Academic literature on the topic 'Africa (Group 3) Committee'
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Journal articles on the topic "Africa (Group 3) Committee"
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Mouser, Nancy Fox. "Peter Hartwig, 1804-1808: Sociological Perspectives in Marginality and Alienation." History in Africa 31 (2004): 263–302. http://dx.doi.org/10.1017/s0361541300003491.
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All social groups make rules and attempt, at some times and under some circumstances, to enforce them. Social rules define situations and the kinds of behavior appropriate to them, specifying some actions as “right” and forbidding others as “wrong.” When a rule is enforced, the person who is supposed to have broken it may be seen as a special kind of person, one who cannot be trusted to live by the rules agreed on by the group. He is regarded as an outsider.But the person who is thus labeled an outsider may have a different view of the matter. He may not accept the rule by which he is being judged and may not regard those who judge him as either competent or legitimately entitled to do so. Hence, a second meaning of the term emerges: the rule-breaker may feel his judges are outsiders.Peter Hartwig was a German seminarian recruited by the Church Missionary Society in 1803 to serve as one of its first two missionaries in Africa. He was sent to Freetown, a settlement established for Africans and people of African descent who had returned to Africa from Britain and the Americas. Hartwig was to reside at Freetown temporarily and to be supervised while there by a locally-based Corresponding Committee composed of Sierra Leone Company officials. The Society directed that, after a year's residence in Sierra Leone, Hartwig and his fellow recruit Melchior Renner would establish a mission among Susu peoples north of Freetown, where they were to convert indigenous Africans to Christianity. Hartwig, however, failed to meet the Society's expectations, violated the norms of the Corresponding Committee that the Society had established at Freetown to guide mission progress, and left the Society's service within three years of reaching the coast. He seemingly had become unable to adjust to changing realities, a wrongdoer and a moral example to other missionaries of what to avoid becoming.3 How are we to interpret his failure from a sociological perspective?
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Swarthout, Todd D., Ana Ibarz-Pavon, Gift Kawalazira, George Sinjani, James Chirombo, Andrea Gori, Peter Chalusa, et al. "A pragmatic health centre-based evaluation comparing the effectiveness of a PCV13 schedule change from 3+0 to 2+1 in a high pneumococcal carriage and disease burden setting in Malawi: a study protocol." BMJ Open 11, no. 6 (June 2021): e050312. http://dx.doi.org/10.1136/bmjopen-2021-050312.
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IntroductionStreptococcus pneumoniae (the pneumococcus) is commonly carried as a commensal bacterium in the nasopharynx but can cause life-threatening disease. Transmission occurs by human respiratory droplets and interruption of this process provides herd immunity. A 2017 WHO Consultation on Optimisation of pneumococcal conjugate vaccines (PCV) Impact highlighted a substantial research gap in investigating why the impact of PCV vaccines in low-income countries has been lower than expected. Malawi introduced the 13-valent PCV (PCV13) into the national Expanded Programme of Immunisations in 2011, using a 3+0 (3 primary +0 booster doses) schedule. With evidence of greater impact of a 2+1 (2 primary +1 booster dose) schedule in other settings, including South Africa, Malawi’s National Immunisations Technical Advisory Group is seeking evidence of adequate superiority of a 2+1 schedule to inform vaccine policy.MethodsA pragmatic health centre-based evaluation comparing impact of a PCV13 schedule change from 3+0 to 2+1 in Blantyre district, Malawi. Twenty government health centres will be randomly selected, with ten implementing a 2+1 and 10 to continue with the 3+0 schedule. Health centres implementing 3+0 will serve as the direct comparator in evaluating 2+1 providing superior direct and indirect protection against pneumococcal carriage. Pneumococcal carriage surveys will evaluate carriage prevalence among children 15–24 months, randomised at household level, and schoolgoers 5–10 years of age, randomly selected from school registers. Carriage surveys will be conducted 18 and 33 months following 2+1 implementation.AnalysisThe primary endpoint is powered to detect an effect size of 50% reduction in vaccine serotype (VT) carriage among vaccinated children 15–24 months old, expecting a 14% and 7% VT carriage prevalence in the 3+0 and 2+1 arms, respectively.Ethics and disseminationThe study has been approved by the Malawi College of Medicine Research Ethics Committee (COMREC; Ref: P05.19.2680), the University College London Research Ethics Committee (Ref: 8603.002) and the University of Liverpool Research Ethics Committee (Ref: 5439). The results from this study will be actively disseminated through manuscript publications and conference presentations.Trial registration numberNCT04078997.
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Manjunath, Chandrika, Oluwatomilona Ifelayo, Clarence Jones, Monisha Washington, Stanton Shanedling, Johnnie Williams, Christi A. Patten, Lisa A. Cooper, and LaPrincess C. Brewer. "Addressing Cardiovascular Health Disparities in Minnesota: Establishment of a Community Steering Committee by FAITH! (Fostering African-American Improvement in Total Health)." International Journal of Environmental Research and Public Health 16, no. 21 (October 28, 2019): 4144. http://dx.doi.org/10.3390/ijerph16214144.
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Despite its rank as the fourth healthiest state in the United States, Minnesota has clear cardiovascular disease disparities between African-Americans and whites. Culturally-tailored interventions implemented using community-based participatory research (CBPR) principles have been vital to improving health and wellness among African-Americans. This paper delineates the establishment, impact, and lessons learned from the formation of a community steering committee (CSC) to guide the Fostering African-American Improvement in Total Health (FAITH!) Program, a CBPR cardiovascular health promotion initiative among African-Americans in Minnesota. The theory-informed CSC implementation process included three phases: (1) Membership Formation and Recruitment, (2) Engagement, and (3) Covenant Development and Empowerment. The CSC is comprised of ten diverse community members guided by mutually agreed upon bylaws in their commitment to FAITH!. Overall, members considered the CSC implementation process effective and productive. A CBPR conceptual model provided an outline of proximal and distal goals for the CSC and FAITH!. The CSC implementation process yielded four lessons learned: (1) Have clarity of purpose and vision, (2) cultivate group cohesion, (3) employ consistent review of CBPR tenets, and (4) expect the unexpected. A robust CSC was established and was instrumental to the success and impact of FAITH! within African-American communities in Minnesota.
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Chhagan, Usha, Vuyokazi Ntlantsana, Andrew Tomita, Thirusha Naidu, Bonginkosi Chiliza, and Saeeda Paruk. "Investigating the impact of HIV on patients with first episode psychosis: a study protocol for a longitudinal cohort study." BMJ Open 11, no. 5 (May 2021): e046593. http://dx.doi.org/10.1136/bmjopen-2020-046593.
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IntroductionSouth Africa (SA) has a high HIV prevalence and limited mental healthcare resources. Neuropsychiatric complications such as psychosis onset in people living with HIV (PLWHIV) remains poorly understood. The study aims to compare the socio-demographic, clinical, substance use, cognitive and trauma profile of PLWHIV presenting with first episode psychosis (FEP) to those with the condition but without HIV.Methods and analysisThis study will compare presentation, course, and outcome of a cohort of PLWHIV and FEP with a control group recruited over a 3-year period. We will prospectively test the hypothesis that the 2 groups are socio-demographically, clinically and cognitively distinct at illness presentation, with higher trauma burden and poorer outcomes in those with the dual burden of HIV and FEP. FEP participants, confirmed by a structured neuropsychiatric interview, will have their socio-demographic, psychosis, mood, motor, trauma and substance use variables assessed. A neuropsychological battery will be completed to assess cognition, while quality of life, psychotic symptoms and HIV markers will be measured at 3, 6 and 12 months.Ethics and disseminationThe study protocol has been reviewed and ethics approval obtained from the Biomedical Research Ethics Committee (BC 571/18) of the University of KwaZulu-Natal. The results from this investigation will be actively disseminated through peer-reviewed journal publications and conference presentations.
