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1
Schuhmann, Roland. "Ahd. skruba." Amsterdamer Beiträge zur älteren Germanistik 80, no. 3 (November 24, 2020): 281–85. http://dx.doi.org/10.1163/18756719-12340194.
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Abstract It is shown that the lemma Old High German skruba that is generally found in the dictionaries is a mistake for skuoba and that its meaning is not ‘scrubber’ but rather ‘leather (skin)’ or perhaps ‘scraper’.
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Hahn, M. E., T. A. Gasiewicz, P. Linko, and J. A. Goldstein. "The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice." Biochemical Journal 254, no. 1 (August 15, 1988): 245–54. http://dx.doi.org/10.1042/bj2540245.
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The role of the Ah locus in hexachlorobenzene (HCB)-induced porphyria and the possible involvement of P-450 cytochromes P(1)450 and P(3)450 in the pathogenesis of this disease were investigated in two congenic strains of C57BL/6J mice that differ only at this locus. Female B6-Ahb mice (Ah receptor: approximately 30-70 fmol/mg of cytosolic protein) and B6-Ahd mice (Ah receptor: undetectable) were pretreated with iron (500 mg/kg) and then fed a diet containing 0 or 200 p.p.m. of HCB for up to 17 weeks. Mice from the two strains consumed similar amounts of HCB. Urinary excretion of porphyrins was increased after 7 weeks of HCB treatment in B6-Ahb mice, and after 15 weeks was over 200 times greater than that of mice given iron only. In B6-Ahd mice, porphyrin excretion did not begin to increase until after 13 weeks, and after 15 weeks was only six times greater than that of controls. Similar differences were seen in the 15-week hepatic porphyrin concentrations (B6-Ahb: 1110 +/- 393; B6-Ahd: 17.6 +/- 14.5; controls: approximately 0.20 nmol/g). Uroporphyrinogen decarboxylase (EC 4.1.1.37) activity was diminished by 70 and 20% in B6-Ahb B6-Ahd mice respectively after 15 weeks of treatment with HCB. Cytochromes P(1)450 and P(3)450 were measured in hepatic microsomes (microsomal fractions) by radioimmunoassay and immunoblotting, using antisera raised against the orthologous rat isoenzymes P450c and P450d. HCB induced small amounts of a protein recognized by anti-P450c (P(1)450) in B6-Ahd mice, but not in B6-Ahd mice. Relatively large amounts of a protein recognized by anti-P450d (P(3)450) were induced in both strains, but to a somewhat greater extent in the B6-Ahb mice. The hepatic accumulation of HCB at 15 weeks was greater in B6-Ahb than in B6-Ahd mice, in association with elevated hepatic lipid levels in the former strain. The results of this experiment indicate that the Ah locus influences the susceptibility of C57BL/6J mice to HCB-induced porphyria and are consistent with the suggestion that the sustained induction of P(3)450 and/or P(1)450 may be a causative factor in the development of this disease.
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Schuhmann, Roland. "Ahd. slecko m. ‚Schnecke‘." Amsterdamer Beiträge zur älteren Germanistik 81, no. 1 (May 14, 2021): 1–3. http://dx.doi.org/10.1163/18756719-12340210.
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Abstract Under the forms listed for the lemma Old High German snecko m. ‚snail‘ also a variant ‹ slecco › is mentioned. The ‑l‑ must then be the result either of a scribal error, a dissimilation or an assimilation. However, there is in Dutch a word for snail that also shows ‑l‑, Middle Dutch slecke (f.). It is argued here that Old High German slecko is a separate lemma that corresponds to Middle Dutch slecke.
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Marsden, B. J., V. J. Lieffers, and J. J. Zwiazek. "The effect of humidity on photosynthesis and water relations of white spruce seedlings during the early establishment phase." Canadian Journal of Forest Research 26, no. 6 (June 1, 1996): 1015–21. http://dx.doi.org/10.1139/x26-112.
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Newly transplanted, 3-year-old bare-root white spruce (Piceaglauca (Moench) Voss) seedlings were grown in three levels of absolute humidity difference (AHD), under water-stressed and well-watered conditions in growth chambers. Stomatal conductance to CO2 as well as net assimilation were more than twice as high in the low AHD treatment (6.8 μg H2O•cm−3) as in the high AHD treatment (21.0 μg H2O•cm−3). Transpiration rates were uniform among humidity treatments, but in the low AHD treatment water use efficiency was more than double that of the high AHD treatment. Water use efficiency was greatest in the low AHD conditions, in the water-stressed seedlings, and during the time immediately after planting. There were no differences in the number of new roots produced among humidity treatments, despite the different levels of photosynthesis. In the stress treatment, bud flush of seedlings in the high AHD treatment occurred 3 days later than in the low AHD treatment. A field study on the effects of varying aspen (Populustremuloides Michx.) canopies on humidity levels showed that AHD under partial and full canopies was lower than that of the clearcut. Results suggest that silvicultural treatments that promote higher humidity levels on planting sites should improve white spruce seedling photosynthesis immediately after planting.
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Romeiro, Fernando G., Madileine F. Américo, Fábio S. Yamashiro, Carlos A. Caramori, Arthur O. Schelp, Antonio C. Santos, and Giovanni F. Silva. "Acquired hepatocerebral degeneration and hepatic encephalopathy: correlations and variety of clinical presentations in overt and subclinical liver disease." Arquivos de Neuro-Psiquiatria 69, no. 3 (June 2011): 496–501. http://dx.doi.org/10.1590/s0004-282x2011000400017.
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Acquired hepatocerebral degeneration (AHD) and hepatolenticular degeneration can have similar clinical presentations, but when a chronic liver disease and atypical motor findings coexist, the distinction between AHD and hepatic encephalopathy (HE) can be even more complicated. We describe three cases of AHD (two having HE) with different neuroimaging findings, distinct hepatic diseases and similar motor presentations, all presenting chronic arterial hypertension and weight loss before the disease manifestations. The diagnosis and physiopathology are commented upon and compared with previous reports. In conclusion, there are many correlations among HE, hepatolenticular degeneration and AHD, but the overlapping of AHD and HE could be more common depending on the clinical knowledge and diagnostic criteria adopted for each condition. Since AHD is not considered a priority that affects the liver transplant list, the prognosis in AHD patients remains poor, and flow interruption in portosystemic shunts must always be taken into account.
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Cole, John. "Aid to hairline design (AHD)." International Society of Hair Restoration Surgery 18, no. 5 (September 2008): 173–74. http://dx.doi.org/10.33589/18.5.0173.
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Brown, Nicholas J. L., and James C. Coyne. "Does Twitter language reliably predict heart disease? A commentary on Eichstaedt et al. (2015a)." PeerJ 6 (September 21, 2018): e5656. http://dx.doi.org/10.7717/peerj.5656.
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We comment on Eichstaedt et al.’s (2015a) claim to have shown that language patterns among Twitter users, aggregated at the level of US counties, predicted county-level mortality rates from atherosclerotic heart disease (AHD), with “negative” language being associated with higher rates of death from AHD and “positive” language associated with lower rates. First, we examine some of Eichstaedt et al.’s apparent assumptions about the nature of AHD, as well as some issues related to the secondary analysis of online data and to considering counties as communities. Next, using the data files supplied by Eichstaedt et al., we reproduce their regression- and correlation-based models, substituting mortality from an alternative cause of death—namely, suicide—as the outcome variable, and observe that the purported associations between “negative” and “positive” language and mortality are reversed when suicide is used as the outcome variable. We identify numerous other conceptual and methodological limitations that call into question the robustness and generalizability of Eichstaedt et al.’s claims, even when these are based on the results of their ridge regression/machine learning model. We conclude that there is no good evidence that analyzing Twitter data in bulk in this way can add anything useful to our ability to understand geographical variation in AHD mortality rates.
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Lin, Yen-Sheng, Michael Boninger, Lynn Worobey, Shawn Farrokhi, and Alicia Koontz. "Effects of Repetitive Shoulder Activity on the Subacromial Space in Manual Wheelchair Users." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/583951.
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This study investigated (1) the effect of repetitive weight-relief raises (WR) and shoulder external rotation (ER) on the acromiohumeral distance (AHD) among manual wheelchair users (MWUs) and (2) the relationship between shoulder pain, subject characteristics, and AHD changes. Twenty-three MWUs underwent ultrasound imaging of the nondominant shoulder in an unloaded baseline position and while holding a WR position before and after the WR/ER tasks. Pairedt-tests and Spearman correlational analysis were used to assess differences in the AHD before and after each task and the relationships between pain, subject characteristics, and the AHD measures. A significant reduction in the subacromial space (P<0.01) occurred when subjects performed a WR position compared to baseline. Individuals with increased years of disability had greater AHD percentage narrowing after WR (P=0.008). Increased shoulder pain was associated with AHD percentage narrowing after ER (P≤0.007). The results support clinical practice guidelines that recommend MWUs limit WR to preserve shoulder function. The isolated repetitive shoulder activity did not contribute to the changes of subacromial space in MWUs. The ultrasonographic measurement of the AHD may be a target for identifying future interventions that prevent pain.
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Harput, Gulcan, Hande Guney-Deniz, İrem Düzgün, Uğur Toprak, Lori A. Michener, and Christopher M. Powers. "Active Scapular Retraction and Acromiohumeral Distance at Various Degrees of Shoulder Abduction." Journal of Athletic Training 53, no. 6 (June 1, 2018): 584–89. http://dx.doi.org/10.4085/1062-6050-318-17.
