Academic literature on the topic 'AIDS (Disease) – Treatment – Lesotho'

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Journal articles on the topic "AIDS (Disease) – Treatment – Lesotho"

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Cohen, Rachel, Sharonann Lynch, Helen Bygrave, Evi Eggers, Natalie Vlahakis, Katherine Hilderbrand, Louise Knight, et al. "Antiretroviral treatment outcomes from a nurse-driven, community-supported HIV/AIDS treatment programme in rural Lesotho: observational cohort assessment at two years." Journal of the International AIDS Society 12, no. 1 (February 2009): 23. http://dx.doi.org/10.1186/1758-2652-12-23.

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Hlalele, Dipane, and Puleng Relebohile Letsie. "Gender Inequality and HIV/AIDS in Lesotho: A Human Disease Ecological Perspective." Journal of Human Ecology 36, no. 3 (December 2011): 159–65. http://dx.doi.org/10.1080/09709274.2011.11906430.

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Koto, Masebeo Veronica, and Pranitha Maharaj. "Difficulties facing healthcare workers in the era of AIDS treatment in Lesotho." SAHARA-J: Journal of Social Aspects of HIV/AIDS 13, no. 1 (January 2016): 53–59. http://dx.doi.org/10.1080/17290376.2016.1179588.

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Kinney, Evlin L., Jean-Jacques Monsuez, Michel Kitzis, and Daniel Vittecoq. "Treatment of AIDS-Associated Heart Disease." Angiology 40, no. 11 (November 1989): 970–76. http://dx.doi.org/10.1177/000331978904001106.

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Volberding, Paul. "Treatment of malignant disease in AIDS patients." AIDS 2 (1988): S169–176. http://dx.doi.org/10.1097/00002030-198800001-00025.

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Navarro, Willis H., and Lawrence D. Kaplan. "AIDS-related lymphoproliferative disease." Blood 107, no. 1 (January 1, 2006): 13–20. http://dx.doi.org/10.1182/blood-2004-11-4278.

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Abstract Not long after the recognition of HIV as the causative agent of AIDS, it was evident that individuals infected with HIV developed lymphoma at a greater rate than the population at large. Approximately two thirds of AIDS-related lymphoma (ARL) cases are categorized as diffuse large B-cell type, with Burkitt lymphomas comprising 25% and other histologies a much smaller proportion. Typically, these individuals have presented with advanced extranodal disease and CD4+ lymphocyte counts of less than 200/mm3. Recent clinical trials have demonstrated a better outcome with chemotherapy for ARL since the introduction of combination antiretroviral treatment, termed highly active antiretroviral therapy (HAART). For patients with relapses, solid evidence points to the safety and utility of hematopoietic-cell transplantation as a salvage modality. Coinfection with other viruses such as Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus have led to the genesis of previously rare or unrecognized lymphoma subtypes such as plasmablastic and primary effusion lymphomas. The immunosuppressive impact of treatment for patients with ARL receiving chemotherapy with HAART appears transient and opportunistic infections have become less problematic than prior to HAART. Significant progress has been made in the understanding and management of ARL but outcomes still remain inferior compared to those achieved in HIV- individuals.
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Mönkemüller, Klaus E., and C. Mel Wilcox. "Diagnosis and Treatment of Colonic Disease in AIDS." Gastrointestinal Endoscopy Clinics of North America 8, no. 4 (October 1998): 889–911. http://dx.doi.org/10.1016/s1052-5157(18)30238-1.

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Lawrence, Janet S. St, and Michael R. Kauth. "AIDS phobia: Disease patterns and possibilities of treatment." Clinical Psychology Review 10, no. 5 (January 1990): 607–9. http://dx.doi.org/10.1016/0272-7358(90)90101-f.

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Richey, Lisa Ann. "Mobilizing for Global AIDS Treatment." Nordicom Review 33, Special-Issue (December 1, 2012): 29–43. http://dx.doi.org/10.2478/nor-2013-0023.

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Abstract Global communication about HIV/AIDS requires the creation of new communities that can bridge distances and distinctions of nationality, language, class, race, gendered-identities and other forms of local identification on a disease that is associated with the realm usually understood as private (sexuality). Global AIDS, characterized as ‘the disease of our time’, is responsible for spawning an entire industry devoted to the prevention, detection, treatment, and potential cure of HIV/AIDS. In terms of scale, this industry works primarily cross-nationally, with donors from the North funding programs for AIDS prevention and care in the South. Anti-retroviral drugs (ARVs), typically produced as generics by manufacturers in India or South Africa and purchased by aid funding, are central to global AIDS programs. Yet, mobilizing for global AIDS treatment embodies the logic of marketing, in which Africans with AIDS are sold as lives to be saved. This article will draw from international relations theory, sociology and anthropology to offer an interdisciplinary perspective on mobilizing communication globally.
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Bonacini, Maurizio, and Loren A. Laine. "Esophageal Disease in Patients with AIDS: Diagnosis and Treatment." Gastrointestinal Endoscopy Clinics of North America 8, no. 4 (October 1998): 811–23. http://dx.doi.org/10.1016/s1052-5157(18)30233-2.

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Dissertations / Theses on the topic "AIDS (Disease) – Treatment – Lesotho"

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Mphana, Mateboho Patricia. "HIV/AIDS prevention and care for learners in a higher education institution in Lesotho." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5307.