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Mir, Fatima, Apsara Ali Nathwani, Suhail Chanar, Amjad Hussain, Arjumand Rizvi, Imran Ahmed, Zahid Ali Memon, Atif Habib, Sajid Soofi, and Zulfiqar Ahmed Bhutta. "Impact of pulse oximetry on hospital referral acceptance in children under 5 with severe pneumonia in rural Pakistan (district Jamshoro): protocol for a cluster randomised trial." BMJ Open 11, no. 9 (September 2021): e046158. http://dx.doi.org/10.1136/bmjopen-2020-046158.
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BackgroundPneumonia is a leading cause of death among children under 5 specifically in South Asia and sub-Saharan Africa. Hypoxaemia is a life-threatening complication among children under 5 with pneumonia. Hypoxaemia increases risk of mortality by 4.3 times in children with pneumonia than those without hypoxaemia. Prevalence of hypoxaemia varies with geography, altitude and severity (9%–39% Asia, 3%–10% African countries). In this protocol paper, we describe research methods for assessing impact of Lady Health Workers (LHWs) identifying hypoxaemia in children with signs of pneumonia during household visits on acceptance of hospital referral in district Jamshoro, Sindh.Methods and analysisA cluster randomised controlled trial using pulse oximetry as intervention for children with severe pneumonia will be conducted in community settings. Children aged 0–59 months with signs of severe pneumonia will be recruited by LHWs during routine visits in both intervention and control arms after consent. Severe pneumonia will be defined as fast breathing and/or chest in-drawing, and, one or more danger sign and/or hypoxaemia (Sa02 <92%) in PO (intervention) group and fast breathing and/or chest in-drawing and one or more danger sign in clinical signs (control) group. Recruits in both groups will receive a stat dose of oral amoxicillin and referral to designated tertiary health facility. Analysis of variance will be used to compare baseline referral acceptance in both groups with that at end of study.Ethics and disseminationEthical approval was granted by the Ethics Review Committee of the Aga Khan University (4722-Ped-ERC-17), Karachi. Study results will be shared with relevant government and non-governmental organisations, presented at national and international research conferences and published in international peer-reviewed scientific journals.Trial registration numberNCT03588377.
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Mann, S. G., E. V. Raikina, and I. M. Yunusova. "The spectrum of genetic variants of the a- and b-globin clusters in patients with hemoglobinopathies living in the Republic of Dagestan." Pediatric Hematology/Oncology and Immunopathology 19, no. 3 (October 9, 2020): 50–53. http://dx.doi.org/10.24287/1726-1708-2020-19-3-50-53.
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Hemoglobinopathies are a group of hereditary hemolytic anemias common in the countries of the Mediterranean, Southeast Asia and Africa, where malaria was previously common. Due to population migration and an increase in the number of mixed marriages, hemoglobinopathies are also relevant to Russia. Among the Russian Federation's subjects, the Republic of Dagestan is the most endemic region for the incidence of hemoglobinopathies. This study aimed to identify the spectrum of mutations in patients with hemoglobinopathies living in the Republic of Dagestan. The research was approved by Independent ethic committee and the academic board of Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology (Moscow, Russia). Material from 100 patients was sent for molecular genetic research to the Laboratory of Molecular Biology, Federal State Budget Scientific Institution Scientific Research Center for Surgery named after Dmitry Rogachev. Genetic variants of the genes of the a- and b-globin clusters were determined using multiplex ligase-dependent amplification of samples and Sequencing by the Sanger method. Eighteen genetic variants with different frequencies were detected. The mutation frequency of the b-globin cluster was 62.5%, the a-globin cluster was 23.2%, and the variants leading to the appearance of abnormal hemoglobin were 14.3%. The five most common genetic variants among this cohort were also identified: CD8(-AA) and IVSI-110 (G>A), -(a) 3.7 and -(a) 20.5 and the CD6 variant GAG>GTG [Glu>Val] leading to abnormal hemoglobin S.
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Denisova, T. S., and S. V. Kostelyanets. "Warlords to Politicians: The Transformation of Rebel Leaders in Africa (on the Example of Sierra Leone)." Outlines of global transformations: politics, economics, law 13, no. 3 (August 20, 2020): 214–31. http://dx.doi.org/10.23932/2542-0240-2020-13-3-12.
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The paper analyzes the processes of transformation of leaders of rebel movements and tribal militias (warlords) into leaders of political parties and senior government officials after the end of the Civil War (1991‑2002) in Sierra Leone. It is argued that the opportunities for an anti‑government (or, on the contrary, pro‑government) armed group to become an officially recognized political organization, and for erstwhile field commanders to become its leaders, emerge either in the event of a rebel victory or after the signing of a peace agreement (as it happened in Sierra Leone) and the beginning of the integration of former militants into the post‑war society. It is usually the implementation of disarmament, demobilization and reintegration programs that allows former rebels and their leaders to escape punishment for crimes committed during conflicts. At the same time, the opportunity to “earn forgiveness” is not the only incentive for a warlord to evolve into a peacetime politician. Indeed, gaining political power in African countries entails access to various sources of enrichment, and since running armed groups requires their leaders to possess organizational and entrepreneurial skills and charisma ‑ naturally, along with less positive character traits ‑ many warlords who have not yet fulfilled their political ambitions or secured their financial situation try to “adapt” their wartime skills and experience to peaceful life. A proven way of gaining power peacefully is by participating in presidential and parliamentary elections. It is assumed that the development of a political career by former rebels in the context of peacebuilding should prevent the unfolding of another spiral of violence, but this is far from always the case: accustomed to achieving goals by military means, they often attempt to solve political issues through violence in peacetime. The paper considers the reasons for certain former rebel leaders to remain committed to peacebuilding and for other warlords to prove unable to achieve political goals by peaceful means.
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Heeney, Matthew M., David C. Rees, Mariane de Montalembert, Isaac Odame, R. Clark Brown, Yasser Wali, Thu Thuy Nguyen, Du Lam, Raquel Merino Herranz, and Julie Kanter. "Study Design and Initial Baseline Characteristics in Solace-Kids: Crizanlizumab in Pediatric Patients with Sickle Cell Disease." Blood 136, Supplement 1 (November 5, 2020): 22–24. http://dx.doi.org/10.1182/blood-2020-137081.
