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Dissertations / Theses on the topic 'Age-related macular degeneration'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Gu, Jiayin. "Biomarkers for Age-Related Macular Degeneration." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1225388164.

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2

Renganathan, Kutralanathan. "Oxidative stress and age related macular degeneration." online version, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1193002743.

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3

Binns, Alison Mary. "Electrophysiological investigation of age-related macular degeneration." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/55964/.

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Age-related macular degeneration (AMD) affects 12.7 million people in Europe and North America (Klein et al., 1995 Klein et al. 1999). As a combination of decreasing birth rate and increasing longevity alter the demographic of the population, the impact of this disease can only increase. This places an immense burden, not only on the individuals afflicted by the condition, but on the financial resources of society as a whole. Unfortunately, treatment for AMD is still very restricted, and even our understanding of the pathogenesis of the disease is far from complete One concern in tackling the

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4

Evans, Jennifer Rosemary. "Age-related macular degeneration in the UK." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2003. http://researchonline.lshtm.ac.uk/682315/.

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The aim of this thesis was to investigate the prevalence and impact of age-related macular degeneration (AMD) causing visual impairment in people aged 75 years and above in the UK. A secondary objective was to investigate a small number of potential risk factors for AMD. This was an add-on study to the MRC Trial of the Assessment and Management of Older People in the Community. The prevalence of AMD causing visual impairment was estimated at 3.7% (95% confidence interval 3.2% to 4.2%) in people aged 75 years and above. This prevalence increased sharply with age. There was a higher risk of AMD

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5

Goverdhan, Srinivas. "Immunogenetic pathways in age related macular degeneration." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/66006/.

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6

Renganathan, Kutralanathan. "Oxidative Damage and Age Related Macular Degeneration." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1193002743.

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7

Wang, Yang. "Gene Discovery for Age-related Macular Degeneration." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1228364622.

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8

NI, JIAQIAN. "Plasma Biomarkers for Age-Related Macular Degeneration." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1236700270.

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9

Wu, Juan. "Dietary Determinants of Age-Related Macular Degeneration." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:27201715.

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Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in older Americans. There has been a long standing interest in the role of diet in the development of AMD. As early as the first National Health and Nutrition Examination Survey in the 1970s, higher intakes of fruits and vegetables were inversely correlated with the prevalence of AMD. Carotenoids and omega3 fatty acids are the most studied dietary factors due to strong biological plausibility. However, evidence from epidemiologic studies and clinical trials on the relations has been inconsistent. Chapter

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10

Wang, Yang. "Gene discovery of age-related macular degeneration." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1228364622.

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11

Hemphill, Mandy. "Vitamin D and Age-Related Macular Degeneration." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3448.

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Age-related macular degeneration (AMD) is the leading cause of vision loss in individuals aged 50 years and older and is estimated to affect as many as 11 million individuals in the United States. The purpose of this study was to examine the association between vitamin D and AMD disease progression. The life course epidemiology framework model was used to explore how vitamin D level as a risk factor may have an association to AMD disease through time. Data in the 2005-2008 National Health and Nutrition Examination Survey (NHANES) database were collected on vitamin D levels and identified stage

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12

Whitmore, Steven Scott. "Molecular investigations of age-related macular degeneration." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1798.

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An estimated 170.38 million elderly adults suffer from some stage of age-related macular degeneration (AMD) worldwide, a vision defect that damages the macula, the central region of the retina required for sharp vision, such as reading, driving, and recognizing faces. Genetic factors strongly modify one's risk for developing AMD, and most of these genetic changes are found in genes of the alternative complement cascade, a component of the immune system. The lack of effective AMD prevention calls for the identification of druggable molecules and pathways. In my research, I use microarrays and R

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13

E, Caldi. "Age related macular degeneration: a molecular insight." Doctoral thesis, Università di Siena, 2018. http://hdl.handle.net/11365/1060781.

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Age-related macular degeneration (AMD) is a progressive and degenerative disease affecting the macula lutea. Late stages include neovascular AMD (nAMD), which represents the most severe form of the disease and is characterized by the abnormal growth of newly formed blood vessels from the pre-existing choroidal vessels. Neovascularization breaks through Bruchʼs membrane reaching the retina where bleeding, fluids extravasation and a chronic inflammatory reaction eventually cause severe vision loss, up to blindness if left untreated. With the aim to better elucidate the neoangiogenic process und

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14

Gaffney, Allannah J. "Characterising adaptational dysfunction in age-related macular degeneration." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/41072/.

