Academic literature on the topic 'Aging of the lens'

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Journal articles on the topic "Aging of the lens"

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Glasser, Adrian. "Lens Dysfunction through Aging." Ophthalmology 114, no. 3 (March 2007): 618.e1–618.e2. http://dx.doi.org/10.1016/j.ophtha.2006.12.004.

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Hood, Brian D., Brett Garner, and Roger J. W. Truscott. "Human Lens Coloration and Aging." Journal of Biological Chemistry 274, no. 46 (November 12, 1999): 32547–50. http://dx.doi.org/10.1074/jbc.274.46.32547.

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Pokorny, Joel, Vivianne C. Smith, and Margaret Lutze. "Aging of the human lens." Applied Optics 26, no. 8 (April 15, 1987): 1437. http://dx.doi.org/10.1364/ao.26.001437.

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Mohanty, Bimal Prasanna, Soma Bhattacharjee, Prasenjit Paria, Arabinda Mahanty, and Anil Prakash Sharma. "Lipid Biomarkers of Lens Aging." Applied Biochemistry and Biotechnology 169, no. 1 (November 21, 2012): 192–200. http://dx.doi.org/10.1007/s12010-012-9963-6.

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Sharma, K. Krishna, and Puttur Santhoshkumar. "Lens aging: Effects of crystallins." Biochimica et Biophysica Acta (BBA) - General Subjects 1790, no. 10 (October 2009): 1095–108. http://dx.doi.org/10.1016/j.bbagen.2009.05.008.

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Smith, Christine. "Aging Through a Queer Lens." Gerontologist 59, no. 1 (January 9, 2019): 192–93. http://dx.doi.org/10.1093/geront/gny163.

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McMahon, Mary, Craig Forester, and Rochelle Buffenstein. "Aging through an epitranscriptomic lens." Nature Aging 1, no. 4 (April 2021): 335–46. http://dx.doi.org/10.1038/s43587-021-00058-y.

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Faranda, Adam P., Mahbubul H. Shihan, Yan Wang, and Melinda K. Duncan. "The aging mouse lens transcriptome." Experimental Eye Research 209 (August 2021): 108663. http://dx.doi.org/10.1016/j.exer.2021.108663.

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Croft, Mary Ann, Paul L. Kaufman, Kathryn S. Crawford, Michael W. Neider, Adrian Glasser, and Laszlo Z. Bito. "Accommodation dynamics in aging rhesus monkeys." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 275, no. 6 (December 1, 1998): R1885—R1897. http://dx.doi.org/10.1152/ajpregu.1998.275.6.r1885.

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Accommodation, the mechanism by which the eye focuses on near objects, is lost with increasing age in humans and monkeys. This pathophysiology, called presbyopia, is poorly understood. We studied aging-related changes in the dynamics of accommodation in rhesus monkeys aged 4–24 yr after total iridectomy and midbrain implantation of an electrode to permit visualization and stimulation, respectively, of the eye’s accommodative apparatus. Real-time video techniques were used to capture and quantify images of the ciliary body and lens. During accommodation in youth, ciliary body movement was biphasic, lens movement was monophasic, and both slowed as the structures approached their new steady-state positions. Disaccommodation occurred more rapidly for both ciliary body and lens, but with longer latent period, and slowed near the end point. With increasing age, the amplitude of lens and ciliary body movement during accommodation declined, as did their velocities. The latent period of lens and ciliary body movements increased, and ciliary body movement became monophasic. The latent period of lens and ciliary body movement during disaccommodation was not significantly correlated with age, but their velocity declined significantly. The age-dependent decline in amplitude and velocity of ciliary body movements during accommodation suggests that ciliary body dysfunction plays a role in presbyopia. The age changes in lens movement could be a consequence of increasing inelasticity or hardening of the lens, or of age changes in ciliary body motility.
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Chhunchha, Bhavana, Eri Kubo, and Dhirendra P. Singh. "Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6." Cells 9, no. 8 (August 8, 2020): 1861. http://dx.doi.org/10.3390/cells9081861.

