Journal articles: 'Albinos Wistar'

1

Oliveira, Paula Alexandra, and Ana Faustino Ana Faustino. "A história do rato de laboratório: do ódio ao amor." História da Ciência e Ensino: construindo interfaces 20 (December 29, 2019): 115–25. http://dx.doi.org/10.23925/2178-2911.2019v20espp115-125.

Full text

Abstract:

ResumoO rato está na base de importantes descobertas na área da medicina. Contudo, nem sempre foi bem visto pela sociedade. No século XIV abateu-se sobre a Europa uma pandemia, a Peste Negra, causada por uma bactéria (Yersinia pestis) transmitida ao Homem por uma pulga (Xenopsylla cheopis), cujo hospedeiro era o rato (Rattus rattus). Esta doença vitimou aproximadamente 150 milhões de pessoas. Estava-se longe de imaginar o contributo que o rato viria a ter na saúde humana.No século XVII o rato proliferou descontroladamente, surgindo uma nova profissão: os caçadores de ratos. Estes indivíduos ganhavam dinheiro com a captura e venda destes animais para alimentação. Nessa época apareceu um desporto novo e as apostas a ele associadas: as lutas de ratos. Como resultado desse desporto, aumentaram os acasalamentos consanguíneos e surgiram variações na pelagem do rato, aparecendo os primeiros ratos albinos. Em 1828 foram utilizados os primeiros ratos albinos num ensaio experimental sobre o estudo do efeito do jejum. Mais tarde, em 1906, no Instituto Wistar, Helen Dean King desenvolveu uma estirpe a partir dos ratos albinos, designada de Wistar, para uso na investigação biomédica.Ainda no século XX o uso do rato de laboratório alargou-se a estudos de aprendizagem em labirinto, nutrição, reprodução, genética e cancro, e consequentemente mais estirpes de animais foram desenvolvidas, passando a existir empresas com o propósito de os vender para investigação. A importância desta espécie pode comprovar-se pela análise do número de artigos publicados anualmente com recurso à sua utilização. Neste trabalho apresenta-se uma revisão histórica do uso do rato na investigação, evidenciando-se as caraterísticas que fizeram deste animal um modelo único na pesquisa biomédica. Palavras-chave: Investigação, Peste Negra, Rattus rattus, Wistar Abstract The rat is the basis of important findings in Medicine. However, it was not always well-seen by the society. In the 14th century, the Europe was affected by a pandemic disease, Black Pestis, caused by a bacterium (Yersinia pestis) transmitted to the Man by a flea (Xenopsylla cheopis), whose host was the rat (Rattus rattus). This disease victimized approximately 150 million people. It was far from imaging the contribution that the rat would have for human health. In the 17th century, the rat proliferated wildly, emerging a new job: the rat hunters. These people earnt money with the capture and selling of these animals for food. At that time appeared a new sport and the bets associated to it: the rat fights. Because of this new hobby, the consanguineous mating increased and appeared variations on rat coat, appearing the first albino rats. In 1828 the albino rats were used by the first time in an experimental assay about the fasting effects. Later, in 1906, in the Wistar Institute, Helen Dean King developed a strain from albino rats, called Wistar, for use in biomedical research. Still in the 20th century, the use of laboratory rats was expanded to studies of learning, nutrition, reproduction, genetics and cancer, and consequently more strains were developed by companies with the purpose to sell them for research. The importance of this specie may be evidenced by the analysis of the number of scientific works published annually using it. In this work, a historical review of the use of the rat in the investigation is provided, evidencing the characteristics that made it a unique model in biomedical research. Keywords: Black Pestis, Investigation, Rattus rattus, Wistar

APA, Harvard, Vancouver, ISO, and other styles

2

Chapadeiro, E., P. S. S. Beraldo, P. C. Jesus, W. P. Oliveira Jr., and L. F. Junqueira Jr. "Lesões cardíacas em ratos wistar inoculados com diferentes cepas do Trypanosoma cruzi." Revista da Sociedade Brasileira de Medicina Tropical 21, no. 3 (1988): 95–103. http://dx.doi.org/10.1590/s0037-86821988000300002.

Full text

Abstract:

Ratos albinos Wistar infectados com diferentes inóculos das cepas Y, Colombiana (COL) e São Felipe (12SF) do Trypanosoma cruzi desenvolveram parasitemia elevada entre 14e21 dias, a qual tomou-se desprezível ou desapareceu completamente ao final da 4ª semana. As lesões do coração foram avaliadas, semiquantitativamente, pelo sistema de "scores", conforme a intensidade e a extensão da inflamação, nas diferentes estruturas do órgão, tendo sido observado que: a) na fase inicial (aguda) da infecção, os animais mortos espontaneamente ou em conseqüência de acidente anestésico apresentaram cardite de intensidade moderada à acentuada, não havendo diferença em relação às cepas utilizadas; as diferentes estruturas do coração estavam uniformemente comprometidas; b) na fase crônica da infecção observou-se cardite degrau leve a moderado e as lesões foram mais freqüentes e intensas quanto maior o inoculo empregado; no entanto, inóculos baixos só produziram lesões quando a cepa utilizada foi a Colombiana. Trombose mural nos átrios e dilatação da ponta do ventrículo esquerdo foram observadas em 20% dos animais, independentemente da cepa. Na fase crônica 15% dos animais apresentaram miocardite crônica com fibrose, associada à hipertrofia das miocélulas. Os AA confirmam ser o rato albino suscetível à infecção chagásica e, portanto, um modelo útil no estudo das manifestações cardíacas da Doença de Chagas.

APA, Harvard, Vancouver, ISO, and other styles

3

Alves, Elaine, Carlos Rangel, Alexandre Garcia, Maurícia Cammarota, and Paulo Tubino. "Técnica para produção de criptorquia experimental em ratos." Acta Cirurgica Brasileira 12, no. 2 (1997): 125–29. http://dx.doi.org/10.1590/s0102-86501997000200010.

Full text

Abstract:

Foram utilizados 18 ratos machos albinos Wistar, divididos em dois grupos de acordo com a idade e a época do sacrifício. Todos foram submetidos ao fechamento do ânulo inguinal superficial esquerdo para a produção de criptorquia experimental. Os animais de ambos os grupos sobreviveram ao procedimento e foram sacrificados no 30º. e no 60º. dias de pós-operatório. Todos apresentavam o testículo esquerdo retido.

APA, Harvard, Vancouver, ISO, and other styles

4

Pinheiro, Maria da Conceição Nascimento, Paulo Sérgio Siebra Beraldo, Luiz Fernando Junqueira Júnior, Edison Reis Lopes, and Edmundo Chapadeiro. "Análise quantitativa de mastócitos e de granulócitos eosinófilos no miocárdio de ratos wistar cronicamente infectados pelo Trypanosoma cruzi. Contribuição ao conhecimento da fibrose miocárdia." Revista da Sociedade Brasileira de Medicina Tropical 25, no. 1 (1992): 45–50. http://dx.doi.org/10.1590/s0037-86821992000100007.

