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Journal articles on the topic 'Alchornea laxiflora'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

O. J., Ogunbiyi, Apata J. T., Jegede R. J., and Akinola F. T. "The Effects of Alchornea laxiflora Leaf Extract on Total- and HDL- Cholesterol Levels in Serum, Liver, and Kidney of Rats." Journal of Molecular Pharmaceuticals and Regulatory Affairs 4, no. 2 (2022): 15–19. http://dx.doi.org/10.46610/jmpra.2022.v04i02.003.

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Alchornea laxiflora is one of the underutilized tropical plants in Nigeria. The extract from the leaf has been shown to contain certain phytochemical principles which have been linked to some of its medicinal uses. The effect of Alchornea laxiflora aqueous leaf extract on the level of the total- and high-density lipoprotein (HDL) - cholesterols in the serum, liver, and kidney of rats was evaluated in this study. Twelve rats were grouped into three containing four each. Group A (control) was administered with only distilled water. Groups B and C were administered with aqueous extract of Alchorn

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Uhunmwangho, Esosa Samuel, Olajide Nurudeen Rasaq, and Onoriode Oyiborhoro. "Antioxidant Actions of Freshly Commuted Hexane Extracts of Alchornea Laxiflora Root on Sodium- Arsenate Induced Oxidative Stress in Male Wistar Rats." Research and Analysis Journal 4, no. 11 (2021): 21–25. http://dx.doi.org/10.18535/raj.v4i11.247.

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The antioxidant activities of hexane extract of freshly commuted roots (HR) of Alchornea laxiflora on liver damage were examined using in vivo sodium arsenate-induced oxidative damage model in male Wistar rats weighing between 150 and 200 g. The animals were grouped into two groups of four animals, group 1 animals were given 1ml of sodium-arsenate (2mg/kg) for 2 days and then treated with graded dosage (0.5, 1.0, 5.0 and 10.0 mg/kg body weight) HR of Alchornea laxiflora for 10days, while group 2 animals were given the same graded dosage HR extract of Alchornea laxiflora for 10 days but in addi

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3

Ogundipe, O. O., J. O. Moody, and P. J. Houghton. "Occurrence of Flavonol Sulphates in Alchornea laxiflora." Pharmaceutical Biology 39, no. 6 (2001): 421–23. http://dx.doi.org/10.1076/phbi.39.6.421.5888.

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4

Okokon, Jude E., Anwangabasi E. Udoh, Chinyelu Clementina Osigwe, Ugonma Florence Uwaeme, and Henry Thomas Okon. "Analgesic Activity of Alchornea laxiflora Stembark Extract in Mice." Asian Journal of Biochemistry, Genetics and Molecular Biology 17, no. 6 (2025): 22–29. https://doi.org/10.9734/ajbgmb/2025/v17i6470.

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Alchornea laxiflora is used in Ibibio ethnomedicine for the treatment of various diseases such as pains. This work was designed to validate and confirm the ethnomedical use of this plant in the treatment of pain. The ethanol stembark extract of Alchornea laxiflora (141-424 mg/kg) was evaluated for analgesic activity against experimentally-induced pains in mice using acetic acid-induced writhing, formalin-induced hind paw licking and thermally-induced pain models. The stembark extract significantly (p<0.005-0.001) inhibited pains in all the models tested in a dose-dependent manner. The extra

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5

Jain, Nem Kumar, Balakumar Chandrasekaran, Nasha’t Khazaleh, et al. "Computational Network Pharmacology, Molecular Docking, and Molecular Dynamics to Decipher Natural Compounds of Alchornea laxiflora for Liver Cancer Chemotherapy." Pharmaceuticals 18, no. 4 (2025): 508. https://doi.org/10.3390/ph18040508.

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Background: Alchornea laxiflora (Benth.) Pax & K. Hoffm. (A. laxiflora) is utilized as a traditional herb for treating several diseases. Objective: Our study aims to identify the active phytochemical candidates from A. laxiflora and analyses to predict their anticancer activity mechanism by employing network pharmacology, molecular docking, and molecular dynamics (MD). Methods: The phytoconstituents of A. laxiflora were retrieved from the literature, and phytoconstituent-related targets implicated in hepatocellular carcinoma (HCC) were collected from respective databases. Computational met

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K. Oloyede, Ganiyat, Patricia A. Onocha, Oluwatosin A. Adaramo, and S. Emmanuel Thonda. "Hepatoprotective Activity and Flavonoids of Alchornea laxiflora Leaf Extract." Research Journal of Phytochemistry 5, no. 4 (2011): 190–200. http://dx.doi.org/10.3923/rjphyto.2011.190.200.

