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Journal articles on the topic 'Aldehyde thiosemicarbazone'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

P., Verma, K. Arya K., and Ahmad S. "Oxovanadium(Iv), oxomolybdenum(v) and manganese(II) complexes of Schiff bases derived from thiosemicarbazide." Journal of Indian Chemical Society Vol. 83, Apr 2006 (2006): 327–31. https://doi.org/10.5281/zenodo.5835686.

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Department of Chemistry, Bareilly College, Bareilly-243 00 I, Uttar Pradesh, India <em>Manuscript received 28 October 2003, revised 14 November 2005, accepted 2 December 2005</em> Metal complexes formed by the interaction of bis(furfuryl-2-aldehyde) thiosemicarbazonc [FAL TSC], bis(indole-3-aldehyde) thiosemicarbazone [IALTSC], bis(3-methyl salicylaldehyde) thiosemicarbazone [MSALTSC], bis(S-methyl salicylaldehyde) thiosemicarbazone [M'SALTSC] and bis(S-bromo salicylaldehyde) thiosemicarbazone [BSALTSC] with oxovanadium(Iv), oxo·molybdenum(v) and managanese(n) chloride have been pre

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2

Ozturk, I. I. "SYNTHESIS, CHARACTERIZATION AND HIRSHFELD SURFACE ANALYSIS OF SOME THIOSEMICARBAZONES CONTAINING A FIVE-MEMBERED RING." Журнал структурной химии 64, no. 4 (2023): 109673. http://dx.doi.org/10.26902/jsc_id109673.

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Thiosemicarbazones, which are multidentate ligands, are considered as one of the most important classes of organic compounds due to their broad spectrum of pharmacological effects and their ability to coordinate easily with metal ions. Four thiosemicarbazones, furan-2-carbaldehyde-N-methyl thiosemicarbazone (Hfmtsc), thiophene-2-acetaldehyde thiosemicarbazone (Hattsc), thiophene-2-acetaldehyde-N-methyl thiosemicarbazone (Hatmtsc) and thiophene-2-acetaldehyde-N-ethyl thiosemicarbazone (Hatetsc) were successfully prepared via condensation reaction using substituted aldehyde and (un)substituted t

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3

C., L. JAIN, N. MUNDLEY P. та BAJAJ R. "lron(III), Ruthenium(III), Rhodium(III), PalladiumII), Cobalt(II) and Nickel(II) Complexes with N-(α:-Pyridyl)furfural-2-aldehyde Thiosemicarbazone and N-(α-Pyridyl)thiophene· 2-aldehyde Thiosemicarbazone". Journal of Indian Chemical Society Vol. 69, Nov 1992 (1992): 777–79. https://doi.org/10.5281/zenodo.6044089.

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Department of Chemistry, M. M. H. College, Ghaziabad-201 001<strong> </strong> <em>Manuscript received 10 May </em><em>1991, revised 20 July 1992, accepted 31 July 1992</em> lron(III), Ruthenium(III), Rhodium(III), PalladiumII), Cobalt(II) and Nickel(II) Complexes with N-(α:-Pyridyl)furfural-2-aldehyde Thiosemicarbazone and N-(α-Pyridyl)thiophene· 2-aldehyde Thiosemicarbazone.

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4

Shehzad, Muhammad Tariq, Ajmal Khan, Sobia Ahsan Halim, et al. "Synthesis of indole-substituted thiosemicarbazones as an aldose reductase inhibitor: an in vitro, selectivity and in silico study." Future Medicinal Chemistry 13, no. 14 (2021): 1185–201. http://dx.doi.org/10.4155/fmc-2020-0060.

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Aim: Indole is an important component of many drug molecules, and its conjugation with thiosemicarbazone moiety would be advantageous in finding lead compounds for the development of diabetic complications. Methodology: We have designed, synthesized and evaluated a series of 17 indole-thiosemicarbazones (3a–q) as aldose reductase (ALR2) and aldehyde reductase (ALR1) inhibitors. Results: After in vitro evaluation, all indole-thiosemicarbazones showed significant inhibition against both enzyme ALR1 and ALR2 with IC50 in range of 0.42–20.7 and 1.02–19.1 μM, respectively. The docking study was als

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5

Wakodkar, Rohit R., Mazahar Farooqui, Pravin Kulkarni, and Deepak D. Kayande. "Synthesis and Biological Activity of Some Thiosemicarbazide." Asian Journal of Organic & Medicinal Chemistry 4, no. 4 (2019): 228–31. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p206.

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In this paper, thiosemicarbazone derivatives have been prepared from substituted aromatic aldehyde and thiosemicarbazide in presence of sodium chloride. This method is an efficient, mild, inexpensive, non-toxic and environment benign catalyst. This protocol includes the reaction followed by using sodium chloride to accelerate the reaction in aqueous ethanol. The structure of synthesized compounds were determined by IR, 1H NMR, 13C NMR and mass spectroscopies as well as the compounds were also screened for antibacterial and antifungal activity against certain Gram-negative and Gram-positive bac

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6

Dang, Tran Buu, Le Chi Hien Dat, Vu Tuan Huy, Nguyen Minh Phuong, and Duong Ba Vu. "Salicylic aldehyde-n(4)-(4-ethoxyanilinyl) thiosemicarbazone: optimization of synthesis by surface response and structural characteristics." Tạp chí Khoa học 16, no. 6 (2019): 5. http://dx.doi.org/10.54607/hcmue.js.16.6.2514(2019).

