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Journal articles on the topic 'Aging in mass media'
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1
Wadsworth, Laurie A., and Christine P. Johnson. "Mass Media and Healthy Aging." Journal of Nutrition For the Elderly 27, no. 3-4 (September 16, 2008): 319–31. http://dx.doi.org/10.1080/01639360802265863.
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Vitols, Maruta Z., and Caitrin Lynch. "Back in the Saddle Again: Ethics, Visibility, and Aging on Screen." Anthropology & Aging 36, no. 1 (May 22, 2015): 11–19. http://dx.doi.org/10.5195/aa.2015.85.
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This paper engages with filmic portrayals of older adults in the U.S. in order to ask questions about the impacts of mass media on reproducing, critiquing, or interrogating mainstream values and assumptions about aging. The study considers the recent Hollywood works The Expendables (2010) and R.E.D. (2010), as well as the independent documentary Young@Heart (2007). We forefront questions of visibility, invisibility, and recognition both in terms of what experiences and realities are rendered visible or invisible by mass media, but also in terms of the subjective experiences of many older adults in the United States.
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Horst, Tali H., Richard D. Smith, Antje Potthast, and Martin A. Hubbe. "Accelerated Aging of Deacidified and Untreated Book Paper in 1967 Compared with 52 Years of Natural Aging." Restaurator. International Journal for the Preservation of Library and Archival Material 41, no. 3 (October 25, 2020): 131–52. http://dx.doi.org/10.1515/res-2020-0006.
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AbstractThree copies of a book that had been optionally deacidified using two different procedures in 1967, and then subjected to accelerated aging, were tested again after 52 years of natural aging. Matched copies of the book Cooking the Greek Way, which had been printed in Czechoslovakia on acidic paper, were evaluated. Nonaqueous treatment of two of the copies with magnesium methoxide dissolved in chlorofluorocarbon solvent had been found in 1967 to have decreased the susceptibility to embrittlement, as evidenced by the results of the accelerated aging, followed by folding endurance tests. Retesting of the same books in 2019, after 52 years of room temperature storage, showed that the deacidification treatments had achieved the following benefits in comparison to the untreated book: (a) higher brightness; (b) higher folding endurance; (c) tensile breaking length higher in the cross-direction of the paper; (d) substantial alkaline reserve content, (e) an alkaline surface pH in the range 7.1–7.4, and (f) higher molecular mass of the cellulose. Remarkably, some of the folding endurance results matched those of unaged samples evaluated in 1967. Scanning electron micrographs showed no differences between the treated and untreated books.
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Zhang, Shuqiang, Xueyan Lu, Tianyao Zheng, Xiaorui Guo, Qi Chen, and Zhonghua Tang. "Investigation of bioactivities of Taxus chinensis, Taxus cuspidata, and Taxus × media by gas chromatography-mass spectrometry." Open Life Sciences 16, no. 1 (January 1, 2021): 287–96. http://dx.doi.org/10.1515/biol-2021-0032.
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Abstract Taxus species have attracted much attention for their potency in cancer treatment. However, investigating the bioactivities of Taxus species is a complex task, due to their diversity, slow growth, and endangered state. The most important Taxus species in China are Taxus chinensis (T. chinensis), Taxus cuspidata (T. cuspidata), and Taxus × media (T. media), which mainly grow in the northeastern region. This article probes deep into the differences among the leaves of T. chinensis, T. cuspidata, and T. media, with the aid of gas chromatography-mass spectrometry (GC-MS). Through GC-MS, 162 compounds were detected in the samples and found to contain 35 bioactive metabolites. On this basis, 20 metabolites with significant bioactivities (antibiotic, antioxidant, anticancer, and antiaging effects) were identified via unsupervised learning of principal component analysis and supervised learning of partial least squares-discriminant analysis. The results show that T. media has the most prominent antibiotic, antioxidant, and anticancer effects, while T. cuspidata has the most diverse and abundant metabolites that slow down aging.
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van Selm, Martine, and Beatrice I.J.M. Van der Heijden. "Media portrayals of older employees: a success story?" Journal of Organizational Change Management 27, no. 4 (July 8, 2014): 583–97. http://dx.doi.org/10.1108/jocm-05-2014-0102.
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Purpose – The purpose of this paper is to provide an analysis of how portrayals of older employees in mass media messages can help combating stereotypical beliefs on their employability. Design/methodology/approach – The authors conducted a systematic review of empirical studies on mass media portrayals of older employees in order to show what these reveal about the ways in which their employment status, occupation, job type, or work setting is portrayed. The approach builds upon theory on media portrayals, media effects, and stereotypes of older workers’ employability. Findings – This study shows that older employees in media portrayals, when present at all, are relatively often shown in higher-level professional roles, herewith overall, depicting an image that is positive, yet differs from stereotypical beliefs on their employability that are prevalent in working organizations. Research limitations/implications – Further empirical work is needed to more safely conclude on the prevalence of age-related portrayals of work and employment in mass media. In addition, longitudinal research is called for in order to better understand the possible causes for the way in which older employees are portrayed, as well as effects of age-related stereotyping in mass media and corporate communication outlets over time. Practical implications – This research sparks ideas about how new portrayals of older employees in mass media and corporate communication outlets can contribute to novel approaches to managing an aging and multi-generational workforce. Social implications – This study shows how working organizations can make use of the positive and powerful media portrayals of older employees, in order to activate normal and non-ageist behaviors toward them, and herewith, to increase their life-long employability. Originality/value – This study highlights the role of media portrayals of older employees in combating stereotypes about their employability.
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Busetta, Laura. "«Le grandi tardone si difendono»: divismo, sessualità e rappresentazione della maturità femminile." Schermi. Storie e culture del cinema e dei media in Italia 6, no. 10 (December 31, 2021): 17–31. http://dx.doi.org/10.54103/2532-2486/15385.
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This paper focuses on the relationship between cinematic stardom and aging, through the analysis of exemplary figures in in post-World War II Italy. Within a scenario in which sexualization pervades the entire media system, the decline of the star allows us to look at the female body as a mirror of transformations related to gender identities, new mass consumption, generational models, and social norms.
Against this backdrop, the contribution analyses the public discourse on aging which emerges on the pages of the magazine «Oggi», looking particularly at the representation of two emblematic figures: Greta Garbo and Marlene Dietrich.
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Ellwood, Kevin R. J., John Baldwin, and David R. Bauer. "Numerical Model for Nitrogen Tire Inflation5." Tire Science and Technology 35, no. 4 (December 1, 2007): 300–316. http://dx.doi.org/10.2346/1.2802612.
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Abstract The scope of this study was twofold: (1) to quantify the contribution nitrogen inflation would have on oxidative aging of tires and (2) measure the improvement nitrogen tire inflation may have on inflation pressure retention. A previously developed tool for diffusion-limited oxidation was used to simulate aging behavior at 25 and 60 °C. Oven-accelerated tire aging (60 °C) data for different inflation media was used for successful validation of the model, and it was shown that aging rates for higher oxygen concentrations tend toward a constant value. For lower temperatures, the use of nitrogen was shown to produce lower oxygen concentration in the wedge and bead regions of the tire geometry considered when compared to air inflation. By using 95% pure nitrogen (that is, the actual nitrogen concentration in the tire cavity), a 25% reduction in aging rate (for the tire wedge) and a 35% reduction in the initial flux of mass out of the tire (a measure of inflation pressure retention) were calculated.
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Shea, Jeanne L. "Dressing the Older Woman in Post-Mao China: Perspectives from Official Feminist Mass Media and Ordinary Chinese Women." Anthropology & Aging 35, no. 1 (December 1, 2014): 27–52. http://dx.doi.org/10.5195/aa.2014.27.
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This article examines Chinese discourses on dressing the aging female body as a window into the tensions involved in the historical transformation of habitus in early post-Mao China. Drawing on Chinese media articles and ethnographic interviews conducted with Chinese women in their 40s-60s, the analysis compares depictions of new official ideals for older women’s dress that appeared in Chinese government-sponsored feminist media with ordinary older Chinese women’s personal sensibilities about dress. Assessing the applicability of dominant western feminist theories of gender, dress, and age, this article provides a historicized culture-specific application of practice theory, examining older women’s struggles with competing moral logics associated with past and present, and with official media versus personal experience. Overall, it documents experiences of ambivalence and compromise accompanying lifecycle adjustment in embodiment in the context of rapid social change.
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Ellwood, K. R. J., J. Baldwin, and D. R. Bauer. "A Finite Element Model for Oven Aged Tires." Tire Science and Technology 33, no. 2 (April 1, 2005): 103–19. http://dx.doi.org/10.2346/1.2186788.
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Abstract A finite element kinetic model has been developed to interpret issues related to accelerated aging of tires. The model is based on the Basic Autoxidation Scheme and incorporates mass transport limitations related to diffusion of oxygen into the layered elastomer system. The effect of aging on transport properties, such as diffusivity, due to changes in crosslink density is also considered in the model. The extent of oxidation is calculated at different locations within the tire as a function of time, temperature, and inflation media. The extent of oxidation predicted by the model is compared to experimentally derived data such as oxygen content, crosslink density, elongation-to-break, and modulus variation.
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Seals, Douglas R., Christopher A. DeSouza, Anthony J. Donato, and Hirofumi Tanaka. "Habitual exercise and arterial aging." Journal of Applied Physiology 105, no. 4 (October 2008): 1323–32. http://dx.doi.org/10.1152/japplphysiol.90553.2008.