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Background: Sickle cell disease (SCD) is a group of genetic blood disorders characterized by hemolytic anemia, multi-organ damage and acutely painful events (vaso-occlusive crises [VOCs]) that can cause life-threatening complications. Vaso-occlusion is mediated, in part, by P-selectin, an adhesion molecule expressed on endothelial cells and platelets. Adults and children with SCD have similar P-selectin expression levels; however, disease severity worsens with increasing age because of cumulative endothelial damage caused by repeated vaso-occlusion events. Crizanlizumab is a humanized anti-P-selectin monoclonal antibody that binds P-selectin and blocks its interaction with its ligands. SUSTAIN, a Phase 2 study in adults with SCD, has shown that crizanlizumab, compared with placebo, is well tolerated and significantly decreases the number of VOCs requiring a healthcare visit (Ataga et al. N Engl J Med 2017). Aim: To describe the design of the first crizanlizumab study in pediatric patients (pts) with SCD and report demographics and baseline characteristics of a subset of enrolled pts (aged 6 to <18 yr) (ClinicalTrials.gov: NCT03474965). Methods: Primary objectives of this Phase 2, multicenter, open-label study are to confirm crizanlizumab dosing and assess safety. Pts aged 6 mo to <18 yr with a confirmed SCD diagnosis (any genotype) and ≥1 VOC within the preceding 12 mo are included. The study will enroll ≥100 pts in 3 age groups: Group 1 (G1; 12 to <18 yr), 2 (G2; 6 to <12 yr), and 3 (G3; 6 mo to <6 yr). Crizanlizumab is administered intravenously on weeks 1 and 3, and every 4 weeks thereafter for up to 2 years. Dose confirmation is being determined by single- and multiple-dose pharmacokinetic (PK) data and key safety data. Steady state PK, pharmacodynamic (PD) and safety data are used to validate the confirmed dose or prompt modifications, if required. Secondary objectives include assessment of crizanlizumab efficacy, measured by annualized rate of VOCs leading to a healthcare visit (clinic, emergency room [ER] or hospital), and annualized rate of VOCs managed at home. VOC subcategories (uncomplicated pain crisis, acute chest syndrome, hepatic and splenic sequestration, and priapism), overall hospitalizations and ER visits and dactylitis events are also assessed. Safety measures include frequency and severity of adverse events. Long-term PK and PD will also be characterized by measuring pre-dose concentrations and percentage of P-selectin inhibition prior to each study drug dose. Part A in each age group will confirm PK dose, beginning with ≥8 pts in G1. If unconfirmed, dose will be adjusted based on population PK model, and ≥8 additional pts enrolled. Once dose is confirmed, recruitment will be expanded for long-term safety and efficacy evaluation of the PK confirmed dose (Part B). This process will then repeat for G2 then G3 (2 to <6 yr). Subsequently, ≥6 G3 pts aged 6 mo to <2 yr will be enrolled, with only pre-dose PK/PD samples collected. Pts on hydroxyurea, L-glutamine or an erythropoietin-stimulating agent must have received the treatment for ≥6 mo prior to screening with no dosage or schedule adjustments during the study. Pts not currently on such drugs must have been off them for ≥6 mo prior to screening. Pts who have received prior crizanlizumab treatment are excluded from the trial. Results: As of January 28, 2020, 59 pts were enrolled: 46 pts in G1 (11 pts in Part A and 35 pts Part B) and 13 pts in G2 Part A. Pt demographics are available for Part A in G1 and 2 (Table), based on 2 Data Monitoring Committee analyses. The median age of G1 was 17.0 yr (range 13-17), 6 (54.5%) were male and 11 (100%) were Black/African American. 9 (81.8%) had HbSS disease, 1 (9.1%) HbSC and 1 (9.1%) HbSβ0. The median age of G2 was 9.0 yr (range 6-11), 8 (61.5%) were male, 7 (53.8%) were Black/African American, 4 (30.8%) were White, and 2 were of multiple race, specifically 'White, Asian' (n=1, 7.7%) and 'White, Black/African American' (n=1, 7.7%). 12 (92.3%) pts had HbSS disease and 1 (7.7%) had HbSC. Conclusions: This study aims to address an unmet treatment need in pediatric pts, exploring appropriate dosing and the safety of crizanlizumab. The annualized rates of VOCs, hospitalizations and ER visits will be assessed as secondary objectives. The primary analyses for Parts A and B of G1 and 2, and then G3, will occur consecutively when all pts enrolled in each group have either completed 26 weeks of treatment or discontinued the study treatment. Disclosures Heeney: UpToDate: Patents & Royalties: Author royalties; Micelle: Consultancy, Other; Keros: Consultancy; Novartis: Consultancy, Other; AstraZeneca: Consultancy, Other; Cyclerion: Consultancy, Other; Forma Therapeutics: Consultancy; Dova: Consultancy; Global Blood Therapeutics: Consultancy; Emerging Therapy Solutions (ETS): Consultancy. Rees:Alnylam Pharmaceuticals: Consultancy, Honoraria; Novartis: Consultancy, Honoraria; AstraZeneca: Other: Data monitoring committee membership; Emmanus Medical: Consultancy, Honoraria; TauRx: Other: Data And Safety Monitoring. de Montalembert:Vertex: Honoraria, Membership on an entity's Board of Directors or advisory committees; Bluebird bio: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees; Addmedica: Honoraria, Membership on an entity's Board of Directors or advisory committees. Odame:Novo Nordisk: Other: Study Advisory Board; Global Blood Therapeutics: Other: Study Data Safety Monitoring Board; Novartis: Other: Study Steering Committee. Wali:Novartis: Research Funding. Nguyen:Novartis: Current Employment. Lam:Novartis: Current Employment. Herranz:Novartis: Current Employment. Kanter:NHLBI Sickle Cell Advisory Board: Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy; bluebird bio, inc: Consultancy, Honoraria; SCDAA Medical and Research Advisory Board: Membership on an entity's Board of Directors or advisory committees; AGIOS: Membership on an entity's Board of Directors or advisory committees; BEAM: Membership on an entity's Board of Directors or advisory committees; Guidepoint Global: Honoraria; Cowen: Honoraria; Jeffries: Honoraria; Wells Fargo: Honoraria; Medscape: Honoraria; GLG: Honoraria; Sanofi: Consultancy. OffLabel Disclosure: Crizanlizumab is a monoclonal antibody to P-selectin indicated in the USA for the prevention of vaso-occlusive crises in patients aged 16 years and over with sickle cell disease. This abstract described the new pediatric trial of crizanlizumab, which is not indicated for patients aged less than 16 years of age
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Ferhanoglu, Burhan, Tae Min Kim, Amado Karduss, David Brittain, Gayane Tumyan, Mubarak Al Mansour, Marta Zerga, et al. "Results from the International, Multi-Center, Retrospective B-Holistic Study: Describing Treatment Pathways and Outcomes for Classical Hodgkin Lymphoma." Blood 136, Supplement 1 (November 5, 2020): 32–34. http://dx.doi.org/10.1182/blood-2020-134885.
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Background: Despite therapeutic advances in classical Hodgkin lymphoma (cHL), only half of patients with relapsed/refractory (R/R) cHL are cured with salvage chemotherapy followed by stem cell transplantation (SCT). Most studies to date have been undertaken in Europe or North America and data on treatment patterns and clinical outcomes from other regions are limited. We present the results from the B-CD30+ HOdgkin Lymphoma International Multi-center Retrospective Study of Treatment PractIces and OutComes (B-HOLISTIC), which assessed cHL treatment pathways, clinical outcomes and healthcare resource utilization across East Asia, Latin America, Middle East, South Africa, Australia and Russia (data as of 04 March 2020). Methods: Data were collected retrospectively for patients (≥18 years) diagnosed with stage IIB-IV cHL or R/R cHL between 01 January 2010 and 31 December 2013, until death or last follow-up (whichever occurred first) across 13 countries. Patients with initial diagnosis of cHL and subsequent progression to R/R cHL were included in both groups, provided R/R cHL was diagnosed within the study period. The primary endpoint was progression-free survival (PFS) in patients with R/R cHL. Secondary endpoints included overall survival (OS), best clinical response, and adverse events (AEs). Results: In total, 1703 patients were enrolled from East Asia (n=426), Latin America (n=366), Middle East and South Africa (n=694), Australia (n=56) and Russia (n=161): 1598 and 426 patients were eligible for the cHL and R/R cHL groups (321 patients in the cHL group progressed to R/R cHL and were included in both groups). Median study follow-up was 65.2 and 53.2 months for the cHL and R/R cHL groups. Baseline patient characteristics are shown in Table 1. All patients in the cHL group received first-line chemotherapy: the most common regimens were ABVD (1363/1598; 85.3%) and BEACOPP (104/1598; 6.5%). First-line radiotherapy was given to 357/1598 (22.3%) patients in the cHL group. For R/R cHL, intensive chemotherapy was used as first-line salvage in 372/426 (87.3%) patients: the most common regimens were ESHAP (98/372; 26.3%) and DHAP (65/372; 17.5%), with an overall response rate of 62.0% (complete remission in 30.8% and partial remission in 31.2%). Of the 426 patients with R/R cHL, 292 (68.5%) were eligible for SCT at relapse/refractory diagnosis; 10 patients who were