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Journal articles on the topic 'Ageing Clock'

Author: Grafiati

Published: 23 August 2023

Last updated: 31 July 2025

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1

Guevara, Elaine E., Richard R. Lawler, Nicky Staes, et al. "Age-associated epigenetic change in chimpanzees and humans." Philosophical Transactions of the Royal Society B: Biological Sciences 375, no. 1811 (2020): 20190616. http://dx.doi.org/10.1098/rstb.2019.0616.

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Methylation levels have been shown to change with age at sites across the human genome. Change at some of these sites is so consistent across individuals that it can be used as an ‘epigenetic clock’ to predict an individual's chronological age to within a few years. Here, we examined how the pattern of epigenetic ageing in chimpanzees compares with humans. We profiled genome-wide blood methylation levels by microarray for 113 samples from 83 chimpanzees aged 1–58 years (26 chimpanzees were sampled at multiple ages during their lifespan). Many sites (greater than 65 000) showed significant chan

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2

O’Brien, Yvonne, and Mary B. Wingfield. "Reproductive ageing—turning back the clock?" Irish Journal of Medical Science (1971 -) 188, no. 1 (2018): 161–67. http://dx.doi.org/10.1007/s11845-018-1769-2.

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3

Gibbs, W. Wayt. "Biomarkers and ageing: The clock-watcher." Nature 508, no. 7495 (2014): 168–70. http://dx.doi.org/10.1038/508168a.

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AGRELL, BERIT, and OVE DEHLIN. "The clock-drawing test." Age and Ageing 27, no. 3 (1998): 399–403. http://dx.doi.org/10.1093/ageing/27.3.399.

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5

Agrell, B., and O. Dehlin. "The clock-drawing test." Age and Ageing 41, suppl 3 (2012): iii41—iii45. http://dx.doi.org/10.1093/ageing/afs149.

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6

Halmos, Tamás, and Ilona Suba. "Physiological and pathophysiological role of the circadian clock system." Orvosi Hetilap 153, no. 35 (2012): 1370–79. http://dx.doi.org/10.1556/oh.2012.29436.

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It has been well known for ages that in living organisms the rhythmicity of biological processes is linked to the ~ 24-hour light–dark cycle. However, the exact function of the circadian clock system has been explored only in the past decades. It came to light that the photosensitive primary “master clock” is situated in the suprachiasmatic photosensitive nuclei of the special hypothalamic region, and that it is working according to ~24-hour changes of light and darkness. The master clock sends its messages to the peripheral “slave clocks”. In many organs, like pancreatic β-cells, the slave cl

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El-Houni, Zeyad, Alexander Eckersley, Mike Bell, et al. "P12 Tetrapeptide matrikines synchronize circadian rhythms and promote proliferation in human skin cells." British Journal of Dermatology 189, no. 1 (2023): e18-e18. http://dx.doi.org/10.1093/bjd/ljad174.033.

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Abstract Circadian rhythms are intrinsically generated 24 h rhythms that play a vital role in enabling the skin to adapt temporally to various external stimuli. These include ultraviolet radiation, physical trauma and water loss. At the molecular level, circadian clocks consist of various clock genes and proteins, including Per2/Cry1 and Bmal1/Clock, forming autoregulatory feedback loops. Although these rhythms are known to be impaired in ageing skin, there are limited therapeutic options to restore skin cell circadian function. As small peptides with homology to amino acid sequences found in

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Raj, Kenneth, and Steve Horvath. "Current perspectives on the cellular and molecular features of epigenetic ageing." Experimental Biology and Medicine 245, no. 17 (2020): 1532–42. http://dx.doi.org/10.1177/1535370220918329.

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It has been noted for quite some time that DNA methylation levels decline with age. The significance of this change remained unknown until it became possible to measure methylation status of specific sites on the DNA. It was observed that while the methylation of some sites does indeed decrease with age, that of others increase or remain unchanged. The application of machine learning methods to these quantitative changes in multiple sites, allowed the generation of a highly accurate estimator of age, called the epigenetic clock. The application of this clock on large human epidemiological data

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9

FRIEDMAN, PAUL J. "Clock Drawing in Acute Stroke." Age and Ageing 20, no. 2 (1991): 140–45. http://dx.doi.org/10.1093/ageing/20.2.140.

