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Journal articles on the topic 'Aldehydic moiety'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Salus, Kinga, Marcin Hoffmann, Tomasz Siodła, Bożena Wyrzykiewicz, and Donata Pluskota-Karwatka. "Synthesis, structural studies and stability of model cysteine containing DNA–protein cross-links." New Journal of Chemistry 41, no. 6 (2017): 2409–24. http://dx.doi.org/10.1039/c7nj00270j.

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In the presence of N<sup>α</sup>-acetyllysine, cross-links of aldehydic adenine nucleoside adducts with N-acetylcysteine lose an N-acetylcysteine moiety undergoing transformation into amino derivatives.

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2

M., T. EL-HATY, A. ADAM F., E. MOHAMED A., and A. GABR A. "Electronic Spectra of some Heterocyclic Schiff Bases derived from 3-Amino-1 ,2,4-triazole." Journal of Indian Chemical Society Vol. 67, Sep 1990 (1990): 743–47. https://doi.org/10.5281/zenodo.6244210.

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Chemistry Department, Faculty of Science, A swan, Egypt <em>Manuscript received 21 November 1989, revised 14 March 1990, accepted 3 July 1990</em> Electronic spectra of some heterocyclic Schiff bases derived from 3-amino1,2,4-triazole in pure and mixed organic solvents of various polarities have been studied. Band assignments and spectra-structure correlations have been made. The possibility of the hydroxy derivatives to form hydrogen bonded molecular complexes with ethanol has been examined The p<em>K</em>a values of triazole ring and the different substituents attached to the aldehydic moiet

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3

Roy, Chandra D., and Herbert C. Brown. "Monobromoborane - Dimethyl Sulfide—a Highly Promising Reagent for the Regio- and Chemoselective Brominative Cleavage of Terminal Epoxides into Vicinal Bromohydrins." Australian Journal of Chemistry 60, no. 2 (2007): 139. http://dx.doi.org/10.1071/ch06408.

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Monobromoborane–dimethyl sulfide (BH2Br–SMe2) is a highly regio- and chemoselective reagent useful for the brominative cleavage of the epoxy moiety into bromohydrins in the presence of alkenes, alkynes, ethers, acetals, ketals, and acetonides at 0°C, besides being an excellent hydroborating reagent. Several reactive functional groups, such as chloride, ketones, esters, nitriles, nitros, and thioethers, have been accommodated during such transformations. Although the reduction of acetophenone was completely suppressed at –25°C, 4-chlorobenzaldehyde still underwent 12–13% reduction of an aldehyd

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4

Awad, Mohamed K., Mahmoud F. Abdel-Aal, Faten M. Atlam та Hend A. Hekal. "Synthesis of New α-Amino Phosphonates Containing 3-Amino-4(3H) Quinazolinone Moiety as Anticancer and Antimicrobial Agents: DFT, NBO, and Vibrational Studies". Current Organic Synthesis 15, № 2 (2018): 286–96. http://dx.doi.org/10.2174/1570179414666170703141629.

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Aim and Objective: Synthesis of new .-aminophosphonates containing quinazoline moiety through Kabachnik-Fields reaction in the presence of copper triflate catalyst [32], followed by studying their antimicrobial activities and in vitro anticancer activities against liver carcinoma cell line (HepG2) with the hope that new anticancer agents could be developed. Also, the quantum chemical calculations are performed using density functional theory (DFT) to study the effect of the changes of molecular and electronic structures on the biological activity of the investigated compounds. Materials and Me

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5

Bercich, Mark D., Richard C. Cambie, and Peter S. Rutledge. "Experiments Directed Towards the Synthesis of Anthracyclinones. XXXII. Synthesis of Anthraquinone Aldehydes." Australian Journal of Chemistry 52, no. 4 (1999): 241. http://dx.doi.org/10.1071/c98102.

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Syntheses of C2 anthraquinone aldehydes from the commercially availableanthraru¯n (1) have been investigated. A synthesis of the keto aldehyde(2) in nine steps and 73% overall yield was achieved. Syntheses of (2)exploiting selective oxidations of either a C-boundallyl group by Wacker oxidation to introduce the methyl keto functionality orof a C-bound prop-1-enyl moiety by dihydroxylation andoxidative cleavage to generate the C2 formyl group were also developed. Thealdehyde (27) was synthesized in seven steps and in 81% overall yieldfrom (1), and syntheses of the phenolic aldehydes (33), (34),

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6

Tietze, Lutz F., Christian Ott, and Frank Haunert. "Efficient and regioselective synthesis of bridged ring systems by domino Knoevenagel hetero-DielsAlder reaction." Canadian Journal of Chemistry 79, no. 11 (2001): 1511–14. http://dx.doi.org/10.1139/v00-204.

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The bridged heterocycles 1012 were efficiently prepared by a domino Knoevenagel hetero-DielsAlder reaction of N,N'-dimethylbarbituric acid 2 and the aldehydes 68 which contain an allyl moiety as dienophile. In contrast, reaction of 2 and aldehyde 5 with a dimethylallyl moiety leads to the annulated product 9. For the formation of 1012, an exo-Z-syn and for that of 9 an endo-E-syn transition structure is proposed.Key words: bridged compounds, domino reaction, DielsAlder reaction, heterocycles, Knoevenagel reaction.

