that the commercial batches are of representative quality to that of studied in the pivotal clinical studies. For comparing the dissolution profiles, there are multitude of approaches suggested by various regulatory agencies that consist of model independent and dependent approaches. The present review aims to summarize the current

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21

Gopaiah, K. Venkata, Ramya Teja Medarametla, J. N. Suresh Kumar, et al. "Advanced Granulation and Formulation Strategies for Histamine H2 Receptor Antagonists in Peptic Ulcer Disease Management." Journal of Neonatal Surgery 14, no. 10S (2025): 1000–1013. https://doi.org/10.63682/jns.v14i10s.6812.

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Present work seeks to formulate floating tablets of famotidine Hydrochloride employing HPMC K4M, HPMC K15M and HPMC K100M polymers. The bulk density of the floating drug delivery systems is lower than the gastric fluid density and therefore has the potential to be suspended in the gastric cavity for long durations of time although the rate of gastric emptying is unaffected. Famotidine is classified as a histamine H2 receptor antagonist and it is on the World Health Organization's Model List of Essential Medicines used for the treatment of peptic ulcer disease (PUD) and gastro oesophageal reflu

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22

Tao, Yuting, Shaohua Jin, Tongbin Wang, et al. "Preparation, Thermal Behavior, and Conformational Stability of HMX/Cyclopentanone Cocrystallization." Crystals 14, no. 8 (2024): 711. http://dx.doi.org/10.3390/cryst14080711.

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The cocrystallization of 1,3,5,7-tetranitro-1,3,5,7-tetrazolidine (HMX) with cyclopentanone was achieved via a controlled cooling method, followed by comprehensive characterization that confirmed the α-configuration of HMX within the cocrystal. The enthalpy of dissolution of HMX in cyclopentanone was assessed across a range of temperatures using a C-80 Calvert microcalorimeter, revealing an endothermic dissolution process. Subsequently, the molar enthalpy of dissolution was determined, and kinetic equations describing the dissolution rate were derived for temperatures of 303.15, 308.15, 313.15

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Manrique-Torres, Yady Juliana, Danielle J. Lee, Faiza Islam, et al. "Crushed Tablets: Does the Administration of Food Vehicles and Thickened Fluids to Aid Medication Swallowing Alter Drug Release?" Journal of Pharmacy & Pharmaceutical Sciences 17, no. 2 (2014): 207. http://dx.doi.org/10.18433/j39w3v.

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Purpose. To evaluate the influence of co-administered vehicles on in vitro dissolution in simulated gastric fluid of crushed immediate release tablets as an indicator for potential drug bioavailability compromise. Methods. Release and dissolution of crushed amlodipine, atenolol, carbamazepine and warfarin tablets were tested with six foods and drinks that are frequently used in the clinical setting as mixers for crushed medications (water, orange juice, honey, yoghurt, strawberry jam and water thickened with Easythick powder) in comparison to whole tablets. Five commercial thickening agents (E

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TAKAHASHI, Takuma, and Wuled LENGGORO. "Synthesis and Dissolution of Particles for Advanced Mass Transport in Plant Bodies." Hosokawa Powder Technology Foundation ANNUAL REPORT 30 (May 25, 2023): 125–27. http://dx.doi.org/10.14356/hptf.21506.

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25

Dhruvi Mehta, Dhruvi Mehta, Sahil Jethi Sahil Jethi, Kush Thakkar Kush Thakkar, and Aatman Pathak Aatman Pathak. "Revolutionizing drug formulation: Advanced approaches for enhancing solubility." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 1829–42. https://doi.org/10.35629/4494-100318291842.

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This article is done deliberately to easily understand the concepts of solubility enhancement techniques with their diagrammatic representation. Nowadays, newer potent drugs are facing solubility issues, which is a challenging aspect in the pharmaceutical industry. Many efficacious drugs are not able to reach the market due to their low solubilisation factor, and this creates a negative impact in the pharmaceutical field. Here, we have focused on the major techniques for solubility enhancement such as Particle size reduction, Lipophilicity of the drug,Cosolvency, Sonocrystallization, Nanonizat

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Gao, Ying, Tibi Sorop, Niels Brussee, et al. "Advanced Digital-SCAL Measurements of Gas Trapped in Sandstone." Petrophysics – The SPWLA Journal of Formation Evaluation and Reservoir Description 64, no. 3 (2023): 368–83. http://dx.doi.org/10.30632/pjv64n3-2023a4.

