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Gibson, David J., Karen Hartery, Jayne Doherty, et al. "CRP/Albumin Ratio." Journal of Clinical Gastroenterology 52, no. 6 (2018): e48-e52. http://dx.doi.org/10.1097/mcg.0000000000000884.
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Radakovic, Sonja, Maja Surbatovic, Nebojsa Stankovic, and N. Filipovic. "Changes in concentrations of sera proteins in war wound." Acta chirurgica Iugoslavica 52, no. 1 (2005): 59–64. http://dx.doi.org/10.2298/aci0501059r.
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During the general reaction to trauma, substantional changes in protein composition of sera occur. The aim of the prospective study was to investigate net change in total protein and albumin concentrations, as well as albumin/ globulin ratio in sera of war casualties during the first 14 posttraumatic days, and to establish the correlation between these changes and severity of trauma. Subjects were 79 war casualties. Controls: 33 blood donors. Methods: Injury severity was determined according to ISS and blood samples were collected 12 hours after trauma, then on the 1st, 2nd, 5th and 14th posttraumatic day. In war casualties values of total protein and albumin concentrations and albumin/globulin ratio were significantly decreased. Minimal concentrations were measured on 2nd posttraumatic day (589.04 g/l for total proteins, p; 36.66.21 g/l for albumins, p) or on 5th day (0.860.2 for albumin/globulin ratio, p). Conclusions: During the acute-phase response to trauma, significant changes in concentration of total proteins, albumins and albumin/globulin ratio occur in sera of war casualties. These changes are the most prominent during the first 5 days, with tendency for normalization after that. Intensity of these changes depends of the severity of trauma.
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International, Journal of Medical Science and Advanced Clinical Research (IJMACR). "Assessment of Prognostic Value of Lactate/Albumin Ratio in Sepsis." International Journal of Medical Science and Advanced Clinical Research (IJMACR) 8, no. 2 (2025): 201–7. https://doi.org/10.5281/zenodo.15240633.
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<strong>Abstract</strong> <strong>Background: </strong>Sepsis is one of the leading causes of mortality and morbidity in intensive care units (ICUs) worldwide. Despite advances in medical care, the burden of sepsis remains significant, with high incidence and mortality rates reported globally and in India. Identification and prognostication of sepsis at an early stage is crucial for improving patient outcomes. <strong>Objectives: </strong>This study aims to assess the prognostic value of the lactate-to-albumin ratio (LAR) in patients with sepsis. <strong>Methodology: </strong>A prospective observational study was conducted over one year (2022-2023) involving 100 patients admitted with sepsis to the ICU of Gandhi Medical College and Hamidia Hospital, Bhopal. Serum lactate levels and serum albumin levels were recorded. The lactate-to-albumin ratio was calculated for each patient. Statistical analysis was performed using IBM SPSS version 20. ROC curve analysis was used to evaluate the optimal cut-off value for the lactate-to-albumin ratio in predicting in-hospital mortality. A p-value of less than 0.05 was considered statistically significant. <strong>Results:</strong> The results demonstrated a significant correlation between high lactate-to-albumin ratio and adverse sepsis outcomes. Patients with higher lactate-to-albumin ratio values had increased in-hospital mortality rates and longer ICU stays. <strong>Conclusion: </strong>The findings suggest that the lactate-to-albumin ratio is a robust prognostic marker that can aid in early risk stratification of sepsis patients, potentially guiding therapeutic decisions and improving clinical outcomes ultimately reducing its associated morbidity and mortality.
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Upadhyay, Anupma, and Meena Dayal. "Screening for preeclampsia by urine albumin to creatinine ratio." New Indian Journal of OBGYN 4, no. 2 (2018): 117–20. http://dx.doi.org/10.21276/obgyn.2018.4.2.5.
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MISHKIN, F. S., A. NIDEN, A. KUMAR, A. THOMAS, I. C. REESE, and P. VASINRAPEE. "Albumin Lung/Heart Ratio Change." Survey of Anesthesiology 31, no. 5 (1987): 312???313. http://dx.doi.org/10.1097/00132586-198710000-00055.
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Acikgoz, Yusuf, Oznur Bal, and Mutlu Dogan. "Albumin–to–Alkaline Phosphatase Ratio." Pancreas 50, no. 1 (2021): 111–17. http://dx.doi.org/10.1097/mpa.0000000000001720.
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Mishkin, Fred S. "Albumin Lung/Heart Ratio Change." JAMA 257, no. 7 (1987): 953. http://dx.doi.org/10.1001/jama.1987.03390070073026.
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Mohammad Nazri, Nor Amirah, Wan Norlina Wan Azman, Norsyuhadah Musa, et al. "C-reactive Protein, Albumin, Urea, CRP/Albumin Ratio, and Urea/Albumin Ratio: A Retrospective Evaluation in COVID-19 Patients." NOVEMBER 2023 19, no. 6 (2023): 164–70. http://dx.doi.org/10.47836/mjmhs.19.6.22.
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Introduction: C-reactive protein (CRP), urea, albumin, CRP/albumin ratio (CAR) and urea/albumin ratio (UAR) could be valuable biomarkers for determining the severity of illness in patients with COVID-19. This study aimed to determine the association between these markers and disease severity in COVID-19 patients on admission and days five to seven after admission. Methods: This retrospective study includes 153 adult COVID-19 patients admitted to Hospital Raja Perempuan Zainab II and Hospital Ampang from January 2021 to December 2021. Patients’ serum CRP, urea, albumin and creatinine levels were recorded on admission and on days five to seven after admission. The patients were categorised based on the Annex 2e guidelines published by the Ministry of Health, Malaysia and further classified as mild to moderate disease (stages 1-3) and severe to critical illness (stages 4-5). Results: On admission, urea, creatinine, CRP, UAR and CAR were significantly higher in the severe to critical group (p<0.001). The optimal cut-off value for the UAR was 0.16; the area under the curve (AUC) was 0.760, and sensitivity and specificity were 63.6% and 85.7%, respectively. The AUC of the CAR was 0.752, with 54.2% sensitivity and 91.4% specificity at an optimal cut-off value of 1.63. In severe to critical COVID-19 patients, albumin levels decreased significantly on days five to seven after admission, while urea levels remained significantly higher in this group (p<0.001, p<0.05, respectively). Conclusion: CRP, urea, albumin, CAR and UAR are promising biomarkers for predicting the severity of disease in COVID-19 patients.
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Harvey, J. N., K. Hood, J. K. Platts, S. Devarajoo, and P. A. Meadows. "Prediction of albumin excretion rate from albumin-to-creatinine ratio." Diabetes Care 22, no. 9 (1999): 1597–98. http://dx.doi.org/10.2337/diacare.22.9.1597.
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Cundy, T., and J. Baker. "Prediction of albumin excretion rate from albumin-to-creatinine ratio." Diabetes Care 23, no. 5 (2000): 714. http://dx.doi.org/10.2337/diacare.23.5.714b.
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Amira, Elsabagh Abdou, Abd-Elwahab Selim Heba, Mohamed Mohyeldin Amany, and Ahmed Hany Marwa. "C-Reactive Protein to Albumin Ratio and Albumin to Fibrinogen Ratio in Rheumatoid Arthritis Patients." Modern Rheumatology Journal 16, no. 2 (2022): 21–25. http://dx.doi.org/10.14412/1996-7012-2022-2-21-25.
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Objective: the albumin to fibrinogen ratio (AFR) and the C-reactive protein (CRP) to albumin ratio (CAR) have been proposed as markers of systemic inflammation. The goal of this study was to differentiate rheumatoid arthritis (RA) patients from healthy people and to study the association between AFR/CAR and DAS28 in RA.Patients and methods. A case control study including 30 RA patients and 30 healthy controls was performed. Fibrinogen, albumin, CRP and erythrocyte sedimentation rate (ESR) were measured. We calculated CAR and AFR in each group and compared them. Correlations of AFR, and CAR with disease activity were examined. Receiver operation characteristic (ROC) curves of AFR and CAR were also used to detect cutoffs for disease activity assessment.Results and discussion. CAR was higher while AFR was lower in RA patients than in control group. ROC curve analyses showed that CAR can be used to detect disease activity of RA at cut off 2.66 with sensitivity 81.3% and specificity 64.3% with an area under the curve (AUC) 0.78. So, CAR was a fair parameter to discriminate disease activity among RA patients. AFR has AUC 0.62, sensitivity 87.5% and specificity 42.9% at cutoff value 5.96. So, in our group AFR was a poor indicator to discriminate disease activity among RA patients.Conclusion. AFR and CAR have been recently proposed as inflammatory markers for assessment of disease activity in RA. AFR and CAR are simple, and inexpensive biomarkers, they also can be rapidly evaluated. CAR was found to be a fair parameter to depict disease activity in RA patients. AFR poorly depicted RA activity.
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Kato, Kenji, Tomoko Matsui та Sigeyuki Tanaka. "Quantitative Estimation of α-Helix Coil Content in Bovine Serum Albumin by Fourier Transform-Infrared Spectroscopy". Applied Spectroscopy 41, № 5 (1987): 861–65. http://dx.doi.org/10.1366/0003702874448049.