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7

Zhang, Yue Cheng, Jing Yuan Gao, Nai Yue Shi, and Ji Quan Zhao. "Synthesis of Chiral Tridentate Ligands Embodying the Bispidine Framework and their Application in the Enantioselective Addition of Diethylzinc to Aldehydes." Advanced Materials Research 396-398 (November 2011): 1236–43. http://dx.doi.org/10.4028/www.scientific.net/amr.396-398.1236.

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Several new chiral tridentate ligands with the bispidine moiety were synthesized from N-alkyl bispidines and chiral amino (or hydroxyl) acids. The synthesized ligands were used as catalysts in the enantioselective addition of diethylzinc to several aromatic aldehydes and an aliphatic aldehyde. High yield and enantioselectivity were received in the cases of aromatic aldehydes as substrates especially when the employed chiral ligand has a hydroxyl group attached to the chiral center. The effect of the structure, the amount of tridentate chiral ligands, solvent and temperature on the enantioselec

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8

Colombo, Sara, Julie Oble, Giovanni Poli, et al. "Doubly Metathetic NiCl2-Catalyzed Coupling Between Bis(2-oxazolines) and Aldehydes: A Novel Access to Bis(ester-imine) Derivatives." Molecules 29, no. 23 (2024): 5756. https://doi.org/10.3390/molecules29235756.

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The coupling between bis(2-oxazolines) and two equivalents of aromatic aldehydes in the presence of catalytic amounts of NiCl2 affords an ester-imine product in synthetically useful yields. This virtually unknown, 100% atom-economic transformation involves the formal metathesis between the C=N double bond of the bis(2-oxazoline) moiety, which undergoes ring-opening, and the C=O double bond of the aldehyde. The scope of this transformation is studied, and a mechanism is proposed based on DFT calculations.

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9

Montenegro, Javier, José Reina, and Alicia Rioboo. "Glycosyl Aldehydes: New Scaffolds for the Synthesis of Neoglycoconjugates via Bioorthogonal Oxime Bond Formation." Synthesis 50, no. 04 (2018): 831–45. http://dx.doi.org/10.1055/s-0036-1591082.

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The straightforward preparation of glycosyl neoconjugates by oxime (or hydrazone) bond formation represents a key bioorthogonal tool in chemical biology. However, when this strategy is employed by reacting the reducing end of the glycan moiety, the configuration and the stereochemical information is lost due to partial (or complete) opening of the glycan cyclic hemiacetal and the formation of the corresponding opened tautomers. We have completed the synthesis of a library of glycosyl aldehydes to be used as scaffold for the synthesis of neoglycoconjugates via oxime bond formation. These glycos

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10

Petrikaitė, Vilma, Eduardas Tarasevičius, and Alvydas Pavilonis. "Synthesis and Antimicrobial Properties of Naphthylamine Derivatives Having a Thiazolidinone Moiety." Medicina 47, no. 6 (2011): 47. http://dx.doi.org/10.3390/medicina47060047.

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Objective. The aim of this study was to evaluate the influence of pharmacophores having naphthylamine and nitro groups on the antimicrobial (antibacterial and antifungal) activity of thiazolidinone derivatives. Materials and Methods. The initial 5-substituted-2-methylmercaptothiazolidin-4-ones were subjected to S-demethylation to yield 2-amino-substituted thiazolidinones. 4-Nitro-1-naphthylamine, nitrofuran aldehydes, and nitrobenzene aldehydes were used as pharmacophoric compounds having amino or aldehyde groups. Antimicrobial (antibacterial and antifungal) activity of the new compounds was t

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11

Zaharani, Lia, and Nader Ghaffari Khaligh. "Recent Developments in Catalytic Reductive Etherifications." Malaysian Catalysis-An International Journal 2, no. 1 (2022): 21–31. http://dx.doi.org/10.22452/mcij.vol2no1.2.

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Ether derivatives are versatile organic compounds and have been applied in various fields of academia and the chemical industry. Therefore, it is highly desirable to create procedures for their manufacture that are more efficient and sustainable. Catalytic reductive etherification with carbonyl moiety such as ketones/ aldehydes and carboxylic acid derivatives has recently been recognized as a possible tool among the several techniques reported for ether production. These procedures offer promising methods to selectively produce ethers with higher molecular structures, both symmetrical and asym

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12

Rao, N. Sree Lakshmana, Mandava V. Basaveswara Rao, and K. R. S. Prasad. "Synthesis and Antibacterial Evaluation of Hydrazone Derivatives Bearing 6-Chlorothieno[3,2-c]pyridine Moiety." Asian Journal of Chemistry 31, no. 3 (2019): 627–32. http://dx.doi.org/10.14233/ajchem.2019.21461.

