Relevant bibliographies by topics / Airway epithelium

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Airway epithelium'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 July 2024

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Journal articles on the topic "Airway epithelium"

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Burch, L. H., C. R. Talbot, M. R. Knowles, C. M. Canessa, B. C. Rossier, and R. C. Boucher. "Relative expression of the human epithelial Na+ channel subunits in normal and cystic fibrosis airways." American Journal of Physiology-Cell Physiology 269, no. 2 (August 1, 1995): C511—C518. http://dx.doi.org/10.1152/ajpcell.1995.269.2.c511.

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The availability of the newly cloned subunits (alpha, beta, gamma) of the epithelial Na+ channel (ENaC) permits molecular studies of the pathogenesis of the abnormal Na+ transport rates of cystic fibrosis (CF) airway epithelia. Northern analyses of airway epithelia showed that both normal and CF airway epithelia express ENaC subunit mRNAs in a ratio of alpha > beta > gamma. In situ hybridization studies revealed expression of all three ENaC subunits in the superficial epithelium and the alpha- and beta-subunits in the gland ductular and acinar epithelium of both normal and CF airways. Ri
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Inoue, Hideki, Kaho Akimoto, Tetsuya Homma, Akihiko Tanaka, and Hironori Sagara. "Airway Epithelial Dysfunction in Asthma: Relevant to Epidermal Growth Factor Receptors and Airway Epithelial Cells." Journal of Clinical Medicine 9, no. 11 (November 18, 2020): 3698. http://dx.doi.org/10.3390/jcm9113698.

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Airway epithelium plays an important role as the first barrier from external pathogens, including bacteria, viruses, chemical substances, and allergic components. Airway epithelial cells also have pivotal roles as immunological coordinators of defense mechanisms to transfer signals to immunologic cells to eliminate external pathogens from airways. Impaired airway epithelium allows the pathogens to remain in the airway epithelium, which induces aberrant immunological reactions. Dysregulated functions of asthmatic airway epithelium have been reported in terms of impaired wound repair, fragile ti
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White, Steven R. "Apoptosis and the Airway Epithelium." Journal of Allergy 2011 (December 13, 2011): 1–21. http://dx.doi.org/10.1155/2011/948406.

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The airway epithelium functions as a barrier and front line of host defense in the lung. Apoptosis or programmed cell death can be elicited in the epithelium as a response to viral infection, exposure to allergen or to environmental toxins, or to drugs. While apoptosis can be induced via activation of death receptors on the cell surface or by disruption of mitochondrial polarity, epithelial cells compared to inflammatory cells are more resistant to apoptotic stimuli. This paper focuses on the response of airway epithelium to apoptosis in the normal state, apoptosis as a potential regulator of
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Sparrow, M. P., H. W. Mitchell, and T. I. Omari. "The epithelial barrier and airway responsiveness." Canadian Journal of Physiology and Pharmacology 73, no. 2 (February 1, 1995): 180–90. http://dx.doi.org/10.1139/y95-027.

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Epithelial injury and bronchial hyperresponsiveness are commonly associated with airway disease, and are widely considered to occur as the result of inflammatory changes in the airway wall. Mechanistically, the airway epithelium may influence the sensitivity of the airways to provocative stimuli through its primary function as a cellular barrier between the air and the interstitium, or by liberating a variety of bronchoactive mediators, e.g., lipoxygenase and cyclooxygenase products, nitric oxide, and an epithelium-derived relaxing factor (EpDIF). Much attention has focused on the latter funct
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Gallos, George, Elizabeth Townsend, Peter Yim, Laszlo Virag, Yi Zhang, Dingbang Xu, Matthew Bacchetta, and Charles W. Emala. "Airway epithelium is a predominant source of endogenous airway GABA and contributes to relaxation of airway smooth muscle tone." American Journal of Physiology-Lung Cellular and Molecular Physiology 304, no. 3 (February 1, 2013): L191—L197. http://dx.doi.org/10.1152/ajplung.00274.2012.