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10

Liu, Zuyun, and Yimin Zhu. "Epigenetic clock: a promising mirror of ageing." Lancet Healthy Longevity 2, no. 6 (2021): e304-e305. http://dx.doi.org/10.1016/s2666-7568(21)00098-2.

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Kloeden, P. E., R. Rössler, and O. E. Rössler. "Does a Centralized Clock for Ageing Exist?" Gerontology 36, no. 5-6 (1990): 314–22. http://dx.doi.org/10.1159/000213216.

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12

Zaina, Silvio, Manel Esteller, Isabel Gonçalves, and Gertrud Lund. "Dynamic epigenetic age mosaicism in the human atherosclerotic artery." PLOS ONE 17, no. 6 (2022): e0269501. http://dx.doi.org/10.1371/journal.pone.0269501.

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Accelerated epigenetic ageing, a promising marker of disease risk, has been detected in peripheral blood cells of atherosclerotic patients, but evidence in the vascular wall is lacking. Understanding the trends of epigenetic ageing in the atheroma may provide insights into mechanisms of atherogenesis or identify targets for molecular therapy. We surveyed DNA methylation age in two human artery samples: a set of donor-matched, paired atherosclerotic and healthy aortic portions, and a set of carotid artery atheromas. The well-characterized pan-tissue Horvath epigenetic clock was used, together w

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13

Colombini, Barbara, Monica Dinu, Emanuele Murgo, et al. "Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock." Antioxidants 11, no. 11 (2022): 2228. http://dx.doi.org/10.3390/antiox11112228.

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Ageing is a multifactorial physiological manifestation that occurs inexorably and gradually in all forms of life. This process is linked to the decay of homeostasis due to the progressive decrease in the reparative and regenerative capacity of tissues and organs, with reduced physiological reserve in response to stress. Ageing is closely related to oxidative damage and involves immunosenescence and tissue impairment or metabolic imbalances that trigger inflammation and inflammasome formation. One of the main ageing-related alterations is the dysregulation of the immune response, which results

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Wijaya, Joan C., Ramin Khanabdali, Harry M. Georgiou, and Bill Kalionis. "Ageing in human parturition: impetus of the gestation clock in the decidua†." Biology of Reproduction 103, no. 4 (2020): 695–710. http://dx.doi.org/10.1093/biolre/ioaa113.

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Abstract Despite sharing many common features, the relationship between ageing and parturition remains poorly understood. The decidua is a specialized lining of endometrial tissue, which develops in preparation for pregnancy. The structure and location of the decidua support its role as the physical scaffold for the growing embryo and placenta, and thus, it is vital to sustain pregnancy. Approaching term, the physical support properties of the decidua are naturally weakened to permit parturition. In this review, we hypothesize that the natural weakening of decidual tissue at parturition is pro

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15

Collins, Christopher, James Brown, and Henry C. Chung. "A Cost-Effective Saliva-Based Human Epigenetic Clock Using 10 CpG Sites Identified with the Illumina EPIC 850k Array." DNA 5, no. 2 (2025): 28. https://doi.org/10.3390/dna5020028.

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Background/Objectives: DNA methylation profiles have emerged as robust biomarkers of ageing, leading to the development of “epigenetic clocks” that estimate biological age. Most established clocks (e.g., Horvath’s 353-CpG pan-tissue clock and Hannum’s 71-CpG blood clock) require dozens to hundreds of CpG sites. This study presents a novel saliva-specific epigenetic clock built on 10 sites identified from Illumina MethylationEPIC (850 k) array data. Methods: Saliva DNA methylation was analysed from 3408 individuals (age range 15–89 years, 68% male, 32% female, no diagnosed disease) from the Muh

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Adams, D. D., W. O. Lucas, B. G. Williams, B. B. Berkeley, K. W. Turner, and J. C. Schofield. "A mouse genetic locus with death clock and life clock features." Mechanisms of Ageing and Development 122, no. 2 (2001): 173–89. http://dx.doi.org/10.1016/s0047-6374(00)00230-x.