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The present investigation describes the overall preparation of 6-chlorothieno[3,2-c]pyridine-2-carbohydrazide-hydrazone subsidiaries (7a-r) from industrially accessible ethyl-4,6-dichloronicotinate as starting material. The synthesis of these derivatives involve some prominent reactions such as (i) NaBH4 reduction of ethyl ester group (ii) MnO2 oxidation of 1º alcohol (iii) cyclization of aldehyde with ethylmercapto acetate leading to thieno[3,2-c]pyridine ring (iv) hydrazinolysis of the ethyl group (v) condensation of selected aldehydes with 6-chlorothieno[3,2-c]pyridine-2-carbohydrazide lead

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13

Arimitsu, Satoru, Kazuto Terukina та Tatsuro Ishikawa. "Stereoselective Synthesis of 4-Substituted 2,4-Dichloro-2-butenals by α- and γ-Regioselective Double Chlorination of Dienamine Catalysis". Synlett 29, № 14 (2018): 1887–91. http://dx.doi.org/10.1055/s-0037-1609559.

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The l-proline-catalyzed reaction of enolizable α,β-unsaturated aldehydes with N-chlorosuccinimide (NCS) gave the corresponding 4-substituted 2,4-dichloro-2-butenals with moderate yields and excellent diastereoselectivities (Z/E = >20/1) through consecutive double chlorination at the α- and γ-positions of the dienamine intermediate. The corresponding 2,4-dichloro-2-butenals contain a multireactive 1,3-dichloro allylic unit useful for the construction of Z-vinyl chlorides; the chloride on the allylic position was replaced with mild nucleophiles such as MeOH and EtOH via an SN2 substitution re

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14

Omar, Abdelsattar M., Osheiza Abdulmalik, Mohini S. Ghatge, et al. "An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling." Biomolecules 10, no. 11 (2020): 1508. http://dx.doi.org/10.3390/biom10111508.

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Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia-induced HbS polymerization and the subsequent erythrocyte sickling have for several years been studied for the treatment of sickle cell disease (SCD). With the exception of Voxelotor, which was recently approved by the U.S. Food and Drug Administration (FDA) to treat the disease, several other promising antisickling aromatic aldehydes have not fared well in the clinic because of metabolic instability of the aldehyde mo

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15

Zhuo, Congcong, Caifen Ou, Chuanjiang Hu та Jianping Lang. "Synthesis and characterization of β,β′-linked porphyrin-chlorin heterodimers and their metallic complexes". Journal of Porphyrins and Phthalocyanines 21, № 03 (2017): 211–21. http://dx.doi.org/10.1142/s1088424617500419.

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Two β,β′-linked porphyrin-chlorin heterodimers have been successfully synthesized with 4-fluorophenyl or 4-chlorophenyl substituted aldehyde as starting reagents. But those aldehydes with bulkier substituents did not lead to the corresponding heterodimers. These porphyrin-chlorin heterodimers and their metallic complexes have been characterized by X-ray crystallography. In all the structures, the pyrroline group in chlorin moiety and the pyrrole group in porphyrin moiety are directly connected by a single bond. Pyrroline ring has two sp[Formula: see text] hybridized carbons. The direct bonding

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16

AHVAZI, Bijan, Rene COULOMBE, Marc DELARGE, et al. "Crystal structure of the NADP+-dependent aldehyde dehydrogenase from Vibrio harveyi: structural implications for cofactor specificity and affinity." Biochemical Journal 349, no. 3 (2000): 853–61. http://dx.doi.org/10.1042/bj3490853.

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Aldehyde dehydrogenase from the bioluminescent bacterium, Vibrio harveyi, catalyses the oxidation of long-chain aliphatic aldehydes to acids. The enzyme is unique compared with other forms of aldehyde dehydrogenase in that it exhibits a very high specificity and affinity for the cofactor NADP+. Structural studies of this enzyme and comparisons with other forms of aldehyde dehydrogenase provide the basis for understanding the molecular features that dictate these unique properties and will enhance our understanding of the mechanism of catalysis for this class of enzyme. The X-ray structure of a

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17

Shim, Jae Ho, Seok Hyun Cheun, Hyeon Soo Kim та Deok-Chan Ha. "Organocatalysis for the Asymmetric Michael Addition of Aldehydes and α,β-Unsaturated Nitroalkenes". Catalysts 12, № 2 (2022): 121. http://dx.doi.org/10.3390/catal12020121.

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Michael addition is an important reaction because it can be used to synthesize a wide range of natural products or complex compounds that exhibit biological activities. In this study, a mirror image of an aldehyde and α,β-unsaturated nitroalkene were reacted in the presence of (R,R)-1,2-diphenylethylenediamine (DPEN). Herein, thiourea was introduced as an organic catalyst, and a selective Michael addition reaction was carried out. The primary amine moiety of DPEN reacts with aldehydes to form enamines, which is activated by the hydrogen bond formation between the nitro groups of α,β-unsaturate

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18

Du, Ganhong, Jun Ling, Fangyu Hu, Keyuan Liu, Long Ye, and Liming Jiang. "Bioinspired Polymer-Bound Organocatalysts for Direct Asymmetric Aldol Reaction: Experimental and Computational Studies." Catalysts 9, no. 5 (2019): 398. http://dx.doi.org/10.3390/catal9050398.

