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1
Aminuddin, Wahidin Khaerul, Sumanta, Suklani, Nurul Rosidin Didin, and Sa'dudin Ihsan. "Character Education in the Perspective of Imam Asy-Sya'rani." International Journal of Social Science And Human Research 06, no. 02 (2023): 1285–92. https://doi.org/10.5281/zenodo.7680539.
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This research aims to examine Imam As-Sya'rani's perspective of the moral values contained in the book of Al Minah Al Saniyah. Imam As-Sya'rani's thoughts have their value in serving as a guide in inculcating moral education and character building. That becomes relevant when looking closely at the implementation of moral education, which only touches on cognitive aspects and has not yet touched on affective (inner) aspects. By touching the minds of students, moral education can shape human character with good morals. This type of research is qualitative with a literature review approach. The results of the study show that the book Al Minah Al Saniyah emphasizes the affective (inner) aspect of moral education, which includes morals to God, morals to fellow human beings, and morals to oneself. This thought can be used as a reference in instilling moral education and character education in order to form a complete human being in character.
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Jadidah, Fikrotul. "KASUS NENEK MINAH DITINJAU DARI PERSPEKTIF TEORI HUKUM POSITIVISME." IBLAM LAW REVIEW 2, no. 3 (2022): 129–42. http://dx.doi.org/10.52249/ilr.v2i3.98.
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Nenek Minah (55/petani), mengambil 3 biji buah kakao milik PT Rumpun Sari Antan (RSA), ketika sedang memanen kedelai di lahan garapannya. Perbuatan nenek Minah telah diketahui oleh Mandor perkebunan, dan pada saat itu juga nenek Minah telah mengembalikan biji kakao yang diambilnya dan meminta maaf. Namun pihak perusahaan tetap melaporkan kepada Polisi. Akhirnya dalam berkas perkara Nomor No. 247/PID.B/2009/PN.Pwt, nenek Minah harus menjalani persidangan di Pengadilan Negeri (PN) Purwokerto. Adanya perbenturan antara nilai-nilai keadilan pada kasus tersebut. Pertanyaan penelitian dalam kasus ini yaitu bagaimana hukum memandang kasus tersebut dalam perspektif kepastian hukum atau positivisme hukum dan prinsip kemanusiaan. Metode penelitian yang digunakan adalah yuridis normatif dengan spesifikasi penelitian deskriptif analitis. Dari hasil penelitian ini diperoleh kesimpulan yaitu Kasus hukum yang menjerat Nenek Minah ditelaah dengan menggunakan Paradigma Positivisme, ontologinya adalah sebuah realitas (hukum). Hukum yang dipaparkan adalah Pasal 362 KUHP. Hakim melakukannya dengan menghadirkan saksi-saksi dan adanya alat bukti yang dicocokkan dengan keterangan Nenek Minah sebagai terdakwa. Ketika semua unsur Pasal 362 terpenuhi, maka Nenek Minah diputus bersalah dan harus dihukum. Singkatnya, Paradigma Positivisme selalu menekankan objektivitas. Paradigma Positivisme yang memayungi aliran Legal Positivisme, menjelaskan tidak ada hukum di luar undang-undang, hukum identik dengan Undang-Undang. Bagaimana pun hukum harus ditegakkan yang keadilannya adalah keadilan menurut Undang-Undang. Hukum harus dipisahkan dari nilai kemanusiaan dan moral demi kepastian hukum. Itulah sebabnya Nenek Minah tetap harus dihukum terlepas dari seberapa besar kerugian yang diderita PT Rumpun Sari Antan, karena terbukti secara sah melakukan pencurian sebagaimana dirumuskan dalam Pasal 362 KUHP.
 Kata Kunci: Nenek Minah, Teori Hukum, Positivisme, Keadilan
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Hartanto, Hartanto, and Agus Santoso. "NETIZENS OPINIONS ON LAW ENFORCEMENT AND SOCIAL RESPONSIBILITY." Justisi: Jurnal Ilmu Hukum 9, no. 2 (2024): 16–33. http://dx.doi.org/10.36805/jjih.v9i2.5474.
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Netizens/netizens in Indonesia have a role in the disclosure of several legal cases. Therefore, this study aims to capture how the opinions and aspirations (Opinions) of netizens related to the positive law enforcement process in the criminal case of theft of cocoa beans charged to Grandma Minah (Case No. 247/Pid.B/2009/PN. PWT). The case of Grandma Minah is considered a case that disturbs the community's sense of justice. Netizens assessed that dragging Grandma Minah into the legal process just because of the theft of 3 cocoa grains was an irony and contrary to conscience. Netizens contrast the disparity between the firmness of law enforcement in the Grandma Minah case and the firmness of law enforcement in corruption cases or cases involving the rulers and the powerful. The spirit of Law 40/2007 on the Company directs the existence of corporate social responsibility (CSR) which can also be used as a benchmark to view this case. In this study, the opinions of netizens are classified as positive because they hope that the law can be more just, humane and conscientious. However, in the future, the potential for the opinions of netizens, which is sometimes also based on minimal data/facts, has the potential to distort the independence of judges.
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Iskarna, Tatang. "Redefining of the concept of a migrant housemaid in Ali's Minah Tetap Dipancung." Diksi 30, no. 1 (2022): 13–23. http://dx.doi.org/10.21831/diksi.v30i1.46683.
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This article explores diasporic problems faced by an Indonesian migrant housemaid working in Saudi Arabia, presented in Denny J. Ali's essay poem "Minah Tetap Dipancung" or "Minah is determined to be beheaded" (2012). This article uses diasporic literary criticism and poetry explication to reveal her tricky situation, struggle against oppression, and voice of hope concerning her profession. The analysis shows that Minah experiences disillusionment. She is oppressed, abused, and alienated because of the cultural barrier. However, Minah resists class and gender-based subjugation. Although she is helpless and determined to face the death sentence, she stands for her dignity. This poem also voices the need to redefine the concept of a migrant housemaid. Government and migrant worker stakeholders should set political will for improving the condition of migrant woman workers, especially legal protection, advocacy, and treatment as professional workers free from cultural bias in the destination country. A migrant housemaid is not merely an informal and private worker that the employer can treat as property arbitrarily. This poem advocates redefining her as a professional worker viewed from a broader cultural perspective, protected before the law, and provided with appropriate rights and advocacy. Keywords: migrant worker, diasporic problems, diasporic literary criticism, class-gender subjugation
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Alrodhan, Mohsen. "Serological Investigation Of Caprine Brucellosis At Saniyah District." Kufa Journal For Veterinary Medical Sciences 8, no. 1 (2017): 94–99. http://dx.doi.org/10.36326/kjvs/2017/v8i14314.
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Brucellosis is important zoonotic disease in Iraq affect variety species of animals, cattle, sheep goats, camels and horses and transmitted to human being by direct contact with diseased animals or by ingestion of contaminated unpasteurized milk and milk products .The disease characterized by chronic nature and the infection may develop unobserved which lead to local clustering of infected cases. Serological survey was conducted to detect prevalence of brucella antibodies among goats by random selection of 120 animals in two villages at Saniyah out of target population of 848 in 32 villages. Rose Bengal test used for detection of IgM antibodies by using standard Brucella antigen ( Synbiotics,Lyon, France ), indirect ELISA kit ( NovaLisa, Germany) was applied to investigate the seroprevalence of brucellosis in goats of studied area, the results of collected serum samples which subjected to RBT & i ELISA were 10.8 % and 12.5 % respectively,the positive results of i ELISA were higher than that of RBT which was significantly differed .The seropositivty in male 20% were higher than female 12.17% with significant difference , while the seroprevalence in relation to age groups were reported in adult animals only 14.4% and 16.6 by using RBT and ELISA respectively and there were no positive results in young ones .In conclusion brucellosis is still spread among goats and host risk factor comprise age and sex in addition to the types of serological test influence the seroprevalence percentage, more attention should be directed towards preventing of caprine brucellosis by application of proper control programs.
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Alrodhan, Mohsen. "Serological Investigation Of Caprine Brucellosis At Saniyah District." Kufa Journal For Veterinary Medical Sciences 8, no. 1 (2017): 94–99. http://dx.doi.org/10.36326/kjvs/2017/v8i14314.
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Brucellosis is important zoonotic disease in Iraq affect variety species of animals, cattle, sheep goats, camels and horses and transmitted to human being by direct contact with diseased animals or by ingestion of contaminated unpasteurized milk and milk products .The disease characterized by chronic nature and the infection may develop unobserved which lead to local clustering of infected cases. Serological survey was conducted to detect prevalence of brucella antibodies among goats by random selection of 120 animals in two villages at Saniyah out of target population of 848 in 32 villages. Rose Bengal test used for detection of IgM antibodies by using standard Brucella antigen ( Synbiotics,Lyon, France ), indirect ELISA kit ( NovaLisa, Germany) was applied to investigate the seroprevalence of brucellosis in goats of studied area, the results of collected serum samples which subjected to RBT & i ELISA were 10.8 % and 12.5 % respectively,the positive results of i ELISA were higher than that of RBT which was significantly differed .The seropositivty in male 20% were higher than female 12.17% with significant difference , while the seroprevalence in relation to age groups were reported in adult animals only 14.4% and 16.6 by using RBT and ELISA respectively and there were no positive results in young ones .In conclusion brucellosis is still spread among goats and host risk factor comprise age and sex in addition to the types of serological test influence the seroprevalence percentage, more attention should be directed towards preventing of caprine brucellosis by application of proper control programs.
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Dhani, Syntia Rahma, and Dilinar Adlin. "MODEL TGT BERBASIS KARTU SOAL DALAM PEMBELAJARAN TARI UNTUK MENINGKATKAN KEMAMPUAN BELAJAR SISWA SEKOLAH MENEGAH PERTAMA." Gesture: Jurnal Seni Tari 9, no. 2 (2020): 219. http://dx.doi.org/10.24114/senitari.v9i2.20447.