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7

Durojaye, Catherine, Olusola Elekofehinti, Innocent Osho, and Stephen Abodunrin. "Alchornea laxiflora as therapeutic agent in the treatment of Trypanosoma brucei brucei infection using experimental wistar rats; invivo and gene expression studies." Journal of Research in Veterinary Sciences 1, no. 1 (2023): 27. http://dx.doi.org/10.5455/jrvs.20230812093455.

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Aims: African trypanosomosis is a zoonotic tropical disease of Sub-Saharan Africa. Its etiology is a group of extracellular protozoans of the genera Trypanosoma which has numerous species including Trypanosoma brucei brucei. Inavailability of vaccines and numerous side effects arising from few available antitrypanosomal drugs gives the indication for search for local alternatives. This experimental study investigates the antitrypanosomal efficacy of chloroform extract of A. laxiflora leaves in wistar albino rats infected with Trypanosoma brucei brucei. Place and Duration of Study: Animal Paras

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8

Nwonu, Chukwunwike, Olapade Ilesanmi, Joseph Agbedahunsi, and Patience Nwonu. "Analgesic Profile of the Aqueous and Methanol Extracts of Alchornea Laxiflora in Albino Mice." European Scientific Journal, ESJ 14, no. 24 (2018): 134. http://dx.doi.org/10.19044/esj.2018.v14n24p134.

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The study investigated the median lethal dose and the effects of the aqueous and methanol extracts of Alchornea laxiflora in three mouse models of central and peripheral analgesia, the hot plate, acetic acid-induced abdominal writhes and the tail immersion tests. This was with a view to providing information on the acute toxicity, analgesic effects and the possible mechanism of analgesia. The LD50 for the aqueous and methanol extracts of A. laxiflora in the oral route was > 1600 mg/kg respectively, and found to be safe in animals. However, the LD50 (i.p.), was found to be 400 mg/kg for the

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9

Okokon, Jude E., Aniedi U. Obot, Dinesh Mohanakrishnan, Garima Mittal, and Dinkar Sahal. "Antimalarial and Antiplasmodial Activity of Leaf Extract of Alchornea laxiflora." Journal of Herbs, Spices & Medicinal Plants 23, no. 2 (2017): 128–41. http://dx.doi.org/10.1080/10496475.2016.1275072.

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10

Ogundipe, O. O., J. O. Moody, P. J. Houghton, and H. A. Odelola. "Bioactive chemical constituents from Alchornea laxiflora (benth) pax and hoffman." Journal of Ethnopharmacology 74, no. 3 (2001): 275–80. http://dx.doi.org/10.1016/s0378-8741(00)00352-4.

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11

Okokon, Jude E., Nkemnele Bensella Augustine, and Dinesh Mohanakrishnan. "Antimalarial, antiplasmodial and analgesic activities of root extract of Alchornea laxiflora." Pharmaceutical Biology 55, no. 1 (2017): 1022–31. http://dx.doi.org/10.1080/13880209.2017.1285947.

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12

O., J. Osabiya, O. Bada S., O. Ibitoye F., and K. Aribisala O. "Assessment of Phytochemical Constituent, Antibacterial and Cytotoxic Activities of A. laxiflora (Ewe pepe) Extracts." Journal of Applied Life Sciences International 12, no. 2 (2017): 1–9. https://doi.org/10.9734/JALSI/2017/34038.

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<strong>Aim: </strong>This study was done to determine the phytochemical constituents, antibacterial and cytotoxic activities of leaf extracts of <em>A. laxiflora </em>(“ewe pepe”). <strong>Place and Duration of Study:</strong> Department of Science Laboratory Technology (Microbiology and Analytical Chemistry Laboratories), Rufus Giwa Polytechnic, Owo, Nigeria, between August 2016 and March 2017. <strong>Methodology:</strong> The methods used include manual grinding of the air-dried leaves and solvent (aqueous and ethanol) percolation for 72 hrs. The resultant crude extracts were kept in steri

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Yusuf, K. O., O. A. Isah, O. M. Arigbede, A. O. Oni, and C. F. I. Onwuka. "Chemical composition, secondary metabolites, in vitro gas production characteristics and acceptability study of some forage for ruminant feeding in South-Western Nigeria." Nigerian Journal of Animal Production 40, no. 1 (2020): 179–90. http://dx.doi.org/10.51791/njap.v40i1.693.