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A series of poly(2-oxazoline) (POX) derivatives bearing prolinamide pendants were designed as organocatalysts and evaluated in the direct asymmetric aldol reaction between aromatic aldehydes and cyclic ketones. The structural variation of the alkyl spacer connecting the polymer backbone with the catalytic unit was applied so as to deduce structure–performance relationships combined with comparable experiments from model catalysts. Results showed that the POX-bound prolinamides can promote the aldol reaction more effectively as compared to their small-molecular and non-POX-bound analogs. The ca

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19

Bezsudnova, Ekaterina Yu, Tatiana E. Petrova, Natalia V. Artemova, et al. "NADP-Dependent Aldehyde Dehydrogenase from Archaeon Pyrobaculum sp.1860: Structural and Functional Features." Archaea 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/9127857.

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We present the functional and structural characterization of the first archaeal thermostable NADP-dependent aldehyde dehydrogenase AlDHPyr1147. In vitro, AlDHPyr1147 catalyzes the irreversible oxidation of short aliphatic aldehydes at 60–85°С, and the affinity of AlDHPyr1147 to the NADP+ at 60°С is comparable to that for mesophilic analogues at 25°С. We determined the structures of the apo form of AlDHPyr1147 (3.04 Å resolution), three binary complexes with the coenzyme (1.90, 2.06, and 2.19 Å), and the ternary complex with the coenzyme and isobutyraldehyde as a substrate (2.66 Å). The nicotin

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20

Senthil Kumar Raju, Archana Settu, Archana Thiyagarajan, Divya Rama, Praveen Sekar, and Shridharshini Kumar. "Synthetic approaches of medicinally important Schiff bases: An updated Review." World Journal of Advanced Research and Reviews 16, no. 3 (2022): 838–52. http://dx.doi.org/10.30574/wjarr.2022.16.3.1394.

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The Schiff base defined by an imine or azomethine (-CH= N-) group, is mostly synthesized by the condensation reaction of carbonyl compounds (Aldehyde or Ketone) with compounds consisting of amine moiety. Schiff bases are among the most chiefly used organic compounds, revealing a wide range of applications, such as electroluminescent effects, fluorescence properties, nonlinear optical and chemosensory properties. The typical Schiff bases are crystalline solids that are basic, although at least some of them combine with strong acids to generate insoluble salt. Schiff bases are widely used in the

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21

Zakrzewski, Jerzy. "Reactions of nitroxides XIII: Synthesis of the Morita–Baylis–Hillman adducts bearing a nitroxyl moiety using 4-acryloyloxy-2,2,6,6-tetramethylpiperidine-1-oxyl as a starting compound, and DABCO and quinuclidine as catalysts." Beilstein Journal of Organic Chemistry 8 (September 12, 2012): 1515–22. http://dx.doi.org/10.3762/bjoc.8.171.

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22

Lee, Siyeon, Wei Wang, Younjoo Lee, and Nicole S. Sampson. "Cyclic acetals as cleavable linkers for affinity capture." Organic & Biomolecular Chemistry 13, no. 31 (2015): 8445–52. http://dx.doi.org/10.1039/c5ob01056j.

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23

Sansook, Supojjanee, Cory A. Ocasio, Iain J. Day, et al. "Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety." Organic & Biomolecular Chemistry 15, no. 40 (2017): 8655–60. http://dx.doi.org/10.1039/c7ob02289a.

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A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF<sub>5</sub>-substituted oxindoles with a range of aldehydes.

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24

Sahu, Pramod K., Praveen K. Sahu, Manvendra S. Kaurav, et al. "One-pot facile and mild construction of densely functionalized pyrimidines in water via consecutive C–C and C–S bonds formation." RSC Advances 8, no. 59 (2018): 33952–59. http://dx.doi.org/10.1039/c8ra04363a.

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Fused pyrimidines composed of alternating heteroatoms and a pyrimidine moiety were synthesized efficiently using readily available starting material 4-hydroxycoumarin, aromatic aldehydes, and urea/thiourea at room temperature.

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25

Guo, Bin, Jiang-Yan Xue, Hong-Xi Li, Da-Wei Tan, and Jian-Ping Lang. "Design of recyclable TEMPO derivatives bearing an ionic liquid moiety and N,N-bidentate group for highly efficient Cu(i)-catalyzed conversion of alcohols into aldehydes and imines." RSC Advances 6, no. 57 (2016): 51687–93. http://dx.doi.org/10.1039/c6ra10373a.

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26

Senthil, Kumar Raju, Settu Archana, Thiyagarajan Archana, Rama Divya, Sekar Praveen, and Kumar Shridharshini. "Synthetic approaches of medicinally important Schiff bases: An updated Review." World Journal of Advanced Research and Reviews 16, no. 3 (2022): 838–52. https://doi.org/10.5281/zenodo.7903785.

