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Journal articles on the topic 'Agenți anticancer'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Ana, LEORDA, and TOLSTENCO Dorina. "ROLUL PLANTELOR MEDICINALE ONCOPROTECTOARE ȘI AL REMEDIILOR PE BAZA LOR ÎN TERAPII ANTICANCER." STUDIA UNIVERSITATIS MOLDAVIAE Științe Reale și ale Naturii, no. 6(156) (2022): 53–59. https://doi.org/10.5281/zenodo.7442397.

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În articol au fost elucidate unele mecanisme de acțiune relevante ale plantelor medicinale oncoprotectoare și ale<strong> remediilor pe baza lor</strong> în terapii complementare anticancer. Având în vedere efectele secundare, toxicitatea și costurile mari, inerente terapiilor anticancer tradiționale, rămâne a fi actuală identificarea de noi compuși din surse naturale, inclusiv plante medicinale sigure și eficiente împotriva chimiorezistenței și împotriva cancerului, ceea ce oferă perspective promițătoare în tratarea acestei m

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K., Gandhi Mansi, and Dr Shashi V. Ranga. "Insights into Quinoline Schiff Bases as Anticancer Agents." International Journal of Research Publication and Reviews 5, no. 11 (2024): 526–38. http://dx.doi.org/10.55248/gengpi.5.1124.3116.

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3

Dikusar, E. A. "Quantum chemical designing of cholesterol containing radionuclide anticancer agents." Functional materials 23, no. 2 (2016): 274–78. http://dx.doi.org/10.15407/fm23.02.274.

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El-Sayed, Ashraf S. A., Manal T. El Sayed, Hend S. Nada, Abdallah E. Hassan, and Eman K. Yousef. "Production and Characterization of Taxol as Anticancer Agent from Aspergillus terreus." Journal of Pure and Applied Microbiology 13, no. 4 (2019): 2055–63. http://dx.doi.org/10.22207/jpam.13.4.17.

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Kundu, Nilesh. "Copper Nanoparticles as Emerging Anticancer Agents: Mechanistic Insights, Therapeutic Potential, and Future Perspectives." International Journal of Research Publication and Reviews 6, no. 5 (2025): 7912–20. https://doi.org/10.55248/gengpi.6.0525.1807.

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Mankhi, Rusul Naeim, and Nabeel A. Abdul-Rida. "NEW FENOFIBRATE DERIVATIVES AS ANTICANCER AND ANTIOXIDANT AGENTS: SYNTHESIS, IN SILICO STUDY AND BIOLOGICAL EVALUATION." Chemical Problems 23, no. 2 (2025): 286–93. https://doi.org/10.32737/2221-8688-2025-2-286-293.

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Fenofibrate is a medication derived from fibric acid that is used to treat severe cases of high triglyceride levels and a combination of abnormal lipid levels in individuals who have not shown improvement with nonpharmacological treatments. As part of this research, novel classes of Fenofibrate derivatives were synthesized and evaluated in vitro as anticancer and antioxidant agents. Spectroscopic techniques, including infrared, NMR and elemental analysis, were used to validate their structures conclusively. all products were screened in vitro against cell lines MDA-MB-231. The cytotoxicity ass

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Abdul-Rida, Nabeel A., and Kawther M. Talib. "NEW CHALCONE DERIVATIVES AS ANTICANCER AND ANTIOXIDANT AGENTS: SYNTHESIS, MOLECULAR DOCKING STUDY AND BIOLOGICAL EVALUATION." Chemical Problems 22, no. 2 (2024): 177–86. http://dx.doi.org/10.32737/2221-8688-2024-2-177-186.

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In this approach, a series of new chalcone derivatives bearing baclofen drug were synthesized via Claisen-Schmidt condensation and evaluated in vitro as anticancer and antioxidant agents. The newly synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR spectra, and elemental analysis. All products were screened in vitro against both cell lines HdFn and MCF-7. The cytotoxicity assay results revealed that derivatives 5a and 5d exhibited good inhibition for cell lines MCF-7 with IC50 values 32.5 and 37.6 µM, respectively while 5a and 5c exhibited acceptable inhibition for HdFn with IC

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C.A, Mbah, Okonkwo S.C, Nwaume E.J, Olawoore F.R, and Abah E.I. "Traditional African Medicinal Plants as Potential Sources of Anticancer Agents: Bioactive Compounds, Mechanisms, and Future Directions." International Journal of Research Publication and Reviews 6, no. 5 (2025): 11679–91. https://doi.org/10.55248/gengpi.6.0525.18121.

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Yashwant, B.Srivastava, K. Sharma Brij, and Gaur Kalpesh. "A Probable Target for Novel Anticancer Agents: Cdc25 Phosphatases as Cyclin-Dependent Kinase Inhibitors." International Journal of Current Pharmaceutical Review and Research 1, no. 1 (2010): 76–82. https://doi.org/10.5281/zenodo.12699668.

