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Journal articles on the topic 'Adverse reaction to medications'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Bibave, Kiran H. Tambe Ayush K.* Gangarde Atharv S. Vyavahare Sakshi S. Bandal Vaishnavi P. Dhas Sushma S. "Adverse Drug Reaction Reported To Injection Calcium Gluconate." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 828–36. https://doi.org/10.5281/zenodo.10853399.

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In the modern day, adverse drug reactions (ADR) are one of the most important subjects to evaluate. The World Health Organization (WHO) defines an adverse drug reaction (ADR) as any unpleasant and inadvertent reaction to a drug that happens at dosages used in humans for disease prophylaxis, diagnosis, or therapy; or for altering physiological function. This definition intentionally leaves out therapeutic failures, overdoses, drug abuse, noncompliance, and medication errors.  Furthermore, it has been considered a noteworthy adverse event that arises from a medical product-related intervent

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Eghbali-Zarch, Maryam, Reza Tavakkoli-Moghaddam, Fatemeh Esfahanian, Amir Azaron, and Mohammad Mehdi Sepehri. "A Markov decision process for modeling adverse drug reactions in medication treatment of type 2 diabetes." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 233, no. 8 (2019): 793–811. http://dx.doi.org/10.1177/0954411919853394.

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Type 2 diabetes has an increasing prevalence and high cost of treatment. The goal of type 2 diabetes treatment is to control patients’ blood glucose level by pharmacological interventions and to prevent adverse disease-related complications. Therefore, it is important to optimize the medication treatment plans for type 2 diabetes patients to enhance the quality of their lives and to decrease the economic burden of this chronic disease. Since the treatment of type 2 diabetes relies on medication, it is vital to consider adverse drug reactions. Adverse drug reaction is undesired harmful reaction

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Kandolf-Sekulović, Lidija, and Tatjana Radević. "Cutaneous Adverse Drug Reactions / Dematološka neželjena dejstva lekova." Serbian Journal of Dermatology and Venerology 4, no. 2 (2012): 61–76. http://dx.doi.org/10.2478/v10249-012-0005-8.

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Abstract Adverse drug reactions may be defined as undesirable clinical manifestations resulting from administration of a particular drug; this includes reactions due to overdose, predictable side effects, and unanticipated adverse manifestations. Adverse drug effects on the skin are among the most frequent reactions and, according to a study, account for approximately 14% of all adverse drug reactions. However, the incidence of cutaneous adverse effects in general population is unknown. Systemic drug administration results in various cutaneous adverse reactions, and medications used in the tre

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danjuma, mohammed, Bhagya Sree, Unwam Jumbo, et al. "Outcome of COVID-19 Positive Patients with type 2 Diabetes and Polypharmacy: an Examination of a Tertiary Hospital Cohort." Yemen Journal of Medicine 4, no. 1 (2025): 117–22. https://doi.org/10.63475/yjm.v4i1.0051.

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Background: COVID-19-positive patients are at increased risk of adverse clinical outcomes, with type 2 diabetes cohorts at substantially higher risk compared to the general population. The additional role of diabetic and non-diabetic polypharmacy in these patients' clinical course has remained unexamined. In this study we have comprehensively examined the role of polypharmacy in the determination of mortality outcomes in patients with COVID-19 clinical syndrome. Methods: We retrospectively examined case notes and electronic records of N = 497 patients with type 2 diabetes and COVID-19 infectio

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Speicher, Leigh, Sheena Crosby, and Michael J. Schuh. "Pharmacogenomics Testing Confirmation of Carbamazepine Induced DRESS Reaction of an HLA-A*31:01 Positive, Polypharmacy Patient." INNOVATIONS in pharmacy 12, no. 4 (2021): 20. http://dx.doi.org/10.24926/iip.v12i4.4341.

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Pharmacogenomics (PGx) melds well with polypharmacy as another tool to identify medication related problems (MRPs) more specifically so they may be solved most effectively. PGx can pre-emptively assist in medication selection, medication dosing or identify better medications for patients already taking a medication. PGx can also confirm suspect medications of causing MRPs such as adverse drug reactions (ADRs) or drug interactions. In this case, PGx testing confirmed presence of a serious human leukocyte antigen (HLA) drug reaction with eosinophilia and systemic symptoms (DRESS) after a suspect

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Yogita D. Pol, Yogita D. Pol, Omkar A. Devade Omkar A. Devade, Prathamesh Narale Prathamesh Narale, Sahil S. Gole Sahil S.Gole, and Dipali Sirsam Dipali Sirsam. "A Review on Adverse Drug Reaction." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 566–72. https://doi.org/10.35629/4494-1003566572.

