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Dissertations / Theses on the topic 'Adverse effects'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Ferreira, Alexandre. "Efeitos da exposição a baixas doses de hidroquinona e fenol sobre a mobilização e função leucocitária." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-06122017-115713/.

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Os efeitos tóxicos decorrentes da exposição ambiental e ocupacional ao benzeno são amplamente descritos na literatura. Seus produtos de biotransformação fenólicos, entre os quais os compostos hidroxilados como FE e hidroquinona HQ, são indutores importantes de efeitos citotóxicos e genotóxicos responsáveis pela toxicidade ao sistema imune. No entanto, a contribuição de cada metabólito e os mecanismos envolvidos não estão completamente esclarecidos. Desta forma, o presente trabalho teve por objetivo estudar a capacidade da resposta inflamatória em ratos expostos à HQ, ao FE, ou a ambos simultan

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2

Lau, Phyllis Min-yu. "Adverse drug reactions in oncology." Monash University, Dept. of Pharmacy Practice, 2003. http://arrow.monash.edu.au/hdl/1959.1/5549.

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3

Ödmark, Inga-Stina. "Hormone replacement therapy : benefits and adverse effects." Doctoral thesis, Umeå universitet, Obstetrik och gynekologi, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-243.

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Background: Numerous studies have shown that estrogen replacement therapy (ERT) is an effective treatment for vasomotor symptoms, insomnia and vaginal dryness. Beneficial effects have also been shown on lipid patterns and on the incidence of osteoporotic fractures. As ERT increases the risk of endometrial adenocarcinoma, combinations with various progestogens have been developed in order to protect the endometrium. However, the addition of progestogens tends to reduce the beneficial effects of estrogens on mood, cognition and lipid metabolism. The added progestogen often causes side effects su

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4

Ödmark, Inga-Stina. "Hormone replacement therapy : benefits and adverse effects /." Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-243.

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5

Ibrahim, Yusuf Hassan, and Jibril Mohamed Abdullahi. "Adverse effects of khat on somali families." Thesis, Högskolan i Gävle, Avdelningen för socialt arbete och psykologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-11912.

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6

Crawford, Andrew Alexander. "Genetic predictors of adverse effects of antidepressants." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.686641.

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Antidepressant-induced adverse effects are common, occur early on in treatment and affect adherence. This thesis aims to gain a greater understanding of genetic markers involved in antidepressant-induced adverse effects. This will include: (i) clarifying the role of the most widely studied polymorphism in this area, the serotonin transporter linked polymorphic region (5-HTTLPR), on discontinuation from antidepressant treatment; (ii) improving our understanding of the adverse effects induced by two pharmacologically different antidepressants; and (iii) examining whether genetic markers can be u

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7

Liao, Haihong. "Tissue responses to bone-implant biomaterials /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3564-5/.

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8

Haag, Grönlund Marie. "Liver tumour promoting effects by polychlorinated biphenyls /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3203-4/.

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9

Fryer, Kirsty Laura. "Adverse effects of antidepressants in central white matter." Thesis, University of Nottingham, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.717072.

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Major depressive disorder (depression) is a significant, recurrent disorder, affecting over 350 million people worldwide. Often having a detrimental effect on quality of life, daily functioning, medical morbidity, and mortality it is one of the leading causes of disability worldwide. Depression pathology is little understood, and so treatments are often a 'stab in the dark'. Currently the most widely prescribed pharmacological treatment for depression is a group of antidepressants named the SSRIs (Selective Serotonin Reuptake Inhibitors), however their effectiveness over placebo is hotly debat

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10

Gaskill, Cynthia L. "Adverse effects of phenobarbital therapy in epileptic dogs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2002. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63254.pdf.

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11

Fridriksson, Jon Örn. "Adverse effects of curative treatment of prostate cancer." Doctoral thesis, Umeå universitet, Urologi och andrologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-128709.

