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Journal articles on the topic 'Alcoholic hepatosis'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

K. O. Gerasymenko. "Forensic medical diagnosis of alcoholic encephalopathy." Bukovinian Medical Herald 17, no. 3 (67) p.1 (2013): 40–41. http://dx.doi.org/10.24061/2413-0737.xvii.3.67.2013.123.

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2

Sirchak, E. S., V. I. Griga, Yo I. Pichkar, and N. Yu Kurchak. "Disbiotic changes in patients with non-alcoholic fatty liver disease." Medical alphabet 4, no. 38 (2020): 44–47. http://dx.doi.org/10.33667/2078-5631-2019-4-38(413)-44-47.

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The results of study at 96 patients with non-alcoholic fatty liver disease are presented. A high incidence of intestinal microbiome disorders was observed in the examined patients, especially at the stage of non-alcoholic steatohepatitis. The relationship between the persistence of impaired lipid metabolism and the degree of dysbiosis of the colon, namely between grade II dysbiosis and the level of total cholesterol in patients with non-alcoholic fatty hepatosis (r = 0.77; p < 0.01), and grade III dysbiosis and total cholesterol, triglycerides in patients with non-alcoholic fatty steatohepa

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3

Orlova, S. V., A. N. Vodolazkaya, O. I. Tarasova, et al. "Phytonutrients in complex diet therapy for alcoholic liver disease and non-alcoholic fatty liver disease." Medical alphabet, no. 16 (September 5, 2024): 13–18. http://dx.doi.org/10.33667/2078-5631-2024-16-13-18.

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Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are serious health problems with different epidemiological profiles. The long-term goal of treating chronic hepatosis is to prevent the progression of cirrhosis and/or liver cancer and prolong survival and patient’s quality of life. Herbal supplements containing medicinal plants, such as milk thistle, triphala, ginger and plants of the genus Phyllanthus, have great potential in optimizing the therapeutic effect in such patients.

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MALYAVSKAYA, S. I., A. V. LEBEDEV, G. N. KOSTROVA, V. A. FOKINA, and V. A. SEMENOV. "Metabolic atherogenic disorders in adolescents with fatty hepatosis." Practical medicine 19, no. 5 (2021): 63–66. http://dx.doi.org/10.32000/2072-1757-2021-5-63-66.

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To determine the features of disorders and the relationship of the blood lipid spectrum, indicators of peroxidation and insulin resistance in adolescents with fatty hepatosis, a single-stage study was conducted of a sample of 58 adolescents from Arkhangelsk aged 16–17 y. o. who have instrumental signs of fatty hepatosis according to ultrasound diagnostics. The comparison group consisted of 219 adolescents from Arkhangelsk who did not have acute and chronic diseases at the time of the examination. The results of the study showed higher average values of total lipid peroxidation, HOMA index, ins

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Denefil, O. "The rates of middle molecules in the blood in rats with different motor activity in alcoholic and non alcoholic exerimental hepatosis." Journal of Education, Health and Sport 11, no. 12 (2021): 385–95. http://dx.doi.org/10.12775/jehs.2021.11.12.032.

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Alcohol use disorders affect millions of individuals worldwide. The impact of these facts lies in the elevated social and economic costs. Liver metabolizes 75-98 % of ethanol that enters the organism. If the level of alcohol in the liver cells exceeds its degradation rate, alcoholic liver disease develops. The aim of the study was to determine the peculiarities of hepatotoxicity after simulation of of ethanol hepatosis and non-alcoholic steatohepatitis of high and low-motor active rats. Material and methods of investigation. The experiments were performed on on 72 white outbred mal

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ВABOV, Konstantin, Sergеy GUSHCHA, Khrystyna KOIEVA, et al. "Comparative assessment of biological activity of peloids of Ukraine of different genesis." Balneo Research Journal, Vol.11, no.4 (December 5, 2020): 467–71. http://dx.doi.org/10.12680/balneo.2020.380.

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The article presents the results of comprehensive studies of the influence of peloids from different geographic regions of Ukraine and different genesis on the course of experimental pathology. Methods:At the first stage of research we have determined the type of peloids these are medium-mineralized weakly sulfide magnesium-sodium silt peloids, low-ash organic sapropels, and peat low-mineralized high-ash sulfide-free peloids. Physicochemical parameters have been established: mass fraction of moisture, volumetric weight, hydrogen sulfide content, contamination with particles with a diameter gre

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Pavlovskyi, S. A. "Efficiency of treatment of patients with non-alcoholic steatohepatitis combined with diabetes mellitus type 2 using the s-adenosylmethionin." Reports of Vinnytsia National Medical University 22, no. 1 (2018): 198–202. http://dx.doi.org/10.31393/reports-vnmedical-2018-22(1)-38.

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Non-alcoholic fatty liver disease is an important cause of chronic liver damage in many countries and is growing rapidly in both adults and children due to obesity and diabetes type 2. Aim — investigate the effectiveness of complex treatment of patients for the course of NASH using S-adenosylmethionin on the background of basic therapy. The study included 25 patients with non-alcoholic steatohepatitis against type 2 diabetes, age on average (58.69±1.25) years. The control group comprised 15 healthy individuals. In order to identify the diagnosis, data from clinical and laboratory, biochemical

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Matkevich, E. I., A. N. Bashkov, E. A. Ionova, et al. "Modern Possibilities of Imaging Diagnosis Methods in Assessing the Severity of Fatty Hepatosis in Non-Alcoholic Fatty Liver Disease (Clinical Case)." MEDICAL RADIOLOGY AND RADIATION SAFETY 68, no. 6 (2023): 73–79. http://dx.doi.org/10.33266/1024-6177-2023-68-6-73-79.