Full text

Abstract:

Foi feito o estudo quantitativo de mastócitos e de granulócitos eosinófilos no miocárdio de 40 ratos albinos Wistar. Trinta animais encontravam-se nafase tardia da infecção (8º mês) produzida pelas cepas São Felipe, Y e Colombiana do Trypanosoma cruzi, e apresentavam graus variáveis de miocardite crônica; 10 ratos serviram como controles. Miocardite crônica fibrosante (fibrose) ocorreu em 40% dos animais infectados e detectou-se aumento do número de mastócitos nos animais, chagásicos, o qual se associou à infecção mas não à fibrose miocárdica. Não se constatou aumento do número de eosinófilos.

APA, Harvard, Vancouver, ISO, and other styles

5

Castagno, Lucio Almeida, and Luiz Lavinksy. "Cicatrização da membrana timpânica na timpanocentese com laser de argônio comparado à técnica com microlanceta: estudo experimental em ratos." Revista Brasileira de Otorrinolaringologia 72, no. 6 (2006): 794–99. http://dx.doi.org/10.1590/s0034-72992006000600010.

Full text

Abstract:

Otite média secretora (OMS) e otite média aguda recorrente (OMAR) podem necessitar tratamento cirúrgico para adequada ventilação da orelha média. A abertura clássica do tímpano (timpanocentese) requer incisão por microlanceta sob controle de microscópio cirúrgico e mantém-se patente por alguns dias. Estudos recentes sugerem que a timpanocentese feita por diferentes lasers pode permanecer permeável por maior tempo, o que possibilitaria a normalização da otite média. MATERIAL E MÉTODOS: Neste estudo experimental 34 ratos linhagem Wistar, albinos, machos adultos pesando cerca de 300g, foram anestesiados com cetamina 27 mg/kg e xilazina 2,7 mg/kg. A seguir, foram submetidos à timpanocentese incisional com microlanceta no ouvido direito (ML-OD), e à timpanocentese mediada por laser de argônio no ouvido esquerdo (LA-OE). RESULTADOS: Não houve diferença significativa no tempo de cicatrização das timpanocenteses feitas com laser de argônio ou microlanceta. Todas as timpanocenteses cicatrizaram em 10 dias. CONCLUSÃO: A timpanocentese com laser de argônio apresentou patência e cicatrização semelhantes à técnica clássica com microlanceta realizada em ratos Wistar sem enfermidades de orelha média.

APA, Harvard, Vancouver, ISO, and other styles

6

Diallo, Mama Sy. "Histopathologic study of Liver Tissue from Wistar Albinos Rats Treated with Methanolic Extract of Leptadenia Hastata’s Roots." American Journal of Biomedical Science & Research 7, no. 6 (2020): 499–504. http://dx.doi.org/10.34297/ajbsr.2020.07.001209.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Amraoui, Wahiba, Nesrine Adjabi, Fatiha Bououza, et al. "Modulatory Role of Selenium and Vitamin E, Natural Antioxidants, against Bisphenol A-Induced Oxidative Stress in Wistar Albinos Rats." Toxicological Research 34, no. 3 (2018): 231–39. http://dx.doi.org/10.5487/tr.2018.34.3.231.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Nyonseu Nzebang, Doriane Camille, Marie Ide Ngaha Njila, Emma Fortune Bend, et al. "Evaluation of the toxicity of Colocasia esculenta (Aracaceae): Preliminary study of leaves infected by Phytophthora colocasiae on wistar albinos rats." Biomedicine & Pharmacotherapy 99 (March 2018): 1009–13. http://dx.doi.org/10.1016/j.biopha.2017.12.061.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Rossi Junior, Wagner Costa, Livia Cecília de Oliveira Barbosa, and Alessandra Esteves. "Avaliação do potencial osteogênico do periósteo em associação com uma membrana de colágeno." Acta Ortopédica Brasileira 18, no. 6 (2010): 327–30. http://dx.doi.org/10.1590/s1413-78522010000600004.

Full text

Abstract:

OBJETIVOS: Este trabalho avaliou o potencial osteogênico de enxertos de periósteo livre associado a uma membrana de colágeno. MÉTODOS: Vinte ratos albinos Wistar com idade média de 100 dias foram submetidos à cirurgia para criação de um defeito ósseo de 2,5 a 3,0 mm de comprimento na diáfise das fíbulas. Após 30 dias os animais foram então divididos em dois grupos: Grupo I recebeu o implante de periósteo associado à membrana de colágeno e Grupo II, somente a membrana de colágeno. Os animais foram radiografados antes do implante de periósteo e 15 ou 30 dias após o mesmo. RESULTADOS: Os resultados mostraram que o enxerto de periósteo livre associado à membrana de colágeno não foi eficiente no processo de reparo do defeito ósseo. CONCLUSÃO: Sugere-se que enxertos periosteais não vascularizados não apresentam potencial para formar novo osso. O fato de o enxerto ter sido implantado 30 dias após a criação do defeito ósseo interferiu negativamente no processo de osteogênese.

APA, Harvard, Vancouver, ISO, and other styles

10

Pedrosa, Lúcia F. C., and Silvia M. F. Cozzolino. "Efeito da suplementação com ferro na biodisponibilidade de zinco em uma dieta regional do nordeste do Brasil." Revista de Saúde Pública 27, no. 4 (1993): 266–70. http://dx.doi.org/10.1590/s0034-89101993000400006.

Full text

Abstract:

Foram investigados os efeitos da suplementação com ferro na biodisponibilidade de zinco de uma dieta "regional" do Nordeste (DRNE), em ratos albinos Wistar, consumindo rações à base da referida dieta (DRNE) e rações controle. As rações DRNE, continham 16 mg de Zn/kg e níveis de 35 mg, 70 mg e 140mg Fe/kg. As rações controle foram elaboradas segundo o "Committee on Laboratory Animal Diets", contendo níveis de proteína, ferro e zinco ajustados aos das rações experimentais DRNE. Os parâmetros utilizados para medir a biodisponibilidade do zinco foram: Índice de Absorção Aparente do Zn e nível total de Zn nos fêmures. Os resultados obtidos demonstraram que a suplementação com ferro diminuiu a biodisponibilidade do Zn, e os efeitos dessa interferência foram influenciados pela qualidade da dieta e pelas proporções Fe:Zn. Tal fato deve ser considerado nas práticas que envolvem fortificação de alimentos e/ou suplementos medicamentosos, comuns nas populações com carências nutricionais.

APA, Harvard, Vancouver, ISO, and other styles

11

Fatiha, Benahmed, Hayet Fatima Zohra Belhouari, Radjaa Bounoura, Elazhari Mehrab, and Omar Kharoubi. "Toxicity of mercury on the brain: ability of extract of Pistacia atlantica regulated effect." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 17–24. http://dx.doi.org/10.22270/jddt.v10i4-s.4269.