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Trapped gas saturation (Sgr) plays an important role in subsurface engineering, such as carbon capture and storage, H2 storage efficiency as well as the production of natural gas. Unfortunately, Sgr is notoriously difficult to measure in the laboratory or field. The conventional method of measurement—low-rate unsteady-state coreflooding—is often impacted by gas dissolution effects, resulting in large uncertainties of the measured Sgr. Moreover, it is not understood why this effect occurs, even for brines carefully pre-equilibrated with gas. To address this question, we used high-resolution X-r

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Nguyen, Viet Nhan Hoa, Si Jeong Song, and Man Seung Lee. "Dissolution of Palladium Metal in Solvent Leaching System with the Presence of Oxidizing Agent." Metals 11, no. 4 (2021): 575. http://dx.doi.org/10.3390/met11040575.

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Platinum group metals (PGMs) are important for the manufacture of advanced materials in the field of catalysts and electronic devices. Since the chemical properties of PGMs are very similar to each other, hydrometallurgical processes should be employed to recover PGMs with high purity from either ores or secondary resources. In hydrometallurgical processes for PGMs, the first step is the dissolution of PGMs. For this purpose, inorganic acid solutions with oxidizing agents are generally employed. In this work, nonaqueous solvent leaching systems with a relatively cheap price were employed to in

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Denninger, Alexander, Ulrich Westedt, Jörg Rosenberg, and Karl G. Wagner. "A Rational Design of a Biphasic Dissolution Setup—Modelling of Biorelevant Kinetics for a Ritonavir Hot-Melt Extruded Amorphous Solid Dispersion." Pharmaceutics 12, no. 3 (2020): 237. http://dx.doi.org/10.3390/pharmaceutics12030237.

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Biphasic dissolution systems achieved good predictability for the in vivo performance of several formulations of poorly water-soluble drugs by characterizing dissolution, precipitation, re-dissolution, and absorption. To achieve a high degree of predictive performance, acceptor media, aqueous phase composition, and the apparatus type have to be carefully selected. Hence, a combination of 1-decanol and an optimized buffer system are proposed as a new, one-vessel biphasic dissolution method (BiPHa+). The BiPHa+ was developed to combine the advantages of the well-described biorelevance of the Uni

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Yang, Zheng, Qingxiang Ma, Lei Han, and Kai Tao. "Design of Mo-doped cobalt sulfide hollow nanocages from zeolitic imidazolate frameworks as advanced electrodes for supercapacitors." Inorganic Chemistry Frontiers 6, no. 8 (2019): 2178–84. http://dx.doi.org/10.1039/c9qi00663j.

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A Mo-doped CoS HNC with enhanced electrochemical performance was designed by using ZIF-67 as a self-sacrificial template through a dissolution–regrowth process in the presence of NaMoO<sub>4</sub> with an additional sulfurization process.

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MINAGAWA, KEIJI, MOHAMED R. BERBER, INAS H. HAFEZ, TAKESHI MORI, and MASAMI TANAKA. "ADVANCED NANOHYBRID FORMULATION OF THE SPARINGLY SOLUBLE DRUG SULINDAC FOR CONTROLLED RELEASE STUDIES." International Journal of Modern Physics: Conference Series 06 (January 2012): 610–15. http://dx.doi.org/10.1142/s2010194512003856.

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We offered an advanced nanohybrid formulation system of Sulindac (SUL) based on layered double hydroxide (LDH) nanoparticles. The formulated materials were characterized by X-rays, Infrared and SEM techniques to confirm the nanohybrid structure. The drug incorporation ratio was determined to be 45%. The drug solubility was improved after the LDH nanohybrid formation. The anion-exchange mechanism of LDH supported the dissolution process for the intercalated SUL.

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Bílik, Tomáš, Jakub Vysloužil, Martina Naiserová, et al. "Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of Pharmacopoeial and Dynamic Biorelevant Dissolution Study." Pharmaceutics 14, no. 1 (2022): 127. http://dx.doi.org/10.3390/pharmaceutics14010127.

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Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in various pharmaceutical fields of interest. We aimed to explore its application in hypromellose matrix systems (HPMC content 10–30%) compared to the traditionally used microcrystalline cellulose (MCC) PH 102. The properties of powder mixtures and directly compressed tablets containing individual fillers NEU or MCC, or their blend with ratios of 1.