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Thesis (MCur (Interdisciplinary Health Sciences. Nursing Science))--University of Stellenbosch, 2010.
ENGLISH ABSTRACT: HIV/AIDS is considered as a global problem with the number of people living with HIV infection continuing to increase. At the end of 2007 HIV/AIDS had already claimed 25 million lives. Of all new HIV infections 71% were diagnosed in the Sub-Saharan region in 2008, remaining the worst affected region globally. UNAIDS (2008:43) indicated that heterosexual intercourse remained the main origin for HIV infection in the Sub-Saharan region. Therefore the researcher is of the opinion that prevention strategies should focus mainly on sexual transmission of the disease. HIV/AIDS affects mainly people between the ages 15-24 years, notably the age group of most of the learners in Higher Education Institutions (HEIs). Lesotho, a country in the Sub- Saharan region, presents with the third highest HIV adult prevalence (23.2%) in the world and in the region. In an attempt to address the prevailing situation, Lesotho has a number of programmes geared towards addressing HIV/AIDS in the country. However, all these attempts exclude the learners in HEIs, yet the majority of learners are found within the most affected age group. It is also to be noted that Higher Education provides the bedrock for socio-economic and political development in Africa. Some studies have identified insufficient knowledge as being at the root of the increasing HIV infections among youth. However, other studies have shown that there is adequate knowledge among the young people, but still a challenge remains and that is to facilitate changes in behavioural patterns as a component to be linked to the knowledge. Studies conducted in other African countries have shown that there are anti-AIDS programmes and clubs for learners in HEIs where learners are involved in the fight against HIV/AIDS. No publication indicating the same for Lesotho’s HEIs could be found, except for the National University of Lesotho (NUL) that only launched its HIV/AIDS policy for learners in 2009. The researcher is of the opinion that HEIs in Lesotho are not doing enough to combat HIV/AIDS and hence intends to focus on HEIs in Lesotho. This study had two objectives namely:  To determine the knowledge of learners in a specific HEI in Lesotho regarding HIV/AIDS prevention and care.  To explore the needs of learners in a specific HEI in Lesotho regarding HIV/AIDS prevention and care. This mixed method study was conducted, comprising of both quantitative and qualitative designs. Quantitative phase used a questionnaire for determining the knowledge of learners. The questionnaire was adopted from a study that was performed to determine knowledge of South African educators in public schools with some modifications. The qualitative phase was used to explore the needs of the learners through the focus group discussions with the leaders of the learners. Sample was drawn from the entire population using stratified random sampling for the quantitative phase. The qualitative phase used the purposive sampling to obtain in-depth information concerning learners’ needs. Quantitative data was analysed through the use of statistical package for social sciences (SPSS) and qualitative data was analysed using the thematic analysis and open-coding. All ethical principles were adhered to especially the principle of respect for persons. The findings from the quantitative phase of the study showed that learners had adequate knowledge regarding HIV/AIDS prevention and care and the findings from the qualitative phase showed the various needs of the learners with regards to prevention and care of HIV/AIDS in a specific HEI in Lesotho. Recommendations have been proposed based on the findings from the two phases of the study. Limitations observed by the researcher have also been identified. In conclusion the objectives of the study were met and the research questions had been answered.
AFRIKAANSE OPSOMMING: MIV/Vigs word as ‘n internasionale probleem erken, siende dat daar ‘n verhoging in die toename van MIVgeïnfekteerde indiwidue tans is . Einde 2007 het MIV/Vigs het reeds 25 miljoen lewens ge-eis . In 2008 is 71% van al die nuwe MIV-infeksies in die Sub-Sahara streek gediagnoseer, wat aandui dat die streek die mees geaffekteerde streek tans is. UNAIDS (2008:43) het aangedui dat heteroseksuele omgang die hoofoorsaak van MIV-oordrag in die Sub-Sahara-streek is. Laasgenoemde het daartoe gelei dat die navorser van mening is dat voorkomende strategieë meestal op seksuele oordrag van die siekte moet fokus. MIV/Vigs affekteer meestal mense in die ouderdomsgroep 15-24, opmerklik is dit die ouderdomsgroep waarby meesste leerders in Hoëronderwysinstellings (HOI) is. Lesotho, ‘n land in die Sub-Sahara-streek, het tans die derde-hoogste MIV-voorkoms (23.2%) in die wêreld en in die streek. Lesotho het verskeie programme ontlont om MIV/Vigs te bekamp in ‘n poging om die huidige situasie te beredder . Nieteenstaande sluit al die programme leerders in HOI uit, alhoewel die leerders in die ouderdomsgroep van die mees-geaffekteerde groep val. Dit is ook duidelik dat Hoëronderwys die fondasie vir sosio-ekonomiese- en politieke ontwikkeling in Afrika verskaf. Sommige studies het onvoldoende kennis as die wortel van die verhoging van MIV-infeksies onder die jeug geïdentifiseer. Ander studies, daarenteen, wys dat kennis voldoende is onder jeug, alhoewel veranderinge in gedragspatrone om by die kennis aan te sluit ‘n uitdaging bly. Studies uit ander Afrikalande dui daarop dat daar anti-Vigs programme en klubs is waarby HO leerders betrokke is om teen die verspreiding van MIV/Vigs te veg. Geen publikasies in hierdie verband word in Lesotho aangetref nie, behalwe ‘n MIV/Vigs-beleid wat in 2009 deur “National University of Lesotho’ (NUL) gepubliseer is. Dus is die navorser van mening dat HOI nie genoeg doen om MIV/Vigs te beveg nie, daarom fokus sy op HOI in Lesotho. Hierdie studie het twee doelstellings ten doel gehad, naamlik om die leerders in ‘n sekere HOI in Lesotho se kennis aangaande MIV/Vigs voorkoming en sorg te bepaal en die behoeftes van die leerders aangaande MIV/Vigs voorkoming en sorg te verken. ‘n Studie met beide kwantitatiewe- en kwalitatiewe metodes is gebruik om die doelstellings te verwesenlik. In die kwantitatiewe fase is ‘n vraelys gebruik om leerders se kennis te bepaal. Die vraelys is verkry uit ‘n vorige studie wat in RSA gedoen is, maar aangepas om in die Lesotho-konteks te gebruik. Gedurende die kwalitatiewe fase is fokusgroep besprekings met die leiers van die leerders gehou om die behoeftes indiepte te verken. Die steekproef was uit die totale populasie getrek deur van gestratifiseerde streekproefneming gebruik te maak in die kwantitatiewe fase en ‘n doelgerigte steekproefneming is in die kwalitatiewe fase te gebruik. Die navorser het ‘n kwantitatiewe data-analise sagteware (SPSS)gebruik om kwantitatiewe data te ontleed en tematiese- oopkodering is gedurende die kwalitatiewe fase gebruik. Etiese kode is ten volle gerespekteer, veral die respek vir mense gedurende navorsing. Bevindinge van die kwantitatiewe fase het bewys dat leerders voldoende kennis aangaande die voorkoming en sorg van MIV/Vigs besit en die kwalitatiewe bevindinge het die behoeftes van leerders met betrekking tot die voorkoming en sorg van MIV/Vigs in ‘n spesifieke HOI in Lesotho geopenbaar. Die aanbevelings is gemaak, gebaseer op die bevindinge uit die twee fases. Beperkinge in die studie is uitgelig. Ter afsluiting is die doelstellings in die studie bereik en die navorsingsvrae beantwoord.
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Mofokeng, Shoeshoe. "Views of health service providers on the need for support services for HIV-positive mothers in the rural areas of Lesotho : an ecological perspective." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96969.