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Background Screening for prostate cancer is debated, there is conflicting data on the net benefit of screening. Men who consider screening need to be informed on the pros and cons. Rehospitalization after surgery can be used as an indicator of general quality of care. For radical prostatectomy, little is known on the readmission rate after surgery. Men diagnosed with low- and intermediate-risk prostate cancer have low prostate-cancer specific mortality. However, adverse effects after curative treatment can be severe and decrease quality of life. Curative treatments for prostate cancer differ m

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12

Gunter, Bryan R., Kristen A. Butler, Richard L. Wallace, et al. "NSAIDs-induced Cardiovascular Adverse Effects: A Meta-analysis." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/95.

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13

Legge, Sophie E. "Examining treatment response and adverse effects of clozapine." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/91366/.

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The antipsychotic clozapine is uniquely effective in the management of treatmentresistant schizophrenia (TRS), but its use is limited by its potential to induce agranulocytosis. A substantial proportion of patients discontinue clozapine treatment, which carries a poor prognosis, and only 30-60% of patients with TRS will respond to clozapine. The causes of clozapine-associated agranulocytosis, and of its precursor neutropenia, are largely unknown although genetic factors contribute. To examine the genetic susceptibility to clozapine-associated neutropenia, I conducted a multifaceted genetic ana

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14

Warui, Edward Ndungu. "Adverse effects of Kikuyu traditions to Christian marriages." Berlin Viademica-Verl, 2009. http://d-nb.info/997338946/04.

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15

Almeida, Nisha. "Measures of maternal tobacco smoke exposure and foetal growth." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112375.

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Objective. Most biomarker studies of maternal smoking have been based on a single blood or urinary cotinine value, which is inadequate in capturing maternal tobacco exposure over the entire pregnancy. This thesis used maternal hair biomarkers to investigate the association between maternal active and passive smoking, and birthweight for gestational age (BW for GA).<br>Methods. Subjects were 444 term controls drawn from 5,337 participants of a multi-centre nested case-control study of preterm birth in Montreal. Maternal hair, collected after delivery, was measured for average nicotine and cotin

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16

Loftenius, Annika. "Effects of mercury and fluoride on human immune cells : elucidation of mechanisms /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3304-9/.

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17

Barros, Ana Raquel Gonçalves de. "Marcadores biológicos de tabagismo : determinação de cutoff points." Master's thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2011. http://hdl.handle.net/10362/5914.

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VII - CONSIDERAÇÕES FINAIS Este estudo desenvolveu-se devido facto de tanto quanto nos é dado a conhecer não terem sido determinados cutoff points de diferenciação entre fumadores e não fumadores em Portugal. Segundo vários autores é importante que estes valores sejam determinados em cada país devido às suas particularidades de prevalência do tabagismo e exposição involuntária ao fumo do tabaco. Foram também estudadas as variáveis que estão associadas e que influenciam os níveis do COex, da COHb, da cotinina plasmática e da cotinina urinária. De forma a cumprir os objectivos definidos,

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18

Hyzy, Sharon Leigh. "Adverse effects of bone morphogenic protein-2 during osseointegration." Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44728.

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Modifications of biomaterial surface properties are employed to increase osteoblast differentiation and bone formation. Microtextured metallic surfaces promote osteoblast differentiation and high surface energy- achieved by controlling surface hydrocarbon contamination- increases osteoblast differentiation and peri-implant bone formation. Recombinant human bone morphogenic protein 2 (BMP2) is approved to induce bone formation in a number of applications. It is used clinically in combination with biomaterials to improve peri-implant bone formation and osseointegration. The amount of BMP2 that i

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19

Hickson, Michelle Jaqueline. "Possible adverse effects of fungus-feeding nematodes on seedlings." Thesis, University of Leeds, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305372.

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20

Coton, Sonia Jayne. "Pregestational diabetes mellitus during pregnancy and its adverse effects." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10061772/.

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Background: In 1989 the Saint Vincent declaration set out to reduce the risk for pregnant women with diabetes to those without diabetes. A number of studies, since the declaration found that foetal and neonatal adverse pregnancy outcomes in women with type 1 diabetes remained increased. Literature for women with type 2 diabetes and maternal complications is limited. My aim is to assess whether women with type 1 and 2 diabetes remain at increased risk of pregnancy complications. Methods: Using a primary care database; THIN, I investigated the prevalence of: pregestational diabetes in pregnancy

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21

Jain, Kamini. "Prevention of treatment related adverse effects in cystic fibrosis." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/55105/.

