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Dissertations / Theses on the topic 'Aggregated stem cells'

Author: Grafiati

Published: 3 June 2025

Last updated: 19 July 2025

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1

Sullivan, Denise D. "Incorporation of bio-inspired microparticles within embryonnic stem cell aggregates for directed differentiation." Thesis, Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54909.

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Embryonic stem cells (ESCs) are a unique cell population that can differentiate into all three embryonic germ layers (endoderm, mesoderm, and ectoderm), rendering them an invaluable cell source for studying the molecular mechanisms of embryogenesis. Signaling molecules that direct tissue patterning during embryonic development are secreted by ESC aggregates, known as embryoid bodies (EBs). As many of these signaling proteins interact with the extracellular matrix (ECM), manipulation of the ESC extracellular environment provides a means to direct differentiation. ECM components, such as glycosa

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2

Bratt-Leal, Andrés Miguel. "Biomaterial integration within 3D stem cell aggregates for directed differentiation." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45934.

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The derivation of embryonic stem cells (ESCs) has created an invaluable resource for scientific study and discovery. Further improvement in differentiation protocols is necessary to generate the large number of cells needed for clinical relevance. The goal of this work was to develop a method to incorporate biomaterial microparticles (MPs) within stem cell aggregates and to evaluate their use for local control of the cellular microenvironment for directed differentiation. The effects of unloaded MPs on ESC differentiation were first determined by controlled incorporation of poly(lactic-co-gl

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3

Nguyen, Anh H. "Proteolytically degradable microparticles for engineering the extracellular microenvironment of pluripotent stem cell aggregates." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54845.

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During embryo development, extracellular matrix (ECM) remodeling by matrix metalloproteinases (MMPs) and promotes downstream cell specifications. Pluripotent stem cell (PSC) aggregates can recapitulate various aspects of embryogenesis in vitro, and incorporation of biomaterial microparticles also provides an ideal platform to study cell-biomaterial interactions. Stem cell interactions with ECM-based biomaterials can impact tissue remodeling and differentiation propensity via modulation of MMP activity. This work investigated the MMP activity and subsequent mesenchymal differentiation of embryo

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4

McAlister, William. "Novel size separation techniques for aggregates of embryonic stem cells using the Stokes equation." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/38754/.

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Embryoid body formation is a commonly used procedure in embryonic stem cell differentiation as it recapitulates the early stages of embryogenesis and in doing so induces the formation of the three germ layers. Despite being a commonly used step in the differentiation of embryonic stem cells there is still a raft of inconsistencies in this process. As a result, heterogeneity exists in the cells produced in terms of their number and differentiation status; an issue which must be overcome in order to realise the full potential of embryonic stem cells for regenerative medicine. The work produced h

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5

Garvin, Joshua (Joshua J. ). "Scalable production of cellular aggregates for the differentiation of embryonic stem cells into cardiac muscle." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45793.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2008.<br>Includes bibliographical references (leaves 36-37).<br>Embryonic stem (ES) cells have the potential to treat many diseases, such as heart disease, diabetes, and Parkinson's disease. However, large numbers of desired differentiated or progenitor cells must be generated from ES cells for many regenerative medicine applications to be successful. Current methods of culture used in the laboratory either cannot be scaled-up to produce sufficiently large numbers of cells or do not consistently produce aggr

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6

Baillie-Johnson, Peter. "The generation of a candidate axial precursor in three dimensional aggregates of mouse embryonic stem cells." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267818.

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Textbook accounts of vertebrate embryonic development have been based largely upon experiments on amphibian embryos, which have shown that the tissues of the trunk and tail are organised from distinct precursors that existed during gastrulation. In the mouse and chick, however, retrospective clonal analyses and transplantation experiments have demonstrated that the amniote body instead arises progressively from a population of axial precursors that are common to both the neural and mesodermal tissues of the trunk and tail. For this reason, they are known as neuro-mesodermal progenitors (NMps).

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7

Terrasso, Ana Paula Barreto. "Development of novel human cellular models for neurotoxicity studies." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/8488.

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Dissertation to obtain master degree in Genética Molecular e Biomedicina<br>Information currently available on neurotoxicity of chemicals is scarce and there are a growing number of new compounds to be tested. Therefore, new strategies are necessary to identify neurotoxic agents with speed, reliability and respect for animal welfare. The limited availability of primary human brain cells means that there is a need for human cell lines that reliably model human neurons and astrocytes. Despite the advances in stem cell research, numerous challenges must be overcome before this technology can be

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8

Dang, Phuong Ngoc. "READILY IMPLANTABLE HIGH DENSITY STEM CELL SYSTEMS WITH CONTROLLED GROWTH FACTOR PRESENTATION FROM BIOACTIVE MICROPARTICLES FOR BONE REGENERATION VIA ENDOCHONDRAL OSSIFICATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1421864780.