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Thesis (M Social Work)--Stellenbosch University, 2015.
ENGLISH ABSTRACT: HIV/AIDS is one of the worst pandemics affecting the world today. It cuts across all boundaries and many people are infected as well as affected. The virus has reached all the corners of the globe, but the most hit by it is Africa, especially southern Africa, which carries more than half of the population infected and affected by HIV/AIDS. The top five countries whose populationsare infected with HIV are in southern Africa. Lesotho is amongst the top three on this list and also has problems of poverty and a high unemployment rate. Women and children, who are the target groups that are most affected by poverty, are also those living in rural areas. Thus, being an HIV-positive mother living in the rural areas of Lesotho means one has to deal with poverty, the inaccessibility of services and the psychological impacts of HIV. The aim of the study was to gain a better understanding of the views of health service providers on the need and accessibility of support services for HIV-positive mothers in the rural areas of Lesotho from an ecological perspective. To achieve this aim, the objectives were: to offer an overview of the phenomenon of HIV and describe the psychosocial needs and sociocultural circumstance of HIV-positive mothers in the rural areas of Lesotho, and to discuss the HIV-positive mothers’ need for support services from an ecological perspective. Both quantitative and qualitative research approaches were used. The research utilised exploratory and descriptive design. Purposive sampling was used to select the 30 participants who took part in the study. Data was gathered by means of semi-structured questionnaires that were administered during individual interviews. The questionnaires were formulated on the basis of information retrieved during the literature review. The findings of the study reveal that HIV-positive mothers living in the rural areas of Lesotho have economic, social and cultural circumstance as factors hindering their treatment and prevention of HIV/AIDS. They are also faced with the psychological impacts of HIV, and the findings revealed that disclosure was the key to addressing their problems. The findings also show that most mothers receivedemotional, instrumental, informational and appraisal support from their families at the micro-level of the ecological perspective. The other levels – meso, exo and macro – provided only limited support for the mothers. The recommendations are that these mothers need social support at all levels of the ecological perspective to meet their needs
AFRIKAANSE OPSOMMING: MIV/vigs is een van die ergste pandemies in die moderne wêreld. Dit ken geen grense nie, en vele mense ly hetsy daaraan of daaronder. Die virus het reeds alle uithoeke van die aarde bereik. Tog gaan Afrika, veral Suider-Afrika, die swaarste daaronder gebuk, en word meer as die helfte van die totale populasie wat aan of onder MIV/vigs ly hier aangetref. Die vyf lande met die hoogste MIV-infeksiesyfers ter wêreld is almal in die streek geleë. Lesotho is een van die drie lande boaan hierdie lys, en het terselfdertyd te kampe met die probleme van armoede en ’n hoë werkloosheidsyfer. Vroue en kinders, synde die groepe wat die ergste deur armoede geraak word, woon ook meestal in landelike gebiede. ’n MIV-positiewe moeder in die landelike gebiede van Lesotho moet dus armoede, ontoeganklike dienste sowel as die sielkundige uitwerking van MIV trotseer. Die doel van hierdie studie was om vanuit die ekologiese perspektief ’n beter begrip te vorm van gesondheidsdiensverskaffers se sienings oor die behoefte aan en toeganklikheid van steundienste vir MIV-positiewe moeders in die landelike gebiede van Lesotho. Om hierdie doel te bereik, was die oogmerke om ’n oorsig van die MIV-verskynsel te bied, die psigososiale behoeftes en sosiokulturele omstandighede van MIV-positiewe moeders in die landelike gebiede van Lesotho te beskryf, en die moeders se behoefte aan steundienste vanuit die ekologiese perspektief te bespreek. ’n Kwantitatiewe sowel as ’n kwalitatiewe navorsingsmetode is gevolg, en die navorser het van ’n verkennende en beskrywende ontwerp gebruik gemaak. Doelgerigte steekproefneming is gebruik om die 30 studiedeelnemers te kies. Data is met behulp van semigestruktureerde vraelyste gedurende individuele onderhoude ingesamel. Die vraelyste is opgestel op grond van inligting wat in die literatuuroorsig bekom is. Die studie bevind dat ekonomiese, maatskaplike en kulturele omstandighede MIV/vigs-behandeling en -voorkoming vir MIV-positiewe vroue in die landelike gebiede van Lesotho belemmer. Daarbenewens moet hulle die sielkundige uitwerking van MIV die hoof bied, en die studie dui op openbaarmaking as die sleutel om hul probleme te hanteer. Die bevindinge toon ook dat die meeste moeders emosionele, fisiese, inligting- en bevestigende steun van hul families op die mikrovlak van die ekologiese perspektief ontvang. Die ander vlakke – meso, ekso en makro – bied slegs beperkte steun. Die studie kom tot die gevolgtrekking dat hierdie moeders op alle vlakke van die ekologiese perspektief maatskaplike steun moet ontvang om in hul behoeftes te voorsien.
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Sekhibane, Veronica Mabohle. "The impact of HIV/AIDS among different organizations in Lesotho and how they respond to the challenge : a Lesotho study." Thesis, Stellenbosch : Stellenbosch University, 2005. http://hdl.handle.net/10019.1/50496.