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Cystic fibrosis (CF) is one of the commonest life-limiting genetic disorders in the Caucasian population. Management involves frequent administration of antibiotics including aminoglycosides. With improving survival, it is time to focus on various age-related and treatment-associated adverse influences. The objective of this research was to evaluate renal function in CF, determine the effects of cumulative antibiotic exposure and to identify ways to reduce associated comorbidity. A cross-sectional study showed that a small number of adults and children with CF had low glomerular filtration rat

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22

Hillert, Lena. "Hypersensitivity to electricity : symptoms, risk factors and therapeutic interventions /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-016-4/.

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23

Sundberg, Kathrin. "Carcinogenic polycyclic aromatic hydrocarbons : role of human glutathione transferases in conjugate formation and DNA protection /." Stockholm : [Karolinska Univ. Press], 2001. http://diss.kib.ki.se/2001/91-7349-046-6/.

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24

Thiblin, Ingemar. "Anabolic androgenic steroids and violence : a medicolegal and experimental study /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3495-9/.

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25

Gunnarsson, Iva. "SLE : pathogenetic mechanisms in nephritis and sulphasalazine-induced lupus reactions /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3654-4/.

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26

Hildebrand, Bengt E. "Neurobiological basis of the nicotine withdrawal reaction : an experimental analysis /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3874-1/.

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27

Melkersson, Kristina. "Influence of antipsychotic drugs on hormone levels /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4089-4/.

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28

Lagarde, Frédéric. "Residential radon exposure and lung cancer : risk assessment based on epidemiologic data /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4282-x/.

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29

Eriksson, Tove L. J. "Dust mite allergens : cloning, characterisation and T-cell responses /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4645-0/.

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30

Bin, Ashoor Al Mahri Ghalia Ghazi Abdulla. "Maternal thyroid function and its effects on adverse pregnancy outcome." Thesis, King's College London (University of London), 2013. http://kclpure.kcl.ac.uk/portal/en/theses/maternal-thyroid-function-and-its-effects-on-adverse-pregnancy-outcome(3c8114e1-ed98-4773-8340-10cf5b54c096).html.

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The aims of this thesis are firstly, to establish reference ranges of serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thryroxin (FT4) at 11-13 weeks’ gestation in singleton and twin pregnancies and to examine the effect of maternal characteristics and serum antithyroid antibodies and free ß-hCG on the levels of TSH, FT3 and FT4, and secondly to investigate the possible association between maternal thyroid dysfunction in pregnancies complicated by fetal death, preeclampsia (PE), delivery of small for gestational age (SGA) neonates, preterm delivery and fetal aneupl

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31

Mulinge, Florence Muthoni. "Identifying, recording and monitoring adverse effects associated with antriretroviral treatment." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1491.

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South Africa, with an estimated 5.7 million people living with HIV, continues to have one of the largest epidemics in the world. The introduction of HAART resulted in prolonged and improved quality of life of many infected patients. However, adverse effects caused by these drugs have become a major concern as they affect the adherence of patients and in some cases even result in the death of patients. Although much research has been and is still being conducted in the area of understanding, preventing and management of ARV adverse effects, there is still a need for patients to be actively invo

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32

Loeb, Jeffrey Thomas. "Regulatory mitigation of the adverse environmental effects of urban blasting." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42948.

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Blasting techniques and protective measures exist that can mitigate risks associated with flyrock and the nuisance of vibration, and overpressure. However, these are often misused or not used because there are no prescriptive regulatory requirements and typically, urban blasting guidelines do not exist. The relationship between the increasingly negative publicity that the urban blasting industry receives and the existing state of regulatory control on blasting in urban environments is presented. Specific research points include: 1. Incidents of flyrock, vibration and overpressure related to bl

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33

Nguyen, Vu Xuan 1957. "Drug surveillance system for type B adverse effects: a vision." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22865.