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The Schiff base defined by an imine or azomethine (-CH= N-) group, is mostly synthesized by the condensation reaction of carbonyl compounds (Aldehyde or Ketone) with compounds consisting of amine moiety. Schiff bases are among the most chiefly used organic compounds, revealing a wide range of applications, such as electroluminescent effects, fluorescence properties, nonlinear optical and chemosensory properties. The typical Schiff bases are crystalline solids that are basic, although at least some of them combine with strong acids to generate insoluble salt. Schiff bases are widely used in the

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27

Leleu-Chavain, Natascha, Romain Regnault, Hania Ahouari, et al. "Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents." Molecules 27, no. 10 (2022): 3316. http://dx.doi.org/10.3390/molecules27103316.

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Small molecules targeting the PD-1/PD-L1 checkpoint are actively searched to complement the anticancer arsenal. Different molecular scaffolds have been reported, including phenyl-pyrazolone derivatives which potently inhibit binding of PD-L1 to PD-1. These molecules are structurally close to antioxidant drug edaravone (EDA) used to treat amyotrophic lateral sclerosis. For this reason, we investigated the capacity of five PD-L1-binding phenyl-pyrazolone compounds (1–5) to scavenge the formation of oxygen free radicals using electron spin resonance spectroscopy with DPPH/DMPO probes. In addition

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28

Chang, Ruixue, Heng An, Xu Li, et al. "Self-healable polymer gels with multi-responsiveness of gel–sol–gel transition and degradability." Polymer Chemistry 8, no. 7 (2017): 1263–71. http://dx.doi.org/10.1039/c6py02122k.

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P(NIPAM-co-FPA) contains an aldehyde group and a phenolic ester moiety is synthesized. The aldehyde group can form reversible covalent bonds with hydrazide to endow the polymer gels with self-healing properties. The self-healable polymer gel can be degraded in Na<sub>2</sub>CO<sub>3</sub> solution based on cleavage of phenolic ester bond.

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29

Jhimli, Sengupta, and Hudait Nandagopal. "Synthesis and characterization of new carbohydrate-based organic Schiff bases." Journal of Indian Chemical Society Vol. 97, No. 11b, Nov 2020 (2020): 2477–81. https://doi.org/10.5281/zenodo.5656722.

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Department of Chemistry, West Bengal State University, Barasat, Kolkata-700 126, India <em>E</em>-<em>mail:</em> jhimli.sengupta@gmail.com <em>Manuscript received online 12 October 2020, revised and accepted 30 November 2020</em> Carbohydrate-based organic Schiff bases having biological, catalytic and pharmaceutical activities have great demand. A series of new organic Schiff bases were synthesized starting from diacetone-D-glucose following the general protocol of condensation between amine and aldehyde, either both having sugar moiety (condensation of amino sugar with aldehyde suga

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30

Barakov, Roman, Nataliya Shcherban, Oleg Petrov, et al. "MWW-type zeolite nanostructures for a one-pot three-component Prins–Friedel–Crafts reaction." Inorganic Chemistry Frontiers 9, no. 6 (2022): 1244–57. http://dx.doi.org/10.1039/d1qi01497h.

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The one-pot Prins–Friedel–Crafts reaction of aldehydes, a homoallylic alcohol and aromatics catalyzed by large-pore zeolites is an attractive environmentally friendly route towards valuable heterocyclic compounds containing a 4-aryltetrahydropyran moiety.

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31

Zainab A. Jabbar, Monther F. Mahdi, and Basma M.Abd Razik. "Synthesis, Characterization, ADME Study and Anti-proliferative evaluation against MCF-7 breast cancer cell line of new analog of a 4-aminophenyl quinazolinone derivative." Al Mustansiriyah Journal of Pharmaceutical Sciences 23, no. 4 (2023): 411–28. http://dx.doi.org/10.32947/ajps.v23i4.1096.

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New series of 4-aminophenyl quinazolinone attached to an aromatic aldehyde moiety has been designed. Compound (ZA) was synthesized by a reaction of benzene-1,4-diamine with 2-aminobenzoic acid. The reaction between (ZA) intermediate and different substituted aromatic aldehydes (R1- R6) is considered one of the most common chemical reactions for the synthesis of imine compounds (Schiff bases) to produce compound (ZA1-ZA6). FTIR, 1H-NMR, and 13C-NMR have been used to confirm the chemical structures of various substances. MTT assay was used to assess in vitro anti-proliferative action for e

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32

Marwa A. Atiyah, Olfat A. Nief, and Abdulkader M. Noori. "New Pyrazolines with Imine Moiety: Synthesis, Characterization." Tikrit Journal of Pure Science 26, no. 5 (2021): 40–47. http://dx.doi.org/10.25130/tjps.v26i5.175.