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Many disorders of aging, including blinding-diseases, are associated with deficiency of brain and muscle arnt-like protein 1 (Bmal1) and, thereby, dysregulation of antioxidant-defense pathway. However, knowledge is limited regarding the role of Bmal1 regulation of antioxidant-pathway in the eye lens/lens epithelial cells (LECs) at the molecular level. We found that, in aging human (h)LECs, a progressive decline of nuclear factor erythroid 2-related factor 2 (Nrf2)/ARE (antioxidant response element)-mediated antioxidant genes was connected to Bmal1-deficiency, leading to accumulation of reactive oxygen species (ROS) and cell-death. Bmal1-depletion disrupted Nrf2 and expression of its target antioxidant genes, like Peroxiredoxin 6 (Prdx6). DNA binding and transcription assays showed that Bmal1 controlled expression by direct binding to E-Box in Prdx6 promoter to regulate its transcription. Mutation at E-Box or ARE reduced promoter activity, while disruption of both sites diminished the activity, suggesting that both sites were required for peak Prdx6-transcription. As in aging hLECs, ROS accumulation was increased in Bmal1-deficient cells and the cells were vulnerable to death. Intriguingly, Bmal1/Nrf2/Prdx6 and PhaseII antioxidants showed rhythmic expression in mouse lenses in vivo and were reciprocally linked to ROS levels. We propose that Bmal1 is pivotal for regulating oxidative responses. Findings also reveal a circadian control of antioxidant-pathway, which is important in combating lens/LECs damage induced by aging or oxidative stress.
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Dissertations / Theses on the topic "Aging of the lens"

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Bergbauer, Katrina L. "Laser raman spectroscopic studies of ocular lens aging and cataractogenesis." Diss., Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/30031.

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Siik, S. (Seppo). "Lens autofluorescence:in aging and cataractous human lenses. Clinical applicability." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514252675.

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Abstract This study was carried out to investigate in vivo the changes of the human lens autofluorescence (AF) with aging and cataractogenesis. Measurements were performed in the blue-green AF range (495 nm/520 nm) using a fluorometer designed, built and now clinically tested in our department. 43 random eyes of 43 healthy volunteers aged 6-86 years, five of each decade, were studied for effects of aging and 84 eyes of 84 patients with cortical, nuclear, posterior subcapsular or mixed lens opacities were studied for differences of various cataract types. The results were compared with the back light scatter values obtained by the commercially available Interzeag Lens Opacity Meter 701. Also AF and back light scatter of the lens were measured from 122 smoking males aged 57 to 76 years who participated in a cancer prevention study. The results were compared with the widely used subjective lens opacities classification system, LOCS III. In addition data was collected from 30 randomly chosen eyes of as many subjects with varying degrees of yellow-brown lens coloration in an otherwise healthy eye. We studied the influence of lens yellowing expressed by means of lens AF on visibility of retinal nerve fiber layer in black-and-white images. Lens AF profile consists of anterior and posterior peaks and a central plateau. The height of the anterior peak was used as a measure of the maximum AF value. The square root of the ratio between the posterior and the anterior AF peaks was used for estimating the lens transmission. Our technique was highly reproducible. The coefficient of variation was 3.9% for maximum AF and 2.9% for the lens transmission index. Both the maximum AF and light scatter were exponentially increased with age (r = 0.95 and 0.94, respectively; p < 0.0001). According to the regression line of AF begins to increase in early childhood. It appears by extrapolation to be absent at birth. In contrast light scatter in the lens was present even in young children. The lens transmission for blue-green light, determined from the lens AF curve, was almost unchanging with age up to 60 years. Thereafter it decreased rapidly and the interindividual variation increased.In cataractous lenses the mean AF and scatter values differed statistically significantly from those of age matched healthy controls. The highest AF values were measured in nuclear cataracts where AF was also related to visual acuity and an increasing yellow-brown colour of the nucleus. About half of the total variation of the transmission index values could be accounted for by changes in nuclear colour as assessed by the LOCS III grading system. The transmission index provided a more precise prediction about nuclear colour and opalescence than age or light scatter did. In cortical cataracts the AF curve was low and flattened and the maximum AF value was significantly lower than in the age matched control eyes. The highest light scatter values were measured from cortical cataracts, but the correlation between LOCS III cortical grades and light scatter values was rather weak. Posterior subcapsular cataracts cannot be quantified either with AF or with light scatter measurements. Lens yellowing, expressed as lens AF, had an actual effect on retinal nerve fiber layer visibility. AF measurements provided a better prediction about the visibility score than age or visual acuity did. The results of the present study indicate that the lens autofluorescence measurement may be a useful additional tool together with a subjective grading system in the follow-up of optical changes occurring in the nuclear region of the lens.
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Barron, Brent Christian. "Characterization of normal aging and cataractous processes in the eye lens by laser raman spectroscopy." Diss., Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/30052.