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There are many different types of cancer, but all share a common feature – rapid anduncontrolled cell proliferation. Emergence of new tumors is associated with mutations orabnormalities in expression of various cell cycle regulators like cyclins and cyclindependent kinases (Cdk). Cell Division Cycle 25 (Cdc25) Phosphatases are DualSpecificity Phosphatases (DSP) that dephosphorylate and activate the Cdk/cyclincomplexes, thereby playing a fundamental role in transitions between cell cycle phases. 

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Ali, M. M., M. M. Ramadan, K. Z. Ghanem, and A. H. El-Ghorabe. "Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines." Grasas y Aceites 66, no. 2 (2015): e080. http://dx.doi.org/10.3989/gya.0955142.

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Biswanath, Das, N. S. Srinivas K.V., Ravindranath N., Ramesh C., Venkataiah B., and Das Ratna. "Acid catalyzed conversions of taxoids." Journal of Indian Chemical Society Vol. 78, Oct-Dec 2001 (2001): 667–70. https://doi.org/10.5281/zenodo.5912451.

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Organic Chemistry Division-!, Indian Institute of Chemical Technology, Hyderabad-500 007, India <em>E-mail</em> : biswanathdas@yahoo.com Department of Chemistry, Gurudas College, Narkeldanga Main Road, Kolkata-700 054, India <em>Manuscript received 11 May 2001</em> Treatment of 10-deacetylbaccatin-III and baccatin-III with dilute HCI affords 10deacetylbaccatin-V and baccatin-V, respectively. 10-Deacetylbaccatin-V is also obtained when 10-deacetylbaccatin-III is treated with ZnCI<sub>2</sub> or ZnBr<sub>2</sub> in MeOH. These two Lewis acids convert baccatin-III to 10-deacetylbaccatin-III as we

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Pavan, Sable* Mangesh Randive Amol Shirode. "Medicinal Chemistry of Anticancer Drugs." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 171–1720. https://doi.org/10.5281/zenodo.15209176.

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In recent decades, combating cancer and preventing its onset have become major priorities for healthcare systems worldwide. Significant progress has been made in both treating various types of cancer and improving survival rates, thanks to advancements in therapeutic methods and the development of effective antitumor drugs. Today, the discovery and creation of anticancer medications are key areas of focus for pharmaceutical companies, research institutions, and both government and non-government organizations globally. Remarkable strides have been made in identifying and developing drugs that

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SUDIN, BBHATTA CHARYA, DUTTA SUSANTA, and SANYAL UTPAL. "Synthesis and Evaluation of Sulphonylhydrazones of Phthalimido Acetaldehyde as Anticancer Agents." Journal of Indian Chemical Society Vol. 75, Jan 1998 (1998): 46–48. https://doi.org/10.5281/zenodo.5913177.

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Department of Anticancer Drug Development & Chemotherapy, Chittaranjan National Cancer Institute, Calcutta-700 026 <em>Manuscript received 15 January 1996, revised 25 September 1996, accepted 6 March 1997</em> Synthesis and Evaluation of Sulphonylhydrazones of Phthalimido Acetaldehyde as Anticancer Agents.

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Albatsh, Musa. "Investigation of the promising repurposed, computational, and anticancer candidates to co-deliver with cabazitaxel for hormonal-resistance prostate cancer." Pharmacia 72 (April 7, 2025): 1–10. https://doi.org/10.3897/pharmacia.72.e143676.

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The novel antimicrotubular taxane called cabazitaxel was developed to avoid the primary mechanism of resistance for docetaxel, the first-line treatment for patients with hormone-resistant prostate cancer (HRPC). However, its ability to increase the survival rate for HRPC is limited to a few months, and cabazitaxel-resistant prostate cancer was also developed. Consequently, this review aims to assess the repurposing, computational, and anticancer candidates that may be used in conjunction with cabazitaxel to improve its antiproliferative efficacy against prostate cancer. This work reveals that

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Vivek, Parashar, and Nayak Amit. "Nephrotoxic Effects of Carboplatin, A New Potential Anticancer Agent, in Mice: A Teratological Study." International Journal of Pharmaceutical and Clinical Research 16, no. 4 (2024): 414–17. https://doi.org/10.5281/zenodo.11176760.

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Cisplatin [cis-dichlorodiammineplatinum (II)], the first generation anticancer platinum complex, is one of the most effective anticancer agents currently available for the treatment of testicular, ovarian, and bladder carcinomas. But its clinical usefulness has frequently been limited by undesirable side effects such as nephrotoxicity, gastrointestinal toxicity, ototoxicity, and neurotoxicity. The present study was conducted in collaboration with Department of anatomy, Institute of medical sciences, Banaras Hindu University, Varanasi. Animals – Fourty female albino mice of an average wei

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Soheila, Azim Patrawala*1 Dr. Bhavini Gharia1 Amankumar Vaghasiya2. "Insilico Studies and Synthesis of New 2-Cycloproply Quinazoline Derivatives as Potential Anticancer Agents." International Journal of Scientific Research and Technology 2, no. 4 (2025): 306–20. https://doi.org/10.5281/zenodo.15212322.