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Context: Performing shoulder-abduction exercises with scapular retraction has been theorized to reduce the potential for shoulder impingement. However, objective data to support this premise are lacking. Objective: To evaluate the influence of active scapular retraction on acromiohumeral distance (AHD) at 4 shoulder-abduction angles using real-time ultrasound. Design: Cross-sectional study. Setting: University laboratory. Patients or Other Participants: Twenty asymptomatic individuals (10 men, 10 women; age = 22.9 ± 2.8 years, height = 169.3 ± 9.5 cm, mass = 65.5 ± 12.9 kg) were recruited. Main Outcome Measure(s): Real-time ultrasound images of AHD were obtained during nonretracted and retracted scapular conditions at 0°, 45°, 60°, and 90° of shoulder abduction. A 2-factor analysis of variance with repeated measures was used to evaluate the influence of shoulder retraction on AHD across shoulder-abduction angles. Results: A scapular-retraction condition × shoulder-abduction–angle interaction for AHD was found (F3,57 = 4.56, P = .006). The AHD was smaller at 0° (10.5 versus 11.2 mm, respectively; t19 = 2.22, P = .04) but larger at 90° (9.4 versus 8.7 mm, respectively; t19 = −2.30, P = .04) of shoulder abduction during the retracted than the nonretracted condition. No differences in AHD were observed between conditions at 45° (t19 = 1.45, P = .16) and 60° (t19 = 1.17, P = .86) of abduction. Conclusions: The observed differences in AHD at 0° and 90° of shoulder abduction were small and did not exceed the established minimal detectable change for either angle. Our findings suggest that active scapular retraction during shoulder abduction has a minimal influence on AHD at 0° and 90° in healthy individuals. Further investigations are needed to determine whether scapular retraction influences AHD in individuals with subacromial impingement.
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Woods, Leslie W., Brant A. Schumaker, Patricia A. Pesavento, Beate M. Crossley, and Pamela K. Swift. "Adenoviral hemorrhagic disease in California mule deer, 1990–2014." Journal of Veterinary Diagnostic Investigation 30, no. 4 (March 27, 2018): 530–37. http://dx.doi.org/10.1177/1040638718766036.
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We reviewed case records from the California Animal Health and Food Safety (CAHFS) laboratory and the California Department of Fish and Wildlife (CDFW) spanning 25 years (1990–2014) for all deer accessions submitted to CAHFS for pathology and/or histopathology, with and without a diagnosis of adenoviral hemorrhagic disease (AHD), in order to determine the prevalence of AHD in California. We also examined spatial and temporal distribution, age, and mule deer subspecies in deer that died from AHD. Of 483 deer submitted to CAHFS for diagnostic testing in 1990–2014, 17.2% were diagnosed with confirmed AHD, and 26.5% were confirmed plus suspected cases of AHD. Columbian black-tailed deer ( Odocoileus hemionus columbianus), particularly fawns and juveniles, were most frequently affected. Deer adenovirus ( Odocoileus adenovirus 1; OdAdV-1) was detected by immunohistochemistry in archived CDFW formalin-fixed, paraffin-embedded tissues from deer that died in mortality events in 1981, 1983, and 1986–1987. OdAdV-1 is a common cause of hemorrhagic disease mortality events in California deer, and mortality as a result of AHD is documented as early as 1981.
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Kadia, Tapan, Farhad Ravandi, Gautam Borthakur, Elias Jabbour, Sherry Pierce, Guillermo Garcia-Manero, Stefan Faderl, Jorge E. Cortes, and Hagop M. Kantarjian. "Incidence, Characteristics, and Outcome of FLT3-ITD Mutations in AML Arising from an Antecedent Hematologic Disorder." Blood 118, no. 21 (November 18, 2011): 2522. http://dx.doi.org/10.1182/blood.v118.21.2522.2522.
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Abstract Abstract 2522 Internal tandem duplication (ITD) mutations in FLT3 (fms-like tyrosine kinase III) are common in acute myeloid leukemia (AML) and are associated with increased relapse risk and adverse outcome. A subset of AML, arising from an antecedent hematologic disorder (AHD) such as myelodysplastic syndrome (MDS), is also associated with an adverse outcome. We sought to review our experience and define the incidence, characteristics, and outcome of FLT3-ITD in AML arising from AHD. We reviewed all cases of newly diagnosed AML, excluding acute promyelocytic leukemia from 2001–2010 at our institution. FLT3-ITD mutational analysis was performed using PCR-based DNA sequencing on 1254 cases. Overall, 187 (15%) patients (pts) had FLT3-ITD mutations. Of the 1254 pts, 545 (43%) were classified as having an AHD and 709 (57%) were not. The incidence of FLT3-ITD in pts with and without AHD was 11% (125/709) and 18% (62/545), respectively (p=0.002). As a separate analysis, among pts who had received any prior chemotherapy or radiation, the incidence of FLT3-ITD was 8% (17/201) vs. 16% (170/1053) in those who had not (p=0.005). Baseline characteristics of the patients with FLT3-ITD positive AML with or without AHD are shown in table 1. The 187 pts with FLT3-ITD were treated with several different therapies as their initial treatment for AML. These included: high dose cytarabine-based (HiDAC) in 131 (70%), conventional dose cytarabine-based in 28 (15%), hypomethylating agents (HMA) in 12 (6%), and other in 16 (9%). The response rates to HiDAC and HMA in each of the two cohorts is shown in table 1. The median overall survival of patients with FLT3-ITD and AHD was 40 weeks vs. 54 weeks in those without AHD (p=0.046, Figure 1). In conclusion, FLT3-ITD is relatively less common in AML arising from AHD and in therapy-related AML compared to de novo AML. AML pts with FLT3-ITD and AHD tend to be older, have a lower bone marrow and peripheral blasts, a lower serum LDH, and significantly shorter overall survival. Compared to those without AHD, the response rate to HiDAC-based therapy in patients with FLT3-ITD and AHD are similar, but the response rates to HMA-based therapy are higher. The role of HMA in the treatment of FLT3-ITD patients with and without AHD should be investigated further.Table 1.Figure 1.Figure 1. Disclosures: No relevant conflicts of interest to declare.
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Gous, M., B. Van Dyk, and E. Bruwer. "Ultrasound comparison of the effects of prehabilitation exercises and the scapular assistance test on the acromiohumeral distance." South African Journal of Sports Medicine 29, no. 1 (November 6, 2017): 1–6. http://dx.doi.org/10.17159/2078-516x/2017/v29i1a3439.
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Background: Prolonged participation in overhead sports creates shoulder muscle imbalances which eventually alter the efficacy of the shoulder stabiliser muscles and heighten injury risk, such as subacromial impingement syndrome. Objectives: The aim of this study was to determine if ultrasound is effective to measure the acromiohumeral distance (AHD) to compare the effect of the scapular assistance test (SAT) on the AHD with a prehabilitative exercise intervention programme in asymptomatic cricket players. Methods: Baseline testing on cricket players from the North- West University cricket squad (N=34) included AHD measurements performed by a sonographer at 0°, 30° and 60° humeral abduction angles respectively, with and without the SAT application. Players were then randomly assigned to an intervention and control group. The control group continued with their normal in-season programme, whereas the intervention group also performed shoulder stability exercises for six weeks. Results: The exercise intervention had a similar effect as the SAT on the AHD at 0o and 30o humeral abduction angles in the intervention group. The AHD measurements in the exercise intervention group indicated widening at all abduction angles after the six-week intervention period, whereas the AHD measurements in the control group were equal or smaller than baseline measurements without the SAT at 30o and 60o respectively. Conclusion: Exercise intervention has a similar effect on the AHD of asymptomatic cricket players compared to the SAT – especially in 0°and 30o of humeral abduction. Ultrasound can therefore be utilised to assist in identifying the risk of developing subacromial impingement syndrome (SIS) in asymptomatic overhead athletes by measuring the AHD at different angles of humeral abduction, without and with the SAT application.
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Chalk, Colin. "The Academic Half-Day in Canadian Neurology Residency Programs." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 31, no. 4 (November 2004): 511–13. http://dx.doi.org/10.1017/s0317167100003735.
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Background:The academic half-day (AHD) appears to have become widespread in Canadian neurology residency programs, but there is little published information about the structure, content, or impact of the AHD.Methods:A written questionnaire was sent to the directors of all active Canadian adult and child neurology residency programs.Results:All 21 program directors responded. An AHD was operating in 15/15 adult and 5/6 child neurology programs. The AHD typically lasts three hours, and occurs weekly, 10 months per year. Most of the weekly sessions are lectures or seminars, usually led by clinicians, with about 90% resident attendance. Course-like features (required textbook, examinations) are present in many AHDs. There is a wide range of topics, from disease pathophysiology to practice management, with considerable variation between programs.Conclusion:Almost all Canadian neurology programs now have an AHD. Academic half-days are broadly similar in content and format across the country, and residents now spend a substantial portion of their training attending the AHD. The impact of the AHD on how residency programs are organized, and on the learning, clinical work, and professional development of residents merits further study.
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Stel’makh, A. U. "Adhesion-hydrodynamic (AHD) model of friction." Journal of Friction and Wear 35, no. 4 (July 2014): 316–26. http://dx.doi.org/10.3103/s1068366614040102.
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Cooke, N. E., B. K. Jones, A. Misra-Press, M. Urbanek, J. E. Russell, and S. A. Liebhaber. "PLACENTAL GROWTH HORMONE AHD RELATED PROTEINS." Pediatric Research 33 (May 1993): S7. http://dx.doi.org/10.1203/00006450-199305001-00030.
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Stead, Jim, and Stephen Holtznagel. "AHD Heights from GPS Using Ausgeoid93." Australian Surveyor 39, no. 1 (March 1994): 21–27. http://dx.doi.org/10.1080/00050326.1994.10558404.
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Grossnickle, Steven C., and Terence J. Blake. "Environmental and physiological control of needle conductance for bare-root black spruce, white spruce, and jack pine seedlings on boreal cutover sites." Canadian Journal of Botany 64, no. 5 (May 1, 1986): 943–49. http://dx.doi.org/10.1139/b86-126.