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Chronic obstructive pulmonary disease and asthma are characterized by hyperreactive airway responses that predispose patients to episodes of acute airway constriction. Recent studies suggest a complex paradigm of GABAergic signaling in airways that involves GABA-mediated relaxation of airway smooth muscle. However, the cellular source of airway GABA and mechanisms regulating its release remain unknown. We questioned whether epithelium is a major source of GABA in the airway and whether the absence of epithelium-derived GABA contributes to greater airway smooth muscle force. Messenger RNA encod
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Vanoni, Simone, Giada Scantamburlo, Silvia Dossena, Markus Paulmichl, and Charity Nofziger. "Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia." International Journal of Molecular Sciences 20, no. 3 (February 9, 2019): 731. http://dx.doi.org/10.3390/ijms20030731.

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Pendrin (SLC26A4), a Cl−/anion exchanger, is expressed at high levels in kidney, thyroid, and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride reabsorption, iodide accumulation, and endolymph ion balance, respectively. Pendrin is expressed at lower levels in other tissues, such as airways and esophageal epithelia, where it is transcriptionally regulated by the inflammatory cytokines interleukin (IL)-4 and IL-13 through a signal transducer and activator of transcription 6 (STAT6)-mediated pathway. In the airway epithelium, increased pendrin expression during
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Hyde, Dallas M., David J. Magliano, and Charles G. Plopper. "Morphometric Assessment of Pulmonary Toxicity in the Rodent Lung." Toxicologic Pathology 19, no. 4_part_1 (November 1991): 428–46. http://dx.doi.org/10.1177/0192623391019004-112.

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An overview of the epithelial and interstitial composition of rat respiratory airways shows complexity and variability. Airway epithelium varies in 1) different airway levels; 2) the types and ultrastructure of cells present; and 3) the abundance, type, and composition of stored secretory product. Unbiased sampling of airways is done using airway microdissection with a specific binary numbering system for airway generation. Vertical sections of selected airways are used to sample epithelium and interstitium. We determine the ratios of the volume of epithelial or interstitial cells to the total
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Dey, R. D., J. B. Altemus, I. Zervos, and J. Hoffpauir. "Origin and colocalization of CGRP- and SP-reactive nerves in cat airway epithelium." Journal of Applied Physiology 68, no. 2 (February 1, 1990): 770–78. http://dx.doi.org/10.1152/jappl.1990.68.2.770.

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A combination of neuroanatomic techniques was used to examine the origin and neuropeptide content of nerve fibers in the airway epithelium of adult cats. By the use of immunocytochemical methods, the peptides substance P (SP) and calcitonin gene-related peptide (CGRP) were colocalized in airway epithelial nerve fibers. Two days after wheat germ agglutinin (WGA) was injected into the nodose ganglion, fibers containing WGA immunoreactivity (IR) were detected in the airway epithelium. SP-like immunoreactivity (LI) and CGRP-LI were demonstrated separately in the WGA-IR fibers, establishing their o
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Flodby, Per, Janice M. Liebler, Mitsuhiro Sunohara, Dan R. Castillo, Alicia M. McConnell, Manda S. Krishnaveni, Agnes Banfalvi, et al. "Region-specific role for Pten in maintenance of epithelial phenotype and integrity." American Journal of Physiology-Lung Cellular and Molecular Physiology 312, no. 1 (January 1, 2017): L131—L142. http://dx.doi.org/10.1152/ajplung.00005.2015.

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Previous studies have demonstrated resistance to naphthalene-induced injury in proximal airways of mice with lung epithelial-specific deletion of the tumor-suppressor gene Pten, attributed to increased proliferation of airway progenitors. We tested effects of Pten loss following bleomycin injury, a model typically used to study distal lung epithelial injury, in conditional PtenSFTPC-cre knockout mice. Pten-deficient airway epithelium exhibited marked hyperplasia, particularly in small bronchioles and at bronchoalveolar duct junctions, with reduced E-cadherin and β-catenin expression between ce
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Soleas, John P., Ana Paz, Paula Marcus, Alison McGuigan, and Thomas K. Waddell. "Engineering Airway Epithelium." Journal of Biomedicine and Biotechnology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/982971.