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Chalcone was prepared by claisen- schmidt condensation between reaction equivalent moles from 4-amino acetophenone with thiophen -2-carboxaldehyde in presence sodium hydroxide as base, the mechanism was involved the abstraction α Proton by base from the α-carbon of the ketone to form carbanion, which attacks carbonyl of aldehyde contains no α-hydrogens to produce α-β-unsaturated ketone, Chalcone derivative used to synthesize pyrazoline derivatives by condensation with 2,4-dinitro phenyl hydrazine. The newly synthesized compounds were determined using spectroscopic methods such as FTIR, Mass sp

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33

Narayanan, P., K. Sethusankar, Velu Saravanan, and Arasambattu K. Mohanakrishnan. "2-(4-Chloro-2-nitrophenyl)-4-methoxy-9-phenylsulfonyl-9H-carbazole-3-carbaldehyde." Acta Crystallographica Section E Structure Reports Online 70, no. 2 (2014): o230—o231. http://dx.doi.org/10.1107/s1600536814001809.

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In the sterically hindered title compound, C26H17ClN2O6S, the carbazole ring has a maximum deviation from planarity of 0.067 (4) Å for the C atom connected to the aldehyde group. The carbazole moiety forms a dihedral angle of 72.8 (1)° with the nitro-substituted benzene ring. The O atom of the methoxy group deviates by 0.186 (1) Å from the adjacent carbazole moiety. The phenylsulfonyl group forms intramolecular C—H...O bonds between sulfone O atoms and the carbazole moiety, resulting in twoS(6) rings. In the crystal, the nitrated benzene rings are linkedviaC—H...O interactions forming infinite

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34

Zosim, Tat’yana P., Rita N. Kadikova, Roman A. Novikov, Alexander A. Korlyukov, Oleg S. Mozgovoj, and Ilfir R. Ramazanov. "The TaCl5-Mediated Reaction of Dimethyl 2-Phenylcyclopropane-1,1-dicarboxylate with Aromatic Aldehydes as a Route to Substituted Tetrahydronaphthalenes." Molecules 29, no. 12 (2024): 2715. http://dx.doi.org/10.3390/molecules29122715.

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It is found that the reaction of dimethyl 2-phenylcyclopropane-1,1-dicarboxylate with 2 equivalents each of aromatic aldehydes and TaCl5 in 1,2-dichloroethane at 23 °C for 24 h after hydrolysis gives substituted 4-phenyl-3,4-dihydronaphtalene-2,2(1H)-dicarboxylates in good yield. This represents a new type of reactions between 2-arylcyclopropane-1,1-dicarboxylates and aromatic aldehydes, yielding chlorinated tetrahydronaphthalenes with a cis arrangement of the aryl and chlorine substituents in the cyclohexene moiety. A plausible reaction mechanism is proposed.

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35

Agrawal, Santosh, Nagaraju Molleti та Vinod K. Singh. "Organocatalytic enantio- and diastereoselective synthesis of highly substituted δ-lactones via a Michael-cyclization cascade". Chemical Communications 51, № 48 (2015): 9793–96. http://dx.doi.org/10.1039/c5cc02776d.

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An organocatalyzed Michael-cyclization cascade approach of α,β-unsaturated aldehydes and pyrazoleamides has been developed to get highly substituted δ-lactones in excellent enantio- and diastereoselectivities. This approach features the rearrangement of the pyrazole moiety of pyrazoleamides for the formation of δ-lactones.

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36

Özdemir, Ahmet, Gülhan Turan-Zitouni, Asim Kaplancikli, and Dilek Altintop. "Synthesis of some new hydrazone derivatives containing benzothiazole moiety." Journal of the Serbian Chemical Society 77, no. 2 (2012): 141–46. http://dx.doi.org/10.2298/jsc110321171o.

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Hydrazones are important classes of compounds found in many synthetic products. Due to their importance in synthetic chemistry, the present article reports the synthesis of a new series of ten compounds based on the coupling of 2-[2(3H)-benzothiazolone-3-yl]acetylhydrazine and 2-(1,3- benzothiazol-2-yl)sulphanylacetylhydrazine with different aldehydes. The structures of the synthesized compounds were confirmed by elemental analyses, IR, 1H-NMR, 13C-NMR and FAB+-MS spectral data.

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37

Maji, Siddhartha, Kwabena Fobi, Ebenezer Ametsetor, and Richard A. Bunce. "Domino Synthesis of 1,2,5-Trisubstituted 1H-Indole-3-carboxylic Esters Using a [3+2] Strategy." Molecules 30, no. 3 (2025): 444. https://doi.org/10.3390/molecules30030444.

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A new approach to 1,2,5-trisubstituted 1H-indole-3-carboxylic esters has been developed and studied. The method begins with the preparation of imines from aldehyde and primary amine derivatives. Treatment of these imines with the K2CO3-derived anion from methyl 2-(2-fluoro-5-nitrophenyl)acetate or methyl 2-(5-cyano-2-fluorophenyl)acetate in DMF initiates a [3+2] cyclization by addition of the anion to the imine followed by ring closure of the adduct nitrogen to the activated aromatic moiety via an SNAr process. Twenty-one examples are reported. Temperatures required for the conversion range fr

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38

Yang, Xiao Hui, Guo Min Xiao, Zhi Min Wang, Yong Hong Zhou, and Guo Dong Feng. "Antihypertensive Evaluation of Lignin Related High-Added-Value 4-Aryl-Hexahydroquinolines." Advanced Materials Research 581-582 (October 2012): 7–10. http://dx.doi.org/10.4028/www.scientific.net/amr.581-582.7.