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ABSTRACT This study is behind the background by low learning ability of students in the process of dance learning Cek Minah Sayang, this marks the students below KKM average of 75, and so the way a teacher performs conventional learning is the method of speech alone. The purpose of this research is to describe the model of the learning Team Games Tournament question card on dance learning Cek Minah Sayang in an effort to improve the students’ learning ability at SMP Negeri 1 Rantau Utara. The method in this study utilizes quantitative precision using M. Fathurrohman’s model of study theory that contains model steps Team Games Tournament, the kind of research is Quasi Experimental Design a pretest-postest Group Design. The instrument of study used an objective test in the from of essay 10 problems the have already been tested for validation of item items. From our research, for the experiment class, the average pretest score is 46,67 and the average postest is 90. The average pretest control class is 34,67 and postest average is 67,34. Students learning skills are enhanced by modeling Team Games Tournament question card is 80% whereas students’ learning skills are taught without using models Team Games Tournament cards based on 47%. Data obtained through test analysis t is tcount> ttable (3,580> 1,694) HO rejected and Ha accepted is that there is a difference in the results of a students’ learing ability after establishing a model of learning Team Games Tournament question card about students SMP. Keywords: A model of learning Team Games Tournament, question card, ability of learning, Cek Minah Sayang. ABSTRAK Penelitian ini dilatarbelakangi oleh rendahnya kemampuan belajar siswa dalam proses pembelajaran tari Cek Minah Sayang, hal ini ditandai dengan nilai rata-rata siswa dibawah KKM yaitu 75, demikian pula cara guru melaksanakan pembelajaran yang masih bersifat konvensional yaitu metode ceramah saja. Tujuan penelitian ini adalah untuk mendeskripsikan model pembelajaran Team Games Tournament Berbasis Kartu Soal pada pembelajaran tari Cek Minah Sayang dalam upaya meningkatkan kemampuan belajar siswa di SMP Negeri 1 Rantau Utara. Metode dalam penelitian ini menggunakan metode penelitian kuantitatif dengan menggunakan teori model pembelajaran M. Fathurrohman yang mengandung langkah-langkah model Team Games Tournament, jenis penelitiannya adalah Quasi Experimental Design yaitu Pretest-Posttest Group Design. Instrumen penelitian yang digunakan adalah tes objektif dalam bentuk essay berjumlah 10 soal yang sudah diuji validasi butir item. Dari hasil penelitian, untuk kelas eksperimen diproleh nilai rata-rata pretest sebesar 46,67 dan nilai rata-rata posttes sebesar 90. Sedangkan nilai rata-rata pretest kelas kontrol sebesar 34,67 dan nilai rata-rata posttest sebesar 67,34. Peningkatan kemampuan belajar siswa yang diberikan pembelajaran dengan model Team Games Tournament Berbasis Kartu Soal yaitu 80% sedangkan kemampuan belajar siswa yang diajarkan tanpa menggunakan model Team Games Tournament Berbasis Kartu Soal yaitu 47%. Data yang diperoleh dengan analisis uji t yaitu thitung > ttabel (3,580 > 1,694) Ho ditolak dan Ha diterima yaitu ada perbedaan hasil kemampuan belajar siswa setelah diterapkannya model pembelajaran Team Games Tournament Berbasis Kartu Soal pada siswa SMP. Kata kunci : Model Pembelajaran Team Games Tournament, Kartu Soal, Kemampuan Belajar, Cek Minah Sayang.
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Arif, Muhamad, Yuldashev Azim Abdurakhmonovich, and Sulaiman Dorloh. "Character Education in the 21st Century: The Relevance of Abdul Wahhab Ash Syarani’s and Thomas Lickona’s Concepts." Islamic Review: Jurnal Riset dan Kajian Keislaman 12, no. 1 (2023): 35–58. http://dx.doi.org/10.35878/islamicreview.v12i1.690.
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This article addresses the development of education and technology in the 21st century society. In order for education to function efficiently, the need of moral/character education is a necessary step in preserving its survival. In this study, the researcher was interested in Ash Syarani's theory of moral education because of its relation to the findings of Thomas Lickona's theory (moral knowing, moral feeling, and moral action) in education in the twenty-first century. This study utilized a literature review approach. Ash Syarani's Minahus Saniyah and Lickona's Teaching for Character: How Schools Can Teach Respect and Responsibility are the key data sources. While content analysis from Elo and Marsh was employed for data analysis in this study, The notion presented in Shaykh Abdul Wahhab Ash Syarani's book Minahus Saniyah is more applicable to Indonesian culture, particularly in studies that provide more real-world examples and are not confined to concepts (such as character education from Thomas Lickona's theory). The repercussions are fairly real that this analysis addresses the concept of moral education that is still relevant (in Thomas Lickona's theory; moral knowing, moral feeling, and moral action) for implementation in Indonesian education in the twenty-first century.
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Syahriati, Syahriati. "KAJIAN PERUBAHAN DESAIN KEMASAN PADA PRODUK BUMBU TRADISIONAL MAKASSAR." JURNAL GALUNG TROPIKA 4, no. 3 (2015): 179–84. http://dx.doi.org/10.31850/jgt.v4i3.291.
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Tujuan dari penelitian ini adalah untuk (1) meninjau mekanisme perusahaan melakukan perubahan desain produk, (2) untuk melihat promosi dilakukan perusahaan pada saat perubahan produk pengepakan desain, dan (3) untuk mengidentifikasi perubahan volume penjualan sebelum dan setelah produk pengepakan desain dilakukan. Kajian ini dilakukan di UD. AL-MINAH yang terletak di Kecamatan Bajeng, Kabupaten Gowa, Sulawesi Selatan. Studi ini menggunakan pendekatan kualitatif, sehingga digunakan data deskriptif untuk menjelaskan temuan studi. Pengumpulan data dilakukan melalui wawancara untuk menghasilkan data primer dan pengamatan untuk menghasilkan data sekunder. Hasil penelitian menunjukkan bahwa selama periode tiga perubahan produk pengepakan desain (plastik polyetilen, plastik polypropilen dalam bentuk pot, dan kemasan fleksibel stand-up pouch) menyebabkan peningkatan volume penjualan produk berbagai bumbu dari UD AL-MINAH. Setiap periode perubahan desain pengemasan, perusahaan mempertimbangkan pilihan kemasan jenis melalui survei pasar, produk menunjukkan, diskusi tentang penelitian dan pengembangan dengan packing firma konsultasi desain produk. Perusahaan melakukan promosi produk melalui produk, persaingan dan iklan di media massa.
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Maskur, Muhammad Azil. "Potret Buram Positivisme Hukum: Sebuah Telaah Terhadap Kasus-Kasus Kecil yang Menciderai Rasa Keadilan Masyarakat." Hukum dan Masyarakat Madani 6, no. 1 (2016): 41. http://dx.doi.org/10.26623/humani.v6i1.853.
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<p><em>The Founding Fathers</em> pada awal kemerdekaan telah menyepakati bentuk negara yaitu negara yang berdasarkan pada hukum <em>(rechstaat)</em>. Hal tersebut ditegaskan kembali dalam Undang-Undang Dasar 1945 Amandemen Pasal 1 ayat (3) yang menyatakan bahwa negara Indonesia adalah negara hukum. Hukum disini adalah hukum yang berdasarkan Pancasila, dimana hukum tidak dimaknai sebagai ilmu positivistik belaka akan tetapi lebih pada ilmu tentang kemasyarakatan. Akan tetapi nampaknya pemahaman holistik terhadap hukum dewasa ini sudah keluar dari jalur cita-cita pendirian bangsa ini. Banyaknya kasus yang menciderai rasa keadilan masyarakat seperti kasus minah, kasus manise dan kasus prita yang menyita perhatian publik beberapa waktu yang lalu menjadi potret buram penegakan hukum yang positivistik legalistik. Positivisme hukum seakan menggelinding liar ketengah-tengah pemahaman para aparat penegak hukum yang menciderai rasa keadilan masyarakat. Hukum bukanlah suatu hal yang mati akan tetapi hukum selalu bergerak dinamis dan mengikuti perkembangan zaman. Kasus-kasus kecil seperti kasus minah, manise dan prita adalah contoh kecil dari liarnya penegakan hukum berparadigma positivistik legalistik tanpa ada yang bisa mengendalikan bahkan pemikiran positivistik legalistik ini telah mengakar pada hakim sebagai aparat pemutus pada peradilan. Secara hukum positif, polisi, jaksa, dan hakim tidak dapat dipersalahkan karena hanya memenuhi rumusan Undang-Undang yang tidak memberikan kesempatan pada aparat penegak hukum untuk berbuat sesuai nurani. Walaupun hakim diberi kebebasan sesuai hati nurani akan tetapi apabila terbentur dengan bukti yang sudah lengkap, tidak alas an bagi hakim untuk memutuskan. Disisi lain masyarakat sebagai obyek hukum merasa terusik rasa keadilannya dengan keputusan hakim yang menyatakan minah dan prita bersalah. Sehingga perlu dilakukan upaya penegakan hukum progresif dan dibarengi dengan pembenahan sistem hukum pidana baik dalam segi substansi, struktur maupun budaya hukum.</p>
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Dewi, Padma, and Budiwirman Budiwirman. "Analysis of the Symbolic Meaning and Cultural Identity in Sarolangun Batik Arts Jambi Province." International Journal of Educational Dynamics 2, no. 2 (2020): 10–18. http://dx.doi.org/10.24036/ijeds.v2i2.266.