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Aging affects the function and structure of arteries and increases the risk of cardiovascular diseases (CVD). In healthy sedentary adults, aging is associated with increased stiffness (reduced compliance) of large elastic arteries; impaired vascular endothelial function, including reductions in endothelium-dependent dilation (EDD), release of tissue-type plasminogen activator (fibrinolytic capacity) and endothelial progenitor cell number and function; increased intima-media wall thickness (IMT); and peripheral vasoconstriction (decreased basal leg blood flow). Habitual physical activity/increased aerobic exercise capacity is associated with reduced risk of CVD. Compared with their sedentary peers, adults who regularly perform aerobic exercise demonstrate smaller or no age-associated increases in large elastic artery stiffness, reductions in vascular endothelial function, and increases in femoral artery IMT. A short-term, moderate-intensity aerobic exercise intervention (brisk daily walking for 12 wk) improves carotid artery compliance and can restore vascular endothelial function in previously sedentary middle-aged and older adults. Reduced oxidative stress may be an important mechanism contributing to these effects. Habitual resistance exercise increases (high-intensity) or does not affect (moderate-intensity) large elastic artery stiffness, and prevents/restores the age-associated reduction in basal leg blood flow independent of changes in leg fat-free mass. Habitual exercise favorably modulates several expressions of arterial aging, thus preserving vascular function and possibly reducing the risk of CVD.
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Iwarsson, Susanne, Fredrik Brounéus, Knut mårtensson, and Marianne Granbom. "The Housing Experiment: Citizen Science Engaging Older Adults and School Pupils to Assess Housing Accessibility." Innovation in Aging 4, Supplement_1 (December 1, 2020): 820–21. http://dx.doi.org/10.1093/geroni/igaa057.2991.
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Abstract Citizen science is gaining momentum as an approach in many scientific fields. However, it is scarcely used in aging research. Since 2009 in Sweden, Public & Science (NGO) has coordinated an annual mass-experiment where thousands of school pupils have collected data that would have been impossible for researchers to collect on their own. Designed as a cross-generational endeavour, the 2020 mass-experiment, the Housing Experiment, is based on scientific methodology for data collection on housing accessibility. The aim of this presentation is to describe the iterative development process involving older adults, stakeholders in the housing sector, teachers and pupils. We will present the app and instructions developed and piloted for data collection, as well as usability and interrater reliability results. With media attention already in the planning phases, this citizen science initiative has the potential to both generate a unique dataset and increase engagement in housing matters concerning the aging population.
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Broda, Balázs, and György Inzelt. "Studying the effects of bismuth on the electrochemical properties of lead dioxide layers by using the in situ EQCM technique." Journal of Solid State Electrochemistry 24, no. 11-12 (March 30, 2020): 2733–39. http://dx.doi.org/10.1007/s10008-020-04569-3.
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Abstract The charge-discharge characteristics and the aging mechanism of PbO2 layers doped with bismuth in contact with sulfuric acid solutions were studied by using combined cyclic voltammetry and electrochemical quartz crystal microbalance (EQCM) techniques. For this purpose, thick lead dioxide layers (non-doped and doped with Bi) were electrodeposited on gold substrate from aqueous solutions of Pb(NO3)2 dissolved in nitric acid and they were investigated in sulfuric acid media. Based on the electrochemical and the mass change responses, it is concluded that during the electrodeposition, bismuth influences the structure of the PbO2 formed. Bi(III) also inhibits the oxidation of lead sulfate and affects the reduction kinetics of lead dioxide. During successive cyclization (aging), the presence of bismuth accelerates the hydration of PbO2.
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Kruglikova, A. S., I. D. Strajesko, O. N. Tkacheva, D. U. Akasheva, E. V. Plokhova, V. S. Pykhtina, E. V. Dudinskaya, et al. "INTERRELATION BETWEEN CARDIOVASCULAR RISK FACTORS AND TELOMERE BIOLOGY WITH THE SIGNS OF VASCULAR AGING." Cardiovascular Therapy and Prevention 13, no. 3 (June 20, 2014): 11–17. http://dx.doi.org/10.15829/1728-8800-2014-3-11-17.
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Aim.To study interrelationship between cardiovascular risk factors and cellular and vascular aging processes. Material and methods. Totally 136 patients were included having no signs of cardiovascular diseases, diabetes 2nd type and receiving no drug therapy, but with one or several risk factors for cardiovascular diseases (smoking, arterial hypertension, obesity, dyslipidemia, fasting hyperglycemia). The telomere length and telomerase activity was measured by polymerase chain reaction. The thickness of intima-media complex (TIMC) and presence of atherosclerotic plaques (ASP) were measured by duplex scanning of right and left carotid arteries. Pulse wave velocity (PWV) was measured by applanation tonometry. Biochemical tests done by standard.Results.PWV significantly correlated with age, body mass index, glycosilated hemoglobin level, fasting glycemia and telomere length. Presence of ASP and increased TIMC significantly correlated with age, body mass index, arterial hypertension, dyslipidemia.Conclusion.Increase of arterial wall stiffness and subclinical atherosclerotic disease have different causes. The level of PWV more linked with carbohydrate metabolism disorder, and TIMC and ASP are linked with lipid disorders.
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Kukier, Joanna. "Mediatization of Social Reality and Media Experience of Seniors." Mediatization Studies 4 (April 21, 2021): 71. http://dx.doi.org/10.17951/ms.2020.4.71-80.
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<p align="justify"><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span lang="en-GB">The demographic changes taking place in the most developed countries in Europe show a dynamic process of aging societies. Seniors (i.e. according to WHO, people over 65 years of age) are sometimes affected due to the limiting conditions of constantly progressing social changes. One of the most significant transformations is the presence of media in the everyday life of individuals. Development of technology and media communication lead to the spread of the mediatization of social reality. Many media recipients build their idea of the world based on what they learn from the mass media. It then influences their understanding of themselves and their role in the world. The purpose of this article is to analyse mediatization as a social process and to explain how it affects older people's experience of the media.</span></span></span></p>
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Nguyen Lyckeskog, Huyen, Cecilia Mattsson, Lars Olausson, Sven-Ingvar Andersson, Lennart Vamling, and Hans Theliander. "Accelerated aging of bio-oil from lignin conversion in subcritical water." March 2017 16, no. 03 (2017): 123–41. http://dx.doi.org/10.32964/tj16.3.123.
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Accelerated aging of bio-oil derived from lignin was investigated at different aging temperatures (50°C and 80°C) and times (1 hour, 1 day, 1 week, and 1 month). The bio-oil used was produced by the hydrothermal liquefaction of kraft lignin, using phenol as the capping agent, and base (potassium carbonate and potassium hydroxide) and zirconium dioxide as the catalytic system in subcritical water. Elemental composition, molecular weight (by using gel permeation chromatography), and chemical composition (by using gas chromatography–mass spectrometry and 2D nuclear magnetic resonance [18.8 T, DMSO-d6]) of the bio-oil were measured to gain better understanding of the changes that occurred after being subjected to an accelerated aging process. The ligninderived hydrothermal liquefaction bio-oil was quite stable compared with biomass-pyrolysis bio-oil. The yield of the low molecular weight fraction (light oil) decreased from 64.1% to 58.1% and that of tetrahydrofuran insoluble fraction increased from 16.5% to 22.2% after aging at 80°C for 1 month. Phenol and phenolic dimers (Ar–CH2–Ar) had high reactivity compared with other aromatic substituents (i.e., methoxyl and aldehyde groups); these may participate in the polymerization/condensation reactions in the hydrothermal liquefaction bio-oil during accelerated aging. Moreover, the 2D heteronuclear single quantum coherence nuclear magnetic resonance spectra of the high molecular weight fraction (heavy oil) in the aged raw oil in the aromatic region showed that the structure of this fraction was a combination of phenol-alkyl patterns, and the guaiacol cross-peaks of Ar2, Ar5, and Ar6 after aging indicate that a new polymer was formed during the aging process.
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Torgé, Cristina, and Rosita Nyman. "CENTENARIANS IN SWEDISH MASS MEDIA: IS IT REVERSE AGEISM?" Innovation in Aging 6, Supplement_1 (November 1, 2022): 661. http://dx.doi.org/10.1093/geroni/igac059.2438.
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Abstract Studies on ageism often deal with negative stereotypes due to increasing age. Seldom studied is the increase in status that seems to occur at the turning point of 100 years. This study explores how centenarians are portrayed in Swedish media texts and relates this to mechanisms of ageism and age coding. We used Retriever database, which is the biggest Nordic database containing news media, to search for press articles concerning 100- to 105-year-olds. Our search resulted in 1468 articles, consisting of both news articles and feature articles. Excluding articles that did not deal with persons, articles with a paywall and redundant articles resulted in 235 articles. We analyzed (1) the contexts in which centenarians appeared, (2) the relevance of the persons’ age to the event and (3) feelings and values evoked in the articles. On the one hand, news reports evoke how centenarians ought to be shielded from harm and emphasize the indignity of even small wrongdoings. On the other hand, feature articles often use superhuman adjectives to describe centenarians, and emphasize their “youthfulness”. In birthday features, there was also an expectation for centenarians to publicize their celebrations and there was a recurrent trope was that centenarians held well-kept secrets about ageing well. Portrayals of centenarians show that they are an esteemed group. However, we also interpret that these portrayals can hide other forms of ageism, particularly compassionate ageism, and a stereotyping of centenarians that play down ill health and emphasize youthfulness at the extremes of old age.