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Thesis (MPhil)--Stellenbosch University,2005.
ENGLISH ABSTRACT: The aim of this research is to investigate the impact of HIV/AIDS among different organizations in Lesotho and how they respond to the challenge; and to determine whether these organizations respond positively/effectively to the challenge of the pandemic in their respective organizations and whether they have developed workplace programmes and policies which address the issue, and if they do exist, whether they are effective. Lesotho is one of the countries in the world with a very severe HIV/AIDS infection rate. It is estimated that 28.9% of the entire population was living with HIV/AIDS as of December 2003 (UNAIDS, 2004). The increasing number of HIV/AIDS infectees in the country is affecting the entire labour force; therefore to effectively respond to the pandemic, the government of Lesotho and its development partners and civil society organizations are doing everything within their means to control it. Therefore, work place programmes that deal with HIV/AIDS on the work environment should be an answer to the social capital issue; the most valuable resource being human capital, since the programmes would promote prevention, information, education and training. It would also promote the rights of staff members and their dependants living with and/or affected by the HIV/AIDS pandemic. The population where the investigation was done is made up of corporate places of work stratified into five types of organizations found in Maseru, the capital of Lesotho: o Non-governmental organizations o Private sector o Development partners ( Diplomatic Missions/Donors) o Parastatals o Government The results of the study indicated that the majority of these organizations have workplace programmes and policies which are effective and appreciated by the employees, while others are in the process of drawing up their policies or already have them in draft form. Despite all the efforts being put in place, the feeling among some of the organizations is that HIV infection in Africa will continue to increase because of the way it is being addressed; what they call ‘The Western way’. They feel that if it is addressed situationally, not academically, there will be a slight difference. For example, they claim that Africans do not feel comfortable about bringing their private behaviours in the open; for instance, speaking about sex and sexuality. The belief systems of the Basotho are also identified as great influencers in the pandemic. These include the culture/traditions, relations with the family and pressure from peers, people whom we trust and the fulfilment of women's sexual desires. The conclusion reached is that the different organizations in Lesotho address the challenge of HIV/AIDS positively and in others effectively, and with more effort the pandemic could be brought under control in the near future. The recommendation after viewing the findings, is that the issue of care and support, stigma and discrimination are still issues that need to be worked on, since employees are scared to know their status due to fear of being stigmatized. Therefore, the above cannot be addressed properly unless they are seen in practice.
AFRIKAANSE OPSOMMING: Die doel van hierdie studie is 'n ondersoek na die impak van MIV/Vigs op, en reaksie van verskillende ondernemings in Lesotho. Volgens beraming is die infeksiekoers van Lesotho 28.9% en is die invloed daarvan op die werkersmag beduidend; dit kan selfs katastofies raak indien dit nie doeltreffend aangespreek en bestuur word nie.. Data is versamel by by vyf kategorië van ondernemings in Maseru ten einde te verseker dat al die belangrikste sektore deur die studie betrek word.. Resultate toon aan dat die meeste ondernemings wel werksplekprogramme en MIV/Vigs-beleid in plek het. Die persepsie van werkers binne die ondernemings wat in die ondersoek gebruik is toon egter 'n negatiewe prognose ten opsigte van die doelteffende bestuur van die pandemie. Die gevoel is dat die benadering te reglynig en "Westers" is en dat die metafore en tradisies van Afrika meer effektief in voorkomingsprogramme sal wees. Voorstelle in hierdie verband word gemaak. Voorstelle vir meer doeltreffende voorkomingsprogramme word gemaak en voorstelle vir verdere studies in Lesotho word aan die hand gedoen.
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Diaho, Mahlao Judith. "Experiences and coping strategies of women living with HIV/AIDS diagnosis : a case study of Maseru, Lesotho." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/49959.

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Thesis (MPhil)--University of Stellenbosch, 2004.
ENGLISH ABSTRACT: Several studies have reported that thirty million people are living with HIV/AIDS in sub-Saharan Africa. Fifty percent of the infected adults are women aged between 15 and 49 years. In Lesotho, HIV/AIDS has also been declared a national emergency and an estimated 180,000 women out of 330,000 adults, and 27,000 children are living with HIV/AIDS. Statistics have shown that the majority of AIDS cases occur in adults aged 15 and 49 years in Lesotho. Presently women are the fastest growing infected population in Lesotho. Regardless of the growing numbers of women infected with HIV/AIDS, experiences of women living with HIV/AIDS have received little attention in Lesotho. Qualitative research in this area is necessary to gain access to women's perceptions of their HIV positive status. In this study, the experiences and coping strategies of Basotho women living with HIV/AIDS were investigated. The study used a feminist approach to research. Feminist research stresses the multiplicity of knowledge and it is useful to understand the subjective experiences of women. Indepth, face-to-face interviews were conducted with five women ranging between 29 and 46 years, purposefully drawn from Positive Action Society Lesotho (PASL). Grounded theory was used to analyse the data. Findings indicate that women's risk for exposure to HIV is related to their ability to protect themselves by negotiating a safe sexual relationship. Women who feel powerless in their relationships are less likely to protect themselves against HIVexposure. These perceptions of powerlessness are the result of a broad array of experiences that may include exposure to gender-based violence and restricted economic opportunities. The results show that it is common for women to be shocked, depressed, and discouraged when they find that they are living with HIV/AIDS as can be expected. It is also difficult for women to disclose their HIV positive status to family, friends and community members because of stigma attached to HIV/AIDS. Participants developed different ways of coping with their status such as religion, healthy life style, AIDS counselling and social networks. There was a profound sense of anxiety about the future care of children. The study concludes with a number of recommendations to promote an environment that will make it possible for women living with HIV/AIDS to cope with their illness.
AFRIKAANSE OPSOMMING: Studies het bevind dat daar ongeveer dertig miljoen mense in sub-Sahara Afrika is wat met MIVNIGS leef. Vyftig persent van geinfekteerde volwassenes is vroue tussen die ouderdom van 15-49 jaar. In Lesotho is MIVNIGS as 'n nasionale ramp verklaar en daar word beraam dat 330,000 volwassenes, 180,000 vroue en 27,000 kinders MIVNIGS het. Statistiek het ook getoon dat die meerderheid VIGS gevalle in Lesotho voorkom by volwassenes in die ouderdomsgroep 15-49 jaar. Vroue is tans die vinnigste groeiende groep. Ten spyte van die groeiende getalle vroue wat met MIVNIGS geinfekteer is, het die ervaringe van vroue in Lesotho wat met MIVNIGS saamleef tot dusver relatief min aandag geniet. Kwalitatiewe navorsing in hierdie verband is nodig om toegang tot vroue se persepsies te verkry rakende hul eie MIV positiewe status. In hierdie studie is die ervaringe en hanteringsmeganismes van Basoetoe vroue wat MIVNIGS het, ondersoek. Die studie het 'n feministiese benadering gebruik, wat die multiplisiteit van kennis en die subjektiewe ervaringe van vroue beklemtoon. In-diepte aangesig-tot-aangesig onderhoude is met vroue tussen 29-46 jaar gevoer. Gegronde teorie is gebruik om die data te analiseer. Bevindinge dui aan dat vroue se risiko vir blootstelling aan MIV verband hou met hul vermoë om hulself te beskerm deur te onderhandel vir 'n veilige seksuele verhouding met 'n maat. Vroue wat magteloos in hul verhoudings voel, is waarskynlik minder suksesvol om hulself teen MIV blootstelling te beskerm. Hierdie persepsies van magteloosheid is die resultaat van 'n breë spektrum ervaringe wat sekondêre status, blootstelling aan geweld, en beperkte ekonomiese geleenthede insluit. Soos wat verwag word, toon die bevindinge dat dit algemeen vir vroue is om geskok, deppressief en ontmoedig te wees wanneer hulle uitvind dat hul MIVNIGS het. Dit is ook moeilik vir vroue om hul MIV status aan familie, vriende en gemeenskapslede bekend te maak weens die stigma wat aan MIVNIGS kleef. Respondente het verskeie wyses ontwikkelom hul status te hanteer, soos godsdiens, 'n gesonde leefstyl, VIGS raadgewing en sosiale netwerke. Daar was ook 'n intense bekommernis by vroue oor die toekomstige sorg vir hul kinders. Die studie sluit af met 'n aantal aanbevelings om 'n omgewing te promoveer wat dit vir vroue wat met MIVNIGS leef moontlik sal maak om hul siekte te hanteer.
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Hoffmann, Toinette. "The right of the HIV/AIDS patient to treatment." Thesis, University of Port Elizabeth, 2001. http://hdl.handle.net/10948/277.