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The purpose of this study is to analyze the symbolic meaning and cultural identity of batik. The symbolic meaning of a form of batik motifs gives signs to represent the cultural character of Sarolangun District. Cultural identity acts as a mediation of interaction by the Sarolangun district community to be known in the outside the world. This research method uses descriptive qualitative method. The approach taken is semiotics by Charles Piers.The results of the Semiotics Peirce concept can distinguish the meaning of batik based on the shape of the batik motif and the sign found in the decoration. The symbolic meaning of a number of batik motifs are found in the theme of Mato Punai, Cik Minah edge motif, quaint bird. Mato Punai is a bird's eye motif as a symbol of prosperity. Cik Minah edge motif symbolizes the agility of a woman in life. There are 18 batik motifs that have been recognized and has been patents, hereby that Sarolangun batik arts has its own identity for Saroalngun district culture.
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Hanafi Urwatil Usqo, Faisar Ananda Arfa, and Nurasiah. "Kasus Nenek Minah Tinjauan Filsafat Hukum Islam dan Barat." Arus Jurnal Sosial dan Humaniora 4, no. 3 (2024): 2199–206. https://doi.org/10.57250/ajsh.v4i3.885.
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Kasus Nenek Minah, seorang lansia yang dihukum karena mencuri tiga buah kakao, menimbulkan kontroversi terkait penerapan hukum yang dianggap tidak proporsional dengan nilai barang yang dicuri dan kondisi sosial-ekonomi pelaku. Penelitian ini bertujuan untuk menganalisis kasus tersebut dari perspektif filsafat hukum Islam dan Barat guna memahami penerapan prinsip keadilan dan kemanusiaan. Metodologi yang digunakan adalah penelitian hukum normatif dengan pendekatan filsafat hukum Islam dan Barat. Sumber data meliputi literatur hukum Islam (hudud, ta'zir, dan Maqasid Syariah) serta teori-teori hukum Barat seperti utilitarianisme, teori keadilan, dan realisme hukum. Hasil analisis menunjukkan bahwa dalam perspektif hukum Islam, hukuman hudud tidak berlaku karena syarat-syarat seperti nilai barang yang kecil dan keadaan darurat tidak terpenuhi. Prinsip ta'zir dan Maqasid Syariah lebih relevan diterapkan, dengan penekanan pada solusi yang bersifat edukatif dan mendidik. Dari perspektif hukum Barat, teori keadilan John Rawls dan utilitarianisme Jeremy Bentham menggarisbawahi pentingnya hukuman yang proporsional dan mempertimbangkan manfaat sosial, terutama bagi kelompok rentan seperti Nenek Minah. Kesimpulannya, pendekatan hukum yang humanis dan berbasis keadilan restoratif lebih sesuai diterapkan pada kasus ini. Rekomendasi penelitian adalah perlunya pembaruan hukum pidana di Indonesia yang lebih adaptif terhadap kondisi sosial-ekonomi pelaku.
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YAPRIZAL, Andi, Ebith THEOPILUS, and Mutia Evi KRISTHY. "The Matter of Grandma Minah in the Perspective of Positivism." Journal of Political And Legal Sovereignty 1, no. 4 (2024): 142–47. https://doi.org/10.38142/jpls.v1i4.142.
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Purpose: In a law there are various parties who will enforce the laws in force in Indonesia. These parties carry out law enforcement so as not to create a violation of the law, bring order to society and regulate society in accordance with the norms and rules that apply in a country is not easy to apply in public life.Methodology:The resolution of a case of violation of the law is a legal process. Legal process is an action to resolve cases of violations of the law to achieve a settlement in accordance with applicable regulations in Indonesia.Findings: In legal cases that have occurred in Indonesia, the provision of criminal sanctions against Grandma Minah who is a cocoa thief has received a lot of attention from the public. The case of "Grandma Minah" is an example of law enforcement in Indonesia that is still considered by the public to have not realized sanctions in rulings in accordance with conscience and moral considerations.Implication:The reason that often arises is the injustice of sanctions against theft crimes that can actually still be resolved by familial means. But this is the reality that occurs on the ground between legal theory and practice that has different implementations.
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YAPRIZAL, Andi, Ebith THEOPILUS, and Mutia Evi KRISTHY. "The Matter of Grandma Minah in the Perspective of Positivism." Journal of Political And Legal Sovereignty 1, no. 2 (2023): 142–47. http://dx.doi.org/10.38142/jpls.v1i2.142.
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Purpose: In a law there are various parties who will enforce the laws in force in Indonesia. These parties carry out law enforcement so as not to create a violation of the law, bring order to society and regulate society in accordance with the norms and rules that apply in a country is not easy to apply in public life.Methodology:The resolution of a case of violation of the law is a legal process. Legal process is an action to resolve cases of violations of the law to achieve a settlement in accordance with applicable regulations in Indonesia.Findings: In legal cases that have occurred in Indonesia, the provision of criminal sanctions against Grandma Minah who is a cocoa thief has received a lot of attention from the public. The case of "Grandma Minah" is an example of law enforcement in Indonesia that is still considered by the public to have not realized sanctions in rulings in accordance with conscience and moral considerations.Implication:The reason that often arises is the injustice of sanctions against theft crimes that can actually still be resolved by familial means. But this is the reality that occurs on the ground between legal theory and practice that has different implementations.
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Zeglache, Hamza. "The Concept of the Centre in Islam." ICR Journal 2, no. 4 (2011): 609–20. http://dx.doi.org/10.52282/icr.v2i4.601.
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This article argues that any exploration of the textual representations of place, space, and landscape in the pre-modern Arabic-Islamic tradition requires grasping the cultural conception of the centre reflecting developments from a long historical and textual tradition of cosmological ideas found in the work of Yaqut’s (d. 1229) Mujam al-buldan, and al-Suyuti’s (d. 1505) al-Hayat al-saniyah fil-hayat al-sunniyah. It further explores the complex construct of the centre in Islam within the context of its relation to the origin of Islamic cities by considering it an organising principle of the mental and moral disposition for spiritual and physical orientation.
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Mahmudah, Himmatul. "Furas at-Tafa’ul ‘Inda Ta’allumi al-Lughah as-Saniyah fi Qo’ati ad-Dars." LISANUDHAD 4, no. 2 (2017): 33. http://dx.doi.org/10.21111/lisanudhad.v4i2.1605.
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Kadhim, Melak Salim, and Lujain Ibrahim Hussain. "Study Plant Contamination Surrounding the Brick Factory in Al- Saniyah: Al- Diwaniyah Governorate, Iraq." Global Academic Journal of Agriculture and Biosciences 6, no. 04 (2024): 85–89. http://dx.doi.org/10.36348/gajab.2024.v06i04.001.
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This study examined how brick factories in Al-Saniyah, Al-Diwaniyah Governorate, affected the surrounding plants at 50, 500, and 1000-meter intervals in relation to the direction of the prevailing winds, as well as at 50, 500, and 1000-meter intervals in the opposite direction. Zinc concentrations were measured; the values ranged from 20.2 µg\g in the summer to 161.3 µg\g in the winter. Additionally, in winter, the content of cadmium was 0.39 at its lowest and 3.7µg\g at its maximum. The maximum concentration of cobalt was 41.55 µg/g in winter, while the lowest was 2.55 µg/g in summer. While the highest value in Pb was 96.4 µg/g in S2 in winter and the lowest value was 0.7 µg/g in S6. It's possible that the causes Seasonal variations in wind and precipitation that leave suspended metals in the atmosphere may be the cause of wintertime increases in element concentrations. Alternatively, better weather could be the reason for a rise in productivity.
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Ackerman, Susan E. "Dakwah and Minah Karan; Class formation and ideological conflict in Malay society." Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia 147, no. 2 (1991): 193–215. http://dx.doi.org/10.1163/22134379-90003186.
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Friyadi, Arif. "COUNTER NARRATIVES FROM HADITH TEXTS OF KH. SYA’RONI AHMADI’S AL-FARAID AL-SANIYYA AGAINST WAHHABISM." Riwayah : Jurnal Studi Hadis 9, no. 1 (2023): 27. http://dx.doi.org/10.21043/riwayah.v9i1.12427.
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<p>The discourse of Ahlus Sunnah wa al-Jama'ah Islam is a topic that will not be obsolete throughout the history of Muslims. The emergence of the Salafi Wahabi sect of Islam in various Muslim countries has caused the division of Muslims. Rahmatal lil 'alamin Islam seems to be eroded by the takfiri and bid'I movements of various figures. Some of the world's scholars through their works have made a major contribution to stem this movement. Among these works is the book al-Faraid al-Saniyah by KH. Sya'roni Ahmadi, which contains the concept of countering wahabi salafi, especially in Indonesia. This research uses a qualitative-based character study which basically relies on data from interviews, supporting literature and biographies of the figures studied. The results of this study found that the purification of religion heralded by Wahabi figures by referring to the Qur'an and hadith is actually not feasible to be applied in Indonesia. A wrong understanding in the interpretation of the Qur'an and hadith will plunge a person into national disintegration. Therefore, the ahlussunah wal jama'ah creed must be upheld so that an Indonesian Muslim becomes a moderate Muslim who accepts various ikhtilaf.</p><p>[Wacana Islam Ahlus Sunnah wa al-Jama’ah merupakan topik yang tidak akan ketinggalan zaman sepanjang sejarah umat Islam. Munculnya sekte Islam Salafi Wahabi di berbagai negara Muslim telah menyebabkan perpecahan umat Islam. Rahmatal lil ‘alamin Islam seakan tergerus oleh gerakan takfiri dan bid’I dari berbagai tokoh. Beberapa cendekiawan dunia melalui karya-karyanya telah memberikan kontribusi besar untuk membendung gerakan ini. Diantara karya tersebut adalah kitab al-Faraid al-Saniyah karya KH. Sya’roni Ahmadi yang berisi tentang konsep countering wahabi salafi khususnya di Indonesia. Penelitian ini menggunakan studi karakter berbasis kualitatif yang pada dasarnya mengandalkan data dari hasil wawancara, literatur pendukung dan biografi tokoh yang diteliti. Hasil penelitian ini menemukan bahwa pemurnian agama yang digembar-gemborkan oleh tokoh-tokoh Wahabi dengan berpedoman pada al-Qur’an dan hadits sebenarnya tidak layak diterapkan di Indonesia. Pemahaman yang salah dalam menafsirkan al-Qur’an dan hadis akan menjerumuskan seseorang ke dalam disintegrasi bangsa. Oleh karena itu, akidah ahlussunnah wal jama’ah harus ditegakkan agar seorang muslim Indonesia menjadi muslim moderat yang menerima berbagai ikhtilaf.]</p>
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Wibawa, Iskandar. "IMPLEMENTASI ASAS KEPASTIAN HUKUM YANG BERKEADILAN BERDASAR CITA HUKUM BANGSA INDONESIA (Kajian Putusan Pengadilan Negeri Banyumas tentang kasus mbah Minah)." YUDISIA : Jurnal Pemikiran Hukum dan Hukum Islam 8, no. 1 (2018): 18. http://dx.doi.org/10.21043/yudisia.v8i1.3221.