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17

Lowe, Donna, Steve Horvath, and Kenneth Raj. "Epigenetic clock analyses of cellular senescence and ageing." Oncotarget 7, no. 8 (2016): 8524–31. http://dx.doi.org/10.18632/oncotarget.7383.

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18

van Hout, H. "Inter-rater reliability of the clock-drawing test." Age and Ageing 28, no. 3 (1999): 327–28. http://dx.doi.org/10.1093/ageing/28.3.327.

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19

Hoylaerts, Marc F. "Animal Models of Aging Research." Blood 126, no. 23 (2015): SCI—4—SCI—4. http://dx.doi.org/10.1182/blood.v126.23.sci-4.sci-4.

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Ageing is associated with increased hypercoagulability, due to a slow rise of several coagulation factors, factor VIII, fibrinogen and thrombin-antithrombin complexes, markers of fibrinolysis and progressively defective Protein C activation, yet compatible with life at very high age. Mice, naturally aged up to 24 months, likewise show a progressive elevation of coagulation factors, triggering enhanced thrombogenicity during acute injury-induced thrombus formation. To overcome the still gradual natural ageing in mice, several mouse models of premature ageing were characterized, in an effort to

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20

Biemans, Ynte, Daimy Bach, Pariya Behrouzi, et al. "Identifying the relation between food groups and biological ageing: a data-driven approach." Age and Ageing 53, Supplement_2 (2024): ii20—ii29. http://dx.doi.org/10.1093/ageing/afae038.

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Abstract Background Heterogeneity in ageing rates drives the need for research into lifestyle secrets of successful agers. Biological age, predicted by epigenetic clocks, has been shown to be a more reliable measure of ageing than chronological age. Dietary habits are known to affect the ageing process. However, much remains to be learnt about specific dietary habits that may directly affect the biological process of ageing. Objective To identify food groups that are directly related to biological ageing, using Copula Graphical Models. Methods We performed a preregistered analysis of 3,990 pos

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21

Kondratova, Anna A., and Roman V. Kondratov. "The circadian clock and pathology of the ageing brain." Nature Reviews Neuroscience 13, no. 5 (2012): 325–35. http://dx.doi.org/10.1038/nrn3208.

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22

Vetter, Valentin, Kamil Demircan, Jan Homann, et al. "ACCELERATED PACE OF BIOLOGICAL AGING IN PARTICIPANTS WITH LOW LEVELS OF SELENIUM BIOMARKERS IN BERLIN AGING STUDY II." Innovation in Aging 8, Supplement_1 (2024): 806–7. https://doi.org/10.1093/geroni/igae098.2617.

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Abstract Low levels of selenium in blood were shown to be associated with adverse health outcomes and are discussed as anti-aging interventions by some investigators. Inter-individual differences in the aging process can be quantified by epigenetic clocks (DNA methylation age, DNAmA). In this study, we analyzed 1,568 participants of the Berlin Aging Study II (BASE-II, mean age +/- SD: 68.8 +/- 3.7 years, 51% women). DNAmA, and its deviation from chronological age, DNAmA acceleration (DNAmAA), were measured from DNA methylation data derived from Illumina’s “MethylationEPIC” array via the Horvat

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23

Froy, O. "Circadian rhythms, nutrition and implications for longevity in urban environments." Proceedings of the Nutrition Society 77, no. 3 (2017): 216–22. http://dx.doi.org/10.1017/s0029665117003962.

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Presently, about 12% of the population is 65 years or older and by the year 2030 that figure is expected to reach 21%. In order to promote the well-being of the elderly and to reduce the costs associated with health care demands, increased longevity should be accompanied by ageing attenuation. Energy restriction, which limits the amount of energy consumed to 60–70% of the daily intake, and intermittent fasting, which allows the food to be available ad libitum every other day, extend the life span of mammals and prevent or delay the onset of major age-related diseases, such as cancer, diabetes

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24

Pierpaoli, W., and V. Lesnikov. "Theoretical Considerations on the Nature of the Pineal ‘Ageing Clock’." Gerontology 43, no. 1-2 (1997): 20–25. http://dx.doi.org/10.1159/000213833.