initially ineligible for SCT subsequently became eligible. In total, 222/302 (73.5%) eligible patients underwent SCT; 63/222 (28.4%) patients relapsed after SCT. Median PFS (95% CI) for the R/R cHL group was 13.2 (9.9-20.2) months following initial therapy (Figure 1), with estimated 1-, 3- and 5-year PFS rates of 51.2%, 38.7%, and 33.9%, respectively (Table 2). Median PFS was not reached for the first-line cHL group. Factors for PFS in the R/R cHL group are shown in Table 3. Median OS was not reached for both groups. All-cause, any grade AEs were reported by 783/1598 (49.0%) patients with cHL and by 233/426 (54.7%) patients with R/R cHL. Serious AEs were reported by 303/1598 (19.0%) patients with cHL and by 103/426 (24.2%) patients with R/R cHL: the most common (≥2.0%) were febrile neutropenia, pneumonia and pyrexia for cHL, and febrile neutropenia and pyrexia for R/R cHL. Conclusion: Results from B-HOLISTIC show that PFS rates remain low in patients with R/R cHL receiving salvage therapy; the greatest risk was among patients with inadequate response to salvage chemotherapy. The low PFS rates highlight the importance of considering novel targeted therapies to address unmet medical needs. PFS rates in patients with cHL were comparable with previous studies from Italy, Spain, and Israel (Avigdor A et al. EHA 2020) and the ECHELON-1 study (Bartlett NL et al. ASH 2019). The higher OS rates compared to PFS rates may be related to the effect of modern salvage regimens. Approximately half of patients with R/R cHL underwent SCT which may support the use of targeted therapies. Overall, these results from 2010-2013 show that despite the differences in healthcare systems, ethnicities and treatment patterns in B-HOLISTIC, clinical outcomes remain consistent. The authors note that given that the management of high-risk cHL has changed dramatically since 2013, further investigation in diagnostic criteria, response assessment and treatment patterns is needed. Study support: Data analysis (IQVIA) and medical writing (Synergy Vision) funded by Takeda Pharmaceuticals. Disclosures Ferhanoglu: Takeda: Other: Advisory Board; Abbvie: Other: Advisory Board; Roche: Other: Advisory Board; Janssen: Other: Advisory Board. Kim:Novartis: Consultancy; AstraZeneca and Korea Health Industry Development Institute: Research Funding; Sanofi: Consultancy; F. Hoffmann-La Roche Ltd/Genentech, Inc.: Consultancy; Voronoi: Consultancy; Boryung: Consultancy; AstraZeneca: Consultancy; Takeda: Consultancy. Karduss:Takeda: Honoraria. Rivas-Vera:Takeda: Current Employment, Other: Steering Committee in Clinical Research; Roche: Consultancy. Lim:National Cancer Centre Singapore: Current Employment. Yeh:AbbVie: Membership on an entity's Board of Directors or advisory committees; Amgen: Membership on an entity's Board of Directors or advisory committees; Janssen: Membership on an entity's Board of Directors or advisory committees; Astellas: Membership on an entity's Board of Directors or advisory committees; Astex: Membership on an entity's Board of Directors or advisory committees. Abdillah:Takeda: Current Employment. Huang:Takeda: Current Employment. Dalal:Takeda: Current Employment, Current equity holder in publicly-traded company. Wan:Takeda: Current Employment. Hertzberg:Roche: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Support of parent study and funding of editorial support; Gilead: Membership on an entity's Board of Directors or advisory committees; MSD: Membership on an entity's Board of Directors or advisory committees; Abbvie: Honoraria; BMS: Honoraria; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees.
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Trompetter, Linda, Arthur Breese, James Calderone, Grace S. Fisher, Rodrigo Gereda, Mari King, Richard Kramer, et al. "Focus Group Study of Diverse Local Populations and Their Health Care Experiences in Northeastern Pennsylvania." Californian Journal of Health Promotion 3, no. 3 (September 1, 2005): 73–126. http://dx.doi.org/10.32398/cjhp.v3i3.650.
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This investigation was conducted through the support of the College Misericordia Diversity Institute and a grant from the Blue Ribbon Foundation of Blue Cross of Northeastern Pennsylvania. Focus group participants were 49 adults from seven minority populations residing in northeastern Pennsylvania’s Luzerne and Lackawanna counties. Data was collected by 11 focus group leaders who were members of a Blue Ribbon Grant Core Committee at College Misericordia in 2004. The seven populations studied were African Americans, Arabic Muslims, Asian-Chinese and Korean, Gay and Lesbian, Hispanic, Jewish, and Asian Indian. A 30-question survey was used to collect data during one to two hour focus group interviews. Through content analysis, six problematic issues faced by many of the participants were identified. All of the findings were validated by a review process. The six issues faced by the 7 groups were: 1) Economics, Education, and Employment Influence Life for Newcomers, 2) Customs and Traditions Sometimes Sacrificed- The Influence of American Culture, 3) Socialization Often Limited to Same Population Group, 4) Mixed Acceptance Level from Area Natives, 5) Bilingual Challenges Impede Optimal Inclusion, 6) Health Care Access Problems. The aforementioned cross-groups study is explored in this report. The study also yielded seven other reports (one for each diverse population) which provide a description of that particular focus group’s perspective on topics such as religion, food, family, customs, and health care (see Appendices A, B, C, D, E, F, and G). Findings of this study are being disseminated in a local effort to educate health care professionals. Future research will be needed to determine if progress is being made in fulfilling the health care needs of all diverse populations living in Luzerne and Lackawanna County, as well as other parts of northeastern Pennsylvania.
Dissertations / Theses on the topic "Africa (Group 3) Committee"
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Tshuma, Sibhekinkosi Anna. "Reading clubs as a literacy intervention tool to develop English vocabulary amongst Grade 3 English second language learners at a school in Grahamstown, Eastern Cape." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1011755.
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This study is part of a larger research programme that seeks to contribute towards an understanding of South Africa's complex literacy landscape and formulate strategies that may address these particularly in the Foundation Phase. It is a case study of one public primary school in Grahamstown where isiXhosa is used as a medium of instruction until Grade 3, after which the medium of instruction changes to English. This transition is not helped by the little reading that happens in the language at the FP. The learners under study are Grade 3 isiXhosa first language speakers, learning English as a First Additional Language (FAL) with limited exposure to the language. Through a qualitative participatory action research process, the study investigated the extent to which a reading club in general and a responsive reading programme in particular, might develop learners' English vocabulary at this particular school. The value of reading clubs as a vehicle for second language learning as well as the importance of considering learner needs in the development of the reading programme are key contributions this study makes. The study draws on social constructivism as a theoretical framework based on the principle that learning is a social acitvity. Vygotsky (1978) states that language learning (LL) takes place through interactions in meaningful events, rather that through isolated language activities. The process is seen as holistic, that is, each mode of language supoorts and enhances overall language development. Furthermore, LL develops in relation to the context in which it is used, that is, it develops according to the situation, the topic under discussion and the relationship betwwen participants. Language also develops through active engagement of the learners. The role of the teacher or a more competent other is then seen as that of a facilitator in a learning context in which learners are viewed as equally capable of contributing to their learning through learning from and with each other (Holt and Willard-Holt, 2000). Vygotsky's theory of social interaction has been influential in highlighting the important role of social and cultural contexts in extending children's learning. The preliminary results of this study point toward the importance of the learning environment, particularly an informal environment in second language development. The results also highlight the need for learners (a) to be provided with opportunities to engage with meaningful and authentic texts, (b) to be allowed to make their own book choices, (c) to participate in large group, small group and individual activities to enable them to engage with a variety of texts, and (d) to confront vocabulary in a variety of ways through multiple texts and genres.
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Cass, Nicolize. "Monitoring longitudinal behaviour of impedance and Neural Response Telemetry measurements in a group of young cochlear implant users." Diss., University of Pretoria, 2010. http://hdl.handle.net/2263/26097.