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Salicylic aldehyde-N(4)-(4-ethoxyanilinyl)thiosemicarbazone (H2L) was synthesized by condensation between salicylic aldehyde (SA) and N(4)-(4-ethoxyanilinyl)thiosemicarbazide (TSCZ) in presence of glacial acetic acid as a homogeneous catalyst in ethanol. As a result of analysis by the surface response based on Box – Hunter model with the confidence level of 95%, the expectable yield reached the highest point (around 68%) at 80oC for 10 minutes when approximately 1 mole of SA reacted to equivalently 1 mole of TSCZ. The structure of H2L was solved by IR, UV-Vis, 1H and 13C NMR, HSQC, HMBC and HR

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7

Verma, K. K., N. Nirwan, R. Singh, and N. Bhojak. "Microwave Assisted Synthesis, Characterisation and Biological Activities of Cu(II) Complexes of Few Thiosemicarbazones Ligands." Journal of Scientific Research 15, no. 1 (2023): 275–83. http://dx.doi.org/10.3329/jsr.v15i1.60772.

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Thiosemicarbazones are class of compounds which are obtained by the condensation of thiosemicarbazide with carbonyl compounds. The transition metal complexes of thiosemicarbazones are widely considered due to their broad spectrum of biological activities such as antibacterial, antitumor and antifungal activities. In present research work a series of four novel Cu(II) aryl thiosemicarbazones complexes having the general composition [Cu(L1)2Cl2], [Cu(L2)2Cl2], [Cu(L3)2Cl2] and [Cu(L4)2Cl2]{where L1= 4-nitroacetophenone thiosemicarbazones (4NAT), L2 = 3-nitrobenzaldehyde thiosemicarbazone (3NBT),

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8

Rusnac, Roman, Andrei Ciursin, Sergiu Shova, Angela Sirbu, and Aurelian Gulea. "Synthesis and physical-chemical analysis of the coordination compounds of Cu(II) based on 3-ethoxysalicylaldehyde 4-cyclohexyl-thiosemicarbazone." Studia Universitatis Moldaviae. Seria Științe ale Naturii, no. 1(171) (September 2023): 194–205. http://dx.doi.org/10.59295/sum1(171)2023_26.

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In this article, methods of synthesis and physicochemical analysis of 5 coordination compounds based on Cu(II) ion and 3-ethoxysalicylic aldehyde 4-cyclohexyl-thiosemicarbazone are described. In the first step, the synthesis of the ligand was carried out by means of two classical methods with subsequent refinement, thus obtaining the H2L as a chelator of copper(II) ions. 1H, 13C and 15N-NMR spectroscopy, 13C-DEPT-135 NMR and 15N HSQC-NMR spectroscopy were applied to investigate the structure and geometry of the 3-ethoxysalicylic aldehyde 4-cyclohexyl-thiosemicarbazone. The synthesized substanc

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9

P., UMAPATHY, P. BUDHKAR A., and S. DORAI C. "Synthesis and Spectral Studies on Metal Chelates of Heterocyclic Carboxaldehyde Thiosemicarbazones." Journal of Indian Chemical Society Vol. 63, Aug 1986 (1986): 714–21. https://doi.org/10.5281/zenodo.6295026.

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National Chemical Laboratory, Poona-411 008 <em>Manuscript received 18 September 1984, </em>revised <em>16 August 1985, accepted 12 August 1986</em> Square-planar neutral metal chelates of aldehyde thiosemicarbazones of the type ML,. where M=Ni<sup>II</sup>, Pd<sup>lI</sup> or Pt<sup>II</sup> and HL =thiosemicarbazone or 4-phenyl- or 4-methytthlosemicarbazone of 2-furaldehyde or thiopbene-2-carboxaldehyde or <em>o</em>-nitrobenzaldehyde. have been synthesised and characterised. Jr. uv-visible. <sup>1</sup>H and <sup>13</sup>C nmr and polarographic techniques have been utilised t

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10

G., Valli, Sivakolunthu S., Muthusubramanian S., and Sivasubramanian S. "Synthesis and biological activity of copper(II) mixed ligand complexes with thiophene-2-aldehyde thiosemicarbazone as the primary ligand." Journal of Indian Chemical Society Vol. 77, May 2000 (2000): 252–53. https://doi.org/10.5281/zenodo.5868022.

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School of Chemistry. Madurai Kamaraj University, Madurai-625 021, India Department of Chemistry, S. F. R. College for Women, Sivakasi-626 123, India <em>Manuscript received 25 November 1999. revised 27 January 2000. accepted 11 February 2000</em> The complexing ability of thiophene-2-aldehyde thiosemicarbazone (L) has been investigated. Copper complexes of the type CuLL<sub>1</sub> have been prepared, where L<sub>1</sub> = salicylaldehyde/salicylaldoximelsalicylaldehyde semicarbazone/salicylaldehyde phenylhydrazone/ salicylaldehyde thiosemicarbazone/8-hydroxyquinoline/2-hydroxypyridine. The co

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11

Prathapachandra Kurup, Maliyeckal R., and Marthakutty Joseph. "Transition Metal Complexes of Furan‐2‐aldehyde Thiosemicarbazone." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 33, no. 7 (2003): 1275–87. http://dx.doi.org/10.1081/sim-120023500.