Full text

Abstract:

Objective: The purpose of this study was to evaluate the neuroprotective effect of 150 mg / kg extract of the plant Pistacia atlantica against mercury-induced oxidative stress Methods: Hg was administered intraperitoneally (2,5 mg/kg body weight, one time a week), and P. atlantica and were given orally by gavage at a daily dose (150 mg/kg body weight) to rats for 32 days. 24 male adult Albinos Wistar rats were divided into four groups: group 1 Control, group 2 (HgCl2) group 3 (Hg + P. atlantica) and group 4 (P. atlantica). Paramatrical tests of oxidative stress and histological sections of the cerebral parenchyma. Results: Our results showed that the intraperitoneal injection of mercury chloride HgCl2 causes deleterious effects in the brain resulting in: a failure of redox status by disrupting the antioxidant defense system by a significant decrease in the activity of catalase glutathione peroxidase, glutathione-s-transferase and superoxide dismutase acetylcholinesterase and increase of the activity of the enzyme lactate dehydrogenase. The levels of lipid peroxidation markers were high in TBARS intoxicated rats with protein oxidation increased in the brain intoxicated by. The continuous use of mercury is also at the origin, in brain tissue However, supplementation of P. atlantica extract with mercury-treated rats attenuated some of the harmful and toxic effects of this metal. This clearly demonstrates the protective roles of this plant Keywords: mercury, Pistacia atlantica, Wistar rat, brain, antioxidant, neurotoxicity.

APA, Harvard, Vancouver, ISO, and other styles

12

Cavaliere, Maria J., Edenilson E. Calore, Nilda M. Perez, and Flávio Rodrigues Puga. "Miotoxicidade por organofosforados." Revista de Saúde Pública 30, no. 3 (1996): 267–72. http://dx.doi.org/10.1590/s0034-89101996000300010.

Full text

Abstract:

Os organofosforados são um grupo de compostos químicos amplamente utilizados em agropecuária como inseticidas, ocasionando intoxicações acidentais em animais e humanos, e mesmo sendo utilizados em tentativas de suicídio. A toxicidade desses produtos decorre sobretudo de insuficiência cárdio-respiratória por compromentimento do sistema nervoso autônomo. Sabe-se que alguns destes compostos induzem em animais de experimentação e em humanos, uma miopatia caracterizada por degeneração de células musculares, comprometendo sobretudo a musculatura respiratória. Baseado no fato de que este comprometimento contribui para a piora da função respiratória, propõe-se um protocolo de avaliação rotineira de miotoxicidade por compostos organofosforados, através de uma bateria mínima e suficiente de colorações e reações histoquímicas para quantificação da necrose muscular. Utilizaram-se como modelo experimental, grupos de ratos albinos (Wistar) intoxicados com o organofosforado paraoxon, com e sem antídotos (atropina ou pralidoxima). Verificou-se nos grupos tratados com paraoxon e paraoxon mais atropina, necrose de fibras musculares no diafragma, que atingia em determinadas áreas até 15% das fibras. No grupo tratado com paraoxon mais pralidoxima, a necrose foi mínima, evidenciando o papel mioprotetor deste último antídoto.

APA, Harvard, Vancouver, ISO, and other styles

13

Lins, Liliane, Laís Gomes, Lis Gomes, et al. "Efeitos de baixas doses de radiação-X no desenvolvimento do sistema nervoso central: estudo experimental em ratos." Radiologia Brasileira 41, no. 1 (2008): 45–47. http://dx.doi.org/10.1590/s0100-39842008000100012.

Full text

Abstract:

OBJETIVO: Este trabalho analisa as conseqüências da irradiação-X no desenvolvimento do sistema nervoso de fetos de ratos. MATERIAIS E MÉTODOS: O trabalho foi constituído de 10 Rattus norvegicus albinos, Wistar, fêmeas, grávidas, com idade de oito semanas. Cinco ratas fêmeas constituíram o grupo controle e outras cinco tiveram suas regiões abdominais expostas por 30 segundos a uma dose de 0,3 Gy proveniente de um aparelho odontológico Gnatus de 70 kV e 10 mA. No 17º dia gestacional, ambos os grupos foram submetidos a histerectomia. As seções selecionadas foram examinadas para análise cerebral comparativa entre os grupos. RESULTADOS: O exame clínico revelou não haver diferenças morfológicas entre os grupos controle e experimental e nenhum dos animais apresentou anormalidades grosseiras. Vinte e sete por cento dos animais do grupo experimental apresentaram hemorragia cerebral moderada e 73% apresentaram hemorragia severa e danos no tecido nervoso. Nenhum animal do grupo controle apresentou hemorragia cerebral ou danificações de tecido nervoso. CONCLUSÃO: Estas evidências demonstram que pequenas doses de radiação-X podem causar hemorragias cerebrais e, conseqüentemente, lesão tecidual nervosa.

APA, Harvard, Vancouver, ISO, and other styles

14

Peters, Swaantje, Thomas Lamah, Despina Kokkinou, Karl-Ulrich Bartz-Schmidt, and Ulrich Schraermeyer. "Melanin Protects Choroidal Blood Vessels against Light Toxicity." Zeitschrift für Naturforschung C 61, no. 5-6 (2006): 427–33. http://dx.doi.org/10.1515/znc-2006-5-620.

Full text

Abstract:

Low ocular pigmentation and high long-term exposure to bright light are believed to increase the risk of developing age-related macular degeneration (ARMD). To investigate the role of pigmentation during bright light exposure, cell damage in retinae and choroids of pigmented and non-pigmented rats were compared. Pigmented Long Evans (LE) rats and non-pigmented (albino) Wistar rats were exposed to high intensity visible light from a cold light source with 140,000 lux for 30 min. Control animals of both strains were not irradiated. The animals had their pupils dilated to prevent light absorbance by iris pigmentation. 22 h after irradiation, the rats were sacrificed and their eyes enucleated. Posterior segments, containing retina and choroid, were prepared for light and electron microscopy. Twenty different sections of specified and equal areas were examined in every eye. In albino rats severe retinal damage was observed after light exposure, rod outer segments (ROS) were shortened and the thickness of the outer nuclear layer (ONL) was significantly diminished. Choriocapillaris blood vessels were obstructed. In wide areas the retinal pigment epithelium (RPE) was absent in albino rats after irradiation. In contrast, LE rats presented much less cell damage in the RPE and retina after bright light exposure, although intra-individual differences were observed. The thickness of the ONL was almost unchanged compared to controls. ROS were shortened in LE rats, but the effect was considerably less than that seen in the albinos. Only minimal changes were found in choroidal blood vessels of pigmented rats. The RPE showed certain toxic damage, but cells were not destroyed as in the non-pigmented animals. The number of melanin granules in the RPE of LE rats was reduced after irradiation. Ocular melanin protects the retina and choroid of pigmented eyes against light-induced cell toxicity. Physical protection of iris melanin, as possible in eyes with non-dilated pupils, does not seem to play a major role in our setup. Biochemical mechanisms, like reducing oxidative intracellular stress, are more likely to be responsible for melanin-related light protection in eyes with dilated lens aperture.

APA, Harvard, Vancouver, ISO, and other styles

15

DJAHRA, Ali Boutlelis, Mounia BENKADDOUR, Salah BENKHERARA, and Bordjiba OUAHIBA. "Antioxidant and hepatoprotective Potential of Coriandrum sativum L. against hepatic injury by Lambda-cyhalothrin insecticide." Journal of Drug Delivery and Therapeutics 10, no. 3-s (2020): 182–88. http://dx.doi.org/10.22270/jddt.v10i3-s.4186.