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Purpose: To estimate the potential of imaging methods in the diagnosis of non-alcoholic fatty liver disease (NAFLD) based on the example of a clinical case. Material and methods: A 42 years-old man with suspected of NAFLD, by the clinical and laboratory tests results, underwent a quantitative assessment of fatty hepatosis using radiodiagnosis imaging methods. We used US “liver protocol” with attenuation imaging technique (ATI), shear wave elastography (SWE), shear wave dispersion imaging (SWD), computed tomography (CT) with quantitative and qualitative assessment using the liver-spleen index (

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Yuldasheva, D.X. Muzaffarova N.S. "ASSESSMENT OF THE DEVELOPMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE BY CLINICAL AND LABORATORY MARKERS." INTERNATIONAL BULLETIN OF MEDICAL SCIENCES AND CLINICAL RESEARCH 3, no. 5 (2023): 57–60. https://doi.org/10.5281/zenodo.7912658.

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Currently, non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases in hepatology, leading to a deterioration in the quality of life, disability and death. The overall prevalence of NAFLD in the population ranges from 10 to 40% [1,3,5,6,7]. In the normal course of NAFLD, 12-40% of patients with hepatosis develop non-alcoholic steatohepatitis after 8-13 years. Of these, 15% of patients develop liver cirrhosis and liver failure. Of 7% of patients with liver cirrhosis, hepatocellular carcinoma develops within 10 years [2,3,5]. The heterogeneity of NAFLD leads to the absence of

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Rashidova, Khurshida A. "Ultrasonic elastographic and morphological features of fatty hepatosis." Digital Diagnostics 4, no. 1S (2023): 111–12. http://dx.doi.org/10.17816/dd430362.

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BACKGROUND: Non-alcoholic fatty liver disease is a common chronic liver condition characterized by pathological accumulation of fatty droplets, which is not associated with alcohol consumption. The main reason in the development of complications and adverse outcomes of the disease is fibrotic changes in the liver, leading to cirrhosis. AIM: To determ the informative value of two-dimensional shear wave elastography in hepatosis by a comparative analysis of morphological and ultrasound elastometric findings. METHODS: The study included 40 patients aged 3560 years. The control group c

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Dergachova, D. I., O. I. Klein, A. A. Marinichev, et al. "Hepatoprotective effect of polyphenols in rats with experimental thioacetamide-induced toxic liver pathology." Bulletin of Russian State Medical University, no. 2019;6 (November 27, 2019): 70–76. http://dx.doi.org/10.24075/brsmu.2019.075.

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Non-alcoholic fatty liver disease is associated with a number of disorders (diabetes, obesity, cardiovascular diseases), and can also be induced by drugs or toxic compounds. Recently the important branch of medicine is the search for effective means of prevention and treatment of fatty hepatosis. Our work was aimed to study the effect of some biologically active natural polyphenols (resveratrol and pinosylvin stilbenes as well as dihydromyricetin dihydroflavonol) on the function and histologic features of the liver. In the experimental model of thioacetamide-induced toxic hepaptitis, the male

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Sirchak, Yelyzaveta S., Vasilij I. Griga, Nelli V. Bedey та Ivan I. Pushkash. "CHANGES IN THE LEVEL OF α1-ANTITRYPSIN IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE". Wiadomości Lekarskie 73, № 3 (2020): 508–11. http://dx.doi.org/10.36740/wlek202003119.

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The aim: To investigate changes in the level of α1-antitrypsin (A1AT) in blood and in stool and their diagnostic value in patients with NAFLD and with impaired carbohydrate metabolism at different stages of liver damage. Materials and methods: 34 patients with non-alcoholic fatty hepatosis (NAFH) and 40 patients with non-alcoholic steatohepatitis (NASH) were examined. Enzyme-linked immunosorbent assay for all patients with serum and coli was performed by determining the level of A1AT. Results: In patients with NAFLD, in combination with IR, the level of A1AT in the blood plasma is only 1.6 tim

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Mekhtiev, S. N., O. A. Mekhtieva, and Z. M. Ibragimova. "Functional gall-bladder disorders and non-alcoholic fatty liver disease: clinical features and new approaches to therapy." Meditsinskiy sovet = Medical Council, no. 15 (October 22, 2020): 54–64. http://dx.doi.org/10.21518/2079-701x-2020-15-54-64.

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Introduction. Statistical data indicate a frequent combination of functional biliary disorders with non-alcoholic fatty liver disease.Aim. To study the efficacy and safety of Phosphogliv® URSO in patients with functional disorders of the gall-bladder, biliary sludge in combination with fatty hepatosis in comparison with the group receiving monotherapy ursodeoxycholic acid (UDCA).Materials and methods. The study included 30 patients with a diagnosis of functional gall-bladder disorder, biliary sludge in combination with non-alcoholic fatty liver disease. Patients of the main group received mono

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Pavlovskyi, S. "EFFICIENCY OF COMPLEX PATHOGENIC APPROACH FOR TREATMENT OF PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS COMBINED WITH TYPE 2 DIABETES MELLITUS." Ukrainian Scientific Medical Youth Journal 106, no. 2 (2018): 32–36. http://dx.doi.org/10.32345/usmyj.2(106).2018.32-36.