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12

C., L. JAIN, N. MUNDLEY P., KUMAR YOGENDRA та D. SETH P. "Magnetic and Ligand Field Spectral Studies on Iron(m), Ruthenium(m), Rhodium(m), Palladium(ii), Cobalt(ii) and Nickel(ii) Complexes with N-((α-Pyricbri)furfural-2-aldehyde Thiosemicarbazone and N.(α-Pyridyl)thiophene-2- aldehyde Thiosemicarbazone". J. Indian Chem. Soc. Vol. 66, Jul 1989 (1989): 431–34. https://doi.org/10.5281/zenodo.5959038.

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Department of Chemistry, M. M. H. College, Ghaziabad-201 001 Central Indian Pharmaeopceia Laboratory, Raj Nagar, Ghaziabad-201 009 <em>Manuscript received 6 February 1989, accepted 17 May 1989</em> N-(α-Pyridyl)furfural-2-aldehyde thiosemicarbazone (PFT) and N-(α-pyridynthiophene-2-aldehyde thiosemicarbazone (PTT) form complexes of the type [M(PFT/ PTT)CI<sub>2 </sub>]CI(where M(III)=Fe, Ru, Rh), [Pd(PFT1PTT))X<sub>2</sub> (where X =CI, CN) and [M(PFTIPTT)X<sub>2 </sub>](where M(II)= Co, Ni ; X=NH&bdquo;, CI, NO<sub>2</sub>). Magnetic and electronic spectral studies

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13

Botoshanskii, M., P. N. Bourosh, M. D. Revenko, I. D. Korzha, Yu A. Simonov, and T. Panfilie. "Structure of quinoline-8-aldehyde S-methyl thiosemicarbazone dihydrochloride." Journal of Structural Chemistry 50, no. 1 (2009): 181–84. http://dx.doi.org/10.1007/s10947-009-0026-y.

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14

Bourosh, P. N., M. D. Revenko, M. Gdaniec, E. F. Stratulat, and Yu A. Simonov. "Molecular and crystal structure of quinoline-2-aldehyde thiosemicarbazone." Journal of Structural Chemistry 50, no. 3 (2009): 510–13. http://dx.doi.org/10.1007/s10947-009-0078-z.

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15

Bi, Hui-Min, Jun-Ping Hu, Fu-Ying You, Meng-Meng Gao, and Chun-Hua Dong. "QSAR Studies of Biological Activity with Phenylpropyl Aldehyde Thiosemicarbazone Compounds." Asian Journal of Chemistry 26, no. 18 (2014): 5947–50. http://dx.doi.org/10.14233/ajchem.2014.16341.

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16

Kamal, Kishor Verma, and Kumar Verma Suresh. "Microwave Assisted Synthesis, Spectroscopic Characterization and Antimicrobial Activities of Co(II) Complexes Containing Biologically Active Thiosemicarbazone Derivatives." Chemistry Research Journal 6, no. 5 (2021): 80–86. https://doi.org/10.5281/zenodo.11805215.

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<strong>Abstract </strong>In present study two thiosemicarbazone ligands i.e. 4HAT and 3NBT and their  novel Cobal(II) aryl thiosemicarbazones complexes having the general composition [Co(L<sub>1</sub>)<sub>2</sub>Cl<sub>2</sub>], [Co(L<sub>2</sub>)<sub>2</sub>Cl<sub>2</sub>],{where L<sub>1</sub>= 4-Hydroxyacetophenone thiosemicarbazones (4HAT), L<sub>2 </sub>= 3-Nitrobenzaldehyde thiosemicarbazones (3NBT), have been synthesized by the reaction of thiosemicarbazide with substituted aromatic aldehydes and ketones by conventional heating as well as microwave irradiations method followed by

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17

Smolentsev, A. I., L. G. Lavrenova, V. N. Elokhina, A. S. Nakhmanovich, and L. I. Larina. "Crystal structures of pyridine-4-aldehyde thiosemicarbazone perchlorate and trifluoromethane sulfonate." Journal of Structural Chemistry 50, no. 3 (2009): 500–504. http://dx.doi.org/10.1007/s10947-009-0076-1.

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18

Pinheiro, L. S., and M. L. A. Temperini. "SERS effect of pyridine-n-aldehyde thiosemicarbazone on a silver electrode." Journal of Electroanalytical Chemistry and Interfacial Electrochemistry 295, no. 1-2 (1990): 169–81. http://dx.doi.org/10.1016/0022-0728(90)85014-v.

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19

Tianzhu Shi, Tianzhu Shi, Zhengfeng Xie Zhengfeng Xie, Fuyong Wu Fuyong Wu, Yulong Feng Yulong Feng, and Tao Peng and Dezhi Yuan Tao Peng and Dezhi Yuan. "A Type of Conjugated Fuse Heterocyclic Schiff Base Colorimetric andFluorescent Chemosensors for Selective Detection of Picric acid (PA)." Journal of the chemical society of pakistan 46, no. 4 (2024): 377. http://dx.doi.org/10.52568/001506/jcsp/46.04.2024.