Full text

Abstract:

The objective of this study is to evaluate the antioxidant and hepatoprotective activity of aerial part and seeds of Coriandrum sativum plant against Lambda cyhalothrin insecticide. Male Wistar Albinos rats were randomly divided into control, LCT, CsA, CsS, CsS+LCT, CsA+LCT groups, after 90 days of treatments Biochemical, some oxidative stress parameters, and histopathology of liver tissue were evaluated. Total polyphenol content in aerial part and the seed extract estimated at 9.29 and 14.64 mg EAG / mg of extract and IC50 for an antioxidant activity equal to 19.38 and 22.62 mg/ml respectively. The obtained results revealed that rats received Lambda cyhalothrin insecticide showed a significant change in enzymes activity (AST, ALT, ALP and c-GT) and Glutathione (GSH) in liver. Meanwhile content of hepatic Malondialdehyde (MDA). Histopathology examination of liver revealed that Coriandrum sativum attenuate the incidence of liver lesions triggered by Lambda cyhalothrin intoxication. Therefore, the results of this study show that Coriandrum sativum can be proposed to protect the liver against Lambda cyhalothrin induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenging effect. Keywords: hepatoprotective, antioxidant, Coriandrum sativum L., Lambda cyhalothrin, Oxidative stress.

APA, Harvard, Vancouver, ISO, and other styles

16

Ikeme, M. M., and A. O. Adelaja. "Effet du moment de la stimulation antigénique sur le déroulement de la parasitémie et immunodépression consécutive lors d’une infection expérimentale à Trypanosoma brucei." Revue d’élevage et de médecine vétérinaire des pays tropicaux 43, no. 3 (1990): 331–36. http://dx.doi.org/10.19182/remvt.8806.

Full text

Abstract:

L'influence de l'administration de globules rouges de mouton comme antigène, avant ou après l'exposition trypanosomienne, sur le profil parasitémique et la réponse immunitaire de rats albinos Wistar est étudiée. Des taux élevés de parasitémie, en association avec une diminution significative des anticorps et de la valeur de l'hématocrite (PCV), ont été observés lorsque l'infection trypanosomienne a précédé la stimulation antigénique. A l'inverse, un net retard a été observé dans l'apparition et le développemen t de la parasitémie quand l'imprégnation antigénique précédait l'infection. Au début, les valeurs de l'hématocrite et la réponse immunitaire à l'antigène ont soutenu favorablement la comparaison avec les taux décelés sur les rats témoins; mais, au cours de l'infection, la parasitémie a augmenté et une réponse de type hypoimmunitaire est apparue. Avec le temps, elle a rejoint les taux trouvés chez les rats qui avaient été touchés par l'infecti on trypanosomienne avant la stimulation antigénique. Les auteurs suggèrent que de tels résultats soient retenus lors de l'évaluation des tests sérologiqu es pour mettre en évidence les réponses à des vaccinations spécifiques ou pour le diagnostic d'infections basé sur l'élévation des titres d'anticorps chez l'hôte

APA, Harvard, Vancouver, ISO, and other styles

17

Petroianu, Andy, Carlos Roberto Messeder Esquerdo, Alfredo José Afonso Barbosa, and Luiz Ronaldo Alberti. "Regeneração hepática induzida por ressecção segmentar do fígado, em rato." Revista do Colégio Brasileiro de Cirurgiões 31, no. 1 (2004): 10–14. http://dx.doi.org/10.1590/s0100-69912004000100003.

Full text

Abstract:

OBJETIVO: Avaliar a regeneração progressiva do parênquima hepatocitário, nos seus aspectos macro e microscópicos, em pós-operatório imediato e tardio de ressecção segmentar do fígado. MÉTODO: Foram estudados 10 ratos machos albinos da raça Wistar, pesando entre 250 e 300 gramas, submetidos à hepatectomia parcial de lobo esquerdo, com retirada de cerca de 20% da massa total do órgão. Os animais foram divididos aleatoriamente em dois grupos (n=5) para estudo no 7º (Grupo 1) e 21º (Grupo 2) dias pós-operatórios. Decorrido o tempo de acompanhamento, avaliou-se o aspecto macroscópico e microscópico do fígado. RESULTADOS: No Grupo 1, após sete dias, os animais apresentavam a cavidade abdominal com poucas aderências. O fígado mostrava reação cicatricial no local da ressecção, porém seu tamanho já era próximo ao normal. O exame histopatológico mostrou freqüentes sinais de poliploidia dos hepatócitos, além de tecido de granulação frouxo e desordenado, acompanhado de escasso infiltrado de células inflamatórias. O Grupo 2, após 21 dias, mostrava poucas aderências na cavidade abdominal, e o fígado com aspecto e dimensões próximos ao normal. A histologia mostrou tecido cicatricial mais denso, ordenado, sem sinais inflamatórios. Observou-se apenas pequeno grau de poliploidia hepatocitária. CONCLUSÃO: Após remoção cirúrgica de 20% do parênquima hepático houve aumento temporário da renovação celular verificado por poliploidia hepatocitária.

APA, Harvard, Vancouver, ISO, and other styles

18

Merouani, Nawel, and Rachid Belhattab. "Acute toxicity of Aristolochia longa L. of aqueous extract in mice." Journal of Drug Delivery and Therapeutics 10, no. 3 (2020): 4–10. http://dx.doi.org/10.22270/jddt.v10i3.4055.

Full text

Abstract:

Aristolochia longa L. (Aristolochiaceae) is widely used to treat breast cancer in Algerian traditional medicine. The present study was conducted to investigate the effects of ingestion of aqueous extracts of different parts of the plant on liver and kidney functions in wistar albinos mice. Acute oral toxicity was performed to determine DL50, this toxicity was carried out by the oral administration in single doses of 0–12 g/kg for tubers aqueous extracts and 2 g/kg and 5 g/kg for aerial and fruit aqueous extract respectively. General behavior, adverse effects and mortality were determined for up to 14 days. The animals were sacrificed and biochemical study was done. The acute oral toxicity result revealed that LD50 of the tubers and fruit aqueous extracts was respectively more than 12 g/kg and 5 g/kg, but DL50 of the aerial aqueous extract was at 5 g/kg. The result revealed also that liver and kidney function of different groups receiving high doses was affected as ASAT, ALAT, Urea, creatinine was significantly increased as compared to control group. Histological examination showed alterations of the renal parenchyma and the liver which is greater in animals treated with high dose. Thus, caution should be exercised with its usage. Keywords: Acute toxicity, Biochemical parameters, Histological examination Aristolochia longa L.

APA, Harvard, Vancouver, ISO, and other styles

19

Correa, Bárbara Soares, Carolina Aparecida Campanini, Laís Cristina Monteiro Paiva, Ramiro Nunes Da Silva, Wilson Roberto Malfará, and Ana Rosa Crisci. "Avaliação da Função Renal e Alterações Morfológicas em Ratos Tratados com Dipirona em Diferentes Doses." Journal of Health Sciences 18, no. 1 (2016): 32. http://dx.doi.org/10.17921/2447-8938.2016v18n1p32-36.