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Aim is to optimize treatment of non-alcoholic fatty liver disease (NAFLD) combined with type 2 diabetes mellitus. 100 patients with NAFLD in stage of non-alcoholic steatohepatitis (NASH) were enrolled into study. Application of S-adenosylmethionine during the treatment of patients with non-alcoholic fatty liver disease (NAFLD) had high efficacy in the normalization of the functional, biochemical and cytokine profile of the blood. Combination of gliclizide and pioglitazone led to the decrease in the levels of cytolysis and mesenchymal-inflammatory syndromes, stabilization of lipid metabolism. T

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Sirchak, Yelyzaveta S., Vasilij I. Griga, and Oksana I. Petrichko. "CORRECTION OF AUTONOMIC AND COGNITIVE DISTURBANCES IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE." Wiadomości Lekarskie 73, no. 10 (2020): 2198–203. http://dx.doi.org/10.36740/wlek202010117.

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The aim: To explore the features of the congnitive (CD) and neurovegetative dysfunctions (NVD) of patients with different forms of non-alcoholic fatty liver disease NAFLD (nonalcoholic fatty hepatosis (NAFH) and non-alcoholic steatohepatitis (NASH)) and type 2 diabetes mellitus (T2DM), as well as their dynamics against the background of complex therapy using armadin (2-ethyl-6-methyl-3-hydroxypyridine succinate). Materials and methods: 50 patients with NAFLD (24 patients with NAFH and 26 patients with NASH) and T2DM were examined. Dysfunction of central and vegetative nervous system was carrie

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Yefimenko, T. I., and M. R. Mykytyuk. "Non-alcoholic fatty liver disease: time for changes." INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 17, no. 4 (2021): 334–45. http://dx.doi.org/10.22141/2224-0721.17.4.2021.237350.

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The review contains updated information on the epidemiology, etiology, pathogenesis, diagnosis, treatment and prevention of non-alcoholic fatty liver disease (NAFLD). We searched for terms including NAFLD, non-alcoholic steatohepatitis (NASH), metabolic syndrome and type 2 diabetes mellitus in literature published over the past 5 years using the Scopus, Web of Science, CyberLeninka, PubMed databases. The concept of NAFLD includes two morphological forms of the disease with different prognosis: non-alcoholic fatty hepatosis and NASH. The severity of NASH is quite variable, including fibrosis, c

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Druzhinin, Valentin N., Vadim G. Suvorov, Nikolay V. Druzhinin, Aleksandr N. Cherniyi, and Sergey N. Troynyakov. "X-ray computer densitometry in the diagnosis of fat hepatosis." Russian Journal of Occupational Health and Industrial Ecology 60, no. 10 (2020): 681–86. http://dx.doi.org/10.31089/1026-9428-2020-60-10-681-686.

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Currently, the problem of reducing the risk of developing fat liver hepatosis from exposure to household and industrial toxicants among the working-age population continues to be an important medical and social problem, since not timely diagnosis of the disease can lead to its progressive course with the development of inflammatory changes, necrosis and liver fibrosis up to cirrhosis and hepatocellular cancer. In this regard, the search for methods and techniques that optimize the diagnosis of fat hepatosis is relevant. Modern methods of radiation diagnostics of liver density characteristics c

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SOROKINA, TATIANA V., VALENTINA V. DAVYDOVA, NATALIA Yu KOLESNIK, et al. "APPLICATION OF ORGANIC COMPOUNDS IN THERAPEUTIC PRACTICE FOR LIVER FUNCTION DISTURBANCES." Bulletin of Contemporary Clinical Medicine 15, no. 2 (2022): 60–66. http://dx.doi.org/10.20969/vskm.2022.15(2).60-66.

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Introduction. The nonspecificity of the clinical manifestations of the initial stage of non-alcoholic fatty liver disease (NAFLD) - the stage of steatosis, is the reason for the untimely correction and progression of this disease. Aim. The aim of the study was to conduct a randomized open comparative study to determine the effectiveness of the use of the food supplement FanDetox as a source of organic compounds in liver function disorders. Material and methods. This study was a single-center randomized open one and included the study of the possibility of using the herbal product FanDetox in t

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Sulaeman, Agus, A. Rifai Amiruddin, and Gatot Susilo Lawrence. "Metabolic Syndrome (MetS) and Nonalcoholic Steatohepatitis (NASH): Study of biochemical markers Free Fatty Acid (FFA), Total Antioxidant Status (TAOS), Adiponectin, Transforming Growth Factor (TGF-beta1), in occurence of NASH." Indonesian Biomedical Journal 1, no. 1 (2009): 40. http://dx.doi.org/10.18585/inabj.v1i1.81.

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BACKGROUND: The prevalence of metabolic syndrome (MetS) in USA and Makassar are 22% and 23.7%. The prevalence of Non Alcoholic Steatosis Hepatosis (NASH) in MetS has not been reported. Study in Non-alcoholic Fatty Liver Disease (NAFLD) is 25–90 % in obesity patients. In NASH, there is accumulation of lipid in hepatocyte (raised free fatty acid level), raised stress oxidative (decreased total antioxidant status), raised of inflammation process (decreased adiponectin) and hepatic fibrotic process (raised TGF β1). The aim of this study is to investigate the correlation of free fatty acid, total a

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Nayak, Saffalya, Pratima Kumari Sahu, Roma Rattan, Srikrushna Mahapatra, and Debjyoti Mohapatra. "Irisin levels in type 2 diabetes mellitus with and without non-alcoholic fatty liver disease: a case-control study." Prospects in Pharmaceutical Sciences 22, no. 3 (2024): 210–18. http://dx.doi.org/10.56782/pps.254.