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Adverse Drug Reactions (ADRs) are unintended and harmful responses to medications that occur at normal therapeutic doses. They represent a significant challenge in clinical practice, contributing to increased morbidity, prolonged hospital stays, and additional healthcare costs. ADRs can range from mild allergic reactions to severe, life-threatening conditions, and they are a leading cause of patient safety concerns worldwide. Effective detection, monitoring, and reporting systems—such as pharmacovigilance—are essential for minimizing risks associated with drug therapy. This abstract highlights

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Gomes, Daniel, Maria Teresa Herdeiro, Inês Ribeiro-Vaz, Pedro Lopes Ferreira, and Fátima Roque. "Adverse Drug Reactions and Potentially Inappropriate Medication in Older Patients: Analysis of the Portuguese Pharmacovigilance Database." Journal of Clinical Medicine 11, no. 8 (2022): 2229. http://dx.doi.org/10.3390/jcm11082229.

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Criteria have been developed to identify potentially inappropriate medications that can enhance adverse reactions, highly prevalent in older patient’s therapy. This study aimed to identify potentially inappropriate medications within the adverse drug reactions reported in the Portuguese pharmacovigilance system, characterizing the reports where inappropriate medications were identified. INFARMED, I.P. provided all adverse drug reactions reported from January to December 2019 in 65-year-old and older patients. Adverse drug reactions were characterized according to the System Organs Classes, ser

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Shrivastava, Pranjul, and Syed Sajid Ali Syed Sabir Ali. "Assessing the effectiveness of state-level pharmacy laws on opioid prescribing practices." Journal of Neonatal Surgery 14, no. 1S (2025): 323–28. https://doi.org/10.52783/jns.v14.1540.

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Despite their positive impacts on health, medications can have negative side effects because of adverse drug reactions (ADRs). Physicians, pharmacists, and nursing staff have a duty to use caution while prescribing medication. Patients are becoming more conscious of drug-related issues in today's consumer-driven world, and they want to be included in the decision-making process for many elements of their prescription and health care. This study concludes that polypharmacy, a history of bad drug responses, and coexisting illnesses are independent predictors of adverse drug reactions. Elderly pe

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Ashish, kumar* Abhishek Shrivastava Dr. Jitendra Banweer. "Adverse Drug Reaction Monitoring." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1996–2001. https://doi.org/10.5281/zenodo.15389007.

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Adverse drug reactions (ADRs) are unintended and harmful effects of medications that pose a significant threat to patient safety. Monitoring and reporting these reactions is a critical component of pharmacovigilance, aiming to ensure safe and effective drug use. This article highlights the importance of ADR monitoring, outlines the systems and methods used globally and in India, and discusses the need for increased awareness and collaboration among healthcare professionals. Strengthening ADR monitoring can reduce drug-related risks, improve therapeutic outcomes, and enhance public health.

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Truong, Mimi, Wubshet Tesfaye, Kamal Sud, et al. "Drug-Related Problems and Sick Day Management Considerations for Medications that Contribute to the Risk of Acute Kidney Injury." Journal of Clinical Medicine 13, no. 2 (2024): 343. http://dx.doi.org/10.3390/jcm13020343.

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Background: Medication use during acute illness increases the risk of experiencing drug related problems (DRPs), including acute kidney injuries. It is recommended that potentially nephrotoxic medications are withheld during acute illness, including sulfonylureas, angiotensin converting enzyme inhibitors, diuretics, metformin, angiotensin receptor blockers, non-steroidal anti-inflammatories and sodium glucose co-transporter 2 inhibitors (SADMANS). It is unknown if Australian pharmacists currently provide sick day medication management advice regarding SADMANS medications. Hence, we aimed to id

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Castanier-Dávila, María Camila. "Adverse drug reaction in a patient with autoimmune disease: Case report." Revista Alergia México 72, no. 2 (2025): 136–41. https://doi.org/10.29262/ram.v72i2.1446.

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Background: Adverse drug reactions are harmful and unintentional events related to medication use. Stevens-Johnson Syndrome is a serious adverse drug reaction that can progress to toxic epidermal necrolysis and is related to certain medications. It can even be triggered by infections and genetic factors. Case report: A 62-year-old female patient with high blood pressure developed severe skin lesions after self-medicating with paracetamol and ibuprofen. She recovered favorably after several treatments and admissions to the Intensive Care Unit. Conclusions: It is important to promptly identify t

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Carlini, Elisaldo Luiz de Araújo, and Solange Aparecida Nappo. "The pharmacovigilance of psychoactive medications in Brazil." Revista Brasileira de Psiquiatria 25, no. 4 (2003): 200–205. http://dx.doi.org/10.1590/s1516-44462003000400004.