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A study was conducted to examine the influence of environmental conditions of boreal cutover sites on plant water status and needle conductance of newly planted bare-root black spruce (Picea mariana (Mill.) B.S.P.), white spruce (Picea glauca (Moench) Voss.), and jack pine (Pinus banksiana Lamb.) seedlings. As absolute humidity deficit between the needles and air (AHD) increased, xylem pressure potentials (ψx) became most negative in black spruce, intermediate in white spruce, and least negative in jack pine seedlings. Needle conductance (gwv) was strongly related to AHD in all three species, with increasing AHD resulting in a decrease in gwv. However, at low levels of AHD, gwv values for black and white spruce seedlings were approximately 50 and 25% higher, respectively, than those for jack pine seedlings. For black and white spruce seedlings, gwv decreased as ψx became more negative, while jack pine gwv responded to more negative ψx with a threshold for stomatal closure at approximately −1.7 MPa. In all three species, increasing photosynthetically active radiation (PAR) resulted in greater gwv at all AHD levels. However, at high AHD levels, gwv, response to PAR was suppressed. The findings of this study indicate species differences in physiological response to atmospheric conditions under nonlimiting soil moisture conditions. The implications for successful reforestation are discussed.
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Schmidt, Simon Vadstrup, Jannik Andersen Engelhardt, Ann Cools, Stig Peter Magnusson, and Christian Couppé. "Acromio-Humeral Distance Is Associated with Shoulder External Strength in National Elite Badminton Players—A Preliminary Study." Sports 9, no. 4 (March 31, 2021): 48. http://dx.doi.org/10.3390/sports9040048.
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Purpose: To examine acromio-humeral distance (AHD) and shoulder isometric strength for external rotation (ER) and internal rotation (IR) in national elite badminton players. Methods: Seven elite badminton players with asymptomatic shoulders aged 24 ± 4 (mean ± SD) from the Danish national badminton team were investigated. Shoulder AHD, isometric strength in ER and IR were bilaterally assessed with ultrasonography and a hand-held dynamometer (HHD). Results: AHD was greater on the dominant vs. the nondominant side (p = 0.018). Moreover, IR strength was greater on the dominant side vs. the nondominant side (p = 0.041). Furthermore, AHD and ER strength were highly correlated on the dominant side (p = 0.007, r = 0.900). A correlation was also shown between AHD and the ER/IR strength ratio on the dominant side (p = 0.033, r = 0.793). Conclusion: This preliminary study demonstrates that shoulder ER strength is strongly associated with AHD size, largely reflecting supraspinatus tendon-muscle hypertrophy as a result of sport-specific adaptation in national elite badminton players with asymptomatic shoulders. These novel data also suggest that habitual loading of the shoulder improves the supraspinatus tendon size, which may lower the mechanical stress and potentially reduce the risk of injury. This warrants strengthening the shoulder external rotators as a potential strategy to reduce the risk of future shoulder injury.
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LeVasseur, Clarissa, Jonathan Hughes, Adam Popchak, James Irrgang, William Anderst, Albert Lin, and Gillian Kane. "Motion, and Patient-Reported Outcomes." Orthopaedic Journal of Sports Medicine 9, no. 7_suppl4 (July 1, 2021): 2325967121S0024. http://dx.doi.org/10.1177/2325967121s00246.
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Objectives: Patients with irreparable rotator cuff tears (RCT) exhibit functional limitations believed to be caused by superior migration of the humerus1,2. One viable treatment is superior capsule reconstruction (SCR). SCR has been shown to restore stability of the glenohumeral (GH) joint in cadavers1, but its effectiveness at controlling in vivo humeral motion is unknown. Outcomes are typically evaluated through standard clinical radiographs to assess acromial-humeral distance (AHD), and patient-reported outcomes (PROs) such as ASES and Visual Analog Scale3. Reported changes in AHD are inconsistent, with some studies reporting an increase in AHD of 2.6 to 3.2 mm4,5, while other studies reported no significant change in AHD after SCR6,7. Additionally, AHD does not account for anterior-posterior translations of the humeral head and clinical radiographs cannot assess dynamic translation of the humerus during arm abduction. The aim of this study was to determine the in vivo effect of SCR on in vivo glenohumeral arthrokinematics during scapular abduction, and to compare these results to PROs. We hypothesized that static and dynamic AHD would increase, humeral head location on the glenoid would be more inferior at corresponding abduction angles after SCR, and changes in humeral head translation or AHD would correlate with increased GH abduction range of motion and improved PROs. Methods: Ten patients (8M, 2F, age 63 ± 7 years) with irreparable RCT provided informed consent to participate in this prospective IRB-approved study. ASES, DASH, and WORC surveys were completed before (PRE) and 1-year (1YR-POST) after SCR. Synchronized biplane radiographs of the shoulder were collected PRE and 1YR-POST at 50 images/s while patients performed 3 trials of scapular plane arm abduction. Biplane radiographs were also collected during a static neutral trial where the participants placed their hand on their lap. Six degree of freedom GH and scapular kinematics were determined with sub-millimeter accuracy by matching subject-specific CT-based bone models of the humerus and scapula to radiographs using a validated volumetric tracking technique8. AHD was calculated as the minimum distance between the acromion and the humerus at 10° increments of GH abduction and averaged throughout the motion. Humeral head translation, defined as the relative translation of the center of the humeral head compared to the center of the glenoid, was calculated at 10° increments of GH abduction and expressed as averages in the superior/inferior (SI) and anterior/posterior (AP) directions. Differences between PRE and 1YR-POST static AHD, average dynamic humeral head location, PROs, and maximum GH abduction were evaluated using a paired t-test. A Pearson correlation was used to determine associations between static AHD and average humeral head location, and both PROs and maximum GH abduction. Significance was set at p < 0.05 for all tests. Results: There was no difference in static AHD from PRE (5.3±1.6mm) to 1YR-POST (4.6±1.6mm) while the average dynamic AHD during GH abduction decreased from 2.7±1.2mm PRE to 2.3±1.0mm 1YR-POST (Figure 1). Static AHD was larger than the average dynamic AHD both PRE and 1YR-POST (Figure 1). The average position of the humeral head during abduction moved 1.5% of the glenoid height superior from PRE to 1YR-POST and 1.7% of the glenoid width anterior from PRE to 1YR-POST (Figure 2). ASES, WORC, and DASH scores significantly improved from PRE to 1YR-POST and maximum GH abduction significantly increased from PRE (78.1±23.1°) to 1YR-POST (93.9±12.3°) (Table 1). Interestingly, there was a positive correlation between the AP humeral head location and DASH score PRE such that a higher DASH score was associated with the humeral head being more anterior (R = 0.767). No other associations were found between either average humeral head locations or AHD and either PROs or maximum GH abduction at both time points as well as the changes in those measures between time points (all R < 0.67). Conclusions: Static AHD, as measured clinically, may not be a good representation of dynamic AHD during scapular abduction given the differences between the static and dynamic AHD measurements at similar abduction angles. Additionally, our in vivo kinematics findings are not consistent with prior results of a cadaver-based biomechanical study of SCR as we found were minute changes in the SI humeral head position, with a 0.4mm more superior humeral head position following SCR. Regardless, patient-reported qualitative outcomes and maximum GH abduction all improved significantly. This suggests clinical outcomes after SCR may be influenced by mechanisms other than restoration of humeral head translation. Future in vivo studies are needed to evaluate the kinematic mechanisms behind improved PROs after SCR. [Table: see text]
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LeVasseur, Clarissa, Alexandra Gabrielli, Adam Popchak, James Irrgang, William Anderst, Albert Lin, and Gillian Kane. "Changes in In Vivo Glenohumeral Joint Contact Patterns After Arthroscopic Superior Capsule Reconstruction." Orthopaedic Journal of Sports Medicine 8, no. 7_suppl6 (July 1, 2020): 2325967120S0041. http://dx.doi.org/10.1177/2325967120s00415.
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Objectives: Patients with irreparable rotator cuff tears (RCT) exhibit functional limitations believed to be caused by superior migration of the humerus1,2. One viable treatment is superior capsule reconstruction (SCR). SCR has been shown to restore stability of the glenohumeral (GH) joint in cadavers1, but its effectiveness at controlling in vivo humeral motion is unknown. Outcomes are typically evaluated through standard clinical radiographs to assess acromial-humeral distance (AHD), and patient-reported outcomes (PROs) such as ASES and Visual Analog Scale3. Reported changes in AHD are inconsistent, with some studies reporting an increase in AHD of 2.6 to 3.2 mm4,7, while other studies reported no significant change5,6 in AHD after SCR. Scapulohumeral rhythm (SHR), a measure of shoulder motion fluidity, has been reported at 2:1 (glenohumeral to scapulothoracic motion) in healthy individuals9, but the effects of SCR on SHR are unknown. The aim of this study was to determine the effect of SCR on static and dynamic AHD, shoulder function, and patient-reported outcomes. We hypothesized that after SCR, static and dynamic AHD would increase, SHR would approximate that of a healthy shoulder, maximum GH abduction would increase, and PROs would improve. Methods: Ten patients with irreparable RCT provided informed consent prior to receiving human dermal allograft SCR. To date, seven (6M, 1F, age 60 ± 8 years) have returned for 1 year post-operative testing. ASES, DASH, and WORC surveys were completed before (PRE), 6 months (6MO-POST), and 1-year after SCR (1YR-POST). Synchronized biplane radiographs of the shoulder were collected PRE and 1YR-POST at 50 images/s while patients performed 3 trials of scapular plane arm abduction. Six degree of freedom GH and scapular kinematics were determined with sub-millimeter accuracy by matching subject-specific CT-based bone models of the humerus and scapula to radiographs using a validated volumetric tracking technique8. AHD was calculated as the minimum distance between the acromion and the humerus at 5° increments of GH abduction. Scapulohumeral rhythm (SHR) was calculated by finding the average change in glenohumeral abduction per degree of scapular upward rotation during scapular abduction.Differences between PRE and 1YR-POST SHR and static AHD distance were evaluated using a paired t-test with significance set at p < 0.05. Changes in PROs were compared to the minimum clinically important difference (MCID). Results: There was a trend toward decreasing static AHD from PRE to 1YR-POST (average decrease: 1.5±1.6mm (p=0.06), however, dynamic AHD did not change from PRE to 1 YR-POST between 45° and 95° of glenohumeral abduction (all p > 0.11) (Figure 1). There was a trend toward increased SHR from 1.1 ± 0.5 PRE to 1.5 ± 0.3 1YR-POST (p = 0.08) (Figure 2), while the increase in maximum GH abduction during scapular abduction from PRE (76.7°±24.5°) to 1YR-POST (91.8°±14.9°) was not statistically significant (p = 0.14) (Figure 2). ASES, WORC, and DASH scores improved beyond the minimum clinically important difference from PRE to 1YR-POST (Table 1) for all patients. Conclusion: In general, SHR tended to more closely resemble that of a healthy shoulder following SCR. Althoughaverage maximum GH abduction was higher postoperatively than preoperatively, that increase was not statistically significant and may reflect that most patients in our cohort had reasonable preoperative abduction. In contrast to those quantitative measures of shoulder function, patient-reported qualitative outcomes all improved significantly. Conflicting results between static and dynamic AHD during higher glenohumeral abduction angles suggest SCR does not appear to affect AHD in higher abduction angles, though the static AHD suggests there may be a difference at lower abduction angles. Dynamic measurements of AHD at lower abduction angles will be necessary to fully characterize the dynamic changes of AHD following SCR. [Figure: see text]
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Melin, Eva Olga, Magnus Hillman, and Mona Landin-Olsson. "Midnight salivary cortisol secretion associated with high systolic blood pressure in type 1 diabetes." Endocrine Connections 8, no. 11 (November 2019): 1520–28. http://dx.doi.org/10.1530/ec-19-0407.