Full textAbstract:
Electrophysiological measures such as impedance telemetry and Neural Response Telemetry (NRT™) were developed by Cochlear™ in 1992 as clinical tools allowing the objective setting of stimulus levels for cochlear implant users. Extensive research proved the usefulness of NRT™’s as an aid in the programming process of audible and comfortable stimulus levels for children younger than six years. The Nucleus® Freedom™, launched in 2005, introduced new developments in cochlear implantation. Approval from the FDA for this system was obtained in March 2005 and for the first time included children from age 12 months with profound hearing loss. The Joint Committee on Infant Hearing suggested that children be diagnosed and that treatment commenced by the age of six months. The new features of the Nucleus Freedom™ give clinicians the necessary tools to treat this challenging population. An urgent need exists to ascertain the stability and accuracy of the new features introduced by this system, especially the Auto-NRT™ software, to validate its use within the paediatric population. A longitudinal descriptive design was utilized implementing quantitative research methods to critically describe the behaviour of impedance telemetry and NRT™’s in a group of young cochlear implant users. The quantitative method included the application of the Custom Sound™ software and the Auto-NRT™ feature for this group at implantation, device activation, and then at determined follow-up visits. Nine young children between nine months and five years and eleven months were used as participants during the twelve months of research. Impedance telemetry was described in terms of the mean Common Ground (CG) and Monopolar 1+2 (MP1+2) values calculated from measurement data collected on the basal, medial, and apical electrodes of the electrode array. The electrodes identified for statistical procedures for both measurement types were E3, E6, E8, E11, E13, E16, E19 and E21. Friedman’s ANOVA was used as a statistical measure to determine the level of significance in changes among the measurement modes and conditions. The Wilcoxon signed-rank test was indicated in the presence of significant changes identified by Friedman’s ANOVA to calculate the level of significance in a pair-wise comparison. Results indicate that impedance telemetry remained consistent over the electrode array and over time in both measurement modes. A slight increase in mean values was observed during the first three months, followed by a gradual decrease at the six months interval. These changes were statistically nonsignificant. No specific trends were evident in impedance telemetry over time. NRT™-measurements remained consistent across the electrode array over time. Significant changes were present between the intra-operative to device activation measurement intervals. This trend is also described in studies of adult cochlear implant users. NRT™-measurements were stable during the first year postimplantation within the paediatric population. A comparison between the mean impedance telemetry and NRT™’s disclosed an inverse trend during the first six months post-implantation. Most changes were non-significant, indicating that these measures can be used effectively in the new semi-automated fitting software. The implementation of these measurements can lead to streamlined and accountable service delivery to young cochlear implant users. AFRIKAANS : In 1992 is elektrofisiologiese metings soos impedanstelemetrie en Neurale Respons Telemetrie (NRT™) deur Cochlear™ ontwikkel as kliniese hulpmiddels om objektiewe instelling van stimulasievlakke vir kogleêre gebruikers moontlik te maak. Navorsing het bewys dat NRT™’s ‘n effektiewe hulpmiddel is tydens programmering van hoorbare en gemaklike stimulasievlakke by kinders jonger as ses jaar. Die Nucleus® Freedom™ met nuwe ontwikkelings ten opsigte van kogleêre inplantings is in 2005 bekendgestel. Die FDA het in Maart 2005 hierdie sisteem goedgekeur vir gebruik by kinders selfs so jonk as 12 maande met uitermatige gehoorverlies. Die Joint Committee on Infant Hearing het voorgestel dat diagnose en aanvang van rehabilitasie teen ses maande ouderdom moet plaasvind. Die nuwe funksies van die Nucleus® Freedom™ stel oudioloë in staat om hierdie uitdagende bevolking te hanteer. ‘n Dringende behoefte bestaan om te bepaal of hierdie sagteware, veral Auto-NRT™ wat saam met hierdie sisteem bekendgestel is, oor voldoende akkuraatheid en stabiliteit beskik om in die hantering van die pediatriese bevolking te gebruik. ‘n Longitudinale, beskrywende ontwerp, wat kwantitatiewe metodes implementeer, is aangewend om die beweging van impedanstelemetrie en NRT™’s by ‘n groep jong gebruikers van kogleêre inplantings krities te beskryf. Dit het die gebruik van die Custom Sound™ sagteware en die ingeslote Auto- NRT™ funksie behels. Dit is tydens inplantering, by aktivering van die toestel, en bepaalde opvolgsessies uitgevoer. Nege jong kinders tussen die ouderdomme van nege maande en vyf jaar en 11 maande is tydens die 12 maande navorsingsperiode as proefpersone benut. Die impedansmetings is beskryf in terme van die Common Ground (CG) en Monopolar 1+2 (MP1+2) stimulasiemodaliteite. Data is verkry vanaf geselekteerde elektrodes op die basale, mediale en apikale gedeeltes van die elektrode. Vir statistiese ontledings van impedans en NRT™ is hierdie elektrodes geselekteer: E3, E6, E8, E11, E13 E16, E19 en E21. As statistiese ontledingsmetode, is Friedman se ANOVA toegepas om die vlakke van beduidenheid van beweging tussen die verskillende toetsmodaliteite en -omstandighede te bepaal. Die Wilcoxon signed-rank toets is aangedui in die teenwoordigheid van statisties beduidende veranderinge. Die doel van hierdie toets was om die vlak van beduidenheid paarsgewys te verifieer. Resultate dui op konstante impedansmetings oor die elektrode asook oor tyd in beide toetsmodaliteite. ‘n Geringe, statisties nie-beduidende, verhoging in gemiddelde waardes is waargeneem tydens die eerste drie maande na inplantering, waarna die waardes weer geleidelik afgeneem het tot en met die ses maande opvolginterval. Geen spesifieke neiging kon vir impedanstelemetrie bepaal word nie. NRT™-metings het konstant gebly oor die elektrode en met tyd. Statisties beduidende veranderinge is gemeet tussen die intra-operatiewe en aktiveringsintervalle. Hierdie neiging is ook beskryf in studies van volwasse gebruikers van kogleêre inplantings. NRT™-metings, binne die pediatriese populasie, het dus stabiel gebly oor die 12 maande periode post-inplantering. ‘n Vergelyking tussen die gemiddelde impedans- en NRT™-metings het ‘n inverse neiging geïdentifiseer gedurende die eerste ses maande na inplantering. Veranderinge was oor die algemeen statisties nie-beduidend, wat daarop dui dat hierdie metings effektief gebruik kan word. Die implementering van hierdie metings kan meer doeltreffende dienslewering aan die jong gebruikers van kogleêre inplantings tot gevolg hê.Dissertation (MCommunication Pathology)--University of Pretoria, 2010.
Speech-Language Pathology and Audiology
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Kinuthia, Wanyee. "“Accumulation by Dispossession” by the Global Extractive Industry: The Case of Canada." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30170.
Full textAbstract:
This thesis draws on David Harvey’s concept of “accumulation by dispossession” and an international political economy (IPE) approach centred on the institutional arrangements and power structures that privilege certain actors and values, in order to critique current capitalist practices of primitive accumulation by the global corporate extractive industry. The thesis examines how accumulation by dispossession by the global extractive industry is facilitated by the “free entry” or “free mining” principle. It does so by focusing on Canada as a leader in the global extractive industry and the spread of this country’s mining laws to other countries – in other words, the transnationalisation of norms in the global extractive industry – so as to maintain a consistent and familiar operating environment for Canadian extractive companies. The transnationalisation of norms is further promoted by key international institutions such as the World Bank, which is also the world’s largest development lender and also plays a key role in shaping the regulations that govern natural resource extraction. The thesis briefly investigates some Canadian examples of resource extraction projects, in order to demonstrate the weaknesses of Canadian mining laws, particularly the lack of protection of landowners’ rights under the free entry system and the subsequent need for “free, prior and informed consent” (FPIC). The thesis also considers some of the challenges to the adoption and implementation of the right to FPIC. These challenges include embedded institutional structures like the free entry mining system, international political economy (IPE) as shaped by international institutions and powerful corporations, as well as concerns regarding ‘local’ power structures or the legitimacy of representatives of communities affected by extractive projects. The thesis concludes that in order for Canada to be truly recognized as a leader in the global extractive industry, it must establish legal norms domestically to ensure that Canadian mining companies and residents can be held accountable when there is evidence of environmental and/or human rights violations associated with the activities of Canadian mining companies abroad. The thesis also concludes that Canada needs to address underlying structural issues such as the free entry mining system and implement FPIC, in order to curb “accumulation by dispossession” by the extractive industry, both domestically and abroad.