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OBJETIVE: The present study aimed to analyze 219 notifications of suspected adverse reactions (AR) produced by psychoactive medicaments (ARPM), notified by Brazilian psychiatrists, during a 3-month period (April 1999 up to September 2001). METHOD: A notifying card for adverse reactions possibly produced by psychoactive medications was quarterly sent to all psychiatrists affiliated to the Brazilian Association of Psychiatry. Once each notification, dully filled in, was received, the possible adverse reaction was analyzed in order to verify the causality RESULTS: The psychiatrists classified as

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Poirier, Alanna M., Paul Nachowicz, and Subhasis Misra. "The role of electronic records in reporting adverse drug reactions." Journal of Clinical Oncology 30, no. 34_suppl (2012): 309. http://dx.doi.org/10.1200/jco.2012.30.34_suppl.309.

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309 Background: The Pharmacy and Therapeutics committee at a regional cancer center is responsible to report and trend existing adverse drug reactions. The electronic health record did not have an option to document the history of an event or have an alert function if a medication was re-ordered. The frequency of documented adverse drug reactions did not correlate to what was being observed on the units with the use of a paper document. Methods: InAugust 2010 a Lean Six Sigma project was initiated to improve adverse drug reaction reporting. An adverse drug reaction document along with standard

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E., Blessing, Anthony E., Uduakobong U., Anietie U., and Ndueso U. "Machine Learning Model for Adverse Drug Reaction Detection Based on Naive Bayes and XGBoost Algorithm." British Journal of Computer, Networking and Information Technology 7, no. 2 (2024): 97–114. http://dx.doi.org/10.52589/bjcnit-35mffbc6.

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Adverse drug effects, commonly referred to as adverse drug reactions (ADRs), represent undesirable and unintended responses to medications or pharmaceutical products when used at recommended doses for therapeutic purposes. These effects can range from mild, tolerable symptoms to severe, life-threatening conditions and can manifest in various ways, affecting different organ systems within the human body. ADE analysis plays a pivotal role in prioritizing patient safety. By meticulously examining the relationship between drug administration and patient responses, healthcare providers can tailor m

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Wattanapisit, Apichai, Penpun Lertwatanachai, Thittita Pongsawat, Sanhapan Wattanapisit, and Jaruporn Thongruch. "Side Effects of Antihypertensives Induced by Switching to Different Generic Medications: Case Reports." Prague Medical Report 124, no. 2 (2023): 172–76. http://dx.doi.org/10.14712/23362936.2023.13.

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Generic medication is a product that contains the same active substance and pharmaceutical characteristics as brand-name medications. Generic medications are cost-effective and comparable to brand-name medications in terms of clinical endpoints. However, the use of generic medications instead of brand-name medications is a debatable issue among patients and healthcare providers. Two patients with essential hypertension experienced side effects after switching to different generic antihypertensives (one generic medication to another generic medication). Adverse drug reactions, including, hypers

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Ostrovska, H. Yu, A. H. Sydorenko, S. Yu Chechotina, R. V. Lutsenko, and T. A. Petrova. "ADVERS DRUG REACTION: DENTAL ASPECTS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 25, no. 2 (2025): 278–82. https://doi.org/10.31718/2077-1096.25.2.278.

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Relevance. An adverse drug reaction is a complex phenomenon that may manifest as a drug-induced syndrome or as part of a broader iatrogenic condition. The use of medicinal substances dates back to the earliest stages of human civilization, and negative effects of certain treatments have long been observed by both patients and healers. In modern medicine, pharmacotherapy has reached an unprecedented level of use, which in turn has led to a growing number of adverse reactions, particularly in patients with comorbid conditions. The type and quantity of medications prescribed by dental doctors and

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Hardini, Dinda Kusuma, Silvia Wahyu Widiarti, and Saur Lumongga. "ANALISIS KUANTITATIF DAN KUALITATIF EFEK SAMPING OBAT DI RS JANTUNG DAN PEMBULUH DARAH HARAPAN KITA PERIODE JANUARI – JUNI 2021." Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan 7, no. 2 (2021): 230–35. https://doi.org/10.51352/jim.v7i2.503.

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Adverse drug reactions are undesirable effects that can be harmful or detrimental after medication administration when dosage and way of administration are in accordance with the purpose of treatment. Identification of the most common type of adverse drug reaction in Rumah Sakit Jantung dan Pembuluh Darah Harapan Kita (RSJPDHK) was executed through Adverse Drug Reactions Monitoring from January to June 2021. The aim of this study is to obtain real data on adverse drug reactions for the purpose of educating medical colleagues in order to reduce similar adverse drug reactions. The designs of thi

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Ayub, Hina, Muhammad Aslam Solangi, and Mudassar Iqbal Arain. "Analysis of Adverse Drug Reactions in Patients with Diabetes Mellitus at Private clinics in Hyderabad, Pakistan." Pakistan Journal of Medical and Health Sciences 17, no. 1 (2023): 280–82. http://dx.doi.org/10.53350/pjmhs2023171280.