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Background: Fatty liver disease, particularly non-alcoholic fatty liver disease (NAFLD), affects around 25% of adults globally and up to 40% in developed countries. Often coexisting with type 2 diabetes mellitus (T2DM), NAFLD is linked to insulin resistance and metabolic syndrome. Irisin, a myokine induced by exercise, shows promise in enhancing insulin sensitivity, reducing hepatic steatosis, and improving metabolic health. Despite its potential, further research is needed to fully understand irisin's mechanisms and clinical implications in NAFLD and T2DM. Objectives: This study investigates

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Kravchenko, V. M., Z. V. Shovkova, I. V. Senyuk, and O. V. Shovkova. "The study of lipotropic action of extract from fruit prunus domestica «Prunofit» byanimal models of alcoholic liver diseases." Farmatsevtychnyi zhurnal, no. 6 (December 9, 2020): 86–91. http://dx.doi.org/10.32352/0367-3057.6.20.09.

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Searchingof drugs that normalize the function of the digestive glands are important because disruption of digestion underlie the pathogenesis of many diseases such as gastroesophageal reflux disease, hepatitis, gastric ulcer, irritable bowel syndrome, cancer etc. The use of herbal objects containing fibres is a promising direction for solving of the mentioned problem. We were attracted by fruits of Prunus domestica which are rich in fibres (homo- and heteropolsaccharides) and are used in folk medicine as a laxative and hepatoprotective agent. The aim of this experimental study was to inv

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Dynnyk, O. B., S. E. Mostovy, G. L. Boyko, E. A. Nastenko, and N. G. Gnoeva. "The Relationship between Atherosclerosis and Non-Alcoholic Fatty Liver Disease According to Polysystemic Ultrasound of the Arteries and Hepatic Steatometry." Ukrainian journal of cardiovascular surgery, no. 3 (40) (September 18, 2020): 88–92. http://dx.doi.org/10.30702/ujcvs/20.4009/046088-092/72.7.

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 Introduction. Coronary heart disease (CHD) remains the most common cause of death and disability in Ukraine and around the world. CHD is caused by atherosclerosis. Non-alcoholic fatty liver disease (NAFLD) is considered an independent predictor of CHD. Aim. To identify the relationship between atherosclerosis and NAFLD according to polysystemic ultrasound (ps-US) of the arteries and liver steatometry. Materials and methods. We conducted an open prospective study in 2019 of 93 people, including 58 women and 35 men aged 22 to 79 years. Chronic CHD was detected in 36 patients a

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Nasibullin, B. A., A. Ya Oleshko, A. B. Zmievskiy, E. I. Baholdina та I. V. Savitskiy. "Сравнительная оценка результативности использования бентонитовых и глауконитовых глин на структурно-функциональные характеристики печени крыс с алкогольным гепатитом = Comparative evaluation of the use of bentonite and glauconitic clay on the structural and functional characteristics of rat liver with alcoholic hepatitis". Journal of Education, Health and Sport 5, № 2 (2015): 165–72. https://doi.org/10.5281/zenodo.15716.

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<strong>Nasibullin B A, Oleshko A Ya, Zmievskiy A B, Baholdina E I, Savitskiy I V. </strong><strong>Сравнительная</strong> <strong>оценка</strong> <strong>результативности</strong> <strong>использования</strong> <strong>бентонитовых</strong> <strong>и</strong> <strong>глауконитовых</strong> <strong>глин</strong> <strong>на</strong> <strong>структурно</strong><strong>-</strong><strong>функциональные</strong> <strong>характеристики</strong> <strong>печени</strong> <strong>крыс</strong> <strong>с</strong> <strong>алкогольным</strong> <strong>гепатитом</strong><strong> = Comparative evaluation of

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Rasskazova, Maria A., Sergey V. Vorobyev, and Helen N. Butova. "Possibilities for the use of ursodeoxycholic acid in the treatment of patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease." Terapevticheskii arkhiv 95, no. 4 (2023): 316–21. http://dx.doi.org/10.26442/00403660.2023.04.202125.

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Aim. To investigate the effect of ursodeoxycholic acid (UDCA) on the degree of steatosis, indicators of carbohydrate, lipid metabolism, body weight in patients with type 2 diabetes mellitus (DM) in combination with non-alcoholic fatty liver disease (NAFLD). Materials and methods. A prospective cohort comparative study included 36 patients with DM and NAFLD. Patients received UDCA at a dose of 15 mg/kg/day for 6 months, and also followed the recommendations for lifestyle changes through diet and exercise. To compare the results obtained during the study, a control group of patients was re

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Didenko, V. I., I. A. Klenina, O. I. Hrabovska, et al. "Liver structure and fibrosis markers in modeling alcohol-induced liver injury and correction of detected disorders." GASTROENTEROLOGY 57, no. 3 (2023): 147–53. http://dx.doi.org/10.22141/2308-2097.57.3.2023.553.

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Background. Chronic alcohol use leads to alcoholic liver fibrosis. Today, a sufficient number of scientific studies are focused on the pathometabolic mechanisms of liver fibrosis development and formation in animal models. The purpose of our study was to investigate structural changes and liver stiffness, biochemical markers of fibrosis in rats with chronic alcoholic liver injury (CALI) modeling and to evaluate the changes of these parameters with different types of treatment. Materials and methods. Eighty-nine rats were divided into experimental groups depending on the duration of alcohol ex

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Tsygankov, D. A., and O. M. Polikutina. "Non-alcoholic fatty liver disease and ultrasound markers of obesity as unfavorable factors in the course of coronary artery disease." Russian Journal of Cardiology 29, no. 5 (2024): 5894. http://dx.doi.org/10.15829/1560-4071-2024-5894.