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9

White, Douglas. "Analyzing multicellular interactions: A hybrid computational and biological pattern recognition approach." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54876.

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Pluripotent embryonic stem cells (ESCs) can differentiate into all somatic cell types, making them a useful platform for studying a variety of cellular phenomenon. Furthermore, ESCs can be induced to form aggregates called embryoid bodies (EBs) which recapitulate the dynamics of development and morphogenesis. However, many different factors such as gradients of soluble morphogens, direct cell-to-cell signaling, and cell-matrix interactions have all been implicated in directing ESC differentiation. Though the effects of individual factors have often been investigated independently, the inherent

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10

Lefebvre, Omar Cynthia. "Défauts intrinsèques de motoneurones spinaux dérivés de cellules souches pluripotentes induites issues d’individus atteints de différentes formes de Sclérose Latérale Amyotrophique." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS507.

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La Sclérose Latérale Amyotrophique (SLA) est une maladie neurodégénérative caractérisée par la mort des motoneurones (MNs). Malgré plusieurs hypothèses pouvant expliquer les mécanismes à l’origine de leur mort sélective, l’hétérogénéité de la SLA rend difficile la compréhension des causes exactes de la dégénérescence. Dans ce contexte, les cellules souches pluripotentes induites humaines (iPSC) permettent l’étude des formes familiales de la maladie comme des formes sporadiques. Contrairement à la majorité des travaux publiés à ce jour qui étudient des iPSC de patients porteurs de mutation dans

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11

Rahman, Muhammad Nafeesur. "Vascular Endothelial Growth Factor Functionalized Agarose Can Efficiently Guide Pluripotent Stem Cell Aggregates Toward Blood Progenitor Cells." Thesis, 2010. http://hdl.handle.net/1807/24626.

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Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the embryo that have great potential for regenerative therapies because of their ability to self-renew and differentiate into almost all cell types. However, this developmental potential is influenced by the local cellular microenvironment, including cell surface bound ligands. In this study, we synthesized an artificial stem cell niche wherein vascular endothelial growth factor A (VEGFA) was functionally immobilized in an agarose hydrogel. Immobilized VEGFA treatments were able to upregulate mesodermal markers, brachyur

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12

Huang, Yu-Hsian, and 黃郁翔. "Transplantation of Islet-Like Cell Aggregates Derived from Umbilical Cord Stromal Mesenchymal Stem Cells to Treat Total Pancreatectomized Pigs." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/93484227398435888318.

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碩士<br>國立陽明大學<br>解剖學及細胞生物學研究所<br>99<br>Summary Objective: Diabetes mellitus is still a problem to yield an effective radical cure in current clinical medicine field. It has been shown that stem cells were not only clinically effective in therapeutic improvement on various diseases but also had the potential to be induced to insulin producing cells. This study was to investigate the functional influence of post-transplanted differentiated islet-like cell aggregates induced from umbilical cord stromal mesenchymal stem cells on the physiological changes and survival rates of total pancreatectomi

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13

Huang, Chieh-Cheng, and 黃玠誠. "A Combination Strategy Using An Antioxidant and Injectable Stem Cell Aggregates for Treating Ischemic Diseases." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/89753271788866213352.

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博士<br>國立清華大學<br>化學工程學系<br>103<br>A recurring obstacle for cell-base strategies in treating ischemic diseases continues to be the significant cell loss during the process of transplantation. Additionally, the recipient microenvironment in the ischemic tissues may confer an elevated state of oxidative stress to the administered cells, thus hindering their adhesion and retention to the therapeutic target, ultimately limiting the scope of therapeutic benefit. In our previous studies, a thermo-responsive methylcellulose (MC) hydrogel system was employed to grow three-dimensional cell aggregates for

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14

Cui, Yifang [Verfasser]. "Functional effects of transplanted embryonic stem cell-derived neural aggregates overexpressing the neural cell adhesion molecule L1 in the MPTP model of Parkinson's disease and in a spinal cord injury model in Mus musculus (Linnaeus, 1758) / vorgelegt von Yifang Cui." 2009. http://d-nb.info/994642849/34.

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15

Hruška-Plocháň, Marián. "Modelování Huntingtonovy choroby a bněčná terapie při poškození míchy." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-322643.

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Neurological disorders affect more than 14% of the population worldwide and together with traumatic brain and spinal cord injuries represent major health, public and economic burden of the society. Incidence of inherited and idiopathic neurodegenerative disorders and acute CNS injuries is growing globally while neuroscience society is being challenged by numerous unanswered questions. Therefore, research of the CNS disorders is essential. Since animal models of the CNS diseases and injuries represent the key step in the conversion of the basic research to the clinics, we focused our work on ge

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