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Studies were conducted to evaluate the nutritive value of eight selected forages (Tridax procumbens, Merremia aegyptia, Aspilia africana, Tithonia diversifolia, Alchornea cordifolia, Alchornea laxiflora, Synedrella nodiflora, and Newbouldia laevis) consumed by ruminants in South-Western Nigeria. Chemical composition and qualitative analysis of saponins, phenol and steroids of the plants were determined. In vitro gas production (IVGP) was carried out for 72 hours on the plants. Metabolizable energy (ME), Organic matter digestibility (OMD) and Short chain fatty acids (SCFA) were predicted and me

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14

Sandjo, Louis Pergaud, Hervé M. Poumale Poumale, Xavier Noudou Siwe, et al. "Two New Fatty Acid Derivatives from the Stem Bark of Alchornea laxiflora (Euphorbiaceae)." Journal of the American Oil Chemists' Society 88, no. 8 (2011): 1153–59. http://dx.doi.org/10.1007/s11746-011-1770-7.

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15

Sandjo, Louis Pergaud, Hervé M. Poumale Poumale, Xavier Siwe Noudou, et al. "Erratum to: Two New Fatty Acid Derivatives from the Stem Bark of Alchornea laxiflora (Euphorbiaceae)." Journal of the American Oil Chemists' Society 88, no. 11 (2011): 1849. http://dx.doi.org/10.1007/s11746-011-1890-0.

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16

Akinpelu, David A., Emmanuel O. Abioye, Olayinka A. Aiyegoro, Oluseun F. Akinpelu, and Anthony I. Okoh. "Evaluation of Antibacterial and Antifungal Properties ofAlchornea laxiflora(Benth.) Pax. & Hoffman." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/684839.

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Alchornea laxifloraleaf extract was tested against a range of microorganisms using standard microbiological methods for antimicrobial activities. The extract inhibited the growth of all the bacterial and 15 fungal isolates tested. The zones of inhibition exhibited against the test bacteria ranged between 12 mm and 24 mm and between 11 mm and 24 mm for the extract and the antibiotic streptomycin, respectively. The zones of inhibition observed against the fungal isolates by the extract ranged between 12 mm and 23 mm. The minimum inhibitory concentrations (MICs) and the minimum bactericidal conce

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17

Olajire, A. A., G. O. Adeyeye, and R. A. Yusuf. "Alchornea laxiflora Bark Extract Assisted Green Synthesis of Platinum Nanoparticles for Oxidative Desulphurization of Model Oil." Journal of Cluster Science 28, no. 3 (2017): 1565–78. http://dx.doi.org/10.1007/s10876-017-1167-3.

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18

ALEBIOSU, Olugbenga Shadrak, and Olusola H. ADEKANMBI. "A Survey of Atmospheric Pollen and Spores in North-Western Nigeria." Notulae Scientia Biologicae 10, no. 2 (2018): 182–92. http://dx.doi.org/10.15835/nsb10210251.

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The incidence of airborne pollen occurring as aeroallergens of varied levels at different periods of the year has generated some public health concern globally. The present study was conducted in order to examine the monthly depositional rate of airborne pollen and fern spores, as well as the impact of meteorological parameters and local plants on pollen distribution at two study sites in Kaduna and Sokoto States of North Western Nigeria. The study spanned a period of one year, during which a modified Tauber pollen sampler was employed in the collection of atmospheric pollen and fern spores; l

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19

Rasaq, NurudeenOlajide, EsosaSamuel Uhunmwangho, and IyanuoluwaOlubukola Osikoya. "Hepatoprotective effects of hexane root extract of Alchornea laxiflora in sodium arsenate toxicity in wistar albino rats." CHRISMED Journal of Health and Research 5, no. 1 (2018): 38. http://dx.doi.org/10.4103/cjhr.cjhr_33_17.