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25

Duggal, Niharika A. "Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions." Biogerontology 19, no. 6 (2018): 481–96. http://dx.doi.org/10.1007/s10522-018-9771-7.

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Dallimore, B., B. Bhowmick, J. Meara, and P. Hobson. "Clock Drawing in Elderly Stroke Patients." Age and Ageing 26, suppl 3 (1997): P14. http://dx.doi.org/10.1093/ageing/26.suppl_3.p14-c.

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27

ŁASZKIEWICZ, A., S. CEBRAT, and D. STAUFFER. "SCALING EFFECTS IN THE PENNA AGEING MODEL." Advances in Complex Systems 08, no. 01 (2005): 7–14. http://dx.doi.org/10.1142/s0219525905000294.

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We have analyzed the possibility of scaling the sexual Penna ageing model. Assuming that the number of genes expressed before the reproduction age grows linearly with the genome size and that the mutation rate per genome and generation is constant, we have found that the fraction of defective genes expressed before the minimum reproduction age drops with the genome size, while the number of defective genes eliminated by the genetic death grows with genome size. Thus, the evolutionary costs decrease with increasing genome size. After rescaling the time scale according to the mutational clock, a

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Vitale, Jacopo, Matteo Bonato, Antonio La Torre, and Giuseppe Banfi. "The Role of the Molecular Clock in Promoting Skeletal Muscle Growth and Protecting against Sarcopenia." International Journal of Molecular Sciences 20, no. 17 (2019): 4318. http://dx.doi.org/10.3390/ijms20174318.

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The circadian clock has a critical role in many physiological functions of skeletal muscle and is essential to fully understand the precise underlying mechanisms involved in these complex interactions. The importance of circadian expression for structure, function and metabolism of skeletal muscle is clear when observing the muscle phenotype in models of molecular clock disruption. Presently, the maintenance of circadian rhythms is emerging as an important new factor in human health, with disruptions linked to ageing, as well as to the development of many chronic diseases, including sarcopenia

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He, Lingxiao. "Epigenetic Clock: A Novel Tool for Nutrition Studies of Healthy Ageing." Journal of nutrition, health & aging 26, no. 4 (2022): 316–17. http://dx.doi.org/10.1007/s12603-022-1773-0.

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30

Horvath, Steve, and Kenneth Raj. "DNA methylation-based biomarkers and the epigenetic clock theory of ageing." Nature Reviews Genetics 19, no. 6 (2018): 371–84. http://dx.doi.org/10.1038/s41576-018-0004-3.

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31

Sharma-Oates, A., N. Rivera, N. Duggal, et al. "AB0091 INCREASED BIOLOGICAL AGE IN MALE PARTICIPANTS OF SWEDISH AND UK RHEUMATOID ARTHRITIS COHORTS IS NOT LINKED TO DISEASE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1177.1–1177. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4502.

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BackgroundImmunesenescence in the adaptive immune system, subsequent to thymic involution, results in compromised immunity and increased susceptibility to autoimmune disease and chronic inflammation. There are reports in the literature that immunesenescence, including thymic atrophy and telomere shortening, is accelerated in patients with rheumatoid arthritis (RA)1. What is unclear is whether RA includes accelerated biological ageing overall in addition to immune ageing which may help to explain the increased risk of age-related diseases in RA2. Recent studies have identified a set of DNA meth

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Dudek, Michal, Nan Yang, Jayalath PD Ruckshanthi, et al. "The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration." Annals of the Rheumatic Diseases 76, no. 3 (2016): 576–84. http://dx.doi.org/10.1136/annrheumdis-2016-209428.