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Age-related macular degeneration (AMD) is the leading cause of visual impairment in the developed world. The prevalence of this disease will continue to increase over the coming decades as the average age of the global population rises. There is consequently an urgent need to develop tests that are sensitive to early visual dysfunction, in order to identify individuals that have a high risk of developing AMD, to identify patients that would benefit from treatment, to assess the outcomes of that treatment and to evaluate emerging treatment strategies. An emerging body of evidence suggests that

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15

Pushpoth, Sreekumari. "Use of metabolomics in age-related macular degeneration." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8371/.

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Age-related macular degeneration (AMD) is a major cause of irreversible central sight loss in the elderly. Many factors affect disease onset and progression, and these include age, environmental stressors such as smoking, diet, inflammation and genetic polymorphisms, all of which are likely to influence metabolism. In some complex diseases, metabolomics, which involves the identification of a metabolic fingerprint in a biofluid or tissue, has been shown to discriminate metabolic changes associated with different disease processes and to identify specific phenotypes. We have applied metabolomic

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16

Dandekar, Samantha Sujata. "Detailed clinical phenotyping in Age-related Macular Degeneration." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444668/.

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Age-related Macular Degeneration (AMD) is a degenerative disorder that accounts for about 50% of blindness in England and Wales. At present there is no effective treatment. It occurs in genetically susceptible individuals exposed to environmental factors such as smoking but so far specific factors remain to be identified. For this descriptive study, 879 patients with Age-Related Maculopathy (ARM) and AMD and 44 spouses with normal maculae, to act as a comparison group, were recruited from a tertiary referral centre. The clinical phenotypes were analysed from fundus photographs, fluorescein ang

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17

Anderson, O. A. "Age-related macular degeneration : pathogenesis and drug delivery." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1457066/.

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Age related macular degeneration (AMD) is the leading cause of blindness amongst the elderly in the developed world. There is currently no effective treatment for the atrophic (dry) form of the disease. The aims of this thesis are twofold: Firstly to investigate the pathogenesis of atrophic AMD, a chronic inflammatory disease, with a view to identifying new potential treatment targets. Secondly to develop a novel method of sustained drug delivery with a view to using this mode of delivery to deliver immune modulating therapy in the treatment of atrophic AMD. We discovered that A2E, the major f

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18

Lo, David. "Effects of combination therapies on age-related macular degeneration." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21209.

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Thesis (M.A.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Age-related macular degeneration (AMD) is the most common cause of vision loss in America for people over the age of 60. Due to damage to the retina, symptoms normally include blurred central vision, difficulty reading, and seeing

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Cherepanoff, Svetlana. "Age-related macular degeneration histopathological and serum autoantibody studies /." Connect to full text, 2007. http://hdl.handle.net/2123/2464.

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Thesis (Ph. D.)--University of Sydney, 2008.<br>Title from title screen (viewed 18 June 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Clinical Ophthalmology and Eye Health, Faculty of Medicine. Degree awarded 2008; thesis submitted 2007. Includes bibliographical references. Also available in print form.

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Cherepanoff, Svetlana. "Age-related macular degeneration: histopathological and serum autoantibody studies." University of Sydney, 2008. http://hdl.handle.net/2123/2464.

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Doctor of Philosophy (PhD)<br>BACKGROUND: The accumulation of abnormal extracellular deposits beneath the retinal pigment epithelium characterises the pathology of early age-related macular degeneration. However, the histopathological threshold at which age-related changes become early AMD is not defined, and the effect of each of the deposits (basal laminar deposit and membranous debris) on disease progression is poorly understood. Evidence suggests that macrophages play a key role in the development of AMD lesions, but the influence of basal laminar deposit (BLamD) and membranous debris on t

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21

Walsh, Rachel. "Optimising dietary modification for age-related macular degeneration (AMD)." Thesis, Aston University, 2018. http://publications.aston.ac.uk/33417/.