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Li, Yi. "Cell proliferation as a biomarker of aging and effect of caloric restriction in mouse lens /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/6328.

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Hawse, John R. "Identification and functional characterization of cataract-specific gene expression changes reveals important pathways for human lens maintenance, aging and disease." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3365.

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Thesis (Ph. D.)--West Virginia University, 2004.
Title from document title page. Document formatted into pages; contains x, 201 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 185-201).
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O'Hanlon, Kelsie C. "Medieval Views on Aging and Their Modern Implications: Analyzing Chaucer's Pardoner Through the Lens of a Second Mirror-Stage." Ohio Dominican University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=odu1512578183523566.

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Mizdrak, Jasminka. "Human lens chemistry: UV filters and age-related nuclear cataract." Australia : Macquarie University, 2007. http://hdl.handle.net/1959.14/16855.

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"A thesis submitted in partial fulfillment of the requirements for the award of the degree of Doctor of Philosophy".
Thesis (PhD) -- Macquarie University, Division of Environmental and Life Sciences, Dept. of Chemistry and Biomolecular Sciences, 2007.
Bibliography: p. 243-277.
Introduction -- A convenient synthesis of 30HKG -- Facile synthesis of the UV filter compounds 30HKyn and AHBG -- Synthesis, identification and quantification of novel human lens metabolites -- Modification of bovine lens protein with UV filters and related metabolites -- Effect of UV light on UV filter-treated lens proteins -- Conclusions and future directions.
The kynurenine-based UV filters are unstable under physiological conditions and undergo side chain deamination, resulting in α,β-unsaturated carbonyl compounds. These compounds can react with free or protein bound nucleophiles in the lens via Michael addition. The key sites of the UV filters kynurenine (Kyn) and 3-hydroxykynurenine (3OHKyn) modification in human lenses include cysteine (Cys), and to a lesser extent, lysine (Lys) and histidine (His) residues. Recent in vivo studies have revealed that 3-hydroxykynurenine-O-β-D-glucoside (3OHKG) binds to Cys residues of lens crystallins in older normal human lenses. As a result of this binding, human lens proteins become progressively modified by UV filters in an age-dependent manner, contributing to changes that occur with the development of age-related nuclear (ARN) cataract. Upon exposure to UV light, free UV filters are poor photosensitisers, however the role of protein-bound species is less clear. It has been recently demonstrated that Kyn, when bound to lens proteins, becomes more susceptible to photo-oxidation by UV light. Therefore, the investigation of 3OHKG binding to lens proteins, and the effect of UV light on proteins modified with 3OHKG and 3OHKyn, were major aims of this study. As a result of the role of these compounds as UV filters and their possible involvement in ARN cataract formation, it is crucial to understand the nature, concentration and modes of action of the UV filters and their metabolites present in the human lenses. Therefore, an additional aim was to investigate human lenses for the presence of novel kynurenine-based human lens metabolites and examine their reactivity.--As 3OHKG is not commercially available, to conduct protein binding studies, an initial aim of this study was to synthesise 3OHKG (Chapter 2). Through the expansion and optimisation of a literature procedure, 3OHKG was successfully synthesised using commercially available and inexpensive reagents, and applying green chemistry principles, where toxic and corrosive reagents were replaced with benign reagents and solvent-free and microwave chemistry was used. A detailed investigation of different reaction conditions was also conducted, resulting in either the improvement of reaction yields or reaction time compared to the literature method. Applying the same synthetic strategy, and using key precursors from the synthesis of 3OHKG, the UV filters 3OHKyn and 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid-O-β-D-glucoside (AHBG), were also successfully synthesised (Chapter 3).
Chapter 4 describes the investigation of both normal and cataractous human lenses in an attempt to identify novel human lens metabolites derived from deaminated Kyn and 3OHKyn (Chapter 4, Part A). Initially, 4-(2-aminophenyl)-4-oxobutanoic acid (AHA), glutathionyl-kynurenine (GSH-Kyn), kynurenine yellow (Kyn yellow), 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid (AHB), glutathionyl-3-hydroxykynurenine (GSH-3OHKyn) and 3-hydroxykynurenine yellow (3OHKyn yellow) were synthesised and human lenses were examined for their presence. AHA and AHB were synthesised from similar precursors to those used in the synthesis of 3OHKG, while the GSH adducts and yellow compounds were synthesised from Kyn and 3OHKyn via base induced deamination. Following isolation and structural elucidation, AHA, AHB and GSH-Kyn were confirmed as novel human lens metabolites. They were quantified in low pmol/mg lens (dry mass) levels in normal and cataractous lenses of all ages, while GSH-3OHKyn, Kyn yellow and 3OHKyn yellow were not detected. In contrast to AHA, the lens metabolites AHB, GSH-Kyn and GSH-3OHKyn were found to be unstable at physiological pH. The spectral properties of these compounds suggest that they may act as UV filters. --Chapter 4 (Part B) also describes the identification and characterisation of a novel human lens UV filter, cysteinyl-3-hydroxykynurenine -O-β-D-glucoside (Cys-3OHKG). An authentic standard was synthesised via Michael addition of cysteine to deaminated 3OHKG. Cys-3OHKG was detected in low pmol/mg lens (dry mass) levels in normal lenses only after the 5th decade of life and was absent in cataractous lenses. Cys-3OHKG showed rapid decomposition at physiological pH.