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Since type B adverse drug reactions tend to be rare and serious, they tend to be treated by tertiary-care specialists; and since they are commonly iatrogenic, the specialists should be concerned to document carefully not only the case per se but also the drug use history, leading to practice data of good research quality. The specialist should also be concerned to submit the data record to a central facility that would supply the probabilities, evidence-based, that a recent drug use by a patient caused the adverse event. Continual and systematic accumulation of these data records at the centra

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34

Hayward, Giles Mortimer. "Investigating the adverse effects of novel tumour-specific IAP antagonists." Thesis, University of Leicester, 2017. http://hdl.handle.net/2381/40314.

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Inhibitor of apoptosis (IAP) proteins are negatively regulated by the mitochondrial pro-apoptotic protein, SMAC, through a tetrapeptide binding-motif. A class of drugs mimicking this motif have been developed as anti-cancer agents and have further highlighted IAP signalling in regulation of cell death. These SMAC mimetics (SMs) activate the non-canonical NF-κB pathway, induce TNFα secretion and selectively promote cell death in tumour cells; an effect potentiated in a TNFα-rich microenvironment. However, due to this mechanism of action, SMs have the potential to induce toxicity in non-tumour c

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35

Wadham, John Jeremy Beresford. "Recognition and reduction of adverse effects in research on rodents." Thesis, University of Birmingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582612.

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Routine husbandry systems and standard experimental techniques were assessed to investigate if they were stressful for laboratory rats. They were then compared with alternative methods which had been putatively "refined" to cause less suffering. It was found that rats provided with various environmental improvements were less anxious than rats housed in standard conditions and so a recommendation is made that rats be provided with nesting material whenever possible. Rats undergoing surgery were found to recover quicker if kept as near as possible to homeostasis through careful choice of peri-o

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36

Mentzel, Tammy K. "Effects of Adverse Childhood Experiences (ACEs) on Control of Diabetes." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447690892.

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37

Wang, Yu-Chin Lily. "Postmarketing surveillance of sumatriptan : patient population, efficacy, and adverse effects." Scholarly Commons, 1994. https://scholarlycommons.pacific.edu/uop_etds/2273.

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A postmarketing surveillance survey of sumatriptan use comprised 32 questions including patient demographics, headache history, and sumatriptan experience. One hundred and forty-one questionnaires were sent out, and 109 patients responded; a total of 108 patients were included in the data analysis. When compared with the national migraine population, on a percentage basis, significantly more African-Americans, females, young patients (less 45 years of age), and patients with higher mean incomes (>$45,000) were found in the present study of those taking sumatriptan (p Males (N=8) and females (N

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38

Rodgers, Amie D. Rusyn Ivan. "Modeling adverse liver effects of drugs using kNN QSAR method." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2463.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Sep. 3, 2009). "... in partial fulfillment of the requirements for the degree of Masters of Sciences in the School of Medicine Toxicology." Discipline: Toxicology; Department/School: Medicine.

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39

Nihlén, Annsofi. "Ethers as gasoline additives : toxicokinetics and acute effects in humans /." Solna : National Institute for Working Life (Arbetslivsinstitutet), 1998. http://diss.kib.ki.se/1999/91-7045-504-X/.

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40

Booth, Alexis, Jill D. Stinson, and Carrie C. LeMay. "Effects of Adverse Childhood Experiences on High-Risk Inpatients’ Criminal Behavior." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/7960.

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Adverse childhood experiences (ACEs) play a role in the development of chronic mental and physical diseases in adulthood. These experiences include adversities such as: emotional/verbal abuse, sexual abuse, physical abuse, and household dysfunction. Building from the ACE study conducted by Kaiser Permanente from 1995-1997, this study aims to contribute to the body of knowledge gained about ACE’s and their effects on health in high risk populations, and to examine the effects of developmental diversity on criminality. In this study, we hypothesize that forensic mental health offenders will have

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41

Golder, Su. "Evaluating and optimising the retrieval of research evidence for systematic reviews of adverse drug effects and adverse drug reactions." Thesis, University of York, 2013. http://etheses.whiterose.ac.uk/4749/.

