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Journal articles on the topic 'Advanced treatment protocols'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Zhao, Tiping, Genxiong Ding, Haoyong Gao, Zhenzhou Shen, and Katherine Li Yueyun. "A Clinical Trial of Homoharringtonine in the Treatment of Advanced Breast Cancer." Tumori Journal 72, no. 4 (1986): 395–98. http://dx.doi.org/10.1177/030089168607200409.

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Two combination chemotherapy protocols, CMF (cyclophosphamide, methotrexate, fluorouracil) and CMFH (CMF plus homoharringtonine), were tested in advanced breast cancer patients. The response rate of CMF was 50% in 44 cases, and that of CMFH was 54.16% in 48 cases; the difference was not significant. There was also no difference between the median duration of response and the median survival of the two protocols. It was concluded that the addition of homoharringtonine to the CMF protocol gave no additional benefit.

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Herchenhorn, Daniel, and Fernando Luiz Dias. "Advances in radiochemotherapy in the treatment of head and neck cancer." Revista do Hospital das Clínicas 59, no. 1 (2004): 39–46. http://dx.doi.org/10.1590/s0041-87812004000100007.

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New advances are being incorporated into the radiochemotherapy treatment of squamous cell carcinoma of the head and neck. Although the overall prognosis is poor in advanced stages, the possibility of incorporating combined protocols of chemotherapy and radiotherapy for organ preservation or for palliation in cases of recurrent/locally advanced stages that are not good surgical candidates must not be forgotten. In this context, there is an urgent need to incorporate quality of life questionnaires and functional evaluation into organ-preservation studies, as well as to assure the importance of s

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Stojadinović, Milica, Dragan Mašulović, Marko Kadija, et al. "Optimization of the “Perth CT” Protocols for Preoperative Planning and Postoperative Evaluation in Total Knee Arthroplasty." Medicina 60, no. 1 (2024): 98. http://dx.doi.org/10.3390/medicina60010098.

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Background and Objectives: Total knee arthroplasty (TKA) has become the treatment of choice for advanced osteoarthritis. The aim of this paper was to show the possibilities of optimizing the Perth CT protocol, which is highly effective for preoperative planning and postoperative assessment of alignment. Materials and Methods: The cross-sectional study comprised 16 patients for preoperative planning or postoperative evaluation of TKA. All patients were examined with the standard and optimized Perth CT protocol using advance techniques, including automatic exposure control (AEC), iterative image

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Vujkov, Tamara, Milica Zivaljevic, Petar Novakovic, Marko Erak, Jelka Rajovic, and Aljosa Mandic. "Treatment protocols for cervical cancer." Medical review 55, no. 3-4 (2002): 105–8. http://dx.doi.org/10.2298/mpns0204105v.

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Introduction Cervical cancer is the second most common cancer in women worldwide and the second cause of cancer death among women. About 95% (90% in developed countries) of invasive carcinomas are of sqamous types, and 5% (10% in developed countries) are adenocarcinomas. FIGO classification of cervical carcinomas, based on clinical staging and prognostic factor dictate therapeutic procedures and help in designing treatment protocols. Therapeutic modalities Surgical therapy includes conization, radical hysterectomy with pelvic lymphadenectomy and palliative operation urinary diversion and colos

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Mekic-Abazovic, Alma, Ibrahim Sisic, Vladimir Kovcin, Hakija Beculic, Senad Dervisevic, and Miralem Music. "Comparison of efficiency and toxicity of two chemotherapy protocols in treatment of advanced non-small cell lung cancer." Medical review 64, no. 7-8 (2011): 368–72. http://dx.doi.org/10.2298/mpns1108368m.

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Introduction. This study was aimed at comparing the efficiency and tolerability of two reference protocols Cisplatin and Etoposide and Cisplatin and Vinorelbine in advanced Non-Small Cell Lung Cancer. Material and Methods. A total of 60 patients (two groups consisting of 30 patients) were treated for advanced Non-Small Cell Lung Cancer during the period from January to December 2005 according to the reference protocols (Cisplatin 100mg/m2 D1; Vinorelbine 30 mg/m2 D1, D8 on 4 weeks) and (Cisplatin 100 mg/m2 D1; Etoposide 100 mg/m2 D1, D3, D5 on 4 weeks) at the Department of Oncology of KBC ?Bez

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Günther, Felix. "Modeling advanced security aspects of key exchange and secure channel protocols." it - Information Technology 62, no. 5-6 (2020): 287–93. http://dx.doi.org/10.1515/itit-2020-0029.

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AbstractSecure connections are at the heart of today’s Internet infrastructure, protecting the confidentiality, authenticity, and integrity of communication. Achieving these security goals is the responsibility of cryptographic schemes, more specifically two main building blocks of secure connections. First, a key exchange protocol is run to establish a shared secret key between two parties over a, potentially, insecure connection. Then, a secure channel protocol uses that shared key to securely transport the actual data to be exchanged. While security notions for classical designs of these co

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Cunha, S. C. S., M. M. André, K. B. Corgozinho, K. V. G. C. Silva, C. A. Silva, and A. M. R. Ferreira. "Radiation therapy for advanced canine nasal planum squamous cell carcinoma: case report." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 72, no. 1 (2020): 119–24. http://dx.doi.org/10.1590/1678-4162-11157.