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Djuris, Jelena, Sandra Cvijic, and Ljiljana Djekic. "Model-Informed Drug Development: In Silico Assessment of Drug Bioperformance following Oral and Percutaneous Administration." Pharmaceuticals 17, no. 2 (2024): 177. http://dx.doi.org/10.3390/ph17020177.

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The pharmaceutical industry has faced significant changes in recent years, primarily influenced by regulatory standards, market competition, and the need to accelerate drug development. Model-informed drug development (MIDD) leverages quantitative computational models to facilitate decision-making processes. This approach sheds light on the complex interplay between the influence of a drug’s performance and the resulting clinical outcomes. This comprehensive review aims to explain the mechanisms that control the dissolution and/or release of drugs and their subsequent permeation through biolog

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Simonian, Michael H. "Full Spectrum Quantitation: An Advanced UV/Visible Spectroscopic Method for Multicomponent Dissolution Testing." Dissolution Technologies 2, no. 2 (1995): 3–6. http://dx.doi.org/10.14227/dt020295p3.

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Cappelli, Chiara, Alexander E. S. Van Driessche, Jordi Cama, and F. Javier Huertas. "In Situ Observation of Biotite Dissolution at pH 1 Using Advanced Optical Microscopy." Crystal Growth & Design 13, no. 7 (2013): 2880–86. http://dx.doi.org/10.1021/cg400285a.

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Gordon, N., D. Starosvetsky, and Y. Ein-Eli. "Negative potential dissolution (NPD)-advanced and rapid texturing method of as-cut silicon." Electrochimica Acta 50, no. 27 (2005): 5313–21. http://dx.doi.org/10.1016/j.electacta.2005.03.008.

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Bindhani, Sabitri, and Snehamayee Mohapatra. "RECENT APPROACHES OF SOLID DISPERSION: A NEW CONCEPT TOWARD ORAL BIOAVAILABILITY SABITRI BINDHANI* , SNEHAMAYEE MOHAPATRA." Asian Journal of Pharmaceutical and Clinical Research 11, no. 2 (2018): 72. http://dx.doi.org/10.22159/ajpcr.2018.v11i2.23161.

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Solid dispersion (SD) has been a major advanced technology in overcoming dissolution and bioavailability problem of poorly soluble compounds. Formulation of SD in water-soluble carrier has becoming more researched over the past four decades for solubility and relative bioavailability enhancement. By reduction of the size of the drug particle to the minimum level which will enhance drug wettability and ultimately bioavailability will be definitely improved. This review article elaborates recent advanced technology and characterization of SDs and also discusses the problems and their solution fo

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Qelliny, Milad Reda, Wesam W. Mustafa, Adel Al Fatease, Ali H. Alamri, Raid Alany, and Hamdy Abdelkader. "Biofunctional Excipients: Their Emerging Role in Overcoming the Inherent Poor Biopharmaceutical Characteristics of Drugs." Pharmaceutics 17, no. 5 (2025): 598. https://doi.org/10.3390/pharmaceutics17050598.

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Background/Objectives: With advancements in biomaterial sciences, biofunctional excipients have emerged to focus on solving issues with the drugs’ inherent biopharmaceutical characteristics such as poor solubility, permeability, in vivo dissolution, and effective targeting. These advanced excipients significantly impact drug solubility, dissolution rates, absorption rates, permeation rates, penetration ability, targeting ability, and pharmacokinetic profiles. Methods: A literature review of recently published articles was prepared. Data were collected using scientific search engines. This revi

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Bourassa, Kyle, Grace Brennan, Avshalom Caspi, and Terrie Moffitt. "RELATIONSHIP DISSOLUTION AND BIOLOGICAL AGING IN MID LIFE." Innovation in Aging 7, Supplement_1 (2023): 95. http://dx.doi.org/10.1093/geroni/igad104.0309.

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Abstract Several decades of empirical research has shown that people who experience relationship dissolution—such as romantic breakups, divorce, and bereavement—have increased risk for poor health across a range of disease outcomes. However, it remains less clear which physiological pathways might best explain links between relationship dissolution and later health. One candidate mechanism that might help explain this wide range of observed health outcomes is accelerated biological aging, which is theorized to represent a common cause of age-related chronic diseases, disability, and early mort

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Jede, Christian, Laura J. Henze, Kirstin Meiners, Malte Bogdahn, Marcel Wedel, and Valeria van Axel. "Development and Application of a Dissolution-Transfer-Partitioning System (DTPS) for Biopharmaceutical Drug Characterization." Pharmaceutics 15, no. 4 (2023): 1069. http://dx.doi.org/10.3390/pharmaceutics15041069.