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Airway epithelium is constantly presented with injurious signals, yet under healthy circumstances, the epithelium maintains its innate immune barrier and mucociliary elevator function. This suggests that airway epithelium has regenerative potential (I. R. Telford and C. F. Bridgman, 1990). In practice, however, airway regeneration is problematic because of slow turnover and dedifferentiation of epithelium thereby hindering regeneration and increasing time necessary for full maturation and function. Based on the anatomy and biology of the airway epithelium, a variety of tissue engineering tools
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Dissertations / Theses on the topic "Airway epithelium"

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Shebani, Eyman. "Ultrastructural Studies of the Airway Epithelium in Airway Diseases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6632.

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Stevens, Paul. "Intrinsic differences of the airway epithelium in childhood allergic asthma." University of Western Australia. School of Paediatrics and Child Health, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0022.

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[Truncated abstract] Asthma affects millions of people worldwide and places a substantial burden on the healthcare system. Despite advances in our understanding of disease mechanisms and the role of respiratory viruses in asthma exacerbations, there is little known regarding the role of the epithelium in commonly observed structural changes in the airway wall. The epithelium of the airways provides an essential protective barrier between the environment and underlying structures and is responsible for the secretion of diverse compounds. Since it is likely that dysregulated epithelial character
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Scull, Margaret Adele Pickles Raymond J. "Myxovirus interaction with the human airway epithelium." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2848.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Jun. 4, 2010). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.
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Wang, Jiahua. "The role of airway epithelium in airway inflammation and effect of corticosteroids." Thesis, Queen Mary, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300175.

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Rowley, Jessica. "The interaction of Aspergillus fumigatus with the respiratory epithelium." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-interaction-of-aspergillus-fumigatus-with-the-respiratory-epithelium(0fc10449-977d-4f14-a169-172e8204fee4).html.

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Aspergillus fumigatus is a filamentous fungus and the main pathogen responsible for the often fatal respiratory condition, aspergillosis. Airway epithelial cells (AECs) are likely to be the first line of host defence that come into contact with the inhaled conidia of A. fumigatus. Recent evidence strongly suggests that the response of the airway epithelium to inhaled pathogens is pivotal in orchestrating immune responses by inducing phagocytic-like reactions and the secretion of inflammatory cytokines and antimicrobial peptides. However, the majority of previous work investigating A. fumigatus
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Fox, Emma. "Systemic delivery of DNA to the airway epithelium." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409742.

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Leahy, Rachel A. "Signal Transduction and Cellular Differentiation in Airway Epithelium." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1352673026.

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FORTNER, CHRISTOPHER NEIL. "EPITHELIUM-DEPENDENT RELAXATION OF AIRWAY SMOOTH MUSCLE IS LINKED TO EPITHELIAL CHLORIDE CURRENTS." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin983467525.

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Williams, M. T. S. "Impact of different CFTR Mutations on Airway Epithelium Function." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527902.

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Jing, Yi. "Epithelial mechanisms in airway responses induced by hyperosmolarity." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5054.

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Thesis (Ph. D.)--West Virginia University, 2007.<br>Title from document title page. Document formatted into pages; contains xiv, 155 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
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Books on the topic "Airway epithelium"

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1954-, Farmer Stephen G., and Hay, Douglas W. P., 1956-, eds. The airway epithelium: Physiology, pathophysiology, and pharmacology. New York: Marcel Dekker, 1991.

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1954-, Farmer Stephen G., and Hay, Douglas W. P., 1956-, eds. The Airway epithelium: Physiology, pathophysiology, and pharmacology. New York: M. Dekker, 1991.

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Houghton, Shelagh Anne. The effect of vasoactive intestinal peptide on chloride conductance in airway epithelial cells. [New Haven, Conn: s.n.], 1997.

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Widdicombe, Jonathan. Airway Epithelium. Morgan & Claypool Life Science Publishers, 2012.

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Widdicombe, Jonathan. Airway Epithelium. Morgan & Claypool Life Science Publishers, 2012.

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Pintelon, Isabel, Jean-Pierre Timmermans, Inge Brouns, Line Verckist, and Dirk Adriaensen. Pulmonary Neuroepithelial Body Microenvironment: A Multifunctional Unit in the Airway Epithelium. Springer International Publishing AG, 2021.

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Li Bassi, Gianluigi, and J. D. Marti. Chest physiotherapy and tracheobronchial suction in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0121.