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Maldonado, Adrián. "The Serialized Past." Advances in Archaeological Practice 4, no. 4 (November 2016): 556–61. http://dx.doi.org/10.7183/2326-3768.4.4.556.
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Maintaining the public’s interest in the past has long been a major concern among archaeologists, and practitioners since Mortimer Wheeler have appreciated the value of reporting their finds through mass media outlets (Moshenska and Schadla-Hall 2011). While teaching the honors module Archaeology in Contemporary Society at the University of Chester in 2015, I wanted to assess the portrayal of our discipline in the news. I put together a computer lab session that collated headlines into word clouds and found some peculiarities of reporting across news sources. Yet when it came time to producing essays, few students chose to write about this subject. While there have been some great studies of archaeology in the media, they are aging fast and new work has yet to catch up with the digital world of online news.
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Gaumet, Jean-Jacques, Gabriel Gaiffe, Clément Dezanet, Stéphane Dalmasso, Pierre Magri, Lavinia Balan, and Raphaël Schneider. "Monitoring the size and the stability of zinc oxide quantum dots in biological media: a soft ionization mass spectrometry technique (MALDI-TOF-MS)." MRS Proceedings 1793 (2015): 7–12. http://dx.doi.org/10.1557/opl.2015.620.
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ABSTRACTWe present herein a joint physical/physico-chemical study and, more specifically, the first application of Matrix Assisted Laser Desorption Ionization coupled with Time of Flight Mass Spectrometry (MALDI-TOF-MS) to analyze small-sized ZnO quantum dots (QDs) (2.8-3.1 nm diameter range) synthesized by sol-gel chemistry and stabilized through an aminosilane coating. A careful investigation of the stability of ZnO QDs was initiated once these dots were dispersed in different media (water, biological buffer) for a period up to 3 weeks. Positive ion mode mass spectra MALDI-TOF-MS combined with optical spectrometry was used to monitor the stability of ZnO QDs when aging. Such a unique combination of MALDI-TOF-MS and physico-chemical techniques is likely to bring new insights into the structure analysis, the stability and consequently the potential toxicity of QDs.
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Marshall, Catherine, Christina Lengyel, and Alphonsus Utioh. "Body Dissatisfaction: Among Middle-aged and Older Women." Canadian Journal of Dietetic Practice and Research 73, no. 2 (July 2012): e241-e241. http://dx.doi.org/10.3148/73.2.2012.e241.
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With the growing pervasiveness of mass media, individuals of all ages and both sexes are bombarded with images that glorify youthfulness, messages that tie self-worth to thinness, and products that promise youth and beauty forever. Aging women are vulnerable to these societal messages and experience strong pressures to maintain their youth and thinness. As the physiological changes that accompany normal aging move these women farther from the “ideal” image, body dissatisfaction may increase. These women are confronted with the impossible task of trying to defy the natural process of aging through a variety of means, including fashion, cosmetics, selective surgeries, and personal food choices. The resulting body image issues, weight preoccupation, and eating disturbances can lead to voluntary food restriction, depression, social withdrawal, lower self-esteem, and disordered eating, all of which can have a negative impact on quality of life and nutritional status. In this review we explore existing research on body dissatisfaction among middle-aged (30 to 60) and older (over 60) women, discuss the prevalence of body dissatisfaction, its predisposing risk factors, and the resulting eating and body maintenance behaviours, and examine implications for dietetic practice.
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Sengupta, Deep, Vera Samburova, Chiranjivi Bhattarai, Adam C. Watts, Hans Moosmüller, and Andrey Y. Khlystov. "Polar semivolatile organic compounds in biomass-burning emissions and their chemical transformations during aging in an oxidation flow reactor." Atmospheric Chemistry and Physics 20, no. 13 (July 16, 2020): 8227–50. http://dx.doi.org/10.5194/acp-20-8227-2020.
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Abstract. Semivolatile organic compounds (SVOCs) emitted from open biomass burning (BB) can contribute to chemical and physical properties of atmospheric aerosols and also may cause adverse health effects. The polar fraction of SVOCs is a prominent part of BB organic aerosols, and thus it is important to characterize the chemical composition and reactivity of this fraction. In this study, globally and regionally important representative fuels (Alaskan peat, Moscow peat, Pskov peat, eucalyptus, Malaysian peat, and Malaysian agricultural peat) were burned under controlled conditions using the combustion chamber facility at the Desert Research Institute (DRI). Gas- and particle-phase biomass-burning emissions were aged in an oxidation flow reactor (OFR) to mimic 5–7 d of atmospheric aging. Fresh and OFR-aged biomass-burning aerosols were collected on Teflon-impregnated glass fiber filters (TIGF) in tandem with XAD resin media for organic carbon speciation. The polar fraction extracted with dichloromethane and acetone was analyzed with gas chromatography mass spectrometry (GC-MS) for 84 polar organic compounds – including mono- and dicarboxylic acids, methoxylated phenols, aromatic acids, anhydrosugars, resin acids, and sterols. For all these compounds, fuel-based emission factors (EFs) were calculated for fresh and OFR-aged samples. The carbon mass of the quantified polar compounds was found to constitute 5 % to 7 % of the total organic compound mass. A high abundance of methoxyphenols (239 mg kg−1 for Pskov peat; 22.6 % of total GC-MS characterized mass) and resin acids (118 mg kg−1 for Alaskan peat; 14.5 % of total GC-MS characterized mass) was found in peat-burning emissions (smoldering combustion). The concentration of some organic compounds (e.g., tetracosanoic acid) with a molecular weight (MW) above 350 g mol−1 decreased after OFR aging, while abundances of low-MW compounds (e.g., hexanoic acid) increased. This indicated a significant extent of fragmentation reactions in the OFR. Methoxyphenols decreased after OFR aging, while a significant increase (3.7 to 8.6 times) in the abundance of dicarboxylic acids emission factors (EFs), especially maleic acid (10 to 60 times), was observed. EFs for fresh and ratios from fresh-to-aged BB samples reported in this study can be used to perform source apportionment and predict processes occurring during atmospheric transport.
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Zhang, Catherine D., Sumitabh Singh, Malavika Suresh, Andreas Ladefoged Ebbehøj, Nathan K. LeBrasseur, Sundeep Khosla, and Irina Bancos. "Impaired Muscle Strength and Performance in Patients With Mild Autonomous Cortisol Secretion." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A85. http://dx.doi.org/10.1210/jendso/bvab048.171.
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Abstract Background: Glucocorticoid-induced myopathy is well-recognized in overt Cushing syndrome (CS), but the impact of mild cortisol secretion on muscle is unclear. Recent data suggest that patients with mild autonomous cortisol secretion (MACS) are frailer and report more weakness than patients with non-functioning adrenal adenomas. We hypothesized that MACS is associated with 1) objective measures of impaired muscle strength and performance and 2) increased tissue accumulation of advanced glycation end products (AGEs), a measure of accelerated aging. Aim: To determine the effect of MACS on muscle mass, strength, performance, and tissue accumulation of AGEs. Methods: We conducted a cross-sectional analysis as part of an ongoing cohort study in patients with MACS compared to age and sex-matched referent subjects without cortisol excess. MACS was defined as serum cortisol >1.8 mcg/dL after the 1 mg overnight dexamethasone suppression test (DST), in the absence of overt signs and symptoms of CS. We measured hand grip strength with hand grip dynamometer and evaluated functional performance on the timed up and go test, 6 minute walk test, and gait speed assessment. Tissue accumulation of AGEs was measured with point-of-care AGE reader. Appendicular lean mass was calculated and adjusted for height in participants who underwent body composition scan. Results: A total of 23 patients with MACS and 23 age and sex-matched referent subjects without cortisol excess were enrolled. The median age of diagnosis was 63 years (range, 51–81), and 26 (56%) were women. In the MACS cohort, median cortisol following 1 mg DST was 2.6 µg/dL (range, 1.9–13.0), median DHEA-S 37 µg/dL (range, 5.0- 141.0), and median ACTH 8.5 pg/mL (range, 5.0–38.0). Patients with MACS had lower hand grip strength (median 29.3 vs. 32.5 kg, p=0.052), slower gait speed (median 1.1 vs. 1.4 m/s, p=0.001), covered less distance during the 6 minute walk test (median 453 vs. 510 m, p=0.001), and took longer to complete the timed up and go test (median 10.1 vs. 8.6 s, p=0.04) than referent subjects without cortisol excess. Accumulation of AGEs was higher in patients with MACS (median 2.9 vs. 2.4, p=0.01). No significant difference was observed in appendicular lean mass (n=19 pairs, 7.8 vs. 7.5 kg/m2, p=0.57). Conclusions: MACS is associated with decreased muscle strength and performance without a significant change in muscle mass, suggesting poor muscle quality. We also observed increased tissue accumulation of AGEs in MACS patients, consistent with our hypothesis of MACS-induced accelerated aging. These findings may help explain the increased frailty observed in MACS, and suggest muscle assessment be considered in all patients with autonomous cortisol secretion. Further studies should examine the impact of muscle and functional impairments on morbidity in MACS, and its possible reversal with either a structured exercise intervention or adrenalectomy.