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4-Aryl-hexahydroquinolines prepared by Hantzsch reaction from aromatic aldehydes obtained from lignin had been proved to be excellent antioxidant property. In view of polyhydroquinoline containing similarities in structure to the biologically important compound, 1,4-dihydropyridine, their antihypertensive activities were herein determined in spontaneously hypertensive rats (SHRs) during different time. The results show that those compounds possessing excellent antioxidant activity exhibit good antihypertensive property, and the compound containing syringyl moiety exhibit better antihypertensiv

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39

S., EL-BAHAEI, E. BAYOUMY E., and YOUSSIF SH. "Synthesis of some New Thienopyrimidines containing 4-Thiazolidinone Moiety." Journal of Indian Chemical Society Vol. 65, Oct 1988 (1988): 695–98. https://doi.org/10.5281/zenodo.6076748.

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Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt <em>Manuscript received 18 February 1988, accepted 8 July 1988</em> The reaction of 4-mercaptopyrimidines (1) with halogenated active methylene in aqueous sodium carbonate gave compounds 2. Compound 2c, g were allowed to react with hydrazine hydrate in ethanolts give the acid hydrazides (4a, b). The latter were condensed with aromatic aldehydes and ketones to give the corresponding hydrazones (5). Cyclocondensation of thioglycolic acid on the hydrazones (5) gave the thiazoli-dinothienopyrimidines (6).

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40

Cozzi, Pier Giorgio, Sandro Gambarotta, Magda Monari, and Luca Zoli. "Convenient Preparation of Chiral Dipyrrolylmethanes Containing a Chiral Moiety." Collection of Czechoslovak Chemical Communications 72, no. 8 (2007): 1046–56. http://dx.doi.org/10.1135/cccc20071046.

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A variety of chiral bis-pyrroles have been made readily accessible via acid-catalyzed condensation of chiral ketones with pyrrole. Three representative chiral ketones 2-4 taken from the chiral pool were transformed into the corresponding bis-pyrrole derivatives in a straightforward acid-catalyzed condensation. Chiral β-hydroxy ketone derivatives, prepared through proline-catalyzed aldol condensation of acetone and an aldehyde, are readily transformed into the corresponding dipyrrolylmethane by the acid-catalyzed condensation carried out in the same conditions. The crystal structure of the chir

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41

Mohana, Kikkeri N., and Chikkur B. Pradeep Kumar. "Synthesis and Antioxidant Activity of 2-Amino-5-methylthiazol Derivatives Containing 1,3,4-Oxadiazole-2-thiol Moiety." ISRN Organic Chemistry 2013 (August 19, 2013): 1–8. http://dx.doi.org/10.1155/2013/620718.

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A series of new 5-(2-amino-5-methylthiazol-4-yl)-1,3,4-oxadiazole-2-thiol derivatives 6(a–j) were designed and synthesized with various substituted aldehydes. The chemical structures were confirmed by elemental analyses, FT-IR, 1H NMR, and mass spectral studies. The antioxidant activity of the synthesized compounds was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl, nitric oxide, and superoxide radical scavenging assay methods. Compounds 6a, 6e, and 6c showed significant radical scavenging potential due to the presence of electron donating substituent on substituted aldehydes.

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42

Socea, Laura Ileana, Stefania Felicia Barbuceanu, Lucian Iscrulescu, et al. "New N-acylhydrazones with Potential Cytotoxic Activity." Revista de Chimie 69, no. 12 (2019): 3341–44. http://dx.doi.org/10.37358/rc.18.12.6745.

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Some new N-acylhydrazones 7a-c having dibenzo[a,d][7]annulene moiety were synthesized by condensation of corresponding hydrazide 5 with aromatic aldehydes. The structures of these newly compounds were elucidated by IR, 1H-NMR, 13C-NMR, and elemental analysis. In the view of the therapeutical potential of the newly compounds, we evaluated their toxicological profile using Daphnia magna bioassay.

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43

Dacho, Vladimír, and Peter Szolcsányi. "Synthesis and Olfactory Properties of Seco-Analogues of Lilac Aldehydes." Molecules 26, no. 23 (2021): 7086. http://dx.doi.org/10.3390/molecules26237086.

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Lilac aldehydes are considered as principal olfactory molecules of lilac flowers. We have designed, prepared, and evaluated a set of racemic seco-analogues of such natural products. The synthesis employs commercially available α-chloroketones as substrates that are transformed in four steps to target compounds. Their qualitative olfactory analysis revealed that the opening of the tetrahydrofuran ring leads to a vanishing of original flowery scent with the emergence of spicy aroma accompanied by green notes, and/or fruity aspects of novel seco-analogues. These results suggest the important osmo

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44

Belkhadem, Karima, Yihong Cao, and René Roy. "Synthesis of Galectin Inhibitors by Regioselective 3′-O-Sulfation of Vanillin Lactosides Obtained under Phase Transfer Catalysis." Molecules 26, no. 1 (2020): 115. http://dx.doi.org/10.3390/molecules26010115.