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<em>Legality is one basic of penal law beside culpability in deciding the punishment. Legality is often perceived similar to law enforcement. According to Article 1 (1) of the Penal Law (KUHP), the law refers to written law. In fact, there is also living law mentioned in the Constitution. This kind of situation often causes the judge decision fails to meet social justice since the decision is merely based on formal law and neglected material law, such as in the case of Minah in Banyumas Court. Thus, progressive approach is necessitated in order to understand legality both in formal and material law in accordance with national legal ideals, Pancasila.</em>
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Aisyi, Nadia Rohadatul, and FX Joko Priyono. "Positivism and the Separation of Law and Morals." International Journal of Research and Innovation in Social Science VII, no. XI (2023): 1240–50. http://dx.doi.org/10.47772/ijriss.2023.7011096.
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Legal positivism makes a strict separation between law and morality. The originators of legal positivism separated the legal domain from the moral domain. The purpose of this paper is to explore how law and morality are separated in the positivism paradigm. This research is a normative type of research with a conceptual approach. Legal positivism or positive law strictly separates law and morals, as well as between the law that applies and the law that should be. There is no room for considerations that refer to other normative sources. The case involving Grandma Minah is one example of the application of the view that the law is considered normative and does not consider the moral elements contained therein.
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Rahim, Muhammad Nur, Nova Vatmawati, Cindy Irmadani, and Enos Paselle. "Kasus Sengketa Tata Usaha Negara Dengan Objek Putusan Nomor 9/G/2023/PTUN.SMD., Kecamatan Balikpapan Selatan." Binamulia Hukum 13, no. 1 (2024): 35–43. http://dx.doi.org/10.37893/jbh.v13i1.671.
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Penelitian ini mengeksplorasi konflik terkait kepemilikan sertifikat hak guna bangunan di Sepinggan Baru, Balikpapan Selatan. Tujuan utama adalah untuk menangani perselisihan administrasi antara individu atau entitas hukum dengan badan atau pejabat administrasi negara. Pertanyaan kunci dalam studi ini adalah apakah ada cacat hukum dalam prosedur dan substansi penerbitan objek sengketa oleh tergugat. Pendekatan penelitian yang digunakan adalah pendekatan hukum normatif dengan metode pendekatan undang-undang dan pendekatan kasus. Temuan menunjukkan bahwa Pengadilan Tata Usaha Negara (PTUN) memiliki otoritas mutlak dalam menyelesaikan perselisihan administrasi negara, termasuk konflik kepemilikan sertifikat hak guna bangunan. Kesimpulan dari studi ini adalah bahwa sertifikat hak guna bangunan atas nama Saniyah dinyatakan tidak sah dan dibatalkan, dan tergugat harus mengembalikan sertifikat tersebut kepada penggugat. Studi ini penting karena dapat dijadikan referensi oleh pembuat kebijakan dan masyarakat dalam menyelesaikan perselisihan administrasi negara yang berkaitan dengan kepemilikan tanah dan sertifikat hak guna bangunan.
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Abidin, Mukhlis. "METODOLOGI PEMAHAMAN SYARI’AH (Analisis Muqaddimah Kitab al-Muwafaqat Karya Asy-Syatibi)." YUDISIA : Jurnal Pemikiran Hukum dan Hukum Islam 8, no. 2 (2018): 299. http://dx.doi.org/10.21043/yudisia.v8i2.3241.
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<p><em>Legality is one basic of penal law beside culpability in deciding the punishment. Legality is often perceived similar to law enforcement. According to Article 1 (1) of the Penal Law (KUHP), the law refers to written law. In fact, there is also living law mentioned in the Constitution. This kind of situation often causes the judge decision fails to meet social justice since the decision is merely based on formal law and neglected material law, such as in the case of Minah in Banyumas Court. Thus, progressive approach is necessitated in order to understand legality both in formal and material law in accordance with national legal ideals, Pancasila. </em></p>
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Murdoko, Murdoko. "DISPARITAS PENEGAKAN HUKUM DI INDONESIA (ANALISIS KRITIS KASUS NENEK MINAH DALAM PERSPEKTIF HUKUM PROGRESIF)." Perspektif Hukum 16, no. 2 (2017): 221. http://dx.doi.org/10.30649/phj.v16i2.66.
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<em>This paper examines the law enforcement in public domain. The court decisions on many cases often undergo disparities that deny the sense of justice. The disparities increasingly appear when the case comes to people who have political or economic power. However, when the case comes to the poor, who do not have power and so on, the law can be very sharp to enforce. In perspective of the progressive law, the case of </em>Nenek Minah is<em> ideally not relevant to prosecute at the court. In fact, that case shows that the working of the law in Indonesia is still based on the text rather than the context. The law enforcement is solely based on the written provisions (legalistic-positivistic) without paying attention to sociological dimension, so that the law enforcement is still far away from the purpose of law that is able to present the real justice.</em>
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Sinlae, Ester Stevany Putri, Rizki Dwi Putra, and Asmak Ul Hosnah. "PERLINDUNGAN HUKUM TERHADAP TINDAK PIDANA TERTENTU DALAM KUHP : TINJAUAN KASUS NENEK MINAH DAN KAKAO." JUSTITIA Jurnal Ilmu Hukum dan Humaniora 7, no. 2 (2024): 279. http://dx.doi.org/10.31604/justitia.v7i2.279-288.
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Bu'ulolo, Efori, and Eko Firdonal Simamora. "Implementasi Metode Hybrid Rooc-Moora-SPK-Penentuan Kenaikan Gaji Karyawan PT. Ronal Jasa Mandiri." Explorer 3, no. 1 (2023): 1–6. https://doi.org/10.47065/explorer.v3i1.407.
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Hal yang perlu diperhatikan oleh seorang pimpinan dengan mimikirkan untuk keberlanjutan kemajuan perusahaan diperlukan adanya kerjasama dengan tim, bentuknya adalah mengetahui keadaan karyawan dalam hal ini adalah gaji. Gaji sangat bersifat penting untuk dipikirkan. Pada PT.Ronal Jasa Mandiri untuk kenaikan gaji karyawan menggunakan prosedur yang sudah ditetapakan tapi belum memadai untuk diterapkan keseluruhannya. Oleh karena itu dalam pengambilan keputusan belum memiliki standar dan dan aturan maupun kriteria pada penilaian karyawan. Pada penelitian ini peneliti memabantu memberikan solusi kepada perusahaan dengan beberapa perhitungan dengan Metode MOORA, Kriteria yang digunakan pada penelitian ini kedisipinan, kualitas pekerjaan, produktivitas, tanggung Jawab, penggunaan fasilitas dan sparepart,loyalitas,attitude, moral dan mental, pengembangan diri. Dari hasil Perhitungan sistem pendukung keputusan kenaikan gaji karyawan memberikan keputusan terbaik dari sejumlah alternatif, dimana alternatif terbaik alternatif y4 atas nama “Agus dengan nilai 0,162589121, y11 atas nama minah dengan nilai 0,156364706.
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Friyadi, Arif. "Counter-Narrative of Shi'ism in The Hadith Text of Kitab “Al-Faraid Al-Saniyah” KH. Sya'roni Ahmadi Kudus." International Journal Ihya' 'Ulum al-Din 25, no. 1 (2023): 1–12. http://dx.doi.org/10.21580/ihya.25.1.14603.
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The beginning of the emergence of Shi'ism initiated by a Jew, Abdullah bin Saba' had made considerable conflict among the companions at that time. The friction tapered when the killing of Ali bin Abi Talib and his son Husain in Karbala'. From year to year, the emergence of Shi'ism in several Middle Eastern countries led to the country's disintegration. The conflict of Imamiyah that leads to bloodshed seems to have no end at all times. Of course, this should not happen in Indonesia, which is known as a plural country. Of this problem, some scholars are called to write a book to counter Shi'aism in Indonesia. One is KH Sya'roni Ahmadi, with the text 'al-Faraid al-Saniyah.' This paper aims to explore KH. Sya'roni Ahmadi's thoughts on preventing the development of the Shi'a sect in Indonesia. This paper is categorized as qualitative research by comparing literature and interviews with the family of the book's author directly. The results showed that KH Sya'roni's role in increasing the existence of Aswaja in Indonesia needs to be appreciated. This is a form of his vocation to protect the country from disintegration and sect divisions.
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Milla Hariani, M Iqbal Rizqullah, and Nur Aini Dian Novita. "Pelatihan Foto Produk UMKM Teh Poci Bu Minah untuk Meningkatkan Daya Tarik Konsumen di Desa Wadungasih Sidoarjo." NUSANTARA Jurnal Pengabdian Kepada Masyarakat 5, no. 2 (2025): 300–309. https://doi.org/10.55606/nusantara.v5i2.4875.