Full text

Abstract:

<p>A dipirona é um fármaco muito utilizado para o tratamento da febre e da dor, entretanto, seus efeitos em doses altas podem levar a danos irreversíveis e até letais. Na presente investigação foram utilizados 32 ratos albinos machos da linhagem Wistar. Um grupo (1) recebeu uma dose única, 5.000 mg/Kg de dipirona por gavagem e o outro grupo (2) administração uma vez ao dia, por quatro dias consecutivos, de 600mg/Kg de dipirona. Ao final de quatro dias, para o grupo 2 e após 3 horas de ingestão do medicamento para o grupo 1, os animais foram eutanasiados em câmara de CO2, conforme a aprovação do Comitê de Ética Animal do Centro Universitário Barão de Mauá (CEPAn). Foram avaliados os parâmetros ureia e creatinina e a histopatologia renal. Os resultados dos escores hemorragia glomerular, congestão renal e processo inflamatório foram estatisticamente significativos nos três parâmetros analisados para dose única; congestão renal e processo inflamatório para dose múltipla. O marcador de função renal, ureia apresentou diferença estatística significativa com a dose única. Os resultados do modelo experimental atestam que a metodologia aplicada foi capaz de demonstrar as alterações histopatológicas do grupo tratado com dipirona dose única assim como alterações na dosagem de ureia e a preservação das características normais do grupo controle. O mesmo não ocorreu com o grupo tratado com doses múltiplas.<strong></strong></p>

APA, Harvard, Vancouver, ISO, and other styles

20

Albas, C. S., J. P. Souza, G. A. Nai, and J. L. S. Parizi. "Avaliação da genotoxicidade da Ilex paraguariensis (erva mate) pelo teste do micronúcleo." Revista Brasileira de Plantas Medicinais 16, no. 2 suppl 1 (2014): 345–49. http://dx.doi.org/10.1590/1983-084x/12_058.

Full text

Abstract:

A Ilex paraguariensis é espécie nativa da América do Sul. O consumo de erva mate tem sido associado ao aumento nas taxas de câncer oral, de orofaringe, esôfago e laringe. O objetivo deste estudo foi investigar o potencial genotóxico da exposição a dose única de Ilex paraguariensis através do teste do micronúcleo. Para este estudo, foram utilizados 32 ratos Wistar albinos machos e adultos, divididos em 4 grupos: A - Composto por 8 ratos que receberam infusão de chá preparado na concentração de 5% de erva mate (concentração usualmente encontrada no chá de consumo humano); B - Composto por 8 ratos que receberam chá preparado por imersão em água fria na concentração de 5% de erva mate; C - Composto por 8 ratos, os quais receberam ciclofosfamida em dose única subcutânea (50mg/kg) no primeiro dia do experimento (grupo controle positivo); D - Composto por 8 ratos, os quais receberam somente água (grupo controle negativo). Todos os animais receberam ração ad libitum. Os animais dos grupos A, B e D foram submetidos à eutanásia 48 horas após o início do experimento e os do grupo C, 24 horas após. Foi coletado material da medula óssea de cada rato após a eutanásia para realização do teste do micronúcleo em eritrócito policromático, para avaliação do grau de genotoxicidade. A mediana de micronúcleos para o grupo A (chá mate preparado com infusão) foi de 0,00, do grupo B (chá mate em imersão em água fria) foi de 0,00, do grupo C (ciclofosfamida - controle positivo) foi de 9,00, e no grupo D (controle negativo) foi de 0,00. Não se observou genotoxicidade da Ilex paraguariensis, em ambas as formas de preparo do chá, através do teste de micronúcleo, ao nível de significância de 5%.

APA, Harvard, Vancouver, ISO, and other styles

21

Neves, Lindalva Batista, Regina Maria Catarino, Maria Regina Regis Silva, and Edison Roberto Parise. "Elevação dos níveis séricos de laminina na cirrose hepática induzida pelo tetracloreto de carbono." Arquivos de Gastroenterologia 40, no. 3 (2003): 173–76. http://dx.doi.org/10.1590/s0004-28032003000300007.

Full text

Abstract:

RACIONAL: Laminina sérica tem sido correlacionada com a hipertensão portal e a capilarização dos sinusóides na doença hepática crônica. Pouco é conhecido sobre sua dinâmica nas doenças hepáticas. OBJETIVO: Estudar os níveis séricos de laminina e correlacioná-los com graus de fibrose hepática e hipertensão portal em ratos tratados com tetracloreto de carbono. MATERIAL E MÉTODO: Quarenta e nove ratos albinos Wistar foram mantidos como controles (n = 16) ou tratados com solução de tetracloreto de carbono a 8% (n = 23). Entre a 6ª e 16ª semana de experimento animais foram sacrificados após cateterização da veia porta e medida da pressão portal. Fragmentos de fígado foram fixados em formol para microscopia óptica. A fibrose hepática foi classificada em perivenular, septal incompleta e completa e cirrose. Concentração de laminina circulante foi determinada pela técnica de ensaio imunoenzimático com anticorpo desenvolvido a partir de laminina isolada de tumor Engelbreth-Holm-Swarm e purificado em coluna de afinidade. RESULTADOS: A pressão portal correlacionou-se com grau de fibrose hepática (r = 0,82; n = 45) e seus níveis nos grupos fibrose septal (10,8 ± 1,2 cm H2O) e cirrose (13,6 + 3,1 cm H2O) foram estatisticamente superiores aos observados no grupo-controle (7,9 + 1,5 cmH2O) e no grupo com fibrose perivenular (9,1 + 0,8 cmH2O). A concentração de laminina no sangue periférico dos cirróticos (40,0 + 18,7 µg/dL) foi significativamente superior aos grupos-controle (13,8 + 12,1 µg/dL), fibrose perivenular (19,1 + 15,5) e fibrose septal (22,2 + 27,0 µg/dL). Laminina circulante correlacionou-se de maneira significativa com o grau de fibrose hepática (r = 0,59; n = 49) e com os níveis de pressão portal (r = 0,29; n = 45). CONCLUSÕES: Na intoxicação crônica experimental pelo tetracloreto de carbono, níveis circulantes de laminina correlacionam-se mais com o grau de fibrose hepática do que com os níveis de hipertensão portal.

APA, Harvard, Vancouver, ISO, and other styles

22

Ghori, Syed Safiullah, Tahreen Shazia Siddiqua, and Anees Fathima. "Nephroprotective Effect of Ficus Dalhousiae Miq Leaf Methanolic Extract in Albino Wistar Rats." International Journal of Pharma Research and Health Sciences 4, no. 5 (2016): 1394–98. http://dx.doi.org/10.21276/ijprhs.2016.05.10.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

G, Yadav, Awasthi J R, Pandey N, Shrestha S, and Jha CB. "EFFECT OF VITAMIN E AGAINST HEAT STRESS INDUCED TESTICULAR DAMAGE IN WISTAR ALBINO RATS." International Journal of Anatomy and Research 5, no. 2.2 (2017): 3800–3804. http://dx.doi.org/10.16965/ijar.2017.184.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

AYDIN, Barbaros, Deniz YALMAN, Başak DOĞANAVŞARGİL, Serra KAMER, and Hülya ELLİDOKUZ. "Structural Changes in the Intestinal Mucosa of Wistar-Albino Rats After Irradiation, and Protective Effect of Ascorbic Acid." Turkiye Klinikleri Journal of Medical Sciences 34, no. 3 (2014): 298–306. http://dx.doi.org/10.5336/medsci.2013-35421.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Singh, Rajbala, Ruqaiyah Khan, Deepak Tiwari, Heman Heman, Rajbir Singh, and Firoz Anwar. "Pharmacological and biochemical assessment of Talc on Doxorubicin induced cardiac remodelling in albino Wistar rats." Asian Pacific Journal of Health Sciences 3, no. 1 (2016): 44–52. http://dx.doi.org/10.21276/apjhs.2016.3.1.8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

K., Ahmed S., Chakrapani Cheekavolu, Sampath D., and Sunil M. "Evaluation of antidiabetic activity of fruit of Coriandrum sativum. Linn methanolic extract in Streptozocin induced diabetic wistar Albino rats." International Journal of Basic & Clinical Pharmacology 7, no. 1 (2017): 121. http://dx.doi.org/10.18203/2319-2003.ijbcp20175686.