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20

Siwe-Noundou, X., D. T. Ndinteh, D. K. Olivier, et al. "Biological activity of plant extracts and isolated compounds from Alchornea laxiflora: Anti-HIV, antibacterial and cytotoxicity evaluation." South African Journal of Botany 122 (May 2019): 498–503. http://dx.doi.org/10.1016/j.sajb.2018.08.010.

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21

Bada, S., A. Oyetayo, K. Adaramola-Ajibola, and E. Giwa. "A Preliminary Study of the Effect of Alchornea laxiflora on Haematological Parameters and Organ Weight in Albino Rats." International Blood Research & Reviews 7, no. 3 (2017): 1–6. http://dx.doi.org/10.9734/ibrr/2017/35722.

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22

Ekennia, Anthony, Dickson Uduagwu, Olawale Olowu, et al. "Biosynthesis of zinc oxide nanoparticles using leaf extracts of Alchornea laxiflora and its tyrosinase inhibition and catalytic studies." Micron 141 (February 2021): 102964. http://dx.doi.org/10.1016/j.micron.2020.102964.

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23

Watcho, Pierre, Vanessa Wandja, Esther Ngadjui, et al. "Evidence-based in vivo tocolytic activities of Alchornea laxiflora (Benth) (Euphorbiaceae) in female rats." Cameroon Journal of Experimental Biology 11, no. 1 (2019): 70. http://dx.doi.org/10.4314/cajeb.v11i1.9.

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24

Osineye, S. O., H. O. B. Oloyede, and T. O. Uthman. "Allelopathic effects of Alchornea laxiflora (Benth.) Pax & K Hoffm. leaves on seed germination and seedling growth of tomato." Allelopathy Journal 54, no. 1 (2021): 61–70. http://dx.doi.org/10.26651/allelo.j/2021-54-1-1348.

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25

Uhunmwangho, E., N. Rasaq, and O. Ojemekele. "Protective Effect of Alchornea laxiflora Methanolic Leaf Extract on CCL4-induced Hepatotoxicity and Reproductive Toxicity in Male Wistar Rats." British Journal of Pharmaceutical Research 14, no. 1 (2016): 1–7. http://dx.doi.org/10.9734/bjpr/2016/29807.

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26

Moucharou Ngnignigniwou, Jonathan, Junior Baudoin Wouokoue Taffo, and Victor François Nguetsop. "Woody species diversity and ecological characteristics of the Mawouon forest, in the Western Highlands of Cameroon." Cameroon Journal of Experimental Biology 15, no. 1 (2022): 28–34. http://dx.doi.org/10.4314/cajeb.v15i1.5.

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This study was conducted to characterize the floristic, structural and ecological diversity of the Mawouon Forest in the Noun division (Western Highlands Cameroon). In total, 14 plots of 30 m x 100 m (3000 m²) were laid out. Within each, all individuals with a diameter ≥ 10 cm at 1.30 m in height were measured. A total of 2324 individuals belonging to 102 species, 78 genera and 35 families have been identified. The richest family was the Fabaceae (15 species) followed by Euphorbiaceae (12 species) and Moraceae (10 species). The most abundant family was the Rubiaceae (26.97%) followed by Euphor

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Esosa, Uhunmwangho S., Omage Kingsley, Erifeta O. Georgina, Josiah J. Sunday, and Nwangwu C. O. Spencer. "Possible Reversal of Sodium Arsenate-induced Liver Toxicity by Hexane Leaf Extract of Alchornea laxiflora<.em>." Asian Journal of Medical Sciences 5, no. 1 (2013): 03–08. http://dx.doi.org/10.19026/ajms.5.5339.

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Olajire, A. A., N. F. Ifediora, M. D. Bello, and N. U. Benson. "Green Synthesis of Copper Nanoparticles Using Alchornea laxiflora Leaf Extract and Their Catalytic Application for Oxidative Desulphurization of Model Oil." Iranian Journal of Science and Technology, Transactions A: Science 42, no. 4 (2017): 1935–46. http://dx.doi.org/10.1007/s40995-017-0404-9.

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UWAYA, DICKSON. "Antidepressant, antianxiolytic and antiepileptic effects of Mojeaga herbal remedy<sup>®</sup>in albino miceRaymond." Journal of Current Biomedical Research 5, no. 3, May-June (2025): 2080–101. https://doi.org/10.54117/bj2j9921.