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The airway lining fluid is a biphasic layer covering the respiratory tract epithelium. It has antimicrobial and immunomodulatory properties, and it is formed by a gel-phase (mucus), and a low-viscosity inner layer (sol-phase) that provides lubrication for ciliary beating. Mucus is continuously cleared from the airways through the ciliated epithelium and via the two-phase gas–liquid flow mechanism (i.e. coughing). Mucus production in healthy subjects is approximately 10–100 mL/day. Whereas, mucociliary clearance rates range between 4 and 20 mm/min. Critically-ill, mechanically-ventilated patien
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Harrison, Mark. Respiratory physiology. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198765875.003.0033.

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This chapter describes respiratory physiology as it applies to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter outlines the key details of lung volumes and pressures, lung epithelium, lung compliance, surfactant, airway resistance, gas transfer, gas transport within circulation, control of respiration, and ventilation–perfusion relationship. This chapter is laid out exactly following the RCEM syllabus, to allow easy reference and consolidation of learning.
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Relova, Anne-Jacqueline. Mechanisms for & Effects of Airway Epithelial Damage in Ashthma. Uppsala Universitet, 2002.

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Burn, Mellisa. The regulation of airway epithelial function by adenosine and related nucleotides. 2005.

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Book chapters on the topic "Airway epithelium"

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Braga, P. C., L. Allegra, and G. Piatti. "Damage to Airway Epithelium." In Lungscapes, 77–92. Milano: Springer Milan, 1992. http://dx.doi.org/10.1007/978-88-470-2255-3_7.

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Mullol, Joaquim, James N. Baraniuk, Cesar Picado, and James H. Shelhamer. "Endothelin and the Airway Epithelium." In Pulmonary Actions of the Endothelins, 155–76. Basel: Birkhäuser Basel, 1999. http://dx.doi.org/10.1007/978-3-0348-8821-9_9.

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Idris, Tahir, Marc Chanson, and Mehdi Badaoui. "Biology of the CF Airway Epithelium." In Hodson and Geddes' Cystic Fibrosis, 48–58. 5th ed. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003262763-6.

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Henricks, Paul A. J., Ferdi Engels, Betty van Esch, Henk J. van der Linde, Moira J. Oosthuizen, and Frans P. Nijkamp. "Epithelium-Derived Linoleic Acid Metabolites Modulate Airway Smooth Muscle Function." In Mediators in Airway Hyperreactivity, 283–86. Basel: Birkhäuser Basel, 1990. http://dx.doi.org/10.1007/978-3-0348-7379-6_39.

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Bartlett, Jennifer A., Anthony J. Fischer, and Paul B. Jr McCray. "Innate Immune Functions of the Airway Epithelium." In Contributions to Microbiology, 147–63. Basel: KARGER, 2008. http://dx.doi.org/10.1159/000136349.

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Skerrett, Shawn J. "Toll-Like Receptors in the Airway Epithelium." In Mucosal Immunology of Acute Bacterial Pneumonia, 125–38. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5326-0_5.

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Mitchell, H. W., K. E. Willet, and M. P. Sparrow. "The Role of Epithelium in the Responsiveness of the Bronchi to Stimuli." In Mediators in Airway Hyperreactivity, 275–78. Basel: Birkhäuser Basel, 1990. http://dx.doi.org/10.1007/978-3-0348-7379-6_37.

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Puchelle, Edith, Jean-Marie Zahm, Sophie de Bentzmann, and Dominique Gaillard. "Mucus and Airway Epithelium Alterations in Cystic Fibrosis." In Airway Mucus: Basic Mechanisms and Clinical Perspectives, 301–26. Basel: Birkhäuser Basel, 1997. http://dx.doi.org/10.1007/978-3-0348-8874-5_12.

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Jones, Rosemary. "The Glycoproteins of Secretory Cells in Airway Epithelium." In Novartis Foundation Symposia, 175–201. Chichester, UK: John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720356.ch9.

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Reynolds, Susan D., Moumita Ghosh, Heather M. Brechbuhl, Shama Ahmad, and Carl W. White. "Stem and Progenitor Cells of the Airway Epithelium." In Stem Cells in the Respiratory System, 1–23. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-775-4_1.

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Conference papers on the topic "Airway epithelium"

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Koo, J., C. Kim, J. Lee, K. Kim, and J. Yoon. "Regeneration of Airway Epithelium Using Autologous Epithelial Cells." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2012.

