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Journal articles on the topic 'Airway (Medicine) Muscles Physiology Sex differences'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 January 2023

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1

Chang, Herng-Yu Sucie, and Wayne Mitzner. "Sex differences in mouse models of asthma." Canadian Journal of Physiology and Pharmacology 85, no. 12 (December 2007): 1226–35. http://dx.doi.org/10.1139/y07-116.

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Differences in disease susceptibility and prognosis between men and women are known to occur in the incidence and development of neurodegenerative, cardiovascular, and immunological disorders. In the lung there are also sex-based differences in the incidence, prevalence, and pathogenesis of lung cancer, cystic fibrosis, COPD, and asthma. In the general population, sex-based differences in asthma have been shown by epidemiologic studies, but unfortunately these studies are not consistent in their conclusions. This variability in human epidemiological studies justifies the need for more focused

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Kalidhindi, Rama Satyanarayana Raju, Niyati A. Borkar, Nilesh Sudhakar Ambhore, Christina M. Pabelick, Y. S. Prakash, and Venkatachalem Sathish. "Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19?" American Journal of Physiology-Lung Cellular and Molecular Physiology 319, no. 5 (November 1, 2020): L843—L847. http://dx.doi.org/10.1152/ajplung.00391.2020.

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The incidence, severity, and mortality of ongoing coronavirus infectious disease 19 (COVID-19) is greater in men compared with women, but the underlying factors contributing to this sex difference are still being explored. In the current study, using primary isolated human airway smooth muscle (ASM) cells from normal males versus females as a model, we explored the effect of estrogen versus testosterone in modulating the expression of angiotensin converting enzyme 2 (ACE2), a cell entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Using confocal imaging, we found tha

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Dominelli, Paolo B., and Yannick Molgat-Seon. "Sex, gender and the pulmonary physiology of exercise." European Respiratory Review 31, no. 163 (January 12, 2022): 210074. http://dx.doi.org/10.1183/16000617.0074-2021.

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In this review, we detail how the pulmonary system's response to exercise is impacted by both sex and gender in healthy humans across the lifespan. First, the rationale for why sex and gender differences should be considered is explored, and then anatomical differences are highlighted, namely that females typically have smaller lungs and airways than males. Thereafter, we describe how these anatomical differences can impact functional aspects such as respiratory muscle energetics and activation, mechanical ventilatory constraints, diaphragm fatigue, and pulmonary gas exchange in healthy adults

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Kalidhindi, Rama Satyanarayana Raju, Nilesh Sudhakar Ambhore, Premanand Balraj, Taylor Schmidt, M. Nadeem Khan, and Venkatachalem Sathish. "Androgen receptor activation alleviates airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma." American Journal of Physiology-Lung Cellular and Molecular Physiology 320, no. 5 (May 1, 2021): L803—L818. http://dx.doi.org/10.1152/ajplung.00441.2020.

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Epidemiological studies demonstrate an apparent sex-based difference in the prevalence of asthma, with a higher risk in boys than girls, which is reversed postpuberty, where women become more prone to asthma than men, suggesting a plausible beneficial role for male hormones, especially androgens as a regulator of pathophysiology in asthmatic lungs. Using a murine model of asthma developed with mixed allergen (MA) challenge, we report a significant change in airway hyperresponsiveness (AHR), as demonstrated by increased thickness of epithelial and airway smooth muscle layers and collagen deposi

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Ford, Lincoln E. "Plasticity in airway smooth muscle: an update." Canadian Journal of Physiology and Pharmacology 83, no. 10 (October 1, 2005): 841–50. http://dx.doi.org/10.1139/y05-089.

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At a similar meeting 10 years ago, we proposed (i) that the long functional range of some smooth muscles is accommodated by plastic alterations that place more myofilaments in series at longer lengths, (ii) that this plasticity is facilitated by myosin filament evanescence, with filaments dissociating partially during relaxation and reforming upon activation, and (iii) that filament lengthening during the rise of activation would cause velocity to fall. Since that meeting, we have accumulated a substantial body of evidence to support these proposals, as follows: (i) muscles develop nearly the

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Card, Jeffrey W., James W. Voltz, Catherine D. Ferguson, Michelle A. Carey, Laura M. DeGraff, Shyamal D. Peddada, Daniel L. Morgan, and Darryl C. Zeldin. "Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulation." American Journal of Physiology-Lung Cellular and Molecular Physiology 292, no. 4 (April 2007): L908—L914. http://dx.doi.org/10.1152/ajplung.00407.2006.