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Aim. To evaluate the association of non-alcoholic fatty liver disease (NAFLD) with markers of visceral obesity in patients with coronary artery disease (CAD).Material and methods. We examined 125 patients hospitalized in the emergency cardiology department with CAD (female — 41,6%, male — 58,4%) and body mass index of 18,5-35,0 kg/m2. The median age of the subjects was 68 [61,0;74,0] years. We assessed following ultrasound parameters of visceral obesity: intraabdominal fat thickness (IAFT), abdominal wall fat index (WFI), preperitoneal fat thickness (PFT), subcutaneous adipose tissue (SAT), re

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Gubergrits, N. B., N. V. Byelyayeva, G. M. Lukashevich, and K. N. Borodiy. "Cholesterosis: is it related to pancreatology?" Herald of Pancreatic Club 53, no. 4 (2021): 22–28. http://dx.doi.org/10.33149/vkp.2021.04.03.

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Gallbladder (GB) cholesterosis is a disease characterized by impaired cholesterol metabolism with its predominant deposition in the GB wall. GB cholesterosis is considered as a component of lipid distress syndrome, i. e. a combination of a range of pathological conditions caused by lipid metabolism disorders (atherosclerosis, lipogenic pancreatitis, GB cholesterosis, fatty hepatosis). Indeed, GB cholesterosis is often detected in patients with coronary atherosclerosis, hypertension, obesity, and non-alcoholic steatohepatitis. This allows us to consider the GB as a target organ in atherogenic d

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Bilovol, O. M., I. I. Kniazkova, O. V. Zemlianitsyna, et al. "Hepatic fibrosis as an additional risk factor for the development of cardiovascular disorders in patients with type 2 diabetes mellitus with non-alcoholic fatty liver disease." Medicni perspektivi (Medical perspectives) 26, no. 2 (2021): 126–34. http://dx.doi.org/10.26641/2307-0404.2021.2.234639.

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The aim of the study was to determine the relationship between the degree of progression of liver fibrosis and the risk of cardiovascular complications in patients with Type 2 diabetes mellitus (DM) with non-alcoholic fatty liver disease (NAFLD). The study included 110 patients with Type 2 diabetes (62 men and 48 women), the average age of the subjects was 52.07±1.11 years. All patients were divided into 2 groups: the main group included 72 patients with Type 2 diabetes with concomitant NAFLD (38 men and 34 women); the control group included 38 patients with Type 2 diabetes without clinical ma

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Bilovol, O.M., I.I. Kniazkova, O.V. Zemlianitsyna, et al. "Hepatic fibrosis as an additional risk factor for the development of cardiovascular disorders in patients with type 2 diabetes mellitus with non-alcoholic fatty liver disease." Medicni perspektivi 26, no. 2 (2021): 126–34. https://doi.org/10.26641/2307-0404.2021.2.234639.

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The aim of the study was to determine the relationship between the degree of progression of liver fibrosis and the risk of cardiovascular complications in patients with Type 2 diabetes mellitus (DM) with non-alcoholic fatty liver disease (NAFLD). The study included 110 patients with Type 2 diabetes (62 men and 48 women), the average age of the subjects was 52.07±1.11 years. All patients were divided into 2 groups: the main group included 72 patients with Type 2 diabetes with concomitant NAFLD (38 men and 34 women); the control group included 38 patients with Type 2 diabetes without clin

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Pirogova, I. Yu, S. P. Sinitsyn, and V. S. Chulkov. "Clinical efficacy of Heptrong in patients with non-alcoholic liver disease in real clinical practice (pilot study)." Experimental and Clinical Gastroenterology, no. 12 (December 23, 2020): 109–18. http://dx.doi.org/10.31146/1682-8658-ecg-184-12-109-118.

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The purpose of the study: to assess clinical efficacy, dynamics of liver steatosis, effect on insulin resistance and hypolipidemic, ammonia level, systemic inflammation of the Heptrong in patients with non-alcoholic fatty liver disease (NAFLD) and dyslipidemia with obesity.Materials and methods. The study included 40 patients (23 men), age Me 48 (41–53) years, BMI Me 30.5 (28–34) kg / sqm. Inclusion criterion: presence of fatty hepatosis in ultrasound and the ALT level is more than 1.5 norms. Asthenia (AVS) was detected in 78% of patients, abdominal pain in 65% (hepatomegaly, chronic cholecyst

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Samoylova, Yuliya G., Mariya V. Matveeva, Tatyana A. Filippova, et al. "Clinical and Metabolic Profile and Cognitive Functions in Children and Adolescents with Carbohydrate Metabolism Disorders Depending on Body Weight." I.P. Pavlov Russian Medical Biological Herald 33, no. 2 (2025): 221–30. https://doi.org/10.17816/pavlovj611176.

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INTRODUCTION: Hyperglycemia causes glucotoxicity of neurons via different mechanisms, and, in combination with obesity, is a strong predictor of cognitive dysfunction. Free fatty acids and circulating cytokines cross the blood-brain barrier leading to neuroinflammation and proliferation of microglia. These alterations can be detected using neuroimaging methods. Thus, evaluation of cognitive functions and glycemic profile seems relevant in children with disorders of carbohydrate metabolism and different weights. AIM: To analyze clinical and metabolic profile and cognitive functions in children

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Vasyukova, O. V., P. L. Okorokov, and V. A. Peterkova. "One-hour postload plasma glucose levels as a new criterion for assessing insulin secretion in obese children." Diabetes mellitus 23, no. 6 (2021): 523–31. http://dx.doi.org/10.14341/dm12656.