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Heat denaturation of albumin aqueous solution enables us to control the α-helix content to a reasonable level, and denatured albumin, whose conformation is different, can be obtained. Fourier transform-infrared absorption spectra in the amide I, II, and III band regions of these albumins have been measured and compared with each other. As a result, the characteristic frequencies associated with each conformation of α-helix, β-sheet, and random structure have been observed; moreover it has been newly proved that the intensity ratio of the amide II band to the amide I band depends on the α-helix content in albumin. In this paper, we demonstrate that this intensity ratio is very useful for quantitative estimation of α-helix content in albumin and apply this method to analysis of ATR spectra of albumin adsorbed on polyethylene surface.
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Ozdemir, Hasan Huseyin. "Analysis of the albumin level, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio in Guillain-Barré syndrome." Arquivos de Neuro-Psiquiatria 74, no. 9 (2016): 718–22. http://dx.doi.org/10.1590/0004-282x20160132.
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ABSTRACT The purpose of this study was to investigate the prognostic value of the pretreatment and post-treatment albumin level, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in subtypes of Guillain-Barré syndrome (GBS). A retrospective analysis of 62 patients with GBS treated between 2011 and 2015 in Dicle University Hospital, Turkey, was carried out. The pretreatment and post-treatment albumin, NLR, and PLR were documented, together with acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy, motor sensory axonal neuropathy, and Hughes’ scores. Post-treatment albumin levels in GBS were significantly reduced, and albumin level was negatively correlated with the Hughes scores. Elevated pretreatment NLRs and PLRs were significantly associated with AIDP. There were no correlations between the Hughes scores, NLR, and PLR. The results point to a negative correlation between albumin levels and GBS disability and suggest that the NLR and PLR may be promising blood biomarkers of AIDP.
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Sevcan, Ugur. "C-reactive protein to albumin ratio, albumin to globulin ratio and platelet to lymphocyte ratio in patients with spondyloarthritis." Turkish Journal of Health and Sport 3, no. 1 (2022): 1–4. https://doi.org/10.29228/tjhealthsport.55675.
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Aim: The C-reactive protein (CRP) to albumin ratio (CAR) has been reported as a novel inflammatory marker to assess inflammation. Serum globulin increases in inflammation. In this study, it was aimed to evaluate relation between CAR, albumin to globülin ratio (AGR), platelet to lymphocyte ratio (PLR) and disease activity in patients with axial spondyloarthritis (AxSpA). Method: Seventy-five patients with axial SpA and seventy-five healthy controls were evaluated retrospectively. CRP, albumin, globulin, leukocyte, lymphocyte, and platelet from the patients and controls were recorded. CAR, AGR and PLR were calculated. Disease activity was evaluated by the BASDAI and ASDAS. Results: The mean age was 38.2±10.39 years in patients with AxSpA and 35.45±8.96 years in controls. The CAR was 0.153±0.2 in AxSpA patients and 0.03±0.02 in controls (p<0.05). The CAR was 0.0972±0.16 in patients who had low disease activity and 0.213±0.275 in patients with high disease activity. The patients with high disease activity had higher CAR than patients with low disease activity (p<0.05). There was a statistically significant positive correlation between CAR and BASDAI and ASDAS respectively (rho 327, p<0.05, rho 0.523, p<0.05). The AGR was lower in AxSpA patients (p<0.05). There was a negative correlation between AGR and BASDAI but it was not significant (rho – 0.044, p>0.05). There was significant correlation between PLR and BASDAI and ASDAS (rho 236, p<0.05 and rho 314, p<0.05 respectively). Conclusion: The CAR and PLR are an important markers for evaluating disease activity in patients with AxSpA. AGR may be a promising marker for assessing disease activity in AxSpA.
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Beyazıt, Fatma, Eren Pek, and Hakan Türkön. "Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum." Medical Bulletin of Haseki 56, no. 4 (2018): 292–98. http://dx.doi.org/10.4274/haseki.4019.
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Ryberg, Line A., Pernille Sønderby, Fabian Barrientos, Jens T. Bukrinski, Günther H. J. Peters, and Pernille Harris. "Solution structures of long-acting insulin analogues and their complexes with albumin." Acta Crystallographica Section D Structural Biology 75, no. 3 (2019): 272–82. http://dx.doi.org/10.1107/s2059798318017552.
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The lipidation of peptide drugs is one strategy to obtain extended half-lives, enabling once-daily or even less frequent injections for patients. The half-life extension results from a combination of self-association and association with human serum albumin (albumin). The self-association and association with albumin of two insulin analogues, insulin detemir and insulin degludec, were investigated by small-angle X-ray scattering (SAXS) and dynamic light scattering (DLS) in phenolic buffers. Detemir shows concentration-dependent self-association, with an equilibrium between hexamer, dihexamer, trihexamer and larger species, while degludec appears as a dihexamer independent of concentration. The solution structure of the detemir trihexamer has a bent shape. The stoichiometry of the association with albumin was studied using DLS. For albumin–detemir the molar stoichiometry was determined to be 1:6 (albumin:detemir ratio) and for albumin–degludec it was between 1:6 and 1:12 (albumin:degludec ratio). Batch SAXS measurements of a 1:6 albumin:detemir concentration series revealed a concentration dependence of complex formation. The data allowed the modelling of a complex between albumin and a detemir hexamer and a complex consisting of two albumins binding to opposite ends of a detemir dihexamer. Measurements of size-exclusion chromatography coupled to SAXS revealed a complex between a degludec dihexamer and albumin. Based on the results, equilibria for the albumin–detemir and albumin–degludec mixtures are proposed.
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Abdou, Khaled, Madonna Mounir Salama, Samia Abdelmohsen, Sameh Salem, and Ahmed Ali. "C-reactive protein/albumin ratio versus lactate/albumin ratio as an outcome predictor for patients with sepsis and septic shock in hospital stay." Anaesthesia, Pain & Intensive Care 28, no. 5 (2024): 901–7. http://dx.doi.org/10.35975/apic.v28i5.2571.
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Background & Objective: Pre-emptively identifying individuals at risk of developing sepsis and septic shock remains challenging. In septic patients, the Lactate/Albumin Ratio (LAR) and C-reactive protein (CRP)/Albumin ratio (CAR) have been suggested to be promising prognostic indicators for prediction of intensive care unit (ICU) mortality. We compared the prognostic values of CAR and LAR in patients with sepsis and septic shock. Methodology: Eighty adult patients diagnosed with sepsis and admitted to the ICUs of Ain Shams University Hospitals, were included in this observational prospective study. CRP levels, serum lactate, serum albumin, complete blood count (CBC), procalcitonin levels, and SOFA scores were assessed upon admission, with subsequently observing 28-day mortality among the selected patients. Results: CAR values were comparable between the mortality and survival groups (P = 0.807). However, LAR values were significantly elevated in the mortality group vs the survival group (P = 0.044). ROC analysis for mortality indicated that LAR had an AUC of 0.633 at a cutoff value > 0.68, achieving sensitivity and specificity of 89.4% and 21.2%, respectively. In contrast, CAR had an AUC of 0.484 at a cutoff value ≥ 1.54, with sensitivity and specificity values of 63.8% and 57.6%, respectively. Length of ICU stay (P < 0.001), duration of mechanical ventilation (P < 0.001), cardiovascular support (P < 0.001) and the need for renal replacement therapy (P < 0. 039), were increased in the mortality group compared to the survival group. Conclusion: Lactate/albumin ratio is superior and more reliable bio-marker predictor compared to C-reactive protein (CRP)/albumin ratio for ICU mortality. Abbreviations: CAR - C-reactive protein/albumin ratio; CRP - C-reactive protein; ICU - intensive care unit; LAR - Lactate/Albumin Ratio; Keywords: Albumin; CRP To Albumin Ratio; Lactate; Lactate to Albumin Ratio; Mortality; Sepsis; Septic Shock; SOFA; Survival Citation: Abdou K, Mounir M, Abdelmohsen S, Salem S, Ali A. C-reactive protein/albumin ratio versus lactate/albumin ratio as an outcome predictor for patients with sepsis and septic shock in hospital stay. Anaesth. pain intensive care 2023;28(5):901−907; DOI: 10.35975/apic.v27i5.2571 Received: July 29, 2024; Reviewed: August 23, 2024; Accepted: August 28, 2024
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Zheng, Yin, Feng Zhuang, Qiuyu Zhu, et al. "Albumin-corrected Total/Ionized Calcium Ratio is not Superior to Total/Ionized Calcium Ratio as an Indicator of Citrate Accumulation." International Journal of Artificial Organs 40, no. 11 (2017): 602–6. http://dx.doi.org/10.5301/ijao.5000621.
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Background Total/ionized calcium ratio has been used as an indirect index of increased plasma citrate concentration during citrate anticoagulation. However, they were obtained without any adjustment of total calcium for albumin. Herein, we investigated whether the albumin-corrected total/ionized calcium ratio performed better than total/ionized calcium ratio. Methods 20 critically ill patients were treated with continuous venovenous hemofiltration (CVVH) using citrate anticoagulation. The systemic total, ionized calcium and albumin levels were dynamically measured, and correlations between different calcium parameters and plasma citrate levels were analyzed. Results The highest correlation was found between plasma citrate level and total/ionized calcium ratio at the third hour (R = 0.88, p<0.001). The albumin-corrected total/ionized calcium ratio was not superior to total/ionized calcium ratio. Conclusions The total/ionized calcium ratio at the third hour after the start of citrate-CVVH is an early and simple indicator to reflect increased plasma citrate level. Adjustment of systemic total calcium for serum albumin is not necessary.