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Background: Diabetes is characterized by hyperglycemia, a metabolic disorder resulting from defects in insulin secretion, action, or both. The traditional treatment choices available for diabetes include medications that are oral hypoglycemic agents and insulin. Due to the introduction of several medications during the past 20 years, the identification of adverse drug reactions has gained importance. Aim: The aim of this study was to evaluate the adverse drug reactions among diabetic patients and patients’ variables that were linked to the adverse drug reactions. Study Design: Cross-sectional

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Mir, Mashooq Ahmad, Mohd Altaf Dar, Afshana Qadir, Zulfkar Qadrie, and Humaira Ashraf. "Adverse Drug Reaction Monitoring and Assessment in Clinical Settings." Journal of Community Pharmacy Practice, no. 23 (May 28, 2022): 7–17. http://dx.doi.org/10.55529/jcpp.23.7.17.

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Implementing a structured Adverse Drug Reaction monitoring program is an effective method to proactively identify ADRs, hence enhancing the standard of patient care. The evaluation and monitoring of the safety of medications in clinical use are crucial for mitigating harm to patients and enhancing public health. In a clinical setting, this means establishing a highly structured Pharmacovigilance system. Pharmacovigilance is a crucial practice for monitoring drug-related concerns that arise after a medicine has been marketed and used in real-world settings. Pharmacovigilance and all matters con

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Khammissa, R. A. G., R. Chandran, A. Masilana, J. Lemmer, and L. Feller. "Adverse Immunologically Mediated Oral Mucosal Reactions to Systemic Medication: Lichenoid Tissue Reaction/Interface Dermatitis-Stomatitis, Autoimmune Vesiculobullous Disease, and IgE-Dependent and Immune Complex Reactions." Journal of Immunology Research 2018 (June 10, 2018): 1–10. http://dx.doi.org/10.1155/2018/7645465.

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Drug-induced hypersensitivity immune reactions are exaggerated immunoinflammatory responses to allergenic components of the medications that occur in genetically susceptible subjects. The type of hypersensitivity immune response generated, whether antibody mediated or T cell mediated, or an immune complex reaction is determined by multiple factors, including the molecular characteristics of the allergen, the route of administration of the medication, the manner of presentation of the allergen by antigen-presenting cells to naïve T cells, the repertoire of the T cell receptors, and the cytokine

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C, Shinu, Masouda TK, and Jusaina . "Effect of Polypharmacy on Adverse Drug Reaction Among Geriatric Patients at Tertiary Care Hospital." International Journal of Science and Healthcare Research 8, no. 1 (2023): 317–22. http://dx.doi.org/10.52403/ijshr.20230144.

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BACKGROUND: Polypharmacy and Drug -related problems (DRPs) have been shown to prevail in hospitalized patients. We evaluated the prevalence of polypharmacy and investigated relationship between polypharmacy and adverse drug reaction occur with it. The present study was designed to identify the adverse drug reactions occur due to polypharmacy. METHODOLOGY: This observational study was conducted for 6 months in the various department of a tertiary care Super speciality Hospital at Malabar region of Kerala. The patients were selected based on inclusion and exclusion criteria. RESULTS: A total of

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Kroshinsky, Daniela. "Adverse cutaneous reactions to medications." Clinics in Dermatology 38, no. 6 (2020): 605–6. http://dx.doi.org/10.1016/j.clindermatol.2020.06.017.

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Sternberg, Timothy L., and Nancy E. Cross. "Adverse Reactions to Nonindicated Medications." Anesthesiology 86, no. 5 (1997): 1212. http://dx.doi.org/10.1097/00000542-199705000-00026.

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Rharbaoui, H., M. Boubekri, and A. Ouanass. "Psychotropic Drugs and Liver Disorders: A Case Report." Scholars Journal of Medical Case Reports 13, no. 06 (2025): 1360–64. https://doi.org/10.36347/sjmcr.2025.v13i06.014.

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Introduction: The World Health Organization (WHO) defines an adverse drug reaction (ADR) as “a noxious and unwanted reaction occurring at doses normally used in humans for the prophylaxis, diagnosis, or treatment of disease or the modification of a physiological function, or resulting from misuse of the drug or product.” This definition implies that there is a certain degree of causal relationship (attributability) between the drug intake and the occurrence of the effect. Since all medications can cause adverse drug reactions, a risk-benefit analysis is essential whenever a medication is presc

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Yadesa, Tadele Mekuriya, Freddy Eric Kitutu, Serawit Deyno, Patrick Engeu Ogwang, Robert Tamukong, and Paul E. Alele. "Prevalence, characteristics and predicting risk factors of adverse drug reactions among hospitalized older adults: A systematic review and meta-analysis." SAGE Open Medicine 9 (January 2021): 205031212110390. http://dx.doi.org/10.1177/20503121211039099.