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The quinazoline scaffold is of significant importance in medicinal chemistry due to the diverse pharmacological activities of its derivatives, particularly their prominent role in cancer chemotherapy. In our continuous pursuit of novel anticancer pharmacophores, we aimed to synthesize a series of substituted quinazolines fused with substituted benzothiazoles and assess their in vitro anticancer potential. We commenced this endeavor by reacting anthranilic acid with cyclopropyl carbonyl chloride in the presence of 2,6-lutidine to yield an oxazine intermediate, which was subsequently converted i

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Savage, P., C. Holloway, G. Lindsay, et al. "Cancer referral and treatment activity 2010–2015: a population-based study from Vancouver Island." Current Oncology 23, no. 6 (2016): 626. http://dx.doi.org/10.3747/co.23.3306.

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Introduction The years since 2005 have seen major changes in cancer treatment and significant increases in the number of anticancer drugs available. However, there are relatively few published data to reflect how those changes are affecting the activity and workload of oncology services. To explore the effects of those changes, we reviewed the population-based cancer treatment activity on Vancouver Island for the period 2010–2015.Methods Information about new patient referrals, radiation courses, new chemotherapy cycles commenced, total intravenous (IV) chemotherapy treatment visits, and pharm

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Trotta, Francesco, Hubert G. M. Leufkens, Jan H. M. Schellens, Richard Laing, and Giovanni Tafuri. "Evaluation of Oncology Drugs at the European Medicines Agency and US Food and Drug Administration: When Differences Have an Impact on Clinical Practice." Journal of Clinical Oncology 29, no. 16 (2011): 2266–72. http://dx.doi.org/10.1200/jco.2010.34.1248.

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Purpose The aims of this study were to compare the approaches of the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) in the evaluation and approval of new anticancer indications and to identify possible clinical implications associated with these differences. Methods Information on the European Union therapeutic indications for the cohort of anticancer drugs was extracted from the European Public Assessment Reports and from the FDA review reports. Results Overall, 42 anticancer drugs were approved by EMA between 1995 and 2008, corresponding to a total of 100 indic

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Patil, Sunita* Kalal Laxmi. "Anticancer Potential of Plant and Natural Product." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1477–85. https://doi.org/10.5281/zenodo.15034793.

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One of the main causes of death is cancer, and its incidence is steadily rising throughout the world. Numerous illnesses, including cancer, have been treated with traditional medicine, its active compounds, and certain natural products. There are a number of medications on the market to treat different kinds of cancer, but none of them have been proven to be completely safe and effective. The toxicity of the current medications is the main issue with cancer chemotherapy. Nonetheless, plants and medicines derived from them have shown promise in the management and treatment of cancer. There are

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Mohd, Ateek* Shahnawaz Ahmad. "Recent Advancements in Naphthofuran Derivatives as Anti-Cancer Agents." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 1254–62. https://doi.org/10.5281/zenodo.15609629.

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Cancer remains a leading cause of mortality worldwide, underscoring the urgent need for novel and effective therapeutic strategies. Naphthofurans, a class of heterocyclic compounds possessing a fused furan and naphthalene ring system, have emerged as promising candidates for anticancer drug development due to their diverse biological activities and structural versatility. This review provides an overview of recent advancements in the design, synthesis, and evaluation of naphthofuran derivatives as anticancer agents. We will examine the various mechanisms of action targeted by these compounds,

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Kоbylinska, L., D. Khylyuk, I. Subtelna, M. Kitsera, and R. Lesyk. "In silico identification and biochemical validation of plausible molecular targets of 4-thiazolidinone derivative Les-3833 as a potential anticancer agent." Ukrainian Biochemical Journal 93, no. 2 (2021): 7–22. http://dx.doi.org/10.15407/ubj93.02.007.

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Vishesh, Verma, Sharma Shivam, Gaur Kritika, and Kumar Nitin. "Role of vinca alkaloids and their derivatives in cancer therapy." World Journal of Advanced Research and Reviews 16, no. 3 (2022): 794–800. https://doi.org/10.5281/zenodo.7903763.