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BACKGROUND: Incidence of Type 2 Diabetes Mellitus (T2DM) and associated dysglycemic conditions, increasing the risk of diabetes development, continues to rise worldwide, most notably due to ever-growing obesity rate. Early identification of the persons who are exposed to the risk of T2DM development holds much significance for prevention of both this disease and associated cardiometabolic complications.AIM: To study characteristics of insulin secretion and insulin sensitivity among obese children and adolescents versus the glycemic level 60 minutes (GL60) after the standard oral glucose tolera

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Denefil, O., and О. Bolyukh. "Interleukins changes in blood of non-ethanol liver damage rats of different sex." Journal of Education, Health and Sport 12, no. 8 (2022): 428–37. http://dx.doi.org/10.12775/jehs.2022.12.08.045.

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Non-alcoholic liver disease is associated with liver injury, such as steatosis, steatohepatitis, fibrosis and cirrhosis. During their development, inflammation is occure and organs damage develops by help of cytokines influences. The intensity of injury depends on sex. The aim of the study was to evaluate changes of interleukins in the blood of male and female rats with hepatosis, hepatitis used by overdrinking of glucose. Material and methods of investigation. The experiments were performed on 60 male and 60 female outbred rats aged from four monthes (start of experiment). Animals were divide

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Mundiri, Nur Azmiati, Meta Maulida Damayanti, Maya Tejasari, Annisa Rahmah Furqaani, and R. A. Retno Ekowati. "Pengaruh Fraksi Air Buah Lemon terhadap Gambaran Morfologi Jaringan Hati Mencit Tua yang Diberi Pakan Tinggi Lemak." Jurnal Integrasi Kesehatan & Sains 1, no. 1 (2019): 49–53. http://dx.doi.org/10.29313/jiks.v1i1.4321.

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Dislipidemia merupakan salah satu faktor risiko dari non alcoholic fatty liver disease (NAFLD). NAFLD mempunyai karakteristik steatosis hepatik, hepatocyte ballooning, inflamasi lobular, dan fibrosis. Kandungan flavonoid pada Citrus limon dipercaya dapat mencegah steatosis hepatik. Tujuan penelitian ini mengetahui pengaruh fraksi air buah lemon terhadap gambaran morfologi jaringan hati mencit tua yang diberi pakan tinggi lemak. Penelitian ini merupakan penelitian eksperimental dengan subjek penelitian adalah mencit (Mus musculus) jantan galur DDY tua yang dibagi menjadi empat kelompok secara a

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Kirchheimer, J. C., K. Huber, P. Polterauer, and B. R. Binder. "Urokinase Antigen in Plasma of Patients with Liver Cirrhosis and Hepatoma." Thrombosis and Haemostasis 54, no. 03 (1985): 617–18. http://dx.doi.org/10.1055/s-0038-1660082.

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SummaryPlasma urokinase antigen levels were studied in 78 patients suffering from liver diseases. Blood was drawn before any specific medication was initiated. Impairment of liver function was comparable in all patients. In both groups of cirrhotic liver disease (alcoholic and non-alcoholic), normal levels of plasma urokinase antigen were found as compared to age-matched control groups. In both groups of patients with hepatomas (with or without a history of liver cirrhosis), however, significantly increased plasma urokinase antigen levels could be determined. These data indicate that an increa

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Imanuel Setiawan, Stefanus, and Juferdy Kurniawan. "Pilihan Tatalaksana Penyakit Perlemakan Hati Non-Alkohol (Non-Alcoholic Fatty Liver Disease/ NAFLD)." Cermin Dunia Kedokteran 48, no. 3 (2021): 173. http://dx.doi.org/10.55175/cdk.v48i3.1336.

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<p>Penyakit perlemakan hati non-alkohol (Non-alcoholic fatty liver disease/ NAFLD) merupakan kondisi adanya steatosis hepatik, inflamasi, dan kerusakan hepatosit (ballooning degeneration). NAFLD tidak hanya dianggap penyakit hati primer, tetapi juga merupakan bagian dari sindrom metabolik atau kondisi resistensi insulin dan penyakit terkait gaya hidup seperti diabetes, dislipidemia, dan hipertensi. Strategi tatalaksana NAFLD dimulai dari modifikasi gaya hidup, dapat dilanjutkan dengan terapi komponen sindrom metabolik, farmakoterapi, hingga penatalaksanaan sirosis.</p><p>Non-

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Pritulo, Olga A., Irina V. Rychkova, and Naje M. Ya Maraqa. "Biological therapy of psoriasis in the era of COVID-19: discussing the risks and benefits." Russian Journal of Skin and Venereal Diseases 24, no. 5 (2022): 485–92. http://dx.doi.org/10.17816/dv96248.