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A variety of in vitro dissolution and gastrointestinal transfer models have been developed aiming to predict drug supersaturation and precipitation. Further, biphasic, one-vessel in vitro systems are increasingly applied to simulate drug absorption in vitro. However, to date, there is a lack of combining the two approaches. Therefore, the first aim of this study was to develop a dissolution-transfer-partitioning system (DTPS) and, secondly, to assess its biopredictive power. In the DTPS, simulated gastric and intestinal dissolution vessels are connected via a peristaltic pump. An organic layer

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Omer, Asma B., Farhat Fatima, Mohammed Muqtader Ahmed, et al. "Enhanced Apigenin Dissolution and Effectiveness Using Glycyrrhizin Spray-Dried Solid Dispersions Filled in 3D-Printed Tablets." Biomedicines 11, no. 12 (2023): 3341. http://dx.doi.org/10.3390/biomedicines11123341.

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This study aimed to prepare glycyrrhizin–apigenin spray-dried solid dispersions and develop PVA filament-based 3D printlets to enhance the dissolution and therapeutic effects of apigenin (APN); three formulations (APN1–APN3) were proportioned from 1:1 to 1:3. A physicochemical analysis was conducted, which revealed process yields of 80.5–91% and APN content within 98.0–102.0%. FTIR spectroscopy confirmed the structural preservation of APN, while Powder-XRD analysis and Differential Scanning Calorimetry indicated its transformation from a crystalline to an amorphous form. APN2 exhibited improve

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Shivi, Kashyap*. "Drug Dissolution and Colour Cheque Monitoring in Acidic Dissolution of Domperidone Pellets Ip (Enteric Coated)." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3358–71. https://doi.org/10.5281/zenodo.15471925.

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Domperidone, a peripherally selective dopamine D2 receptor antagonist, is frequently prescribed for the treatment of gastrointestinal motility disorders, including nausea, vomiting, and delayed gastric emptying. Despite its therapeutic potential, its oral bioavailability remains a significant challenge due to its poor solubility and instability in acidic environments, such as the stomach. To overcome these limitations, pharmaceutical scientists have developed enteric-coated pellet formulations designed to bypass the gastric region and enable targeted release in the alkaline milieu of the small

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Alshamrani, Meshal, Muhammad Khalid Khan, Barkat Ali Khan, Ahmad Salawi, and Yosif Almoshari. "Technologies for Solubility, Dissolution and Permeation Enhancement of Natural Compounds." Pharmaceuticals 15, no. 6 (2022): 653. http://dx.doi.org/10.3390/ph15060653.

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The current review is based on the advancements in the field of natural therapeutic agents which could be utilized for a variety of biomedical applications and against various diseases and ailments. In addition, several obstacles have to be circumvented to achieve the desired therapeutic effectiveness, among which limited dissolution and/or solubility and permeability are included. To counteract these issues, several advancements in the field of natural therapeutic substances needed to be addressed. Therefore, in this review, the possible techniques for the dissolution/solubility and permeabil

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Qian, Kaijie, Lorenzo Stella, David S. Jones, Gavin P. Andrews, Huachuan Du, and Yiwei Tian. "Drug-Rich Phases Induced by Amorphous Solid Dispersion: Arbitrary or Intentional Goal in Oral Drug Delivery?" Pharmaceutics 13, no. 6 (2021): 889. http://dx.doi.org/10.3390/pharmaceutics13060889.

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Among many methods to mitigate the solubility limitations of drug compounds, amorphous solid dispersion (ASD) is considered to be one of the most promising strategies to enhance the dissolution and bioavailability of poorly water-soluble drugs. The enhancement of ASD in the oral absorption of drugs has been mainly attributed to the high apparent drug solubility during the dissolution. In the last decade, with the implementations of new knowledge and advanced analytical techniques, a drug-rich transient metastable phase was frequently highlighted within the supersaturation stage of the ASD diss

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Liu, Yue, Qing Wei, Ze-Yu Wang, Peng Xiang, Long-Ji Du, and Bai-Yong Fu. "A Novel Bond Anchor for Unidirectional FRP Member: Conceptual Design and Experimental Investigation." Advances in Materials Science and Engineering 2021 (July 19, 2021): 1–14. http://dx.doi.org/10.1155/2021/2666478.