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An ageing population has raised the priority of reducing the risk for age-related eye diseases that impair sight and quality of life. Chief among these diseases is age- related macular degeneration (AMD), the leading cause of visual impairment among older adults in the developed world. The dietary xanthophylls lutein and zeaxanthin may be effective at attenuating the risk and/or progression of AMD due to their antioxidant and photo-protective properties in the macula, where they are known as the macular pigment. The macular pigment is entirely of dietary origin therefore it is important that A

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22

Kambanarou, Stamatina. "Binocular versus monocular viewing in age-related macular degeneration." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445617/.

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Purpose: This thesis compares monocular versus binocular viewing in AMD patients during fixation and reading, the potential of binocular function and the impact of symmetry of central scotomas on these results. Methods: Thirty patients with bilateral AMD were recruited. Standard clinical tests (distance and near acuity, contrast sensitivity, stereoacuity) were performed monocularly and binocularly. Fusion at the fixation locus was tested with a computer-driven display using shutter glasses. A scanning laser ophthalmoscope was used to map the preferred retinal locus (PRL) and the retinal scotom

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23

Callaghan, Tamsin. "Functional biomarkers of hypoxia in age-related macular degeneration." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/97168/.

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Age-related macular degeneration (AMD) is predicted to affect 196 million people by 2020 (Wong et al. 2014). To date there is no clear pathogenesis for the condition however, hypoxia has been implicated (Stefánsson et al. 2011). Currently, treatment is only available for neovascular AMD. To develop treatments targeted for early AMD a better understanding of the pathogenesis is required. There is also a need for sensitive functional biomarkers to improve diagnosis and monitoring and to expedite the evaluation of therauptics in clinical trials. The aim of this research was to investigate the hyp

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24

Cherepanoff, Svetlana. "Age-related macular degeneration: histopathological and serum autoantibody studies." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/2464.

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BACKGROUND: The accumulation of abnormal extracellular deposits beneath the retinal pigment epithelium characterises the pathology of early age-related macular degeneration. However, the histopathological threshold at which age-related changes become early AMD is not defined, and the effect of each of the deposits (basal laminar deposit and membranous debris) on disease progression is poorly understood. Evidence suggests that macrophages play a key role in the development of AMD lesions, but the influence of basal laminar deposit (BLamD) and membranous debris on the recruitment and programming

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25

Skeie, Jessica Marie. "Choroidal endothelial cell activation in age-related macular degeneration." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/602.

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Age-related macular degeneration (AMD) is a devastating ocular disease affecting one third of the elderly population in the western world. Some cases of AMD develop neovascular membranes, which are characterized by the pathologic growth of new blood vessels into the retina. This pathology may be initiated by proteins capable of activating endothelial cells to become angiogenic or inflammatory, later causing them to grow abnormally. This investigation aimed to determine the causes of pathologic blood vessel growth in AMD. Human eyes with AMD have been shown by us and others to have abnormal act

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26

Narvekar, Priya P. "Axitinib Loaded PLGA nanoparticles for Age-Related Macular Degeneration." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7866.

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Despite of all the research going on for the treatment of ocular diseases, age-related macular degeneration (AMD) remains one of the serious vision threatening disease worldwide. Choroidal neovascularization, a pathophysiological characteristic of wet AMD, is the growth of anomalous blood vessels in the eye choroidal layer. Neovascularization is a key factor in AMD and thus anti-angiogenic therapy is beneficial in reducing the development of new abnormal blood vessels to prevent progression of AMD. Axitinib, multi-receptor tyrosine kinase inhib

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27

Kopplin, Laura J. "The indentification of genetic risk factors for age-related macular degeneration." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1251752708.

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28

Burton, Amy. "The experience of living with age related macular degeneration : a longitudinal study into the impact of age related macular degeneration on quality of life." Thesis, Aston University, 2013. http://publications.aston.ac.uk/19020/.

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In this thesis I contribute to the understanding of the experience of living with Age-Related Macular Degeneration (AMD) and its impact on quality of life through the use of a pragmatically guided mixed methods approach. AMD is a condition resulting in the loss of central vision in old age which can have a huge impact on the lives of patients. This thesis includes: literature reviewing; qualitative meta-synthesis; surveys and descriptive statistics; observation; and analysis of in-depth interviewing, in order to build a picture of what it is like for older people to live with AMD. I present th

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29

Cao, Sijia. "The role of complement activation in age-related macular degeneration." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58666.