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BACKGROUND: The new coronavirus infection COVID-19 in 2020 has spread widely around the world, including the Russian Federation. Risk factors for adverse outcomes of COVID-19, such as obesity, diabetes, chronic heart and kidney diseases, non-alcoholic fatty liver hepatosis, often accompany psoriasis, especially severe. Assessment and reduction of these risks have become an integral task of psoriasis therapy. An important issue was the use of immunosuppressive therapy in patients during the pandemic. AIMS: In this article, we tried to analyze the international experience of colleagues wit

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Dewi, Ni Made Gita Kusuma, I. Wayan Sugiritama, I. Gusti Ayu Widianti, I. Nyoman Gede Wardana, Desak Ketut Ernawati, and I. Putu Bayu Mayura. "Pengaruh Ekstrak Etanol Kubis Ungu terhadap Kadar Malondialdehida, Superoksida Dismutase dan Derajat Steatosis Hati pada Tikus Model NAFLD." Jurnal Ners 9, no. 2 (2025): 3286–90. https://doi.org/10.31004/jn.v9i2.43013.

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Non-Alcoholic Fatty Liver Disease (NAFLD) adalah gangguan hati kronis yang ditandai dengan akumulasi lemak berlebih dalam hepatosit dan berkaitan dengan sindrom metabolik. Stres oksidatif berperan dalam progresi NAFLD, dengan kadar malondialdehida (MDA) dan aktivitas superoksida dismutase (SOD) sebagai biomarker. Kubis ungu (Brassica oleracea var. capitata L.) memiliki kandungan antosianin tinggi yang bersifat antioksidan, namun efek hepatoprotektifnya terhadap NAFLD masih perlu diteliti lebih lanjut. Penelitian ini bertujuan untuk mengevaluasi efek hepatoprotektif ekstrak etanol kubis ungu te

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Denefil, O.V., and О.O. Bolyukh. "Interleukins changes in blood of non-ethanol liver damage rats of different sex." Journal of Education, Health and Sport 12, no. 8 (2022): 428–37. https://doi.org/10.12775/JEHS.2022.12.08.045.

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<strong>Denefil O</strong><strong>.</strong><strong>V</strong><strong>., </strong><strong>Bolyukh</strong> <strong>О.</strong><strong>O</strong><strong>.</strong> <strong>Interleukins changes in blood of non-ethanol liver damage rats of different sex. J</strong><strong>ournal of Education, Heal</strong><strong>th and Sport. 2022;12(8):42</strong><strong>8</strong><strong>-4</strong><strong>37</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.2022.12.08.045</strong> <strong>https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.08.045</strong> <strong>https://z

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Santoso, Putra, Rita Maliza, Qonitah Fadhilah, and Siti Jamalul Insani. "Beneficial Effect of Pachyrhizus erosus Fiber as a Supplemental Diet to Counteract High Sugar-Induced Fatty Liver Disease in Mice." Romanian Journal of Diabetes Nutrition and Metabolic Diseases 26, no. 4 (2019): 353–60. http://dx.doi.org/10.2478/rjdnmd-2019-0038.

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Abstract Background and aims: Edible fiber isolated from the tuber of yam bean (Pachyrhizus erosus, Leguminosae) has been suggested to prevent the development of metabolic diseases caused by excessively consuming sugary foods. However, it is unclarified whether P. erosus fiber (PEF) is also capable of preventing liver diseases. This study aimed to determine the effectivity of PEF in counteracting the development of non-alcoholic fatty liver disease (NAFLD) caused by excessive intake of high-sugar diet (HSD). Material and method: 25% of PEF in HSD (w/w) was fed in BALB/c mice for eight weeks fo

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Dudina, Marina O., Irina R. Suslova, Mariya S. Khalzova, et al. "Molecular and cellular mechanisms of acute cytotoxic liver damage as potential biological targets for magnesium-containing cell-protective drug." Research Results in Pharmacology 4, no. (3) (2018): 9–15. https://doi.org/10.3897/rrpharmacology.4.29754.

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Introduction. Many anti-tumor drugs have a high potential for toxic damage to liver cells, which makes it necessary to identify molecular mechanisms of the development of the negative impact of drugs on the liver and to develop effective methods for preventing and correcting this adverse effect. Materials and methods. The study was performed on 30 nonlinear white rats of both sexes weighing 180–220 g, divided into 3 equal groups (n = 10 in each): intact control, control with liver pathology and experimental group of rats receiving the test substance LBK-527 at a dose of 100 mg/kg/day intragast

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Sufyan, Dian Luthfiana. "Pengaruh Pemberian Jus Terong Ungu terhadap Perlemakan Hati Tikus Wistar." Jurnal Ilmiah Kesehatan 18, no. 2 (2019): 59–63. http://dx.doi.org/10.33221/jikes.v18i2.301.

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ABSTRACT Non Alcoholic Fatty Liver Disease (NAFLD) is an infiltration of fat inside hepatocytes until exceeding 5% of the liver weight. Eggplant (Solanum melongena L.) contain high anthocyanin level, (8 - 85 mg per 100 gram edible portion) and pectin fiber. This study was aimed to determine the effect of eggplant juice to the fatty liver of Rattus novergicus strain Wistar that were given atherogenic diet. This study using control group post test design performed in wistar rat that placed in pharmacologic laboratory of Brawijaya University. Sampling was carried out by completely random sa

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Jurnalis, Yusri Diane, Yorva Sayoeti, and Elfitrimelly Elfitrimelly. "Peran Antioksidan pada Non Alcoholic Fatty Liver Disease (NAFLD)." Jurnal Kesehatan Andalas 3, no. 1 (2014). http://dx.doi.org/10.25077/jka.v3i1.18.