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Product photography training is one of the important strategies in increasing consumer appeal to MSME products. This activity was carried out with the aim of helping MSME Teh Poci Bu Minah in Wadungasih Village, Sidoarjo, in developing the visual quality of its products to be more attractive and competitive in the digital market. The methods used in the training include an introduction to the basics of product photography, lighting techniques, product arrangement, and the use of simple tools such as cellphone cameras. The results of the training showed a significant increase in participants' ability to produce more professional and attractive product photos. In addition, there was an increase in consumer interest based on engagement data on social media and an increase in sales after the publication of photos that had been improved in quality. This activity is expected to be an example of MSME empowerment through increasing digital and visual literacy.
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AL-BAYATI, A. S. "CHARACTERIZATION OF GREEN ONION WITH NPK FERTILIZATION AND FOLIAR APPLICATION OF HORNWORT EXTRACT." SABRAO Journal of Breeding and Genetics 55, no. 6 (2023): 2140–48. http://dx.doi.org/10.54910/sabrao2023.55.6.25.
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A field trial on green onion crops in the autumn of 2020 transpired at a private farm in the District Al- Saniyah, Al-Diwaniyah Governorate, Iraq. The presented study aimed at characterizing green onion (Allium cepa L.) plants with NPK fertilization and foliar application of hornwort extract for growth and yield traits. In this experiment, the first factor comprised three NPK levels (0, 50%, and 100%) of NPK (150:100:150 kg ha-1) recommended fertilizer added to the soil, while the second factor included the foliar application of hornwort extract with two different concentrations (0, 20 ml L-1). The experiment in a randomized complete block design (RCBD) with factorial arrangement had three replications. Consequently, the recommended dose of NPK (100%) and spraying hornwort extract at 20 ml L-1 revealed a significant increase in the studied traits, i.e., plant height, length of the longest tubular leaf, number of leaves, fresh weight of tubular leaves, number of bulbs per plant, weight of the bulb, the diameter of the bulb, leaf chlorophyll content, bulb carbohydrate content, leaf carotenoid content, and plant yield. The interactions of both factors also showed a favorable effect on the mentioned traits in green onion.
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Sulistyawan, Aditya Yuli. "EPISTEMOLOGI HUKUM (YANG) SUBJEKTIF SEBAGAI JALAN MEWUJUDKAN HUKUM YANG BERPERI-KEMANUSIAAN." Jurnal Hukum Progresif 7, no. 1 (2019): 98. http://dx.doi.org/10.14710/hp.7.1.98-107.
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Penegakan hukum yang dipengaruhi oleh dominasi paradigma positivisme memaparkan potret penegakan hukum yang tidak berperi-kemanusiaan karena dianggap tidak mengedepankan keadilan, khususnya bagi rakyat kecil. Kasus-kasus hukum seperti pencurian tiga biji kakao oleh Nenek Minah di Banyumas, pencurian setandan pisang oleh Mbah Klijo di Yogyakarta hingga kasus Baiq Nuril yang oleh Putusan MA divonis bersalah melanggar UU ITE. Sepertinya hukum memang tidak didesain untuk memanusiakan manusia. Penegak hukum seperti hanya menjalankan tugasnya untuk merealisasikan teks-teks semata, sekaligus di saat yang sama mengabaikan konteksnya. Ciri demikian sejatinya adalah hakikat hukum yang ber-ontologi realisme naif sebagaimana diyakini oleh pemeluk paradigma positivisme dalam memaknai realitas. Melihat kenyataan paradigmatik yang ada, sejatinya hukum yang ber-epistemologi subjektif adalah sebuah tawaran untuk mewujudkan hukum yang berperikemanusiaan. Apa dan bagaimanakah paradigma yang memberi kemungkinan mewujudkan itu adalah permasalahan yang akan dibahas dalam tulisan ini. Melalui tradisi kualitatif dan paradigma yang menuntun penulis, pembahasan atas permasalahan ini menghadirkan jawaban pada pilihan dua paradigma yang berepistemologi subjektif, yakni: Critical Theory et. al. atau Konstruktivisme. Lantas, perlukah kemudian terjadi shifting paradigm sebagai solusi (?).
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Sulistyawan, Aditya Yuli. "Time for Punishment with Subjectivity: Study Philosophy of Law." Walisongo Law Review (Walrev) 1, no. 1 (2019): 17. http://dx.doi.org/10.21580/walrev.2019.1.1.4754.
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<p class="IABSSS">The dominance of legal positivism in thought and law enforcement is a reality. Saintism of legal science presents a law that is conceptualized as something that exists in sensory terms, along with its straightforward, rational, and objective nature. Law is always requested objectively. Objectivity is done by freeing the subject's mind to the legal reality that already exists as an object. Therefore, various legal cases such as the case of Asyani, Rasminah, Minah and others, are things that are easily proven as violating the law because it is a violation of the text of the article of law. Such a way of law, is now starting to become a public concern. So, when objectivity begins to be questioned, that's when the real subjectivity of asking begins to be considered - and this will be explained [only] in the study of legal philosophy, especially paradigmatic studies. This paper will discuss the possibility of subjectivity in law, which will be presented in the paradigmatic study.</p>
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Dina, Salma. "The Implementasi Regulasi Pemidanaan Terhadap Tindak Pidana Ringan Perspektif Restoratif Justice dan Tafsir QS. Al-Maidah: 33-34." As-Shahifah : Journal of Constitutional Law and Governance 4, no. 2 (2024): 193–208. https://doi.org/10.19105/asshahifah.v4i2.17277.
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On August 2, 2009, in Darmakradenan Village, Ajibarang District, Banyumas, Central Java, Grandma Minah who was farming on her land which was also used as a cocoa plantation by PT RSA, took some cocoa fruits without permission. Grandma Minah's actions were later discovered by a plantation foreman who was on patrol. This research method uses a normative legal research method using the Case Approach which examines cases that occur in society and then examines them from the perspective of laws and regulations. The results of the study showed that there were weaknesses in the regulation of criminal penalties for minor crimes, as well as handling criminal acts using the conventional justice system or restorative justice in Grandma Minah's case and there was a view of Munir's Interpretation of QS Surat Al-Maidah verses 33 & 34 regarding criminal cases that Allah SWT allows them to turn it around before being arrested. However, if the repentance is sincere because of Allah SWT, not just a trick to avoid punishment, then the punishment is dropped.
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Samosir, Lidia Karuniamay, and Muji Gunarto. "Pemanfaatan Digital Marketing Dalam Meningkatkan Penjualan Pelaku Usaha." Jurnal Nasional Pengabdian Masyarakat 6, no. 1 (2025): 34–53. https://doi.org/10.47747/jnpm.v6i1.2532.
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This study aims to analyze the utilization of digital marketing in increasing sales at the micro, small, and medium enterprise (UMKM) Pempek Minah Tanggo Rajo Cindo, located in 7 Ulu, Palembang City. The research employs a field research method with a descriptive qualitative approach. Data was collected through interviews with the business owner, Mrs. Aminah, and customers who use online communication media such as WhatsApp, Facebook, and Instagram. Additionally, direct observation was conducted to understand the implementation of digital marketing in the business. Data collection techniques included interviews, observation, and documentation. The results of the study show that the use of digital marketing through social media platforms like Instagram and WhatsApp has a positive impact on increasing sales. This includes providing transparent product information, ease of product updates, and product comparative analysis. Furthermore, the digital marketing techniques applied include advertising, direct marketing, personal selling, and sales promotion, which enhance customer response and drive sales. This research highlights how digital marketing can play a crucial role in the development of UMKM businesses through more effective and efficient marketing strategies.
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Yusoff, M. Jismani, and Nor Hafizi Yusof. "ANALISIS PERBANDINGAN KAEDAH JAM‘ AL-QIRA’AT DALAM KARYA AL-TUHFAT AL-MARDIYYAH DAN AL-MINAH AL-ILAHIYYAH BERDASARKAN QIRA’AT AL-SAB‘ TARIQ AL-SHATIBIYYAH." Malaysian Journal Of Islamic Studies (MJIS) 8, no. 1 (2024): 57–67. https://doi.org/10.37231/mjis.2024.8.1.251.
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Jam‘ al-Qira’at merupakan salah satu kaedah menghimpunkan bacaan Qira’at yang dicipta bagi mempraktikkan wujuh al-Qira’at dalam pembacaan al-Qur’an. Kaedah Jam‘ al-Qira’at merupakan satu langkah yang wajar bertujuan memelihara dan mengekalkan wujuh al-Qira’at dalam al-Qur’an sebagaimana ia diturunkan. Oleh itu, kajian ini dilakukan bertujuan menganalisis dan membandingkan kaedah Jam’ al-Qira’at dalam dua karya penting dalam Jam‘ al-Qira’at iaitu al-Tuhfat al-Mardiyyah dan al-Minah al-Ilahiyyah berdasarkan Qira’at al-Sab’ Tariq al-Shatibiyyah. Kedua-dua karya ini menjadi rujukan utama dalam bidang Ilmu Qira’at dari sudut praktikal Jam‘ al-Qira’at. Sumbangan kedua-dua karya ini sangat besar terhadap perkembangan Ilmu Qira'at khususnya dalam mengaplikasi bacaan secara Jam‘ al-Qira’at. Penerimaan kedua-dua karya ini tidak dapat dinafikan dalam konteks praktikal Jam‘ al-Qira’at al-Sab‘ Tariq al-Shatibiyyah. Dalam kajian ini, pendekatan yang digunakan adalah bersifat kualitatif iaitu menganalisis struktur dalam konteks Jam‘ al-Qira'at dan membuat perbandingan dalam dua karya tersebut. Hasil daripada kajian dan analisis pula ialah dapat mengetahui perbezaan kaedah kedua-dua karya tersebut yang digunakan dalam Jam‘ al-Qira'at selain dapat memahami hukum-hukum dan syarat-syarat berkaitan Jam‘ al-Qira'at. Jam' al-Qira'at is one of the methods of gathering Qira'at readings created to practice the appearance of al-Qira'at in reading the Qur'an. The Jam' al-Qira'at method is a reasonable step aimed at preserving and maintaining the appearance of al-Qira'at in the Qur'an as it was revealed. Therefore, this study was conducted to analyze and compare the method of Jam' al-Qira'at in two important books in Jam' al-Qira'at, namely al-Tuhfat al-Mardiyyah and al-Minah al-Ilahiyyah based on Qira'at al- Sab' Tariq al-Shatibiyyah. These two books are the main references in the field of Ilmu Qira'at from the practical point of view of Jam' al-Qira'at. The contribution of these two books is very great to the development of the Ilmu Qira'at, especially in the application of Jam' al-Qira'at reading. The acceptance of these two books cannot be denied in the practical context of Jam' al-Qira'at al-Sab' Tariq al-Shatibiyyah. In this study, the approach used is qualitative, which is to analyze the structure in the context of Jam' al-Qira'at and make comparisons in the two books. The result of the study and analysis is to be able to know the difference between the methods of the two works used in Jam' al-Qira'at as well as being able to understand the laws and conditions related to Jam' al-Qira'at.