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Indu, Khare, Swati, Sinha Sangeeta, and Singh Sunita. "Evaluation of CRP/Albumin Ratio in Polycystic Ovarian Syndrome." International Journal of Pharmaceutical and Clinical Research 16, no. 12 (2024): 1244–49. https://doi.org/10.5281/zenodo.14601673.
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<strong>Introduction: </strong>Polycystic Ovarian Syndrome (PCOS), an endocrine disorder that disproportionately affects reproductive-aged women, causes hormonal imbalance, metabolic dysfunction, and persistent low-grade inflammation. Since inflammation is fundamental to polycystic ovarian syndrome (PCOS), indicators including C-reactive protein (CRP) and albumin are used to assess inflammation. The CRP/Albumin ratio is a new indication of diet-systemic inflammation relationship. The major goal of this study was to establish the clinical relevance of the CRP/Albumin ratio in PCOS patients. <strong>Objective: </strong>The study aimed to compare PCOS-diagnosed women’s CRP/Albumin ratio to healthy controls. One secondary purpose was to determine if CRP/Albumin correlated with other clinical factors including insulin resistance and BMI. <strong>Materials and Methods: </strong>At Patna Medical College and Hospital, 200 women with PCOS were recruited from June 2023 to May 2024 a retrospective cross-sectional study. Clinical data like CRP and albumin were collected from medical records. Participants were 18–40-year-old women with Rotterdam-diagnosed polycystic ovary syndrome (PCOS). Patient exclusion criteria included pregnancy, other inflammatory disorders, and recent infections. For biochemical and demographic data, we used descriptive statistics, and for CRP/Albumin ratio and other clinical variable patterns, we used correlation analysis. We used SPSS for statistical analysis. <strong>Results: </strong>The study found that PCOS patients had higher CRP levels (7.8 ± 3.5 mg/L) than controls (2.2 ± 1.0 mg/L) but lower albumin levels (4.1 ± 0.5 g/dL vs. 4.5 ± 0.4 g/dL). In PCOS patients, the average CRP/Albumin ratio was 1.9, significantly greater than the control group’s 0.5 ratio (p < 0.001). Insulin resistance, BMI, and CRP/Albumin ratio were strongly linked (r = 0.38, p < 0.001). <strong>Conclusion: </strong>The elevated CRP/Albumin ratio suggests ongoing low-grade inflammation in polycystic ovary syndrome (PCOS) patients. This ratio can identify patients at risk for metabolic issues like insulin resistance and cardiovascular disease and assess polycystic ovary syndrome (PCOS) inflammation. This ratio may monitor therapy response, but further research is needed to determine its clinical usefulness in PCOS diagnosis and management.
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Park, Ji, Kyung Chung, Joo Song, et al. "The C-Reactive Protein/Albumin Ratio as a Predictor of Mortality in Critically Ill Patients." Journal of Clinical Medicine 7, no. 10 (2018): 333. http://dx.doi.org/10.3390/jcm7100333.
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The C-reactive protein (CRP)/albumin ratio has recently emerged as a marker for poor prognosis or mortality across various patient groups. This study aimed to identify the association between CRP/albumin ratio and 28-day mortality and predict the accuracy of CRP/albumin ratio for 28-day mortality in medical intensive care unit (ICU) patients. This was a retrospective cohort study of 875 patients. We evaluated the prognostic value of CRP/albumin ratio to predict mortality at 28 days after ICU admission, using Cox proportional hazard model and Kaplan-Meier survival analysis. The 28-day mortality was 28.0%. In the univariate analysis, the Acute Physiology and Chronic Health Evaluation II (APACHE II) score (p < 0.001), CRP level (p = 0.045), albumin level (p < 0.001), and CRP/albumin ratio (p = 0.032) were related to 28-day mortality. The area under the receiver operating characteristic (ROC) curve (the area under the ROC curves (AUC)) of CRP/albumin ratio was higher than that of CRP for mortality (0.594 vs. 0.567, p < 0.001). The cut-off point for CRP/albumin ratio for mortality was 34.3. On Cox proportional-hazard regression analysis, APACHE II score (hazards ratio (HR) = 1.05, 95% confidence interval (CI) = 1.04–1.07, p < 0.001) and CRP/albumin ratio (HR = 1.68, 95% CI = 1.27–2.21, p < 0.001 for high CRP/albumin ratio) were independent predictors of 28-day mortality. Higher CRP/albumin ratio was associated with increased mortality in critically ill patients.
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Xu, Qiaodong, Yongcong Yan, Songgang Gu, et al. "A Novel Inflammation-Based Prognostic Score: The Fibrinogen/Albumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma." Journal of Immunology Research 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/4925498.
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Background. Inflammation is an important hallmark of cancer. Fibrinogen and albumin are both vital factors in systemic inflammation. This study investigated the prognostic value of the fibrinogen/albumin ratio in HCC patients who underwent curative resection. Methods. HCC patients (n=151) who underwent curative resection were evaluated retrospectively. The optimal cutoff value for the fibrinogen/albumin ratio was selected by receiver operating characteristic (ROC) curve analysis. Correlations between preoperative fibrinogen/albumin ratios and clinicopathologic characteristics were analyzed by χ2 test. The area under the receiver operating characteristic curve (AUC) was calculated to compare the prognostic value of the fibrinogen/albumin ratio with other prognostic scores (neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and albumin-bilirubin (ALBI) score). The overall survival (OS) and time to recurrence (TTR) were assessed by the log-rank test and the Cox proportional hazard regression model. Results. An optimal cutoff value of the preoperative fibrinogen/albumin ratio (0.062) was determined for 151 patients who underwent curative resection for HCC via a ROC curve analysis. Fibrinogen/albumin ratio > 0.062 was significantly associated with microvascular invasion, an advanced BCLC stage, and ALBI grade. Multivariate analyses revealed that fibrinogen/albumin ratio was an independent predictor for OS (P=0.003) and TTR (P=0.035). The prognostic ability of fibrinogen/albumin ratio was comparable to other prognostic scores (NLR, PLR, and ALBI score) by AUC analysis. Patients with a fibrinogen/albumin ratio > 0.062 had lower 1-, 3-, and 5-year OS rates (66.0%, 41.8%, and 28.2% versus 81.9%, 69.3%, and 56.1%, resp., P<0.001) and higher 1-, 3-, and 5-year recurrence rates (60.9%, 79.2%, and 90.5% versus 49.5%, 69.1%, and 77.1%, resp., P=0.008) compared with patients with fibrinogen/albumin ratio ≤ 0.062. Conclusion. The preoperative fibrinogen/albumin ratio is an effective prognostic factor for HCC patients who underwent curative resection. An elevated fibrinogen/albumin ratio significantly correlates with poorer survival and a higher risk of recurrence in HCC patients.
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Khalil, KotbAbbass Metwalley, and Leif Jansson. "ASSESSMENT OF CORRELATION OF LACTATE /ALBUMIN RATIO IN SEPSIS PATIENTS ADMITTED IN ICU." Journal Of Healthcare In Developing Countries 1, no. 1 (2021): 11–16. http://dx.doi.org/10.26480/jhcdc.01.2021.11.16.
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Sepsis is life-threatening organ dysfunction caused by dysregulated host responses to infection, and septic shock is a subset of sepsis in which underlying circulatory and cellular/metabolic abnormalities are sufficiently profound to substantially increase mortality. Patients with sepsis are usually treated in the intensive care unit (ICU). Hence; under the light of above-mentioned data, the present study was undertaken for determining the correlation of lactate /albumin ratio in outcome of patients of sepsis in ICU. The present study was undertaken for determining the correlation of lactate /albumin ratio in outcome of patients of sepsis in ICU. A total of 30 patients were enrolled. The resulting patients were subjected to detailed history and examination followed by investigations (CBC, ESR, CRP), Bacterial culture, liver function test, renal function test, arterial blood gas analysis for lactate, serum albumin level). Mean Lactate value was 4.59 while mean albumin value was 25.12. Mean lactate to albumin ratio was 0.18. While correlating lactate to albumin ratio with Serum Procalcitonin levels, significant results were obtained. While correlating lactate to albumin ratio, it was seen that higher lactate to albumin ratio was associated with higher mortality. Lactate/albumin ratio is an independent predictor for the mortality among sepsis patients admitted to ICU.
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Haq, Haseeb ul, S. V. Raghunath, and Channamaneni Amithkumar. "Early Predictors of Hyperbilirubinemia in Full Term Newborn." Perspectives in Medical Research 10, no. 3 (2022): 100–104. http://dx.doi.org/10.47799/pimr.1003.18.
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Abstract Introduction: Predictive markers enabling Pediatricians to identify which neonates will develop jaundice have mandatory for prevention of severe hyperbilirubinemia. We aim to determine the critical cord bilirubin and albumin levels and bilirubin/albumin ratio. Design: This prospective study included131full-termnewborns. Hyperbilirubinemia can be predicted by Measuring cord bilirubin , albumin and bilirubin/albumin ratio. Results: Neonatal hyperbilirubinemia (67.8%) had cord albumin level less than or equal to 2.7gm/dl. CordBilirubin/albumin ratio cutoff value greater than 0.62 had a good predictive value with a sensitivity of 100% and specificity of 88.36%, Conclusion: neonatal hyperbilirubinemia predictors are Cord BILIRUBIN/ALBUMIN ratio , serum bilirubin and albumin.
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Ahlfors, Charles E. "Criteria for Exchange Transfusion in Jaundiced Newborns." Pediatrics 93, no. 3 (1994): 488–94. http://dx.doi.org/10.1542/peds.93.3.488.
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Objective. A widely published set of exchange transfusion criteria lowers critical bilirubin concentrations when the serum albumin falls to &lt;2.5 g/dL. Although acknowledging the role of bilirubin-albumin binding in bilirubin neurotoxidty, this approach may inadvertently produce two critical bilirubin concentrations. This study investigates using the bilirubin/albumin ratio instead of the single albumin concentration to eliminate this potential ambiguity in the criteria. Design and participants. The bilirubin/albumin ratio was defined as a reliable indicator of bilirubin-albumin binding if the frequency curves of specific unbound bilirubin concentrations are normally distributed functions of the ratio. Therefore the bilirubin/albumin ratios at which the unbound bilirubin reached 10, 15, and 20 nmol/L were determined by the peroxidase method in 35 well full-term, 10 ill full-term, and 19 ill preterm neonates. The frequency curves for each unbound bilirubin concentration plotted against the bilirubin/albumin ratio were tested for normality. Results. The frequency of each unbound bilirubin concentration was a normally distributed function of the bilirubin/albumin ratio. Furthermore, the mean ratio at which each unbound bilirubin occurred did not differ significantly among the groups of neonates. Conclusion. The bilirubin/albumin ratio is a simple, nonambiguous way of incorporating the serum albumin concentration into exchange transfusion criteria.
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Domjanović, Josipa, Tea Domjanović Škopinić, Josipa Radić, Mirko Luketin, Ivo Jeličić, and Andrija Matetic. "Performance of Derived Laboratory Biomarkers with Regard to 30-Day Mortality in Kidney Transplant Recipients with COVID-19." Life 12, no. 12 (2022): 2068. http://dx.doi.org/10.3390/life12122068.
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There are limited data on the performance of laboratory-derived biomarkers in kidney transplant recipients (KTR) with COVID-19. This observational study enrolled 65 KTR with COVID-19 who were treated at the University Hospital of Split up to March 2022. Laboratory-derived biomarkers (neutrophile-to-lymphocyte (NLR) ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, De Ritis ratio, C-reactive protein (CRP)-to-albumin ratio, lactate dehydrogenase (LDH)-to-hemoglobin ratio, CRP-to-lymphocyte ratio, red cell distribution width-to-albumin ratio, platelet-to-albumin ratio, D-Dimer-to-albumin ratio, D-Dimer-to-NLR ratio, LDH-to-albumin ratio, and LDH-to-white blood cell (WBC) ratio) were calculated, and their performance with regard to 30-day mortality was determined. Mortality events occurred in 12 patients (18.5%), which was significantly associated with increased De Ritis (HR 3.83, 95% CI 1.57–9.35, p = 0.003), CRP-to-albumin (HR 1.36, 95% CI 1.13–1.64, p = 0.001), LDH-to-hemoglobin (HR 1.44, 95% CI 1.07–1.92, p = 0.015), CRP-to-lymphocyte (HR 1.03, 95% CI 1.01–1.07, p = 0.003), D-dimer-to-albumin (HR 4.94, 95% CI 1.38–7.24, p = 0.038), LDH-to-albumin (HR 1.20, 95% CI 1.05–1.36, p = 0.008), and LDH-to-WBC (HR 1.03 95% CI 1.01–1.05, p = 0.024) ratios. Out of these, the best area-under-the-curve (AUC) values were achieved with De Ritis (AUC 0.691), CRP-to-albumin (AUC 0.764), LDH-to-hemoglobin (AUC 0.877), CRP-to-lymphocyte (AUC 0.739), and LDH-to-albumin (AUC 0.827) ratios, while the best discrimination displayed LDH-to-hemoglobin ratio (Harrell’s C 0.808 and Somers’ D 0.616). The overall calibration was satisfactory for all models. Derived laboratory biomarkers such as the de Ritis, CRP-to-albumin, LDH-to-hemoglobin, CRP-to-lymphocyte, and LDH-to-albumin ratios show significant association and discrimination with all-cause mortality in KTR with COVID-19, suggesting its potential risk stratification role.
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Hutchison, A. S., D. S. O'Reilly, and A. C. MacCuish. "Albumin excretion rate, albumin concentration, and albumin/creatinine ratio compared for screening diabetics for slight albuminuria." Clinical Chemistry 34, no. 10 (1988): 2019–21. http://dx.doi.org/10.1093/clinchem/34.10.2019.
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Abstract Slight albuminuria, an overnight albumin excretion rate (AER) greater than 30 micrograms/min in an "Albustix"-negative sample, predicts development of diabetic nephropathy. This study compares the AERs for 261 timed overnight urine collections with the albumin concentrations and albumin/creatinine ratios for the same specimens (equivalent to first morning specimens). Thirty-one specimens (11.9%) had AERs greater than 30 micrograms/min. Use of an albumin/creatinine ratio greater than 3.0 mg/mmol to predict an AER greater than 30 micrograms/min gave a sensitivity of 96.8%, a specificity of 93.9%, and a predictive value of 68.2%, with a correlation coefficient of 0.921. Use of an albumin concentration greater than 17 mg/L gave a sensitivity of 96.8%, a specificity of 90.9%, a predictive value of 58.8%, and a slightly poorer correlation (r = 0.904). Evidently either method is acceptable as an initial screening procedure, but determination of albumin concentration alone would be preferable because of lesser cost.
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Bayram, Ertugrul, Mehmet Mutlu Kidi, Yasemin Aydınalp Camadan, et al. "Can the Pathological Response in Patients with Locally Advanced Gastric Cancer Receiving Neoadjuvant Treatment Be Predicted by the CEA/Albumin and CRP/Albumin Ratios?" Journal of Clinical Medicine 13, no. 10 (2024): 2984. http://dx.doi.org/10.3390/jcm13102984.
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Background: The purposes of neoadjuvant chemotherapy are to tumor size to improve the tumor removal rate, extend survival, and prevent metastasis. In this study, the importance of CRP/albumin ratio and CEA/albumin ratio in the prediction of neoadjuvant treatment response in gastric cancer patients was evaluated. Methods: This study retrospectively included 135 gastric cancer patients who received neoadjuvant chemotherapy at Çukurova University Balcalı Hospital between January 2018 and December 2023. Preoperative CRP/albumin and CEA/albumin ratios were compared according to treatment response and multivariate logistic regression analysis was performed to determine the potential importance of these ratios in predicting pathological response. Results: The mean age of the 135 patients was 58.79 ± 10.83 (min = 26–max = 78). The CRP/albumin and CEA/albumin ratios were found to be significantly lower in patients who did not respond to neoadjuvant therapy. Each 1-unit increase in the CRP/albumin ratio was associated with a 1.16-fold decrease in the odds of pathological complete response to neoadjuvant therapy. Both CRP/albumin and CEA/albumin ratios were found to be significant in distinguishing neoadjuvant therapy response. The optimal cut-off value was 2.74 for the CRP/albumin ratio (sensitivity = 60%, specificity = 78.4%) and 1.40 for the CEA/albumin ratio (sensitivity = 74.2%, specificity = 67.6%). Values below these cut-off points favored neoadjuvant therapy response. Pathological complete response to neoadjuvant therapy was 4.75 times higher in patients with a CRP/albumin ratio below 2.74 and 5.14 times higher in patients with a CEA/albumin ratio below 1.40. Conclusions: Findings demonstrate that in patients with locally advanced gastric cancer receiving neoadjuvant treatment, CRP/Albumin and CEA/Albumin ratios are significant markers of pathological response.
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Soylu, Veysel Garani, Esma Karahan, Ayşe Yılmaz, Öztürk Taşkın, and Ufuk Demir. "Assessment of the relationship between C-Reactive Protein/Albumin ratio and 28-day mortality in critically very elderly patients (≥ 85 years) with acute ischemic stroke." Neurology Asia 27, no. 3 (2022): 575–81. http://dx.doi.org/10.54029/2022kwi.
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Background & Objectives: The aim of this study is investigate the relationship of C-reactive protein, albumin, C-reactive protein/albumin ratio with prognosis and 28-day mortality in critically ill patients over 85 years of age with acute ıschaemic stroke. Methods: This study is a retrospective and observational study. A total of 189 patients aged 85 years and older who were followed up in the intensive care unit between 2017 and 2020 were included in the study. Demographic data of the patients included in the study, length of stay in the intensive care unit, comorbidities, laboratory data of hospitalization in the intensive care unit, C-reactive protein, albumin, C-reactive protein/albumin ratio, neutrophil/lymphocyte ratios, thrombocyte/lymphocyte ratios, APACHE II, SAPS II values of intensive care admissions were recorded. Results: In the statistical analysis performed for C-reactive protein, albumin, C-reactive protein/albumin ratio between survival and non-survival groups, a statistically significant difference was found between the groups (For C-reactive protein, p = 0.03; for albumin, p = 0.02; for C-reactive protein/albumin ratio, p= 0.03). The logistic regression model was applied to investigate the independent risk factors affecting the patients’ mortality at 28 days. Albumin, CRP , C-reactive protein/albumin ratio was found to be associated with 28-day mortality according to the logistic regression analysis. (For albumin; p= 0.04, for C-reactive protein; p= 0.04, for C-reactive protein/albumin ratio; p= 0.04). According to the ROC curve analysis result, Cut-off value was found to be 2.47 for C-reactive protein/albumin ratio. Conclusion: The CRP/albumin ratio is a valuable parameter that can be used to predict 28-day mortality in critically ill very elderly patients with acute ischemic stroke.
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Jeong, Jong Hwan, Manbong Heo, Seung Jun Lee, Yi Yeong Jeong, Jong Deog Lee, and Jung-Wan Yoo. "Clinical Usefulness of Red Cell Distribution Width/Albumin Ratio to Discriminate 28-Day Mortality in Critically Ill Patients with Pneumonia Receiving Invasive Mechanical Ventilation, Compared with Lacate/Albumin Ratio: A Retrospective Cohort Study." Diagnostics 11, no. 12 (2021): 2344. http://dx.doi.org/10.3390/diagnostics11122344.
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The value of the red cell distribution width (RDW) is associated with prognosis in critically ill patients. A simplex combined index—the RDW/albumin ratio—has been proposed for the prediction of mortality, as has the lactate/albumin ratio. The aim of this study was to evaluate the clinical utility of the RDW/albumin ratio regarding 28-day mortality in critically ill patients with pneumonia. Clinical data of critically ill patients with pneumonia who were hospitalized in the medical intensive care unit from May 2018 to December 2020, and received invasive mechanical ventilation (IMV), were reviewed retrospectively. The values of RDW, lactate, and albumin measured at the time of IMV, were used for the index calculations. Of the 234 patients, the median age was 76 years, and 74.2% were male. The 28-day mortality rate was 47.3%. The median RDW/albumin ratio was significantly higher in non-survivors than survivors at 28 days (5.8 vs. 4.9, p < 0.001). A higher RDW/albumin ratio was significantly associated with increased 28-day mortality (odds ratio [OR] 1.338, 95% confidence interval [CI] 1.094–1.637, p = 0.005). The area under the receiver operating curve (AUROC) was 0.694 (95% CI: 0.630–758, p < 0.005) to discern 28-day mortality without significant difference, compared with that of the lactate/albumin ratio. Our data suggest that high RDW/albumin ratio has a similar predictability to the lactate/albumin ratio in critically ill patients with pneumonia receiving IMV.
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Dong, Geng, Tingting Ma, Zhe Xu, et al. "Fibrinogen-to-Albumin Ratio in Neonatal Sepsis." International Journal of General Medicine Volume 16 (October 2023): 4965–72. http://dx.doi.org/10.2147/ijgm.s432903.
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Shivaswamy, Rajendra Prasad, Nithin Sai Inaganti, Tandure Varsha, et al. "Assessing the prognostic value of C-reactive protein/albumin ratio and lactate/albumin ratio in critically ill patients." Journal of Dr. YSR University of Health Sciences 13, no. 2 (2024): 119–27. http://dx.doi.org/10.4103/jdrysruhs.jdrysruhs_219_22.
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ABSTRACT Background: The ability to predict the fate of critically ill patients admitted to an intensive care unit is very important as there are only a few studies which have focused on this aspect. Our study focused to determine the relationship between C-reactive protein/albumin ratio (CAR) and lactate/albumin ratio (LAR) and intensive care unit stay, the requirement for vasopressor and mechanical ventilator support, and recovery and mortality in the patients admitted to critical care units. Methods: The study group comprised 100 patients who were admitted to critical care units. These patients were evaluated using a structured proforma, detailed case history, and clinical examination. Blood sample collection was done immediately after admission, and serum albumin, lactate, and C-reactive protein levels were estimated in these patients. Results: The mean age of the patients was 54.05. 74% of the patients were males. The common diagnosis was COVID bronchopneumonia. The patients with high LAR and high CAR values had either increased risk of mortality or increased duration of stay in the hospital (P = 0.0001). Patients with a low albumin level and high CRP required ventilator support, which was statistically significant. Patients who needed inotropic support and mechanical ventilator support had higher CAR (P = 0.001). Patients who received inotrope support had higher ESR and CRP levels. Conclusions: CAR and LAR are better indicators of mortality and duration of stay. CAR was found to be a better indicator of mortality than LAR, and it was also noted that the patients who required inotropes and mechanical ventilator support were found to have a higher CAR.
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Kamal, Doaa E., Rabab S. Zaghlol, Marwa H. S. Hussien, and Wafaa K. Makarm. "Utility of neutrophil/albumin ratio and C-reactive protein/albumin ratio as novel inflammatory markers in Behcet's disease." Reumatología Clínica (English Edition) 19, no. 4 (2023): 188–96. http://dx.doi.org/10.1016/j.reumae.2023.03.005.
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Zhang, Xiao-Jie, He Fei, Chong-Yuan Sun, et al. "Novel prognostic score based on the preoperative total bilirubin-albumin ratio and fibrinogen-albumin ratio in ampullary adenocarcinoma." World Journal of Gastrointestinal Surgery 15, no. 10 (2023): 2247–58. http://dx.doi.org/10.4240/wjgs.v15.i10.2247.
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Postcholecystectomy bile duct injury (BDI) remains a devastating iatrogenic complication that adversely impacts the quality of life with high healthcare costs. Despite a decrease in the incidence of laparoscopic cholecystectomy-related BDI, the absolute number remains high as cholecystectomy is a commonly performed surgical procedure. Open Roux-en-Y hepaticojejunostomy with meticulous surgical technique remains the gold standard surgical procedure with excellent long-term results in most patients. As with many hepatobiliary disorders, a minimally invasive approach has been recently explored to minimize access-related complications and improve postoperative recovery. Since patients with gallstone disease are often admitted for a minimally invasive cholecystectomy, laparoscopic and robotic approaches for repairing postcholecystectomy biliary stricture are attractive. While recent series have shown the feasibility and safety of minimally invasive post-cholecystectomy biliary stricture management, most are retrospective analyses with small sample sizes. Also, long-term follow-up is available only in a limited number of studies. The principles and technique of minimally invasive repair resemble open repair except for the extent of adhesiolysis and the suturing technique with continuous sutures commonly used in minimally invasive approaches. The robotic approach overcomes key limitations of laparoscopic surgery and has the potential to become the preferred minimally invasive approach for the repair of postcholecystectomy biliary stricture. Despite increasing use, lack of prospective studies and selection bias with available evidence precludes definitive conclusions regarding minimally invasive surgery for managing postcholecystectomy biliary stricture. High-volume prospective studies are required to confirm the initial promising outcomes with minimally invasive surgery.
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Zhao, Subei, Zheng Yang, Meng Yu, et al. "Influence of Fibrinogen/Albumin Ratio and Fibrinogen/Pre-Albumin Ratio on Cardiac Autonomic Neuropathy in Type 2 Diabetes." Diabetes, Metabolic Syndrome and Obesity Volume 16 (October 2023): 3249–59. http://dx.doi.org/10.2147/dmso.s431551.
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YÜCE, Elif, and Evren FİDAN. "Gamma-Glutamyl Transferase/Albumin Ratio and Alkaline Phosphatase/Albumin Ratio as Novel Prognostic Markers for Metastatic Pancreatic Cancer." Journal of Oncological Sciences 9, no. 3 (2023): 128–33. http://dx.doi.org/10.37047/jos.2022-94940.
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Taşkin, Öztürk, Ayşe Yilmaz, Veysel Garani Soylu, Ufuk Demir, and Funda Çatan Inan. "Ferritin / albumin ratio could be a new indicator of COVID-19 disease mortality." Journal of Infection in Developing Countries 17, no. 01 (2023): 37–42. http://dx.doi.org/10.3855/jidc.17409.
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Introduction: Despite significant advances in the management of patients with COVID-19, there is a need for markers to guide treatment and predict disease severity. In this study, we aimed to evaluate the relationship of the ferritin/albumin (FAR) ratio with disease mortality. Methodology: Acute Physiology and Chronic Health Assessment II scores and laboratory results of patients diagnosed with severe COVID-19 pneumonia were retrospectively analyzed. The patients were divided into two groups: survivors and non-survivors. Data for ferritin, albumin, and ferritin/albumin ratio among COVID-19 patients were analyzed and compared. Results: The mean age was higher in non-survivors (p = 0.778, p < 0.001, respectively). The ferritin/albumin ratio was significantly higher in the non-survival group (p < 0.05). Taking the cut-off value of the ferritin/albumin ratio of 128.71 in the ROC analysis, it predicted the critical clinical status of COVID-19 with 88.4% sensitivity and 88.4% specificity. Conclusions: ferritin/albumin ratio is a practical, inexpensive, and easily accessible test that can be used routinely. In our study, the ferritin/albumin ratio has been identified as a potential parameter in determining the mortality of critically ill COVID-19 patients treated in intensive care.