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The Mojeaga herbal remedy is made up of several herbs, including Alchornea laxiflora, Pennisetum purpureum, and Sorghum bicolour. It is primarily used to treat anaemia, boost immune system function, and provide antioxidant effects. The aim of this work is to investigate the antidepressant, anti-epileptic, and anxiolytic effects of the Mojeaga herbal remedy®. The forced swim test and the tail suspension test in mice were employed to examine the antidepressant effect. Pentylenetetrazol and strychnine-induced seizure models were used to assess the anti-epileptic activity, while the elevated plus

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AGBOOLA, Oludare Oladipo, Olalekan Oluwatoyosi SALAMI, and Stephen OYEDEJI. "Biodiversity Status of the Immediate Vicinity of an Iron and Steel Recycling Factory in Ile-Ife, South-Western Nigeria." Notulae Scientia Biologicae 7, no. 1 (2015): 45–51. http://dx.doi.org/10.15835/nsb719420.

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Floristic composition of vegetation communities of 27 plots established along a line transect in the four major directions was investigated in the vicinity of an Iron and Steel factory in Ile-Ife, Nigeria. The aim of the study was to document the plant species composition (biodiversity) of the plant communities found within the 350 m perimeter of the facility in the study area, which will serve as a reference data, as there was no reported study for the area prior to the establishment of the factory. Plant species were identified to species level in a 10 x 10 m plot and the occurrence of each

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Tchinda, Cedric F., Igor K. Voukeng, Veronique P. Beng, and Victor Kuete. "Antibacterial activities of the methanol extracts of Albizia adianthifolia , Alchornea laxiflora , Laportea ovalifolia and three other Cameroonian plants against multi-drug resistant Gram-negative bacteria." Saudi Journal of Biological Sciences 24, no. 4 (2017): 950–55. http://dx.doi.org/10.1016/j.sjbs.2016.01.033.

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32

Lawrence Adebayo, Oluwafemi, Emmanuel Folorunso Olasehinde, Labunmi Lajide, Daniel Oloruntoba, and Morenike Grace Ajayi Oloruntoba. "Studies on Thermal Stability, Shelf Life and Electrochemical Measurement of Methanol Extract of Air Dried <i>Alchornea Laxiflora</i> Leaves in Corrosion Prevention." American Journal of Materials Synthesis and Processing 4, no. 2 (2019): 68. http://dx.doi.org/10.11648/j.ajmsp.20190402.13.

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Osuntokun, OludareTemitope, and Thonda OA. "Comparative Study of the Antibacterial and antifungal Spectrum, Phytochemical screening and Antioxidant potentials of Alchornea laxiofolia and Piliostigma reticulatum Leaf on Pathogenic Isolates." Pharmaceutical and Chemical Journal 3, no. 2 (2016): 1–11. https://doi.org/10.5281/zenodo.13742397.

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<em>Piliostigma reticulatum</em> plant found in West Africa. It is an Evergreen shrub with a twisted bole to 9 m high, with a bushy spherical canopy. Bark dark grey to brown, fibrous and corky, slash dark red. Leaves large, thick, leathery, grey-green, 6-12 cm long, Fruit large, long, straight, undulate or twisted and hard, either glabrous or sparsely pubescent, brown, indehiscent, up to 25 cm long, 5 cm wide. <em>Alchonea laxiofolia</em> is a Deciduous, erect to straggling shrub 7m tall. Two extracting solvents were used for purpose of extraction, (Ethanol and Aqueous). Six clinical and envir

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Oluwafemi Lawrence, Adebayo, Emmanuel Folorunso Olasehinde, Labunmi Lajide, and Daniel Oloruntoba. "Effect of Drying Method on Phytochemical Compositions and Inhibition Efficiency of <i>Alchornea Laxiflora</i> and <i>Mucuna Flagellepes</i> Leaves Extracts in Corrosion Prevention." American Journal of Physical Chemistry 8, no. 2 (2019): 32. http://dx.doi.org/10.11648/j.ajpc.20190802.11.

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Agbedahunsi, J. M., C. A. Elusiyan, M. C. Cyril-Olutayo, et al. "Antisickling activity-guided fractionation of some plants used for the management of sickle cell disease in southwest Nigeria." Nigerian Journal of Natural Products and Medicine 26, no. 1 (2023): 42–55. http://dx.doi.org/10.4314/njnpm.v26i1.6.