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Background: Occurrence of adverse drug reactions is a major global health problem mostly affecting older adults. Identifying the magnitude and predictors of adverse drug reactions is crucial to developing strategies to mitigate the burden of adverse drug reactions. This study’s objectives were to estimate and compare the prevalences of adverse drug reactions, to characterize them and to identify the predictors among hospitalized older adults. Methods: A comprehensive systematic literature search including both prevalence and risk factors of adverse drug reactions in hospitalized older adults w

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Aparajita, Mohapatra, Kumar Mohanty Sujit, Kumar Nayak Niranjan, and Tripathy Ashish. "Analyzing Adverse Drug Reaction Reporting for Oncology Medications: A Retrospective Study." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 142–46. https://doi.org/10.5281/zenodo.11399047.

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<strong>Background</strong><strong>:</strong> Adverse Drug Reaction (ADR) reporting is critical in oncology due to the complex and potent nature of oncology medications, which often have a high risk of adverse effects. Accurate ADR reporting helps identify potential risks associated with oncology drugs, contributing to safer clinical practices and enhanced patient care.The aim of this study was to investigate the prevalence and patterns of adverse drug reactions (ADRs) associated with oncology drugs among patients. <strong>Methods</strong><strong>:</strong> The study included 12

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Setzer, Kayla, Nicholas Baldwin, Tracey Mersfelder, and Matthew Kelly. "Profound hypotension following concomitant administration of tizanidine and lisinopril." BMJ Case Reports 18, no. 2 (2025): e262982. https://doi.org/10.1136/bcr-2024-262982.

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Tizanidine, a muscle relaxant, exerts its mechanism as a centrally acting alpha-2 adrenergic receptor agonist and binds to imidazoline receptors. Bradycardia and hypotension are adverse effects associated with alpha-2 adrenergic receptor agonists. A man in his 50s with a medical history of hypertension and chronic back pain presented with chest pain and hypertension. Pertinent medication history included metoprolol tartrate, lisinopril, hydralazine, hydrochlorothiazide and tizanidine and was continued. Following medication administration, the patient was hypotensive. Further episodes occurred

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Madhvi, Kareliya, Kamejaliya Dinesh, and AjitaPillai. "To Study the Pattern of Drug Use and Safety of Medication Used in Liver Disease Patients at Tertiary Care Teaching Hospital." International Journal of Pharmaceutical and Clinical Research 15, no. 6 (2023): 1628–36. https://doi.org/10.5281/zenodo.12513960.

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<strong>Background:</strong> One of the most common non-communicable diseases, liver disease alters the pharmacokinetics of many medications, necessitating careful monitoring and dosing adjustments to ensure the best possible patient outcomes. <strong>Aims and Objectives:</strong> The present study was undertaken to evaluate the drug usage pattern and its safety profile in liver disease patients. <strong>Materials and Method:</strong> An observational and cross-sectional study was conducted in the department of medicine in a tertiary care teaching hospital from January

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Yoshioka, Manabu, Yu Sawada, and Motonobu Nakamura. "Diagnostic Tools and Biomarkers for Severe Drug Eruptions." International Journal of Molecular Sciences 22, no. 14 (2021): 7527. http://dx.doi.org/10.3390/ijms22147527.

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In accordance with the development of human technology, various medications have been speedily developed in the current decade. While they have beneficial impact on various diseases, these medications accidentally cause adverse reactions, especially drug eruption. This delayed hypersensitivity reaction in the skin sometimes causes a life-threatening adverse reaction, namely Stevens-Johnson syndrome and toxic epidermal necrolysis. Therefore, how to identify these clinical courses in early time points is a critical issue. To improve this problem, various biomarkers have been found for these seve

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Nooja, Moinudeen 1. Thazneem Bagum T.D 1. Dr. Manoj K. 2. *. Dr. Alfet Raju 3. Dr. L. Panayappan 4. Dr. K.Krishnakumar 5. "PREVENTABILITY ASSESSMENT OF ADVERSE DRUG REACTIONS IN PSYCHIATRY INPATIENT DEPARTMENT USING MODIFIED SCHUMOCK AND THORNTON'S SCALE." Journal of Pharma Research 8, no. 7 (2019): 497–504. https://doi.org/10.5281/zenodo.3357201.