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Peterson, Matthew J., and Andrew W. Froehle. "ACCELERATED CHILDHOOD SKELETAL AGING IS PROTECTIVE OF DEVELOPMENT OF SARCOPENIA IN LATER LIFE." Innovation in Aging 3, Supplement_1 (November 2019): S608—S609. http://dx.doi.org/10.1093/geroni/igz038.2267.
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Abstract Sarcopenia is an age-related loss of muscle mass and strength that has a multitude of adverse sequelae. Similar to other aging-related phenomenon, sarcopenia is likely the product of inputs that begin in utero and continue throughout the lifespan. We hypothesized that patterns of childhood skeletal growth predict sarcopenia status later in life. Data are from N=202 lifelong participants of the Fels Longitudinal Study (median lifetime visits=33). At the sarcopenia measure visit, participants were aged 65.8 + 10.3 years, 54% female, with body mass index of 27.5 + 4.9. Sarcopenia was defined using published sex-specific cutpoints from dual energy x-ray absorptiometry quantified appendicular lean mass/height2. Childhood skeletal age was calculated from serial hand-wrist radiographs (FELS method). Residual skeletal aging (RSA) was calculated as skeletal age minus predicted chronological age at peak height growth velocity during adolescence. RSA variance was similar in both sexes, with a range of -2 (delayed skeletal aging) to +2 years (accelerated skeletal aging). In older age, 6% of males and 22% of females exhibited sarcopenia. In multivariate logistic regression models controlling for age, self-reported physical activity, and grip strength (all measured at sarcopenia visit), accelerated RSA was protective of sarcopenia (Adjusted OR=0.58; 95% CI: 0.35-0.94). This is the first study to link childhood skeletal maturation to sarcopenia later in life. Biological pathways that explain this association likely include physiological, environmental, and genetic factors that facilitate communication between bone and muscle, and span the life course. Determining their influence is the next important step in this work.
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Zeltser, Arkadi. "The Soviet Belarusian Shtetl: Between Tradition and Modernization in the 1920s and 1930s." Judaic-Slavic Journal, no. 2 (6) (2021): 36–66. http://dx.doi.org/10.31168/2658-3364.2021.2.04.
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In the 1920-1930s, the Soviet policy of transformations, the mass migrations of the Jews (especially the youth) from the towns to the big cities, and the desire of some of the provincial Jews to adopt a modern lifestyle, all had a pronounced effect on the shtetls of Soviet Belorussia. The Jews lost their numerical majority there; they were affected by population aging, and serious changes took place in the employment patterns. At the same time, the process of abandoning the traditional way of life was relatively slow, especially within the framework of the family. If we look at the shtetl as a historical sociocultural phenomenon, we may conclude that it vanished only with the deaths of many of its residents in the Holocaust.
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Vijewardane, Samantha Chandrika, Aindralal Balasuriya, Phyo Kyaw Myint, and Alexandra M. Johnstone. "Determinants of Undernutrition and Associated Factors of Low Muscle Mass and High Fat Mass among Older Men and Women in the Colombo District of Sri Lanka." Geriatrics 7, no. 2 (February 28, 2022): 26. http://dx.doi.org/10.3390/geriatrics7020026.
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Undernutrition is a health challenge due to an expanding older population. The aims of the study were to assess the prevalence and determinants of undernutrition and, associated factors of low muscle and high fat mass among older men and women in the Colombo district of Sri Lanka. A cross sectional study was conducted using a multistage cluster sampling technique. Undernutrition was defined based on anthropometry and body composition assessed using bio-electrical impedance. Sex-specific multivariable logistic regression analyses were conducted. Of 800 participants (30.6% men), 35.3% were undernourished. The factors significantly associated with undernutrition among older women were hypertension with an adjusted odds ratio (aOR) (1.97; 1.36–2.88) and musculoskeletal disabilities aOR (2.19; 1.36–3.53). Among women, age ≥ 70 (1.79; 1.18–3.34) and diabetes (1.77; 1.10–2.84) were associated with low muscle mass and age ≥ 70 (2.05; 1.21–3.47), diabetes (2.20; 1.35–3.59) and disability in chewing (2.39; 1.30–4.40) were associated with high fat mass. Among men, age ≥ 70 years, no/up to grade 5 education, diabetes, visual disability, little/no responsibility in food shopping and not getting nutritional advice from media were associated with reduced odds of low muscle mass and no/up to grade 5 school education, disability in chewing and little/no responsibility in food shopping were associated with reduced odds of high fat mass. Undernutrition among older people is common in Sri Lanka. We have identified key factors associated with low muscle mass and high fat mass in this setting. Given the potential consequences of these conditions, our study provides potential targets for prevention of undernutrition and sarcopenic obesity.
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Rindrasih, Erda. "Media Framing of Disasters and Its Implications for Tourism Industry Policy: Case of Surabaya terrorist attack 2018 and Mt. Agung eruption 2017, Indonesia." Jurnal Humaniora 34, no. 2 (December 19, 2022): 137. http://dx.doi.org/10.22146/jh.75254.
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Tourist destinations worldwide are periodically jeopardised by natural disaster events that threaten tourists’ safety; consequently, the tourism industry is impacted. Mass media has a role to communicate and warn the public about disaster. Media portrayal on disaster events is likely to contribute to the tourism industry recovery and resilience. However, media has played a role in sending a negative message to tourists, making them hesitate to visit the destination. Limited researches have focused on how the media frames disaster events, and how policy makers could intervene. Based on analysis of media coverage of the Surabaya terrorist attack in 2018 and Mt. Agung eruption in 2017, this paper looked at how media framed disaster events and its consequences to the tourism industry policy. A content analysis of mass media from both national and international newspapers of Australia, Malaysia, and Singapore were conducted. The research identified five different framings on the two disasters, including source of problems, impact, solution, responsibility, and adaptive versus maladaptive. Findings also highlights the limited policy response towards these potentially negative media portrayal. Based on these findings, partnership between media and the government should be fostered to encourage post-disaster recovery.
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Telaumbanua, Faudunasokhi, and Salam Irianto Nadeak. "TRAINING SHORT STORY WRITING FOR MASS MEDIA IN THE MIDDLE SCHOOL OF BUDI AGUNG." Jurnal Ilmiah Publipreneur 7, no. 1 (September 4, 2020): 14–18. http://dx.doi.org/10.46961/jip.v7i1.68.
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Literacy cannot be separated from the world of education. Literacy refers to the ability to solve problems and achieve life goals by using text as the primary medium, orally, and in writing. Literacy activities are part of the character education process through reading and writing skills. This means that character education can be obtained through reading and writing, for example, short stories. By reading and writing short stories, it is hoped that Indonesian students will be nurtured to become religious, integrity, nationalist, independent, and have cooperation. Besides, short stories that have been written can be sent to the mass media and become one of the coffers of income for students. On this basis, this community service proposal is aimed at developing a culture of literacy among students as well as building an entrepreneurial spirit by sending short stories to mass media
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Vito, Adli Danu, and Nurly Meilinda. "The Effect of YouTube Effectiveness on Community Population Popularity (Video Study of Da'wah Ustadz Abdul Somad, Lc., MA on the Tafaqquh Channel Videos among the Teenagers in the Mosque Teenager Association Agung (IRMA) Palembang)." Open Access Indonesia Journal of Social Sciences 2, no. 1 (June 12, 2019): 1–12. http://dx.doi.org/10.37275/oaijss.v2i1.11.
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ABSTRACT
Youtube is one of the mass media types of online media that provides information, knowledge, education and entertainment to a wide audience that has considerable appeal compared to other online media. Therefore, some people can gain popularity through YouTube, in this case Ustadz Abdul Somad, Lc., MA, one of the public figures who gained popularity through YouTube with the publication of his lecture videos.
In this study the authors used the theory of effectiveness of mass media by Muhammad Nur Jaya and theory by Rahmat as a benchmark. In the theory of mass media effectiveness there are three dimensions, namely 1) Displaying audio and visuals, 2) Easily accessible, 3) Low cost and popularity theory has three dimensions, including 1) Credibility, 2) Attraction, 3) Power. The results showed that there was a significant influence between the effectiveness of YouTube on the tafaqquh video channel on the popularity of the community leader Ustadz Abdul Somad, Lc., MA among adolescents who were members of the Palembang Grand Mosque Youth Association (IRMA) with a fairly high level of popularity.
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Bygrave, Desiree, and Regina Wright. "Weight Status Influences Carotid Intima-Media Thickness to Executive Function Among Older Adults." Innovation in Aging 4, Supplement_1 (December 1, 2020): 367–68. http://dx.doi.org/10.1093/geroni/igaa057.1183.
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Abstract Carotid atherosclerosis has emerged as an early predictor of reduced cognitive function. Underlying this association are risk factors, such as overweight and obesity, that promote carotid atherosclerosis and poor cognitive outcomes. Given the prevalence of overweight and obesity among older adults, there is a critical need to better understand how atherosclerosis influences cognitive function in the context of elevated weight. To address this gap, the current study examined relations between carotid atherosclerosis (carotid intima-media thickness [IMT]), and attention (Trailmaking Test) and executive function (Verbal Fluency Test) performance, and whether they varied as a function of weight status (body mass index [BMI] classification). Data were analyzed from 162 older adults (mean age = 68.43y, 34% male, 41% African American), free of major disease. Mutliple regression and analysis of variance analyses, adjusted for age, sex, education and mean arterial pressure, showed a statistically significant IMT x BMI interaction for Verbal Fluency performance (p=.04) and a trending IMT x BMI interaction for Trailmaking A performance (p=.05). Simple effects analysis of IMT and Verbal Fluency performance showed that this association was most pronounced among those who are obese. Findings suggest atherosclerosis may influence executive function in the context of obesity among older adults. As the development of carotid atherosclerosis is strongly related to aging, our findings suggest that maintaining a healthy weight may reduce its impact on executive function in older adulthood.