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The study evaluated the antisickling activities of some plants used in the Southwestern Nigeria ethno-medicine for the management of sickle cell disease (SCD), with a view to determining the most active plant extract and fraction. A semi-structured questionnaire was administered to two hundred and ten (210) respondents, which comprised traditional medical practitioners, herb sellers and community elders. Aqueous extracts of the plants with high fidelity levels alongside the positive controls (vanillic acid and p-hydroxybenzoic acid) were tested in vitro against the sickled erythrocytes, using

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Ashvin, G. Godghate, Shivaji Patil Rahul, and S. Sawant Rajaram. "Screening of Secondary Metabolites and Antibacterial Activity of Some Indian Spices." Biolife 3, no. 3 (2022): 614–19. https://doi.org/10.5281/zenodo.7294158.

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ABSTRACT      Current research work deals with screening of secondary metabolites and antibacterial potential of <em>Rhizoma zingiberis, Cuminum cyminum</em> L., <em>Curcuma longa </em>L., <em>Piper nigrum </em>L. and <em>Cinnamomum tamala</em>  the Indian spices. Ethanol and water were used for preparation of test extracts. The present Indian spices found rich in secondary metabolites and shown presence of significant antimicrobial properties. The ethanolic extract of <em>Curcuma longa, </em>aqueous extract of <em>Cuminum cyminum, Cinnamomum tamala </em>and<em> Piper

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"Alchornea laxiflora." CABI Compendium CABI Compendium (January 7, 2022). http://dx.doi.org/10.1079/cabicompendium.4075.

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38

"Essential oil of Alchornea laxiflora (benth): phytochemical, antimicrobial and toxicity evaluations." Letters in Applied NanoBioScience 8, no. 3 (2019): 661–65. http://dx.doi.org/10.33263/lianbs83.661665.

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Alchornea laxiflora belonging to the Euphorbiaceae family has ethnomedicinal applications as antimalarial, anti-inflammatory, and anti-microbial agent. This present study investigated the spectroscopic, antibacterial, and toxicity profile of essential oil of Alchornea laxiflora (ALEO). The composition of ALEO was detected using Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier Transform Infrared (FTIR) Spectroscopy. Using agar disc diffusion, the antibacterial activity of ALEO against five clinical isolates: Bacillus subtilis ATCC 6633, Bacillus cereus ATCC 10872, Escherichia coli ATCC

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Bafor, Enitome E., Juliet K. Nwogu, Uloma B. Elvis-Offiah, et al. "Modulation of ex-vivo uterine contraction by the methanol leaf extract of Alchornea laxiflora Benth. (Euphorbiaceae) and preliminary spectrometric identification of associated secondary metabolites." Journal of Medicinal Plants for Economic Development 2, no. 1 (2018). http://dx.doi.org/10.4102/jomped.v2i1.33.

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Background: The leaves of Alchornea laxiflora are traditionally used in the south of Nigeria to prevent preterm births. Aim: This study was designed to investigate the activity of A. laxiflora on uterine contractility. Setting: The leaves of the plant were collected from forests in Egor, Benin City, Nigeria. Methods: The leaves were cleaned and extracted in methanol. The extract (0.005 mg/mL–3.5 mg/mL) was tested on spontaneous uterine contraction and on oxytocin-induced contraction in normal and Ca2+-free media. The plant extract (0.0035 mg/mL, 0.035 mg/mL, 0.35 mg/mL and 3.5 mg/mL) was teste

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40

Jain, Nem Kumar, Mukul Tailang, Santosh Kumar, et al. "Appraising the therapeutical potentials of Alchornea laxiflora (Benth.) Pax & K. Hoffm., an underexplored medicinal herb: A systematic review." Frontiers in Pharmacology 13 (December 2, 2022). http://dx.doi.org/10.3389/fphar.2022.958453.