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Purpose: Age-related macular degeneration (AMD) is a multifactorial degenerative disease that occurs in the central part of the retina − macula. The disease affects approximately one million Canadians and constitutes the number one cause of vision loss after cataract in the elderly. The Y402H polymorphism in the complement factor H (CFH) gene and drusen load are two salient risk factors for AMD. Little is known of the detailed cellular pathway(s) shared by these two factors. Here we investigate their interactions in in vitro models of AMD and in AMD samples. Methods: The biological samples

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30

Muldrew, K. A. "The enigma of visual function in age-related macular degeneration." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420929.

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31

Gilchrist, S. E. C. M. "Nutritional determinants of cardiovascular and age-related macular degeneration risk." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438633.

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32

Butt, T. J. "Valuation of health states associated with age-related macular degeneration." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1471706/.

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Economic evaluation of health technology using cost-utility analysis (CUA) normally applies an extra-welfarist framework in which health, the unit of effectiveness, is maximised. Typically, health status is measured by health-related quality of life (HRQoL) questionnaires to define health states. Preferences for health states are valued on a utility scale and combined with the time spent in the state to calculate quality-adjusted life years (QALYs). This thesis develops methods for measuring and valuing health using the case of age-related macular degeneration (AMD), where there are limitation

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33

Heller, Janosch Peter Dave. "Transplantation of retinal pigment epithelium in age-related macular degeneration." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708198.

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34

Khandhadia, Samir. "Age-related macular degeneration, complement Factor H and liver transplantation." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/375260/.

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35

Kar, Taner, Yildiray Yildirim, Aytuğ Altundağ, et al. "The Relationship between Age-Related Macular Degeneration and Olfactory Function." Karger, 2015. https://tud.qucosa.de/id/qucosa%3A70587.

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Background: Olfactory dysfunction is a common symptom of many neurodegenerative diseases, and age-related macular degeneration (AMD) is a late-onset neurodegenerative disease. Objective: Thus, the aim of this study was to investigate olfactory functions in patients with AMD. Methods: A total of 69 subjects with AMD and 69 age- and sex-matched healthy controls were enrolled. After a complete ophthalmic evaluation, the AMD patients were subclassified as earlyand late-stage AMD. Psychophysical testing of olfactory function was performed using the validated Sniffin’ Sticks test. Results: This stud

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36

Acton, Jennifer H. "Visual field and structural alterations in age-related macular degeneration." Thesis, Aston University, 2010. http://publications.aston.ac.uk/8821/.

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The thesis investigated progression of the central 10° visual field with structural changes at the macula in a cross-section of patients with varying degrees of agerelated macular degeneration (AMD). The relationships between structure and function were investigated for both standard and short-wavelength automated perimetry (SWAP). Factors known to influence the measure of visual field progression were considered, including the accuracy of the refractive correction on SWAP thresholds and the learning effect. Techniques of assessing the structure to function relationships between fundus images

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37

Ahmad, Hijazi Mohd Hanafi. "Image classification : a study in age-related macular degeneration screening." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/7093/.

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This thesis presents research work conducted in the field of image mining. More specifically, the work is directed at the employment of image classification techniques to classify images where features of interest are very difficult to distinguish. In this context, three distinct approaches to image classification are proposed. The first is founded on a time series based image representation, whereby each image is defined in terms of histograms that in turn are presented as "time series" curves. A Case Based Reasoning (CBR) mechanism, coupled with a Time Series Analysis (TSA) technique, is the

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38

Allen, Cynthia. "Egg consumption and age-related macular degeneration : a pilot study /." Search for this dissertation online, 2004. http://wwwlib.umi.com/cr/ksu/main.

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39

Constable, Ian Jeffrey. "Development of Gene Therapy for Age-related Exudative Macular Degeneration." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24032.

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Age-related macular degeneration (AMD) became the commonest cause of legal blindness in developed countries by 1990, compounded by the ageing of the population, the absence of any useful therapy and a dearth of knowledge as to the molecular biological underlying abnormalities. The publications embodied in this thesis extend over the following 28 years and contribute original knowledge by way of laboratory experimentation into the pathogenesis and then novel animal and human clinical trials. The programme lead to international pharmaceutical development of unique viral gene therapy for AMD. Tis

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40

Augood, Cristina. "Association of polyunsaturated fatty acids with age-related macular degeneration." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536759.