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Objective To explore associations between high midnight salivary cortisol (MSC) secretion and high blood pressure (BP) in type 1 diabetes (T1D). Methods Cross-sectional study of 196 adult patients with T1D (54% men). Associations between high MSC (≥9.3 nmol/L) and high systolic BP (>130 mmHg), and high diastolic BP (>80 mmHg) were explored for all patients, users and non-users of antihypertensive drugs (AHD). Adjustments were performed for age, sex, diabetes-related variables, p-creatinine, smoking, physical inactivity, depression and medication. Results The prevalence of high MSC differed between patients with high and low systolic BP in all 196 patients: 39 vs 13% (P = 0.001); in 60 users of AHD: 37 vs 12% (P = 0.039), and in 136 non-users of AHD: 43 vs 13% (P = 0.012). Significant associations with high systolic BP were for all patients: physical inactivity (adjusted odds ratio (AOR) 6.5), high MSC (AOR 3.9), abdominal obesity (AOR 3.7), AHD (AOR 2.9), age (per year) (AOR 1.07), and p-creatinine (per µmol/L) (AOR 1.03); for 60 users of AHD: high MSC (AOR 4.1) and age (per year) (AOR 1.11); for 136 non-users of AHD: abdominal obesity (AOR 27.4), physical inactivity (AOR 14.7), male sex (AOR 9.0), smoking (AOR 7.9), and age (per year) (AOR 1.08). High MSC was not associated with high DBP. Conclusions In adult patients with T1D, high systolic BP was associated with physical inactivity, high MSC secretion, abdominal obesity, p-creatinine, age, and AHD, the latter indicating treatment failure.
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Martín-San Agustín, Rodrigo, Alba Cuerda-Del Pino, Noemi Moreno-Segura, Adrian Escriche-Escuder, and Mariana Sánchez-Barbadora. "Influence of rigid taping on the acromiohumeral distance in healthy recreational weightlifters." PeerJ 9 (August 26, 2021): e12093. http://dx.doi.org/10.7717/peerj.12093.
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Background Subacromial pain syndrome is one of the most frequent injuries in overhead athletes, and it takes place when the acromiohumeral distance (AHD) is narrowed. Conservative treatment is the first approach to this syndrome, being shoulder taping one of the most used techniques. Although there are quite a few studies that analyse the effect of taping on the AHD, most of them do not include sham tapings. This study aimed to examine if the Relocation of the humeral head (RHH) taping produced an increase in the AHD in healthy recreationally weightlifter males, quantifying the change that may be due to a placebo effect. Methods The design of this study was a two-group pretest-posttest, in which eighteen healthy recreationally weightlifter males were measured. in a laboratory of the University of Valencia. RHH using rigid or sham taping was randomly applied to the participants. The AHD was measured and registered before and after the application of the taping for both groups by a blinded examiner using ultrasound. Results There were no significant differences between pre and post measures in the sham group (p = 0.51). The experimental group showed a significant AHD increase of 9.2% (10.75 ± 1.89 vs 11.74 ± 1.82, respectively, with p < 0.001). Significant differences in the effects of each taping on the AHD were found between groups (p < 0.001). The results of this study indicate that the RHH rigid taping increases the AHD in the shoulders of recreationally weightlifters, dismissing the possibility of a placebo effect of the taping.
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Agarwal, Neha, and Sunil Taneja. "Acquired heart disease in children is not necessarily rheumatic." Tropical Doctor 49, no. 3 (March 13, 2019): 181–84. http://dx.doi.org/10.1177/0049475519833513.
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Acquired heart diseases (AHD) cause significant morbidity and mortality in children. There are limited studies on their burden in children. We conducted a retrospective study of 85 consecutive children diagnosed with AHD using clinical evaluation and echocardiography at Medical College, Kanpur, India to determine the aetiology and outcome of AHD in children. We found rheumatic heart disease (RHD) in one-third, cardiomyopathies or myocarditis combined in a further third and the remaining third were other causes, including pericardial diseases and metabolic or genetic disorders. These latter diseases were frequently misdiagnosed, causing significant morbidity and mortality. Hence, in children of all age groups presenting with unexplained shock, dyspnoea, hepatomegaly and ascites, cardiac status should be carefully and critically evaluated so that non-rheumatic AHD may not be missed.
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Rosinski, Steven Lawrence, Farhad Ravandi, Stefan Faderl, Guillermo Garcia-Manero, Sherry Pierce, Hagop M. Kantarjian, and Elihu H. Estey. "Count Recovery in AML Patients Achieving a Complete Response." Blood 114, no. 22 (November 20, 2009): 2062. http://dx.doi.org/10.1182/blood.v114.22.2062.2062.
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Abstract Abstract 2062 Poster Board II-39 AML is typically defined as “de novo” or “secondary”, the latter referring to patients diagnosed only after persistent blood count abnormalities (AHD) or after prior “chemotherapy” (PCT) for other illnesses. Patients with secondary AML may have a different bone marrow microenvironment leading to prolonged neutrophil and platelet recovery times following induction chemotherapy. Accordingly, we compared time from start of chemotherapy to neutrophil recovery (>1,000/μl) and platelet recovery (>100,000/μl) in 424 patients who achieved a complete response (CR) following treatment with ara-C-containing induction therapy at MD Anderson Hospital from 1995 to 2008. We divided the 424 patients as follows: (1) no AHD, no PCT (236 patients); (2) AHD, no PCT (131 patients); (3) PCT, no AHD (28 patients); and (4) AHD and PCT (29 patients). Because time to recovery may also be influenced by cytogenetics and age we subdivided patients in each of the four groups according to age (< vs. ≥ 60) and cytogenetics (normal vs. complex or -5/-7). Despite very differing CR rates, time to neutrophil recovery in patients achieving CR while statistically longer in PCT patients (p=0.05) was from a medical standpoint essentially uninfluenced by AHD and PCT status (table, median delays 2 days with PCT). Platelet recovery was affected by such status (p<0.001) being delayed by a median of 6-8 days in patients who had received PCT. Age had no effect on time to neutrophil (p=0.42) or platelet (p=0.23) recovery, while complex or -5/-7 cytogenetics had a statistically significant (p=0.002 neutrophils, 0.009 platelets) but medically insignificant (median delays of 2 days) effect on recovery time. There was no interaction between age or cytogenetics and AHD or PCT status. A similar analysis in patients who do not achieve CR would be of interest, but might be confounded by the difficulty in distinguishing between the effects of chemotherapy and those of residual AML on count recovery. Our data suggest that older patients, patients with complex or -5/-7 cytogenetics, and patients with secondary AML should not be excluded from clinical trials because of concern about prolonged time to count recovery. Group CRs CR Rate Median Days to > 1000 Neut Median Days to > 100,000 Plt No AHD no PCT 236 68% 27 28 AHD no PCT 131 50% 27 30 PCT no AHD 28 44% 29 34 AHD + PCT 29 35% 30 36 Age < 60 255 64% 28 29 Age ≥ 60 169 48% 26 30 Normal cyto 281 69% 27 29 Complex cyto or -5/-7 143 41% 29 31 Disclosures: No relevant conflicts of interest to declare.
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Bai, Francesca, Camilla Tincati, Esther Merlini, Carlotta Pacioni, Elisabetta Sinigaglia, Giovanni Carpani, Antonella d’Arminio Monforte, and Giulia Marchetti. "Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection." AIDS Research and Treatment 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/314849.
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Objectives. We investigated immune phenotypes of HIV+ patients who present late, considering late presenters (LPs, CD4+ < 350/μL and/or AIDS), advanced HIV disease (AHD, CD4+ < 200/μL and/or AIDS), and AIDS presenters (AIDS-defining condition at presentation, independently from CD4+).Methods. Patients newly diagnosed with HIV at our clinic between 2007–2011 were enrolled. Mann-Whitney/Chi-squared tests and logistic regression were used for statistics.Results. 275 patients were newly diagnosed with HIV between January/2007–March/2011. 130 (47%) were LPs, 79 (29%) showed AHD, and 49 (18%) were AIDS presenters. LP, AHD, and AIDS presenters were older and more frequently heterosexuals. Higher CD8+%, lower CD127+CD4+%, higher CD95+CD8+%, CD38+CD8+%, and CD45R0+CD38+CD8+% characterized LP/AHD/AIDS presentation. In multivariate analysis, older age, heterosexuality, higher CD8+%, and lower CD127+CD4+% were confirmed associated with LP/AHD. Lower CD4+ and higher CD38+CD8+% resulted independently associated with AIDS presentation.Conclusions. CD127 downregulation and immune activation characterize HIV+ patients presenting late and would be studied as additional markers of late presentation.