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<strong><em>ABSTRACT</em></strong> <strong><em>Aim: </em></strong><em>To assess the preventability of Adverse Drug Reactions in a psychiatry inpatient department using Modified Schumock and Thornton’s scale. </em> <strong><em>Objectives: </em></strong><em>To monitor and report the nature of Adverse Drug Reactions in psychiatry inpatient department. To assess the preventability of documented Adverse Drug Reactions using Modified Schumock and Thornton’s scale. </em> <strong><em>Method: </em></strong><em>A prospective observational study was carried out in a psychiatry inpatient depar

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Morán-Mariños, Cristian, Felix Llanos-Tejada, Juan Salas-Lopez, Antonella Chavez-Huamani, Renato Casanova-Mendoza, and Renzo Villanueva-Villegas. "DRESS syndrome due to anti-TB drugs: A complex case with successful re-desensitization of group A drugs." Journal of Family Medicine and Primary Care 13, no. 4 (2024): 1555–58. http://dx.doi.org/10.4103/jfmpc.jfmpc_1516_23.

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ABSTRACT Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare, life-threatening adverse reaction caused by certain medications. Clinical findings usually include rash, fever, lymphadenopathy, and eosinophilia, and in some cases, they may affect major organs. This reaction caused by antituberculosis (TB) medication poses a public health risk due to treatment discontinuation, adherence, or success in cure. We present a 23-year-old female patient who developed DRESS syndrome as a result of group A anti-TB drugs (ATDs), an exceedingly rare occurrence. The patient’s medi

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Larina, V. N., T. A. Gaydina, A. S. Dvornikov, and K. E. Nazimkin. "Drug toxicoderma: possible causes, clinical manifestations and approaches to management at the outpatient’s stage." Clinical Medicine (Russian Journal) 98, no. 11-12 (2021): 745–51. http://dx.doi.org/10.30629/0023-2149-2020-98-11-12-745-751.

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Adverse cutaneous drug reactions are skin manifestations resulting from systemic drug administration. Toxicoderma under medication treatment is the most common adverse cutaneous reaction with difficulty to diagnose, especially at early stages. The development and active introduction of new drugs into practice, uncontrolled self-medication of patients, polypharmacy, and repeated contact with one and the same preparation, contribute to the growth of toxicoderma. Doctors should treat patients with toxicoderma carefully, as it can be developed at any time and have different clinical manifestations

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Sharif, Bayan Omar, Mohammed Ali Mahmood Naza Mohammed Ali Naza, Sakar Bikhtiyar Saber, Danyar Akbar Muhamad, Shanar Jamal Rahim, and Frishta Ahmed Salih. "Drug-induced Photosensitivity: Photoallergic, Phototoxic and Adverse Drug Reactions." International Journal of Medical Sciences and Nursing Research 4, no. 4 (2025): 23–28. https://doi.org/10.55349/ijmsnr.2024442328.

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<strong>Background: </strong>Drug-induced photosensitivity refers to skin reactions caused by exposure to ultraviolet light following the use of certain medications, which can be administered topically or orally. When ultraviolet radiation interacts with a chemical present in adequate concentrations within the skin, it may trigger various reactions, particularly in susceptible individuals. The most common responses are photoallergic and phototoxic reactions. <strong>Methods: </strong>In this paper, we discussed about drug-induced photosensitivity: Photoallergic, phototoxic and advers

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Yaghi, Marita, Teresa Ju, Jamie Hu, Arvin Jadoo, and Andrea Maderal. "Dupilumab-induced Acanthosis Nigricans." SKIN The Journal of Cutaneous Medicine 8, no. 2 (2024): 1413–17. http://dx.doi.org/10.25251/skin.8.2.9.

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Dupilumab is a human monoclonal IgG4 antibody to interleukin-4 (IL-4) and IL-13 approved for the treatment of moderate-to-severe atopic dermatitis (AD) in patients six months or older. Several cutaneous adverse reactions to dupilumab have been reported, including facial dermatitis and psoriasis. Herein, we present a unique case of dupilumab-induced acanthosis nigricans (AN) in a patient treated for concomitant AD and contact dermatitis, in the absence of other associated conditions or potential culprit medications. The patient had complete resolution of the lesions with discontinuation of medi

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Ocampo, José Mauricio, José Arnoby Chacón, José Fernando Gómez, Carmen Lucía Curcio, and Francisco Javier Tamayo. "Adverse drug reactions and adverse drug events in elderly patients consulting a hospital emergency unit." Colombia Medica 39, no. 2 (2008): 135–46. http://dx.doi.org/10.25100/cm.v39i2.569.

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Objective: To determine adverse drug events (ADE) and adverse drug reactions (ADR) in elderly patients consulting a third level hospital emergency unit (EU). Design: Cross sectional study. Patients and methods: Four hundred patients aged sixty years or older consulting the EU (Caldas Hospital, Manizales, Colombia) (March-May 2004). Data on demographic characteristics, primary diagnosis, associated conditions and evaluation of medications intake were taken from the clinical records. Functional state was measured according with Barthel’s index. Type and severity of ADE and ADR were categorized.