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A sex disparity in airway responsiveness to cholinergic stimulation has been observed in laboratory mice in that males are considerably more responsive than females, but the basis for this difference is unclear. In this report, we demonstrate that male sex hormones promote murine airway responsiveness to cholinergic stimulation via vagus nerve-mediated reflex mechanisms. In tissue bath preparations, no sex-based differences were observed in the contractile responses of isolated tracheal and bronchial ring segments to carbachol, indicating that the mechanism(s) responsible for the in vivo sex d

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Kurti, Stephanie P., Sam R. Emerson, Joshua R. Smith, Sara K. Rosenkranz, Samantha A. Alexander, Garrett M. Lovoy, and Craig A. Harms. "Older women exhibit greater airway 8-isoprostane responses to strenuous exercise compared with older men and younger controls." Applied Physiology, Nutrition, and Metabolism 43, no. 5 (May 2018): 497–503. http://dx.doi.org/10.1139/apnm-2017-0565.

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Development of late-onset respiratory diseases is associated with elevated 8-isoprostane, a marker of oxidative stress, in the airways. However, sex differences exist in development of these diseases. Using an exhaustive exercise bout as a physiological stressor may elucidate whether there is a sex difference with aging in pre- to postexercise airway 8-isoprostane generation. The purpose of this study was to determine whether older women exhibit a greater airway 8-isoprostane response to exhaustive exercise compared with older men and younger controls. Thirty-six individuals completed the stud

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8

Salminen, A., P. Saari, and M. Kihlström. "Age- and sex-related differences in lipid peroxidation of mouse cardiac and skeletal muscles." Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 89, no. 4 (January 1988): 695–99. http://dx.doi.org/10.1016/0305-0491(88)90310-0.

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9

Pascoe, Christopher D., Sujata Basu, Jacquie Schwartz, Mario Fonseca, Shana Kahnamoui, Aruni Jha, Vernon Dolinsky, and Andrew J. Halayko. "Maternal diabetes promotes offspring lung dysfunction and inflammation in a sex-dependent manner." American Journal of Physiology-Lung Cellular and Molecular Physiology 322, no. 3 (March 1, 2022): L373—L384. http://dx.doi.org/10.1152/ajplung.00425.2021.

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Exposure to maternal diabetes is increasingly recognized as a risk factor for chronic respiratory disease in children. It is currently unclear; however, whether maternal diabetes affects the lung health of male and female offspring equally. This study characterizes the sex-specific impact of a murine model of diet-induced gestational diabetes (GDM) on offspring lung function and airway inflammation. Female adult mice are fed a high-fat (45% kcal) diet for 6 wk prior to mating. Control offspring are from mothers fed a low-fat (10% kcal) diet. Offspring were weaned and fed a chow diet until 10 w

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Stock, Matt S., Dustin J. Oranchuk, Adam M. Burton, and David C. Phan. "Age-, sex-, and region-specific differences in skeletal muscle size and quality." Applied Physiology, Nutrition, and Metabolism 45, no. 11 (November 2020): 1253–60. http://dx.doi.org/10.1139/apnm-2020-0114.

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Ultrasonography-derived cross-sectional area (CSA) and echo intensity (EI) are increasingly utilized by investigators to study muscle size and quality, respectively. We sought to examine age, sex, and region (proximal, middle, distal) differences in vastus lateralis and rectus femoris CSA and EI, and determine whether correction for subcutaneous fat thickness influences the magnitude of EI differences. Fifteen younger men (mean age = 23 years), 15 younger women (aged 21 years), 11 older men (aged 74 years), and 15 older women (aged 70 years) participated. Clear differences were observed among

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Lal, Charitharth Vivek, Jegen Kandasamy, Kalsang Dolma, Manimaran Ramani, Ranjit Kumar, Landon Wilson, Zubair Aghai, et al. "Early airway microbial metagenomic and metabolomic signatures are associated with development of severe bronchopulmonary dysplasia." American Journal of Physiology-Lung Cellular and Molecular Physiology 315, no. 5 (November 1, 2018): L810—L815. http://dx.doi.org/10.1152/ajplung.00085.2018.

