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Dissertations / Theses on the topic 'AIDS dementia complex - Pathogenesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Cysique, Lucette Adeline Juliette St Vincent's Hospital UNSW. "Aids dementia complex in the era of highly active antiretroviral therapy: a neuropsychological study." Awarded by:University of New South Wales. St. Vincent's Hospital, 2005. http://handle.unsw.edu.au/1959.4/22074.

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The aim of the thesis was to undertake an evaluation of the neuropsychological functioning of non-demented and demented patients with advanced HIV-infection who have been treated with Highly Active Antiretroviral Therapy (HAART) for several years. One hundred and one non-demented HIV-infected individuals and 23 patients with mild or moderate AIDS Dementia Complex (ADC), from the outpatient clinics and Neurology department at St. Vincent's Hospital, Sydney, Australia were randomly selected to participate in a prospective study of the neurological and neuropsychological complications of HIV dise

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2

Owe-Young, Robert School of Medicine UNSW. "Kynurenine pathway metabolism at the blood-brain barrier." Awarded by:University of New South Wales. School of Medicine, 2006. http://handle.unsw.edu.au/1959.4/26183.

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A major product of HIV-infected and cytokine-stimulated monocytic-lineage cells is quinolinic acid (QUIN), a neurotoxic metabolite of the kynurenine pathway (KP) of L-tryptophan (L-Trp) metabolism. Despite the large number of neurotoxins found in HIV patients with AIDS Dementia Complex (ADC), only QUIN correlates with both the presence and severity of ADC. With treatment, cerebrospinal fluid (CSF) QUIN concentrations decrease proportionate to the degree of clinical and neuropsychological improvement. As endothelial cells (EC) of the blood-brain barrier (BBB) are the first brain-associated cell

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3

Di, Stefano Mariantonietta. "Molecular dynamics in HIV-1 infection of the brain /." Stockholm : Karolinska institutet, 1997. http://diss.kib.ki.se/1997/91-85910-65-1.

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4

Lovec, Theobald Rhonda. "A review of pharmacological and psychosocial management of AIDS dementia complex." Honors in the Major Thesis, University of Central Florida, 1999. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/71.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Health and Public Affairs<br>Nursing

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5

Sabri, Farideh. "Astrocytes during HIV infection of the brain : relevance for neuropathogenesis /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4536-5/.

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6

Anderson, Deborah E. (Deborah Elaine) 1967. "HIV-Associated Dementia: Cofactors as Predictors of Severity of Neurocoenitive Deficits." Thesis, University of North Texas, 1996. https://digital.library.unt.edu/ark:/67531/metadc277756/.

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The objective of the present study was to evaluate the relationship between a set of cofactors and severity of cognitive impairment, to determine if there were any factors which significantly predicted more severe neurocognitive deficits in persons with AIDS. Twenty-four male volunteers recruited from community groups and physician referrals participated. Subjects completed several self-report questionnaires eliciting information regarding demographics and risk factor variables, in addition to a comprehensive battery of neuropsychological tests. A severity of cognitive impairment summary score

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7

Bam, Isabel M. S. "'N Ondersoekende kwalitatiewe studie na die siektenarratiewe van individue met VIGS-demensiekompleks." Diss., Pretoria : [s.n.], 2003. http://upetd.up.ac.za/thesis/available/etd-02092005-091416.

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8

Zheve, Georgina Teurai. "Neuroprotective mechanisms of nevirapine and efavirenz in a model of neurodegeneration." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1003285.

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AIDS Dementia Complex (ADC) is a neurodegenerative disorder implicated in HIV-1 infection that is associated with elevated levels of the neurotoxin, quinolinic acid (QA) which causes a cascade of events to occur, leading to the production of reactive oxygen species (ROS), these being ultimately responsible for oxidative neurotoxicity. In clinical studies, Non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP) have been shown to potentially delay the progressive degeneration of neurons, thus reducing the frequency and neurological deficits associated with

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9

Jasmina, Boban. "Multivokselska magnetno-rezonantna spektroskopija mozga kod HIV+ pacijenata." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=101759&source=NDLTD&language=en.

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UVOD: Neurokognitivni poremećaj udružen sa HIVinfekcijom (HIV associated neurocognitive disorder- HAND) javlja se u oko polovine pacijenata sa HIV-om. HAND obuhvata spektar neurolo&scaron;kih poremećaja koji variraju od asimptomatskog neurokognitivnog poremećaja(ANI), preko blagog kognitivnog o&scaron;tećenja, koje se naziva blagi kognitivni poremećaj (MND) do demencije udružene sa HIV-om (HAD). U evaluaciji i dijagnostici ovog poremećaja koriste se razne laboratorijske, kliničke i metode imidžinga, među kojima magnetno-rezonantni imidžing (MRI) zauzima posebno mesto u pogledu dijagnostike str

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10

Fouche, Jean-Paul. "A diffusion tensor imaging study in HIV patients with and without apathy." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5146.