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Ethnopharmacological relevance:Alchornea laxiflora (Benth.) Pax &amp; K. Hoffm. (Euphorbiaceae) is an important traditional medicinal plant grown in tropical Africa. The stem, leaves, and root have been widely used in the folk medicine systems in Nigeria, Cameroon, South Africa, and Ghana to treat various ailments, including inflammatory, infectious, and central nervous system disorders, such as anxiety and epilepsy.Material and methods: The scientific name of the plant was validated using the “The Plant List,” “Kew Royal Botanic Gardens,” and Tropicos Nomenclatural databases. The literatu

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Jain, Nem Kumar, Mukul Tailang, Balakumar Chandrasekaran, et al. "Integrating network pharmacology with molecular docking to rationalize the ethnomedicinal use of Alchornea laxiflora (Benth.) Pax & K. Hoffm. for efficient treatment of depression." Frontiers in Pharmacology 15 (March 5, 2024). http://dx.doi.org/10.3389/fphar.2024.1290398.

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Background: Alchornea laxiflora (Benth.) Pax &amp; K. Hoffm. (A. laxiflora) has been indicated in traditional medicine to treat depression. However, scientific rationalization is still lacking. Hence, this study aimed to investigate the antidepressant potential of A. laxiflora using network pharmacology and molecular docking analysis.Materials and methods: The active compounds and potential targets of A. laxiflora and depression-related targets were retrieved from public databases, such as PubMed, PubChem, DisGeNET, GeneCards, OMIM, SwissTargetprediction, BindingDB, STRING, and DAVID. Esse

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Oluyemi, Omoya, Funmilola, and Oloruntuyi, Adedayo Blessing. "Prophylactic and Curative Potency of Alchornea laxiflora Extract on Plasmodium berghei Infected Swiss Albino Mice." International Journal of TROPICAL DISEASE & Health, May 8, 2019, 1–11. http://dx.doi.org/10.9734/ijtdh/2019/v36i130134.

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Background: Malaria is one of the most important infectious diseases in Nigeria and in Africa at large as everyone is at risk of the infection. Objectives: This study was carried out to evaluate the antiplasmodial activity of Alchornea laxiflora leaf extracts against Plasmodium berghei infected mice. Materials and Methods: In vivo antimalarial assay on chloroquine-sensitive P. berghei-infected mice was carried out by oral administration of graded doses (200 mg/kg, 400 mg/kg and 600 mg/kg) of methanolic and chloroform extracts using chloroquine and distilled water as positive and ne

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Nwonu, Chukwunwike, Olapade Ilesanmi, Joseph Agbedahunsi, and Patience Nwonu. "Neuromuscular Inhibitory Effects of the Aqueous and Methanol Extracts of Alchornea laxiflora in Adult Albino Mice." International Journal of Scientific and Research Publications (IJSRP) 8, no. 5 (2018). http://dx.doi.org/10.29322/ijsrp.8.5.2018.p7781.

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Olanrewaju, Esan Oluwaseun, Igado Olumayowa Olawumi, Femi-Akinlosotu Omowumi Moromoke, et al. "ALCHORNEA LAXIFLORA (BENTH.) PAX & K. HOFFMAN EXTRACT PROTECTS AGAINST LEAD-INDUCED NEURODEGENERATION IN COCKEREL CHICKENS." IBRO Neuroscience Reports, June 2024. http://dx.doi.org/10.1016/j.ibneur.2024.06.004.

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Ekennia, Anthony C., Dickson N. Uduagwu, Njemuwa N. Nwaji, et al. "Facile green synthesis and biological evaluation of biogenic silver nanoparticles using aqueous extract of Alchornea laxiflora leaf." Inorganic and Nano-Metal Chemistry, January 10, 2022, 1–12. http://dx.doi.org/10.1080/24701556.2021.2025398.

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Olawuwo, Olasunkanmi S., Ibukun M. Famuyide, and Lyndy J. McGaw. "Antibacterial and Antibiofilm Activity of Selected Medicinal Plant Leaf Extracts Against Pathogens Implicated in Poultry Diseases." Frontiers in Veterinary Science 9 (March 2, 2022). http://dx.doi.org/10.3389/fvets.2022.820304.

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Antimicrobial resistant poultry pathogens are responsible for treatment failure and economic losses, and can also be a source of resistant zoonotic infections representing a risk to human health. In 2006 the European Union banned the use of antibiotics as growth promoters in farm animals and other regions are likely to follow suit. Alternative products and strategies are sought to help maintain animal gut health to reduce the prevalence of pathogens in the food chain. The minimum inhibitory concentration (MIC) of organic and aqueous leaf extracts of Alchornea laxiflora, Ficus exasperata, Morin

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