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ABSTRACT This case report describes the outcome of treatment of dogs with advanced (deeply invasive) nasal planum squamous cell carcinomas with palliative or definitive radiation therapy. All dogs were diagnosed with nasal planum squamous cell carcinoma by histopathology, and their owners declined aggressive surgery. Dogs were treated with a cobalt-60 unit, definitive-intent radiation protocol consisting of 15 daily fractions (Monday-Friday) of 2.8 Gy, and palliative radiation protocol consisting of 4 fractions of 8 Gy performed once a week. Three dogs had T3 tumors and three had T4 tumors acc

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Uckun, S. "Instantiating and Monitoring Skeletal Treatment Plans." Methods of Information in Medicine 35, no. 04/05 (1996): 324–33. http://dx.doi.org/10.1055/s-0038-1634679.

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Abstract:Current emphasis on protocol-based care has stirred interest in planning research as applied to clinical medicine. However, many assumptions made in designing traditional planners and plan-execution algorithms do not hold in medical domains. The problems include the unpredictable nature of the domain, uncertainty and the variability in the utility of available actions, and the need for parallel and continuous execution of treatment plans. In the context of our research on intelligent monitoring and control, we developed an approach for plan instantiation and execution which takes adva

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Di Nardo, Paola, Silvio Ken Garattini, Elena Torrisi, et al. "Systemic Treatments for Advanced Small Bowel Adenocarcinoma: A Systematic Review." Cancers 14, no. 6 (2022): 1502. http://dx.doi.org/10.3390/cancers14061502.

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Small bowel adenocarcinoma (SBA) is a rare disease for which scarce evidence is available. We summarized data available on systemic treatment of advanced SBA. Methods: Scientific literature was evaluated to find phase II or phase III clinical trials on systemic treatment for advanced SBA. MeSH terms were selected and combined for the initial search, then inclusion and exclusion criteria were set in a search protocol. Four medical oncologists looked for evidence on Medline, EMBASE and Cochrane databases. Moreover, abstracts from 2016 to June 2021 from the American Society for Clinical Oncology,

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Sparano, Clotilde, Sophie Moog, Julien Hadoux, et al. "Strategies for Radioiodine Treatment: What’s New." Cancers 14, no. 15 (2022): 3800. http://dx.doi.org/10.3390/cancers14153800.

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Radioiodine treatment (RAI) represents the most widespread and effective therapy for differentiated thyroid cancer (DTC). RAI goals encompass ablative (destruction of thyroid remnants, to enhance thyroglobulin predictive value), adjuvant (destruction of microscopic disease to reduce recurrences), and therapeutic (in case of macroscopic iodine avid lesions) purposes, but its use has evolved over time. Randomized trial results have enabled the refinement of RAI indications, moving from a standardized practice to a tailored approach. In most cases, low-risk patients may safely avoid RAI, but wher

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Figueiredo, André, Diogo Delgado, Helena Luna Pais, and Maria Filomena De Pina. "MacDonald versus MAGIC treatment protocols for gastric cancer: age as a decision factor." International Journal of Advances in Medicine 7, no. 2 (2020): 190. http://dx.doi.org/10.18203/2349-3933.ijam20200005.

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Background: A multimodality approach is the standard of care in the treatment of locally advanced non-metastatic gastric cancer. However, it lacks studies that compares the adjuvant chemoradiotherapy strategy of the landmark MacDonald clinical trial with the perioperative chemotherapy strategy of the landmark MAGIC clinical trial.Methods: Retrospective study of patients with gastric cancer stage IB-III treated at a single cancer center between 2010 and 2013 with MacDonald or MAGIC treatment protocols.Results: Sixty-two patients were identified (38 patients in the MacDonald protocol and 24 in t

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Pitino, Alberto, Francesco Gianfreda, Alessandro Dolci, et al. "A step-by-step technical report on the novel 'PREMADE Protocol' for fabricating acrylic provisional prostheses for all-on-4 treatment concept." Oral & Implantology 16, no. 3 (2024): 133–39. https://doi.org/10.11138/oi.v16i3.60.

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Background: This technical report describes how to use a prosthetic protocol with a standardized immediate and fixed prosthesis that is the same for all patients. The prosthesis called “PREMADE” is adapted to various arch sizes (narrow, regular, and wide, with uniform teeth in all cases). This aim is to obviate the need for all laboratory procedures following the positioning of the implant. Case Presentation: This report details the application of the PREMADE protocol in a clinical setting. It illustrates its use in a patient requiring immediate dental implant loading, highlighting the protoco

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Pitino, Alberto, Francesco Gianfreda, Alessandro Dolci, et al. "A step-by-step technical report on the novel 'PREMADE Protocol' for fabricating acrylic provisional prostheses for all-on-4 treatment concept." Oral & Implantology 16, no. 3 (2024): 133–39. https://doi.org/10.11138/oi163133-139.