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The pathogenesis of bronchopulmonary dysplasia (BPD) is not well understood. We previously identified differences in the airway microbiome at birth between preterm infants who were BPD predisposed versus those who were BPD resistant. In this study, we attempted to identify mechanisms by which the airway microbiome could modify the risk for BPD. We used a software-based method to predict the metagenome of the tracheal aspirate (TA) microbiome from 16S rRNA sequencing data in preterm infants and to identify functional ortholog genes that were differentially abundant in BPD-predisposed and BPD-re

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Yuri, Saori, Frida Madeni, Eri Shishido, and Shigeko Horiuchi. "Early adolescents’ knowledge of anatomy, sexual characteristics and contraception from reproductive health education in Bagamoyo, Tanzania: a cross-sectional study." African Journal of Midwifery and Women's Health 16, no. 4 (October 2, 2022): 1–11. http://dx.doi.org/10.12968/ajmw.2021.0033.

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Background/Aims Adolescent girls in Tanzania may drop out of school if they experience an unwanted pregnancy. Evidence shows that sex education can improve adolescents’ understanding of issues related to intercourse, pregnancy and contraception, but this education is lacking in Tanzania. In order to improve sex education in Tanziania, this study investigated early adolescents’ knowledge of anatomy, changes during puberty, pregnancy, contraception and safety. Methods This cross-sectional study was conducted among randomly selected 10−14-year-old students in a primary school in Bagamoyo, Tanzani

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Guenette, Jordan A., Andrea M. Martens, Anne L. Lee, Gradin D. Tyler, Jennifer C. Richards, Glen E. Foster, Darren E. R. Warburton, and A. William Sheel. "Variable effects of respiratory muscle training on cycle exercise performance in men and women." Applied Physiology, Nutrition, and Metabolism 31, no. 2 (April 1, 2006): 159–66. http://dx.doi.org/10.1139/h05-016.

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Respiratory muscle training (RMT) has been proposed as an effective means to increase the strength of the inspiratory muscles and improve exercise performance. The purpose of this study was to examine the effect of RMT on cycling time to exhaustion (TTE) and to determine any potential sex effect. We hypothesized that RMT would improve maximal inspiratory pressure (MIP) and TTE to a similar degreee in men and women. Males (n = 7; mean (± SD) age, 22.1 ± 1.5 y) and females (n = 8; mean (± SD) 24.5 ± 4.9 y) performed an incremental cycle test to determine maximal oxygen consumption ([Formula: see

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Sanchez, Otto A., Elizabeth A. Copenhaver, Marti A. Chance, Michael J. Fowler, Theodore F. Towse, Jane A. Kent-Braun, and Bruce M. Damon. "Postmaximal contraction blood volume responses are blunted in obese and type 2 diabetic subjects in a muscle-specific manner." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 2 (August 2011): H418—H427. http://dx.doi.org/10.1152/ajpheart.00060.2011.

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The purpose of this study was to determine whether there are differences in postisometric contraction blood volume and oxygenation responses among groups of type 2 diabetes mellitus (T2DM), obese, and lean individuals detectable using MRI. Eight T2DM patients were individually matched by age, sex, and race to non-T2DM individuals with similar body mass index (obese) and lean subjects. Functional MRI was performed using a dual-gradient-recalled echo, echo-planar imaging sequence with a repetition time of 1 s and at two echo times (TE = 6 and 46 ms). Data were acquired before, during, and after

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Shafiq, Mamoona, Erum Afaq, Tooba Zafar, Mehwish Qamar, Saima Qureshi, and Amna Faruqi. "Exogenous Progesterone Produces Significant Histomorphological Changes in the Lungs of Experimental BALB/c Mice." Pakistan Journal of Medical and Health Sciences 16, no. 8 (August 30, 2022): 338–41. http://dx.doi.org/10.53350/pjmhs22168338.