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Zaletel, Lorna Zadravec, Matjaz Popit, and Marjan Zaletel. "Is carotid stiffness a possible surrogate for stroke in long-term survivors of childhood cancer after neck radiotherapy?" Radiology and Oncology 52, no. 2 (February 7, 2018): 136–42. http://dx.doi.org/10.2478/raon-2018-0006.
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Abstract Background The risk for cerebrovascular late effects among childhood cancer survivors is considerable. According to recent studies it is not clear which marker could be reliable for the screening of cerebrovascular diseases among the long-term survivors of childhood cancer. The purpose of this study is to analyse arterial stiffness and intima-media thickness as possible early markers of later occurring stroke in long-term survivors of childhood cancer after neck radiotherapy. Patients and methods Twenty-three patients, treated for Hodgkin disease (HD) in childhood, were included. They had received radiation therapy to the neck with 20–65 (median 30) Gy. Twenty-six healthy controls, matched in age, sex, body mass index, arterial hypertension, smoking history and total cholesterol levels were compared. Highresolution colour-coded duplex sonography and power Doppler sonography of the carotid arteries were performed and intima-media thickness, number and quality of plaques were measured. Arterial stiffness indices were calculated. Results Plaque deposits and/or arterial wall calcinations were found in 24 out of 43 (55.8%) irradiated vessels in cancer survivors group and 0 out of 52 vessels in the group of healthy controls (p < 0.01). We found significant group differences for all the stiffness parameters we used (P < 0.05), but there was no difference in intima-media thickness between cases and controls (p = 0.92). In a multivariate model, carotid pulse wave velocity was positively associated with smoking. Conclusions The arterial stiffness has appeared as a possible surrogate marker for stroke in long-term survivors of childhood cancer. Smoking habit might have an additional negative influence on vascular aging in the group of patients after neck radiotherapy.
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Uotila, Hanna, Kirsi Lumme-Sandt, and Marja Saarenheimo. "Lonely older people as a problem in society – construction in Finnish media." International Journal of Ageing and Later Life 5, no. 2 (January 26, 2011): 103–30. http://dx.doi.org/10.3384/ijal.1652-8670.1052103.
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Loneliness is a prevalent stereotype of old age but there is a lack of studies of how it is represented in mass media. This study examines how the loneliness of older people is portrayed in mass media. The research material consists of 154 texts from the leading 50+ magazines and daily newspapers in Finland. In the texts, loneliness was rarely seen solely as a lack of companionship and many negative attributes were connected to it. Among other things, loneliness was connected to the low status of older people in society, inhumane practices in elderly care, lack of meaning in life and neglect by relatives. Loneliness was also viewed as an inevitable part of ageing. However, many suggestions were made to alleviate loneliness. The extent of these suggestions varied from broad and collective actions to simple and perfunctory solutions.
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Broda, Balázs, and György Inzelt. "Investigation of the electrochemical behaviour of lead dioxide in aqueous sulfuric acid solutions by using the in situ EQCM technique." Journal of Solid State Electrochemistry 24, no. 1 (November 23, 2019): 1–10. http://dx.doi.org/10.1007/s10008-019-04450-y.
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AbstractThe charge-discharge characteristics and the aging mechanism of PbO2 layers in contact with sulfuric acid solutions of different concentrations (1.5–5.0 M) were studied by using combined cyclic voltammetry and electrochemical quartz crystal microbalance (EQCM) techniques. For this purpose, thick lead dioxide layers were electrodeposited on gold substrate from aqueous solutions of Pb(NO3)2 dissolved in nitric acid. Based on the electrochemical and the mass change responses, it was found that in more concentrated solutions of H2SO4, the main reduction reaction was the transformation of lead dioxide to lead sulfate. However, in less concentrated sulfuric acid media, the transformation of lead dioxide to lead(II) ion became the main reaction. These Pb2+ ions transformed into lead sulfate crystals later by a chemical reaction. Because the electrochemical oxidation of lead sulfate is less favourable in sulfuric acid medium of higher concentrations, thus, PbO2 layers cannot be tested by continuous cyclization, which is necessary to study their aging parameters. Therefore, a delay step before each cyclic voltammogram was applied while the non-conductive lead sulfate dissolves or alternatively, by applying a pre-oxidation step prior to each cyclic voltammetry experiment to produce electrochemically significant amount of lead dioxide which can be reduced during the following negative potential sweep.
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Chan, Hui Hsien, and Leng Leng Thang. "Active Aging through Later Life and Afterlife Planning: Shūkatsu in a Super-Aged Japan." Social Sciences 11, no. 1 (December 22, 2021): 3. http://dx.doi.org/10.3390/socsci11010003.
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In Japan, the term shūkatsu—referred as the planning for later life and for the afterlife—has gained popularity due to high amount of mass media exposure in recent years. This paper examines shūkatsu from the active aging framework, contending that shūkatsu is an important activity that contributes to active aging, as the process of conscientious planning encourages older Japanese people to remain active. Data for this study were obtained from qualitative interviews that were conducted with 40 older middle-class Japanese citizens residing in Nagoya. Explored through a life course perspective, the study examined how salient factors, such as personal history, experiences, roles, anxieties, life-changing events, and cultural practices, have influenced older Japanese people in their shūkatsu decision-making process. In the process of understanding how the Japanese respond to changing family relationships and sociocultural transformations, the emphasis on living a “good old age” for better social, psychological, and physical well-being strongly reflects the agency to age actively. In a super-aged Japan, shūkatsu may be a vital strategy that not only ensures a better quality of life for the older population and their children, but it also contributes to individual’s sense of usefulness and satisfaction, as they are actively involved in the planning and management of their own later and afterlife choices.
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Yuk Yee Yan. "Awareness and Knowledge of Andropause Among Chinese Males in Hong Kong." American Journal of Men's Health 4, no. 3 (April 23, 2009): 231–36. http://dx.doi.org/10.1177/1557988309335154.
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This is a pilot study that explored the awareness and knowledge of andropause among Chinese males in Hong Kong. The study employed a structured questionnaire and a convenience sample of 500 individuals at the age ≥40 years participated in the survey. A total of 397 (79.4%) of the respondents were identified as andropause-enlightened, 88.2% of whom believed that andropause was a natural aging process. Mass media was the main source of andropausal information. The andropause-enlightened respondents had poor knowledge with the mean knowledge score of 5.94. The majority identified irritability (72.5%), loss of energy (66.5%), and loss of libido (60.7%) as symptoms. Less than half of the andropause-enlightened respondents expressed that andropause could be treated and only 34 knew testosterone replacement therapy as a treatment. The present findings underscore the need for provision of health education to increase the knowledge of andropause among adult males.
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Purman, Judith R., and Francis R. Gouin. "Influence of Compost Aging and Fertilizer Regimes on the Growth of Bedding Plants, Transplants and Poinsettia." Journal of Environmental Horticulture 10, no. 1 (March 1, 1992): 52–54. http://dx.doi.org/10.24266/0738-2898-10.1.52.
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Abstract Rooted cuttings of poinsettia (Euphorbia pulcherrima Willd. ex Clotzsch ‘Amy’) and seedlings of bibb lettuce (Lactusa sativa L.), baldhead cabbage (Brassica oleracea L. var. Capitata), sweet william (Dianthus barbatus L.) and pansy (Viola & Wittrockiana Gams.) were grown in Sunshine Mix and 7 experimental media containing 30-day-old (“New”) or 90-day-old (“Aged”) cocompost (polymer dewatered sewage sludge composted with processed garbage), perlite or vermiculite, and peatmoss. Plants were fertilized biweekly with water soluble fertilizer of 25N-2.2P-16.6K (25-5-20) at 250 ppm of N applied at 0, 1 or 2 wks after transplanting. The growth of all species did not vary with compost age. Dianthus and pansy plants grown in 50% “New” compost and dianthus grown in 25% “New” compost produced significantly lower top dry mass than those grown in Sunshine Mix. All other treatments for cabbage, lettuce, dianthus and pansy showed no significant difference in top growth from those grown in Sunshine Mix. Poinsettia plants grown in Sunshine Mix produced greater total growth than all other treatments except those grown in equal portions of “New” compost, peat and perlite. Lettuce and cabbage leaf tissue contained cadmium levels less than 0.5 ppm regardless of compost level.
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Jungert, Alexandra, Gerrit Eichner, and Monika Neuhäuser-Berthold. "Trajectories of Body Composition during Advanced Aging in Consideration of Diet and Physical Activity: A 20-Year Longitudinal Study." Nutrients 12, no. 12 (November 25, 2020): 3626. http://dx.doi.org/10.3390/nu12123626.
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This prospective study investigates age-dependent changes in anthropometric data and body composition over a period of two decades in consideration of physical activity and diet in community-dwelling subjects ≥60 years. Overall, 401 subjects with median follow-up time of 12 years were examined. Fat-free mass (FFM) and fat mass (FM) were analyzed using bioelectrical impedance analysis. Physical activity was assessed via a self-administered questionnaire. Dietary intake was examined by 3-day dietary records. Linear mixed-effects models were used to analyze the influence of age, sex, physical activity and energy/protein intake on anthropometric data and body composition by considering year of entry, use of diuretics and diagnosis of selected diseases. At baseline, median values for daily energy and protein intakes were 8.5 megajoule and 81 g and physical activity index was 1.7. After adjusting for covariates, advancing age was associated with parabolic changes indicating overall changes from age 60 to 90 years in women and men in body mass: −4.7 kg, −5.0 kg; body mass index: +0.04 kg/m2, −0.33 kg/m2; absolute FFM: −2.8 kg, −3.5 kg; absolute FM: −1.8 kg, −1.2 kg and waist circumference: +16 cm, +12 cm, respectively. No age-dependent changes were found for upper arm circumference and relative (%) FFM. Dietary and lifestyle factors were not associated with changes in anthropometric or body composition parameters. In summary, the results indicate non-linear age-dependent changes in anthropometric data and body composition, which are largely unaffected by the degree of habitual physical activity and dietary protein intake in well-nourished community-dwelling subjects.
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Khorova, E. A., and A. V. Myshlyavtsev. "Application of hydrogenated butadiene-nitrile rubbers for products operated at high temperatures and in aggressive environments." Voprosy Materialovedeniya, no. 3(95) (January 10, 2019): 129–36. http://dx.doi.org/10.22349/1994-6716-2018-95-3-129-136.
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The subject of the study were rubber mixtures based on hydrogenated butadiene-nitrile rubbers (HNBR) Therban, Zetpol, NBR-B with an acrylonitrile (AN) content of 34% to 49% and unsaturation of 0.9% to 22% with sulfuric, peroxide and sulfuric-peroxide cure systems. The purpose of the study was to determine the effect of the AN content and the degree of unsaturation of HNBR on the properties of rubbers in products designed for operation under the influence of fuels and oils at increased temperatures.The results of the determination of the mass swelling of rubbers in hydrocarbon media and the relative elongation in the process of thermal aging in air and in oil at increased temperatures are presented. The conclusion was made on the use of HNBR mixture with maximum content of AN (49%), with low (6%) and extremely low (0.9%) ODS content and sulfuric peroxide cure system to extend the product service temperature limit to 150°C.
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Mat’at’a, Matej, Helena Galádová, L’udovít Varečka, and Martin Šimkovič. "The study of intracellular and secreted high-molecular-mass protease(s) of Trichoderma spp., and their responses to conidiation stimuli." Canadian Journal of Microbiology 65, no. 9 (September 2019): 653–67. http://dx.doi.org/10.1139/cjm-2018-0670.
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We continued our study of high-molecular-mass proteases (HMMPs) using several strains of the genus Trichoderma, and other filamentous fungi (Botrytis cinerea, Aspergillus niger, Fusarium culmorum, and Penicillium purpurogenum). We found that five Trichoderma strains secreted HMMPs into the media after induction with bovine serum albumin. Botrytis cinerea and F. culmorum secreted proteases in the absence of inducer, while A. niger or P. purpurogenum did not secrete proteolytic activity (PA). The activity of HMMPs secreted by or intracellularly located in Trichoderma spp. represents the predominant part of cellular PA, according to zymogram patterns. This observation allowed the study of HMMPs’ physiological role(s) independent from the secretion. In studying conidiation, we found that illumination significantly stimulated PA in Trichoderma strains. In the T. atroviride IMI 206040 strain, we demonstrated that this stimulation is dependent on the BLR1 and BLR2 receptors. No stimulation of PA was observed when mechanical injury was used as an elicitor of conidiation. Compounds used as inhibitors or activators of conidiation exerted no congruent effects on both PA and conidiation. These results do not favour a direct role of HMMPs in conidiation. Probably, HMMP activity may be involved in the process of the activation of metabolism during vegetative growth, differentiation, and aging-related processes.
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Mirtha, Listya Tresnanti, Angela Tulaar, and I. Dewa Putu Pramantara. "Towards Healthy Aging with Physical Activity and Nutrition." Amerta Nutrition 4, no. 1SP (February 5, 2021): 15. http://dx.doi.org/10.20473/amnt.v4i1sp.2020.15-20.
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Background. Indonesia has become the country with the highest elderly population in Southeast Asia which around 27 million people within 2020. Demographic bonus, where the productive age is higher than the non-productive age, should be optimized so that it becomes an opportunity to decrease the dependency ratio of the elderly over 65 years. However, increasing life expectancy has other implications which as the increase in health problems associated with the aging process, including the emergence of degenerative diseases. The concept of healthy aging formed due to the increase of public awareness to live within quality life and maintaining a healthy lifestyle through physical activity and good nutrition. Healthy aging is the process of developing and maintaining the functional ability that enables wellbeing in older age. Lifestyle improvement from the early stage will have a better effect on a person's lifelong health. Unfortunately, it is not widely known by the public, so awareness is not yet evident and benefits cannot be obtained optimally.Objectives. Healthy aging is the process of developing and maintaining the functional ability that enables wellbeing in older age. The aim of this review is to raise awareness among the adult age group about the important role of physical activity and nutrition in achieving a healthy aging condition.Discussion. American College of Sports Medicine (ACSM) and Centers for Disease Control and Prevention (CDC) recommend adults aged 18–65 year to participate in moderate-intensity aerobic physical activity for a minimum of 30 minutes on five days per week, or vigorous-intensity aerobic activity for a minimum of 20 minutes on three days per week. Moreover, recent WHO (2020) guideline towards physical activity and sedentary behavior recommend all adults to have moderate-intensity for 150 – 300 min or vigorous-intensity for 75 – 150 min per week. But this recommendation has not been able to reduce physical inactivity number in Indonesian society, especially adult and senior adult. There are some nutrition elements related to mobility health, mainly are protein, vitamin D, calcium, antioxidant and omega-3, and many studies report that Indonesian adults suffer deficiencies on these nutrition elements and cause health problems related to mobility. Health interventions should involved many stakeholders, e.g government, private sectors, NGO, mass media, and many more.Conclusions: The concept of healthy aging and interventions related to this need to be recognized and implemented as early as possible to get optimal results, and preferably starting from adulthood. Health interventions carried out must be holistic and synergize between physical activity, nutrition, mental health and other factors that play a role. A community-based approach is the easiest and fastest way to change mindsets and behavior patterns, and can be implemented in the work environment or other communities.
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Huebner, Marianne, Frank Lawrence, and Lara Lusa. "Sex Differences in Age-Associated Rate of Decline in Grip Strength When Engaging in Vigorous Physical Activity." International Journal of Environmental Research and Public Health 19, no. 17 (September 2, 2022): 11009. http://dx.doi.org/10.3390/ijerph191711009.
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Handgrip strength (GS) is used as an indicator of overall muscle strength and health outcomes for aging adults. GS has also been evaluated as a potential link with sport performances. We quantified the age-associated decline in grip strength for males and females engaged in weekly vigorous physical activity, differentiated by body mass, and investigated whether there was an acceleration of decline at any age. The Survey of Health, Ageing and Retirement in Europe is a multinational complex panel data survey with a target population of individuals aged 50 years or older. Data from 48,070 individuals from 20 European countries, collected from 2004 to 2015, were used in multivariable regression models to study the association of age and body weight with grip strength for individuals engaged in vigorous physical activity at least once a week. The annual rate of change in GS differed for males and females; it was constant from ages 50 to 55 years and then accelerated for females, possibly due to the menopausal transition. In contrast, the decline in GS accelerates with each year of increase in age for males. Higher body mass was associated with an increase in GS, but the increase was less pronounced for older males. The increase in GS diminished with a body mass above the median even with engagement in weekly vigorous physical activities. GS reference values for individuals engaged in vigorous physical activity add to existing reference values for general populations.
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Semedov, S. A., and V. A. Sukhareva. "The Greta Thunberg’s Phenomenon and Technology of Mediatization of Ecological Protests." Concept: philosophy, religion, culture, no. 1 (July 7, 2020): 121–38. http://dx.doi.org/10.24833/2541-8831-2020-1-13-121-138.
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This article is devoted to the study of the mediatization technologies, the theatricalization of politics, and the penetration mechanism of mass culture into politics using the example of 2019’s bright phenomenon - Greta Thunberg and her «climate strikes». In this case, various aspects (political, sociopsychological, international, environmental, and ethical) are viewed and need analysis. However, the study of the interaction between the modern information environment and digital natives (generation Z), and the latest tools of modeling mass consciousness is of particular interest. Hybrid forms including elements of mass culture, communication strategies, manipulation technologies, and role-playing avatars present, nowadays, a serious threat to conservative politics. These politics present poorly calculated schemes of latent influence on mass consciousness. «Greta Thunberg - an angry girl in the struggle for the Earth» is a beautiful story, well created and produced with all modern social technologies, efficiently embedded in the world political agenda. A year after its appearance, it is a lever of pressure on high politics, a tool for man aging mass consciousness and a role-playing avatar for young people from 10 to 20 years old and, what’s more, a rooted sociocultural meme. The complexity of the study of this topic is due to the relative freshness of the case, its interdisciplinary character, and most importantly, its incompleteness. The final case can be modeled in different aspects, depending on the creativity of the «producers» behind the project. However, in the heyday of social media «in the global village» such hybrid entities will appear again and again. If, until recently, the most labile and manipulative audience was young people and students, in a short term society may face a «revolution of children» led by Hameln Pied Piper through social networks.
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Dyshlyuk, Lyubov, Anastasiya Fedorova, Anna Loseva, and Natalya Eremeeva. "Callus cultures of Thymus vulgaris and Trifolium pratense as a source of geroprotectors." Food Processing: Techniques and Technology 51, no. 2 (June 15, 2021): 423–32. http://dx.doi.org/10.21603/2074-9414-2021-2-423-432.
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Introduction. Geroprotectors are biologically active substances that inhibit the aging process. Many plant species are natural geroprotectors. For instance, Thymus vulgaris and Trifolium pratense are callus cultures with strong geroprotective properties.
Study objects and methods. The present research featured T. vulgaris and T. pratense grown in vitro on various nutrient media. Their extracts were obtained by aqueous-alcoholic extraction using the following parameters: water-ethanol solvent Se = 30, 50, and 70 %; temperature Te = 30, 50, and 70°C; time τe = 2, 4, and 6 h. The quantitative and qualitative analysis was based on high-performance liquid mass spectrometry, gas mass spectrometry, and thin-layer chromatography.
Results and discussion. The optimal extraction parameters for T. vulgaris were τe = 4 h, Te = 50°C, Se = 70 %, for T. pratense – τe = 6 h, Te = 70°C, Se = 70 %. The chromatography detected flavonoids, phenylpropanoids, simple phenols, higher fatty acids, mono- and sesquiterpenes, and aliphatic hydrocarbons. T. vulgaris appeared to have the highest content of thymol (23.580 ± 1.170 mg/mL); its thymol, apigenin, gallic, chlorogenic, and caffeic components demonstrated geroprotective properties. The extract of T. pratense possessed the highest rutin content (10.05 ± 0.35 mg/mL), and it owed its geroprotective characteristics to rutin, chlorogenic and p-coumaric acids.
Conclusion. The callus cultures of T. vulgaris and T. pratense proved to be promising sources of geroprotective biologically active substances.
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Larkin, Lisa, Eric R. Leiendecker, Mark Supiano, and Jeffrey Halter. "Glucose transporter content and enzymes of metabolism in nerve-repair grafted muscle of aging Fischer 344 rats." Journal of Applied Physiology 83, no. 5 (November 1, 1997): 1623–29. http://dx.doi.org/10.1152/jappl.1997.83.5.1623.
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Larkin, Lisa, Eric R. Leiendecker, Mark Supiano, and Jeffrey Halter. Glucose transporter content and enzymes of metabolism in nerve-repair grafted muscle of aging Fischer 344 rats. J. Appl. Physiol. 83(5): 1623–1629, 1997.—Aging and grafting are associated with decreased ability of muscle to sustain power, likely reflecting diminished fuel availability. To assess mechanisms that may contribute to availability of glucose, we studied GLUT-1 and GLUT-4 protein as well as mRNA contents and enzymes of glucose metabolism in grafted and control medial gastrocnemius (MG) muscles of 6-, 12-, and 24-mo-old male Fischer 344 rats. There was no effect of age or grafting on MG GLUT-4 content. There was both an age- and graft-associated increase in GLUT-1 content ( P = 0.0044 and 0.0063, respectively). There was no effect of aging or grafting on hexokinase and phosphofructokinase activity or on protein and glycogen content. Muscle mass and citrate synthase activity were significantly diminished with grafting. Citrate synthase activity was significantly greater in the 12-mo-old compared with the 6- and 24-mo-old animals. Grafting in combination with aging had no impact on any of the parameters measured. We conclude that diminished glucose transporter expression cannot explain the decreased ability of aged muscle to sustain power. In addition, we conclude that the diminished ability of the grafted MG muscle to sustain power may be explained, in part, by a decrease in energy available from oxidative metabolism.
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Ryan, Joanne, Jo Wrigglesworth, Jun Loong, Peter D. Fransquet, and Robyn L. Woods. "A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age." Journals of Gerontology: Series A 75, no. 3 (April 17, 2019): 481–94. http://dx.doi.org/10.1093/gerona/glz099.
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Abstract DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an individual’s chronological age and can predict their risk of age-related disease and mortality. This study reviewed the evidence that environmental, lifestyle and health factors are associated with the Horvath and Hannum epigenetic clocks. A systematic search identified 61 studies. Chronological age was correlated with DNAm age in blood (median .83, range .13–.99). In a meta-analysis body mass index (BMI) was associated with increased DNAm age (Hannum β: 0.07, 95% CI 0.04 to 0.10; Horvath β: 0.06, 95% CI 0.02 to 0.10), but there was no association with smoking (Hannum β: 0.12, 95% CI −0.50 to 0.73; Horvath β:0.18, 95% CI −0.10 to 0.46). DNAm age was positively associated with frailty (three studies, n = 3,093), and education was negatively associated with the Hannum estimate of DNAm age specifically (four studies, n = 13,955). For most other exposures, findings were too inconsistent to draw conclusions. In conclusion, BMI was positively associated with biological aging measured using DNAm, with some evidence that frailty also increased aging. More research is needed to provide conclusive evidence regarding other exposures. This field of research has the potential to provide further insights into how to promote slower biological aging and ultimately prolong healthy life.
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Shilling, John E., Mikhail S. Pekour, Edward C. Fortner, Paulo Artaxo, Suzane de Sá, John M. Hubbe, Karla M. Longo, et al. "Aircraft observations of the chemical composition and aging of aerosol in the Manaus urban plume during GoAmazon 2014/5." Atmospheric Chemistry and Physics 18, no. 14 (July 30, 2018): 10773–97. http://dx.doi.org/10.5194/acp-18-10773-2018.
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Abstract. The Green Ocean Amazon (GoAmazon 2014/5) campaign, conducted from January 2014 to December 2015 in the vicinity of Manaus, Brazil, was designed to study the aerosol life cycle and aerosol–cloud interactions in both pristine and anthropogenically influenced conditions. As part of this campaign, the U.S. Department of Energy (DOE) Gulfstream 1 (G-1) research aircraft was deployed from 17 February to 25 March 2014 (wet season) and 6 September to 5 October 2014 (dry season) to investigate aerosol and cloud properties aloft. Here, we present results from the G-1 deployments focusing on measurements of the aerosol chemical composition and secondary organic aerosol (SOA) formation and aging. In the first portion of the paper, we provide an overview of the data and compare and contrast the data from the wet and dry season. Organic aerosol (OA) dominates the deployment-averaged chemical composition, comprising 80 % of the non-refractory PM1 aerosol mass, with sulfate comprising 14 %, nitrate 2 %, and ammonium 4 %. This product distribution was unchanged between seasons, despite the fact that total aerosol loading was significantly higher in the dry season and that regional and local biomass burning was a significant source of OA mass in the dry, but not wet, season. However, the OA was more oxidized in the dry season, with the median of the mean carbon oxidation state increasing from −0.45 in the wet season to −0.02 in the dry season. In the second portion of the paper, we discuss the evolution of the Manaus plume, focusing on 13 March 2014, one of the exemplary days in the wet season. On this flight, we observe a clear increase in OA concentrations in the Manaus plume relative to the background. As the plume is transported downwind and ages, we observe dynamic changes in the OA. The mean carbon oxidation state of the OA increases from −0.6 to −0.45 during the 4–5 h of photochemical aging. Hydrocarbon-like organic aerosol (HOA) mass is lost, with ΔHOA∕ΔCO values decreasing from 17.6 µg m−3 ppmv−1 over Manaus to 10.6 µg m−3 ppmv−1 95 km downwind. Loss of HOA is balanced out by formation of oxygenated organic aerosol (OOA), with ΔOOA∕ΔCO increasing from 9.2 to 23.1 µg m−3 ppmv−1. Because hydrocarbon-like organic aerosol (HOA) loss is balanced by OOA formation, we observe little change in the net Δorg∕ΔCO values; Δorg∕ΔCO averages 31 µg m−3 ppmv−1 and does not increase with aging. Analysis of the Manaus plume evolution using data from two additional flights in the wet season showed similar trends in Δorg∕ΔCO to the 13 March flight; Δorg∕ΔCO values averaged 34 µg m−3 ppmv−1 and showed little change over 4–6.5 h of aging. Our observation of constant Δorg∕ΔCO are in contrast to literature studies of the outflow of several North American cities, which report significant increases in Δorg∕ΔCO for the first day of plume aging. These observations suggest that SOA formation in the Manaus plume occurs, at least in part, by a different mechanism than observed in urban outflow plumes in most other literature studies. Constant Δorg∕ΔCO with plume aging has been observed in many biomass burning plumes, but we are unaware of reports of fresh urban emissions aging in this manner. These observations show that urban pollution emitted from Manaus in the wet season forms less particulate downwind as it ages than urban pollution emitted from North American cities.
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Zhang, Yuting, Hang Liu, Shandong Lei, Wanyun Xu, Yu Tian, Weijie Yao, Xiaoyong Liu, et al. "Mixing state of refractory black carbon in fog and haze at rural sites in winter on the North China Plain." Atmospheric Chemistry and Physics 21, no. 23 (December 3, 2021): 17631–48. http://dx.doi.org/10.5194/acp-21-17631-2021.