Full text

Abstract:

Background: Diabetes prevalence is estimated to increase annually. Numerous people use traditional medicine, such as India also considered as the diabetic capital in the world. Diabetes is a metabolic disorder characterized by disturbances in lipid, carbohydrate and protein metabolism. The present study to evaluate the antidiabetic potential of coriandrum sativum. linn fruits methanolic extract in streptozocin induced diabetic wistar albino rats model.Methods: Diabetes induction in wistar albino rats by administration of streptozocin (50mg/kg, i.p.) in citrate buffer. 30 wistar albino rats were divided into 5 groups (A, B, C, D, E). Group A: served as normal control, whereas Group B: diabetic control, Group C, D methanolic coriandrum sativum Linn. fruits extract (CSFME) at a dose of 100, 200mg/kg orally, Group E was given standard drug Glibenclamide (0.5mg/kg) orally. All groups are administered for the period of 14 consecutive days and blood sugar levels was measured at regular intervals up to end of the study.Results: This present research study confirms that the test drug compound CSFME has sustained oral hypoglycaemic activity and statistically significant (p ≤0.05) and which is comparable with standard drug Glibenclamide.Conclusions: This research study confirms that the CSFME has antidiabetic activity against streptozocin induced wistar diabetic albino rats. It could be a novel antidiabetic agent and also a dietary adjunct in the type 2 diabetes management and its complication. Further studies are necessary required to confirm the antidiabetic activity of individual phytochemical compounds of Coriandrum sativum.

APA, Harvard, Vancouver, ISO, and other styles

27

Amalraj, JulieChristy, N. Charanya, Saraswathi Perumal, and V. Sathialakshmi. "Effect of Kenacort on pregnant Wistar albino rats." Annals of Maxillofacial Surgery 9, no. 2 (2019): 253. http://dx.doi.org/10.4103/ams.ams_141_16.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Kapgate, Sarita M., and Abhijit B. Patil. "STANDARDIZATION OF MODEL OF INDUCTION OF HEPATOTOXICITY WITH ANTI-TUBERCULOSIS DRUGS IN WISTAR ALBINO RATS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 6 (2017): 150. http://dx.doi.org/10.22159/ajpcr.2017.v10i6.11971.

Full text

Abstract:

Objective: The objective of the study to standardize the model of hepatotoxicity induced by ATT drugs in Wistar Albino rats. Isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA), the first line drugs used in the treatment of tuberculosis (TB) associated with the potential adverse effect. Numerous animal studies were reported endeavoring induction and cure of anti-TB (ATT) drug-induced hepatotoxicity using herbal and chemical drugs. However, the previous reported study failed to replicate where Wistar albino rats were treated with INH, RMP, and PZA and had shown the significant development of liver injury. Hence in present paper, aimed to develop a standardize model of induction of hepatotoxicity with ATT drugs.Methods: Wistar rats were treated with ATT drugs in combination in various doses up to 4-8 weeks. Total nine experiments were conducted to achieve successful hepatotoxicity. The aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were the biochemical parameters of assessment. Histopathological changes in the liver were also examined.Results: No evidence of any liver injury or an inflammatory infiltrate has been observed as had been reported in the previous studies. Rather decrease in serum ALT levels has been observed by researcher. In short, hepatic injury cannot be developed with the doses used in previous reported papers. The successful attempt to induce hepatotoxicity can be achieved with the doses of INH - 100, RMP - 300, PZA - 700 mg/kg. The findings were confirmed by the raised ALT, AST, and ALP levels compared with baseline. The histopathological changes also support the findings.Conclusion: The dose of INH - 100, RMP – 300 and PZM - 700 mg/kg. Succeeds to induce hepatotoxicity in Wistar albino rats and Swiss albino mice as well.

APA, Harvard, Vancouver, ISO, and other styles

29

T, Siva Kumar, Shobha Rani A, Sujatha K, Purushotham B, and Neeraja P. "TOXICITY EVALUATION OF AMMONIUM SULFATE TO ALBINO RAT." Asian Journal of Pharmaceutical and Clinical Research 10, no. 1 (2016): 313. http://dx.doi.org/10.22159/ajpcr.2017.v10i1.15355.

Full text

Abstract:

ABSTRACTObjective: The present study was designed to find out the acute median lethal dose (LD50) of ammonium sulfate (inorganic fertilizer) in Wister albino rats.Methods: A single dose of ammonium sulfate dissolved in distilled water (Milli-Q) and administered intraperitoneally at concentrations of 10, 30, 50,70, 90, 110, 130, and 170 mg/kg body weight, respectively, to experimental animals, and then, they were observed every 3 hrs from prior dose giventime, later 6 hrs, 12 hrs, 24 hrs, to 48 hrs of noticing any abnormal behaviors and toxic signs, symptoms. After 48 hrs, counted the number of ratsdeparted in each group and mortality percentage was calculated.Results: The obtained results were evaluated by the Statistical Probit Analysis Method and 48 hrs LD value for albino rats was found tobe 91.5 mg/kg. At a single dose of 10 mg/kg, there is no morality and toxic behaviors were observed. Therefore, this concentration is considered asno observed adverse effect level dose.Conclusion: From the earlier consequences, identification and evaluation of the LD5050 against ammonium sulfate is crucial for understanding thehyperammonemia because ammonium sulfate has been highly utilized as inorganic fertilizer in agriculture and household gardens. Thus, theknowledge about toxic impacts of ammonia useful for clinical or toxicological approaches; however, the toxicity data are unclear. Hence, the in vitroLD50 evaluations of target chemical in Wistar rats is highly associated toward in ammonia-related peculiar disorders perceptive and therapy.Keywords: Ammonium sulfate, Fertilizer, Median lethal dose, Mortality, No observed adverse effect level.

APA, Harvard, Vancouver, ISO, and other styles

30

Awoyinka, Olayinka Anthony, Tola Racheal Omodara, Funmilola Comfort Oladele, et al. "Gut Microbiota Hypolipidemic Modulating Role in Diabetic Rats Fed with Fermented Parkia biglobosa (Fabaceae) Seeds." RADS Journal of Biological Research & Applied Sciences 11, no. 2 (2021): 89–97. http://dx.doi.org/10.37962/jbas.v11i2.332.