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ObjectivesThe circadian clocks are internal timing mechanisms that drive ∼24-hour rhythms in a tissue-specific manner. Many aspects of the physiology of the intervertebral disc (IVD) show clear diurnal rhythms. However, it is unknown whether IVD tissue contains functional circadian clocks and if so, how their dysregulation is implicated in IVD degeneration.MethodsClock gene dynamics in ex vivo IVD explants (from PER2:: luciferase (LUC) reporter mice) and human disc cells (transduced with lentivirus containing Per2::luc reporters) were monitored in real time by bioluminescence photon counting a

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Wang, Yali, Dongjun Lv, Wenwen Liu, et al. "Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease." Oxidative Medicine and Cellular Longevity 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/4854732.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease and is known to involve circadian dysfunction and oxidative stress. Although antioxidative defense is regulated by the molecular circadian clock, few studies have examined their function in PD and their regulation by silent information regulator 1 (SIRT1). We hypothesize that reduced antioxidative activity in models of PD results from dysfunction of the molecular circadian clock via the SIRT1 pathway. We treated rats and SH-SY5Y cells with 6-hydroxydopamine (6-OHDA) and measured the expression of core circadian clock

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Chakarov, Stoyan, Rumena Petkova, George Ch Russev, and Nikolai Zhelev. "DNA damage and the circadian clock." BioDiscovery 13 (September 14, 2014): e8960. https://doi.org/10.7750/BioDiscovery.2014.13.1.

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The role of the circadian clock has already been demonstrated for virtually all physiological processes, but it was only recently shown that cells were more sensitive to DNA damage at specific times of the day; that the peak of synthesis of mRNA and proteins of genes coding for products involved directly or indirectly in DNA repair was differentially timed in different tissues; and that the growth of some types of cancer followed a circadian pattern. The paper reviews the specificities of the clockwork mechanism in living cells associated with repair of DNA damage with regards to its role in a

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35

Harley, Calvin B. "Telomere loss: mitotic clock or genetic time bomb?" Mutation Research/DNAging 256, no. 2-6 (1991): 271–82. http://dx.doi.org/10.1016/0921-8734(91)90018-7.

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36

Declerck, Ken, and Wim Vanden Berghe. "Back to the future: Epigenetic clock plasticity towards healthy aging." Mechanisms of Ageing and Development 174 (September 2018): 18–29. http://dx.doi.org/10.1016/j.mad.2018.01.002.

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37

Kippert, F. "An ultradian clock controls locomotor behaviour and cell division in isolated cells of Paramecium tetraurelia." Journal of Cell Science 109, no. 4 (1996): 867–73. http://dx.doi.org/10.1242/jcs.109.4.867.

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An ultradian clock operates in fast growing cells of the large ciliate, Paramecium tetraurelia. The period of around 70 minutes is well temperature-compensated over the temperature range tested, i.e. between 18 degrees C and 33 degrees C. The Q10 between 18 degrees C and 27 degrees C is 1.08; above 27 degrees C there is a slight overcompensation. The investigation of individual cells has revealed that two different cellular functions are under temporal control by this ultradian clock. First, locomotor behaviour, which is an alternation between a phase of fast swimming with only infrequent turn

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Pierpaoli, Walter. "The pineal gland: A circadian or seasonal aging clock?" Aging Clinical and Experimental Research 3, no. 2 (1991): 99–101. http://dx.doi.org/10.1007/bf03323985.

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Lujan, Celia, Eleanor Jane Tyler, Simone Ecker, et al. "An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo." Genome Medicine 16, no. 1 (2024). http://dx.doi.org/10.1186/s13073-024-01349-w.

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Abstract Background Restraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan and healthspan. Consequently, there is great interest in anti-ageing drug discovery. However, this currently requires laborious and lengthy longevity analysis. Here, we present a novel screening readout for the expedited discovery of compounds that restrain ageing of cell populations in vitro and enable extension of in vivo lifespan. Methods Using Illumina methylation arrays, we monitored DNA methylation changes accompanying long-term passaging of adu

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Green, Daniel C., Louise N. Reynard, James R. Henstock, et al. "MskAge—An Epigenetic Biomarker of Musculoskeletal Age Derived From a Genetic Algorithm Islands Model." Aging Cell, June 19, 2025. https://doi.org/10.1111/acel.70149.