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De, Bishnu P., Lindsay Lief, Michelle R. Staudt, Jennifer Fuller, Neil R. Hackett, Timothy Wilson, Maryna Elnasher, Matthew S. Walters, and Ronald G. Crystal. "Smoking Accelerates Airway Epithelial Aging: Smoking-Dependent Decrease In Small Airway Epithelium Telomere Length." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4123.

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Cohn, Lauren E., Karin Provost, Robert J. Homer, Naiqian Niu, and Charlotte Andreasen. "IFN-³ Acts On The Airway Epithelium To Regulate Allergic Airway Inflammation." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2485.

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Gallos, George, Sarah Zaidi, Peter Yim, Yi Zhang, Lazlo Virag, Robert Whittington, and Charles Emala. "Airway Epithelium Is The Predominant Cellular Source Of Endogenous Airway GABA." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6455.

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Kotnala, S., J. A. Gimenes, H. Reddy Vari, N. Owuor, N. Xander, W. Li, and U. Sajjan. "FOXO3A Regulates Antiviral Responses in Airway Epithelium." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5753.

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Hansi, R. K., G. K. Singhera, T. Shaipanich, D. D. Sin, D. R. Dorscheid, and J. M. Leung. "Respiratory Syncytial Virus Induces Epithelial Permeability in COPD and HIV Airway Epithelium." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3650.

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Meuchel, Lucas W., Elizabeth A. Townsend, Michael A. Thompson, Stephen D. Cassivi, and Y. S. Prakash. "Neurotrophins Produce Nitric Oxide In Human Airway Epithelium." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5550.

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Legebeke, Jelmer, Katie Horton, Gabrielle Wheway, Htoo Wai, Claire Jackson, Janice Coles, John Holloway, Jane Lucas, and Diana Baralle. "Transcriptome analysis of ciliary differentiation in airway epithelium." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.pa2398.

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Koliana, Marianne, Ernie Wong, David J. Jackson, Tatiana Kebadze, Carine Blanchard, Sebastian L. Johnston, Elaine Holmes, and Gary Frost. "Presence of airway SCFAs in asthma and response of airway epithelium to SCFAs." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa2379.

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Schamberger, Andrea, Fien Verhamme, Michael Lindner, Jürgen Behr, and Oliver Eickelberg. "Transcriptome analysis of the human airway epithelium duringin vitrodifferentiation." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa3993.

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Reports on the topic "Airway epithelium"

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Tierney, L. A., C. Bloomfield, and N. F. Johnson. Expression of a TGF-{beta} regulated cyclin-dependent kinase inhibitor in normal and immortalized airway epithelial cells. Office of Scientific and Technical Information (OSTI), December 1995. http://dx.doi.org/10.2172/381389.

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Zuraw, Bruce L. Epithelial Cell TRPV1-Mediated Airway Sensitivity as a Mechanism for Respiratory Symptoms Associated with Gulf War Illness?". Fort Belvoir, VA: Defense Technical Information Center, June 2010. http://dx.doi.org/10.21236/ada536752.

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Pacheco-Ojeda, Luis, Carolina Sáenz-Gómez, Stalin Cañizares-Quisiguiña, Tatiana Borja-Herrera, Juan Carlos Vallejo-Garzón, and Sergio Poveda. Function Sparing Conservative Approach of a Low-Grade Chondrosarcoma of the Larynx: Case Report and Literature Review. Science Repository, March 2024. http://dx.doi.org/10.31487/j.scr.2024.01.04.

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Background: Laryngeal cancer is relatively uncommon in Ecuador. Usually epithelial in origin, the most frequent histological type is squamous cell carcinoma. The most common mesenchymal tumor is chondrosarcoma. Most laryngeal chondrosarcomas are treated with total laryngectomy, but a conservative function sparing resection is recommended in low-grade limited tumors. Case Report: In a 68-year-old female nonsmoker patient, a small tumor was found in the posterior left aspect of the cricoid cartilage in a computed tomography (CT) performed immediately after an unexpected difficulty to pass the en
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High-fat Western diet alters silica-induced airway epithelium ion exchange but not airway smooth muscle reactivity (dataset). U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, May 2023. http://dx.doi.org/10.26616/nioshrd-1068-2023-0.

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