Full text

Abstract:

Background: Modulation and balancing of host gut microbiota by probiotics has been documented by several literature. Prebiotic diets such as locust beans have been known to encourage the occurrence of these beneficial microorganisms in the host gut. Objectives: To study the modulating role of gut microbiota in the hypolipidemic effect of fermented locust beans on diabetic Albino Wister rats as animal models. Methodology: Albino rats (Wistar strain), averagely weighing 125g were successfully induced with alloxan. Thereafter this induction, anti-diabetic treatment was carried out on various groups of rats by feeding them ad-libitum with a diet of milled fermented and unfermented Parkia biglobosa seeds, respectively. Results: After three weeks of treatment, it was observed that fermented locust beans caused a significant reduction (p ≤ 0.05) in glucose, total triglycerides, total cholesterol and LDL, while the HDL levels were significantly elevated (p ≤ 0.05). Results of faecal analysis showed that the fermented locust beans modulated the gut microbiota through the occurrence of probiotic bacteria, Bacillus subtilis in the gut and faeces of the rats. Conclusion: This study support that fermented locust beans is a prebiotic diet that encourages the growth of Bacillus subtilis in the gut of animals and is associated with hypolipidemic activities which alleviate diabetes as portrayed in these rat models.

APA, Harvard, Vancouver, ISO, and other styles

31

Gautam, Swetlana, Priyanka Singh, Manjari Singh, et al. "Rifaximin, a pregnane X receptor (PXR) activator regulates apoptosis in a murine model of breast cancer." RSC Advances 8, no. 7 (2018): 3512–21. http://dx.doi.org/10.1039/c7ra09689e.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Wardani, Giftania, Mahmiah Mahmiah M, and Sri Agus Sudjarwo. "Immunostimulatory Activity of Chitosan Nanoparticles on Wistar Albino Rats." Pharmacognosy Journal 10, no. 5 (2018): 892–98. http://dx.doi.org/10.5530/pj.2018.5.150.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Sadanandan, Neethu N., Archana R, Sai Sailesh Kumar, Mukkadan J K, and Antony N J. "ANTIHYPERLIPIDEMIC EFFECT OF VESTIBULAR STIMULATION IN WISTAR ALBINO RATS." International Journal of Research in Ayurveda and Pharmacy 6, no. 4 (2015): 509–12. http://dx.doi.org/10.7897/2277-4343.06496.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Choudhary, Arbind Kumar, Lognatahan Sundareswaran, and Rathinasamy Sheela Devi. "Aspartame induced cardiac oxidative stress in Wistar albino rats." Nutrition Clinique et Métabolisme 30, no. 1 (2016): 29–37. http://dx.doi.org/10.1016/j.nupar.2016.01.071.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Abuelgasim, Afaf I., Rehab Omer, and B. Elmahdi. "Serrobiochemical Effects of Potassium Bromate on Wistar Albino Rats." American Journal of Food Technology 3, no. 5 (2008): 303–9. http://dx.doi.org/10.3923/ajft.2008.303.309.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Psilovikos. "Erythropoietin-Like Effects of Dihydroartemisinin in Wistar Albino Rats." American Journal of Agricultural and Biological Sciences 6, no. 4 (2011): 511–16. http://dx.doi.org/10.3844/ajabssp.2011.511.516.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

P, Uma Maheswari, Shalimol A, Arumugasamy A, and Udhaya Sankar M.R. "EVALUATION OF WOUND HEALING ACTIVITY OF METHANOLIC EXTRACT OF SMILAX WIGHTII (A. DC.) IN WISTAR ALBINO RATS." Kongunadu Research Journal 1, no. 1 (2014): 73–77. http://dx.doi.org/10.26524/kr17.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

TK, Hafis, Shyamjith Manikkoth, Melinda Sequeira, and Roopa P. Nayak. "Pharmacological evidence for the anticonvulsant activity of Tylophora indica in experimental animal models." International Journal of Basic & Clinical Pharmacology 6, no. 4 (2017): 750. http://dx.doi.org/10.18203/2319-2003.ijbcp20171029.

Full text

Abstract:

Background: Epilepsy is a common neurological disorder. The antiepileptic drugs currently used are unable to manage seizures effectively and are associated with numerous adverse drug effects. Hence, there is a necessity of a newer anticonvulsant drug with high therapeutic index profile. The objective of this pre-clinical research was to investigate the role of Tylophora indica on Maximal electric shock [MES] and Pentylene tetrazole [PTZ] provoked convulsions in Wistar albino rats.Methods: 36 Wistar albino rats were used for this study, after obtaining ethical clearance. The ethanolic extract of the leaves of Tylophora indica [TIEE] (100 mg/kg, p.o) was used to screen the anticonvulsant effect on MES and PTZ provoked convulsions in Wistar albino rats. In MES seizures, inhibition of the tonic hind limb extension and in PTZ seizures, extent of convulsions was noted.Results: TIEE (100 mg/kg, p.o) significantly (p<0.001) blocked the hind limb extension due to MES. The same dose also significantly (p<0.001) lessened the extent of convulsions induced by PTZ.Conclusions: The data suggests that the ethanolic extract of Tylophora indica leaves produce its anticonvulsant effect via different mechanisms since it prevented the hind limb extension induced by MES and decreased the duration of convulsions produced by PTZ.

APA, Harvard, Vancouver, ISO, and other styles

39

K, Sujeethasai, Manoharan A та Santhanakumar M. "Anti-Hypertensive Activity of Hydro Alcoholic Extract of Cìraka Cūraṇam on High Salt Loaded Wistar Albino Rats". International Journal of Research and Review 8, № 5 (2021): 110–15. http://dx.doi.org/10.52403/ijrr.20210516.

Full text

Abstract:

Background: Hypertension is called as Silent killer. The most important risk factor for heart diseases and stroke and it may leads to premature death. Several medicinal plants have high effective in anti-hypertensive and anti-thrombotic activity without any side effects. Aim: To evaluate the anti-hypertensive activity of hydro alcoholic extract of Cìraka cūraṇam on deoxycorticosterone acetate (DOCA) salt induced wistar albino rats. Study design: Observational in-vivo study Place and duration of study: Animal house, Dept. of Pharmacology, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Srivilliputtur,Tamilnadu. Materials and methods: Antihypertensive activity was conducted on wistar albino rats by determining serum Sodium and Potassium levels by using semi auto analyzer (RA-50, Bayer Diagnostics), using specific kits (Auto span, India) at 500 and 550 nm respectively and left carotid artery (for recording BP) was cannulated under aseptic conditions with polyethylene cannula filled with 1% heparin in normal saline. Rest procedure, which was stated under the 2K1C-model was followed and BP was observed in terms of mm of Hg. Results: The Cìraka cūraṇam possesses strong antihypertensive effect against DOCA-salt hypertensive rats, which is evidenced by a considerable decrease in blood pressures. Keywords: Anti-hypertensive activity, Cìraka cūraṇam, Wistar albino rats, Deoxycorticosterone acetate.

APA, Harvard, Vancouver, ISO, and other styles

40

Tanwar, Beenu, Rajni Modgil, and Ankit Goyal. "Antinutritional factors and hypocholesterolemic effect of wild apricot kernel (Prunus armeniacaL.) as affected by detoxification." Food & Function 9, no. 4 (2018): 2121–35. http://dx.doi.org/10.1039/c8fo00044a.

Full text

Abstract:

Detoxification treatment substantially reduced antinutritional factors along with the complete removal of hydrocyanic acid from wild (bitter) apricot kernel and improved the hypocholesterolemic effect in male Wistar albino rats.