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Abstract. The variability of the mixing state of refractory black carbon aerosol (rBC) and the corresponding complicated light absorption capacity imposes great uncertainty for its climate forcing assessment. In this study, field observations using a single-particle soot photometer (SP2) were conducted to investigate the mixing state of rBC under different meteorological conditions at a rural site on the North China Plain. The results showed that the hourly mass concentration of rBC during the observation periods was 2.6±1.5 µg m−3 on average, with a moderate increase (3.1±0.9) during fog episodes. The mass-equivalent size distribution of rBC exhibited an approximately lognormal distribution with a mass median diameter (MMD) of 213 nm. We found that the count median diameter (CMD) of rBC particles during snowfall episodes was larger than that before snowfall, and the number of rBC particles with Dc<121 nm were reduced by 28.4 % after snow. This may indicate that rBC-containing particles with small core sizes (Dc) were much more effectively removed by snow with light snow intensity (0.23 mm h−1). Based on the Mie scattering theory simulation, the relative and absolute coating thicknesses of rBC-containing particles were estimated to be ∼1.6 and ∼52 nm for the rBC core with a mass-equivalent diameter (Dc) of 170 to 190 nm, respectively, which indicates that most of the rBC-containing particles were thinly coated. Furthermore, a moderate light absorption enhancement (Eabs=1.3) and relatively low absorption cross section (MAC = 5.5 m2 g−1) at 880 nm were observed at the Gucheng (GC) site in winter compared with other typical rural sites. The relationship between the microphysical properties of rBC and meteorological conditions was also studied. Relatively warm and high-RH environments (RH>50 %, -4∘C<T<4∘C) were more favorable to rBC aging than dry and cold environments (RH<60 %, T<-8∘C). And the increase in ambient RH at the same temperature favors rBC aging. An increasing mass fraction of secondary inorganic aerosols (SIAs; especially sulfate and nitrate) and a decreasing mass fraction of organic aerosols in the environment support the formation of thick coatings by rBC. The RH dependence of absorption enhancement (Eabs) was likely caused by the relative coating thickness (RCT) as supported by the gradual increase in the mass concentration and mass fraction of secondary components as a function of RH in the ambient air. The mass fractions of aqueous-phase formation of secondary components had a limited effect on Eabs under a high-RH environment. The measured rBC concentrations and the mixing state of rBC in different meteorological environments will be useful for evaluating the radiative forcing of rBC in regional climate models.
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Łochyński, Dawid, Maciej Pawlak, Inge Everaert, Tomasz Podgórski, Magdalena Gartych, Anna-Maria Borucka, Jan Celichowski, Wim Derave, and Dominik Kaczmarek. "Motor Unit Fatigability following Chronic Carnosine Supplementation in Aged Rats." Nutrients 14, no. 3 (January 25, 2022): 514. http://dx.doi.org/10.3390/nu14030514.
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Studies suggest that carnosine (beta-alanyl-L-histidine) is effective in treating neuromuscular diseases associated with aging, but there is still a need to clarify its role in motor units (MUs) function during aging. In this study, 40 male Wistar rats aged 15 months were randomly assigned to a control or to two experimental groups in which 0.1% carnosine supplementation was performed for 10 or 34 weeks. After 34 weeks, we examined fast fatigable (FF), fast fatigue-resistant (FR) and slow (S) MUs’ force properties and fatigability, as well as antioxidant potential, advanced glycation end products, activity of enzymes, and histidyl dipeptides content in the medial gastrocnemius muscle. Short- and long-term carnosine supplementation maintained the force of FF MUs at a higher level during its rapid decline seen from the initial 10 to 70 s of the fatigue test. In FF, especially long-term, and in FR MUs, especially short-term, carnosine supplementation resulted in less rapid force decline during the initial 70 s of the second fatigue protocol. Carnosine supplementation did not change muscle antioxidant potential and mortality rate (~35% in all groups), nor muscle mass with aging. Moreover, instead of the expected increase, a decrease in histidyl dipeptides by ~30% in the red portion of medial gastrocnemius muscle after long-term supplementation was found. After chronic carnosine supplementation, the specific changes in fatigue resistance were observed in FF and FR units, but not in S MU types that were not accompanied by an improvement of antioxidant potential and activity of glycolytic or oxidative enzymes in aged rats. These observations indicate that carnosine supplementation during aging may generate different physiological adaptations which should be considered as an important factor when planning treatment strategies.
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Liao, Chun-De, Yen-Tzu Wu, Jau-Yih Tsauo, Pey-Rong Chen, Yu-Kang Tu, Hung-Chou Chen, and Tsan-Hon Liou. "Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials." Nutrients 12, no. 8 (August 12, 2020): 2422. http://dx.doi.org/10.3390/nu12082422.
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Aging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults with lower-limb OA. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) on the effectiveness of PS + ET in older adults with hip or knee OA. Meta-analysis and risk of bias assessment of the included RCTs were conducted. Six RCTs were included in this systemic review; they had a median (range/total) Physiotherapy Evidence Database (PEDro) score of 7 (6–9) out of 10, respectively. Five RCTs that enrolled patients who underwent total joint replacement were included in this meta-analysis. The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, p < 0.00001), pain (SMD = 1.36, p < 0.00001), and muscle strength (SMD = 0.44, p = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement.
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Chu, Shu-Fen, Tsan-Hon Liou, Hung-Chou Chen, Shih-Wei Huang, and Chun-De Liao. "Relative Efficacy of Weight Management, Exercise, and Combined Treatment for Muscle Mass and Physical Sarcopenia Indices in Adults with Overweight or Obesity and Osteoarthritis: A Network Meta-Analysis of Randomized Controlled Trials." Nutrients 13, no. 6 (June 10, 2021): 1992. http://dx.doi.org/10.3390/nu13061992.
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Aging and osteoarthritis are associated with high risk of muscle mass loss, which leads to physical disability; this loss can be effectively alleviated by diet (DI) and exercise (ET) interventions. This study investigated the relative effects of different types of diet, exercise, and combined treatment (DI+ET) on muscle mass and functional outcomes in individuals with obesity and lower-limb osteoarthritis. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) examining the efficacy of DI, ET, and DI+ET in patients with obesity and lower-extremity osteoarthritis. The included RCTs were analyzed through network meta-analysis and risk-of-bias assessment. We finally included 34 RCTs with a median (range/total) Physiotherapy Evidence Database score of 6.5 (4–8/10). DI plus resistance ET, resistance ET alone, and aerobic ET alone were ranked as the most effective treatments for increasing muscle mass (standard mean difference (SMD) = 1.40), muscle strength (SMD = 1.93), and walking speed (SMD = 0.46). Our findings suggest that DI+ET is beneficial overall for muscle mass in overweight or obese adults with lower-limb osteoarthritis, especially those who are undergoing weight management.
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Yunita, Jasrida, Nurlisis Nurlisis, and Wulan Sari. "Determinants of the quality of life among pre-elderly and elderly population." International Journal of Public Health Science (IJPHS) 8, no. 3 (September 1, 2019): 341. http://dx.doi.org/10.11591/ijphs.v8i3.20246.
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<p>Health problems will appear along with the increasing aging of someone that can reduce the quality of life. Many factors can decreases in quality of life. The purpose of this study was to find the determinants of the quality of life to the pre-elderly and elderly population in the working area of Harapan Raya public health center Pekanbaru, Riau, Indonesia. The design of the research was cross sectional in the pre-elderly population (45–59 years) and the elderly population (60 years and above). There were 103 respondents participated in this study gathared with consecutive sampling techniques. Quality of life was measured using WHOQOL SF-36 questionnaire. Independent variables were body mass index, physical activity, chronic disease, smoking behavior, employment status, residence status, marital status, education, age, and sex. Data were analyzed by univariate, bivariate with Chi square test, and multivariate with multiple logistic regression. The proportion of subjects with low quality of life was 18.4%. Variables related to bivariate were body mass index, smoking behavior, chronic disease, employment status, and sex. Chronic disease (OR=5.5; 95% CI=1.173–25.674) significantly affected the quality of life after being controlled by sex. The quality of life could be explained by this factor about 17%. It is necessary to manage chronic diseases in the public health center and provide information to the pre-elderly and the elderly through counseling, print and electronic media.</p>
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Camafeita, Emilio, Inmaculada Jorge, José Rivera-Torres, Vicente Andrés, and Jesús Vázquez. "Quantification of Farnesylated Progerin in Hutchinson-Gilford Progeria Patient Cells by Mass Spectrometry." International Journal of Molecular Sciences 23, no. 19 (October 3, 2022): 11733. http://dx.doi.org/10.3390/ijms231911733.
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Hutchinson-Gilford progeria syndrome (HGPS) is a rare fatal disorder characterized by premature aging and death at a median age of 14.5 years. The most common cause of HGPS (affecting circa 90% of patients) is a de novo heterozygous synonymous single-base substitution (c.1824C>T; p.G608G) in the LMNA gene that results in the accumulation of progerin, an aberrant form of lamin A that, unlike mature lamin A, remains permanently farnesylated. The ratio of progerin to mature lamin A correlates with disease severity in HGPS patients, and can be used to assess the effectiveness of therapies aimed at lessening aberrant splicing or progerin farnesylation. We recently showed that the endogenous content of lamin A and progerin can be measured by mass spectrometry (MS), providing an alternative to immunological methods, which lack the necessary specificity and quantitative accuracy. Here, we present the first non-immunological method that reliably quantifies the levels of wild-type lamin A and farnesylated progerin in cells from HGPS patients. This method, which is based on a targeted MS approach and the use of isotope-labeled internal standards, could be applied in ongoing clinical trials evaluating the efficacy of drugs that inhibit progerin farnesylation.