Chapter 5 describes the identification and quantification of amino acids involved in covalent binding of 3OHKG to lens proteins. Model studies with bovine lens proteins and 3OHKG at pH 7.2 and 9.5 were undertaken. The amino acid adducts were identified via total synthesis and spectral analysis, and subsequently quantified upon acid hydrolysis of the modified lens proteins. Under both pH conditions, 3OHKG was found to react with lens proteins predominantly via Cys residues with low levels of binding also detected at Lys residues. Comparative studies with Kyn (pH 9.5) and 3OHKyn (pH 7.2 and 9.5) resulted in modified lens proteins at Cys residues, with only minor modification at Lys residues at pH 9.5. The extent of modification was found to be significantly higher at pH 9.5 in all cases. His adducts were not identified. 3OHKG-, Kyn- and 3OHKyn-modified lens proteins were found to be coloured and fluorescent, resembling those of aged and ARN cataractous lenses. In contrast, AHB and AHA, which can not form α,β-unsaturated carbonyl compounds, resulted in non-covalent modification of lens proteins. AHB may contribute to lens colouration and fluorescence as further reactions of this material yielded species that have similar characteristics to those identified from 3OHKyn modification. These species are postulated to arise via auto-oxidation of the o-aminophenol moiety present in both 3OHKyn and AHB.--In Chapter 6, the potential roles of 3OHKG and 3OHKyn, and the related species AHA and AHB, in generating reactive oxygen species and protein damage following illumination with UV light was examined. The UV filter compounds were examined in both their free and protein-bound forms. Kyn-modified proteins were used as a positive control. Exposure of these compounds to UV light (λ 305-385 nm) has been shown to generate H2O2 and protein-bound peroxides in a time-dependent manner, with shorter wavelengths generating more peroxides. The yields of peroxides were observed to be highly dependent on the nature of the UV filter compound and whether these species were free or protein bound, with much higher levels being detected with the bound species. Thus, protein-bound 3OHKyn yielded higher levels of peroxide than 3OHKG, with these levels, in turn, higher than for the free UV filter compounds. AHB-treated lens proteins resulted in formation of low but statistically significant levels of peroxides, while AHA-treated lens proteins resulted in insignificant peroxide formation. The consequences of these photochemical reactions have been examined by quantifying protein-bound tyrosine oxidation products (3,4-dihydroxyphenylalanine [DOPA], di-tyrosine [di-Tyr]) and protein cross-linking. 3OHKG-modified proteins gave elevated levels of di-Tyr, but not DOPA, whereas 3OHKyn-modified protein gave the inverse. DOPA formation was observed to be independent of illumination and most likely arose via o-aminophenol auto-oxidation. AHB- and AHA-treated lens proteins resulted in statistically insignificant di-Tyr formation, while a light independent increase in DOPA was observed for both samples. Both reducible (disulfide) and non-reducible cross-links were detected in modified proteins following illumination. These linkages were present at lower levels in modified, but non-illuminated proteins, and absent from unmodified protein samples.
This work has provided an optimised synthetic procedure for 3OHKG and other lens metabolites (Chapters 2 and 3). Four novel lens metabolites have been identified and quantified in normal and cataractous human lenses (Chapter 4). Subsequent experiments, described in Chapter 5, identified the major covalent binding sites of 3OHKG to lens proteins, while AHA and AHB showed non-covalent binding. Further work described in Chapter 6 showed that protein-bound 3OHKG, Kyn and 3OHKyn were better photosensitisers of oxidative damage than in their unbound state. Together, this research has provided strong evidence that post-translational modifications of lens proteins by kynurenine-based metabolites and their interaction with UV light appear, at least in part, responsible for the age-dependent colouration of human lenses and an elevated level of oxidative stress in older lenses. These processes may contribute to the progression of ARN cataract.
Mode of access: World Wide Web.
xxxix, 308 p. ill. (some col.)
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Sparks, Cassandra Renee. "Investigating General Aging Expectations, Self-Perceptions for Aging and Attributions for Aging among Physically Active and Less Active Adults." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20243.