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Bdaiwi, Alya H., Tanya Anne Mackenzie, Lee Herrington, Ian Horlsey, and Ann Cools. "The Effects of Rigid Scapular Taping on Acromiohumeral Distance in Healthy Shoulders: An Observational Study." Journal of Sport Rehabilitation 26, no. 1 (January 2017): 51–56. http://dx.doi.org/10.1123/jsr.2015-0086.
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Context:Compromise to the acromiohumeral distance (AHD) has been reported in subjects with subacromial impingement syndrome when compared with healthy subjects. In clinical practice, patients are taped with the intention of altering scapular position and influencing the AHD. However, research to determine the effects of taping on AHD is exiguous.Objectives:To evaluate the effect of ridged taping techniques to increase posterior scapular tilt and upward scapular rotation on the AHD.Design:1-group pretest/posttest repeated-measures design.Setting:Human performance laboratory.Participants:20 asymptomatic participants (10 male and 10 female) age 27 y (SD 8.0 y).Intervention:Ridged tapping of the scapula into posterior tilt and upward scapular rotation.Main Outcome Measure:Ultrasound measurement of the AHD.Results:AHD increased significantly after rigid tape application to the scapula (P < .003) in healthy shoulders in 60° of passive arm abduction.Conclusion:Taping techniques applied to the scapula had an immediate effect of increasing the AHD in healthy shoulders in 60° of passive arm abduction. Results suggest that taping for increasing posterior scapular tilt and increasing scapular upward rotation can influence the AHD and is a useful adjunct to rehabilitation in patients with subacromial impingement syndrome.
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Smithson, Elliot V., Elizabeth Reed Smith, Gary McIlvain, and Mark K. Timmons. "Effect of Arm Position on Width of the Subacromial Space of Upper String Musicians." Medical Problems of Performing Artists 32, no. 3 (September 1, 2017): 159–64. http://dx.doi.org/10.21091/mppa.2017.3026.
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OBJECTIVE: Musicians often end their musical career due to musculoskeletal injury. A leading source of shoulder pain in upper string musicians is rotator cuff disease (RCD). Multiple factors contribute to its development. Compressive overload of the soft tissues of the subacromial space resulting from a decrease in the width of the subacromial space has been identified as an extrinsic factor contributing to RCD development. The purpose of this study was to characterize the width of the subacromial space by measuring acromial-humeral distance (AHD) of upper string musicians, while their arms are in standard playing positions. METHODS: Experienced musicians (n=23) were recruited from local communities. Shoulder ultrasound images were collected using standard imaging techniques. Images were collected and the AHD measured while the musician’s arm was in positions associated with playing the violin. RESULTS: On the right side, the arm position main effect was significant (p<0.001): the AHD in the 4th string position (8.8±1.9 mm) was less than the 1st string (11.3±1.4 mm) and resting (11.7±1.3 mm) positions. There was no difference in AHD between resting (10.0±5.8 mm) and instrument-support positions (10.6±1.5 mm). The resting AHD was smaller (p=0.04) on the right side compared to the left (12.2±1.4 mm). There was not statistically significant difference (p=0.138) in the occupation ratio (supraspinatus tendon thickness/AHD) between the right (mean 0.543±0.80 mm) and left sides (mean 0.510±0.087 mm). CONCLUSIONS: The AHD measurement decreased in the playing positions compared to resting positions. Treatment interventions that help musicians maximize the width of their subacromial space might help reduce the prevalence of shoulder pain in this population.
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Lee, Seung-Jun, Young-Kyoung Min, Il-Kwon Chung, Suk-Woong Kang, and Scott A. Banks. "Comparison of Dynamic In Vivo Shoulder Kinematics Before and After Superior Capsular Reconstruction for Irreparable Rotator Cuff Tears." Orthopaedic Journal of Sports Medicine 9, no. 1 (January 1, 2021): 232596712097050. http://dx.doi.org/10.1177/2325967120970502.
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Background: Superior capsular reconstruction (SCR) is an alternative surgical option for young active patients with irreparable rotator cuff tears without arthritis. Although cadaveric studies have shown superior stability of the humerus, it remains unclear whether the humerus migrates superiorly after SCR in vivo. Purpose: To analyze the change in glenohumeral translation in patients before and after SCR. Study Design: Case series; Level of evidence, 4. Methods: A total of 22 patients who underwent SCR by a single surgeon for irreparable rotator cuff tears were included. Among them, 14 patients had intact grafts, and 8 patients were diagnosed with retears on 1-year postoperative magnetic resonance imaging (MRI) scans. Fluoroscopy was performed in all patients preoperatively and at 3-month, 6-month, and 1-year follow-up. Moreover, 3-dimensional bone models from computed tomography, MRI, and fluoroscopic scans during scapular plane abduction of the shoulder joints were analyzed. Results: In the intact graft group, 3-dimensional dynamic shoulder kinematics at 6 months ( P = .026) and 1 year ( P = .032) postoperatively showed statistically significant decreases in humeral head superior translation compared with preoperatively. The ≥6-mm acromiohumeral distance (AHD) subgroup had a larger decrease in humeral head superior translation from preoperatively than did the <6-mm AHD subgroup (6 months: P = .026; 1 year: P = .032). The retear group had significantly greater humeral head superior translation at 1 year postoperatively than did the ≥6-mm and <6-mm AHD subgroups (post hoc test: P < .001; ≥6-mm AHD vs retear group: P = .001; <6-mm AHD vs retear group: P = .012). Conclusion: SCR with intact grafts resulted in decreased humeral head superior translation after 6 months. Patients with retears showed no improvement in humeral head superior translation. Patients with a preoperative AHD <6 mm had less improvement in humeral head superior translation than did those with a preoperative AHD ≥6 mm. Early surgical treatment before an excessive decrease in preoperative AHD could be helpful for postoperative humeral head translation recovery.
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Kholinne, Erica, Jae-Man Kwak, Yucheng Sun, Hyojune Kim, Dongjun Park, Kyoung Hwan Koh, and In-Ho Jeon. "The relationship between rotator cuff integrity and acromiohumeral distance following open and arthroscopic rotator cuff repair." SICOT-J 7 (2021): 23. http://dx.doi.org/10.1051/sicotj/2021012.
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Background: Acromiohumeral distance (AHD) has become both a diagnostic and prognostic parameter related to rotator cuff pathology which is always measured in a 2-dimensional plane. The purposes of this study were (1) to evaluate the regional AHD with MRI following open and arthroscopic rotator cuff repair and, (2) to investigate its association to the rotator cuff integrity following medium to large size rotator cuff repair with open and arthroscopic manner. Methods: A retrospective review of 112 patients who were treated for full-thickness medium to large size rotator cuff tears either by open repair (open group) or arthroscopic repair (arthroscopic group) was done. All patients included in the study are those with at least 12 and 18 months for the post-operative MRI and clinical follow-up. Propensity score matching was used to select controls matched for age, sex, body mass index, tear size, and affected site. There were 56 patients in each group with a mean age of 63.3 years (range, 50 to 77 years). The post-operative functional and radiologic outcomes for both groups were compared. AHD was measured at three regions of interest (ROI) with MRI and compared pre-and post-operatively. Results: AHD was significantly greater in the open group when measured at the anterior third of the lateral acromion border compare to the arthroscopic group (p = 0.005). The re-tear rate was affected by AHD at the anterior third of the lateral border of the acromion for the arthroscopic and open group (p = 0.021, p = 0.029). The AHD measured at the anterior and middle third of lateral acromion border were significantly greater in healed compared to the re-tear rotator cuff group (p = 0.019, p = 0.022). Conclusions: Open rotator cuff repair showed greater AHD at the anterior third of the lateral border of the acromion. Regional AHD measured at anterior third of the lateral border of acromion significantly associated with rotator cuff integrity following repair. Level of evidence: propensity-matched case-control (Level II)
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Leonova, M. V., Yu B. Belousov, L. L. Shteinberg, E. E. Alimova, E. P. Smirnova, and D. Yu Belousov. "The results of the pharmacoepidemiological study PIFAGOR IV concerning arterial hypertension (AH patients survey)." Systemic Hypertension 12, no. 3 (September 15, 2015): 11–18. http://dx.doi.org/10.26442/sg29091.
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Group of researchers analytical group of PIFAGOR IV study The aim is to study the next step of pharmacoepidemiology of arterial hypertension (AH) in Russia to evaluate the structure and frequency of different classes of antihypertensive drugs (AHD) usage in clinical practice.Material and methods. The prospective pharmacoepidemiological multicenter study (PIFAGOR IV). We interrogated AH patients using special prepared questionnaires. The collection of questionnaires took place from February to July, 2013. The study included 2533 valid questionnaires from 52 cities and towns of Russia.Results. 80% of the patients regularly take AHD; 32.8% of patients receive monotherapy, 38.6% receive two AHD combinations, 28.4% - 3 or more AHD combinations. The average number of AHD was 2.02 per patient. The structure of AHD consisted of 5 recommended classes: ACE inhibitors (27.8%), -adrenergic receptor blocking agents (21.7%), diuretics (15.7%), calcium antagonists (11.3%) and angiotensin II receptor blockers (10.7%), fixed combination - 10.8%. Additional proportion of classes: central-acting agents - 2.3% and b-adrenoceptor blocking agents - 0.1%. Among the ACE inhibitors the main share had 3 drugs: enalapril (33.6%), perindopril (16%), and lisinopril (13%). In b-blockers class the main share had 2 drugs - bisoprolol (64.4%), and usual form of release and modified release dosage form of metoprolol (the total share 21,4%). Indapamide of standard and retard form took the first place in the structure of diuretics (the total share 75%). In calcium antagonists class the main share had amlodipine (55.8%). The main drug in ARBs II was losartan (55.4%). Central-acting agent class was consisted of moxonidine (66%), methyldopa (17%) and clonidine (5%). For about 76% of cases were presented by combinations containing diuretics and 24% - by combinations containing calcium antagonists among the fixed combinations. The proportion of original drugs in the structure of AHD was 38.3%. The average BP level in patients was 140.4/86.4 mm Hg and the blood pressure targets were determined in 50.2% of cases. A high degree of compliance according to the Morisky-Green test indicated in 32%, low compliance - in 49% of cases.Conclusions. We noted the reduction of ACE inhibitors proportion and increase of ARBs II proportion, increase of fixed combinations in the structure of AHD. However, we noticed the decrease of the treatment efficacy in patients with AH using average BP level and achievement of the target BP, as well as the average number of AHD.