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Background: Progesterone is used in combined oral contraceptive pills and also has its effect on the respective receptors which are responsible for sexual development. Bronchial asthma emerges to be a major health issue in Pakistan with estimated prevalence is about 5% of the total population. Epidemiological studies highlight that one of the considerable risk factor for morbidity and mortality in inflammatory lung diseases is female gender. This suggests that sex-related hormones might play an imperative role in asthma disease progression. Understanding the biological role of sex hormones in

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Tang, Rosalind, Abigail Fraser, and Maria Christine Magnus. "Female reproductive history in relation to chronic obstructive pulmonary disease and lung function in UK biobank: a prospective population-based cohort study." BMJ Open 9, no. 10 (October 2019): e030318. http://dx.doi.org/10.1136/bmjopen-2019-030318.

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ObjectivesSex differences in respiratory physiology and predilection for developing chronic obstructive pulmonary disease (COPD) have been documented, suggesting that female sex hormones may influence pathogenesis. We investigated whether aspects of female reproductive health might play a role in risk of COPD among women.DesignPopulation-based prospective cohort study.SettingUK Biobank recruited across 22 centres in the UK between 2006 to 2010.Primary and secondary outcomes measuresWe examined a range of female reproductive health indicators in relation to risk of COPD-related hospitalisation/

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Petrov, M. E., K. Hasanaj, C. M. Hoffmann, D. R. Epstein, L. Krahn, J. G. Park, K. Hollingshead, et al. "0695 Sleepwell24, A Smartphone Application To Promote PAP Therapy Adherence: Feasibility And Acceptability." Sleep 43, Supplement_1 (April 2020): A265. http://dx.doi.org/10.1093/sleep/zsaa056.691.

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Abstract Introduction We aimed to test the feasibility and acceptability of SleepWell24, a multicomponent, smartphone-delivered intervention to increase positive airway pressure (PAP) adherence among newly diagnosed OSA patients. Methods SleepWell24 targets PAP adherence along with other health behaviors through education, trouble-shooting, goal-setting, and near real-time biofeedback of PAP machine use, and sleep and physical activity levels (via Fitbit integration), and other chronic disease self-management components. Patients with a first-time diagnosis of OSA (AHI≥5) and prescribed PAP th

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LEWIS, P., and K. D. O’HALLORAN. "Sex Differences in Murine Sternohyoid Muscle Tolerance of Acute Severe Hypoxic Stress." Physiological Research, October 15, 2016, 843–51. http://dx.doi.org/10.33549/physiolres.933169.

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Given that sex differences inherent to muscle might at least contribute to male risk for obstructive sleep apnoea syndrome (OSAS), our objective was to test the hypothesis that male sternohyoid muscle exhibits greater susceptibility to severe hypoxic stress compared with female muscle. Adult male and female C57Bl6/J mouse sternohyoid isometric and isotonic functional properties were examined ex vivo at 35 °C in tissue baths under control and severe hypoxic conditions. Hypoxia was detrimental to peak force (Fmax), work (Wmax) and power (Pmax), but not shortening velocity (Vmax). Two-way analysi

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Ekpruke, Carolyn Damilola, and Patricia Silveyra. "Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors." Frontiers in Allergy 3 (April 29, 2022). http://dx.doi.org/10.3389/falgy.2022.875295.

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Asthma is characterized by an increase in the contraction and inflammation of airway muscles, resulting in airflow obstruction. The prevalence of asthma is lower in females than in males until the start of puberty, and higher in adult women than men. This sex disparity and switch at the onset of puberty has been an object of debate among many researchers. Hence, in this review, we have summarized these observations to pinpoint areas needing more research work and to provide better sex-specific diagnosis and management of asthma. While some researchers have attributed it to the anatomical and p

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Mann, Leah M., Sarah A. Angus, Connor J. Doherty, and Paolo B. Dominelli. "Evaluation of sex-based differences in airway size and the physiological implications." European Journal of Applied Physiology, July 31, 2021. http://dx.doi.org/10.1007/s00421-021-04778-2.