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Rankwana, Edward Martin. "Invloed van die beleid van afsonderlike ontwikkeling op die ontstaan, ontwikkeling en ontbinding van die Geluksdal Bestuurskomitee." Diss., 1997. http://hdl.handle.net/10500/17587.
Full textAbstract:
The study was undertaken to determine the influence of the
policy of separate development on the establishment,
development and disestablishment of the Geluksdal Management
Committee.
The policy of separate development as implemented by the
previous National Party Government led to the establishment of
the Geluksdal Management Committee. Acts adopted by
Parliament provided the statutory environment for the
establishment of the Geluksdal township and the development of
the Geluksdal Management Committee.
The adoption of the Local Government Transition Act, 1993 (Act
209 of 1993) and the Constitution of the Republic of South Africa,
1993 (Act 200 of 1993) led to the disestablishment of the
Geluksdal Management Committee. In terms of the Local
Government Transition Act, 1993 (Act 209 of 1993) the
Transitional Local Council of Brakpan, that includes the Geluksdal
Management Committee, was promulgated.Die studie is onderneem om die invloed van die beleid van afsonderlike ontwikkeling op die ontstaan, ontwikkeling en ontbinding van die Geluksdal Bestuurskomitee te bepaal. Die beleid van afsonderlike ontwikkeling soos toegepas deur die destydse Nasionale Party Regering het gelei tot die ontstaan van die Geluksdal Bestuurskomitee. Parlementere wetgewing het die statutere omgewing verleen waarbinne die dorp Geluksdal gestig en die Geluksdal Bestuurskomitee ontwikkel het. Die aanvaarding van die Oorgangswet op Plaaslike Regering, 1993 (Wet 209 van 1993) en die Grondwet van die Republiek van Suid-Afrika, 1993 (Wet 200 van 1993) het gelei tot die ontbinding van die Geluksdal Bestuurskomitee. In terme van eersgenoemde Wet is die Oorgangsraad van Brakpan wat die Geluksdal Bestuurskomitee insluit, gepromulgeer.
Public Administration
M.A. (Pulic Administration)
Books on the topic "Africa (Group 3) Committee"
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International Commission on Radiological Protection. Protection of the patient in nuclear medicine: A report of a Task Group of Committee 3 of the International Commission on Radiological Protection. Oxford: Published for the ICRP by Pergamon Press, 1987.
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3, International Commission on Radiological Protection Committee. Radiological protection of the worker in medicine and dentistry: A report of a Task Group of Committee 3 of the International Commission on Radiological Protection. Oxford: Published for the International Commission on Radiological Protection by Pergamon Press, 1990.
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Relations, United States Congress Senate Committee on Foreign. U.S. policy toward South Africa: Hearing before the Committee on Foreign Relations, United States Senate, One Hundred First Congress, first session, October 3, 1989. Washington: U.S. G.P.O., 1990.
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United States. Congress. Senate. Committee on Foreign Relations. U.S. policy toward South Africa: Hearing before the Committee on Foreign Relations, United States Senate, One Hundred First Congress, first session, October 3, 1989. Washington: U.S. G.P.O., 1990.
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United States. Congress. Senate. Committee on Foreign Relations. U.S. policy toward South Africa: Hearing before the Committee on Foreign Relations, United States Senate, One Hundred First Congress, first session, October 3, 1989. Washington: U.S. G.P.O., 1990.
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U.S. policy toward South Africa: Hearing before the Committee on Foreign Relations, United States Senate, One Hundred First Congress, first session, October 3, 1989. Washington: U.S. G.P.O., 1990.
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Relations, United States Congress Senate Committee on Foreign. U.S. policy toward South Africa: Hearing before the Committee on Foreign Relations, United States Senate, One Hundred First Congress, first session, October 3, 1989. Washington: U.S. G.P.O., 1990.
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8
GM and Chrysler dealership closures: Protecting dealers and consumers : hearing before the Committee on Commerce, Science, and Transportation, United States Senate, One Hundred Eleventh Congress, first session, June 3, 2009. Washington: U.S. G.P.O., 2010.
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Expert Group Meeting on Africa and the Establishment of a New Intenational Financial Architecture: Challenges and Opportunities (2010 Gaborone, Botswana). Expert Group Meeting on Africa and the Establishment of a New Intenational Financial Architecture: Challenges and opportunities : 3-4 June, 2010, Gaborone, Botswana : background paper : the reform of the international financial architecture and the policy implications for Africa. Addis Ababa: United Nations, Economic Commission for Africa, 2010.
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Africa Regional Coordinating Committee for the Integration of Women in Development. Meeting. Report of the seventh meeting of the Africa Regional Coordinating Committee for the Integration of Women in Development [held in] Yaoundé, Cameroon, 3-5 April 1986. [S.l.]: [United Nations Economic and Social Council], 1986.
Find full textBook chapters on the topic "Africa (Group 3) Committee"
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Fleming, Robert S., and Michelle Kowalsky. "Working with Committee Group Dynamics." In Springer Texts in Education, 77–81. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80939-3_15.
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Roberts, Leigh, Wayne van Zijl, and Dannielle Cerbone. "The Integrated Reporting Committee of South Africa." In The Routledge Handbook of Integrated Reporting, 37–66. 1 Edition. | New York : Routledge, 2020.: Routledge, 2020. http://dx.doi.org/10.4324/9780429279621-3.
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Gedil, Melaku, Leena Tripathi, Marc Ghislain, Morag Ferguson, Marie-Noelle Ndjiondjop, Lava Kumar, Bodo Raatz, et al. "Biotechnology Success Stories by the Consultative Group on International Agriculture Research (CGIAR) System." In Biotechnology in Africa, 95–114. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-04001-1_6.
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Rott, Hans-Dieter. "Meetings of the European Committee for Ultrasonic Safety Questions (Watchdog Group)." In Bioeffect, 2. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-72986-7_2.
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Wasunna, Monique, Aïssatou Toure, and Christine Wasunna. "Bioethics Development in Africa: The Contributions of the UNESCO International Bioethics Committee." In Global Bioethics: The Impact of the UNESCO International Bioethics Committee, 175–83. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-22650-7_16.
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Akokpari, John. "The EU and Africa: The Political Economy of an Asymmetrical Partnership." In The ACP Group and the EU Development Partnership, 55–77. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-45492-4_3.
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Adebajo, Adekeye. "The EU’s Security Role in Africa: “The Emperor Has No Clothes”." In The ACP Group and the EU Development Partnership, 213–34. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-45492-4_9.
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Puwana, Zukiswa, and Rita Kesselring. "Persistent Injuries, the Law and Politics: The South African Victims’ Support Group Khulumani and Its Struggle for Redress." In Advocating Transitional Justice in Africa, 91–110. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-70417-3_5.
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Carim, Xavier. "South Africa, the EU, and the SADC Group Economic Partnership Agreement: Through the Negotiating Lens." In The ACP Group and the EU Development Partnership, 161–79. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-45492-4_7.
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Cilliers, Jakkie. "Closing the Gap." In The Future of Africa, 381–406. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-46590-2_16.
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AbstractIn this concluding chapter Cilliers presents a combined Close the Gap scenario that integrates the eleven scenarios that were modelled in the previous chapters and compares the impact with the Current Path prospects on dimensions such as income growth, economic size, impact on extreme poverty and carbon emissions. The chapter then moves on to compare the impact of the scenarios with one another. The results differ for low, lower-middle and upper-income countries as well as over time. The differences are illustrated with reference to improvements for each income group in 2030, 2040 and 2050. The chapter then sketches out a broad description of a ‘standard economic growth model’ that emerges from the preceding analysis. It concludes by pointing to the similarities and differences compared to China’s recent history.
Conference papers on the topic "Africa (Group 3) Committee"
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Muratshina, Ksenia. "CHINA - SOUTH AFRICA: EQUAL PARTNERSHIP OR MIRROR OF NEOCOLONIAL PRC POLICY TRENDS IN AFRICA?" In Globalistics-2020: Global issues and the future of humankind. Interregional Social Organization for Assistance of Studying and Promotion the Scientific Heritage of N.D. Kondratieff / ISOASPSH of N.D. Kondratieff, 2020. http://dx.doi.org/10.46865/978-5-901640-33-3-2020-169-178.