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Tixier, Paul, Nicolas Gasco, Guy Duhamel, and Christophe Guinet. "Habituation to an acoustic harassment device (AHD) by killer whales depredating demersal longlines." ICES Journal of Marine Science 72, no. 5 (October 7, 2014): 1673–81. http://dx.doi.org/10.1093/icesjms/fsu166.
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Abstract Acoustic harassment devices (AHDs) have been increasingly implemented in various fisheries that suffer significant losses caused by odontocete depredation. However, the efficacy of AHDs to deter odontocetes from fishing gear remains poorly investigated. To determine the effectiveness of AHDs in deterring depredation, we experimentally tested a high amplitude device (195 dB re 1 μPa 6.5 kHz 1 m from the source) from a Patagonian toothfish Dissostichus elegenoides longliner operating off the Crozet Islands, while it was subjected to heavy depredation by killer whales Orcinus orca. This species usually depredates longlines within a 10- to 300-m range from the vessel, as they only have access to fishing gear during hauling. We expected this distance to increase in response to the acoustic disturbance created by the AHD. The distances of 29 killer whales from the vessel (n = 1812 records) were collected during phases of AHD activation and phases during which the AHD was turned off. Two multiexposed killer whale social units fled over 700 m away from the vessel when first exposed to the AHD. However, they remained within a 10- to 300-m range and depredated longlines again past the third and seventh exposures, respectively, showing an insignificant behavioural response to further activations of the AHD. When tested through generalized linear mixed models, the effect of AHD activation was only significant when killer whales were first exposed to the device. However, the effect disappeared after successive exposures suggesting that killer whales became habituated to the AHD and may sustain potentially harmful hearing disturbance to access the resource made available by longliners. In addition to raising significant conservation concerns, this rapid return of initial depredation behaviour strongly suggests that AHDs are ineffective at deterring depredating killer whales, and that fisheries should favour the use of other mitigation techniques when facing repeated depredation by this species.
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Ha, Duc, Michael Faulx, Carlos Isada, Michael Kattan, Changhong Yu, Jeff Olender, Craig Nielsen, and Andrei Brateanu. "Transitioning From a Noon Conference to an Academic Half-Day Curriculum Model: Effect on Medical Knowledge Acquisition and Learning Satisfaction." Journal of Graduate Medical Education 6, no. 1 (March 1, 2014): 93–99. http://dx.doi.org/10.4300/jgme-d-13-00185.1.
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Abstract Background The academic half-day (AHD) curriculum is an alternative to the traditional noon conference in graduate medical education, yet little is known regarding its effect on knowledge acquisition and resident satisfaction. Objective We investigated the association between the 2 approaches for delivering the curriculum and knowledge acquisition, as reflected by the Internal Medicine In-Training Examination (IM-ITE) scores and assessed resident learning satisfaction under both curricula. Methods The Cleveland Clinic Internal Medicine Residency Program transitioned from the noon conference to the AHD curriculum in 2011. Covariates for residents enrolled from 2004 to 2011 were age; sex; type of medical degree; United States Medical Licensing Examination Step 1, 2 Clinical Knowledge; and IM-ITE-1 scores. We performed univariable and multivariable linear regressions to investigate the association between covariates and IM-ITE-2 and IM-ITE-3 scores. Residents also were surveyed about their learning satisfaction in both curricula. Results Of 364 residents, 112 (31%) and 252 (69%) were exposed to the AHD and the noon conference curriculum, respectively. In multivariable analyses, the AHD curriculum was associated with higher IM-ITE-3 (regression coefficient, 4.8; 95% confidence interval 2.9–6.6) scores, and residents in the AHD curriculum had greater learning satisfaction compared with the noon conference cohort (Likert, 3.4 versus 3.0; P = .003). Conclusions The AHD curriculum was associated with improvement in resident medical knowledge acquisition and increased learner satisfaction.
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Benitez-Martinez, Josep C., Jose Casaña-Granell, Yasmin Ezzatvar de Llago, Carlos Villaron-Casales, Gemma V. Espi-Lopez, and Fernando Jimenez-Diaz. "Cross Sectional Area of the Supraspinatus Muscle and Acromio-humeral Distance in Overhead Athletes With and Without Shoulder Pain: A Cross-sectional Study." Journal of Sport Rehabilitation 26, no. 6 (November 2017): 524–29. http://dx.doi.org/10.1123/jsr.2016-0146.
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Context:The supraspinatus muscle has an important role in the stabilization of the glenohumeral joint. Identifying abnormalities concerning its size and the subacromial space in the presence of pain may be relevant to provide more specific treatments focused on the etiology of pain.Objective:To determinate whether painful shoulder causes changes in the supraspinatus cross-sectional area (CSA) and the acromio-humeral distance (AHD) between overhead athletes.Design:Cross-sectional study.Setting:University campus and local sports clubs’ Physical Therapist room.Participants:81 male overhead athletes were divided into 2 groups according to the presence of shoulder pain and clinical symptoms.Main Outcome Measures:Ultrasonography measurements of the supraspinatus CSA and the AHD in 2 groups of overhead athletes with and without pain.Results:In the pain group, the CSA was significantly smaller compared with the no pain group. No differences between groups were found in the AHD measurement.Conclusions:Shoulder pain in overhead athletes was associated with a reduction in their supraspinatus muscle CSA, but not in the AHD. These findings suggest that muscle atrophy exists in the presence of pain. However, in active overhead athletes, the AHD is not clearly reduced in overhead athletes with shoulder pain. Further studies are needed to understand this condition.
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Nilsson, Christer, Erik Hulegårdh, Vladimir Lazarevic, Hege Garelius, Asa Rangert Derolf, Lars Möllgård, Lovisa Wennström, et al. "Allogeneic Transplantation in First Remission Improves Outcome in Secondary Acute Myeloid Leukemia." Blood 124, no. 21 (December 6, 2014): 281. http://dx.doi.org/10.1182/blood.v124.21.281.281.
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Abstract Allogeneic stem cell transplantation (SCT) is widely used as post-remission treatment in younger patients with poor or intermediate risk AML. Transplant decisions are mainly based on cytogenetic and molecular risk group, age, comorbidity and on the availability of a suitable donor. Secondary AML, including therapy-related AML (t-AML) and AML after an antecedent hematological disorder (AHD-AML), constitutes more than one fourth of the AML cases and is a predictor of a poor outcome. However, the extent to which SCT improves outcome of this patient group is poorly studied. In this study, we set out to investigate the role of SCT for the survival of secondary AML patients within the population-based Swedish Adult Acute Leukemia Registry. In total, 5881 patients with AML diagnosed during the period 1997 – 2013 were included in the study. Of these, 4233 (72%) were de novo AML, 1098 (19%) AHD-AML and 550 (9%) t-AML. The median age at diagnosis was 70 in de novo AML, 73 in AHD-AML and 70 in t-AML. The gender distribution was equal in de novo AML (51% males). In AHD-AML, there was a male predominance of 57% whereas in t-AML, there was a female predominance of 56%. The proportion of patients who underwent SCT in first remission (CR1) was 10% in de novo AML, 5% in AHD-AML and 8% in t-AML (de novo vs AHD-AML p < 0.001, de novo vs t-AML p = 0.068, AHD-AML vs t-AML p = 0.081; Fisher's exact test). In patients aged 65 or below, the proportion of SCT in CR1 was 24%, 21% and 20%, respectively. The median age of SCT patients was 48 (range 17 – 71) in de novo AML, 57 (27 – 76) in AHD-AML and 49.5 (18 – 68) in t-AML. In de novo AML, the distribution of genetic risk groups among SCT patients was 3% low risk, 55% intermediate risk and 42% high risk. Corresponding figures for AHD-AML was 0%, 34% and 66% and for t-AML 5%, 45% and 50% respectively (de novo vs AHD-AML p = 0.004, de novo vs t-AML p = 0.299, AHD-AML vs t-AML p = 0.124; Fisher's exact test). The estimated median survival after the date of SCT in CR1 was 15 months in AHD-AML and 22 months in t-AML but not reached in de novo AML (95% lower confidence limit 107 months). Among patients <65 years who had been in CR for 3 months (genetic low risk excluded), those with secondary AML had a greater benefit from consolidation with SCT than those with de novo AML (Figure 1). The projected 7-year survival in de novo AML was 60% with SCT and 44% with conventional post remission therapy (CPRT) as compared to 46% and 21%, respectively, in secondary AML. The survival hazard with SCT was 0.45 in secondary AML (95% CI 0.28-0.72) as compared to 0.66 in de novo AML (CI 0.53 – 0.82), by multivariable Cox regression adjusting for type of secondary AML, age, sex, and cytogenetic risk group. To refine the analysis correcting for major confounding factors, a matched pair analysis was performed in patients with CR longer than 3 months. Matching criteria were type of secondary AML (AHD or t-AML), cytogenetic risk group and age (+/- 3 years). Remission of the patient with CPRT was at least as long as the time between CR1 and transplantation for the matched patient undergoing SCT. The projected 7-year survival rate was 43% in the SCT and 8% in the CPRT group (p = 0.01; log-rank test, Figure 2) further indicating a benefit for SCT as post remission therapy in secondary AML. We conclude that SCT improves survival in patients with secondary AML. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.
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Su, Xiaoyan, Changqing Song, and Gary Sigley. "The Uses of Reconstructing Heritage in China: Tourism, Heritage Authorization, and Spatial Transformation of the Shaolin Temple." Sustainability 11, no. 2 (January 15, 2019): 411. http://dx.doi.org/10.3390/su11020411.