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Background: This technical report describes how to use a prosthetic protocol with a standardized immediate and fixed prosthesis that is the same for all patients. The prosthesis called “PREMADE” is adapted to various arch sizes (narrow, regular, and wide, with uniform teeth in all cases). This aim is to obviate the need for all laboratory procedures following the positioning of the implant. Case Presentation: This report details the application of the PREMADE protocol in a clinical setting. It illustrates its use in a patient requiring immediate dental implant loading, highlighting the protoco

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14

Zrelak, Patricia. "Evolving Evidence Practices in Acute Stroke Care." International Journal of Critical Care 18, no. 4 (2024): 51. https://doi.org/10.29173/ijcc1041.

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Acute ischemic stroke care is experiencing a transformative shift, driven by emerging evidence supporting optimized thrombolytic strategies, extended treatment windows, and advanced imaging protocols. Recent clinical trials have demonstrated the non-inferiority—and, in certain aspects, superiority—of tenecteplase over alteplase. With its simplified single bolus administration, enhanced fibrin specificity, and potential for improved recanalization rates, tenecteplase is increasingly recognized as a preferred first-line thrombolytic agent in many treatment algorithms. Additionally, streamlined t

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Urbánková, Pavla, Břetislav Gál, Marek Slávik, Mária Štrbová, and Libor Urbánek. "Significance and indications of total laryngectomy in modern laryngeal oncology." Otorinolaryngologie a foniatrie 74, no. 2 (2025): 117–22. https://doi.org/10.48095/ccorl2025117.

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Preserving a functional larynx and achieving long-term control is the basic postulate of treating patients with malignant tumors of the larynx, even in advanced stages. Therefore, non-surgical treatment protocols and larynx-preserving surgical procedures are preferred. Total laryngectomy is historically the basic procedure of laryngeal surgery still with the best survival outcomes in advanced laryngeal cancer, but with signifi cantly lower quality of life fol lowing surgery. Nevertheless, there are still groups of patients who can benefi t from this implementation. Local and overall characteri

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Eckers, Franziska, Stefan Loske, Eugene T. Ek, and Andreas M. Müller. "Current Understanding and New Advances in the Surgical Management of Reparable Rotator Cuff Tears: A Scoping Review." Journal of Clinical Medicine 12, no. 5 (2023): 1713. http://dx.doi.org/10.3390/jcm12051713.

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Rotator cuff (RC) tears are among the most common musculoskeletal disorders and can be associated with pain, weakness, and shoulder dysfunction. In recent years, there have been significant advances with regard to the understanding of rotator cuff disease and its management. With technological improvements and advanced diagnostic modalities, there has been much progress as to improved understanding of the pathology. Similarly, with advanced implant designs and instrumentation, operative techniques have evolved. Furthermore, refinements in postoperative rehabilitation protocols have improved pa

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Keane, Grace, Rob van Rooij, Marnix Lam, Arthur Braat, Maarten Smits, and Hugo de Jong. "An Evaluation of 90Y Bremsstrahlung SPECT Image Quality in the Presence of 99mTc: A Technical Perspective on Same-Day Radioembolization." Current Oncology 31, no. 12 (2024): 7511–22. http://dx.doi.org/10.3390/curroncol31120554.

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In same-day radioembolization, 99mTc-MAA SPECT/CT, 90Y radioembolization, and post-treatment 90Y SPECT/CT procedures are conducted on the same-day, resulting in a dual-isotope environment of 90Y and 99mTc during post-treatment imaging. This study aimed to quantify the impact of 99mTc on 90Y bremsstrahlung-SPECT/CT image quality and to establish an optimised imaging protocol for both clinical practice, and with advanced reconstruction techniques. Utilising a NEMA IQ phantom, contrast recovery coefficients (CRCs) were measured to evaluate the 90Y image quality degradation caused by 99mTc. SPECT/

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Andric, Zoran, Tomislav Randjelovic, Vladimir Kovcin, et al. "Evaluation of the efficacy and toxicity of protocol cisplatin, 5-fluorouracil, leucovorin compared to protocol fluorouracil, doxorubicin and mitomycin C in locally advanced and metastatic gastric cancer." Srpski arhiv za celokupno lekarstvo 140, no. 5-6 (2012): 305–12. http://dx.doi.org/10.2298/sarh1206305a.