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The objective of this treatise is to establish whether a right to social security exists in South Africa, which would entitle HIV positive persons in South Africa citizens to medical care. A study was made of various articles in journals and on the Internet to determine the South African government's policy on a right to social security and to providing medical treatment. It was found that South Africa lacks an integrated, holistic approach to social security and does not guarantee the right to social security, merely the right to have access to social security. The same was found with the right to medical care. Although there seems to be a general right to medical care which extends to and includes HIV-positive patients, the state merely guarantees the right to apply for medical treatment but does not guarantee the granting thereof. It is submitted that the Department of Health's refusal to implement a vertical transmission prevention programme and the failure to offer treatment as an alternative, for whatever reason, is "penny wise and pound foolish". In the long run more money is spent dealing with pediatric AIDS. It was further found that although the government attempted to lay a groundwork with the formulation and acceptance of the national AIDS plan, the successful implementation thereof is seriously hindered due to the lack of inter- and intra-departmental collaboration, essential health services and funding.
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McKallip, Robert James. "The immunomodulatory properties of AZT used in the treatment of AIDS." Thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-06102009-063223/.

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Makhubele, Jabulani Calvin. "The impact of culture on the prevention and treatment of HIV/AIDS amongst people in low-resourced areas :a social work perspective." Thesis, University of Limpopo, 2004. http://hdl.handle.net/10386/2027.

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Thesis (M. A. (Social Work)) -- University of Limpopo, 2004.
The aim of this study was to explore the impact of culture on the prevention and reatment of HIV/AIDS amongst people in low-resourced areas like Malamulele. he study focused on the lifestyles, beliefs, attitudes and perceptions around ultural elements and practices, which might impact negatively on the prevention nd treatment of the HIV/AIDS epidemic. There were three groups of research espondents namely: learners from three high schools in Malamulele, some arents of the learners and the traditional/cultural leaders. The researcher ollected both qualitative and quantitative data. The data was gathered through he use of an interview schedule (questionnaire), focus group discussions and ound-table discussion sessions. The data was presented, analysed and nterpreted by means of tables and charts. t was found that people in low-resourced (rural) areas have little knowledge about HIV/AIDS, causes, symptoms and how the disease is transmitted. Despite the fact that awareness and educational campaigns and programmes are being rendered, people in low-resourced (rural) areas have little knowledge and needed skills about prevention and treatment of the pandemic. Polygamy and extra-marital relations by men is still highly valued and viewed at high esteem. Religious structures seem to be detached to the issue of HIV/AIDS as they mentioned that talking about HIV/AIDS is immoral and against their principles. The study also tried to explore the extent to which people in low-resourced areas view and use condoms as a protective means.
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Rushing, R. Mark. "An outpatient facility for the treatment of HIV/AIDS." Thesis, Georgia Institute of Technology, 1998. http://hdl.handle.net/1853/23302.

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Garanganga, Eunice. "Palliative care needs of children suffering from AIDS, Zimbabwe." Thesis, [S.l. : s.n.], 2009. http://dk.cput.ac.za/cgi/viewcontent.cgi?article=1030&context=td_cput.

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Walker, Blain S. "The diagnosis and treatment of major depression in AIDS patients : effect of counselor experience and attitude toward people with AIDS." Virtual Press, 1999. http://liblink.bsu.edu/uhtbin/catkey/1137581.

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This study was an investigation into the clinical judgments made by counseling psychologists when faced with a patient who had major depression and AIDS. Two hundred and eighty one counseling psychologists evaluated one of four vignettes depicting an individual with major depression. In three of the vignettes the individual also had AIDS but the vignette varied on how the virus was contracted (unprotected gay sex, IV drug abuse, hemophilia). In the fourth vignette (the control group) the individual did not have AIDS. Results of the study suggested, that the presence of AIDS overshadows the evaluation and treatment decisions made by counseling psychologists when their patient has major depression and AIDS. Three factors-counseling psychologists' general experience with people who have AIDS, their clinical experience with AIDS patients and how the AIDS virus was contracted-were investigated for possible moderating effects of the overshadowing bias. How the AIDS virus was contracted was used as an indirect measure of clinician attitude toward people with AIDS. Neither general or clinical experience with AIDS patients appeared to have an effect on the diagnostic or treatment decisions made by counseling psychologists when evaluating depressed patients with AIDS. As with experience, method of contracting the AIDS virus did not have a moderating effect on the overshadowing bias. Implications of these results for the evaluation and treatment of depression in AIDS patients, as well as future research are discussed.
Department of Counseling Psychology and Guidance Services
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Books on the topic "AIDS (Disease) – Treatment – Lesotho"

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Hall, David. Participatory learning review of the Paballong HIV/AIDS Centre, Ha Senekane, Lesotho. Maseru: Sechaba Consultants, 2009.

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Lefa, Thamae, and Phaqane Mofihli, eds. Analysis of traditional healers in Lesotho: Implications on intellectual property systems. Nairobi, Kenya: African Technology Policy Studies Network, 2012.

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Maw, Moe Aung. HIV/AIDS and STD situation in Lesotho. Maseru, Lesotho: STD/HIV/AIDS Prevention and Control Programme, Disease Control and Environmental Health Division, Ministry of Health & Social Welfare, 2000.

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S, James John, and James John S. AIDS treatment news. Berkeley, Calif: Celestial Arts, 1989.

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(Organization), Family Health International. HIV/AIDS behavioral surveillance survey: Lesotho 2002 : summary technical report-- round 1. Maseru]: Family Health International, 2002.