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: A series of Schiff base chemosensors (M1, M2 and M3) were designed and synthesized based on conjugated fuse heterocyclic aldehyde thiosemicarbazone. Optical properties of fluorescent probes M1, M2, and M3 toward various nitro explosives 2,4-dinitrotoluene (DNT), o-nitrophenol (ONP), p-nitrophenol (PNP), phenol (PhOH) and nitromethane (NM) were investigated, M1, M2, and M3 could selectively recognize PA with an obvious color change and fluorescence quenching, even in the presence of other coexistence nitro explosives. The detection limit of M1, M2, and M3 were 1.18and#215;10-7 M, 1.13and#215;

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20

Montalvo-Sierra, María Isabel, Miriam A. Martins Alho, Ana María Herrera-Gonzalez, Jesús García-Serrano, and Paola Belem Bocardo-Tovar. "Synthesis of New Hexakis-Heterocyclic Compounds and their Use in the Formation and Stabilization of Au and Ag Nanoparticles." Advanced Materials Research 976 (June 2014): 3–7. http://dx.doi.org/10.4028/www.scientific.net/amr.976.3.

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The stabilization of nanoparticles in solution is a challenge of major proportions, and avoiding the formation of aggregates and eventual coalescence of particles is directly linked to the conservation of its unique properties. In this work, we reported the synthesis of two hexakis-heterocyclic compounds, containing the tetrazole or 2-amino-1,3,4-thiadiazole group, respectively. The hexa-heterocyclic compounds were used in the synthesis and stabilization of Au and Ag nanoparticles. To obtain these molecules was used phosphonitrilic chloride trimer compound as core, which reacted with phenols p

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21

PAUL, PIYALI, and SAMARESH BHATTACHARYA. "Palladium complexes of pyrrole-2-aldehyde thiosemicarbazone: Synthesis, structure and spectral properties." Journal of Chemical Sciences 126, no. 5 (2014): 1547–55. http://dx.doi.org/10.1007/s12039-014-0699-4.

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22

Konshina, Dzhamilya N., Nikita A. Elkov, Igor V. Sukhno, and Valery V. Konshin. "Evaluation of the selectivity of Ag(I) extraction on thiosemicarbazone-silica gels." Сорбционные и хроматографические процессы 23, no. 5 (2023): 822–36. http://dx.doi.org/10.17308/sorpchrom.2023.23/11713.

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The preparation of a series of new functionalised silica gels with fixed thiosemicarbazone fragments by the reaction of aldehyde silica gels with thiosemicarbazide in an ethanol medium in the presence of a catalytic amount of hydrochloric acid is described. The materials were characterized by thermogravimetric analysis and infrared spectroscopy. The choice of unified conditions for concentration and separation is substantiated using the example of silver (I) ions, which allows for comparison of modified materials with different functional capacities. Sorption isotherms of silver (I) ions were

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23

Korkmaz, Gürsel. "A review of recent research on the antimicrobial activities of thiosemicarbazone-based compounds." Journal of New Results in Science 13, no. 1 (2024): 61–83. http://dx.doi.org/10.54187/jnrs.1464723.

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Thiosemicarbazones can be synthesized by condensation of thiosemicarbazides with ketones or aldehydes and play a role as precursors in the synthesis of many compounds such as thiazoles. They can exhibit many biological activities such as anti-inflammatory, antitumor, and antimicrobial properties. The discovery of antibiotics was an important milestone in the treatment of bacterial infections. However, antimicrobial resistance developed by microorganisms has created the need to discover new antimicrobial agents. Thiosemicarbazones and thiosemicarbazone-based compounds show significant antimicro

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24

Omer Ali, Karwan, Nabil Adil Fakhre, and Salim Najm Aldain Saber. "Copper(I) and zinc(II) complexes containing 4-methoxybenz- aldehyde thiosemi- carbazone and triphenylphosphine ligands, synthesis, characterization, and theoretical studies." Bulletin of the Chemical Society of Ethiopia 39, no. 7 (2025): 1301–16. https://doi.org/10.4314/bcse.v39i7.6.

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A new thioamide ligand, 4-methoxybenzaldehyde thiosemicarbazone (L), containing sulfur, nitrogen, and oxygen atoms, was synthesized via condensation of 4-methoxybenzaldehyde with thiosemicarbazide. New tetrahedral copper(I) and zinc(II) complexes of the prepared ligand and triphenylphosphine (Ph3P) as a co-ligand have been synthesized. The ligand and its complexes were characterized by magnetic susceptibility, elemental analysis, molar conductivity, FT-IR, UV-Vis, and 1H, 13C, 31P-NMR techniques. The FT-IR spectra indicated that the (L) ligand coordinates with the metal ions through sulfur and

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25

Karakurt, Tuncay, Hakan Tahtaci, Nuriye Tuna Subasi, Mustafa Er, and Erbil Ağar. "Novel aldehyde and thiosemicarbazone derivatives: Synthesis, spectroscopic characterization, structural studies and molecular docking studies." Journal of Molecular Structure 1125 (December 2016): 470–80. http://dx.doi.org/10.1016/j.molstruc.2016.07.013.