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Guclu, Hande, Sadık A. Ozal, Vuslat Pelitli Gurlu, Gülben Sayılan Özgün, and Eray Özgün. "Increased Fibrinogen to Albumin Ratio in Ischemic Retinal Vein Occlusions." European Journal of Ophthalmology 27, no. 6 (2017): 735–39. http://dx.doi.org/10.5301/ejo.5000942.
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Purpose To demonstrate the relationship between ischemia and plasma fibrinogen and serum albumin levels in cases of retinal vein occlusion (RVO). Methods This study included 44 patients with central RVO (CRVO), 68 patients with branch RVO (BRVO), and 54 age- and sex-matched controls, for a total of 166 subjects. All of the subjects underwent full ophthalmologic examinations and complete physical examinations, including a detailed medical history and blood count, and biochemical parameters. Results The mean fibrinogen to albumin ratios were 92.5 ± 36.1 for the patients with CRVO, 84.5 ± 31.5 for the patients with BRVO, and 68.4 ± 12.2 for the control group. Overall, the patients with CRVO and patients with BRVO with ischemia had higher fibrinogen to albumin ratios and higher fibrinogen levels. Moreover, significant positive correlations were found between ischemia and the fibrinogen to albumin ratio (r = 0.732, p = 0.001) and the fibrinogen level (r = 0.669, p = 0.001). Conclusions The fibrinogen to albumin ratio is significantly associated with ischemic RVO. Instead of complicated and invasive methods, such as a retinal angiogram, the fibrinogen to albumin ratio could be a useful initial diagnostic test to predict ischemia in RVO.
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Dimitrijević, Jelena, Marina Čalamać, Ognjen Đurmez, and Marko Stojanović. "PCT-to-albumin ratio and CRP-to-albumin ratio as predictors of febrile neutropenia complications: a prospective observational trial." Supportive Care in Cancer 33, no. 4 (2025): 262. https://doi.org/10.1007/s00520-025-09329-5.
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Abstract <strong>Purpose: </strong>This study aimed to determine whether procalcitonin-to-albumin ratio (PAR) and C-reactive protein-to-albumin ratio (CAR) can be alternatives to the Multinational Association for Supportive Care in Cancer (MASCC) risk index score in predicting bacteriemia, septicemia, death during FN, and 28-day mortality, in patients with febrile neutropenia (FN). <strong>Methods: </strong>This is a prospective observational study that included 185 participants with FN. Clinical and laboratory findings like PAR and CAR were analyzed, and their ability to predict FN complications was investigated. <strong>Results: </strong>From the included population, the 91 subjects (49.46%) had low-risk FN with MASCC risk index ≥ 21. Sixteen participants (8.70%) had bacteremia, and eight developed septicemia (4.89%). Before resolving FN, 15 people died, and in total 33 died within 28 days of diagnosis. The ROC curve analysis indicates that the CAR (p = 0.0008921) better predicts mortality during FN, and the PAR (p = 0.0003535) better predicts bacteremia. Incorporating CAR values into the MASCC risk index predicts mortality by as much as 33.33% more precisely than the MASCC risk index alone. The CAR values > 2.74 were an independent predictor of 28-day mortality (OR = 3.70; 95% CI = 1.08-13.02; p = 0.0376). <strong>Conclusion: </strong>The study results suggest that PAR and CAR can be leveraged as valuable prognostic tools in predicting bacteremia, septicemia, mortality during FN, and 28-day mortality in patients with FN.
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Emeka, Callistus Onyeka Izuchukwu, Solomon Adedapo Kayode, Stella Akingbola Titilola, et al. "Assessment of growth arrest-specific 6 protein as a biomarker of glomerular damage in sickle cell anaemia." GSC Advanced Research and Reviews 16, no. 1 (2023): 036–45. https://doi.org/10.5281/zenodo.8271898.
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Objective: To assess growth arrest-specific 6 (Gas6) protein as a biomarker of glomerular damage (glomerulopathy; nephropathy) in patients with sickle cell anaemia (SCA). Methods: seventy SCA patients on routine clinic visit and seventy apparently healthy controls were recruited into the study and their blood and urine samples were collected while plasma Gas6 as well as urinary albumin and creatinine measured. Their socio-demographic and other anthropometric indices were documented. The study participants and controls were screened for urinary tract infection (UTI) using the urine dipstick combi-10 on their urine. The plasma Gas6 of all patients were compared with the albumin creatinine ratio (ACR) along with the ages. Albumin and creatinine levels were also compared with ages. Results: Gas6 had an inverse though insignificant relationship with ACR and age in the patients; albumin, creatinine and albumin creatinine ratio varied directly with age in these patients. Conclusion: Gas 6 was not found a useful marker of glomerulopathy in sickle cell anaemia.
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Mazen, Mazen, Achmad Rifai, and Atma Gunawan. "The association between albumin levels, platelet-to-albumin ratio, and the likelihood of peritonitis occurrence in individuals undergoing peritoneal dialysis." Deka in Medicine 1, no. 1 (2024): e887. http://dx.doi.org/10.69863/dim.v1i1.4.
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BACKGROUND: Since albumin and platelet had been reported to govern the risk of infection, their impact in the case of peritoneal dialysis (PD) – related peritonitis should be investigated. OBJECTIVES: To assess the association between albumin levels and platelet – to – albumin ratio and the risk of PD-related peritonitis. METHODS: We conducted a retrospective study in Saiful Anwar General Hospital, Malang, Indonesia during July 2019 and July 2021. Data related to albumin levels and platelet – to – albumin ratio as well as the incidence of PD-related peritonitis were collected from medical record using a standardized pilot form. The association between the albumin levels and platelet – to – albumin ratio and the risk of PD-related peritonitis was analyzed using multiple logistic regression. RESULTS: We included 123 PD patients during study period. Of them, 20 patients were PD-related peritonitis. Our study found that lower albumin levels were associated with increased risk of PD-related peritonitis with the mean difference was -0.30 (MD: -0.30; 95%CI: [-0.55], [-0.05]). We also found that platelet – to – albumin ratio was observed higher in PD-related to peritonitis compared to control (MD: 14420.10; 95%CI: 832.08, 28008.12). However, the role of albumin levels and platelet – to – albumin ratio had weak association to the risk of PD-related peritonitis with the area under curve were 61% and 59%, respectively. CONCLUSION: Our study provides the preliminary data regarding the potential role of albumin and platelet – to – albumin ratio for predicting the risk of PD-related peritonitis. However, further large – scale study should be performed to reclarify our findings.
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Bhat, Jehangir Allam, Sajad Ahmad Sheikh, and Roshan Ara. "Cord blood bilirubin, albumin, and bilirubin /albumin ratio for predicting subsequent neonatal hyperbilirubinemia." Paediatrica Indonesiana 59, no. 5 (2019): 244–51. http://dx.doi.org/10.14238/pi59.5.2019.244-51.
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Background Early discharge of healthy term newborns after delivery has become a common practice, because of medical and social reasons, as well as economic constraints. Thus, the recognition, follow-up, and early treatment of jaundice has become more difficult as a result of early discharge from the hospital. Since the dreaded complication of neonatal hyperbilirubinemia is kernicterus, an investigation which can predict the future onset of neonatal pathological jaundice is needed.
 Objective To investigate the predictability of neonatal hyperbilirubinemia by using cord blood bilirubin, albumin and bilirubin/albumin ratio.
 Methods This study was conducted on 300 healthy newborns. Umbilical cord blood was used to measure albumin and bilirubin. All infants were regularly followed up to 5th day of life. Neonates were divided into two groups: group A was consisted of neonates who developed jaundice which was in physiological range, while group B was consisted of neonates who developed neonatal hyperbilirubinemia (requiring phototherapy or other modality of treatment). Babies suspected to have bilirubin level which cross physiological limit on any day after birth were subjected to serum bilirubin measurement. Infants whose serum bilirubin level measurement revealed bilirubin levels crossing physiological values were sent to nursery for phototherapy.
 Results The incidence of neonatal hyperbilirubinemia was 11%. Statistically significant correlations between cord blood bilirubin, albumin, and bilirubin/albumin ratio to the development of neonatal hyperbilirubinemia were observed. On ROC analysis, cut-off points to predict significant hyperbilirubinemia in newborn were cord blood bilirubin >3 mg/dL (sensitivity 60.61%, specificity 97.63%), albumin <2.4 mg/dL (sensitivity 78.79%, specificity 98.13%), cord blood bilirubin/albumin ratio >0.98 (sensitivity 78.79%, specificity 95.51%).
 Conclusion Cord blood total bilirubin, albumin. and bilirubin/albumin ratio are excellent parameters to predict the occurrence of neonatal hyperbilirubinemia. However, cord blood albumin is better compared to cord blood bilirubin and bilirubin/albumin ratio.
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Sönmez, Mehmet Reşit, Elif Tuncay, İsa Caner Aydin, et al. "Prognostic importance of preoperative albumin-to-alkaline phosphatase ratio in colorectal cancer patients." Polish Journal of Surgery 96, no. 5 (2024): 1–5. http://dx.doi.org/10.5604/01.3001.0054.7078.
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Aim: This study aimed to evaluate the effect of the albumin-alkaline phosphatase ratio on prognosis of patients with colorectal cancer. Method: Data from 358 patients who had undergone surgery for colorectal cancer were analyzed retrospectively to identify factors that could predict overall survival. The Roc-Curve test was applied to determine the power of the preoperative albumin-alkaline phosphatase ratio in predicting mortality. Kaplan Meier and log-rank tests were used to examine the survival times of the patients. Results: Our findings revealed that an albumin-alkaline phosphatase cut-off ratio above 0.67 predicted mortality with a sensitivity of 17.54% and a specificity of 92.22%. Although patients with a lower albumin-alkaline phosphatase ratio exhibited a slightly shorter mean survival time compared to those above the cut-off value, this difference did not reach statistical significance (p=.112). Conclusion: The results of this study did not provide evidence to support the albumin-alkaline phosphatase ratio as a potential prognostic factor in patients with colorectal cancer.Keywords: albumin-alkaline phosphatase ratio, colorectal cancer, prognosis, biomarkers, surgery
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Afolayan, Odunayo, Michael Onigbinde, Victor Joel-Medewase, Oluwadare Oluwayemi, Olushola Oyedeji, and Samson Ojedokun. "Exploring bilirubin/albumin ratio as predictor of significant hyperbilirubinemia among neonate in Southwest Nigeria." International Journal of Contemporary Pediatrics 11, no. 8 (2024): 1021–26. http://dx.doi.org/10.18203/2349-3291.ijcp20242009.
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Background: The concept of prediction of neonatal hyperbilirubinemia offers an attractive option in identifying babies at risk of significant hyperbilirubinemia. This study determined the ability of the cord bilirubin/albumin ratio to predict significant hyperbilirubinemia. Methods: This was a hospital-based longitudinal cross-sectional study conducted on four hundred and seventy-one neonates in a southwest community in Nigeria. Blood samples were obtained for cord bilirubin, cord albumin and cord bilirubin/albumin ratio were analyzed for their predictive ability of significant hyperbilirubinemia at 72-96 hours with follow-up. Receiver observation curve analysis (ROC) was employed to compare the predictive abilities of cord bilirubin, cord albumin and cord bilirubin/albumin ratio. Results: The prevalence of significant hyperbilirubinemia was 4.2%. Cord bilirubin and cord bilirubin/albumin ratio were found to have a significant relationship with the development of significant hyperbilirubinemia at 48-72 hours follow-up. Cord bilirubin of greater than 1.58 mg/dl was shown to be predictive of significant hyperbilirubinemia with a sensitivity, specificity, negative predictive value, and positive predictive value of 70%, 48.34%, 5.7% and 97.3% respectively. Conclusions: Comparing the predictive abilities of cord bilirubin, cord albumin and cord bilirubin/albumin ratio; the study reveals that cord bilirubin has the best ability to predict significant hyperbilirubinemia.
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Shazia Hameed, Mahnoor Khan, and Shahjahan Ustrana. "Correlation of Urinary Gamma Glutamyl Transferase to Creatinine Ratio with Albumin Creatinine Ratio in Patients with Type 2 Diabetes Mellitus." Journal of Shalamar Medical & Dental College - JSHMDC 5, no. 1 (2024): 42–48. http://dx.doi.org/10.53685/jshmdc.v5i1.139.
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Background: Diabetic Nephropathy is one of the most serious outcomes of Diabetes Mellitus worldwide. As tubular injury precedes albuminuria, tubular enzyme Gamma Glutamyl Transferase (GGT) may serve as a more sensitive diagnostic biomarker for diabetic nephropathy. Objective: To determine and correlate urinary Gamma Glutamyl Transferase to creatinine ratio with urinary albumin creatinine ratio (uACR) in Type 2 diabetics based on gender. Methods: A cross-sectional study was undertaken at Shaikh Zayed Hospital from March 2022 to April 2023. A total of 100 male and female participants were included in this study. The study participants included 75 type 2 diabetics and 25 controls. The diabetic group was subdivided into normoalbuminuric and microalbuminuric based on urinary albumin creatinine ratio. All subjects' fasting blood glucose, urinary albumin, urinary creatinine, and urinary GGT levels were measured on the automated chemistry analyzer. The data was analyzed by SPSS version 24. “t-test” was used to compare the variables between different groups. The Pearson correlation test was used to establish the correlation between Gamma Glutamyl Transferase to creatinine ratio and uACR. Results: Urinary GGT (uGGT) levels were significantly higher in all type 2 diabetics as compared to controls (p <0.001). Both urinary albumin and uACR were raised in male diabetics (p<0.001) and female diabetics (p<0.005) as compared to controls, in male diabetics more increase was observed (p<0.001). A highly significant positive correlation was observed between uGGT:Creatinine ratio and uACR of all normoalbuminuric patients (‘r’ males=0.837 & females=0.919) and microalbuminuric patients (‘r’ males=0.600 & females=0.636) at p<0.001. Conclusion: Urinary Gamma Glutamyl Transferase to creatinine ratio is positively correlated with urinary albumin creatinine ratio and may serve as a more sensitive biomarker than urinary albumin creatinine ratio in diabetic patients with renal damage.
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Mohamed, Shereen A., and Rabab ElHawary. "C-Reactive Protein/Albumin Ratio as an Independent Predictor of Mortality in Critically Ill Pediatric Patients." Journal of Child Science 10, no. 01 (2020): e1-e11. http://dx.doi.org/10.1055/s-0040-1701623.
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AbstractIt is necessary to stratify the risk of pediatric patients at the time of intensive care unit (ICU) admission and to predict their outcomes. This helps to allocate the scarce ICU resources to start the appropriate treatment. The objective of this study was to evaluate the prognostic value of C-reactive protein/albumin ratio on admission to pediatric intensive care unit (PICU) in predicting mortality, PICU length of stay, the need for mechanical ventilation, and the use of inotropic drugs. This cohort study was conducted at Pediatric Cairo University Hospital. The study included 178 critically ill children. Pediatric Risk of Mortality–III (PRISM-III) score was calculated; CRP and serum albumin levels were assessed within 24 hours from admission. The median CRP/albumin ratio was significantly higher in nonsurvivors than survivors (18.60 and 4.65, respectively). The CRP/albumin ratio at a cutoff of ≥25.83 had significant discriminatory power in predicting mortality (area under the curve [AUC] = 0.795 and p < 0.001) with 85.4% accuracy. Furthermore, CRP/albumin ratio alone showed a comparable discriminatory power to that of PRISM-III score (AUCs = 0.795 and 0.793, respectively). A multivariable logistic regression analysis revealed that each unit of increase in the CRP/albumin ratio increased the risk of mortality by 1.075 (odds ratio [OR] = 1.075). CRP/albumin ratio showed a significantly higher median in ventilated (6.86) compared with non-ventilated (5.22) patients. Patients supported with inotropes showed significantly higher median CRP/albumin ratio (11.70 and 3.68, respectively). CRP/albumin ratio at admission to PICU was a good independent predictor of mortality.
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Lopa, AT, B. Rusli, M. Arif, and Hardjoeno Hardjoeno. "ANALISIS KADAR ALBUMIN SERUM DENGAN RASIO DE RITIS PADA PENDERITA HEPATITIS B." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 13, no. 2 (2018): 60. http://dx.doi.org/10.24293/ijcpml.v13i2.884.
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Hepatitis is a inflammation process which may present in an acute or chronic phase. A decrease of serum albumin level may befound in liver disease. Ratio de Ritis in mild hepatitis is < 1 while in alcoholic hepatitis is >1. To analyze serum albumin level withratio de Ritis in hepatitis B patients. A cross sectional study was carried out comprising 46 subjects from October 2005 to August 2006measuring albumin level SGOT and SGPT levels using Lyasis autoanalyzer. Thirty eight males and eight females, the level of serumalbumin decreased with an average of albumin level 2.98 gr/dL (p<0.05). Twenty two subjects showed a ratio de Ritis ≤ 1 with theaverage albumin level 3.00 gr/dL and 24 subjects were included in group ratio de Ritis > 1 with average albumin level 2.96 gr/dL(p value = 0.658). There was a decrease of serum albumin level in hepatitis B patient but no significant difference between decrease ofserum albumin level with ratio of de Ritis ≤ 1 and ratio of de Ritis >1.
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Yu, Jihion, Jun-Young Park, Seungsoo Ha, Jai-Hyun Hwang, and Young-Kug Kim. "C-reactive Protein/Albumin Ratio and Acute Kidney Injury after Radical Cystectomy among Elderly Patients: A Propensity Score-Matched Analysis." Disease Markers 2020 (October 27, 2020): 1–11. http://dx.doi.org/10.1155/2020/8818445.