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This thesis, comprising two studies, investigated whether negative expectations and self-perceptions relating to the aging process are associated with less physical activity (Study 1), and whether less active adults are likely to report age as a cause for physical activity failure than more active adults (Study 2). Using Sarkisian et al.’s (2002) Expectations Regarding Aging (ERA-38) survey, Study 1 first developed reliable and valid sub-factors for constructs relating to general aging expectations (GAE) and aging self-perceptions (ASP) by conducting exploratory factor analyses on 167 adults (M age = 59.5). Results revealed three acceptable GAE sub-factors relating to satisfaction/contentment, physical function and cognitive function, and three ASP sub-factors pertaining to functional, social, and sexual health. Subsequent MANOVA analyses showed that active adults reported higher GAE for satisfaction/contentment and cognitive function than less active adults. Regression analyses revealed that physical activity levels positively predicted satisfaction/contentment and physical function expectations among 45-54 yr olds. In Study 2, 177 adults (M age = 60.1) completed our Causal Dimension Scale for Aging (CDSA) and a survey asking whether age was a likely cause of failure in various physical activity contexts. Responses on the CDSA were used to validate ‘General Attributions towards Age’ (GATA), a measure which captured how adults view the aging effects. Subsequent analyses of variance determined that GATA interacted with physical activity status (active, less active) to influence the reported likelihood of age as a cause for failure. Less active adults with stable/uncontrollable GATA reported greater likelihood of age as a cause for failure than all other groups in gym, recreational/community program, and unstructured/spontaneous activity settings. Separate age group analyses indicated that these trends were pronounced in an unstructured/spontaneous activity setting for 45-54 yr olds, and in a generally recently inactive scenario for 55-64 yrs.
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Obrenovich, Mark E. "Investigations Into the Mechanisms of Vitamin C Uptake in Rodent and Human Lens Epithelial Cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1212629235.

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Elkins, Jeananne Sharp. "Diverse facilities, aging residents| Assisted living through the lens of the 2010 National Survey of Residential Care Facilities." Thesis, The Texas A&M University System Health Science Center, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3587509.

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In the late 1980's assisted living emerged as a self-proclaimed new style of providing long-term care and supportive services. Assisted living as espoused by its early proponents and by industry leaders embodied certain specific philosophical tenets, such as dignity, autonomy, meeting scheduled and unscheduled needs and aging in place, in their daily operations. These tenets distinguished assisted living from other forms of institutional care such as nursing home care. In the past twenty years the assisted living industry has matured and grown substantially. However, despite the maturing of the industry and the general agreement on the basic tenets little is known about the degree to which the industry embodies these principles.