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26

Su, Hongyan, Weiwei Huang, Zhongyue Yang, Hai Lin, and Huakuan Lin. "2-Hydroxy-naphth-1-aldehyde phenyl-thiosemicarbazone: effective thiourea-based sensor for acetate anion." Journal of Inclusion Phenomena and Macrocyclic Chemistry 72, no. 1-2 (2011): 221–25. http://dx.doi.org/10.1007/s10847-011-9969-7.

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27

Rajendran, G., C. S. Amritha, Ruby Anto, and Vino Cheriyan. "Synthesis, thermal and antitumour studies of Th(IV) complexes with furan-2-aldehyde-N-phenyl thiosemicarbazone." Journal of the Serbian Chemical Society 75, no. 6 (2010): 749–61. http://dx.doi.org/10.2298/jsc090729048r.

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Thorium(IV) complexes with the Schiff base furan-2-aldehyde-N-phenyl thiosemicarbazone (L) were synthesised and characterized. The composition and structure of the metal complexes were proposed base on elemental analysis, molar conductivity measurements, FTIR and 1H-NMR spectroscopy. The Schiff base behaves as a neutral bidentate ligand coordinating through the azomethine N and the thioketo S atoms. From various studies, complexes were ascertained the general formula [ThL2X4] and [ThL2Y2] where X represents the monovalent anions NO3-, NCS-, CH3COO-, CH3CHOHCOO-, ClO4-,and Y the bivalent anions

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28

Xu, Yan, zhen Wang, Yun Ling, et al. "Synthesis of Substituted Phenylpropyl Aldehyde Thiosemicarbazone Compounds and Their Bioactivity on Tyrosinase of Cotton Bollworm." Chinese Journal of Organic Chemistry 32, no. 07 (2012): 1278. http://dx.doi.org/10.6023/cjoc1111181.

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29

N., C. DESAI, R. PAREKH B., and A. THAKER K. "Preparation of some Important Medicinal Compounds. Thiosemicarbazones, Thiadiazolines, 4-Thiazolidinones and 5-Aryheiline Derivatives as Antibacterial and Tuberculostatic Agents." Journal of Indian Chemical Society Vol. 64, Aug 1987 (1987): 491–93. https://doi.org/10.5281/zenodo.6200491.

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University Department of Chemistry, Bhavnagar University, Bhavnagar-364 002 <em>Manuscript received 6 August 1984, accepted 20 July 1985</em> Thiosemicarbazides (1) have been prepared by the reaction of initial amine, ammonia and carbon disulphide with ethanol (95%) and sodium chloroacetate, followed by addition of hydrazine hydrate. Benzaldehyde 4-(2-ethoxyphenyl)-3-thiosemicarbazones (2) have been prepared by the condensation of thiosemicarbazide (1) and different aldehydes in boiling ethanol (95%) Thiosemicarbazones (2) treated with NaOH (5%) and potassium ferricyanide solution produced thi

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30

Vaishnav, Brijesh Kumar, and S. K. Verma. "Development of Nickel(II) Thiosemicarbazone Complexes as Potential Antibacterial Agents: Microwave Assisted Synthesis, Spectral Characterization and Antibacterial Studies." Oriental Journal Of Chemistry 41, no. 1 (2025): 193–200. https://doi.org/10.13005/ojc/410123.

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Some novel Nickel(II) aryl thiosemicarbazone complexes with the formula [Ni(LIGAND-1)2(NO3)2], [Ni(LIGAND-2)2(NO3)2], [Ni(LIGAND-3)2(NO3)2], and [Ni(LIGAND-4) 2(NO3)2] have been successfully synthesized. LIGAND-1 corresponds to 4-Phenyl-3-buten-2-one thiosemicarbazone (PBTSC), LIGAND-2 is 4-Hydroxy-3-methylbenzaldehyde thiosemicarbazone (HMBTSC), LIGAND-3 refers to 4-Methoxybenzaldehyde thiosemicarbazone (MBTSC), and LIGAND-4 represents Propiophenone thiosemicarbazone (PTSC). The Ligands were synthesized by reacting thiosemicarbazide with substituted aromatic aldehydes and ketones using microw

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31

Saroha, Mohit, and Jitender M. Khurana. "Acetic acid mediated regioselective synthesis of 2,4,5-trisubstituted thiazoles by a domino multicomponent reaction." New Journal of Chemistry 43, no. 22 (2019): 8644–50. http://dx.doi.org/10.1039/c9nj01717h.

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Acetic acid mediated regioselective synthesis of novel 2,4,5-trisubstituted thiazole derivatives has been reported by a domino reaction of thiosemicarbazide and aldehydes/ketones/isatin, to generate thiosemicarbazones (in situ) followed by addition of arylglyoxal and active methylene/activated C–H acids/pyrazole/indole in ethanol at 80 °C.

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32

Muthukumar, Manisekar, and Periasamy Viswanathamurthi. "Synthesis, spectral characterization and catalytic studies of new ruthenium(II) chalcone thiosemicarbazone complexes." Open Chemistry 8, no. 1 (2010): 229–40. http://dx.doi.org/10.2478/s11532-009-0116-x.

