Academic literature on the topic 'Agent lysosomotrope'

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Journal articles on the topic "Agent lysosomotrope"

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Firestone, Raymond A., Judith M. Pisano, George M. Garrity, Robert A. Fromtling, and Sheldon B. Zimmerman. "Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents." Journal of Medicinal Chemistry 30, no. 8 (1987): 1519–21. http://dx.doi.org/10.1021/jm00391a043.

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MIR, MUDASIR. "LYSOSOMOTROPIC PROPERTIES OF SODIUM BICARBONATE AND COVID-19." FARMACIA 68, no. 5 (2020): 771–78. http://dx.doi.org/10.31925/farmacia.2020.5.1.

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SARS-CoV-2 causing COVID-19 has appeared as an ongoing global public crisis, growing with geometric progression and has caused huge devastation till date majorly because of lack of targeted therapeutic agents like vaccines. SARS-Cov-2 entrance into the host cells is reliant on acidic pH. Thus, in the current clinical emergency there is a pressing need to look forward for adjunct therapies which could counter the acidic pH, so as to restrain the viral entry and its subsequent reproduction in the host cells. Therefore, the current review attempted to explore the possibility to use sodium bicarbo
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Kalina, M., and R. Socher. "Endocytosis in cultured rat alveolar type II cells: effect of lysosomotropic weak bases on the processes." Journal of Histochemistry & Cytochemistry 39, no. 10 (1991): 1337–48. http://dx.doi.org/10.1177/39.10.1658127.

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We investigated the uptake of Lucifer yellow and surfactant complexed with gold (S-G) by isolated alveolar Type II cells. The fluid phase marker Lucifer yellow did not reach lamellar bodies (LB) even after prolonged incubation time, whereas S-G was internalized and found in LB. Treatment of Type II cells with lysosomotropic weak bases (NH4Cl and chloroquine) resulted in dilation of endosomes, lysosomes, and LB. The effect of these agents on LB resulted in disappearance of their lamellar organization, as detected by polarized light and electron microscopy. After incubation in lysosomotropic age
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Villamil Giraldo, Ana M., Hanna Appelqvist, Thomas Ederth, and Karin Öllinger. "Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death." Biochemical Society Transactions 42, no. 5 (2014): 1460–64. http://dx.doi.org/10.1042/bst20140145.

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Lysosomes are acidic organelles essential for degradation, signalling and cell homoeostasis. In addition, they play a key role in cell death. Permeabilization of the lysosomal membrane and release of hydrolytic enzymes to the cytosol accompanies apoptosis signalling in several systems. The regulatory mechanism of lysosomal stability is, however, poorly understood. Lipophilic or amphiphilic compounds with a basic moiety will become protonated and trapped within lysosomes, and such lysosomotropic behaviour is also found in many pharmacological drugs. The natural sphingolipid sphingosine exhibits
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Chen, Grace L., Sarah L. Sutrina, Karen L. Frayer, and Winston W. Chen. "Effects of lysosomotropic agents on lipogenesis." Archives of Biochemistry and Biophysics 245, no. 1 (1986): 66–75. http://dx.doi.org/10.1016/0003-9861(86)90190-6.

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Xiong, Subin, Hong Li, Bo Yu, Jun Wu, and Robert J. Lee. "Triggering Liposomal Drug Release With a Lysosomotropic Agent." Journal of Pharmaceutical Sciences 99, no. 12 (2010): 5011–18. http://dx.doi.org/10.1002/jps.22210.

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Doi, Syuichi, Kazuyuku Tanabe, Masayasu Watanabe, and Masao Yoshimura. "Chloroquine, a lysosomotropic agent, inhibits zygote formation in yeast." Archives of Microbiology 151, no. 1 (1988): 20–25. http://dx.doi.org/10.1007/bf00444663.

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Liu, Zhenxing, Shuan Zhao, Shuaishuai Wu, Jingyou Zhang, Zunyang Nie, and Shenming Zeng. "A novel role of transient receptor potential mucolipin1 (TRPML1) in protecting against imidazole-induced cytotoxicity." Biochemistry and Cell Biology 92, no. 4 (2014): 279–86. http://dx.doi.org/10.1139/bcb-2014-0044.

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Lysosomotropic amines cause serious side effects such as cytoplasmic vacuolation and cell death. TRPML1 (also known as mucolipin1), a member of the transient receptor potential (TRP) protein family, may regulate fusion/fission of vesicles along the endocytic pathway and some aspects of lysosomal ion homeostasis. Nevertheless, it is still unknown whether TRPML1 is involved in death of mammalian cells induced by lysosomotropic agents. In this study, imidazole was used as a model to investigate the role of TRPML1 in the cytotoxicity of lysosomotropic agents. Overexpression of wild-type TRPML1 inh
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SHAMSADEEN, NASRIN, and C. J. DUNCAN. "Action of lysosomotropic agents on mammalian skeletal muscle." Biochemical Society Transactions 16, no. 5 (1988): 786. http://dx.doi.org/10.1042/bst0160786.

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Duncan, R. "Designing polymer conjugates as lysosomotropic nanomedicines." Biochemical Society Transactions 35, no. 1 (2007): 56–60. http://dx.doi.org/10.1042/bst0350056.

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Marriage of cell biology (the concept of ‘lysosomotropic drug delivery’) and the realization that water-soluble synthetic polymers might provide an ideal platform for targeted drug delivery led to the first synthetic polymer–drug conjugates that entered clinical trials as anticancer agents. Conceptually, polymer conjugates share many features with other macromolecular drugs, but they have the added advantage of the versatility of synthetic chemistry that allows tailoring of molecular mass and addition of biomimetic features. Conjugate characteristics must be optimized carefully to ensure that
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Dissertations / Theses on the topic "Agent lysosomotrope"

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Maurin, Max. "Rôle du pH phagolysosomial dans l'action des antibiotiques sur les bactéries intracellulaires." Paris 7, 1994. http://www.theses.fr/1994PA077067.

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L'absence d'activité d'un antibiotique sur un microorganisme à vie intracellulaire peut correspondre à son incapacité à pénétrer dans la cellule eucaryote, a une localisation subcellulaire différente de celle du microorganisme considéré, ou à une inactivation intracellulaire de l'antibiotique. Nous avons testé l'hypothèse d'une inactivation des antibiotiques dans le milieu phagolysosomial acide, à travers deux modèles de bactéries vivant dans ce compartiment cellulaire ; staphylococcus aureus et coxiella burnetii. Nous avons vérifié dans un premier temps la possibilité d'alcaliniser le ph phag
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Book chapters on the topic "Agent lysosomotrope"

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Orsi, E. V., S. Joshi, M. Bavlsik, M. Petersheim, and Y. Peng. "Effects of Benzene and Other Lysosomotropic Agents on Ultraviolet Light Induced Photolysis of Lysosomes in Herpesvirus Infected Cells." In Environmental Hygiene. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73766-4_10.

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