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Recently, debates on authenticity in the West and China have attracted attention of critical heritage studies. This paper aims to better understand how Western Authorized Heritage Discourse (AHD) influences local heritage practice in China. This paper employs observation, semi-structured interviews and textual analysis to examine how authenticity criteria in Western AHD has shaped perceptions on the spatial consequences of what is “authentic” by different agents in regards to the cultural heritage of the Shaolin Temple. It is argued that the implementation of authenticity criteria found in Western AHD influences Shaolin heritage practice both in hegemonic and negotiated ways, in which a Chinese AHD is formed through the creation of a Western AHD with Chinese characteristics. The understandings on authenticity criteria derived from Western AHD by Chinese heritage experts dominates Shaolin heritage practice, whilst the perceptions on “authentic” Shaolin Temple cultural heritage attached closely to their emotions and experiences by local residents are neglected and excluded. The religiously based authenticity claims of the Shaolin monks which competes with those of the heritage experts and local residents are also considered. Furthermore, the managerial structure was changed in 2010 from a government-directed institution to a joint-venture partnership. The impacts of these managerial changes are also considered. The final outcome of these competing heritage claims was that local residents were relocated far from their original community. Without the residential community in situ, and in conjunction with the further commercialization of local culture, the Shaolin Temple heritage site takes on the features of a pseudo-classic theme park.
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Teržan, Karmen. "Das Worden-Passiv als syntaktische Verstärkung im Deutschen." Linguistica 30, no. 1 (December 1, 1990): 69–99. http://dx.doi.org/10.4312/linguistica.30.1.69-99.
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Zur Problematik des althochdeutschen und mittelhochdeutschen Passivs* Auf der frühesten Entwicklungsstufe, welche durch schriftliche Überlieferung belegt werden kann, d.h. in der althochdeutschen Zeit (Ahd.), wurde das Passiv mit Hilfsverben "sein" (ahd. uuesan/wesan) oder "werden", (ahd. uuerdhan/werdan) und dem Partizip II gebildet. Als altere Variante gilt die wesan-Periphrase; das Hilfsverbum werdan aber hat sich etwas spater, jedoch noch in der vorliterarischen Periode, aus dem urspriinglichen Aspektsystem losgelöst, urn sich im System der Genera Verbi zu integrieren, und hat schon im Althochdeutschen als eines der Hilfsverben zur Bildung des Passivs Fuss gefasst. (Nach z. B. OEberg 1907, Valentin 1986).
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Haque, Nadia S. K., Celeste J. Leblanc, and Ole Isacson. "Differential Dissection of the Rat E16 Ventral Mesencephalon and Survival and Reinnervation of the 6-Ohda-Lesioned Striatum by a Subset of Aldehyde Dehydrogenase-Positive th Neurons." Cell Transplantation 6, no. 3 (May 1997): 239–48. http://dx.doi.org/10.1177/096368979700600307.
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The retinoic acid-generating enzyme, aldehyde dehydrogenase (AHD), is expressed in a subpopulation of dopaminergic neurons found in the substantia nigra. Using AHD and tyrosine hydroxylase (TH) as immunohistochemical markers, we determined whether differential dissection of the embryonic (E16) ventral mesencephalon (VM) into its lateral and medial portions contributed equally to the number of TH cells surviving transplantation, if grafted AHD/TH neurons reinnervate the host striatum according to their normal projection patterns, and examined the functional recovery caused by the implanted cells as assessed by amphetamine-induced rotation in a 6-OHDA-lesioned model of Parkinson's disease. The embryonic tissue was transplanted as solid pieces injected via a 20-gauge lumbar puncture needle into the center of the deafferented striatum. Groups received either one complete ventral mesencephalic piece (VM), two medial pieces of ventral mesencephalic tissue (MVM), or two lateral pieces of ventral mesencephalic tissue (LVM). Both VM and MVM groups showed a significant decrease in amphetamine-induced rotation over time and, there was no difference in the degree of reduction observed between the two groups. Histological evaluation of the transplants revealed a much larger total number of surviving TH cells in grafts from the VM and MVM groups compared to the LVM group. Surviving AHD/TH neurons were found in all groups. Whereas TH staining of the transplanted striatum displayed a halo of graft-derived fibers all around the transplant and integration of these fibers into the host neuropil, AHD staining showed a preferential reinnervation of the dorsolateral striatum corresponding to the normal projection pattern of AHD/TH neurons. In summary, selective dissection of the embryonic ventral mesencephalon is possible, functional recovery as assessed by amphetamineinduced rotation in animals transplanted with MVM is similar to that seen in animals grafted with VM, and AHD/TH neurons have a selective reinnervation pattern in the PD transplantation paradigm. These findings may have implications for the grafting of fetal mesencephalic tissue in PD patients.
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Schuhmann, Roland. "Zur Etymologie des Hapaxlegomenons ahd. urrea ‚Turm‘." Neophilologus 100, no. 1 (September 24, 2015): 81–86. http://dx.doi.org/10.1007/s11061-015-9453-5.
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Wagner, Norbert. "Lat.-germ. Chatti und ahd. Hessi ,Hessen." Historical Linguistics 124, no. 1 (July 1, 2011): 277–80. http://dx.doi.org/10.13109/hisp.2011.124.1.277.
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Schuhmann, Roland, and Andreas Nievergelt. "Zur Etymologie von ahd. musina und orgina." Amsterdamer Beiträge zur älteren Germanistik 76, no. 3 (December 1, 2016): 363–70. http://dx.doi.org/10.1163/18756719-12340034.
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In this article, new etymologies for two Old High German words are proposed. Old High German musina ‘bag, satchel’ is explained as a loanword from Slavonic (cf. Old Church Slavonic mošьna ‘bag’), Old High German orgina ‘bit’ as a loanword from Middle Latin *orginum ‘iron ring’. Im Folgenden wird für zwei althochdeutsche Wörter, die bisher etymologisch unklar waren, jeweils eine neue Etymologie vorgeschlagen: Ahd. musina ‚Tasche, Ranzen‘ wird als ein Lehnwort aus dem Slawischen (vgl. aksl. mošьna ‚Tasche‘), ahd. orgina ‚Gebiss, Mundstück am Pferdezaum‘ als Lehnwort aus mlat. *orginum ‚Eisenring‘ erklärt. This article is in German Language.
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Schuhmann, Roland. "Anmerkungen zur Etymologie von ahd. sahar ‚Segge‘." Amsterdamer Beiträge zur älteren Germanistik 79, no. 4 (April 6, 2020): 443–56. http://dx.doi.org/10.1163/18756719-12340166.
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Abstract In the etymological literature there exist two divergent reconstructions for the word group around OHG sahar ‘sedge’: PGmc. *saχaza- and *saχ(a)ra-. Of these two the former is nearly exclusively found in Indo-European literature. The reconstruction *saχaza- cannot be correct. This is obvious because of the forms found in the Romanic languages, that were borrowed from Gothic, a language that did not undergo rhotazism. The neglect of literature from the field of Romance Studies is therefore accountable for the persistence of a false reconstruction in Indo-European studies.
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Šekli, Matej. "Zur Datierung der (bairisch-)alt- und mittelhochdeutschen Lehnwörter im Slowenischen: relative und absolute Chronologie." Linguistica 60, no. 2 (December 30, 2020): 161–78. http://dx.doi.org/10.4312/linguistica.60.2.161-178.
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Aufgrund der relativen und absoluten Chronologie der Lautveränderungen sowohl im bair. Alt- und Mittelhochdeutschen als auch im Urslawischen, Alpenslawischen und Frühslowenischen kann man für die (bair.-)ahd. und (bair.-)mhd. Lehnwörter im (dialektalen und Schrift-)Slowenischen, die die deutschen oder slawischen diagnostischen phonetischen Eigenschaften aufweisen, eine ziemlich präzise relative und absolute Chronologie der Entlehnungszeit festlegen. Für die Bestimmung der präziseren Entlehnungszeit der (bair.-)ahd. Lehnwörter im Slowenischen sind einige (bair.-)ahd. Lautveränderungen um ca. 750, 770 und 1050 wie auch einige späturslawische Lautveränderungen um ca. 800 von großer Bedeutung. Für die Bestimmung des genaueren Zeitpunktes der Entlehnung von (bair.-)mhd. Lehnwörtern im Slowenischen sind einige (bair.-)mhd. Lautveränderungen um ca. 1050, 1100, 1200 und 1250 bedeutsam.
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Rose, P. A., and R. F. Weick. "Evidence for reorganization of the neuroendocrine centres regulating pulsatile LH secretion in rats receiving neonatal monosodium-l-glutamate treatment." Journal of Endocrinology 113, no. 2 (May 1987): 261–69. http://dx.doi.org/10.1677/joe.0.1130261.
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ABSTRACT Previous research has shown that the combination of anterior hypothalamic deafferentation (AHD) and electrolytic lesions of the anterior part of the arcuate nuclei blocks pulsatile LH secretion in ovariectomized rats, but that neither lesion alone was effective. Furthermore, the combination of AHD with arcuate lesions produced by neonatal treatment with monosodium-l-glutamate (MSG) does not block pulsatile LH release. To distinguish between the various possible reasons for this result, AHD and electrolytic lesions of the arcuate nuclei were combined in rats which had been treated neonatally with MSG or saline of equal osmolarity. One week after brain surgery, venous catheters were installed and blood samples taken at 5-min intervals for up to 3 h for assay of plasma LH. Rats treated with MSG and bearing AHD and electrolytic lesions of the arcuate nuclei continued to show pulsatile secretion of LH. Where the electrolytic lesions were posterior and dorsal to the anterior arcuate nuclei, however, LH release was blocked whether AHD was performed or not, but only in rats treated with MSG. None of the lesion combinations blocked pulsatile LH secretion in rats treated with saline. These results suggest that neonatal MSG treatment leads to a reorganization of the hypothalamus such that the role normally played by the arcuate nuclei in the regulation of pulsatile LH secretion is taken over by other hypothalamic structures. J. Endocr. (1987) 113, 261–269
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Alibazi, Razie J., Afsun Nodehi Moghadam, Ann M. Cools, Enayatollah Bakhshi, and Alireza Aziz Ahari. "The Effect of Shoulder Muscle Fatigue on Acromiohumeral Distance and Scapular Dyskinesis in Women With Generalized Joint Hypermobility." Journal of Applied Biomechanics 33, no. 6 (December 1, 2017): 424–30. http://dx.doi.org/10.1123/jab.2016-0056.