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AbstractA series of new hexa-coordinated ruthenium(II) complexes of the type [Ru(CO)(EPh3)(B)(L)] (E = P or As; B = PPh3, AsPh3 or Py; L = chalcone thiosemicarbazone) have been prepared by reacting [RuHCl(CO)(EPh3)2(B)] (E = P or As; B = PPh3, AsPh3 or Py) with chalcone thiosemicarbazones in benzene under reflux. The new complexes have been characterized by analytical and spectroscopic (IR, UV-vis, 1H, 31P and 13C NMR) methods. On the basis of data obtained, an octahedral structure was assigned for all of the complexes. The chalcone thiosemicarbazones behave as dianionic tridentate O, N, S don

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33

Sunitha, K., Smitha Nair, and P. Palanisamy. "Synthesis, Characterization and Biological Evaluation of Some Novel Azo-Imine Compounds." Asian Journal of Chemistry 34, no. 3 (2022): 663–67. http://dx.doi.org/10.14233/ajchem.2022.23591.

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The oxidative cyclization of thiosemicarbazone (III) synthesized from reaction between substituted aryl aldehydes (I) with thiosemicarbazide (II) was done using ferric chloride as oxidative agent to get 2-amino-5-phenyl-1,3,4-thiadiazole (IV). 2-Amino-5-phenyl-1,3,4-thiadiazole was introduced in condensation reactions with substituted aldehydes to obtain benzylidene imine derivatives (VI)1-5. Further these were treated with sulphanilic acid to give new 2-{[5-phenyl-1,3,4-thiadiazole-2-imino] substituted benzene}diazenyl benzene sulfonic acid derivatives (VII)1-5. These derivatives were further

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Sengupta, Parbati, Rupam Dinda, Saktiprosad Ghosh, and William S. Sheldrick. "Synthesis and characterization of some biologically active ruthenium(II) complexes of thiosemicarbazones of pyridine 2-aldehyde and thiophene 2-aldehyde involving some ring substituted 4-phenylthiosemicarbazides and 4-cyclohexylthiosemicarbazide. Crystal structure of cis-[Ru(PPh3)2(L6H)2](ClO4)2·2H2O [L6H=4-(cyclohexyl) thiosemicarbazone of pyridine 2-aldehyde]." Polyhedron 22, no. 3 (2003): 447–53. http://dx.doi.org/10.1016/s0277-5387(02)01363-3.

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Toan, Vu Ngoc, Nguyen Minh Tri та Nguyen Dinh Thanh. "Substituted 4-Formyl-2H-chromen-2-ones: Their Reaction with N-(2,3,4,6-Tetra-Oacetyl- β-D-galactopyranosyl)thiosemicarbazide, Antibacterial and Antifungal Activity of Their Thiosemicarbazone Products". Current Organic Chemistry 24, № 19 (2020): 2272–82. http://dx.doi.org/10.2174/1385272824999200812132256.

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Several 6- and 7-alkoxy-2-oxo-2H-chromene-4-carbaldehydes were prepared from corresponding alkyl ethers of 6- and 7-hydroxy-4-methyl-2-oxo-2H-chromen-2-ones by oxidation using selenium dioxide. 6- and 7-Alkoxy-4-methyl-2H-chromenes were obtained with yields of 57-85%. Corresponding 4-carbaldehyde derivatives were prepared with yields of 41-67%. Thiosemicarbazones of these aldehydes with D-galactose moiety were synthesized by reaction of these aldehydes with N-(2,3,4,6-tetra-O-acetyl-β-Dgalactopyranosyl) thiosemicarbazide with yields of 62-74%. These thiosemicarbazones were screened for their a

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Harek, Yahia, Lahc�ne Larabi, Leila Boukli, Fatima Kadri, Noureddine Benali-Cherif, and Mohsen M. Mostafa. "Synthesis, characterization, crystal structure and electrochemical behavior of a nickel(II) complex of 5,6-dihydro-2H-pyran-3-aldehyde thiosemicarbazone." Transition Metal Chemistry 30, no. 2 (2005): 121–27. http://dx.doi.org/10.1007/s11243-004-1565-x.

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Alomar, Kusaï, Mustayeen A. Khan, Magali Allain, and Gilles Bouet. "Synthesis, crystal structure and characterization of 3-thiophene aldehyde thiosemicarbazone and its complexes with cobalt(II), nickel(II) and copper(II)." Polyhedron 28, no. 7 (2009): 1273–80. http://dx.doi.org/10.1016/j.poly.2009.02.042.

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Shakya, Bhushan, and Paras Nath Yadav. "Thiosemicarbazones as Potent Anticancer Agents and their Modes of Action." Mini-Reviews in Medicinal Chemistry 20, no. 8 (2020): 638–61. http://dx.doi.org/10.2174/1389557519666191029130310.

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: Thiosemicarbazones (TSCs) are a class of Schiff bases usually obtained by the condensation of thiosemicarbazide with a suitable aldehyde or ketone. TSCs have been the focus of chemists and biologists due to their wide range of pharmacological effects. One of the promising areas in which these excellent metal chelators are being developed is their use against cancer. TSCs have a wide clinical antitumor spectrum with efficacy in various tumor types such as leukemia, pancreatic cancer, breast cancer, non-small cell lung cancer, cervical cancer, prostate cancer and bladder cancer. To obtain bett

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Badannavar, Dr. N. Y. "Exploring the Coordination Chemistry and Biological Applications of Compartmental Complexes of Thiosemicarbazones: Synthesis, Characterization, and Functional Insights." International Journal of Advance and Applied Research 5, no. 44 (2024): 48–57. https://doi.org/10.5281/zenodo.14685664.