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Karsono, Bambang. "Kedudukan Hukum Perma Nomor 2 Tahun 2012 dalam Mengefektivkan Pidana Denda pada Perkara Pencurian Ringan." KRTHA BHAYANGKARA 17, no. 3 (2023): 555–66. http://dx.doi.org/10.31599/krtha.v17i3.2903.
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The story of grandmother Minah who was tried for stealing three cocoa beans, or Basar and Kholil who were brought to trial for stealing a watermelon and a child with the initials AP (age 13) who was charged with stealing a bucket rope is a case of theft with a relatively small economic loss. Conditions at the same time became a contrast, when corruptors stealing large amounts of state money were only given too light sentences. Supreme Court Regulation of the Republic of Indonesia number 2 of 2012 addresses the discrepancy between the limitations of minor crimes and the amount of fines in the Criminal Code with the development of the dynamics of a society whose sense of justice is disturbed and various statutory regulations are no longer according to law in society. This normative juridical research aims to determine the capacity of PERMA No. 2 of 2012 in the legal hierarchies under the Criminal Code, especially in the criminal case of petty theft. Research findings in terms of effectiveness, fines are less effective when compared to prison sentences, especially in terms of the deterrent effect on convicts, because fines can be paid by other people.
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Zubaidah, Zubaidah. "Tathbiq Ta'lim al-Lughat al-'Arabiyyah 'Ala Asas Anmath al-Jumal li al-Thullab al-Hashilin 'Ala al-Minah BIDIKMISI." FUADUNA : Jurnal Kajian Keagamaan dan Kemasyarakatan 2, no. 2 (2019): 126. http://dx.doi.org/10.30983/fuaduna.v2i2.2073.
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<p><em>Learning qawaid nahwu (Arabic Grammar) is often considered difficult, especially for beginners in learning Arabic, even many people consider that Arabic is difficult. Learning Arabic for students who receive Bidik Misi scholarships for example, because these students come from different scientific backgrounds and schools and most of them are beginners and have never studied Arabic, therefore special methods and strategies are needed that are different from students who are have learned Arabic even from Pondok Pesantren. There are various ways and strategies used to overcome these difficulties, including by increasing the practice of simple and easy sentence patterns. The lecturer gives examples to students in the form of simple sentence patterns, then students can copy and then create new sentence patterns so that they can easily </em><em>understand</em><em> the qowa'id nahwu. For this reason, in this paper, it is explained the importance of understanding simple sentence patterns and examples of making sentences through sentence patterns for students who receive Bidik Misi scholarships at IAIN Bukittinggi.</em><em></em></p>
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Kusnadi, Kusnadi. "Ams|a>l Al-Qur’a>n Wa Aqsa>m Al-Qur’a>n." Jurnal Al-Mubarak: Jurnal Kajian Al-Qur'an dan Tafsir 3, no. 2 (2020): 1–16. http://dx.doi.org/10.47435/al-mubarak.v3i2.216.
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Al-Qur’an turun tidak bisa diabaikan begitu saja dengan tradisi Arab, sebab wilayah di mana ia diturunkan. Allah Swt. menyajikan al-Qur’an dalam beragam macam uslu>b yang tiap-tiap uslu>b memiliki kekhususan tersendiri. Salah satu kekhususan tersebut adalah adanya ams\al ang disajikan dalam al-Qur’an, yang salah satu tujuannya ialah sebagai alat untuk memperdalam kesan dalam hati pembaca dan pendengarnya serta berbicara dengan perasaan keagamaan yang ada dalam batin seseorang dengan bahasa yang indah dan penuh perasaan. Ams\al al-Qur’an adalah satu cara/metode yang menuntun pengkajinya agar memahami dan menerapkan ajaran Islam dengan baik dan benar, yang digubah dengan uslu>b bahasa yang sangat indah dan lemah lembut, agar dapat mewujudkan pengertian dalam pemikiran serta cara yang paling luwes dalam memantapkan pegangan seseorang pada prinsip yang seharusnya dipegangi. Ams\al al-Qur’an bila ditinjau dari bentuknya terdiri dari tiga yaitu: Musarrahah, kA>minah dan mursalah, yang ketiganya memberikan manfa’at yang sangat besar bagi orang-orang yang memperhatikannya. Ams\al menonjolkan sesuatu yang bersifat ma’qu>l (rasional), Menyingkap hakikat dan mengemukakan sesuatu yang tidak tampak, hingga seakan-akan menjadi tampak, menghimpun makna yang menarik dan indah dalam satu ungkapan yang singkat dan padat, menghindarkan seseorang dari perbuatan tercela, dan sebagainya.
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Son, Eugene, Sungsoo Kim, Haram Park, Minah Kim, and Hee Won Yang. "Abstract 5721: Dual targeting of CDK4/6 and CDK7 pathways augments tumor response in breast cancer." Cancer Research 84, no. 6_Supplement (2024): 5721. http://dx.doi.org/10.1158/1538-7445.am2024-5721.
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Abstract CDK7 plays a pivotal role in cell proliferation, serving as both a cell-cycle CDK regulator and a transcription machinery component. Clinical trials are currently exploring CDK7 inhibitors (CDK7i) as a second-line treatment for hormone receptor-positive (HR+) breast cancer post-CDK4/6 inhibitor (CDK4/6i) therapy progression and as a first-line treatment in triple-negative breast cancer (TNBC). This study evaluates the impact of CDK7i on transcription and CDKs activities and the synergistic potential of CDK7i in combination with CDK4/6i. Kinetic analyses indicate that CDK7i preferentially target global transcription over CDKs activities. Furthermore, a combination of CDK7i and CDK4/6i effectively suppresses cell proliferation in drug-naïve cells, albeit without the same efficacy in CDK4/6i-resistant cells. Our findings provide valuable insights into the evolving field of CDK inhibition strategies and provide critical guidance on the potential therapeutic application of CDK7i in breast cancer treatment. Citation Format: Eugene Son, Sungsoo Kim, Haram Park, Minah Kim, Hee Won Yang. Dual targeting of CDK4/6 and CDK7 pathways augments tumor response in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5721.
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Okky Irawan, Saverius Nahat, Tetty Nababan, Syafrida Syafrida, and Sufiarina Sufiarina. "Penegakkan Hukum di Negara Republik Indonesia." Federalisme: Jurnal Kajian Hukum dan Ilmu Komunikasi 2, no. 1 (2025): 21–28. https://doi.org/10.62383/federalisme.v2i1.479.
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Law enforcement serves as a fundamental mechanism for establishing order, security, and peace within society. It encompasses efforts to prevent or eliminate violations of the law, addressing issues both preventively and repressively. However, challenges arise when actions taken do not align with established procedures. The appropriate course of action within a legal framework is essential, and when discussing legal protection in the context of procedural law, it is important to clarify that such protection should not be interpreted as a means to shield offenders from accountability. This study seeks to evaluate law enforcement in Indonesia through the lenses of legal certainty, justice, and societal benefit. Employing a literature review methodology, which relies on expert opinions, the findings indicate notable deficiencies in the law enforcement system in Indonesia. For an extended period, those seeking justice within society have yearned for equitable law enforcement. Nevertheless, current practices in law enforcement tend to prioritize legal certainty over the community's sense of justice. Various court decisions, for example in the case of grandmother Minah and Aal, the sandal thief, seem to illustrate that law enforcement tends towards the view that law is law and has given rise to public disappointment with law enforcement in Indonesia.
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Mei Indrawati, Sri Saniyah, and Rusdiyanto Rusdiyanto. "Pengaruh Fasilitas Pendidikan Terhadap Prestasi Kerja Guru dengan Semangat Kerja Sebagai Variabel Intervening." Inisiatif: Jurnal Ekonomi, Akuntansi dan Manajemen 4, no. 1 (2025): 448–65. https://doi.org/10.30640/inisiatif.v4i2.3758.
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Sri Saniyah, 2024. The Influence of Educational Facilities on Teacher Work Performance with Teacher Work Morale as an Intervening Variable. Wijaya Putra University Postgraduate Program Surabaya. This type of research is explanatory research, the approach used is a quantitative approach, the research sample is 42 respondents. The analysis tool uses Smart PLS (Partial Least Square). Research objectives: 1) To describe educational facilities, work enthusiasm and teacher work performance at SMP Negeri 1 Torjun, Sampang Regency. 2) To test and analyze whether educational facilities have a significant effect on teacher work performance at SMP Negeri 1 Torjun, Sampang Regency. 3) To test and analyze whether teacher work enthusiasm has a significant effect on the work performance of teachers at SMP Negeri 1 Torjun, Sampang Regency. 4) To test and analyze whether educational facilities have a significant effect on the work spirit of teachers at SMP Negeri 1 Torjun, Sampang Regency. 5) To test and analyze whether educational facilities have a significant indirect effect on the work performance of teachers at SMP Negeri 1 Torjun Sampang Regency with work enthusiasm as an intervening variable. The research results show that: 1) Educational facilities have a significant effect on teacher work performance as evidenced by a p value of 0.039. 2) Educational facilities have a significant effect on work morale as evidenced by the p value of 0.002. 3) Teacher morale has a significant effect on teacher work performance as evidenced by a value of 0.001. 4) Educational facilities on teacher work performance with teacher work enthusiasm as an intervening variable have a significant effect with a p value of 0.040.