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Systematic reviews can provide timely, reliable evidence on which to make informed decisions. In order to make balanced decisions, information is not only needed on the benefits of an intervention, but also on its adverse effects. Yet few systematic reviews incorporate adverse effects data in their analysis. There is currently a lack of guidance on how to identify adverse effects data, this may impede systematic reviewers. This thesis helps address this situation by evaluating and optimising the methods for retrieval of research evidence for systematic reviews of adverse effects. The first sta

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42

Nikolaidis, Theoklis. "Water ingestion effects on gas turbine engine performance." Thesis, Cranfield University, 2008. http://hdl.handle.net/1826/3516.

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Although gas turbine engines are designed to use dry air as the working fluid, the great demand over the last decades for air travel at several altitudes and speeds has increased aircraft’s exposure to inclement weather conditions. Although, they are required to perform safely under the effect of various meteorological phenomena, in which air entering the engine contains water, several incidents have been reported to the aviation authorities about power loss during flight at inclement weather. It was understood that the rain ingestion into a gas turbine engine influences the performance of the

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43

Pascoe, John M., David L. Wood, James H. Duffee, and Alice Kuo. "Mediators and Adverse Effects of Child Poverty in the United States." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/5137.

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The link between poverty and children’s health is well recognized. Even temporary poverty may have an adverse effect on children’s health, and data consistently support the observation that poverty in childhood continues to have a negative effect on health into adulthood. In addition to childhood morbidity being related to child poverty, epidemiologic studies have documented a mortality gradient for children aged 1 to 15 years (and adults), with poor children experiencing a higher mortality rate than children from higher-income families. The global great recession is only now very slowly abati

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44

Lafrance, Jean-Philippe. "Determinants of vascular access-related bloodstream infections among patients receiving hemodialysis." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111949.

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Vascular access-related bloodstream infection (BSI) is frequent among patients undergoing hemodialysis increasing significantly their morbidity and mortality. Studies assessing centre- and patient-predictors of BSI have had inadequate sample size and follow-up time. The aims of this project are: to describe the incidence rates; and to determine patient- and centre-level predictors of BSI in a cohort of incident hemodialysis patients treated in teaching or community hospitals, and in First Nation dialysis units. The rates of BSI in our population were lower than those observed in other settings

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45

Wondimu, Biniyam. "Cyclosporin A-induced gingival overgrowth in renal transplant patients : a clinical, histological and experimental study /." Stockholm, 1997. http://diss.kib.ki.se/1997/99-2486642-8.

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46

Damasceno, Maria Cecilia de Toledo. "Prevenção do remodelamento ventricular esquerdo induzido pelo decanoato de nandrolona." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/5/5159/tde-19012007-172029/.

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Os esteróides anabólico-androgênicos (EAA) são derivados da testosterona que foram desenvolvidos para o tratamento de determinadas condições médicas. Hoje as utilizações feitas por atletas com objetivo de melhorar o desempenho esportivo e por não atletas interessados em melhorar a força física e a aparência vem chamando mais a atenção. O aparecimento do remodelamento ventricular está associado ao uso de EAA. Neste estudo, caracterizamos o remodelamento ventricular que ocorre com o uso de um EAA e avaliamos sua relação com a administração concomitante de um IECA. Os achados mostram que os EAA c

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47

Westberg, Håkan. "Chemical exposures, biological monitoring and cancer risks in Swedish aluminium foundries and remelting plants /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med696s.pdf.

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48

Bogdanovic, Gordana. "Studies on human polyomavirus infection in association with central nervous system disorders and bone marrow transplantation /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980612bogd.

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49

Joseph, Emlyn Clive. "Pathogenesis of arteriopathy induced by PDE III inhibitors in the rat and dog." Thesis, Queen Mary, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307684.

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50

Kerr, Daniel Paul. "The use of acupuncture in physiotherapy practice and its efficacy in the management of low back pain." Thesis, University of Ulster, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342533.

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