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<strong>Abstract:</strong> Compartmental complexes of thiosemicarbazones, a class of versatile ligands derived from thiosemicarbazide and aldehydes or ketones, have garnered significant attention in coordination chemistry due to their ability to form stable chelates with a wide range of metal ions, and their structural flexibility, arising from the presence of both sulfur and nitrogen donor atoms, enables them to adopt diverse coordination modes that facilitate the formation of mono-, bi-, and polynuclear complexes with well-defined geometries, which are not only of theoretical interest but al

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40

Er, Mustafa, Ayşe Şahin, and Hakan Tahtacı. "Synthesis and Characterization of Novel 1,3-Thiazole and 2-Amino-1,3,4-Thiadiazole Derivatives." Macedonian Journal of Chemistry and Chemical Engineering 33, no. 2 (2014): 189. http://dx.doi.org/10.20450/mjcce.2014.522.

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<p>Thiosemicarbazone derivatives <strong>3a–e</strong> were synthesized by the reaction of various aldehydes<strong> 1a–e</strong> with 4-methyl thiosemicarbazide <strong>2</strong> in 78% to 90% yield. Then, the thiazole moieties of the target materials <strong>5a–e</strong> were obtained in high yields (71–93%) using the Hantzsch reaction utilizing thiosemicarbazone derivatives <strong>3a–e</strong> with ethyl-2-chloroacetoacetic ester. The substituted nitrile derivatives <strong>7a–e</strong> were obtained in mode

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M.G., Dhonde, та P. Deshmukh S. "Synthesis and antimicrobial activity of tetra-O-benzoyi-β-D-glucopyranosyl arylidene thiosemicarbazones". Journal of Indian Chemical Society Vol. 88, Feb 2011 (2011): 289–91. https://doi.org/10.5281/zenodo.5773536.

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Shri Mathuradas Mohota College of Science, Nagpur-440 009, Maharashtra, India <em>E-mail </em>: madhudash200l@yahoo.co.in P.G. Department of Chemistry, Shri Shivaji College, Akola-440 001, Maharashtra, India <em>Manuscript received 17 February 2009, revised 30 June 2010, accepted 07 July 2010</em> 4-Tetra-<em>O</em>-benzoyl-β-n-glucopyranosyl-1-arylidine thiosemicarbazones have been synthesised by the interaction or tetra-O-benzoyl-β-D-glucopyranosyl thiosemicarbazlde and aryl aldehydes. These compounds were screened for their antibacterial and antifungal activity against E. coli, S.

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Aljahdali, Mutlaq Shedeed, Yahia Hassan Elmalik, and Gaber Mohamed Abu El-Reash. "Synthesis of some transition metal complexes of novel 1-methylpyrazole-3-aldehyde-4-(2-pyridyl) thiosemicarbazone: Spectroscopic and in vitro biological activity studies." European Journal of Chemistry 5, no. 2 (2014): 201–8. http://dx.doi.org/10.5155/eurjchem.5.2.201-208.952.

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Alomar, Kusaï, Anne Landreau, Marie Kempf, Mustayeen A. Khan, Magali Allain, and Gilles Bouet. "Synthesis, crystal structure, characterization of zinc(II), cadmium(II) complexes with 3-thiophene aldehyde thiosemicarbazone (3TTSCH). Biological activities of 3TTSCH and its complexes." Journal of Inorganic Biochemistry 104, no. 4 (2010): 397–404. http://dx.doi.org/10.1016/j.jinorgbio.2009.11.012.

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Kaplancıklı, Zafer Asım, Mehlika Dilek Altıntop, Belgin Sever, Zerrin Cantürk, and Ahmet Özdemir. "Synthesis andIn VitroEvaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents." Journal of Chemistry 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/1692540.

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In an effort to develop potent antimicrobial agents, new thiosemicarbazone derivatives were synthesizedviathe reaction of 4-[4-(trifluoromethyl)phenyl]thiosemicarbazide with aromatic aldehydes. The compounds were evaluated for their inhibitory effects on pathogenic bacteria and yeasts using the CLSI broth microdilution method. Microplate Alamar Blue Assay was also carried out to determine the antimycobacterial activities of the compounds againstMycobacterium tuberculosisH37Rv. Among these derivatives, compounds5and11were more effective againstEnterococcus faecalis(ATCC 29212) than chlorampheni

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Al-Abboodi1, Doaa Hashim, and Naeemah Al-lami. "NEW METHDOLOGY OF SYNTHESIS PYRAZOLO- THIAZOLO DERIVATIVES WITH STUDY ANTIMICROBAL ACTIVITIES." iraqi journal of market research and consumer protection 16, no. 1 (2024): 1–12. http://dx.doi.org/10.28936/jmracpc16.1.2024.(1).