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ABSTRACTAge is a significant risk factor for functional decline and disease of the musculoskeletal system, yet few biomarkers exist to facilitate ageing research in musculoskeletal tissues. Multivariate models based on DNA methylation, termed epigenetic clocks, have shown promise as markers of biological age. However, the accuracy of existing epigenetic clocks in musculoskeletal tissues are no more, and often less accurate than a randomly sampled baseline model. We developed a highly accurate epigenetic clock, MskAge, that is specific to tissues and cells of the musculoskeletal system. MskAge

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Xu, Kexin, Belinda Hernández, Thalida Em Arpawong, et al. "Assessing Metabolic Ageing via DNA Methylation Surrogate Markers: A Multicohort Study in Britain, Ireland and the USA." Aging Cell, January 20, 2025. https://doi.org/10.1111/acel.14484.

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ABSTRACTMetabolomics and epigenomics have been used to develop ‘ageing clocks’ that assess biological age and identify ‘accelerated ageing’. While metabolites are subject to short‐term variation, DNA methylation (DNAm) may capture longer‐term metabolic changes. We aimed to develop a hybrid DNAm‐metabolic clock using DNAm as metabolite surrogates (‘DNAm‐metabolites’) for age prediction. Within the UK Airwave cohort (n = 820), we developed DNAm metabolites by regressing 594 metabolites on DNAm and selected 177 DNAm metabolites and 193 metabolites to construct ‘DNAm‐metabolic’ and ‘metabolic’ clo

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Dudek, Michal, Joe Swift, and Qing-Jun Meng. "The circadian clock and extracellular matrix homeostasis in ageing and age-related diseases." American Journal of Physiology-Cell Physiology, May 29, 2023. http://dx.doi.org/10.1152/ajpcell.00122.2023.

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The extracellular matrix (ECM) is the non-cellular scaffolding component present within all tissues and organs. It provides crucial biochemical and biomechanical cues to instruct cellular behaviour and has been shown to be under circadian clock regulation, a highly conserved cell-intrinsic time keeping mechanism that has evolved with the 24-hour rhythmic environment. Ageing is a major risk factor for many diseases, including cancer, fibrosis and neurodegenerative disorders. Both ageing and our modern 24/7 society disrupt circadian rhythms, which could contribute to altered ECM homeostasis. Und

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Poulsen, Raewyn C., James I. Hearn, and Nicola Dalbeth. "The circadian clock: a central mediator of cartilage maintenance and osteoarthritis development?" Rheumatology, February 25, 2021. http://dx.doi.org/10.1093/rheumatology/keab197.

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Abstract The circadian clock is a specialized cell signalling pathway present in all cells. Loss of clock function leads to tissue degeneration and premature ageing in animal models demonstrating the fundamental importance of clocks for cell, tissue and organism health. There is now considerable evidence that the chondrocyte circadian clock is altered in OA. The purpose of this review is to summarize current knowledge regarding the nature of the change in the chondrocyte clock in OA and the implications of this change for disease development. Expression of the core clock component, BMAL1, has

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Neytchev, Ognian, Anna Witasp, Louise Nordfors, et al. "FC 123RENAL TRANSPLANTATION MITIGATES INCREASED BIOLOGICAL (EPIGENETIC) AGE IN CHRONIC KIDNEY DISEASE." Nephrology Dialysis Transplantation 36, Supplement_1 (2021). http://dx.doi.org/10.1093/ndt/gfab147.002.

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Abstract Background and Aims Chronic kidney disease (CKD) shares important features of a dysregulated ageing process with other common “burden of lifestyle” diseases, which aggregates into the diseasome of ageing. Typically, this is hallmarked by an acceleration of epigenetic (DNA methylation-based) clocks. It remains to be determined if current therapeutic interventions, such as renal transplantation or dialysis, can slow this clock, and thus the rate of biological ageing, in CKD. We therefore assessed the rate of biological ageing in CKD patients and whether these therapies impact on it, by

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Haller, Ayke, Judith Risse, Bernice Sepers, and Kees van Oers. "Independent Avian Epigenetic Clocks for Ageing and Development." Molecular Ecology Resources, June 3, 2025. https://doi.org/10.1111/1755-0998.14128.