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Lesnick, Jason, Yefei Zhang, Justin X. Moore, Mohamud R. Daya, Jeffrey W. Jarvis, Graham Nichol, Jestin N. Carlson, et al. "Abstract 02: Effect of Airway Insertion First-Pass Success Upon Patient Outcomes in the Pragmatic Airway Resuscitation Trial." Circulation 140, Suppl_2 (November 19, 2019). http://dx.doi.org/10.1161/circ.140.suppl_2.02.

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Introduction: The multicenter Pragmatic Airway Resuscitation Trial (PART) demonstrated better adult out-of-hospital cardiac arrest (OHCA) outcomes with initial laryngeal tube (LT) insertion than endotracheal intubation (ETI) airway management. While emphasized in clinical practice, the effect of advanced airway insertion first-pass success (FPS) upon outcomes after OHCA is unknown. We sought to determine the direct and indirect mediating effects of LT and ETI FPS upon adult OHCA in a secondary analysis of PART. HYPOTHESES: 1) FPS associated with adult OHCA outcomes. 2) FPS mediates (explains)

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Kurz, Michael C., David Prince, J. Christenson, J. Carlson, S. May, D. Stub, S. Cheskes, et al. "Abstract 277: Supraglottic Airway Use Is Associated with Higher Chest Compression Fraction than Endotracheal Intubation During Out-of-Hospital Cardiopulmonary Arrest." Circulation 130, suppl_2 (November 25, 2014). http://dx.doi.org/10.1161/circ.130.suppl_2.277.

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Objective: Chest compression interruptions - such as those from endotracheal intubation (ETI) - are associated with poorer out-of hospital cardiac arrest (OHCA) survival. Select Emergency Medical Services (EMS) practitioners substitute ETI with supraglottic airway (SGA) insertion to minimize these interruptions, but the resulting effects upon chest compression fraction (CCF) are unknown. We sought to determine the differences in CCF between adult OHCA receiving ETI and those receiving SGA. Methods: We studied adult, non-traumatic OHCA patients enrolled in the Resuscitation Outcomes Consortium

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Novák, P., G. Zachařová, and T. Soukup. "Individual, age and sex differences in fiber type composition of slow and fast muscles of adult Lewis rats: comparison with other rat strains." Physiological Research, 2010, 783–801. http://dx.doi.org/10.33549/physiolres.931827.

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We analyzed fiber type composition of soleus and extensor digitorum longus (EDL) muscles of 3- to 19-month-old male and female inbred Lewis rats using histochemical demonstration of mATPase activity. The rats were divided into four groups of the mean age of 3, 6, 9 and 14 months. We found that the soleus muscle of 3-month-old rats contained significantly more of fast 2A fibers and less of slow type 1 fibers compared to older rats, while no significant difference was found between female and male rats at any age group. In contrast, we found no significant difference in the EDL fiber type compos

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Lupton, Joshua, Robert Schmicker, Mohamud Daya, Tom Aufderheide, Shannon Stephens, Nancy Le, Graham Nichol, Henry Wang, and Matthew Hansen. "Abstract 165: Association of Advanced Airway Placement and Time to Epinephrine Administration in Patients With Out-of-Hospital Cardiac Arrest." Circulation 138, Suppl_2 (November 6, 2018). http://dx.doi.org/10.1161/circ.138.suppl_2.165.

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Introduction: Out-of-hospital cardiac arrest (OHCA) remains a significant source of morbidity and mortality in the United States. In addition to cardiopulmonary resuscitation (CPR) and defibrillation, epinephrine and advanced airway management are often used in treatment. Recent studies suggest early administration of epinephrine is associated with improved survival. The purpose of this study was to evaluate the effect of airway type on timing to epinephrine in OHCA. Hypothesis: Patients who had laryngeal tube (LT) insertion as first attempted airway have shorter times to epinephrine administr

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Chang, Hansol, Jin Ho Choi, and DAUN JEONG. "Abstract 11045: Pre-Hospital Airway for Out-of-Hospital Cardiac Arrest: A Nationwide Multicenter Study." Circulation 144, Suppl_2 (November 16, 2021). http://dx.doi.org/10.1161/circ.144.suppl_2.11045.