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In this contribution, new derivatives of thiosemicarbazon, cyclic thiazolidinone, yilidine thiazolidinone, and parazolo-thiazole were synthesized, starting from the reaction of 2 -aminobenzothiazole with p-bromo phenacyl bromide to give the first step of 2(4-bromo phenyl) imidazole (2,1 -b) benzo thiazole (1). Compound (1) then was subjected under Viels Myer Haack to yield 3-carbaldehyde linking with imidazo-benzothiazol (2). Compound (2) condensed with thiosemicarbazide togivenewsynthesis of thiosemicarbazon derivative (3). Compound 4-Oxo-1,3-thiazolidine (4) was constituted from reacting com

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Mahmoudi, Ghodrat, Maria G. Babashkina, Waldemar Maniukiewicz, et al. "Solvent-Induced Formation of Novel Ni(II) Complexes Derived from Bis-Thiosemicarbazone Ligand: An Insight from Experimental and Theoretical Investigations." International Journal of Molecular Sciences 22, no. 10 (2021): 5337. http://dx.doi.org/10.3390/ijms22105337.

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In this work, we report solvent-induced complexation properties of a new N2S2 tetradentate bis-thiosemicarbazone ligand (H2LI), prepared by the condensation of 4-phenylthiosemicarbazide with bis-aldehyde, namely 2,2’-(ethane-1,2-diylbis(oxy)dibenzaldehyde, towards nickel(II). Using ethanol as a reaction medium allowed the isolation of a discrete mononuclear homoleptic complex [NiLI] (1), for which its crystal structure contains three independent molecules, namely 1-I, 1-II, and 1-III, in the asymmetric unit. The doubly deprotonated ligand LI in the structure of 1 is coordinated in a cis-manner

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Lovejoy, David B., and Des R. Richardson. "Novel “hybrid” iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells." Blood 100, no. 2 (2002): 666–76. http://dx.doi.org/10.1182/blood.v100.2.666.

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Abstract We previously demonstrated that 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone (311) and other aroylhydrazone chelators possess potent antineoplastic activity because of their ability to bind iron (Fe). From these studies, we identified structural components of the hydrazones that provide antineoplastic activity, namely the salicylaldehyde and 2-hydroxy-1-naphthylaldehyde moieties. A related group of chelators known as the thiosemicarbazones also show pronounced antitumor activity because of their ability to inhibit ribonucleotide reductase. Considering this, we designed a new s

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Agarwal, Ram K., Lakshman Singh, and Deepak Kumar Sharma. "Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes." Bioinorganic Chemistry and Applications 2006 (2006): 1–10. http://dx.doi.org/10.1155/bca/2006/59509.

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We have synthesized a novel series of Schiff bases by condensation of 4-aminoantipyrine and various aromatic aldehydes followed by reaction with thiosemicarbazide. These thiosemicarbazones are potential ligands toward transition metal ions. The reaction of copper(II) salts with 4[N-(benzalidene)amino]antipyrinethiosemicarbazone (BAAPTS), 4[N-(4′-methoxybenzalidene) amino] antipyrinethiosemicarbozone (MBAAPTS), 4[N-(4′-dimethylamino benzalidene) amino] antipyrinethiosemicarbazone (DABAAPTS), and 4[N-(cinnamalidene) amino] antipyrinethiosemicarbazone (CAAPTS) resulted in the formation of solid c

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Braga, Saulo Feheiberg Pinto, Nayara Cristina Fonseca, Jonas Pereira Ramos, Elaine Maria de Souza-Fagundes, and Renata Barbosa de Oliveira. "Synthesis and cytotoxicity evaluation of thiosemicarbazones and their thiazole derivatives." Brazilian Journal of Pharmaceutical Sciences 52, no. 2 (2016): 299–308. http://dx.doi.org/10.1590/s1984-82502016000200008.

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ABSTRACT The aims of this study were to synthesize a series of thiosemicarbazones and their thiazole derivatives, to investigate their cytotoxic activity against three human cancers and normal (Vero cells) cell lines, and to evaluate the pro-apoptotic potential of the most active compounds. Materials and Methods: The thiosemicarbazones were obtained by reacting an aromatic aldehyde with thiosemicarbazide (yield 71-96%), which were subjected to a cyclization with α-bromoacetophenone to yield the required thiazole heterocycles (yield 63-100%). All the synthesized compounds were screened at 50 µM

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Sever, Belgin, Hasan Soybir, Şennur Görgülü, Zerrin Cantürk, and Mehlika Dilek Altıntop. "Pyrazole Incorporated New Thiosemicarbazones: Design, Synthesis and Investigation of DPP-4 Inhibitory Effects." Molecules 25, no. 21 (2020): 5003. http://dx.doi.org/10.3390/molecules25215003.

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Dipeptidyl peptidase-4 (DPP-4) inhibition has been recognized as a promising approach to develop safe and potent antidiabetic agents for the management of type 2 diabetes. In this context, new thiosemicarbazones (2a–o) were prepared efficiently by the reaction of aromatic aldehydes with 4-[4-(1H-pyrazol-1-yl)phenyl]thiosemicarbazide (1), which was obtained via the reaction of 4-(1H-pyrazol-1-yl)phenyl isothiocyanate with hydrazine hydrate. Compounds 2a–o were evaluated for their DPP-4 inhibitory effects based on a convenient fluorescence-based assay. 4-[4-(1H-pyrazol-1-yl)phenyl]-1-(4-bromoben

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