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Vinca alkaloids and its derivatives like Vincristine, Vinblastine etc. isolated from <em>Catharanthus roseus</em> plants are widely used in the treatment of various types of cancers. Mode of action of Vinca alkaloids (vinblastine, vincristine, vinorelbine) is microtubule-stabilizing agents (MTAs) i.e., arrest the cell cycle via disrupting microtubule dynamics. Vincristine major side effect is neurotoxicity. Hoverer, Vincristine induce neuropathy in mice or rat, used as animal model to study effect of drugs or plants by various authors also reported in review literature. Vinca alkaloi

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Tarun, Jha, Samanta Soma, Kumar Halder Amit, et al. "Synthesis, biological evaluation, and enzyme assay of some 5-N-substituted-2-N- (arylsulphonyl)-L(+)glutamines as potential anticancer agents." Journal of Indian Chemical Society Vol. 97, Aug 2020 (2020): 1259–64. https://doi.org/10.5281/zenodo.5656673.

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Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, India Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Jadavpur, Kolkata-700 032, India <em>E-mail</em>: tjupharm@yahoo.com <em>Manuscript received online 03 July 2020, accepted 30 July 2020</em> Thirty 5-N-substituted-2-N-(arylsulphonyl)-L(+)glutamines were synthesized and evaluated biologically for their anticancer activities. The best active compound of this series showed 92.92% inhibition of tumor weight against Ehrl

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Tsuji, Akihito. "New concept infusion pump with an anticancer drug exposure prevention function." Journal of Clinical Oncology 41, no. 16_suppl (2023): e18722-e18722. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e18722.

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e18722 Background: In recent years, cancer chemotherapy has taken measures to prevent exposure to anticancer drugs. Major exposure prevention measures include the use of safety cabinets and closed dispensing devices during preparation, closed infusion sets, and patient education to avoid exposure to the surrounding environment, such as through defecation. On the other hand, the closed circuit needs to be opened after the continuous infusion pumping of anticancer drugs, and the risk of exposure to anticancer drugs during this process remains an issue. In response to this issue, we aimed to deve

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Ali-Kakeshpour, Ashraf-Moradi, and Farzaneh-Moradi. "Green synthesis of potent anticancer and antibacterial xanthene and chromene derivatives using agar as a catalyst: Molecular docking and in silico ADMET insights." World Journal of Biology Pharmacy and Health Sciences 18, no. 3 (2024): 135–65. https://doi.org/10.5281/zenodo.13766584.

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This study presents an innovative green synthesis method for xanthene, benzoxanthene, and chromene derivatives using agar as a natural catalyst. Our method achieves high yields (up to 95%) with short reaction times (less than 1 hour) under environmentally friendly conditions and simple work-up procedures. The docking analysis conducted provides insights into the complex binding energies, molecular interactions, and hydrogen bond energies and distances. Molecular docking studies reveal strong chemical interactions with human serum albumin (HSA) and DNA gyrase, suggesting strong anticancer and a

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Shanthi, N. 1. *. Murugesan S. 1. Janetta Nithia S. 2. and Kotteswari M. 1. "IN VITRO ANTICANCER ACTIVITY OF METHANOL EXTRACTS OF AVICENNIA MARINA (FORSSK) VIREH AGAINST HT-29 COLON CANCER CELL LINE." Journal of Pharma Research 8, no. 6 (2019): 420–23. https://doi.org/10.5281/zenodo.3265336.

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<strong><em>ABSTRACT</em></strong> <strong><em>I</em></strong><em>n the present study the crude methanol extracts of Avicennia marina were prepared by using soxhlet apparatus and to investigate the efficacy of the extract against HT-29 cell line. The anticancer activity of A. marina leaf extract on proliferation of HT-29 cancer cell line was determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) microculture tetrazolium viability assay. The colon cancer cell was exposed to different concentration 7.8, 15.6, 31.2, 62.5, 125, 250, 500 and 1000 μg/ml. About 50% rise

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Arvind, Umarkar, Rathi Radhika, Parhad Pravin, Mapari Mangesh, and Shah Sapan. "Isatin as a Novel Anticancer Agent: Mechanisms and Potential in Breast Cancer Treatment." Journal of Research and Reviews in Yoga & Ayurvedic Sciences 2, no. 2 (2025): 1–12. https://doi.org/10.5281/zenodo.15423991.

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<em>Isatin (1H-indole-2,3-dione) is a naturally occurring molecule having </em>a range of<em> </em><em>pharmacological alterations, especially anti-cancer effects. Recent research has emphasized its potential as an anti-breast cancer drug, owing </em><em>to</em> <em>ability to decrease tumor cell growth, induce apoptosis, and modify critical signaling pathways involved in cancer progression. Isatin works through a range of processes, including angiogenesis inhibition, metastasis suppression, and cell cycle control. Furthermore, its capacity to interact with biological pathways such as the PI3K

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Hsu, Ya-Fen, Fan-Lu Kung, Tzu-En Huang, et al. "Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma Cells." Molecules 28, no. 5 (2023): 2358. http://dx.doi.org/10.3390/molecules28052358.