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Introduction: This study investigated whether use of pre-hospital advanced airway management (AAM) is associated with improved survival of adults with out-of hospital cardiac arrest (OHCA) compared to conventional bag-valve-mask ventilation (BVM). Method: The study subjects were derived from Korean Cardiac Arrest Research Consortium (KoCARC), a multi-center OHCA registry of Korea. Patients who underwent AAM or BVM using supraglottic airway, oropharyngeal airway, or endotracheal intubation were compared. The differences in baseline clinical characteristics were adjusted using propensity scoring

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Bonette, Austin, Tom P. Aufderheide, Graham Nichol, Jeffrey Jarvis, Matthew L. Hansen, Riccardo Colella, Jason Lesnick, Jestin N. Carlson, Shannon W. Stephens, and Henry E. Wang. "Abstract 201: Bougie-Assisted Endotracheal Intubation in the Pragmatic Airway Resuscitation Trial." Circulation 142, Suppl_4 (November 17, 2020). http://dx.doi.org/10.1161/circ.142.suppl_4.201.

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Objective: Paramedics often perform endotracheal intubation (ETI) in the management of out-of-hospital cardiac arrest (OHCA). While ETI assisted by use of the gum elastic Bougie has been associated with improved first-pass intubation success in the emergency department, its influence upon out-of-hospital cardiac arrest (OHCA) ETI is unknown. We compared success rates and outcomes between Bougie-assisted and standard ETI in the Pragmatic Airway Resuscitation Trial (PART). Methods: We conducted a secondary analysis of PART, a clinical trial comparing initial-ETI vs. initial-laryngeal tube airway

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Konrad, Andreas, Masatoshi Nakamura, Florian K. Paternoster, Markus Tilp, and David G. Behm. "A comparison of a single bout of stretching or foam rolling on range of motion in healthy adults." European Journal of Applied Physiology, March 17, 2022. http://dx.doi.org/10.1007/s00421-022-04927-1.

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Abstract Purpose Stretching and foam rolling are common warm-up exercises and can acutely increase the range of motion (ROM) of a joint. However, possible differences in the magnitude of change on ROM between these two interventions on the immediate and prolonged effects (e.g., 10 min after the intervention) are not yet well understood. Thus, the purpose of this review was to compare the immediate and prolonged effects of a single bout of foam rolling with a single bout of stretching on ROM in healthy participants. Methods In total, 20 studies with overall 38 effect sizes were found to be elig

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Watanabe, Hideki, Kunio Nakagawa, and Masaaki Kakihana. "Abstract 1428: Effects of Continuous Positive Airway Pressure Treatment on Endothelial Function and Insulin Resistance in Patients with Obstructive Sleep Apnea and the Metabolic Syndrome." Circulation 116, suppl_16 (October 16, 2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_294.

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Background: Obstructive sleep apnea (OSA) and the metabolic syndrome are recognized as a risk factor for cardiovascular disease. Cardiovascular events have been reported to have a peak incidence in the early hours after waking in OSA patients. This study was designed to examine the influence of OSA on endothelial function in the early morning in patients with the metabolic syndrome. Methods: The severity of sleep-disordered breathing was evaluated by polysomnography in patients with the metabolic syndrome. Ten OSA patients (an apnea-hypopnea index [AHI] >30) with the metabolic syndrome was

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Okubo, Masashi, Cameron Dezfulian, Francis X. Guyette, Christian Martin-Gill, Sylvia Owusu-Ansah, and Clifton W. Callaway. "Abstract 126: Intravenous Versus Intraosseous Epinephrine Administration for Pediatric Patients with Out-of-hospital Cardiac Arrest." Circulation 142, Suppl_4 (November 17, 2020). http://dx.doi.org/10.1161/circ.142.suppl_4.126.

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Introduction: The 2015 American Heart Association Guidelines for Cardiopulmonary Resuscitation recommend intravenous (IV) or intraosseous (IO) epinephrine administration for pediatric patients with out-of-hospital cardiac arrest (OHCA). However, it is unknown whether the route of epinephrine administration affects patient outcomes. Our objective was to evaluate the association between the route of epinephrine administration and survival. Methods: We conducted a secondary analysis of the Resuscitation Outcomes Consortium Epistry, a prospective multicenter OHCA registry from 2011 through 2015 in

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