Relevant bibliographies by topics / Alb-uPA

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Alb-uPA'

Author: Grafiati
Published: 4 June 2021
Last updated: 3 February 2022

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Journal articles on the topic "Alb-uPA"

1

Osna, Natalia A., Kusum K. Kharbanda, Yimin Sun, et al. "Ethanol affects hepatitis C pathogenesis: Humanized SCID Alb-uPA mouse model." Biochemical and Biophysical Research Communications 450, no. 1 (2014): 773–76. http://dx.doi.org/10.1016/j.bbrc.2014.06.048.

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Bai, Jiasi, Jungang Li, and Qing Mao. "Construction of a Single Lentiviral Vector Containing Tetracycline-Inducible Alb-uPA for Transduction of uPA Expression in Murine Hepatocytes." PLoS ONE 8, no. 4 (2013): e61412. http://dx.doi.org/10.1371/journal.pone.0061412.

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Sari, Gulce, Gertine W. van Oord, Martijn D. B. van de Garde, Jolanda J. C. Voermans, Andre Boonstra, and Thomas Vanwolleghem. "Sexual Dimorphism in Hepatocyte Xenograft Models." Cell Transplantation 30 (January 1, 2021): 096368972110061. http://dx.doi.org/10.1177/09636897211006132.

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Humanized liver mouse models are crucial tools in liver research, specifically in the fields of liver cell biology, viral hepatitis and drug metabolism. The livers of these humanized mouse models are repopulated by 3-dimensional islands of fully functional primary human hepatocytes (PHH), which are notoriously difficult to maintain in vitro. As low efficiency and high cost hamper widespread use, optimization is of great importance. In the present study, we analyzed experimental factors associated with Hepatitis E virus (HEV) infection and PHH engraftment in 2 xenograft systems on a Nod-SCID-IL2Ry-/- background: the alb-urokinase plasminogen activator mouse model (uPA-NOG, n=399); and the alb-HSV thymidine kinase model (TK-NOG, n = 198). In a first analysis, HEV fecal shedding in liver humanized uPA-NOG and TK-NOG mice with comparable human albumin levels was found to be similar irrespective of the mouse genetic background. In a second analysis, sex, mouse age at transplantation and hepatocyte donor were the most determinant factors for xenograft success in both models. The sexual imbalance for xenograft success was related to higher baseline ALT levels and lower thresholds for ganciclovir induced liver morbidity and mortality in males. These data call for sexual standardization of human hepatocyte xenograft models, but also provide a platform for further studies on mechanisms behind sexual dimorphism in liver diseases.
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Kneteman, Norman M., Amy J. Weiner, John O'Connell, et al. "Anti-HCV therapies in chimericscid-Alb/uPA mice parallel outcomes in human clinical application." Hepatology 43, no. 6 (2006): 1346–53. http://dx.doi.org/10.1002/hep.21209.

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HSI, B., E. HSU, C. RICHARDSON, L. TYRRELL, and N. KNETEMAN. "61 Inducing apoptosis in hepatitis C infected Alb-UPA/SCID mice with gene therapy mechanisms." Hepatology 38 (2003): 184. http://dx.doi.org/10.1016/s0270-9139(03)80104-0.

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Mohajerani, S. A., M. Nourbakhsh, A. Cadili, J. R. Lakey, and N. M. Kneteman. "Transplant of Primary Human Hepatocytes Cocultured with Bone Marrow Stromal Cells to SCID Alb-uPA Mice." Cell Medicine 1, no. 2 (2010): 81–92. http://dx.doi.org/10.3727/215517910x536627.

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Brezillon, Nicolas, Marie-Noëlle Brunelle, Hélène Massinet, et al. "Antiviral Activity of Bay 41-4109 on Hepatitis B Virus in Humanized Alb-uPA/SCID Mice." PLoS ONE 6, no. 12 (2011): e25096. http://dx.doi.org/10.1371/journal.pone.0025096.

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Joyce, Michael A., Kathie-Anne Walters, Sue-Ellen Lamb, et al. "HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice." PLoS Pathogens 5, no. 2 (2009): e1000291. http://dx.doi.org/10.1371/journal.ppat.1000291.

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HSI, B., D. SCHILLER, K. FISCHER, et al. "251 Establishing the validity of the ALB-UPA/SCID mouse model of HCV in the testing of anti-viral therapies." Hepatology 38 (2003): 278. http://dx.doi.org/10.1016/s0270-9139(03)80294-x.

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10

Walters, Kathie-Anne, Michael A. Joyce, Jill C. Thompson, et al. "Host-Specific Response to HCV Infection in the Chimeric SCID-beige/Alb-uPA Mouse Model: Role of the Innate Antiviral Immune Response." PLoS Pathogens 2, no. 6 (2006): e59. http://dx.doi.org/10.1371/journal.ppat.0020059.

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Dissertations / Theses on the topic "Alb-uPA"

1

Hsi, Dickie Belinda. "Advancing the Alb-uPA/SCID/Bg Chimeric Mouse." Phd thesis, 2009. http://hdl.handle.net/10048/765.

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The feasibility of the Alb-uPA/SCID/Bg chimeric mouse as a model for Hepatitis C Virus (HCV) infection was assessed experimentally by (1) the infection and treatment with another hepatotropic virus, Hepatitis B Virus (HBV) and (2) the infection of the model with HCV and the subsequent treatment of that infection with a pro-apoptotic factor (BID) targeted to infected hepatocytes. In the former, the infected mouse responded favorably, and in the manner of human patients, to a standard imunoglobulin therapy. In the latter, HCV-infected hepatocytes were successfully targeted for cell death, with repeated doses of Adenovirus-delivered BID being the most effective at inhibiting virus spread. Efficacy and toxic side-effects of BID treatment could be reconciled by modulating the timing between doses, the most effective tested being three doses of BID at 7-day intervals. Analyses of chimeric model production were undertaken to improve the quality of human hepatocyte engraftment (typically only 25-35% of mice receiving grafts are currently used experimentally). Minor variations in success rates were experienced with respect to donor age or health status, or the age of recipient mice within an operational window of 5 to 13 days from birth. The greatest obstacle to useful engraftment (aside from technical challenges) was deemed to be the genetic/cellular integrity of the recipient mouse. This conclusion was based on variable engraftment success with ‘healthy’ donor cell preparations and a consideration of variability in immune deficiency arising in mice within a SCID/Bg mouse colony.<br>Experimental Surgery
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2

Dickie, Belinda Hsi. "Advancing the Alb-uPA/SCID/Bg chimeric mouse model for hepatitis C virus infection." 2009. http://hdl.handle.net/10048/765.

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Thesis (Ph.D.)--University of Alberta, 2009.<br>A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor in Philosophy in Experimental Surgery, Department of Surgery. Title from pdf file main screen (viewed on October 13, 2009). Includes bibliographical references.
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