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Letsie, Puleng. Bukana ea HIV/AIDS: Bakeng sa baetapele ba sechaba : Lesotho. Lesotho: Caesars Distributers, 2004.

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Kane, Brigid M. HIV/AIDS treatment drugs. Edited by Triggle D. J. New York NY: Chelsea House, 2011.

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Kane, Brigid M. HIV/AIDS treatment drugs. New York, NY: Chelsea House, 2008.

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Linda, Anderson. Progress on the treatment of AIDS. [Bethesda, Md.?]: National Cancer Institute, Office of Cancer Communications, 1987.

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M, Ismail S. Homoeopathy, an anti-aids treatment. New Delhi: Mittal Publications, 1990.

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Book chapters on the topic "AIDS (Disease) – Treatment – Lesotho"

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Capeau, J., M. Caron, and F. Boccara. "Pathogenesis of Antiretroviral Treatment-Associated Metabolic Syndrome." In Cardiovascular Disease in AIDS, 33–53. Milano: Springer Milan, 2009. http://dx.doi.org/10.1007/978-88-470-0761-1_3.

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Dittmer, Dirk P., and Blossom Damania. "KSHV-Associated Disease in the AIDS Patient." In Cancer Treatment and Research, 129–39. Boston, MA: Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-46816-7_4.

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Boccara, F., C. Meuleman, S. Ederhy, S. Lang, S. Janower, A. Cohen, and F. Raoux. "Coronary Artery Disease in HIV-Infected Patients: ClinicalPresentation,Pathophysiology, Prognosis,Prevention,and Treatment." In Cardiovascular Disease in AIDS, 111–29. Milano: Springer Milan, 2009. http://dx.doi.org/10.1007/978-88-470-0761-1_9.

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Busch, Katie A., and Sarz Maxwell. "Somatic Treatment of Psychiatric Symptoms in HIV Disease." In Behavioral Aspects of AIDS, 267–78. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4757-9386-4_15.

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Miller, David. "Diagnosis and Treatment of Acute Psychological Problems Related to HIV Infection and Disease." In Behavioral Aspects of AIDS, 187–206. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4757-9386-4_11.

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Dittmer, Dirk P., and Blossom Damania. "Kaposi’s Sarcoma-Associated Herpesvirus (KSHV)-Associated Disease in the AIDS Patient: An Update." In Cancer Treatment and Research, 63–80. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-03502-0_3.

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Wilson, Anika. "“Nobody Fears Aids, Mphutsi is More Fire”: Disease Rumors in the Age of Aids Treatment." In Folklore, Gender, and Aids in Malawi, 91–118. New York: Palgrave Macmillan US, 2013. http://dx.doi.org/10.1057/9781137322456_4.

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"Nutrients and Treatment of Heart Disease in AIDS." In AIDS and Heart Disease, 214–22. CRC Press, 2004. http://dx.doi.org/10.3109/9780203021897-14.

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Bruce, R. Douglas, Frederick L. Altice, and Gerald Friedland. "HIV Disease Among Substance Users: Treatment Issues." In Global HIV/AIDS Medicine, 513–26. Elsevier, 2008. http://dx.doi.org/10.1016/b978-1-4160-2882-6.50048-4.

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"Chapter 18. HIV/AIDS Prevention and Treatment." In Disease Control Priorities in Developing Countries (2nd Edition), edited by Dean T. Jamison, Joel G. Breman, Anthony R. Measham, George Alleyne, Mariam Claeson, David B. Evans, Prabhat Jha, Anne Mills, and Philip Musgrove, 331–70. World Bank Publications, 2006. http://dx.doi.org/10.1596/978-0-8213-6179-5/chpt-18.

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Conference papers on the topic "AIDS (Disease) – Treatment – Lesotho"

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Lobis, Yusuf Bachtiyar, Bhisma Murti, and Hanung Prasetya. "Influences of Peer Support Group and Psychosocio- Economic Determinants on Treatment Compliance in Hiv/Aids Patients in Sragen, Central Java." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.02.59.

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Background: Adherence to treatment is important to reduce viral replication, improve clinical and immunological conditions, reduce the risk of developing ARV resistance, and reduce the risk of HIV transmission. Peer support is suspected to be one of the factors driving drug intake adherence in patients with chronic disease. This study aimed to examine the influences of peer support and psychosocio-economic determinants on treatment compliance in HIV/AIDS patients. Subjects and Method: This was a case control design study conducted in Sragen, Central Java, Indonesia. A sample of 200 people with HIV/AIDS (PLWH) was selected by fixed disease sampling. The dependent variable was treatment compliance. The independent variables were knowledge toward HIV/AIDS, perceived benefit, perceived belief, perceived threat, perceived susceptibility, perceived seriousness, perceived barrier, attitude, indirect experience, family support, and peer support. The data were obtained from medical record and questionnaire. The data were analyzed by a multiple logistic regression run on Stata 13. Results: Treatment compliance increased with strong peer support (b= 1.34; 95% CI= 0.31 to 2.38; p= 0.011), strong family support (b= 1.09; 95% CI= 0.16 to 2.02; p= 0.021), knowledge toward HIV/AIDS (b= 1.65; 95% CI= 0.67 to 2.64; p= 0.001), high perceived benefit (b= 1.23; 95% CI= 0.28 to 2.18; p= 0.011), perceived belief (b= 2.05; 95% CI= 0.98 to 3.12; p<0.001), and high perceived threat (b= 1.22; 95% CI= 0.30 to 2.13; p= 0.009). Treatment compliance decreased with negative attitude (b= -2.47; 95% CI= -3.58 to -1.37; p <0.001), low perceived susceptibility (b= -1.26; 95% CI= -2.24 to – 0.27; p= 0.012), low perceived seriousness (b= -1.11; 95% CI= -2.06 to -0.16; p=0.021), high perceived barrier (b= -1.76; 95% CI= -2.81 to -0.70; p= 0.001), and indirect experience (b= -1.10; 95% CI= -2.05 to -0.14; p= 0.024). Conclusion: Treatment compliance increases with strong peer support, strong family support, high knowledge toward HIV/AIDS, high perceived benefit, perceived belief, and high perceived threat. Treatment compliances decrease with negative attitude, low perceived susceptibility, low perceived seriousness, high perceived barrier, and indirect experience. Keywords: HIV/AIDS, treatment compliance, peer support, psychosocial economy Correspondence: Yusuf Bachtiyar Lobis. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: bachtiyar03@gmail.com. Mobile: +628111388841. DOI: https://doi.org/10.26911/the7thicph.02.59
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Takahashi, Hoyu, Wataru Tatewaki, Reizo Nagayama, Masaharu Hanano, Shin-ichiro Takizawa, and Akira Shibata. "HEAT-TREATED FACTOR VIII CONCENTRATES IN VON WILLEBRAND'S DISEASE AND RELATED DISORDERS: STUDIES IN PLATELET-TYPE VON WILLEBRAND'S DISEASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644118.