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Elendu, Chukwuka, Joseph Adenikinju, Faith Ogala, Tunde Ologunde, Samuel Adebambo, and Emmanuel Egbunu. "Metoclopramide-induced acute dystonic reaction: A pediatric case report." Medicine 102, no. 48 (2023): e36140. http://dx.doi.org/10.1097/md.0000000000036140.

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Introduction: This case report presents a unique acute dystonic reaction (ADR) induced by metoclopramide in a 6-year-old male patient with pertussis-associated vomiting. The rarity of such a reaction in pediatric patients underscores the significance of this case in contributing to the scientific literature. This report highlights the need for heightened awareness of the potential adverse effects of medications commonly used in pediatrics and emphasizes the importance of tailored interventions for this population. Main symptoms and important clinical findings: Following the administration of m

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Wallace, Carla S., and Bruce A. Mueller. "Lovastatin-Induced Rhabdomyolysis in the Absence of Concomitant Drugs." Annals of Pharmacotherapy 26, no. 2 (1992): 190–92. http://dx.doi.org/10.1177/106002809202600209.

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OBJECTIVE: Presentation of a case of lovastatin-induced rhabdomyolysis in the absence of other medications known to potentiate this adverse effect. METHODOLOGY: Case report. RESULTS: A 60-year-old black man developed rhabdomyolysis after receiving lovastatin for 14 months. Rhabdomyolysis developed in the absence of other medications previously reported to cause this adverse effect when administered concomitantly with lovastatin. Adverse drug reaction causality algorithms categorized this reaction as either possible or probable. CONCLUSIONS: Rhabdomyolysis is an uncommon adverse effect associat

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Nazarko, Linda. "Medication management: how medication review improves lives and reduces waste." British Journal of Community Nursing 29, no. 10 (2024): 480–86. http://dx.doi.org/10.12968/bjcn.2024.0102.

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Ageing is associated with an increased risk of adverse drug reactions. This calls for great care and diligent follow up when prescribing medication to older patients. Yet, this is seldom the case and the proportion of older people taking five or more medications has quadrupled from 12% to 49% in the last 20 years. Certain medications are riskier than others. Those with anticholinergic effects are of particular concern. Adverse effects of anticholinergics include dry mouth, nausea, dizziness, fatigue, vomiting, constipation, abdominal pain, urinary retention, blurred vision, tachycardia and neu

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Bhushan, Rajput* Neha Harad Dikshita Madhavi Aditya Yadav Pradnya Pophale Tejaswini Asawe. "Pharmacovigilance: Safeguarding Patients Through Drug Safety Monitoring." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1171–77. https://doi.org/10.5281/zenodo.15185821.

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Pharmacovigilance promotes the responsible and safe use of medications. Pharmacovigilance requires the spontaneous reporting of adverse drug reactions (ADRs). ADRs are, nevertheless, significantly underreported. In developing nations, adverse medication responses have grown to be a serious issue. Pharmacovigilance knowledge could serve as the foundation for initiatives meant to increase reporting rates and lower ADRs.

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Camacho-Halili, Marie, Roxanne George, Malcolm Gottesman, and Mark Davis-Lorton. "An approach to natalizumab hypersensitivity: a case series of induction of tolerance." Multiple Sclerosis Journal 17, no. 2 (2010): 250–53. http://dx.doi.org/10.1177/1352458510388966.

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Induction of tolerance protocols have been applied successfully to manage allergic reactions to many medications. Hypersensitivity reactions to natalizumab (TYSABRI®) have been recognized as a growing problem. In circumstances where a hypersensitivity reaction to a medication has occurred, but no suitable alternative exists, drug induction of tolerance protocols may be considered. Drug induction of tolerance protocols were performed in three patients with prior hypersensitivity reactions to natalizumab. All three patients tolerated the protocol without adverse reactions, allowing for the safe

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Mukit, Whoasif, Richard Cooper, Harmesh Moudgil, and Nawaid Ahmad. "DRESS syndrome: an important differential for eosinophilia with systemic organ dysfunction." BMJ Case Reports 13, no. 5 (2020): e234251. http://dx.doi.org/10.1136/bcr-2020-234251.