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Park, Jong Hoon, Yesol Kim, Je Yeong Ko, Soo-Been Lee, and Minah Park. "Abstract 5825: Reduced miR-371b-5p expression drives tumor progression via CSDE1/RAC1 regulation in triple-negative breast cancer." Cancer Research 82, no. 12_Supplement (2022): 5825. http://dx.doi.org/10.1158/1538-7445.am2022-5825.
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Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer; however, specific prognostic biomarkers have not yet been developed. In this study, we identified dysregulated microRNAs (miRNAs) in TNBC by profiling miRNA and mRNA expression. In patients with TNBC, miR-371b-5p expression was reduced, and miR-371b-5p overexpression significantly mitigated TNBC cell growth, migration, and invasion. In addition, we found that expression of cold shock domain-containing protein E1 (CSDE1), a direct target gene of miR-371b-5p, was upregulated in TNBC cells, and inhibition of CSDE1 expression alleviated TNBC cell growth by regulating RAC1 transcription. Mechanistically, CSDE1, phosphorylated C-terminal domain (p-CTD) of RNA polymerase II (RNAPII), and CDK7 form a complex, and downregulation of CSDE1 leads to weak interaction between RNAPII p-CTD and CDK7, resulting in a decrease in RNAPII p-CTD expression to reduce RAC1 transcript levels in CSDE1-deficient TNBC cells. Our data demonstrate that miR-371b-5p is a tumor-suppressive miRNA that regulates the CSDE1/Rac1 axis and could be a potential prognostic biomarker for TNBC. Citation Format: Jong Hoon Park, Yesol Kim, Je Yeong Ko, Soo-Been Lee, Minah Park. Reduced miR-371b-5p expression drives tumor progression via CSDE1/RAC1 regulation in triple-negative breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5825.
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Singh, Tejash Kumar. "Narrating Physical Diseases in the Malayan Landscape: Hugh Clifford’s “A Daughter of the Muhammadans”." IAFOR Journal of Arts & Humanities 11, no. 1 (2024): 103–14. http://dx.doi.org/10.22492/ijah.11.1.08.
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Diseases such as SARS, Ebola, Covid-19, and many others have swept across the world recently at pandemic and epidemic levels. These have impacted people regardless of ethnicity, while at the same time exposing glaring inequalities in treatment, separating those who can afford medical attention from those who cannot. These inequalities are due, in the main, to social and economic factors that were abundantly laid bare in mass media coverage. In the early 20th century, by contrast, disease and its treatment served to promote the colonialist agenda, with writers using physical and psychological depictions of the colonised body’s diseases in order to advance its fabricated “othering”. Among such colonial writers was Hugh Clifford (1866-1941), Resident and Governor in Malaya during the late nineteenth and early twentieth centuries. Documenting his experiences in Malaya in his short stories, Clifford constructed particular ontological realities regarding Malayan subjects for his European audiences, promoting a fabricated perception of their “difference”. In his short story “A Daughter of the Muhammadans”, published in his 1916 collection The Further Side of Silence, Clifford investigates the visually striking corruption of leprosy, juxtaposed against the wholesome, affectionate nature of Minah, the female Malayan subject. Based on the context of medicinal advancements, I will be proposing that Clifford’s physical and psychological depictions of the Malayan body’s diseases led to its constructed “othering”, especially through the furtherance of stereotypes of the Malayan subject that are inherent in his work.
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Singh, Tejash Kumar. "Narrating Physical Diseases in the Malayan Landscape: Hugh Clifford’s “A Daughter of the Muhammadans”." IAFOR Journal of Arts & Humanities 11, no. 1 (2024): 103–14. http://dx.doi.org/10.22492/ijah.11.2.08.
Full textAbstract:
Diseases such as SARS, Ebola, Covid-19, and many others have swept across the world recently at pandemic and epidemic levels. These have impacted people regardless of ethnicity, while at the same time exposing glaring inequalities in treatment, separating those who can afford medical attention from those who cannot. These inequalities are due, in the main, to social and economic factors that were abundantly laid bare in mass media coverage. In the early 20th century, by contrast, disease and its treatment served to promote the colonialist agenda, with writers using physical and psychological depictions of the colonised body’s diseases in order to advance its fabricated “othering”. Among such colonial writers was Hugh Clifford (1866-1941), Resident and Governor in Malaya during the late nineteenth and early twentieth centuries. Documenting his experiences in Malaya in his short stories, Clifford constructed particular ontological realities regarding Malayan subjects for his European audiences, promoting a fabricated perception of their “difference”. In his short story “A Daughter of the Muhammadans”, published in his 1916 collection The Further Side of Silence, Clifford investigates the visually striking corruption of leprosy, juxtaposed against the wholesome, affectionate nature of Minah, the female Malayan subject. Based on the context of medicinal advancements, I will be proposing that Clifford’s physical and psychological depictions of the Malayan body’s diseases led to its constructed “othering”, especially through the furtherance of stereotypes of the Malayan subject that are inherent in his work.
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Armand, Jessica, Sungsoo Kim, Kibum Kim, Eugene Son, Minah Kim, and Hee Won Yang. "Abstract 430: Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 430. https://doi.org/10.1158/1538-7445.am2025-430.
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Abstract The combination of CDK4/6 inhibitors (CDK4/6i) and endocrine therapy has revolutionized treatment for hormone receptor-positive (HR+) metastatic breast cancer. However, the emergence of resistance in most patients often leads to treatment discontinuation with no consensus on effective second-line therapies. The therapeutic benefits of maintaining CDK4/6i or incorporating CDK2 inhibitors (CDK2i) after disease progression remain unclear. Here, we demonstrate that sustained CDK4/6i therapy, either alone or combined with CDK2i, significantly suppresses the growth of drug-resistant HR+ breast cancer. Continued CDK4/6i treatment induces a noncanonical pathway for retinoblastoma protein (Rb) inactivation via post-translational degradation, resulting in diminished E2F activity and delayed G1 progression. Importantly, our data highlight that CDK2i should be combined with CDK4/6i to effectively suppress CDK2 activity and overcome resistance. We also identify cyclin E overexpression as a key driver of resistance to CDK4/6 and CDK2 inhibition. These findings provide crucial insights into overcoming resistance in HR+ breast cancer, supporting the continued use of CDK4/6i and the strategic incorporation of CDK2i to improve therapeutic outcomes. Citation Format: Jessica Armand, Sungsoo Kim, Kibum Kim, Eugene Son, Minah Kim, Hee Won Yang. Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 430.
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BIZJAK, MATJAŽ. "MINSKA NEVARNOST NA KOSOVU V OBDOBJU OD 1999 DO 2001." KONCEPT KREPITVE ODPORNOSTI DRUŽBE/THE CONCEPT OF STRENGHTENING THE RESILIENCE OF SOCIETY, VOLUME 22/ISSUE 4 (October 23, 2020): 107–33. http://dx.doi.org/10.33179/bsv.99.svi.11.cmc.22.4.6.
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Povzetek Mine sta na Kosovu polagali tako jugoslovanska stran kot tudi kosovsko-albanske oborožene formacije. Program humanitarnega razminiranja se je začel izvajati takoj po koncu vojaških aktivnosti in je bil končan decembra 2001. Podatki o postavljenih minah so se zbirali že od začetka sovražnosti. Začetne ocene minske nevarnosti so bile pretirane. Na jugoslovanski strani so mine polagali vojska, enote ministrstva za notranje zadeve in paravojaki. Jugoslovanska vojska je polagala mine skladno s taktiko JLA. Nasprotna kosovsko-albanska stran je polagala predvsem manjše skupine min. Glede na vojaško-tehnični sporazum je jugoslovanska vojska enotam Kforja predala 624 zapisnikov minskih polj. Na Kosovu so mine polagali še po koncu spopadov. Ključne besede protitankovske mine, protipehotne mine, humanitarno razminiranje, Kosovo. Abstract In Kosovo, landmines were laid by both parties involved. The humanitarian demining program started immediately after the end of the military activities and was successfully completed in December 2001. Data on the landmines were collected from the beginning of the hostilities. According to various information, the initial mine risk assessments were exaggerated. On the Yugoslav side, landmines were used by the military, units of the Ministry of the Interior and paramilitary units. The Yugoslav Army was laying mines in line with the tactics of the Yugoslav People’s Army. The opposing Kosovo-Albanian side, however, was mainly laying small groups of landmines. According to the military technical agreement, the Yugoslav Army handed over 624 minefield records to KFOR units. In Kosovo, landmines were also being laid after the end of the conflict. Key words Anti-tank landmines, anti-personnel landmines, humanitarian demining, Kosovo.
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Alimin, A. A., and Netty Yuniarti. "Sikap Bahasa Masyarakat Tutur Bahasa Melayu Dialek Sambas di Desa Sungai Itik Kec. Sungai Kakap, Kab. Kubu Raya." JP-BSI (Jurnal Pendidikan Bahasa dan Sastra Indonesia) 7, no. 2 (2022): 68. http://dx.doi.org/10.26737/jp-bsi.v7i2.2823.