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Hepatocellular carcinoma is the third most common cause of cancer-related death according to the International Agency for Research on Cancer. Dihydroartemisinin (DHA), an antimalarial drug, has been reported to exhibit anticancer activity but with a short half-life. We synthesized a series of bile acid–dihydroartemisinin hybrids to improve its stability and anticancer activity and demonstrated that an ursodeoxycholic–DHA (UDC-DHA) hybrid was 10-fold more potent than DHA against HepG2 hepatocellular carcinoma cells. The objectives of this study were to evaluate the anticancer activity and inves

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Attarde, S. S., and S. V. Pandit. "Scorpion Venom as Therapeutic Agent - Current Perspective." International Journal of Current Pharmaceutical Review and Research 7, no. 2 (2016): 59–72. https://doi.org/10.5281/zenodo.12681160.

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Scorpions and their venoms have been employed in medication since thousands of years in Asia. The scorpion venom isan extremely advanced mixture of salts, nucleotides, biogenic amines, enzymes, mucoproteins, peptides and proteins (e.g.Neurotoxins). Scorpion venoms contain peptides that block or modify ion-channel function and present some doableapplications to regulate cell excitability. Specific literature regarding the results of scorpion venom elements on T-celldifferentiation, autoimmunity as well as on cardiac, haematological, neoplastic and infectious diseases has been revised inthis art

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Mason, Anne, Michael Drummond, Scott Ramsey, Jonathan Campbell, and Dennis Raisch. "Comparison of Anticancer Drug Coverage Decisions in the United States and United Kingdom: Does the Evidence Support the Rhetoric?" Journal of Clinical Oncology 28, no. 20 (2010): 3234–38. http://dx.doi.org/10.1200/jco.2009.26.2758.

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Purpose In contrast to the United States, several European countries have health technology assessment programs for drugs, many of which assess cost effectiveness. Coverage decisions that consider cost effectiveness may lead to restrictions in access. Methods For a purposive sample of five decision-making bodies, we analyzed US and United Kingdom coverage decisions on all anticancer drugs approved by the US Food and Drug Administration (FDA) from 2004 to 2008. Data sources for the timing and outcome of licensing and coverage decisions included published and unpublished documentation, Web sites

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Saadh, Mohamed. "Anticancer and antiproliferative activity of ruthenium complex (II) bearing 3,3'-dicarboxy-2,2'-bipyridine ligand." Pharmacia 70, no. (3) (2023): 803–7. https://doi.org/10.3897/pharmacia.70.e111508.

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Even though significant progress has been made in cancer treatment, there is always room for improvement. The experimental drug Ruthenium Complex II shows promise as a cancer treatment. In this article, the dichloro-3,3'-dicarboxy-2,2'-bipyridyl bis(dimethylsulphoxide)ruthenium(II) [RuCl<sub>2</sub>(3,3'-dcbpy)(DMSO)<sub>2</sub>], have been synthesized, characterized, and studied for its anticancer activity against MDA-MB-231 and MRC-5 cell lines, as well as its mechanisms of action and selectivity. According to research, [RuCl<sub>2</sub> (3,3'-dcbpy)(DMSO)<sub>2</sub>], is highly cytotoxic t

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Jung, Jae Ho, Dae Jung Kim, Kangho Suh, et al. "International Price Comparisons of Anticancer Drugs: A Scheme for Improving Patient Accessibility." International Journal of Environmental Research and Public Health 18, no. 2 (2021): 670. http://dx.doi.org/10.3390/ijerph18020670.

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Background: The demand for implementing a new listing scheme to expedite patient access to novel oncology drugs has increased in South Korea. This study was conducted to compare the prices of anticancer drugs between eight countries and to explore the feasibility of a ‘pre-listing and post-evaluation’ scheme to expedite patient access to oncology drugs. Methods: This study included 34 anticancer drugs, which were reimbursed between 1 January 2007 and 31 December 2017. The unit price and sales volume of the study drugs were collected from eight countries and IQVIA data, respectively. The prices

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Jiménez-González, Víctor, Tomasz Kowalczyk, Janusz Piekarski, Janusz Szemraj, Patricia Rijo, and Przemysław Sitarek. "Nature’s Green Potential: Anticancer Properties of Plants of the Euphorbiaceae Family." Cancers 16, no. 1 (2023): 114. http://dx.doi.org/10.3390/cancers16010114.

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The number of cancer cases will reach 24 million in 2040, according to the International Agency for Research on Cancer. Current treatments for cancer are not effective and selective for most patients; for this reason, new anticancer drugs need to be developed and researched enough. There are potentially useful drugs for cancer isolated from plants that are being used in the clinic. Available information about phytochemistry, traditional uses, in vitro and in vivo experiments with plants, and pure compounds isolated from the Euphorbiaceae family indicates that this family of plants has the pote

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Trotta, Francesco, Flavia Mayer, Francesco Barone-Adesi, et al. "Anticancer drug prices and clinical outcomes: a cross-sectional study in Italy." BMJ Open 9, no. 12 (2019): e033728. http://dx.doi.org/10.1136/bmjopen-2019-033728.