In addition public policy and consumer preferences have grown in their focus on substituting assisted living for nursing home care. Moreover, the degree to which assisted living can and does substitute for nursing home care has been largely unexamined. Elder care advocates and researchers have more and more called attention to the increasing acuity level of assisted living residents.

This study consists of three related components, each of which will broaden the understanding of current assisted living facilities and their residents. The first study examines person environment fit in assisted living. Lawton's theory of person environment fit, has largely defined the construction and physical environment of assisted living since the 1980's. Changes in Lawton's theory were proposed by Guiata and Jones in the Journal of the American Medical Association in 2012 in reaction to the increased level of dementia in assisted living residents. A third non-theoretical analysis using exploratory factor is designed assist with development of new constructs in person environment fit theory. The second study examines changes in assisted living facilities and residents from 1999 to 2010. This study uses the only two national surveys of assisted living, The 1999 National Survey of Assisted Living and the 2010 National Survey of Residential Care Facilities. This study will examine both facility level and resident level characteristics to explicate resident acuities and to examine the degree to which facilities are accommodating these acuities. The third study examines facility characteristics associated with discharge of residents from assisted living facilities. Understanding resident discharge from assisted living will give a better understanding how assisted living facilities meet scheduled and unscheduled needs of residents as well as embody the philosophical concept of aging in place.

The contribution of this research is improved understanding of the current assisted living facilities and residents and better understand the importance of facility characteristics in person environment fit and in aging in place. This contribution is significant because assisted living residents are a vulnerable population with no protection under federal statutes and limited protection in most states. If indeed, as advocates and researchers assert, assisted living residents mirror nursing home residents in acuity then this research will assist with developing policies to protect this vulnerable population.

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Books on the topic "Aging of the lens"

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Technogenarians: Studying health and illness through an ageing, science, and technology lens. Chichester: Wiley-Blackwell, 2010.

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Age-related cataract. New York: Oxford University Press, 1991.

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Bob, Morris, ed. The legs are the last to go: Aging, acting, marrying, and other things I learned the hard way. New York: Amistad, 2008.

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Contact lens optics and lens design. 3rd ed. Edinburgh: Elsevier Butterworth-Heinemann, 2006.

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Contact lens optics and lens design. 2nd ed. Oxford: Butterworth-Heinemann, 1995.

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Stephen, Braun, ed. The male biological clock: The startling news about aging, sexuality, and fertility in men. New York: Free Press, 2005.

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Lens design. 3rd ed. New York: Marcel Dekker, 2001.

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Lens design. 4th ed. Boca Raton, FL: CRC Press, 2007.

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Laikin, Milton. Lens design. New York: M. Dekker, 1991.

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Laikin, Milton. Lens design. 2nd ed. New York: Marcel Dekker, Inc., 1995.

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Book chapters on the topic "Aging of the lens"

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Aliò, Jorge L., Alfonso Anania, and Paolo Sagnelli. "The Aging of the Human Lens." In Age-Related Changes of the Human Eye, 61–131. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-507-7_5.

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Hodin, Michael W. "The New Global Economy, through an Aging Lens." In The Upside of Aging, 83–95. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118691823.ch6.

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Ferraro, Kenneth F. "Life Course Lens on Aging and Health." In Handbooks of Sociology and Social Research, 389–406. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20880-0_18.

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Koretz, Jane. "Models of the Lens and Aging Effects." In Models of the Visual System, 57–106. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4757-5865-8_2.

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Harding, John J. "Nonenzymic Posttranslational Modification of Lens Proteins in Aging." In Presbyopia Research, 57–60. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4757-2131-7_7.

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Taylor, Allen. "Effect of photooxidation on the eye lens and role of nutrients in delaying cataract." In Free Radicals and Aging, 266–79. Basel: Birkhäuser Basel, 1992. http://dx.doi.org/10.1007/978-3-0348-7460-1_28.