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Vanillin-based lactoside derivatives were synthetized using phase-transfer catalyzed reactions from per-O-acetylated lactosyl bromide. The aldehyde group of the vanillin moiety was then modified to generate a series of related analogs having variable functionalities in the para- position of the aromatic residue. The corresponding unprotected lactosides, obtained by Zemplén transesterification, were regioselectively 3′-O-sulfated using tin chemistry activation followed by treatment with sulfur trioxide-trimethylamine complex (Men3N-SO3). Additional derivatives were also prepared from the vanill

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45

Mithlesh, Pawan K. Pareek, Hemraj Chippa, Ravikant, and Krishan G. Ojha. "Microwave synthesis of new biologically important 1,4-dihydropyridines containing benzothiazole moiety." Collection of Czechoslovak Chemical Communications 75, no. 3 (2010): 275–87. http://dx.doi.org/10.1135/cccc2009051.

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2,3,5,6-Tetrasubstituted-4-aryl-1-(6-ethoxybenzothiazol-2-yl)-1,4-dihydropyridines were synthesized by the reaction of 2-amino-6-ethoxybenzothiazole, an aromatic aldehyde and an active methylene compound in methanol by conventional or microwave irradiation method (solvent-free or with solid support). All compounds were tested for antibacterial and antifungal activities and the results were compared with standard drugs. Their acaricidal and antifeedant activities were also tested.

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46

Wünsch, Matthias, David Schröder, Tanja Fröhr, et al. "Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics." Beilstein Journal of Organic Chemistry 13 (November 15, 2017): 2428–41. http://dx.doi.org/10.3762/bjoc.13.240.

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The amide moiety of peptides can be replaced for example by a triazole moiety, which is considered to be bioisosteric. Therefore, the carbonyl moiety of an amino acid has to be replaced by an alkyne in order to provide a precursor of such peptidomimetics. As most amino acids have a chiral center at Cα, such amide bond surrogates need a chiral moiety. Here the asymmetric synthesis of a set of 24N-sulfinyl propargylamines is presented. The condensation of various aldehydes with Ellman’s chiral sulfinamide provides chiralN-sulfinylimines, which were reacted with (trimethylsilyl)ethynyllithium to

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47

Voskressensky, Leonid, Olga Storozhenko, Alexey Festa, Roman Novikov, and Alexey Varlamov. "Synthesis of Chromenoimidazoles, Annulated with an Azaindole Moiety, through a Base-Promoted Domino Reaction of Cyanomethyl Quaternary Salts." Synthesis 49, no. 12 (2017): 2753–60. http://dx.doi.org/10.1055/s-0036-1589496.

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The reactivity of N-cyanomethyl quaternary salts of 4-, 5- and 7-azaindoles towards salicylic aldehydes has been studied. The interaction of azaindolium salts with salicylic aldehydes proceeds as a base-promoted domino reaction, giving the corresponding chromenoimidazopyrrolopyridines. In the case of the 7-(cyanomethyl)-7-azaindolium salt, the reaction was found to be more sensitive, but the use of the 1-methyl-substituted salt allowed the synthesis of the desired compounds, incorporating the heterocyclic core of isogranulatimide C, a marine natural product.

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48

Karthika, T. Swarna, and C. Mansiya. "Synthesis and Antimicrobial Activity of Azo Compounds Containing Aldehyde Moiety." Asian Journal of Research in Chemistry 11, no. 1 (2018): 129. http://dx.doi.org/10.5958/0974-4150.2018.00027.5.

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49

Kim, Sung-Hoon, Gu Won Jeong, and Young-Min Kim. "Catechol/aldehyde Moiety-based Bioadhesive Thermosensitive Poly(organophosphazenes) Hydrogel System." Polymer Korea 47, no. 2 (2023): 241–48. http://dx.doi.org/10.7317/pk.2023.47.2.241.

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50

Syed Nasir Abbas Bukhari. "Discovery of a new tetramethylpyrazine based chalcone with α, β-Unsaturated ketone moiety as a potential anticancer agent". International Journal of Research in Pharmaceutical Sciences 11, № 1 (2020): 826–29. http://dx.doi.org/10.26452/ijrps.v11i1.1901.

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In this study, a new ligustrazine-based chalcone molecule has been synthesized that contains an extra α, β-Unsaturated ketone moiety along with α, the β-Unsaturated carbonyl group of chalone. A new tetramethylpyrazine (TMP) based aldehyde was synthesized to make the TMP (ligustrazine) as part of chalcone and then it was reacted with newly synthesized ketone containing additional α, β-Unsaturated ketone moiety. After characterization, this new compound was evaluated for its effect on different types of cancer cell lines and very promising results were obtained. The growth of these cancer cells

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