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ABSTRACTInformation on individual age is a fundamental aspect in many ecological and evolutionary studies. However, accurate and non‐lethal methods that can be applied to estimate the age of wild animals are often absent. Furthermore, since the process of ageing is accompanied by a physical decline and the deterioration of biological functions, the biological age often deviates from the chronological age. Epigenetic marks are widely suggested to be associated with this age‐related physical decline, and especially changes in DNA methylation are suggested to be reliable age‐predictive biomarkers

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Wang, Yucheng, Olivia A. Grant, Xiaojun Zhai, Klaus D. Mcdonald-Maier, and Leonardo C. Schalkwyk. "Insights into ageing rates comparison across tissues from recalibrating cerebellum DNA methylation clock." GeroScience, August 19, 2023. http://dx.doi.org/10.1007/s11357-023-00871-w.

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AbstractDNA methylation (DNAm)-based age clocks have been studied extensively as a biomarker of human ageing and a risk factor for age-related diseases. Despite different tissues having vastly different rates of proliferation, it is still largely unknown whether they age at different rates. It was previously reported that the cerebellum ages slowly; however, this claim was drawn from a single clock using a relatively small sample size and so warrants further investigation. We collected the largest cerebellum DNAm dataset (N = 752) to date. We found the respective epigenetic ages are all severe

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Koreki, Akihiro, Keisuke Kusudo, Hisaomi Suzuki, et al. "Are Analogue or Digital Clocks Friendlier for People Living with Dementia?" Dementia and Geriatric Cognitive Disorders Extra, September 13, 2021, 207–12. http://dx.doi.org/10.1159/000518350.

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<b><i>Background:</i></b> In ageing population, it is desirable to reduce the impact of cognitive decline on daily life. While various types of dementia-friendly environments have been proposed, the question still remains regarding whether analogue or digital clocks are friendlier for people with dementia. <b><i>Methods:</i></b> In clinical practice, we normally use our original clock reading test (10 analogue and 10 digital clocks) to assess patients’ ability to read a clock. In the present study, a retrospective medical record survey was conduc

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Kawakami, Satoshi, Hikari Yoshitane, Taiki Morimura, Wataru Kimura, and Yoshitaka Fukada. "Diurnal shift of mouse activity by the deficiency of an ageing-related gene Lmna." Journal of Biochemistry, February 8, 2022. http://dx.doi.org/10.1093/jb/mvac015.

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Abstract Nuclear lamina is a fundamental structure of the cell nucleus and regulates a wide range of molecular pathways. Defects of components of the nuclear lamina cause ageing-like physiological disorders, called laminopathy. Generally, ageing and diseases are often associated with perturbation of various time-of-day–dependent regulations, but it remains elusive whether laminopathy induces any changes of the circadian clock and physiological rhythms. Here, we demonstrated that deficiency of Lmna gene in mice caused an obvious shift of locomotor activities to the daytime. The abnormal activit

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Shireby, Gemma L., Jonathan P. Davies, Paul T. Francis, et al. "Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex." Brain, October 29, 2020. http://dx.doi.org/10.1093/brain/awaa334.

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Abstract Human DNA methylation data have been used to develop biomarkers of ageing, referred to as ‘epigenetic clocks’, which have been widely used to identify differences between chronological age and biological age in health and disease including neurodegeneration, dementia and other brain phenotypes. Existing DNA methylation clocks have been shown to be highly accurate in blood but are less precise when used in older samples or in tissue types not included in training the model, including brain. We aimed to develop a novel epigenetic clock that performs optimally in human cortex tissue and

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Morena da Silva, Francielly, Karyn A. Esser, Kevin A. Murach, and Nicholas P. Greene. "Inflammation o'clock: interactions of circadian rhythms with inflammation‐induced skeletal muscle atrophy." Journal of Physiology, August 10, 2023. http://dx.doi.org/10.1113/jp284808.

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AbstractCircadian rhythms are ∼24 h cycles evident in behaviour, physiology and metabolism. The molecular mechanism directing circadian rhythms is the circadian clock, which is composed of an interactive network of transcription–translation feedback loops. The core clock genes include Bmal1, Clock, Rev‐erbα/β, Per and Cry. In addition to keeping time, the core clock regulates a daily programme of gene expression that is important for overall cell homeostasis. The circadian clock mechanism is present in all cells, including skeletal muscle fibres, and disruption of the muscle clock is associate

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