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Berridge, Clara. "Seeing the Social in Technology for Older Adults: Making the Implicit Explicit Through a Multidisciplinary Lens." In International Perspectives on Aging, 173–89. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8594-5_10.

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Qualls, Sara Honn, and Ashley A. Williams. "Widening the lens and anticipating the future." In Caregiver family therapy: Empowering families to meet the challenges of aging., 191–209. Washington: American Psychological Association, 2013. http://dx.doi.org/10.1037/13943-007.

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Waldegrave, Charles, Marja Aartsen, Ariela Lowenstein, Marjaana Seppänen, Mia Niemi, Maria Gabriella Melchiorre, and Giovanni Lamura. "Conflicting Relations, Abuse and Discrimination Experienced by Older Adults." In International Perspectives on Aging, 119–32. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-51406-8_9.

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AbstractThis chapter brings together three dimensions of negative social relations as they impinge on and are experienced by older people, which have not been addressed together in previous studies. Each dimension, conflictual relationships, abuse and discrimination, is characterised by demeaning social interactions that are important to address when considering social exclusion in ageing societies. Five national studies were carried out in Norway, Finland, Israel, Italy and New Zealand. The studies in each dimension confirmed many of the findings of earlier research that have identified the negative health and social relations associations with each dimension. The three dimensions that are usually studied within their own boundaries are brought together to demonstrate the similar way each reduces the quality of life and social inclusion of older people. They function as exclusionary mechanisms in comparable ways within the social relations domain and have an important place in a conceptual framework of old-age social exclusion. While previous research has focussed on each dimension separately, this lens on the similarities and interrelationships of the three dimensions has enabled a broader understanding of exclusionary mechanisms. It also enables more comprehensive and effective policy formation, than a focus on one dimension at a time.
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Jong, W. W., J. W. M. Mulders, C. E. M. Voorter, G. A. M. Berbers, W. A. Hoekman, and H. Bloemendal. "Post-Translational Modifications of Eye Lens Crystallins: Crosslinking, Phosphorylation and Deamidation." In Advances in Post-Translational Modifications of Proteins and Aging, 95–108. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-9042-8_8.

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Conference papers on the topic "Aging of the lens"

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Sarangi, S., O. Minaeva, J. A. Moncaster, F. Weng, C. Rook, D. Ledoux, J. I. Clark, D. G. Hunter, and L. E. Goldstein. "Monitoring Molecular Aging of Lens Proteins using Noninvasive Quasi-Elastic Light Scattering." In Bio-Optics: Design and Application. Washington, D.C.: OSA, 2015. http://dx.doi.org/10.1364/boda.2015.bm2a.5.

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van der Heijde, G. L., M. Dubbelman, and A. P. A. Beers. "CONTINUOUS ULTRASONOGRAPHIC BIOMETRY (CUB) USED TO MEASURE THICKENING AND TRANSLATION OF THE AGING LENS." In Vision Science and its Applications. Washington, D.C.: OSA, 1999. http://dx.doi.org/10.1364/vsia.1999.sac2.

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Hsu, Y. C., Y. K. Lin, C. C. Tsai, J. H. Kuang, S. B. Huang, H. L. Hu, Y. I. Su, and W. H. Cheng. "Failure Mechanisms Associated with Lens Shape of High-Power LED Modules in Aging Test." In LEOS 2007 - IEEE Lasers and Electro-Optics Society Annual Meeting. IEEE, 2007. http://dx.doi.org/10.1109/leos.2007.4382534.

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Minaeva, O., S. Sarangi, J. A. Moncaster, D. M. Ledoux, C. A. Rook, F. J. Weng, J. I. Clark, D. G. Hunter, and L. E. Goldstein. "In Vivo Assessment of Molecular Aging by Quasi-Elastic Light Scattering in the Human Lens." In Frontiers in Optics. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/fio.2016.jth2a.124.

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Dong, Yi, Shu-sheng Zhang, and Jiang-qi Du. "Accelerated aging test on LEDs life estimation." In International Conference on Optical Instruments and Technology (OIT2011), edited by Larry Weber, Hoi S. Kwok, Yanbing Hou, Lianxiang Yang, Chongxiu Yu, Fengzhou Fang, Albert Weckenmann, Ji Zhao, Peter Zeppenfeld, and Jack Luo. SPIE, 2011. http://dx.doi.org/10.1117/12.906118.