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ObjectiveTo investigate whether the prices of new anticancer drugs correlated with their relative benefit despite negotiation.DesignRetrospective cross-sectional study correlating new anticancer drugs prices with clinical outcomes.SettingWe did a retrospective cross-sectional study including all new anticancer drugs approved by the European Medicines Agency (EMA) (2010–2016) and reimbursed in Italy.Main outcome(s) and measure(s)Information on clinical outcomes—in terms of median overall survival (OS), median progression-free survival (PFS) and objective response rate (ORR)—was extracted from p

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Gimatdinova, G. R., O. E. Danilova, I. L. Davydkin, R. K. Khairetdinov, and A. V. Antipova. "Genetic polymorphisms associated with the development of arrhythmic type of cardiovascular events." Russian Journal of Cardiology 27, no. 3S (2022): 5069. http://dx.doi.org/10.15829/1560-4071-2022-5069.

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The review analyzes the global agenda on mutational status of genes associated with adverse cardiovascular events of arrhythmic type. Whole exome sequencing will identify a risk group for the likelihood of early or delayed cardiovascular events of arrhythmic type, especially among patients receiving anticancer therapy with cardiotoxic drugs. The dedicated up-to-date panel of genetic polymorphisms will provide an opportunity to optimize management of patients, based on not only clinical, paraclinical and anamnestic data.

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Maeda, Hideki, Riko Shingai, Kentaro Takeda, Asuka Hara, Yuna Murai, and Momoka Ofuchi. "Assessment of Surrogate End Point Trends in Clinical Trials to Approve Oncology Drugs From 2001 to 2020 in Japan." JAMA Network Open 6, no. 4 (2023): e238875. http://dx.doi.org/10.1001/jamanetworkopen.2023.8875.

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ImportanceA surrogate end point (SEP) is an end point used in clinical trials as an alternative for measuring the true clinical benefit. The use of SEPs in trials shortens their duration.ObjectivesTo investigate the use of SEPs in clinical trials to support the approval of anticancer drugs and to determine whether confirmatory studies that use overall survival (OS) as an end point are being conducted in Japan.Design, Setting, and ParticipantsIn this cross-sectional study, drug approvals and background information were obtained from publicly available information, such as the Pharmaceuticals an

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Wagh, Shital* Dr. Prerana Jadhav Dr. Pradyumna Ige. "A Review on Pyranopyrazole as an Antibacterial Agent." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1401–5. https://doi.org/10.5281/zenodo.12773245.

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<strong>Aim: </strong>In our review of various literary works, we have discovered numerous therapeutic properties associated with pyranopyrazole. Additionally, we have postulated that pyranopyrazole may exhibit antibacterial effects.  Pyranopyrazole derivatives are known to have biological significance, such as exhibiting anticancer, analgesic, and anti-inflammatory activities. They are also widely used in biodegradable agrochemicals and pharmaceutical constituents. Due to their applicability, the synthesis of pyranopyrazoles is currently receiving much attention. <strong>Data Source: </s

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Kędra, Karolina, Ewa Oledzka, and Marcin Sobczak. "Self-Immolative Domino Dendrimers as Anticancer-Drug Delivery Systems: A Review." Pharmaceutics 16, no. 5 (2024): 668. http://dx.doi.org/10.3390/pharmaceutics16050668.

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Worldwide cancer statistics have indicated about 20 million new cancer cases and over 10 million deaths in 2022 (according to data from the International Agency for Research on Cancer). One of the leading cancer treatment strategies is chemotherapy, using innovative drug delivery systems (DDSs). Self-immolative domino dendrimers (SIDendr) for triggered anti-cancer drugs appear to be a promising type of DDSs. The present review provides an up-to-date survey on the contemporary advancements in the field of SIDendr-based anti-cancer drug delivery systems (SIDendr-ac-DDSs) through an exhaustive an

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Pavlović, Marijana, Stefan Nikolić, Nevenka Gligorijević, et al. "New organoruthenium compounds with pyrido[2′,3′:5,6] pyrazino[2,3‑f][1, 10]phenanthroline: synthesis, characterization, cytotoxicity, and investigation of mechanism of action." JBIC J Biol Inorg Chem 24, no. 2 (2019): 297–310. https://doi.org/10.1007/s00775-019-01647-4.