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Fiber-reinforced polymer (FRP) is an advanced composite material with many advantages including light weight, high strength, and high fatigue and corrosion resistance, which makes unidirectional FRP suitable for tension members, such as cables, prestressing tendons, and tie rods. However, the unidirectional FRP is a typical isotropic material, which is difficult to be anchored and hence unable to give full play to the advantages of FRP. To solve the anchoring problem of unidirectional FRP member, a novel bond anchor, i.e., dissolution-rebond anchor, is proposed in this paper. In this novel anc

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Kößler, Reinhart. "Tradition und Reproduktion." PROKLA. Zeitschrift für kritische Sozialwissenschaft 25, no. 101 (1995): 587–602. http://dx.doi.org/10.32387/prokla.v25i101.944.

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The notion of the dissolution of 'traditional' sectors in the capitalist core countries only after the Second World War is critiqued, referring to social historical data, mainly of England and Germany during the 19th and 20th centuries. As a theoretical alternative for an understanding of social and especially of household reproduction, the concept of co-existing innovative spheres under capitalism is advanced.

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Whitley, Andrew, Fran Adar, and Ruth Geiger. "Advanced Raman Spectroscopy for Pharmaceutical and Biological Applications." Microscopy and Microanalysis 7, S2 (2001): 156–57. http://dx.doi.org/10.1017/s1431927600026854.

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With the advent of easy to use analytical and research instrumentation the Raman technique has finally become accepted and is now widely used by pharmaceutical and biomedical companies. Applications range from simple polymorphic crystal form and protein studies to Raman mapping studies of active/excipient distribution and association that give a better understanding of drug dissolution and effectiveness. Examples of such work will be discussed.More recently with the growing confidence in the power of Raman spectroscopy pharmaceutical and biomedical companies have teamed with instrument compani

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JOACHIM, GLORIA. "The Birth and Dissolution of an Inflammatory Bowel Disease Support Group." Gastroenterology Nursing 21, no. 3 (1998): 119–24. http://dx.doi.org/10.1097/00001610-199805000-00004.

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Changki, Jeon, and Jang-Yeon Hwang. "Advanced Potassium-Sulfur Batteries Using High-Concentration Electrolytes and Sulfurized Polyacrylonitrile Cathodes." ECS Meeting Abstracts MA2024-02, no. 10 (2024): 5004. https://doi.org/10.1149/ma2024-02105004mtgabs.

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Potassium–sulfur (K–S) batteries are emerging as promising technology due to their cost-effectiveness and high theoretical energy density.1 However, traditional K–S batteries face two significant challenges: (1) uncontrollable of potassium polysulfide (KPS) dissolution into the liquid electrolyte, and (2) the highly chemical and electrochemical reactive of the K-metal anode that leads to dendrite growth. These issues cause critical performance degradation, result in sudden death. Herein, I introduce a high-areal capacity, unprecedented cycle life of K–S battery that incorporates a high-concent

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Luong, Tan, Aginmariya Kottarathil, Władysław Wieczorek, and Patrik Johansson. "Polysulfide Dissolution, Diffusion and Reaction in Concentrated Electrolytes." ECS Meeting Abstracts MA2025-01, no. 3 (2025): 185. https://doi.org/10.1149/ma2025-013185mtgabs.

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In Li-S batteries, polysulfide (PS) species inherently solvate in liquid electrolytes and thereby contribute to loss of/unstable capacity and short battery life-spans. Increasing the electrolyte salt concentration is one approach to enhance cycling performance.1This is attributed to reduced PS solubility, as supported by physico-chemical characterization and modeling.2, 3 However, these methods do not provide any detailed insight into how PS species selectively dissolve, how they diffuse between the cathode and anode, and possibly undergo (electro)chemical reactions during discharge/charge cyc

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Chien, Ying Hsueh Chang, Matt Yeh, Scott Ku, et al. "Physical Cleaning Enhancement Using Advanced Spray with Uniform Droplet Control." Solid State Phenomena 195 (December 2012): 195–97. http://dx.doi.org/10.4028/www.scientific.net/ssp.195.195.

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In semiconductor device manufacturing, single wafer processors are widely used in not only BEOL process but also in FEOL process for 2X devices to improve the cleaning efficiency and get the higher productivity. Because the scaled down devices require the minimum substrate loss in the cleaning steps, the physical force by a dual fluid spray is still the main position to improve the cleaning efficiency at the moment comparing with chemical effects as the dissolution of contaminants and/or the lift off of particles. Sato, et al., reported that the relationship between particle removal and drople

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