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41

Nau, Jeffrey A. "Association Between Age-Related Macular Degeneration and Sleep-Disordered Breathing." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3463.

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Age-related macular degeneration (AMD) is a chronic, irreversible disease that robs individuals of vision, quality of life, and independence. It is the leading cause of blindness in industrialized countries. Sleep-disordered breathing (SDB) is a condition characterized by repeated episodes of apnea and/or hypopnea, insomnia, short sleep duration, and/or sleep disturbances (snoring, gasping, etc.). Because SDB has been shown to cause chronic hypoxia resulting in oxidative stress on the retina, it has been proposed that SDB may be associated with AMD. Based on the life course theory of chronic d

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42

White, Ursula. "Concern about falling in people with age-related macular degeneration." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/201804/1/Ursula_White_Thesis.pdf.

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Concern about falling (CF) is a significant health issue among older people, leading to activity restriction, physical decline, and increased falls risk. Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss among older people, yet little is known about CF in this population. High levels of CF were demonstrated among those with AMD, predicted by reduced visual function, and other physical and psychological factors. Over a 12-month period, CF increased, more so than in general older populations. These results provide an important basis for developing interventi

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43

Kopplin, Laura J. "The Identification of Genetic Risk Factors for Age-Related Macular Degeneration." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1251752708.

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44

Tang, Diana. "Closing the Evidence-Practice Gap: Nutrition and Age-related Macular Degeneration." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25105.

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Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries. Despite evidence supporting dietary modification to reduce the risk of AMD development and progression an evidence-practice gap exists as people with AMD are not adhering to the recommendations reported in research literature. In an attempt to close this gap, this thesis describes three research studies: study one aims to evaluate the use of a novel tool (SDQ-AMD) to screen inadequate food intake in people with AMD; study two aims to evaluate the effectiveness of a telephone-delivered dietary interve

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Stanton, Chloe May. "Investigating the genetic and molecular basis of age-related macular degeneration." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9608.

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Age-related macular degeneration (AMD) is the leading cause of blindness worldwide, affecting an estimated 50 million individuals aged over 65 years. Environmental and genetic risk-factors contribute to the development of AMD. An AMD-risk locus on chromosome 10q26 spans two genes, ARMS2 and HTRA1, and controversy exists as to which variants are responsible for increased risk of disease. Recent work suggests that HTRA1 expression levels are significantly increased in carriers of the risk haplotype associated with AMD. However, relatively little is known about the interactions, substrate specifi

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Broadhead, Geoffrey Kenneth. "Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14720.

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Purpose: To assess the efficacy of two therapies, intravitreal aflibercept and oral saffron supplementation, for the treatment of different aspects of age-related macular degeneration (AMD). Methods: Two prospective clinical trials were conducted, i) one open label, single arm trial investigating intravitreal aflibercept for the management of treatment-resistant neovascular AMD, and ii) the other a randomised control trial investigating oral saffron supplementation for the treatment of intermediate AMD. Outcomes assessed included: mean change in mfERG response, mean change in individual mfERG

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Deffler, Rebecca Ann. "Socioeconomic factors related to visual outcomes in patients with age-related macular degeneration." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555523090849182.

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48

Reeves, John A. F. "Longitudinal regression models for a study of age-related macular degeneration." Thesis, Keele University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267456.

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49

Cassels, Nicola. "Quality-of-life and clinical outcomes in age-related macular degeneration." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/109189/.

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Age-related macular degeneration (AMD) is of increasing concern given the ageing population, and the associated economic and social burdens. Vision-related quality-of-life (QoL) is arguably one of the most important factors in the management of those with AMD. Consequently, there is a clear need for an understanding of the clinical outcomes that influence vision-related QoL in order to inform management strategies. The principle aim of the studies described herein was to determine the factors that predict vision-related QoL in those with AMD, over 1 year. Experimental procedures were undertake

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Gates, D. P. "An investigation into the inflammatory axis of age-related macular degeneration." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501264.

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