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Muscle fatigue is considered to be one cause of shoulder pain, and subjects with generalized joint hypermobility (GJH) are affected more by shoulder pain. The purpose of this study was to examine the effects of muscle fatigue on acromiohumeral distance (AHD) and scapular dyskinesis in women with GJH. Thirty-six asymptomatic participants were assigned to either a GJH (n = 20) or control group (n = 16) using the Beighton scale. Before and after elevation fatigue trials, AHD was measured with ultrasonography at rest and when the arm was in 90° active elevation. A scapular dyskinesis test was used to visually observe alterations in scapular movement. Our results showed that in both groups, the fatigue reduced AHD in the 90° elevation position and increased the presence of scapular dyskinesis; however, no differences were found between the two groups. Although GJH has been identified as a factor for developing musculoskeletal disorders, generalized joint hypermobility did not result in changes to scapular dyskinesis or AHD, even after an elevation fatigue task. More studies are needed to evaluate the effects of muscle fatigue in subjects with GJH and a history of shoulder instability.
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Massaad, Samia O., Mohammed Ahmed A. Ahmed, Afra M. Mustafa, Sami Eldirdiri Elgaili Salah, Saeed M. Omar, Rabie A. Babiker, and Amar Mohammed Mahjoub. "Acquired heart diseases in children in Gadarif pediatrics teaching hospital, Gadarif state, Eastern Sudan." International Journal of Scientific Reports 7, no. 1 (December 22, 2020): 46. http://dx.doi.org/10.18203/issn.2454-2156.intjscirep20205495.
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<p><strong>Background: </strong>Acquired heart diseases (AHD) are heterogeneous diseases including rheumatic heart disease (RHD) and other affecting the heart and blood vessels after birth but usually appear clinically after 5 years of age. AHD considered as major cause of morbidity and mortality. The present study was designed to document the spectrum, the affected age and clinical characteristics of AHDs in children of Gadarif state, eastern Sudan.</p><p><strong>Methods</strong>: This was a descriptive cross section study conducted in Gadarif pediatrics teaching hospital in period from June to Dec 2019.</p><p><strong>Results: </strong>A total of 46 children from Gadarif pediatrics teaching hospital with confirmed AHD were enrolled in this study. The females were 27 (58.7%), with a male-to-female ratio of 1.4:1. The mean age was 10.6±3.9 years (age’s ≤16 years old); the most common affected age group was 10-14 years accounted 18 (39.1) cases. RHD was the commonest AHD found in 38 (82.6%) patients, the commonest valvular lesion was mitral regurgitation 31 (73.9%).</p><p><strong>Conclusions: </strong>RHD was the most common AHD in the children in the present study, there is need to improve the scope of intervention facilities in the Sudan particularly in rural areas to prevent the growing and spread of these diseases.</p>
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Lim, Jun Hyun, Yong Seop Han, Sang Joon Lee, and Ki Yup Nam. "Risk factors for breakthrough vitreous hemorrhage after intravitreal tissue plasminogen activator and gas injection for submacular hemorrhage associated with age related macular degeneration." PLOS ONE 15, no. 12 (December 3, 2020): e0243201. http://dx.doi.org/10.1371/journal.pone.0243201.
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Purpose We investigated risk factors for breakthrough vitreous hemorrhage (VH) after an intravitreal tissue plasminogen activator (tPA) and gas injection in patients with submacular hemorrhage (SMH) associated with age-related macular degeneration (AMD). Methods The medical records of patients diagnosed with SMH associated with AMD who received an intravitreal tPA (50 μg/0.05 mL) and perfluoropropane gas (0.3 mL) injection were reviewed retrospectively. We analyzed the associations of breakthrough VH with age, sex, best-corrected visual acuity, intraocular pressure, AMD subtype, accompanying sub-retinal pigment epithelium (RPE) hemorrhage, history of cataract surgery, history of hypertension and diabetes mellitus, history of drinking and smoking, and history of antiplatelet or anticoagulant medication. We also examined the relationships between various parameters, including the area ratio of the SMH to the optic disc (AHD) and the height of the SMH obtained from optical coherence tomography. Results In total, 52 eyes from 52 patients were enrolled in this study; 16 eyes (30%) showed breakthrough VH. The proportions of patients with a current smoking history were 75.0% in the VH group and 22.2% in the non-VH group (p = 0.010). Other factors did not differ significantly between the two groups. The proportion of cases with accompanying sub-RPE hemorrhage was 50.0% and 58.3% in the VH and non-VH groups, respectively (p = 0.763). The AHD (p = 0.001) and SMH height (p < 0.001) were significantly greater in the VH group. In a receiver operating characteristic curve analysis, the cut-off values of AHD and SMH height were 20.1 and 1208 μm, respectively. According to logistic regression analysis, when the AHD and SMH height were greater than the individual cut-off values, the odds ratio of VH increased by 10.286 fold (95% confidence interval [CI], 2.452–43.148; p = 0.001) and 75.400 fold (95% CI, 7.991–711.441; p < 0.001), respectively, with respect to their respective reference groups (less than the cut-off value). Among the significant factors associated with VH occurrence, including current smoking, AHD, and SMH height, only current smoking and SMH height were found to be significant in multiple regression analysis (p = 0.040, 0.016). Conclusions The incidence of breakthrough VH was significantly higher in those with current smoking status and for SMH with a larger AHD and greater height. The height of the SMH was more predictable of the possibility of VH than AHD.
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Marcevich, M. U. "Calcium antagonists: principals of therapy in the light of evidence based studies data." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 10, no. 1 (February 28, 2004): 43–45. http://dx.doi.org/10.18705/1607-419x-2004-10-1-43-45.
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Calcium antagonists (CA) are the group of drugs the main property of which are the ability to inhibit calcium influx through the so-called slow calcium channels. According to chemical structure, CA are divided into dihydropyridines (nifedipine, amlodipine, felodipine) and nondihydropyridines (verapamil and diltiazem). CA are also divided into first generation agents (conventional tablets) and second generation agents (long acting agents), the last are not only more convenient bat also more safe drugs. The data of large randomised trials confirm that CA have favorable effect on life prognosis during their regular administration to patients with arterial hypertension, this effect of CA is similar to that of other antihypertensive drugs (AHD). However, CA may be superior to other AHD in preventing stroke and inferior to other AHD in preventing myocardial infarction and congestive heart failure.
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Ayuningtyas, Rachma, Riesta Primaharinastiti, and Mochammad Yuwono. "Optimasi dan Validasi Metode KCKT untuk Identifikasi dan Penetapan Kadar Metabolit Nitrofuran dalam Bakso Udang." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 8, no. 2 (August 29, 2021): 117. http://dx.doi.org/10.20473/jfiki.v8i22021.117-124.
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Pendahuluan: Dikarenakan sifat dari Furazolidon, furaltadon, dan nitrofurantoin yang karsinogenik, perlu dilakukan pengawasan terhadap cemaran metabolit nitrofuran dalam produk berbahan dasar udang. Nitrofuran dimetabolisme secara cepat dalam jaringan tubuh hewan. Tujuan: Penelitian ini bertujuan melakukan validasi metode KCKT untuk penetapan kadar metabolit nitrofuran dalam bakso udang. Metode: Metabolit furazolidone, furaltadone dan nitrofurantoin yaitu 3-amino-2-oxazolidinone (AOZ), 3-amino-5-methylmorpholino-2-oxazolidinone (AMOZ), dan 1-aminohydantoin (AHD) diderivatisasi menggunakan 2-nitrobenzaldehida, diekstraksi dalam etil asetat dan dicuci dengan n-heksana, kemudian disuntikkan ke dalam system KCKT dengan detektor UV-PDA. Pemisahan dilakukan dengan kolom C-18 46 x 250 mm, 5 mm. Sebagai fase gerak adalah ammonium asetat 20 mM : asetonitril (70:30), dengan laju alir 0.5 mL/menit, suhu kolom 40oC, dan volume injeksi 100 µL. Hasil: Metode yang digunakan dapat memisahkan semua metabolit dari senyawa pengotor dengan waktu analisis 40 menit, dan menghasilkan linieritas yang baik dalam rentang konsentrasi 51,90 – 103,79 ng/mL (AOZ); 56,63 - 101,39 ng/mL (AMOZ); dan 49,92 - 89,86 ng/mL (AHD). Akurasi metode dipresentasikan sebagai rekoveri dengan hasil sebesar 78,50 - 102,29% untuk AOZ; 77,02 - 99,87% untuk AMOZ; and 85,54 - 99,77% untuk AHD. Presisi metode dinyatakan dalam simpangan baku relatif (relative standard deviation, RSD) dengan hasil masing-masing adalah 6,10 - 19,90%; 3,68 - 17,75%; and 2,75 - 12,58% untuk AOZ, AMOZ, dan AHD. LOD dan LOQ sebesar 3,09 ng/mL dan 10,29 ng/mL (AOZ); 6,84 ng/mL dan 22,82 ng/mL (AMOZ); serta 4,61 ng/mL dan 15,36 ng/mL (AHD). Kesimpulan: Metode uji dapat digunakan untuk skrining awal untuk mendeteksi dan penetapan kadar cemaran metabolit nitrofuran pada bakso udang.
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Stanković, Branislav, Slavča Hristov, Zvonko Zlatanović, Jovan Bojkovski, and Nevena Maksimović. "Sustainibility ahd Efficiency of Dairy Farms Biosecurity Plans." АГРОЗНАЊЕ 16, no. 4 (April 18, 2016): 437. http://dx.doi.org/10.7251/agren1504437s.
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Antao, B. A. A. "AHD languages-a must for time-critical designs." IEEE Circuits and Devices Magazine 12, no. 4 (July 1996): 12–17. http://dx.doi.org/10.1109/101.526875.
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