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Three new ruthenium(II)-arene complexes with pyrido[2′,3′:5,6]pyrazino[2,3-f][1, 10]phenanthroline (ppf) of general formula: C1 ([(ƞ6-benzene)Ru(ppf)Cl]PF6, C2 ([(ƞ6-toluene)Ru(ppf)Cl]PF6) and C3 ([(ƞ6-p-cymene)Ru(ppf)Cl]PF6) have been synthesized. The structures of complexes were determined by elemental analysis, IR, ESI–MS, as well as with 1H and 13C NMR spectroscopy. Cytotoxic activity has been evaluated in three different human neoplastic cell lines (A549, A375, LS 174T) and in one human non-tumor cell line (MRC-5), by the MTT assay. Complexes C1–C3 showed IC50 valu

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Saadh, Mohamed. "Antiproliferative activity of ruthenium complex II against human cancer cell in vitro." Pharmacia 70, no. (3) (2023): 797–801. https://doi.org/10.3897/pharmacia.70.e111410.

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Despite significant advancements in cancer treatment, there is a constant need for new and effective therapeutic options. One such potential weapon in the fight against cancer is ruthenium complex II. In this article, we synthesized, characterized, and studied the activity of dithiocyanato-N-bis[8-(diphenylphosphino)quinoline]ruthenium (II) [Ru(N-P)2(NCS)2] against MCF-7 human adenocarcinoma cells and the MRC-5 cell lines from fetal lung fibroblast-like cells as normal cells, as well as the mechanisms of action and selectivity. This study demonstrated that [Ru(N-P)<sub>2</sub>(NCS)<sub>2</sub>

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Thangabalan, Boovizhikannan, Kuruba Jagadish, Goswami Mahasweta, and Maddineni Bhavya. "Analytical estimation methods for determination of sorafenib." World Journal of Biology Pharmacy and Health Sciences 12, no. 2 (2022): 016–26. https://doi.org/10.5281/zenodo.7604591.

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Sorafenib is an anticancer drug is used to treat late stage kidney and liver cancer. Sorafenib is used to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). Sorafenib is also used to treat hepatocellular carcinoma (a type of liver cancer) that cannot be treated with surgery and a certain type of thyroid cancer that has spread to other parts of the body and cannot be treated with radioactive iodine. Sorafenib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. Th

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Vijayalakshmi, D., Srinivas Rao Bendi, Motakatla Usharani, and K. Swarna Latha. "Assessment of drug utilization pattern in patients undergoing chemotherapy for various types of metastatic cancers in a tertiary care government hospital." International Journal of Basic & Clinical Pharmacology 9, no. 9 (2020): 1331. http://dx.doi.org/10.18203/2319-2003.ijbcp20203534.

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Background: Cancer is one among main causes of morbidity and mortality in developing and developed countries. The World Cancer Report 2014 of World Health Organization’s (WHO’s) International Agency for Research on Cancer (IARC), states that in 2012 the global incidence of cancer increased to a 14 million new cases, the figure expected to rise to an annual 19.3 million by 2025. The prescription pattern of anticancer drugs has evolved considerably in recent years because of better understanding of underlying pathophysiology of carcinomas as well as introduction of newer drugs. Methods: It was a

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Aniket, Gadale* Disha Fartade. "Synthesis and Antimicrobial Evaluation of 2-Chloromethyl-1H- Benzimidazole Derivative." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 1111–28. https://doi.org/10.5281/zenodo.15606176.

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This study focuses on the synthesis and evaluation of 2-chloromethyl-1H-benzimidazole derivatives for potential pharmacological applications. Subsequent reactions with various nucleophiles, including amines, alcohols, and thiols, afforded a library of diverse benzimidazole derivatives. The synthesized compounds were characterized using spectroscopic techniques such as, infrared (IR) spectroscopy. The purity and structural integrity of the compounds were confirmed, ensuring reliable results for subsequent evaluations. Biological evaluation of the synthesized derivatives was conducted to assess

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Post, Colinda, Hanneke W. M. Van Laarhoven, and Carla Hollak. "Time to access to novel anticancer drugs in Europe, a case study in seven European countries." Journal of Clinical Oncology 40, no. 16_suppl (2022): 1586. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.1586.

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1586 Background: After European Medicines Agency Marketing Authorization (EMA-MA) different national reimbursement processes may contribute to unequal access throughout the EU. The aim of this study is to investigate the access time to new anticancer medicines in seven high-income Northern European countries and factors influencing the reimbursement process. Methods: We performed a retrospective database study. New anticancer medicines were included with a positive CHMP advice between January 2016 and January 2020, leading to EMA-MA followed by an application for national reimbursement approva

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Parchami, Ghazaee, and Kateryna Marchenko-Tolsta. "A REVIEW OF THE ANTICANCER NATURAL PRODUCTS: ALKALOIDS, FLAVONOIDS." Grail of Science, no. 18-19 (September 5, 2022): 391–93. http://dx.doi.org/10.36074/grail-of-science.26.08.2022.62.