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Thesis (MScMedSc (Biomedical Sciences. Medical Physiology))--University of Stellenbosch, 2010.<br>ENGLISH ABSTRACT: HIV/AIDS is a global epidemic that accounts for a large percentage of the mortality in South Africa every year. Since the implementation of anti-retroviral treatment, HIV positive individuals have been living longer, and the cognitive impairment associated with the disease is becoming increasingly apparent. During the initial systemic infection of HIV, the virus migrates through the blood-brain barrier and inflicts axonal injury by causing upregulation of cytokines and neuro

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11

Araujo, Marília Ladeira de. "Associação entre senescência celular e comprimento dos telômeros em indivíduos infectados pelo HIV-1 com alterações neurocognitivas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-06012017-103130/.

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HIV associado a desordens neurocognitivas (HAND) continua a ser um grave problema atualmente devido à alta prevalência de suas formas mais brandas. Indivíduos HIV+ possuem o comprimento dos telômeros significativamente mais curtos nas células mononucleares do sangue periférico e células T CD8+, quando comparados aos indivíduos HIV negativos. Diante do exposto, o objetivo deste estudo foi avaliar a associação do comprimento dos telômeros de leucócitos em indivíduos infectados pelo HIV com deficiências cognitivas, pois ainda é um assunto bastante controverso. Métodos: Um total de 73 pacientes in

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12

Nakalawa, Lynda. "Perceptions of mental illness among HIV counselors in Uganda : a qualitative study." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/96131.

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Thesis (MPhil)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: The HIV/AIDS pandemic has led to millions of deaths; disability for the sufferers and multiple socioeconomic effects on HIV infected and affected individuals. Among the factors affecting people living with HIV/AIDS that may contribute to HIV related disability is mental illness such as HIV related manias and depression. ‘HIV counselors’ make up part of the team at the forefront of HIV treatment and management in Uganda but little is known about their perceptions of mental illness. This study therefore sought to explore th

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13

Alexandrou, Estella. "The therapeutic effect of LIF in EAE-associated axonal injury." Connect to thesis, 2009. http://repository.unimelb.edu.au/10187/5514.

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Axonal degeneration is a major pathological feature of the central nervous system (CNS) inflammatory demyelinating disease multiple sclerosis (MS). This axonal degeneration has major consequences, as functional axonal regeneration in the CNS is largely absent. Cumulative axonal degeneration is the likely cause of the majority of progressive MS-related disability, and therefore, the need for novel neuroprotective therapies for MS exists. Experimental autoimmune encephalomyelitis (EAE), an animal model of MS pathology, also produces axonal injury. In particular, the optic nerve and spinal cord

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14

Tavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.

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O Vírus da Imunodeficiência Humana (HIV) é o agente etiológico da Síndrome da Imunodeficiência Adquirida (AIDS). A AIDS é uma doença de distribuição mundial, e estima-se que existam atualmente pelo menos 36,9 milhões de pessoas infectadas com o vírus. Durante o seu ciclo replicativo, o HIV promove diversas alterações na fisiologia da célula hospedeira a fim de promover sua sobrevivência e potencializar a replicação. A rápida progressão da infecção pelo HIV-1 em humanos e em modelos animais está intimamente ligada à função da proteína acessória Nef. Dentre as diversas ações de Nef está a regula

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15

Clarke, Jennifer. "In vitro studies on HIV-1 infection of Astrocytes." 2007. http://hdl.handle.net/2440/59614.

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Title page, table of contents and summary only. The complete thesis in print form is available from the University of Adelaide Library.<br>HIV-1 infection of astrocytes is involved in HIV-1 induced neurological diseases and is a possible source of viral persistence. In situ studies of post mortem brain tissue indicate that HIV-1 infection of astrocytes does occur, but is restricted. Previous in vitro studies have revealed intrinsic intracellular blocks to HIV-1 transcription and translation in astrocytes. The early viral replication steps of entry, reverse transcription and integration have n

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16

Kirkby, Lana. "The neurocognitive effects of immunosupression in the AIDS dementia complex." Thesis, 2014. http://hdl.handle.net/10210/9448.

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17

Harilall, Sheri-Lee. "Formulation and evaluation of an implantable polymeric configuration for application in AIDS Dementia Complex." Thesis, 2011. http://hdl.handle.net/10539/10636.

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Drug delivery to the brain has challenged medical professionals for several decades, with 98% of small molecules and 100% of large molecules unable to cross the blood brain barrier (BBB). Biocompatible, biodegradable polymers have been extensively researched for the oral delivery of therapeutic agents, but to date has not been successfully manipulated for the formulation of an implantable device. We have therefore utilised such polymers for the formulation and design of an implantable nanoenabled multipolymeric drug delivery device (NMDDD) for the management of AIDS Dementia Complex (ADC). AD

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18

Zheve, Georgina Teurai. "Neuroprotective mechanisms of nevirapine and efavirenz in a model of neurodegeneration /." 2007. http://eprints.ru.ac.za/1350/.

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19

Pilon, Louise. "Profil et analyse des besoins des résidents d'une ressource d'hébergement spécialisé en VIH-SIDA, à partir du point de vue des intervenants." Thèse, 2005. http://hdl.handle.net/1866/15801.

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