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Drug rash occurring with eosinophilia and systemic symptoms syndrome is a potentially fatal adverse drug reaction that requires immediate action in order to minimise patient harm. Initially implicated with the use of anticonvulsants, it has also been shown to be caused by many other medications but less frequently with vancomycin. Patients typically present with fever, lymphadenopathy, eosinophilia and systemic organ dysfunction. Diagnosis is aided using probability calculators such as RegiSCAR (Registry of Severe Cutaneous Adverse Reaction), as well as clinical response on removing the respon

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Stevens, Jonathan R., Joshua J. Rodgers, and Theodore A. Stern. "Idiosyncratic Adverse Reactions to Psychotropic Medications." Psychiatric Annals 46, no. 8 (2016): 456–65. http://dx.doi.org/10.3928/00485713-20160622-01.

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Fraunfelder, F. T., and S. Martha Meyer. "SYSTEMIC ADVERSE REACTIONS TO GLAUCOMA MEDICATIONS." International Ophthalmology Clinics 29, no. 3 (1989): 143–46. http://dx.doi.org/10.1097/00004397-198902930-00002.

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Bebarta, Vikhyat S., Mark A. Kostic, and Michael G. Gonzalez. "Managing Adverse Reactions to Psychotropic Medications." Pediatric Annals 34, no. 12 (2005): 947–54. http://dx.doi.org/10.3928/0090-4481-20051201-10.

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Duncan, Karynne O. "Severe Cutaneous Adverse Reactions to Medications." Primary Care Case Reviews 4, no. 4 (2001): 171–85. http://dx.doi.org/10.1097/00129300-200112000-00003.

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Bliss, Sarah A., and Julia K. Warnock. "Psychiatric medications: Adverse cutaneous drug reactions." Clinics in Dermatology 31, no. 1 (2013): 101–9. http://dx.doi.org/10.1016/j.clindermatol.2011.11.014.

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Mostovoy, Y. M., and T. D. Danilevych. "PULMONARY ADVERSE REACTIONS OF CARDIOVASCULAR DRUGS." Ukrainian Pulmonology Journal 30, no. 1 (2022): 15–24. http://dx.doi.org/10.31215/2306-4927-2022-30-1-15-24.

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PULMONARY ADVERSE REACTIONS OF CARDIOVASCULAR DRUGS Y. M. Mostovoy, T. D. Danilevych Abstract Diagnosis and treatment of chronic obstructive pulmonary disease, bronchial asthma, pneumonia, idiopathic pulmonary fibrosis is an actual problem in medicine and pulmonology. These diseases are quite often combined with common diseases of the cardiovascular system, in particular, coronary artery disease, hypertension, and heart failure. The supervision of such patients is a difficult problem for the physicians. This review focuses on published data regarding the use of common drugs for the treatment o

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Sonal, Kumbhar1* Nilesh Chougule2 Ayan Sayyad3. "Adverse Drug Reactions to Anti-hypertensive: A Hospital Survey Pharmacovigilance." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 240–47. https://doi.org/10.5281/zenodo.12657664.

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Antihypertensive medications are critical in managing hypertension, a prevalent and potentially life-threatening condition. However, the benefits of these medications can be offset by adverse drug reactions (ADRs), which can significantly affect patient compliance, quality of life, and overall treatment outcomes. This study aims to investigate the incidence, types, and severity of ADRs associated with antihypertensive drugs in a hospital setting, contributing to pharmacovigilance efforts and enhancing patient safety. The survey was conducted on 108 patients. Their mean age is 55.14 years, and

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Wang, Shuai, Anahat Kaur, Mariuxi Alexandra Viteri Malone, Tarek N. Elrafei, Lewis Steinberg, and Abhishek Kumar. "Cancer therapy related dysphonia: Analysis of real-world FAERS data." Journal of Clinical Oncology 39, no. 15_suppl (2021): e18794-e18794. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e18794.

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e18794 Background: Dysphonia is a rare and under-reported adverse event. It is associated with the use of several cancer drugs. Dysphonia has been included as possible side effect on packet insert (PI) for some medications, like regorafenib, lenvatinib and axitinib. However, dysphonia has not been reported on multiple other drugs. We aimed to conduct a more comprehensive study to generate signal for dysphonia as adverse effect of drugs used for oncologic indications. Methods: The United States Food and Drug Administration (FDA) Adverse Events Reporting System (FAERS) database, a pharmacovigila

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Boccardi, Aleia, and Jay H. Shubrook. "Cutaneous Reactions to Antidiabetic Agents: A Narrative Review." Diabetology 3, no. 1 (2022): 97–107. http://dx.doi.org/10.3390/diabetology3010008.

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Diabetes is a common and complex disease affecting multiple organ systems throughout the body. With a consensus in care guidelines emphasizing the importance of glycemic control in determining the disease progression, people with diabetes worldwide have been placed on medication regimens targeting glucose stability from a variety of pathophysiologic pathways. Each of these medications also possesses its own potential for adverse events. In recent years, there has been increased reports of skin reactions to diabetes medications, adding to the more widely known eruptions such as insulin-induced

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