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Keyuan Qian and Zuqiang Guo. "Study of defect density and aging properties of GaN LEDs." In 2013 10th China International Forum on Solid State Lighting (ChinaSSL). IEEE, 2013. http://dx.doi.org/10.1109/sslchina.2013.7177306.

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Stitzel, Joel D., Gail A. Hansen, and Stefan M. Duma. "Modeling Elderly Eye Injuries in Automobile Crashes." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43454.

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Eye injuries have been shown to be greater in the elderly population as a possible cause of this greater incidence. Three separate impact scenarios simulating a foam particle (30 m/s), a streering wheel (15 m/s), and an air bag (67 m/s), were applied to a finite element eye model in order to reveal the effects of aging on the eye when subjected to blunt trauma. The lens stiffness of the model was varied according to human lens stiffness values determined for each age group. The computational eye model demonstrated that increased risk was associated with the increasing stiffness of the lens, producing up to a 120% larger stress in the ciliary body.
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Choi, Hyo-Shik, Jong-In Shim, and Won-Jin Choi. "Influence of current aging on the characteristics of Near-Ultraviolet LEDs." In 2015 11th Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR). IEEE, 2015. http://dx.doi.org/10.1109/cleopr.2015.7376077.

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Huang, Yu-Ming, Kai-Ling Liang, Yu-Yun Cho, Shun-Chieh Hsu, Wei-Hung Kuo, Chung-Ping Huang, Hao-Chung Kuo, Yen-Hsiang Fan, and Chien-Chung Lin. "The Aging Study for Fine Pitch Quantum-Dot Array on LEDs." In CLEO: Science and Innovations. Washington, D.C.: OSA, 2019. http://dx.doi.org/10.1364/cleo_si.2019.sf2o.2.

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Kenji Orita, Hiroshi Ohno, Norio Ikedo, Shinichi Takigawa, and Masaki Yuri. "Increase of nonradiative recombination centers in GaN-based laser diodes during aging." In LEOS 2008 - 21st Annual Meeting of the IEEE Lasers and Electro-Optics Society (LEOS 2008). IEEE, 2008. http://dx.doi.org/10.1109/leos.2008.4688591.

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Reports on the topic "Aging of the lens"

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Krider, J. Lithium Lens Interlocks. Office of Scientific and Technical Information (OSTI), December 1985. http://dx.doi.org/10.2172/948901.

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Primas, Lori Ellen. SQS Fiber Lens Array. Office of Scientific and Technical Information (OSTI), November 2018. http://dx.doi.org/10.2172/1482901.

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Mallett, Michael Wesley. Lens of Eye Dosimetry. Office of Scientific and Technical Information (OSTI), March 2015. http://dx.doi.org/10.2172/1209275.

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Birge, Noah Watson, and Verena Geppert-Kleinrath. MixIT LDRD Lens Design. Office of Scientific and Technical Information (OSTI), June 2020. http://dx.doi.org/10.2172/1633554.

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Weil, David. Population Aging. Cambridge, MA: National Bureau of Economic Research, April 2006. http://dx.doi.org/10.3386/w12147.

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David, Patty. AARP Disrupt Aging Research: Consumer Aging Confidence Study. AARP Research, August 2017. http://dx.doi.org/10.26419/res.00053.001.

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Xue, Liang, and Vincent Fusco. Electronically Reconfigurable Microwave Lens Antennas. Fort Belvoir, VA: Defense Technical Information Center, December 2005. http://dx.doi.org/10.21236/ada445588.

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Marshall, P. The SNAP Strong Lens Survey. Office of Scientific and Technical Information (OSTI), January 2005. http://dx.doi.org/10.2172/839722.

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Seryi, Andrei. Tevatron Electron Lens Magnetic System. Office of Scientific and Technical Information (OSTI), October 2001. http://dx.doi.org/10.2172/798884.

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Andresky, Nikolai L. HAMAS through a Constructivist Lens. Fort Belvoir, VA: Defense Technical Information Center, September 2008. http://dx.doi.org/10.21236/ada510054.

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