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Cryoprecipitate has proved to correct the hemostatic defects in von Willebrand1s disease (vWd). However, recent studies have revealed that transmission of the AIDS retrovirus (HIV) occurs through exposure to blood products including cryoprecipitate. Treatment with heat-treated factor VIII concentrates may have certain advantages over treatment with non-heated products, if these preparations are efficacious in vWd and related disorders. We investigated the multimeric compositoin of von Willebrand factor (vWf), contents of vWf antigen (vWf:Ag) and ristocetin cofactor activity (RCof) in the heat-treated factor VIII concentrates and cryoprecipitate, and their capacity to directly induce aggregation of platelet-type (or pseudo-) vWd platelets in vitro. The vWf multimers were visualized by a newly developed, immuno-enzymatic staining of the gel, following a discontinuous SDS-agarose gel electrophoresis. The RCof/vWf:Ag ratio was around 1.0 in cryoprecipitate, and ranged from 0.19 to 0.96 in factor VIII concentrates. Among four commercially available concentrates studied, Haemate P contained the most high-molecular-weight multimers of vWf and the highest RCof relative to vWf:Ag, and induced the aggregation of platelet-type vWd platelets at the lowest concentration. When infused into a patient with platelet-type vWd, Haemate P (144 units vWf:Ag/kg body weight) shortened the prolonged bleeding time and caused spontaneous platelet aggregation in vitro with a mild diminution of platelet count (from the preinfusion value of 183,000μl to 139,000μl at 5 minutes). These results indicate that some of the heat-treated factor VIII concentrates contain the high-molecular-weight vWf multimers and may provide a safer, yet still effective, treatment for platelet-type vWd, and possibly for various types of vWd as well.
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Caulk, Alexander W., and Rudolph L. Gleason. "Treatment With Non-Nucleoside Reverse Transcriptase Inhibitor Efavirenz Leads to Increase of Carotid Intima-Media Thickness in Mice." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14744.

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Since the advent of highly active antiretroviral therapy (HAART), patients infected with human immunodeficiency virus-1 (HIV-1) are living longer lives. However, HIV-1-positive (HIV-1+) patients are now experiencing many non-AIDS related comorbidities including myocardial infarction, atherosclerotic lesions, and other preclinical markers of atherosclerosis including increased carotid intima-media thickness (cIMT), arterial stiffness, and impaired flow-mediated dilation (FMD). Studies have implicated the virus, the treatment, or both in the progression of these co-morbidities, causing the exact mechanisms of cardiovascular disease progression to remain unclear.
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Hansen, Laura, Manu Platt, Roy L. Sutliff, and Rudolph L. Gleason. "The Mechanical and Structural Effects of HIV Proteins on Murine Carotid Arteries." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53693.

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Acquired immunodeficiency syndrome (AIDS) is considered a global epidemic with over 65 million people worldwide infected with the HIV-1 virus, the causative agent [1]. The development of highly active antiretroviral therapy (HAART) has significantly increased the life expectancy of people infected with the virus by slowing the progression to the development of AIDS. However, the treatment has also led to the emergence of early onset cardiovascular complications including myocardial infarction [2] and atherosclerotic lesions [3], as well as subclinical markers of atherosclerosis including increased carotid artery intima-media thickness [4], increased arterial stiffness [5–6], and endothelial dysfunction [6]. It appears that HAART and HIV-1-infection are independent risk factors for the development of atherosclerosis in adults [7]; however, the mechanism of disease progression remains unclear. There is a pressing need to identify mechanisms of early on-set cardiovascular disease associated with HIV-1 infection and HAART and to identify therapeutic strategies to reduce cardiovascular disease in HIV patients. The overall goal of this study is to test the hypothesis that over-expression of HIV proteins will lead to alterations in the biomechanical properties of large arteries.
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Tareq HAMMOODI, Zeyad. "CORONA EPIDEMIC (COVD 19) BETWEEN SHARIA AND MEDICINE." In International Research Congress of Contemporary Studies in Social Sciences (Rimar Congress 2). Rimar Academy, 2021. http://dx.doi.org/10.47832/rimarcongress2-7.

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The Corona epidemic is a wide group of viruses that include viruses that can cause a group of illnesses in humans, ranging from the common cold to severe acute respiratory syndrome, as there is no definitive and specific treatment for the epidemic. The medicines used are helpful and supportive, and they mostly aim to reduce the patient’s temperature with the use of pulmonary resuscitation devices, as the body’s resistance depends on autoimmunity, as it is the main factor in preventing this epidemic, and here we must know the role of medical and forensic scholars in preventing and treating With what appears from this epidemic and other epidemics, we do not know when and how they will appear to the world. The emergence of this disease is an extension of several diseases before it and the so-called (contemporary diseases), which are contagious communicable diseases, including bird flonza disease, swine flonza, sass and AIDS, mad cow disease, Ebola, human papillomavirus, herpes simplex virus, yellow fever, and many others These diseases are epidemic.
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Hyun, Sinjae, Sun Jin Moon, and Chong S. Kim. "Computational Modeling of Aerosol Deposition Characteristics in Cyclic Bifurcating Tube Flow." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19169.

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An accurate model of the human respiratory system allows health scientists to gain insight into the interactions between particulate matter (PM) and the exposed surfaces of the lung airways. Respiratory dose simulations and modeling are frequently used for evaluating health effects of inhaled toxic substances [1–4] and for analyzing the risk potentials of inhaled toxic or harmful PM such as vehicle emissions [4,5]. Pharmaceutical companies and pulmonologists find it useful in evaluating efficacy of inhaled medicinal aerosols and devising new patient treatment regimen [6–8], especially in vulnerable population groups such as children, industrial workers, and the elderly [10]. Recently, the respiratory system has seen increased attention as a possible venue for drug delivery to fight diseases such as AIDS, diabetes, and various cancers, among others. Computational fluid dynamics modeling and simulation continues to be an important tool for understanding of delivery of pharmaceutical aerosols to the lung airways and thereby improving treatment of airway disease, particularly, asthma with bronchodilators and corticosteroids inhalers [11,12].
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Hanks, Bradley W., Mary Frecker, and Matthew Moyer. "Design of a Compliant Endoscopic Ultrasound-Guided Radiofrequency Ablation Probe." In ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/detc2016-59923.