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Tujuan dari penelitian ini adalah untuk mengukur dan mendeskripsikan sikap bahasa masyarakat tutur Bahasa Melayu Dialek Sambas yang terdapat di Desa Sungai Itik, Kec. Sungai Kakap, Kab. Kubu Raya. Metode Penelitian ini menggunakan jenis penelitian deskriptif kuantitatif. Pada penelitian dideskripsikan bentuk sikap BMDS pada masyarakat tutur melalui perhitungan statistik sederhana dalam menentukan pernyataan sikap bahasa positif atau negatif. Adapun sampel dalam penelitian ini adalah masyarakat tutur di Dusun Melati lebih tepatnya masyarakat yang menetap di sepanjang Parit Cek Minah, yaitu RT 7, RT 8, dan RT 23 yang melibatkan 20 Responden. Teknik pengumpulan dengan menggunakan teknik komunikasi tidak langsung (pengisian angket) diperkuat dengan teknik komunikasi langsung/interview, serta teknik catat dan rekam. Hasil penelitian menunjukan masyarakat tutur BMDS yang ada di Desa Sungai Itik memiliki Sikap Positif Terhadap Bahasanya sendiri dan sikap positif tersebut juga ditunjukan terhadap bahasa Indonesia meskipun masih jauh dibawah BMDS. Hal ini menunjukan bahwa masyarakat tersebut memiliki sikap kebanggaan berbahasa, kesetiaan berbahasa dan kesadaran akan norma bahasa jauh lebih tinggi terhadap BMDS dibandingkan dengan bahasa lain. Berdasarkan analisis data, sikap bahasa penutur terhadap BMDS pada aspek: 1. kebanggaan menggunakan BMDS diperoleh skor persentase rata-rata 90, 2. Aspek Kesetiaan menggunakan BMDS dengan skor persentase rata-rata 82, 3. Aspek kesadaran akan norma diperoleh skor persentase rata-rata 74. Sedangkan pada sikap bahasa penutur terhadap Bahasa Indonesia pada aspek: 1. Kebanggaan menggunakan Bahasa Indonesia diperoleh skor persentase rata-rata 78, 2. Aspek Kesetiaan menggunakan Bahasa Indonesia dengan skor persentase rata-rata 70, 3. Aspek kesadaran akan norma diperoleh skor persentase rata-rata 68
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Andriyani, Lenna, Hartiwiningsih, and Pujiyono Suwadi. "Reconceptualization of Restorative Justice in The Attorney General's Office of The Republic of Indonesia." Revista de Gestão Social e Ambiental 18, no. 1 (2024): e04697. http://dx.doi.org/10.24857/rgsa.v18n1-053.
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Purpose: This article examines the regulatory framework and practical application of restorative justice by the Indonesian Prosecutor's Office. The adoption of restorative justice in Indonesia has been delayed by the legalistic and formalistic nature of the Indonesian Criminal Procedure. Theoretical framework: To address this issue, an Attorney General Regulation has been put in place to oversee and regulate restorative justice practices. Nevertheless, there are still uncertainties regarding the alignment between the Prosecutor's Office's restorative justice concept and its fundamental nature. Methods: This study uses a normative legal methodology to conduct qualitative research. The research indicates that the Prosecutor's Regulations on Restorative Justice are inherently linked to Indonesia's historical framework of law enforcement. Results and Conclusion: Consequently, prosecutors continue to handle minor instances, such as those involving Grandma Minah and Grandpa Samirin, much to the public's discontent. In Indonesia, this is evident in the high concentration of prisons. Research implications: According to this research, there should not be a connection between restorative justice and the resolution of a case. Restorative justice is distinct from the prosecutor's ability to dismiss a case based on the availability of options. Restorative justice aims to reinstate the "initial condition" and safeguard victims. Originality/value: This redirects the emphasis of restorative justice from halting the case to reinstating it. Restorative justice is a criminal framework that enables prosecutors to pursue alternative forms of prosecution and employ non-incarceration penalties. Prosecutors can utilize restorative justice both before and after the legal process, as well as during the legal process.
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Park, Ha-Ram, Anahita Shiva, Portia Cummings, et al. "Abstract 4588: Vascular regulation of T-cell exclusion in melanoma." Cancer Research 83, no. 7_Supplement (2023): 4588. http://dx.doi.org/10.1158/1538-7445.am2023-4588.
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Abstract T-cell position in the tumor microenvironment determines the probability of target encounter and tumor killing. CD8+ T-cell exclusion from the tumor parenchyma is associated with poor response to immunotherapy and yet the biology that underpins this distinct pattern remains unclear. Here we show that the vascular destabilizing factor angiopoietin-2 (ANGPT2) causes compromised vascular integrity in the tumor periphery, leading to impaired T-cell infiltration within tumor. We analyzed the spatial regulation of ANGPT2 in whole tumor cross-sections and its impact on CD8+ T-cell position, vascular integrity, and response to immunotherapy using syngeneic murine melanomas. We found that T-cell exclusion was associated with peritumoral expression of ANGPT2 and elevated vascular leakage in human and murine melanomas. Both pharmacological and genetic blockade of ANGPT2 promoted CD8+ T-cell infiltration to the tumor core, exerting antitumor effects. Importantly, the reversal of T-cell exclusion following ANGPT2 blockade not only enhanced response to anti-PD-1 therapy in immunogenic, therapy responsive mouse melanomas, but also rendered non-responsive tumors susceptible. Therapeutic response after ANGPT2 blockade, driven by improved CD8+ T-cell infiltration, coincided with TIE2 signaling activation and increased vascular integrity in the tumor periphery, indicating that maintenance of vascular integrity within tumors is necessary for robust response to immunotherapy. These data highlight ANGPT2/TIE2 signaling as a key mediator of T-cell exclusion and a promising target to potentiate checkpoint inhibitor efficacy in melanoma. Citation Format: Ha-Ram Park, Anahita Shiva, Portia Cummings, Richard Carvajal, Gavin Thurston, Joon-Yong An, Amanda W. Lund, Hee Won Yang, Minah Kim. Vascular regulation of T-cell exclusion in melanoma. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4588.
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Kim, Sungsoo, Richard Carvajal, Minah Kim, and Hee Won Yang. "Abstract 3876: Kinetics of RTK activation determine ERK signaling dynamics and resistance to BRAF and MEK inhibitors." Cancer Research 83, no. 7_Supplement (2023): 3876. http://dx.doi.org/10.1158/1538-7445.am2023-3876.
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Abstract Combination treatment of BRAF inhibitor (BRAFi) and MEK inhibitor (MEKi) produces remarkable response rates and is expected to prevent ERK activation in BRAF-mutant melanoma. However, sporadic ERK reactivation occurs in melanoma models, and efficacy is severely limited by the emergence of drug resistance. The underlying molecular mechanisms that drive ERK reactivation and adaptation to BRAFi/MEKi remain elusive. Here, using single-cell imaging and optogenetic approaches, we show that the strength and duration of receptor tyrosine kinase (RTK) activation determines ERK reactivation and the development of BRAFi/MEKi-resistant cells. Single-cell data reveal that despite global RTK activation by the same external stimuli, only small subsets of melanoma cells induce effective RTK and ERK activation to develop BRAFi/MEKi resistance. Furthermore, by directly controlling RTK activity, we demonstrate that the kinetics of RTK activation determine ERK signaling dynamics and the percentage of drug-resistant cells. While these drug-resistant cells are rare during early stages of drug treatment, they eventually become the dominant population through sustained RTK-mediated ERK activation that drives cell proliferation. Thus, RTK activation in established drug-resistant cells causes effective ERK activation and cell proliferation. Importantly, limiting RTK signaling activation reverses the BRAFi/MEKi-resistant state. We show that targeting SHP2, a mediator of RTK signaling, effectively suppresses RTK-mediated ERK activation and cell proliferation in BRAFi/MEKi-resistant cells. Our results provide mechanistic insights into the contribution of heterogeneity in RTK activation kinetics to ERK reactivation and BRAFi/MEKi resistance, also highlighting SHP2 activity as a promising target to overcome drug resistance in BRAF-mutant melanoma. Citation Format: Sungsoo Kim, Richard Carvajal, Minah Kim, Hee Won Yang. Kinetics of RTK activation determine ERK signaling dynamics and resistance to BRAF and MEK inhibitors. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3876.
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Park, Ha-Ram, Hee Won Yang, and Minah Kim. "Abstract 5389: Development of T-cell exclusion in melanoma." Cancer Research 84, no. 6_Supplement (2024): 5389. http://dx.doi.org/10.1158/1538-7445.am2024-5389.
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Abstract Immune checkpoint inhibitors (ICIs), which prevent immune cell exhaustion and boost an antitumor response, have shown remarkable treatment efficacy in patients with advanced melanoma. However, its efficacy is limited by the emergence of resistance associated with an immunosuppressive tumor microenvironment (TME). The contribution of abnormal tumor vasculature to limited immune cell infiltration into the tumor core has been reported but the mechanisms of its development are still elusive. We analyzed how tumor angiogenesis affects the immune cell exclusion at different time points of primary melanoma using syngeneic murine melanomas. The spatial distribution of various immune cell populations and vascular integrity were analyzed in whole tumor cross-sections via multiplex immunofluorescence staining. We found that the exclusion pattern of CD8+ T cells was less evident with a balanced distribution across the whole tumor regions at the early stage. However, as the tumor grows, there is a pronounced accumulation of CD8+ T cells at the tumor periphery with a conspicuous absence in the core. Tumor blood vessels were structurally uniform and functionally stable in the early developmental tumor but became unstable and leaky as the tumor progressed, which was associated with the development of CD8+ T-cell exclusion. To understand the mechanism underlying vascular regulation of immune exclusion during tumor progression, we will investigate the expression of genes related to tumor angiogenesis using spatial transcriptomic analysis and RNA sequencing of endothelial cells (CD45+CD31-) sorted from the murine melanomas. These results highlight the contribution of spatial tumor vascular destabilization to the T-cell exclusion development, implying the potential of targeting tumor vasculature to enhance immune activation and the therapeutic efficacy of ICI in melanoma. Citation Format: Ha-Ram Park, Hee Won Yang, Minah Kim. Development of T-cell exclusion in melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5389.