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The article analyzes the main directions of interaction between the People's Republic of China and one of its partners in the BRICS group - the Republic of South Africa - at the present stage. The main areas of interaction, problems and results of cooperation are considered.
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Toluse, Williams, Victor Okolo, and Amarquaye Martey. "Production Optimization in a Marginal Field through Established Reservoir Management Techniques – A Case Study." In SPE/AAPG Africa Energy and Technology Conference. SPE, 2016. http://dx.doi.org/10.2118/afrc-2568647-ms.
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ABSTRACT The Federal Government of Nigeria in a bid to promote indigenous companies participation in the oil and gas sector, and to grow the nation’s production capacity passed legislation in 1999 to foster the exploitation of Marginal Oil Fields (MOFs). MOF is one that is considered non – commercial as a result of strategic business development philosophy of the operator, often times large oil companies. Reservoir management is central to the effective exploitation of any hydrocarbon asset; this dependence is heightened for an undeveloped marginal field. There is no ‘one-size fits all’ approach to reservoir management; this paper reviews some techniques adopted by Midwestern Oil and Gas Ltd in the development of the Umusadege marginal field. These techniques fall under three categories: (I) subsurface study (II) well placement and spacing, (III) integrated surface production and optimization, in accordance with regulatory practices. The previously acquired 3-D seismic data was reprocessed and interpretation of reservoir heterogeneities within the Umusadege field concessionary boundary carried out form the basis of the initial field development plan. To optimize reservoir drainage, the general principles of non-interference well spacing were employed, and advanced well placement technology was deployed to guarantee optimum well placement within the reservoir for effective and efficient drainage. Subsequently, 14 vertical wells and 4 horizontal wells were drilled to effectively optimize recovery from the field. Prior to bringing these wells on-stream, clean-up and Maximum Efficiency Rate (MER) tests were conducted to determine the optimum choke settings, GOR and water cut limits for all wells. An integrated approach encompassing choke sizing, gas and water production management, vessel and line sizing were implemented on the Umusadege field to maintain and optimize recovery. Crude custody transfer measurements and export were enabled by an optimized Group Gathering Facility (GGF).The above techniques combining new technologies, traditional reservoir and production strategies led to the successful development of the Umusadege field; increasing daily oil production from 2,000 bbls/d from the first well re-entry to approximately 30,000 bbls/day over a 7-year period. This case study proves that with the correct implementation of the key elements of reservoir management the value of any hydrocarbon asset can be maximized in a cost effective, safe and environmentally friendly manner.
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Farrell, Ronald, and Jason Lambin. "An Overview of ASME Section III Class 2 and 3 Valve Design and Service Loading Rules." In ASME 2020 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/pvp2020-21285.
Full textAbstract:
Abstract In addition to providing an overview of the ASME Boiler and Pressure Vessel Code design rules applicable to Class 2 and 3 valves, where Class is defined in Section III of the ASME Code, Sub-Article NCA-2130, this paper offers some insight as to why the rules are as they are. The motivation comes from a request by the ASME Codes and Standards Committee, Components Subgroup, for the Valve Working Group to prepare this overview. The request came after discussing a question from a participant regarding how the “(Primary Membrane or Local) plus Bending” stress category should be addressed for a valve. The paper goes beyond a basic overview of Code rules as it includes a discussion of the underlying valve standard ASME B16.34, looks at the valve rules in relation with the rest of the Code, and contributes some historical perspective. From a perusal of the Code both in general and during preparation of this paper, it is concluded that the valve Code rules could benefit from a few clarifications; thus, changes are proposed, and the Working Group is encouraged to consider them. In answer to the underlying question regarding the primary local stress category, it is shown that the need for a local stress evaluation would be rare for a valve.
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Lunt, Barry, Joseph Ekstrom, Edith Lawson, Reza Kamali, Jacob Miller, Sandra Gorka, and Han Reichgelt. "Defining the IT Curriculum: The Results of the Past 3 Years." In InSITE 2005: Informing Science + IT Education Conference. Informing Science Institute, 2005. http://dx.doi.org/10.28945/2864.
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Efforts to define IT curriculum and accreditation standards began at the first Conference on Information Technology Curriculum (CITC-1) in December 2001, which included representatives from 15 Information Technology (IT) programs at four-year schools in the United States, and representatives from the Association for Computing Machinery (ACM), the Institute for Electrical and Electronic Engineers (IEEE), and the Accreditation Board for Engineering and Technology (ABET). Since this conference, this work has been ongoing at CITC-2 (April 2002), CITC-3 (September 2002), and CITC-4 (October 2003), and through committee work which has progressed between these conferences. The three main thrusts of this work have been to define standards for accreditation of IT programs, to define a model curriculum for IT programs, and to distinguish IT programs from the most closely-related academic programs, such as Information Systems and Computer Science. Membership in SIGITE (Special Interest Group on Information Technology Education) of the ACM is now over 300 members and represents most 4-year IT programs and several 2-year IT programs in the United States; the outcome of these three main thrusts should therefore be of wide interest to all those in related programs or at institutions considering forming a similar program. This paper gives some of the details of the results of the work on these three thrusts.
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Krishnaswamy, Prabhat, Eric M. Focht, Do-Jun Shim, and Tao Zhang. "Use of Polyethylene (PE) Pipe in Safety-Related, Class 3, Service-Water Piping." In 16th International Conference on Nuclear Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/icone16-48830.
Full textAbstract:
The ASME Boiler and Pressure Vessel Code Committee (BPVC) has recently published Code Case N-755 that describes the requirements for the use of Polyethylene (PE) pipe for the construction of Section III, Division 1 Class 3 buried piping systems for service water applications in nuclear power plants. The code case was developed by Special Working Group–Polyethylene Pipe (SWG-PP) within Section III (Design) of the BPVC. This paper provides a critical review of the design requirements described in CC N-755 from pressure boundary integrity considerations. The various technical issues that need to be addressed for safety-critical PE piping are discussed in this paper. Specifically, the premise of allowing defects in pipe that are 10% of the wall thickness has been reviewed especially for cases involving large diameter piping [> 304.8 mm (12 inches)] that is to be operated at elevated temperatures as high as 60°C (140°F). One of the common modes of failure in PE piping under sustained internal pressure is due to slow crack growth (SCG) from manufacturing or installation defects in the pipe wall. The effect of pipe diameter and stresses on the crack driving force for a 10% deep flaw is calculated for comparison with the material resistance to SCG at elevated temperatures.
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Wen, Jie, Robert Keating, and Timothy M. Adams. "Technical Basis and Strategy for Consolidation of ASME Boiler and Pressure Vessel Code, Section III, Subsection NC (Class 2) and Subsection ND (Class 3) Into a Single Subsection." In ASME 2019 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/pvp2019-93115.
Full textAbstract:
Abstract ASME Boiler Pressure Vessel Code, Section III, Division 1, Subsection NC, Class 2 components, and Subsection ND, Class 3 components, have significant technical and administrative similarities. The ASME BPV III Standards Committee has a long-standing goal of combining these two subsections (NC and ND). Consolidating Subsections NC and ND will simplify, reduce repetitions and make the Code easier to use. Additionally, a combined Subsection NC/ND will simplify Code maintenance. To facilitate this consolidation, the Subgroup on Component Design, under the BPV III Standards Committee assigned a Task Group to develop a strategy to combine the two subsections into a single subsection while maintaining both Class 2 and Class 3 as separate classes of construction. Both Subsections NC and ND of the Code have been completely reviewed, compared and the technical bases for the differences have been established. The conclusion of this review is that there are only a few major technical differences between the two code class rules; however, there are a significant number of editorial differences. Based on the review, the Task Group developed a strategy that completes the consolidation within two publishing cycles of Code edition. For the Code Edition 2019, two separate Subsections NC and ND books will be published to resolve editorial differences and otherwise align the two subsections. For the Code Edition 2021, a single merged subsection will be published. This paper provides the background for the proposed code change, discusses the detailed result of the NC/ND comparison, and provides the basis for the major technical differences. The paper will also update the status of the project and code actions needed to consolidate to a single subsection.