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According to the international agency for research on cancer 1 in 5 people develop cancer during their lifetime, suggesting that more than 50 million people are living within five years of a past cancer diagnosis (World Health Organization (WHO, 2020, para. 1). Despite novel approaches like nanomedicine, targeted therapy, and immunotherapy in cancer treatments during the last decades, chemoresistance has remained the chief hurdle in eliminating cancerous cells (Elgendy , Alyammahi & Alhamad, 2020, p. 103095). About 9 out of 10 cancer deaths are due to spreading of cancer cells from the pri

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Kumaresan, R., Khanam M. Azra, and Shaikh Dawood Amanulla Safreen. "Anti-microbial Efficacy of Honey Against Infectious Pathogens." International Journal of Current Pharmaceutical Review and Research 6, no. 5 (2015): 237–39. https://doi.org/10.5281/zenodo.12685854.

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Honey has been known as an ancient traditional medicine, possessing numerous health benefits and recognized for itsantimicrobial, anticancer, and antiulcer property. However, this study was undertaken to evaluate the anti-microbialefficacy of the honey against infectious pathogens. The antimicrobial activity was studied on Escherichia coli,Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis and Aspergillus niger by agar disc diffusion method.Honey was found to effective against Staphylococcus (1.6cm), Escherichia coli (1.9cm), Aspergillus niger (1cm).However, the existing antibiot

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Bimal, K. Banik. "Novel synthesis of β-lactams and their biological evaluation". Journal of Indian Chemical Society Vol. 91, Oct 2014 (2014): 1837–60. https://doi.org/10.5281/zenodo.5733822.

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Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, Texas 78539, USA <em>E-mail </em>: bimalbanik10@gmail.com <em>Manuscript received 30 July 2014, accepted 05 August 2014</em> Stereoselective synthesis of racemic and optically active novel β-lactams using Staudinger cycloaddition reaction with imines and ketenes has been achieved. Microwave induced-reactions have been performed for the preparation of these types of β-lactams and products derived from them. The formation of <em>trans</em>-β-lactams has been rationalized via isomer

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Uchida, Mayako, Yuki Kondo, Shinya Suzuki, and Keiko Hosohata. "Evaluation of Acute Kidney Injury Associated With Anticancer Drugs Used in Gastric Cancer in the Japanese Adverse Drug Event Report Database." Annals of Pharmacotherapy 53, no. 12 (2019): 1200–1206. http://dx.doi.org/10.1177/1060028019865870.

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Background: Development of acute kidney injury (AKI) depends on the severity of renal dysfunction, clinical setting, comorbid factors, and geographical location. Gastric cancer is one of the deadliest malignancies worldwide, and its incidence is significantly high in Japan. Objective: We analyzed the rank-order of the association of anticancer agents for gastric cancer with AKI using a spontaneous reporting system database, the Japanese Adverse Drug Event Report database. Methods: We performed a retrospective pharmacovigilance disproportionality analysis using the adverse event reports submitt

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Sganga, Stefano, Silvia Riondino, Giovanni Maria Iannantuono, Roberto Rosenfeld, Mario Roselli, and Francesco Torino. "Antibody–Drug Conjugates for the Treatment of Renal Cancer: A Scoping Review on Current Evidence and Clinical Perspectives." Journal of Personalized Medicine 13, no. 9 (2023): 1339. http://dx.doi.org/10.3390/jpm13091339.

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Antibody–drug conjugates (ADCs) are complex chemical structures composed of a monoclonal antibody, serving as a link to target cells, which is conjugated with a potent cytotoxic drug (i.e., payload) through a chemical linker. Inspired by Paul Ehrlich’s concept of the ideal anticancer drug as a “magic bullet”, ADCs are also highly specific anticancer agents, as they have been demonstrated to recognize, bind, and neutralize cancer cells, limiting injuries to normal cells. ADCs are among the newest pharmacologic breakthroughs in treating solid and hematologic malignancies. Indeed, in recent years

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Babul, Neog, Sarmah Nabajit, Sinha Sourab, and Kr. Bhattacharyya Pradip. "Density functional based reactivity studies on aziridinium ion intermediates." Journal of Indian Chemical Society Vol. 90, Dec 2013 (2013): 2231–36. https://doi.org/10.5281/zenodo.5794015.

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Department of Chemistry, Arya Vidyapeeth College, Guwahati-781 016, Assam, India <em>E-mail </em>: prdpbhatta@yahoo.com <em>Manuscript received online 08 December 2012, accepted 24 January 2013</em> Reactivities of the aziridinium ion intermediates of six anticancer drugs belonging to the nitrogen mustard family are analysed using conceptual density functional theory based reactivity descriptors. Reactivity of the species is found to depend on dielectric of the solvent. Enthalpy, Gibbs energy and entropy of formation of aziridinium ions are analysed at different temperatures and solvents at 83

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