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Background. The C-reactive protein (CRP)/albumin ratio is a useful index used to represent patient inflammation and nutritional status. Elderly patients are at the highest risk for acute kidney injury (AKI). We clarified the impact of the preoperative CRP/albumin ratio on AKI and evaluated the impact of postoperative AKI on end-stage renal disease (ESRD) among elderly cystectomy patients. Methods. We included elderly patients ≥ 65 years of age who underwent radical cystectomy. Multivariate logistic regression analysis and receiver operating characteristic curve analysis were performed to identify risk factors for AKI. Propensity score-matched analysis and conditional logistic regression analysis were performed to elucidate the impact of the CRP/albumin ratio on AKI. The incidence of ESRD was compared between the non-AKI and AKI groups at 12 months after radical cystectomy. Results. AKI occurred in 110 patients (32.2%). The CRP/albumin ratio and 6% hydroxyethyl starch amount were risk factors for postoperative AKI. The optimal cut-off value for the CRP/albumin ratio predicting AKI was 0.1. After propensity score matching, the AKI incidence in the CRP/albumin ratio ≥ 0.1 group was higher than that in the CRP/albumin ratio < 0.1 group (46.7% vs. 20.6%, P < 0.001 ), and a CRP/albumin ratio ≥ 0.1 was associated with a higher AKI incidence ( odds ratio = 4.111 , P < 0.001 ). The ESRD incidence was higher in the AKI group than in the non-AKI group (7.3% vs. 1.2%, P = 0.017 ). Conclusion. A CRP/albumin ratio ≥ 0.1 was associated with an increased incidence of AKI, which was associated with higher ESRD incidence among elderly cystectomy patients.
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Sonawane, Shreya, Maindad Gayatri C. Gawade, Meghana K. Padwal, et al. "Novel Inflammatory Score: C-Reactive Protein/Albumin Ratio in Pancreatitis." International Journal of Pharmaceutical and Clinical Research 15, no. 3 (2023): 422–37. https://doi.org/10.5281/zenodo.12697623.
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<strong>Background and Objectives:</strong> To prevent the complications in pancreatitis, identification of the biomarker at an early stage for screening and prognosis is the need of time. CRP is an easily detectable positive acute-phase protein. A negative acute-phase protein albumin is an indicator of nutritional status. Both independently can be used as prognostic markers. Based on these, combining inflammation and nutritional status<em>, </em>the novel inflammatory prognostic score CAR (CRP/albumin ratio), can be studied in the pancreatitis patients. We planned this study to evaluate the relationship between CAR, amylase, lipase and severity of pancreatitis. <strong>Objectives: </strong>(1) To associate CAR score and enzymatic biomarkers. (2) To classify pancreatitis based on pain in abdomen and its association with CAR. <strong>Observation and Results:</strong> The result of biochemical parameters like albumin, CRP, amylase, lipase was obtained after processing samples on autoanalyzer in 75 clinically diagnosed cases of pancreatitis. The correlation between the calculated ratio, CAR with biochemical parameters was done along with universal pain symptom severity score. The mean value of CAR was found as 2.204 mg/g. The mean age in yrs was 43.42 yrs, Pain score 0.96, CRP 64.55 mg/L, albumin 3.54 g/dl, amylase 292.468 U/L, lipase 512.36 U/L.CAR was positively correlated with age in yrs, CRP negatively correlated with albumin, amylase, lipase. CAR was found to be highly statistically significant with CRP and albumin with p value < 0.001. No statistically significant correlation between the universal pain score and CAR, serum albumin, serum amylase and serum lipase was found. <strong>Interpretation and Conclusion:</strong> CAR (CRP/albumin ratio) can be used as a novel, promising, easy, repeatable, cost effective, mathematical, inflammatory and comprehensive score as a predictive marker of pancreatitis severity before going for invasive and costly radiological investigations as it is derived from routinely done laboratory parameters.
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Tombokan, Vera D., Maxi M. L. Moleong, and Ageng I. Pratiwi. "Pengaruh Pemberian Ekstrak Propolis (HDI PropoelixTM) terhadap Rasio Albumin Kreatinin Urin Pasien DM Tipe II." Jurnal Biomedik:JBM 14, no. 1 (2022): 1. http://dx.doi.org/10.35790/jbm.v14i1.37321.
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Abstract: Examination of urine albumin to creatinine ratio can be performed to detect early signs of diabetic nephropathy, and this examination is easier to perform. The reference value used is the ratio of albumin to creatinine > 30 mg/g. Researches related to propolis and its benefits have been carried out for a long time. HDI Propoelix is a type of propolis extract using the CMCE (Continuous Multi-stage Countercurrent Extraction) method produced by PT Harmoni Dinamik Indonesia. HDI Propoelix has 7 bioactive components: CAPE (Caffeic Acid Phenethyl Ester), Narigenin, Chrysin, Galangin, Cinnamic Acid, Pinocembrin, Apigenin. These bioactive components amplify the health benefits of HDI Propoelix because these bioactive components are high in antioxidants, as well as have antidiabetic and nephroprotective properties. This study is a laboratory experimental study with a pretest-posttest with control group design, with 60 respondents who met the inclusion criteria. This study aimed to examine the effect of giving Propolis Extract (Propoelix) on the Urine Albumin to Creatinine Ratio in type II DM patients who have shown signs of diabetic nephropathy. The results obtained are that there is a significant effect in the experimental group given HDI Propoelix at a dose of 2x 200 mg for 90 days where there is a decrease in the urine albumin to creatinine ratio which was not found in the control group who was not given Propoelix.Keywords: diabetic nephropathy; urine albumin to creatinin ratio; propoolis ekstrak (propoelix) Abstrak: Pemeriksaan rasio albumin kreatinin urine sewaktu dapat dilakukan untuk mendeteksi tanda awal nefropati diabetik, dan pemeriksaan ini lebih mudah dilakukan. Nilai rujukan yang dipakai adalah rasio albumin kreatinin > 30 mg/g. Penelitian-penelitian terkait propolis dan manfaatnya telah dilakukan sejak lama. HDI PropoelixTM adalah salah satu jenis propolis Ekstrak metode CMCE (Continouis Multi-stage Countercurrent Extaction) yang di produksi oleh PT Harmoni Dinamik Indonesia. HDI PropoelixTM memiliki komponen bioaktif: CAPE (Caffeic Acid Phenethyl Ester), Narigenin, Chrysin, Galangin, Cinnamic Acid, Pinocembrin, Apigenin. Komponen bioaktif ini memperkuat manfaat kesehatan HDI Propoelix karena komponen bioaktif ini memiliki antioksidan yang tinggi ,dan bersifat antidiabetik dan nefroprotektor. Penelitian ini merupakan penelitian eksperimental laboratorik dengan rancangan penelitian pretest-posttest dengan kelompok kontrol, terhadap 60 responden yang memenuhi kriteria inklusi Penelitian ini bertujuan untuk melihat pengaruh pemberian Propolis Ekstrak (Propoelix) terhadap Rasio Albumin Kreatinin Urin pada pasien DM tipe II yang sudah menunjukkan tanda nefropati diabetik. Hasil penelitian yang diperoleh yaitu terdapat pengaruh yang signifikan pada kelompok eksperimen yang diberikan HDI Propoelix dengan dosis 2x 200 mg selama 90 hari dimana terdapat penurunan rasio albumin kreatinin urin yang tidak didapatkan pada kelompok kontrol yang tidak di berikan Propoelix. Kata kunci: nefropati diabetik; rasio albumin kreatinin urine; propolis ekstrak (propoelix)
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Iskandar, A., M. I. Vincentia, W. Jaya, A. Aryati, A. Pramadhani, and A. Aprilia. "The profile of lactate, albumin, and lactate/albumin ratio as predictors of mortality in sepsis patients." Russian Journal of Infection and Immunity 11, no. 6 (2021): 1095–100. http://dx.doi.org/10.15789/2220-7619-pol-1691.
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Background. Oxygenation disturbances in sepsis patients may cause lactate levels increase which is proportional to the severity of the inflammation, followed by decrease in albumin levels. Combination of these two parameters is expected to be predictor of mortality in patients with sepsis. The aim of this study is to investigate the profile of lactate, albumin, and lactate/albumin ratio as mortality predictors in patient with sepsis. Methods. This prospective cohort study was conducted in the ICU of dr. Saiful Anwar Hospital, Malang, from January to May 2019. Subjects were 82 patients with sepsis (SOFA score 2). Lactate and albumin levels were measured on the first day of hospitalization. Lactate levels were examined by colorimetric method, albumin was examined by BCG method. The instrument used was Cobas 501. Comparation was carried out using the T-Test/Mann–Whitney test. Prediction of mortality risk was done using relative risk (RR) determination. Results. Significant difference was observed in albumin levels between sepsis patients who survived and who died (p = 0.045). No significant differences were observed in lactate levels and lactate/albumin ratio between sepsis patients who survived and who died (p = 0.211, 0.119, respectively). Relative risks were 3.034 for lactate, 3.667 for albumin, and 4.400 for lactate/albumin ratio. Conclusion. In patients with sepsis, albumin level is the best variable in predicting mortality, followed by lactate/albumin ratio and lactate value. Further study that implements repeated measurement of lactate and albumin in 6 and 12 hours is required to better predict the mortality of sepsis patients.