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Introduction. Still there is no consensus on the choice of the most efficient and the least toxic chemotherapy regimen in the treatment of advanced gastric cancer. Nowadays few therapy protocols are available for treating this disease. Objective. Study was conducted to compare the efficacy and toxicity of FAM (flurouracil, doxorubicin, mitomycin C) with CDDP and FU/FA (cisplatin, 5-fluorouracil, leucovorin) protocols in patients with locally advanced and metastatic gastric cancer. Methods. This randomized study involved a group of 50 patients with locally advanced or metastatic gastric cancer,

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Evdochim, Lucian, Adrian Florescu, and Lidia Dobrescu. "Roadmap of Photoplethysmography Technology in Advanced Cardiovascular Assessment." Romanian Journal of Military Medicine 127, no. 5 (2024): 405–11. http://dx.doi.org/10.55453/rjmm.2024.127.5.10.

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This review explores the trajectory of photoplethysmography (PPG) technology from its inception in 1934 to its integration into smart devices in 2013. While PPG has proven effective in estimating left ventricular ejection time (LVET) and distinguishing between hypertensive and normotensive patients, challenges persist. The need for a robust mathematical model to explain physiological behaviors, address calibration protocols, and handle waveform variability is emphasized. Despite limitations, PPG is on the cusp of achieving clinical-grade confidence, particularly in estimating blood pressure an

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Riva, Giuseppe, and Giancarlo Pecorari. "Editorial for the Special Issue on Multimodality and Sequential Therapy in Locally Advanced Head and Neck Cancer." Cancers 14, no. 17 (2022): 4247. http://dx.doi.org/10.3390/cancers14174247.

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Multimodal and sequential treatment for locally advanced head and neck cancer (HNC) included induction chemotherapy, chemoradiation organ preservation protocols, immunotherapy, and targeted therapy [...]

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Rabe, Sarah B., and Gretchen D. Oliver. "Clavicular Fracture in a Collegiate Football Player: A Case Report of Rapid Return to Play." Journal of Athletic Training 46, no. 1 (2011): 107–11. http://dx.doi.org/10.4085/1062-6050-46.1.107.

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Abstract Objective: To present the case of surgical treatment and rehabilitation of a midshaft clavicular fracture in a National Collegiate Athletic Association Division I football athlete. Background: While attempting to catch a pass during practice, the athlete jumped up and then landed on the tip of his shoulder. On-the-field evaluation was inconclusive, with a sideline evaluation diagnosis of clavicular fracture. Postinjury radiographs revealed a midshaft clavicular fracture. Differential Diagnosis: Spiral oblique midshaft clavicular fracture. Treatment: The sports medicine staff discussed

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Ji, Jianrui, Yunsong Liu, Yongxing Bao, Yu Men, Jun Wang, and Zhouguang Hui. "Review of radiotherapy combined with systemic therapy for advanced esophageal cancer: from chemotherapy to immunotherapy era." Visualized Cancer Medicine 6 (2025): 5. https://doi.org/10.1051/vcm/2025004.

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Advanced esophageal cancer is characterized by poor prognosis and high recurrence rates, even after receiving standard radical treatments. Current treatment guidelines primarily recommend systemic therapy combined with palliative and supportive care for advanced esophageal cancer, particularly in patients with limited functional status. Despite the recent advances, including the introduction of immunotherapy, overall survival of these patients remains limited. Radiotherapy, traditionally used for palliative purposes, is increasingly being explored as an adjunct to systemic therapies, including

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Bruno, Giacomo, Thomas Geninatti, R. Lyle Hood, et al. "Leveraging electrokinetics for the active control of dendritic fullerene-1 release across a nanochannel membrane." Nanoscale 7, no. 12 (2015): 5240–48. http://dx.doi.org/10.1039/c4nr06209d.

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Seidel, Sabine, and Uwe Schlegel. "Have treatment protocols for primary CNS lymphoma advanced in the past 10 years." Expert Review of Anticancer Therapy 19, no. 10 (2019): 909–15. http://dx.doi.org/10.1080/14737140.2019.1677157.

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Tetzlaff, E. D., J. Baker, and J. A. Ajani. "Incidence of thromboembolic events (TEEs) before and during chemotherapy of patients with advanced gastric and gastroesophageal junction carcinoma (AG-GEJC) on clinical trials." Journal of Clinical Oncology 24, no. 18_suppl (2006): 4073. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.4073.

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4073 Background: TEEs are associated with AG-GEJC and chemotherapy can further increase its incidence. We assessed TEEs before and during protocol chemotherapy for AG-GEJC patients. Methods: Patients with AG-GEJC on four approved protocols between August 1997 and September 2003 were assessed for baseline TEEs, new TEEs during therapy, histology, location of the primary, and overall survival. Three protocols evaluated camptothecin-based chemotherapy (irinotecan, peg-camptothecin, and rubitecan) and one evaluated non-camptothecin-based chemotherapy. Results: We studied 191 patients. Median age w

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Sabatini, Silvia, Matteo Castaldi, Adriana Assunta De Stefano, Gabriella Galluccio, Roberta Grassi, and Gianna Maria Nardi. "Protocols and Technologies Used by Italian Dental Professionals to Maintain Good Oral Health in Orthodontic Patients Before, During and After Treatment: A Survey Study." Oral 5, no. 1 (2025): 9. https://doi.org/10.3390/oral5010009.

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Background: Orthodontic appliances increase biofilm accumulation by expanding plaque retention sites. Enamel demineralization and periodontal inflammation are considered to be the most prevalent consequences of biofilm formation in orthodontic patients, with reported prevalence rates of up to 50%. To date, there are different procedures and indications that have been used for the treatment of these conditions. Therefore, professionals may use different technologies and protocols to control bacterial biofilm. The aim of this study was to investigate the protocols and technologies used by Italia

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Gioia, Laura C., Alexandre Y. Poppe, Roxanne Laroche, et al. "Streamlined Poststroke Treatment Order Sets During the SARS-CoV-2 Pandemic." Stroke 51, no. 10 (2020): 3115–18. http://dx.doi.org/10.1161/strokeaha.120.031008.

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Background and Purpose: Standard poststroke treatment monitoring protocols are made problematic during the coronavirus disease 2019 (COVID-19) pandemic by the frequency of patient assessments, requiring repeated donning and doffing procedures in a short interval of time. Methods: A streamlined poststroke treatment protocol was developed to limit frequency of patient encounters while maximizing the yield of each encounter by grouping together different components of poststroke care into single bedside visits. Results: Streamlined order sets were developed late March 2020. During the first 6 wee

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Miron, Oana Tatiana, Anca Maria Adavidoaiei, Vlad-Adrian Afrasanie, Doina Mihaila, and Ingrith Miron. "UPDATES ON THE DIAGNOSIS AND TREATMENT OF PEDIATRIC HEPATOBLASTOMA WITH PULMONARY METASTASES." Romanian Journal of Pediatrics 65, no. 1 (2016): 67–71. http://dx.doi.org/10.37897/rjp.2016.1.14.

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Although the frequency of hepatoblastoma is low, it is the most common primary malignant liver tumor in children. The prognosis of the disease has improved considerably in the last decades due to oncological and surgical treatment advances. Nonetheless, tumors which are diagnosed at an advanced stage still have a poor prognosis. We present the case of a 33-month-old child, diagnosed with high-risk hepatoblastoma (pulmonary metastases) in February 2014. Surgery was performed and the tumor completely removed. Afterwards, chemotherapy treatment was initiated according to a modified SIOPEL-4 proto

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Turri, Giulia, Giovanni Ostuzzi, Giovanni Vita, et al. "Treatment of Locally Advanced Rectal Cancer in the Era of Total Neoadjuvant Therapy." JAMA Network Open 7, no. 6 (2024): e2414702. http://dx.doi.org/10.1001/jamanetworkopen.2024.14702.

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ImportanceTreatment of locally advanced rectal cancer (LARC) involves neoadjuvant chemoradiotherapy plus total mesorectal excision and adjuvant chemotherapy. However, total neoadjuvant therapy (TNT) protocols (ie, preoperative chemotherapy in addition to radiotherapy) may allow better adherence and early treatment of distant micrometastases and may increase pathological complete response (pCR) rates.ObjectiveTo assess the efficacy and tolerability of TNT protocols for LARC.Data SourcesMEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science Core Collection

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Jeung, Tae Sig, Sun Young Ma, Jesang Yu, and Sangwook Lim. "Cases That Respond to Oncothermia Monotherapy." Conference Papers in Medicine 2013 (May 29, 2013): 1–12. http://dx.doi.org/10.1155/2013/392480.

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There is a long history of hyperthermia in oncology, but its wide range acceptance and application are missing even today. A new approach of oncological hyperthermia, oncothermia, looks promising modality of the complementary treatment of advanced malignant cases. Our present paper is targeting this method, trying to answer the question of its feasibility to treat various advanced cases in monotherapy process, as well as its applicability for a long, large number of treatment sessions protocols.

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Ersan, Fatma Gül, Hulya Yilmaz, Cagri Coskun, et al. "Drug-Induced Diabetes during Treatment of ALL in Children: Who Is at Risk and When?" Blood 144, Supplement 1 (2024): 5853. https://doi.org/10.1182/blood-2024-199258.

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Hyperglycemia is a prevalent metabolic disturbance during ALL treatment, with a reported incidence of 8-35% in children with ALL. It is most commonly related to high-dose glucocorticoids and asparaginase used in treatment protocols. The study was designed to examine the effects of different doses of glucocorticoids and asparaginase on the development of diabetes during ALL treatment; Answers were sought to the questions of who is more likely to get diabetes and when? 278 children who received ALL treatment between 2008 and 2023 were included in the study. 173 children received the Modified St

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Saadah, Alaa, Donald Medlin, Jad Saud, Levente Menyhárt, Xiaoran Zheng, and Géza Husi. "Developing Robust Safety Protocols for Radiosurgery within Patient Positioning System Framework." Machines 12, no. 2 (2024): 106. http://dx.doi.org/10.3390/machines12020106.

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This paper offers a comprehensive examination of the development and implementation of advanced safety protocols in the Patient Positioning System (PPS) for radiosurgery. In an era where precision and safety are increasingly crucial in medical procedures, particularly radiosurgery, the implementation of sophisticated safety measures in PPS is vital. This research delves into the detailed design of the system, emphasizing the sensor and controller mechanisms employed. A significant focus is placed on comparing single-loop and dual-loop control systems, assessing their impact on the precision, a

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Strauss, Carrie A., Jeffrey A. Kotzen, Ans Baeyens, and Irma Maré. "Oncothermia in HIV-Positive and -Negative Locally Advanced Cervical Cancer Patients in South Africa." Conference Papers in Medicine 2013 (May 26, 2013): 1–3. http://dx.doi.org/10.1155/2013/293968.

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Aim. Investigate the clinical, economic, and cellular effects of the addition of oncothermia to standard treatment for HIV-positive and -negative locally advanced cervical cancer patients in public healthcare in South Africa. Objectives. Evaluate the effect that the addition of oncothermia has on local disease control, progression-free survival, overall survival at 2 years, treatment toxicity, quality of life, economic impact, and HIV status of participants. Radiobiology investigations will evaluate thermoradiosensitivity and the molecular markers for thermoradiosensitivity. Methodology. Phase

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Grigorovici, Alexandru, Flore Varcus, Simona Mogos, et al. "Hypocalcemia after Thyroidectomy for Advanced Local Malignancies." Revista de Chimie 70, no. 3 (2019): 1053–57. http://dx.doi.org/10.37358/rc.19.3.7062.

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Postoperative hypoparathyroidism is most commonly caused by the extirpation, injury or devascularisation of parathyroid glands. The aim of this study is to establish correlations between the advanced thyroid cancer staging, the appropriate individual treatment, the results obtained, the frequency and intensity of transient and/or permanent post-operative hypocalcemia. The present study can be continued with further researches in order to improve and develop surgical, oncological and endocrine management protocols for patients diagnosed with advanced thyroid cancer and also to avoid these relat

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Büchert, Martin, and Klaus Mross. "Ir-truefisp: A New Dce-mri Approach in Comparison with 3d-flash Multi Flip Angle Method." Magnetic Resonance Insights 5 (January 2012): MRI.S9832. http://dx.doi.org/10.4137/mri.s9832.

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For assessing treatment response to novel cancer therapeutics, dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is a valuable tool. Quantitative functional parameter estimates can be obtained by fitting physiological models to the data. In this study the IR-TrueFISP approach was evaluated as DCE-MRI acquisition sequence against the widely used 3D-Flash protocol. For comparison both protocols providing different spatial and temporal information were investigated in phantom and patient examinations. 12 advanced tumor patients underwent two examinations on consecutive days using bot

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Tomatis, Stefano, Pietro Mancosu, Giacomo Reggiori, et al. "Twenty Years of Advancements in a Radiotherapy Facility: Clinical Protocols, Technology, and Management." Current Oncology 30, no. 7 (2023): 7031–42. http://dx.doi.org/10.3390/curroncol30070510.

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Background: Hypo-fractionation can be an effective strategy to lower costs and save time, increasing patient access to advanced radiation therapy. To demonstrate this potential in practice within the context of temporal evolution, a twenty-year analysis of a representative radiation therapy facility from 2003 to 2022 was conducted. This analysis utilized comprehensive data to quantitatively evaluate the connections between advanced clinical protocols and technological improvements. The findings provide valuable insights to the management team, helping them ensure the delivery of high-quality t

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Komalasari, Rita. "Optimizing Prostate Cancer Radiotherapy: Advanced Machine Learning in Virtual Patient-Specific Plan Verification-Review Study." Indonesian Journal of Cancer 18, no. 3 (2024): 362–67. http://dx.doi.org/10.33371/ijoc.v18i3.1128.

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Background: Virtual patient-specific plan verification in radiotherapy is critical to ensure precise dose delivery while minimizing healthy tissue exposure, particularly in prostate cancer treatments. Prior studies, however, have overlooked the physical implications of predictor features and lacked comprehensive decision support tools, leading to gaps in understanding and practical application. This research aims to bridge these gaps by providing a nuanced understanding of predictor features, exploring advanced automatic feature extraction methods, emphasizing model reliability, and proposing

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Massobrio, Roberta, Lavinia Bianco, Beatrice Campigotto, et al. "New Frontiers in Locally Advanced Cervical Cancer Treatment." Journal of Clinical Medicine 13, no. 15 (2024): 4458. http://dx.doi.org/10.3390/jcm13154458.

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Despite the introduction of targeted vaccines and screening protocols, locally advanced cervical cancer represents a median proportion of 37% among all cervical carcinomas. Compared to early stages, it presents significantly lower cure rates, with a 5-year disease-free survival rate of 68% and a 5-year overall survival rate of 74%. According to current guidelines, definitive radiotherapy with concomitant chemotherapy represents the gold standard for locally advanced cervical cancer treatment. However, a significant number of patients relapse and die from metastatic disease. The aim of this nar

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Gajjar, Amar, Daniel C. Bowers, Matthias A. Karajannis, Sarah Leary, Hendrik Witt, and Nicholas G. Gottardo. "Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape." Journal of Clinical Oncology 33, no. 27 (2015): 2986–98. http://dx.doi.org/10.1200/jco.2014.59.9217.

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Pediatric neuro-oncology has undergone an exciting and dramatic transformation during the past 5 years. This article summarizes data from collaborative group and institutional trials that have advanced the science of pediatric brain tumors and survival of patients with these tumors. Advanced genomic analysis of the entire spectrum of pediatric brain tumors has heralded an era in which stakeholders in the pediatric neuro-oncology community are being challenged to reconsider their current research and diagnostic and treatment strategies. The incorporation of this new information into the next-ge

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Alshagag, Zainab Abdullah, ‏Hamad Marshud Alotaibi, ‏Bander Khalid Baurasien, et al. "A comprehensive narrative review of traumatic cardiac arrest." International journal of health sciences 8, S1 (2024): 1142–56. http://dx.doi.org/10.53730/ijhs.v8ns1.15132.

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Background: Traumatic cardiac arrest (TCA) has historically been viewed as largely untreatable, with low survival rates and limited intervention strategies. Advances in understanding the pathophysiology of TCA, improvements in diagnostic and therapeutic technologies, and refinements in treatment protocols have shifted this perspective. This review focuses on the implications of these advancements for paramedics involved in emergency management and treatment strategies for TCA. Aim: To provide a comprehensive review of current insights into TCA management, with a particular emphasis on the role

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Negosanti, Luca, Siriana Landi, Micaela Battilana, Ruben Pondrelli, and Rossella Sgarzani. "Surgical Treatment of Pressure Injures in Spinal Cord Injury Patients: Incidence of Surgical Complications and Tips for Prevention." Complications 2, no. 2 (2025): 15. https://doi.org/10.3390/complications2020015.

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Background: People with spinal cord injury/disorder are at a high risk of pressure injury formation, and, in advanced cases, surgery is mandatory. These patients present specific clinical aspects to consider in order to reduce the risk of complications. This paper is a narrative review and expert opinion based on the authors’ institutional experience of over 10 years in a spinal unit. The specific protocols of treatment based on a multidisciplinary approach, protocols of flap selection, and strategies to prevent and manage complications are reviewed. The specific clinical aspects of each patie

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Sierra-Sánchez, Álvaro, Martin A. Barbier, Brice Magne, Danielle Larouche, Salvador Arias-Santiago, and Lucie Germain. "Comparison of Two Human Skin Cell Isolation Protocols and Their Influence on Keratinocyte and Fibroblast Culture." International Journal of Molecular Sciences 24, no. 19 (2023): 14712. http://dx.doi.org/10.3390/ijms241914712.

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For the development of advanced therapies, the use of primary cells instead of cell lines is preferred. The manufacture of human tissue-engineered skin substitutes requires efficient isolation and culture protocols allowing a massive expansion of the cells in culture from an initial specimen of a minimal size. This study compared two skin cell isolation protocols, routinely applied in two clinical laboratories. Epithelial (keratinocytes) and dermal (fibroblasts) cells were isolated and cultured from three human skin biopsies (N = 3). The two-step digestion protocol (LOEX-Protocol) firstly used

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Kale, Sachin, Sanjay Dhar, Pramod Bhor, Ashish Phadnis, Arvind Vatkar, and Rohan Jayaram. "Emerging Trends in Distal Femur Fracture Treatment Modalities – A Narrative Review." Journal of Orthopaedic Case Reports 15, no. 3 (2025): 215–19. https://doi.org/10.13107/jocr.2025.v15.i03.5392.

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Introduction: Recent advancements in the treatment of distal femoral fractures have significantly shifted toward more advanced fixation techniques and approaches. The variety of fracture patterns across different age groups complicates the establishment of a standardized treatment protocol upon presentation, thus making it difficult to establish defined protocols to follow in routine clinical practice. Materials And Methods:This review analyzes existing literature and research studies on traditional methods, such as plating, intramedullary nailing, and distal femoral replacement, alongside eme

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Hu, Yunfei, Marius Arnesen, and Trent Aland. "Characterization of an advanced cone beam CT (CBCT) reconstruction algorithm used for dose calculation on Varian Halcyon linear accelerators." Biomedical Physics & Engineering Express 8, no. 2 (2022): 025023. http://dx.doi.org/10.1088/2057-1976/ac536b.

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Abstract In this study, the performance of a new iterative reconstruction algorithm, the pre-clinical AcurosXB iCBCT algorithm, has been characterized on Varian Halcyon linear accelerators with respect to the potential of radiotherapy dose calculations on CBCT images. The study utilized various phantom setups to verify the accuracy of the pre-clinical algorithm under different scatter conditions and compared dose calculations performed on CBCT images reconstructed with the pre-clinical algorithm to those performed on typical planning CT images. The results indicated that despite showing improv

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Mueller, R., E. Rahm, J. Ramsch, B. Heller, M. Loeffler, and U. Greiner. "AdaptFlow: Protocol-based Medical Treatment Using Adaptive Workflows." Methods of Information in Medicine 44, no. 01 (2005): 80–88. http://dx.doi.org/10.1055/s-0038-1633926.

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Summary Objectives: In many medical domains investigator-initiated clinical trials are used to introduce new treatments and hence act as implementations of guideline-based therapies. Trial protocols contain detailed instructions to conduct the therapy and additionally specify reactions to exceptional situations (for instance an infection or a toxicity). To increase quality in health care and raise the number of patients treated according to trial protocols, a consultation system is needed that supports the handling of the complex trial therapy processes efficiently. Our objective was to design

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Chen, Ching-Tso, Tsung-Hao Liu, Yu-Yun Shao, Kao-Lang Liu, Po-Chin Liang, and Zhong-Zhe Lin. "Revisiting Hepatic Artery Infusion Chemotherapy in the Treatment of Advanced Hepatocellular Carcinoma." International Journal of Molecular Sciences 22, no. 23 (2021): 12880. http://dx.doi.org/10.3390/ijms222312880.

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Hepatic artery infusion chemotherapy (HAIC) is a well-established and common treatment for advanced hepatocellular carcinoma (HCC), particularly in East Asia. However, HAIC is not recognized internationally. Although several trials have demonstrated the safety and efficacy of HAIC, evidence corroborating its overall survival (OS) benefits compared with standard treatments is insufficient. Nevertheless, HAIC may provide prominent benefits in selected patients such as patients with portal vein thrombosis or high intrahepatic tumor burden. Moreover, HAIC has been combined with several therapeutic

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Suo, Zhangyao, Anrui Li, Xueyan Li, et al. "Research Progress on the Role of Biochar in COD Degradation in Wastewater." International Journal of Natural Resources and Environmental Studies 5, no. 3 (2025): 237–44. https://doi.org/10.62051/ijnres.v5n3.26.

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Biochar has emerged as a promising eco-friendly material for addressing chemical oxygen demand (COD) in wastewater treatment, offering sustainable alternatives to conventional purification methods. This review systematically examines its multifunctional roles through physicochemical characteristics including developed surface area, porous structure, and surface functional groups that collectively enable effective COD removal via adsorption, catalytic degradation, and microbial interactions. The oxidation-reduction reactions facilitated by persistent free radicals and oxygen-containing function

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Pandya, Vidish, Akhil Avunoori Chandra, Andrea Scotti, et al. "Evolution of Pulmonary Embolism Response Teams in the United States: A Review of the Literature." Journal of Clinical Medicine 13, no. 13 (2024): 3984. http://dx.doi.org/10.3390/jcm13133984.

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Pulmonary embolism (PE) is a significant cause of cardiovascular mortality, with varying presentations and management challenges. Traditional treatment approaches often differ, particularly for submassive/intermediate-risk PEs, because of the lack of clear guidelines and comparative data on treatment efficacy. The introduction of pulmonary embolism response teams (PERTs) aims to standardize and improve outcomes in acute PE management through multidisciplinary collaboration. This review examines the conception, evolution, and operational mechanisms of PERTs while providing a critical analysis o

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Hsu, Fu-Shun, Chun-Hung Su, and Kou-How Huang. "A Comprehensive Review of US FDA-Approved Immune Checkpoint Inhibitors in Urothelial Carcinoma." Journal of Immunology Research 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/6940546.

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Few effective treatment options are available for patients with advanced or metastatic urothelial carcinoma (UC) after unsuccessful first-line platinum-based chemotherapy. To date, immune checkpoint inhibitors are novel therapeutic agents for UC treatment. From May 2016 to May 2017, five anti-PD-1/PD-L1 monoclonal antibodies received accelerated or regular approval from the US Food and Drug Administration (FDA) for the treatment of patients with locally advanced or metastatic UC. The present comprehensive review presents the background information of these five US FDA-approved anticancer agent

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Hasina, Kaniz, Md Kamrul Hassan, Abdul Hanif, Abdur Rahed Khan, and Muhammad Saiful Islam. "Effect of Preoperative Chemotherapy in the Treatment of Advanced Wilms Tumor." Journal of Paediatric Surgeons of Bangladesh 3, no. 2 (2015): 56–60. http://dx.doi.org/10.3329/jpsb.v3i2.23913.

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Introduction: The management of Wilms tumor still remains a matter of great challenge to pediatric surgeons and also to pediatric oncologists. The tumor continues to be the subject of intensive investigations that with the aid of co-operative protocols by the National Wilms Tumor Study (NWTS) have resulted in marked improvement in survival. Surgical excision remains the cornerstone of treatment of Wilms tumor; however the dramatic improvement in overall survival is the result of coordinated use of surgery, chemotherapy and radiation therapy.Materials and methods: This was a prospective stud

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