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Pancreatic cancer is one of the most deadly forms of cancer in the United States. Due to its late diagnosis, only 20% of patients diagnosed with the disease are eligible for surgical resection which is considered the preferred method of treatment. Radiofrequency ablation is a common cancer treatment modality for patients ineligible for open surgery. There is a lack of ablation probes which may be used to generate spherical heating zones which closely match the geometry of typical tumors. In particular, there are no endoscopic ablation probes commercially available in the United States. In this paper the design of a compliant endoscopic radiofrequency ablation probe is presented. This probe features an array of compliant tines which deploy through the cancerous tissue to effectively broaden the ablation zone. A thermal ablation model is used to inform the design of the geometry of the probe. In addition, finite element analysis is used to determine the feasibility of the compliant structures. These design tools are used as aids to inform the design and direct modifications toward a feasible probe which generates a spherical ablation zone.
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Pangerti, Fitria Diyah Ayu, Pawito Pawito, and Hanung Prasetya. "Factors Affecting Adherence to Antiretroviral Therapy: Application of Theory of Planned Behavior in Malang, East Java." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.02.53.

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Background: Adherence to antiretroviral (ARV) treatment is known as an important component in achieving the success of an optimal HIV therapy program. Poor adherence to antiretroviral therapy (ART) is associated with less effective viral suppression, which creating permanent treatment resistance. The purpose of this study was to examine factors affecting adherence to ARV therapy. Subjects and Method: A cross-sectional study was conducted in Malang, East Java, from September to October 2019. A sample of 200 PLWH was selected by fixed disease sampling. The dependent variable was adherence to ARV therapy. The independent variables were cues to action, perceived susceptibility, perceived benefit, attitude, and CST service. The data were collected by medical record and questionnaire. The data were analyzed by a multiple linear regression. Results: Adherence to ARV therapy in PLWH increased with strong cues to action (OR= 6.40; 95% CI= 3.13 to 13.12; p<0.001), strong perceived susceptibility (OR= 3.61; 95% CI= 1.82 to 7.13; p<0.001), strong perceived benefit (OR= 4.68; 95% CI= 2.37 to 9.28; p<0.001), and positive attitude (OR= 5.39; 95% CI= 2.69 to 10.83; p<0.001). CST service was associated with adherence to ARV therapy but it was statistically non-significant (OR= 0.63; 95% CI= 0.33 to 1.20; p=0.130). Conclusion: Adherence to ARV therapy in PLWH increases with strong cues to action, strong perceived susceptibility, strong perceived benefit, and positive attitude. CST Keywords: Care, support, and treatment service, people living with HIV/AIDS Correspondence: Fitria Diyah Ayu Pangerti. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: ayupangerti13@yahoo.com. Mobile: 081332600710. DOI: https://doi.org/10.26911/the7thicph.02.53
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9

Jugl, Sebastian, Aimalohi Okpeku, Brianna Costales, Earl Morris, Golnoosh Alipour-Harris, Juan Hincapie-Castillo, Nichole Stetten, et al. "A Mapping Literature Review of Medical Cannabis Clinical Outcomes and Quality of Evidence in Approved Conditions in the United States, from 2016 to 2019." In 2020 Virtual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2021. http://dx.doi.org/10.26828/cannabis.2021.01.000.25.

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Background: Medical cannabis is available to patients by physician order in two-thirds of the United States (U.S.) as of 2020, but remains classified as an illicit substance by federal law. States that permit medical cannabis ordered by a physician typically require a diagnosed medical condition that is considered qualifying by respective state law. Objectives: To identify and map the most recently (2016-2019) published clinical and scientific literature across approved conditions for medical cannabis, and to evaluate the quality of identified recent systematic reviews. Methods: Literature search was conducted from five databases (PubMed, Embase, Web of Science, Cochrane, and ClinicalTrials.gov), with expansion and update from the National Academies of Sciences, Engineering, and Medicine’s (NASEM) comprehensive evidence review through 2016 of the health effects of cannabis on several conditions. Following consultation with experts and stakeholders, 11 conditions were identified for evidence evaluation: amyotrophic lateral sclerosis (ALS), autism, cancer, chronic pain, Crohn’s disease, epilepsy, glaucoma, HIV/AIDS, multiple sclerosis (MS), Parkinson’s disease, and posttraumatic stress disorder (PTSD). The following exclusion criteria were imposed: preclinical focus, non-English language, abstracts only, editorials/commentary, case studies/series, and non-U.S. study setting. Data extracted from studies included: study design type, outcome, intervention, sample size, study setting, and reported effect size. Studies classified as systematic reviews with or without meta-analysis were graded using the AMSTAR-2 tool by two raters to evaluate the quality of evidence, with additional raters to resolve cases of evidence grade disagreement. Results: A total of 438 studies were included after screening. Five completed randomized controlled trials (RCTs) were identified, and an additional 11 trials were ongoing, and 1 terminated. Cancer, chronic pain, and epilepsy were the most researched topic areas, representing more than two-thirds of all reviewed studies. The quality of evidence assessment for each condition suggests that few high-quality systematic reviews are available for most conditions, with the exceptions of MS, epilepsy, and chronic pain. In those areas, findings on chronic pain are mostly in alignment with the previous literature, suggesting that cannabis or cannabinoids are potentially beneficial in treating chronic neuropathic pain. In epilepsy, findings suggest that cannabidiol is potentially effective in reducing seizures in pediatric patients with drug-resistant Dravet and Lennox-Gastaut syndromes. In MS, recent high-quality systematic reviews did not include new RCTs, and are therefore not substantially expanding the evidence base. In sum, the most recent clinical evidence suggests that for most of the conditions assessed, we identified few studies of substantial rigor and quality to contribute to the evidence base. However, there are some conditions for which significant evidence suggests that select dosage forms and routes of administration likely have favorable risk-benefit ratios (i.e., epilepsy and chronic pain), with the higher quality of evidence for epilepsy driven by FDA-approved formulations for cannabis-based seizure treatments. Conclusion: The body of evidence for medical cannabis requires more rigorous evaluation before consideration as a treatment option for many conditions and evidence necessary to inform policy and treatment guidelines is currently insufficient for many conditions.
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