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AbstrakNonalcoholic Fatty Liver Disease (NAFLD) merupakan penyebab tersering penyakit hati kronik pada anak dan remaja diseluruh dunia. NAFLD berhubungan dengan obesitas, diabetes melitus tipe 2 dan sindrom metabolik. Resistensi insulin memegang peranan penting dalam patogenesis molecular terjadinya NAFLD. Ketidakseimbangan prooksidan dan antioksidan pada sel hepatosis menentukan progresifitas penyakit ini. Sebagai antioksidan telah dilakukan penelitian mengenai efek antioksidan vitamin E, vitamin C, betaine, N-asetil sistein, probucol dan silymarin. Antioksidan tersebut memperlihatkan perbaik

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"Reverse of portal flow during acute alcoholic hepatosis." European Journal of Ultrasound 7 (February 1998): S52. http://dx.doi.org/10.1016/s0929-8266(97)80309-6.

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Denefil, O. V. "The rates of middle molecules in the blood in rats with different motor activity in alcoholic and non alcoholic exerimental hepatosis." December 28, 2021. https://doi.org/10.12775/JEHS.2021.11.12.032.

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Denefil O. V. The rates of middle molecules in the blood in rats with different motor activity in alcoholic and non alcoholic exerimental hepatosis. Journal of Education, Health and Sport. 2021;11(12):385-395. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.12.032   https://apcz.umk.pl/JEHS/article/view/JEHS.2021.11.12.032 https://zenodo.org/record/5834338         The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published wi

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Malyavskaya, Svetlana I., Andrey V. Lebedev, and Galina N. Kostrova. "HORMONAL AND METABOLIC FEATURES OF PUBERTY IN ADOLESCENTS WITH ULTRASOUND SIGNS OF FATTY HEPATOSIS (ON THE EXAMPLE OF ARKHANGELSK)." Ekologiya cheloveka (Human Ecology), December 7, 2022. http://dx.doi.org/10.17816/humeco109055.

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The aim - is to establish the nature of hormonal and metabolic disorders and the relationship of atherogenic risk factors in puberty in adolescents with ultrasound signs of fatty hepatosis. Methods. To assess the nature of disorders and the relationship of the blood lipid spectrum, indicators of peroxidation, chronic inflammation and insulin resistance in adolescents in the puberty period of puberty with ultrasound signs of fatty hepatosis, a single-stage study of a sample of 120 adolescents was conducted. Arkhangelsk at the age of 12-17 years, having instrumental signs of fatty hepatosi

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Лялюкова, Е. А. "Non-alcoholic fatty liver disease: a heterogeneous phenotype. Pleiotropic effects of ursodeoxycholic acid." Лечащий врач, no. 7-8(26) (August 30, 2023). http://dx.doi.org/10.51793/os.2023.26.8.003.

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Введение. Неалкогольная жировая болезнь печени занимает лидирующее место среди причин диффузных заболеваний печени, причем как в России, так и в мире, при этом отмечается устойчивая тенденция к росту заболеваемости, особенно в когорте больных с метаболическими факторами риска. В России за последние 7 лет число больных, страдающих неалкогольной жировой болезнью печени, увеличилось на 10%. При этом распространенность неалкогольной жировой болезни печени, по-видимому, значительно выше, т. к. визуализирующее исследование первой линии – ультрасонография имеет ограниченную чувствительность. Морфолог

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Исайкина, М. А., О. Ю. Исайкина та О. Ю. Трушина. "Метаболически ассоциированная жировая болезнь печени. Чем опасна «безопасная» болезнь? Патогенез сердечно-сосудистых осложнений". Лечащий врач, № 2(28) (21 лютого 2025). https://doi.org/10.51793/os.2025.28.2.002.

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Введение. Неалкогольная жировая болезнь печени чаще всего является скрытым заболеванием с отсутствующими или слабовыраженными клиническими проявлениями. Обычно выявляется как случайная находка при повышении уровня трансаминаз или обнаружении визуализационных признаков жировой дистрофии печени. В определение неалкогольной жировой болезни печени заложены два главных принципа – морфологическая картина микроскопии биоптата, которая полностью соответствует изменениям алкогольного гепатоза, и при этом отсутствие главного этиологический фактора – приема алкоголя в гепатотоксических дозах. Эпидемиолог

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Моргунов, Л. Ю., and Х. С. Мамедгусейнов. "New opportunities for the correction of type 2 diabetes mellitus in patients with liver diseases." Лечащий врач, no. 12(24) (December 30, 2021). http://dx.doi.org/10.51793/os.2021.24.12.004.

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Заболевания печени у пациентов с сахарным диабетом 2 типа встречаются с большей частотой, чем в общей популяции. Сахарный диабет 2-го типа оказывает негативное влияние на состояние печени, нарушая обмен белков, аминокислот, жиров и других веществ в гепатоцитах, что ведет к развитию ее хронических заболеваний. Сочетание патологии печени и сахарного диабета является прогностическим фактором осложнений и летального исхода. Ингибиторы натрий-глюкозного котранспортера 2-го типа (дапаглифлозин, эмпаглифлозин, канаглифлозин) оказывают позитивное влияние на уменьшение степени жирового гепатоза, снижен

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Коstiuk, О. А., and O. V. Denefil. "Mechanisms of ethanol liver damage in rats with different emotionality." January 6, 2021. https://doi.org/10.12775/JEHS.2021.11.1.012.

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Коstiuk О. А., Denefil O. V. Mechanisms of ethanol liver damage in rats with different emotionality. Journal of Education, Health and Sport. 2021;11(1):117-130. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.1.012 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.1.012 https://zenodo.org/record/4464632         The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journ

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