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Métais, Thomas, Stéphan Courtin, Manuela Triay, François Billon, Pascal Duranton, Rudy Briot, Florent Bridier, Cédric Gourdin, and Jean-Pascal Luciani. "An Assessment of the Safety Factors and Uncertainties in the Fatigue Rules of the RCC-M Code Through the Benchmark With the EN-13445-3 Standard." In ASME 2017 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/pvp2017-65397.
Full textAbstract:
The RCC-M code [1] is a well recognized international code and provides rules for the design and the construction of mechanical equipment for pressurized water reactors. It is used today for the nuclear industry exclusively, in countries such as France, South Africa and China and it is the basis for the design of the UK EPR to be built in Hinkley Point. The RCC-M code’s fatigue rules emanate from the ASME Boiler and Pressure Vessel Code and are hence very similar, albeit they have evolved in their own way over time to include some R&D results and other evolutions. These rules are published by AFCEN which involves a wide range of international organizations from the nuclear industry such as Apave, Areva, Bureau Veritas, CEA, DCNS, EDF, EDF Energy, ONET-MHI, Rolls-Royce and Westinghouse. The EN-13445-3 [2] is a European standard which is mostly in use today in the conventional industry. Its fatigue rules are a compilation of rules from various national European codes, such as the German AD-Merkblatt, the British Standards, the Eurocodes for civil works and the French CODAP. The rules for fatigue are compiled in Chapters 17 and 18 of EN-13445-3 and have been the result of the work of contributors from major European organizations from the nuclear, oil and gas, chemical and mechanical industries: these include, among others, Areva, the Linde Group, CETIM, TÜV, and the TWI (The Welding Institute). Since the beginning of 2015, AFCEN has created a technical Working Group (WG) on the topic of fatigue with the objective of identifying the Safety Factors and Uncertainties in Fatigue analyses (SFUF) and of potentially proposing improvements in the existing fatigue rules of the code. Nevertheless, the explicit quantification of safety factors and uncertainties in fatigue is an extremely difficult task to perform for fatigue analyses without a comparison to the operating experience or in relation to another code or standard. Historically, the approach of the code in fatigue has indeed been to add conservatism at each step of the analyses which has resulted in a difficult quantification of the overall safety margin in the analyses. To fulfill its mission, the working group has deemed necessary to lead a benchmark with the EN-13445-3 standard given its wide use through other industries. Two cases were identified: either the comparison with EN-13445-3 is possible and in this case, the identification of safety factors and uncertainties is performed in relation to this standard; either the comparison is not possible, in which case the overall conservatism of the RCC-M code is evaluated in relation with operating experience, test results, literature, etc... This paper aims at describing the overall work of the group and focuses more specifically on the results obtained through the benchmark with the EN-13445-3 standard.
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Cheta, Ayman. "ASME B16 Cases 1 and 2, and Their Implications for ASME B16.34 Valves." In ASME 2016 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/pvp2016-63163.
Full textAbstract:
Similar to ASME Boilers and Pressure Vessel Code Cases, ASME B16 Standards Committee has recently begun to issue B16 Cases to address urgent needs for rules on materials and constructions not covered by existing B16 standards. Case 1[3], approved on December 16, 2013, provides alternative rules for establishing pressure-temperature ratings for ASME B16.34 [1] valves made of Group 3 (high nickel alloys) materials. Case 2[4], approved on February 13, 2014, provides rules for use of unlisted materials for construction of ASME B16.34 valves. In this paper, the author provides an overview of both Cases and discusses their potential implications for ASME B16.34 valves.
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Asayama, Tai, Shigeru Takaya, Masaki Morishita, and Frank Schaaf. "Elaboration of the System Based Code Concept — Activities in JSME and ASME: (4) Joint Efforts of JSME and ASME." In 2014 22nd International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/icone22-30572.
Full textAbstract:
This paper describes the ongoing activities at the Joint Task Group for System Based Code established in 2012 by the Japan Society of Mechanical Engineers (JSME) and the American Society of Mechanical Engineers (ASME) in the ASME Boiler and Pressure Vessel Code Committee. The Joint Task Group aims at developing alternative rules for ASME Boiler and Pressure Vessel Code Section XI Division 3, inservice inspection requirements for liquid metal reactors. The alternative rules will be developed based on the System Based Code concept which was originally proposed in Japan and is being elaborated both in JSME and ASME. The alternative rules are for sodium-cooled fast reactors where some of the components could have difficulties in conforming to the current requirements primarily due to accessibility. The alternative requirements would consist of a set of relieved requirements and a logic flow through which the applicability of them is judged. The logic flow considers both component structural integrity and the plant safety goals. The issuance of a Code Case is envisioned around 2016. Further efforts to integrate the process into a new framework being developed in Section XI would cover various types of reactors.
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Declercq, Cedric, Andrew Ballard, Giovanni Ferraro, and Anicet Touré. "The EUR Assessment Process and Highlights of the Compliance Analysis for the EU-APR Standard Design." In 2018 26th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icone26-81889.
Full textAbstract:
The EU-APR standard design is a two-loop pressurised water reactor of the range of 1400MWe, developed by Korean Hydro & Nuclear Power (KHNP) from the Korean APR1400 reference plant. It is the objective of the EU-APR to comply with the current main European regulatory and utility requirements for safe and competitive LWR NPPs. A full assessment of the EU-APR against the European Utility Requirements (EUR) can therefore be regarded as an important step in its introduction to the European market. KHNP’s request to assess its EU-APR standard design was granted by the EUR Organisation and in autumn of 2015, a two-year assessment process started, during which the EU-APR was assessed against the twenty chapters of the EUR Document Volume 2, encompassing over four thousand individual requirements having in view principally NPP safety and performance. The EU-APR standard design was assessed against each single requirement by experts of the appropriate discipline from within the EUR member companies. The resultant assessment reports were reviewed by the Coordination Group (working level team) and then validated by the EUR Administration Group and EUR Steering Committee. The syntheses of the requirement-by-requirement assessments per chapter were collected in the principal project output: the EU-APR dedicated subset of EUR Document Volume 3. This Volume 3 subset (Subset I) also contains a technical description of the plant, issued by KHNP and reviewed by the EUR organisation. Furthermore, it explains the assessment process and highlights the main assessment results. Volume 3 Subset I was approved by the EUR Steering Committee in September 2017. The EU-APR standard design was found to be fully compliant for a majority (almost 90%) of all requirements applicable in this assessment. Furthermore, the EU-APR was found to be compliant with the objectives of an additional 6% of the investigated requirements. The EU-APR standard design can be considered to be in the late basic design phase. Nonetheless, the portion of requirements which were not assessable is very low (below 3%), explained by the abundant availability of reference plant (detailed design) documentation, which often helped demonstrate by means of extrapolatable examples KHNP’s adherence to design principles established for the EU-APR. In total, less than 1% of assessed requirements were found to be non-compliant. The main non-compliances relate to choices of design principles and analysis methods that are explicitly different from those stipulated by EUR, and to the relatively low level of development of reactor core and fuel studies to demonstrate operational nuclear plant manoeuvrability and fuel cycle optimisation in view of safety margins and economics.
Reports on the topic "Africa (Group 3) Committee"
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Merrill, Albert W., Matthew A. Clark, James Hoffman, Gary L. Gallien, Thomas M. Walsh, Dave Y. Stodden, Sarah A. Lang, and Ragini T. Joshi. Commerce Spectrum Management Advisory Committee (CSMAC) Working Group (WG) 3 Phase 2 Study Summary. Fort Belvoir, VA: Defense Technical Information Center, May 2013. http://dx.doi.org/10.21236/ada590005.
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