APA, Harvard, Vancouver, ISO, and other styles

41

Putri, Tetra Anestasia. "PENGARUH PEMBERIAN BISPENOL-A (BPA) TERHADAP JUMLAH SPERMATOZOA PADA Rattus norvegicus GALUR WISTAR ALBINO." JURNAL KESEHATAN PERINTIS (Perintis's Health Journal) 6, no. 1 (2019): 9–13. http://dx.doi.org/10.33653/jkp.v6i1.210.

Full text

Abstract:

Bispenol-a (BPA) has an esterogen hormone activity while it enters the body, it can become endocrine disruptor. The objetive of this study was to purpose to prove that bispenol a can decrease spermatozoa cell count in male wistar albino strain rats (rattus novergicus).This research is an experimental design with post-only control group by using 20 male wistar albino strain rats (rattus Novergicus). Those sample aged 2-3 months which divided into four groups for 5 rats each. Control group (K) without bispenol-a adduction. The first (P1), second (P2), and third (P3) group treatment was given with BPA in 51 days for 0.45, 0.9 and 1.8 mg/body weight(kgs)/day for a 51-day. After 51-day treatment.This research showed that mean value of testosterone hormone for control group was 7.78 ng/lts. P1 group, P2 and P3 groups showed 6.19, 5.23 and 4.02 ng/lt.the count of spermatozoa has mean value for control group was 39,1 while first group (P1) was 30.2 . In second (P2) and third (P3) treatment group were 21,1 and 19.7. Data analysis showed mice spermatozoa cell count had p <0.05, which means that there is significance differentiation between control and treatment groups.It can be concluded that there is an effect of bisphenol a adduction on male Rattus novergicus wistar albino strain spermatozoa cell count.

APA, Harvard, Vancouver, ISO, and other styles

42

Blaszczyk, Wanda M., Larissa Arning, Klaus-Peter Hoffmann, and Joerg T. Epplen. "ATyrosinasemissense mutation causes albinism in the Wistar rat." Pigment Cell Research 18, no. 2 (2005): 144–45. http://dx.doi.org/10.1111/j.1600-0749.2005.00227.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

CHUKWUNELO, Alpha C., Assumpta C. ANOSIKE, Emmanuel I. NNAMONU, Daniel E. EKPO, Prince O. JAMES, and Tochukwu I. OKONKWO. "Evaluation of Leukocyte Mobilization and Platelet Aggregatory Effects of Ciprofloxacin, Lincomycin and Erythromycin in Wistar Albino Rats." Notulae Scientia Biologicae 11, no. 4 (2019): 345–51. http://dx.doi.org/10.15835/nsb11410491.

Full text

Abstract:

This study evaluated leucocyte mobilization and platelet aggregation effects of ciprofloxacin, lincomycin and Erythromycin in Wistar albino rats. Thirty-three female Wistar albino rats weighing 130-160 g and three male Wistar albino rats weighing 188-194 g, fed commercial growers’ mash and clean tap water were used. In leukocytes assay, thirty-three adult female Wistar rats were assigned into five treatments, eleven groups of three rats per group. First three groups were treated 10 mg kg-1, 20 mg kg-1 and 40 mg kg-1 of ciprofloxacin, next three groups same doses of lincomycin, next three groups same doses of Erythromycin, the tenth group received Indomethacin 5 mg kg-1 (reference drug), the last group 5 mg kg-1 normal saline. Assay on platelet aggregator activity involved collection of blood samples (10 ml each, 1% EDTA, centrifuged at 3000 rpm for 10 minutes), test drugs dissolved in 1 mg/ml distilled water and Indomethacin (the reference drug). The three antibiotics significantly reduced leucocyte mobilization into the affected tissue. They all had their maximum inhibitory effects at the highest dose (40 mg kg-1) compared with indomethacin. Erythromycin 40 mg kg-1 showed the highest inhibitory effect on leucocyte migration. Whereas ciprofloxacin and erythromycin had stepwise increase in absorbance from time 0 secs through to time 120 secs, lincomycin showed a sharp decrease in the absorbance at around 30 seconds followed by a continuous increase up to 120 seconds. The testing drugs prevented leukocyte mobilization also had stepwise increase in absorbance from time 0 secs through to time 120 secs in platelet aggregatory activity assay to some extent.

APA, Harvard, Vancouver, ISO, and other styles

44

De Russi, Brenno Marco, and Camila Albuquerque Melo Carvalho. "Anatomic and Embryological Aspects of the Cardiovascular System of Albino Wistar Rats." Journal of Morphological Sciences 36, no. 04 (2019): 317–20. http://dx.doi.org/10.1055/s-0039-1697008.

Full text

Abstract:

AbstractThe Wistar albino rat is the animal most commonly used in scientific research around the world. Knowledge of the anatomy of the body of these animals is key in the research field, especially in cases when the research requires experimental surgery. Descriptive literature on the morphology of the cardiovascular system of these animals, particularly the heart, is old and difficult to access. Publications in journals are not readily available, and books approach the subject in a superficial way. The aim of this study is to research, organize, and translate the literature on the anatomy and embryology of the cardiovascular system of the albino Wistar rat to facilitate the use of this information in future research that requires the knowledge of the anatomy of these animals, for example, experimental surgery research.

APA, Harvard, Vancouver, ISO, and other styles

45

Chowta, MuktaN, Rakshita Maskeri, Amrita Rai, Ahasan Shoeb, V. Venkatesh, and Vani Bhagwat. "Evaluation of anxiolytic activity of vanillin in wistar albino rats." International Journal of Nutrition, Pharmacology, Neurological Diseases 3, no. 2 (2013): 96. http://dx.doi.org/10.4103/2231-0738.112828.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Arunagiri, Thilakavathi, Arjun Pandian, and Samiraj Ramesh. "Hypocholesterolemic Effect of Dietary Fish Oil in Albino Wistar Rats." Research Journal of Pharmacy and Technology 12, no. 9 (2019): 4161. http://dx.doi.org/10.5958/0974-360x.2019.00718.2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Chanda, Sumitra, Rajeshkumar Dave, Mital Kaneria, and Vinay Shukla. "Acute oral toxicity ofPolyalthia longifoliavar.pendulaleaf extract in Wistar albino rats." Pharmaceutical Biology 50, no. 11 (2012): 1408–15. http://dx.doi.org/10.3109/13880209.2012.682117.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Uchechukwu. "Respiratory Tract-Widening Effects of Dihydroartemisinin in Wistar Albino Rats." American Journal of Pharmacology and Toxicology 6, no. 2 (2011): 46–48. http://dx.doi.org/10.3844/ajptsp.2011.46.48.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

R, Kavitha, Kannan R, and Glory I. "Selected neurobehavioural evaluation of Leucas Aspera in wistar albino rats." International Journal of Basic & Clinical Pharmacology 2, no. 4 (2013): 433. http://dx.doi.org/10.5455/2319-2003.ijbcp20130817.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Ishola, AjibolaAbdulrahamon. "Exposure to aflatoxin and aggressive behavior among wistar albino rats." Journal of Neurobehavioral Sciences 7, no. 2 (2020): 72. http://dx.doi.org/10.4103/jnbs.jnbs_9_20.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'Albinos Wistar'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles