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1

Buchner, Stefan, Markus Resch, Reinhard Kobuch, and Christoph Birner. "Clipping the Alfieri Stitch." JACC: Cardiovascular Interventions 9, no. 3 (February 2016): e29-e30. http://dx.doi.org/10.1016/j.jcin.2015.10.045.

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2

Källner, Göran, Jan van der Linden, Leonidas Hadjinikolaou, and Dan Lindblom. "Transaortic approach for the Alfieri stitch." Annals of Thoracic Surgery 71, no. 1 (January 2001): 378–79. http://dx.doi.org/10.1016/s0003-4975(00)02186-x.

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3

Alfieri, Ottavio, and Paolo Denti. "Alfieri stitch and its impact on mitral clip." European Journal of Cardio-Thoracic Surgery 39, no. 6 (June 2011): 807–8. http://dx.doi.org/10.1016/j.ejcts.2011.01.017.

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4

Morimoto, Hironobu, Koji Tsuchiya, Masato Nakajima, Yoshitaka Mitsumori, and Kaori Kato. "Chordal Replacement with Temporary Alfieri Stitch for Anterior Leaflet Prolapse." Asian Cardiovascular and Thoracic Annals 15, no. 6 (December 2007): 531–33. http://dx.doi.org/10.1177/021849230701500620.

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5

Sherlock, Katrina E., Ganapathy Muthuswamy, Rahul Basu, and Ian M. Mitchell. "The Alfieri Stitch: The Advantages for Mitral Valve Repair in Difficult Circumstances." Journal of Cardiac Surgery 26, no. 5 (August 31, 2011): 475–77. http://dx.doi.org/10.1111/j.1540-8191.2011.01295.x.

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6

Basaran, M., O. Selimoglu, T. Yildirim, and N. Temucin Ogus. "Use of Alfieri stitch technique in a patient with hypertrophic obstructive cardiomyopathy." Interactive CardioVascular and Thoracic Surgery 5, no. 6 (August 25, 2006): 738–39. http://dx.doi.org/10.1510/icvts.2006.137588.

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7

Akiyama, Koichi, Keiichi Itatani, Yoshifumi Naito, Mao Kinoshita, Masaru Shimizu, Saeko Hamaoka, Hiroaki Yasumoto, et al. "Vector Flow Mapping and Impaired Left Ventricular Flow After the Alfieri Stitch." Journal of Cardiothoracic and Vascular Anesthesia 31, no. 1 (February 2017): 211–14. http://dx.doi.org/10.1053/j.jvca.2016.07.013.

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8

Khan, Jaffar M., Robert J. Lederman, Saurabh Sanon, Bradley G. Leshnower, Altayyeb Yousef, Patrick Gleason, Stamatios Lerakis, Toby Rogers, Adam B. Greenbaum, and Vasilis C. Babaliaros. "Transcatheter Mitral Valve Replacement After Transcatheter Electrosurgical Laceration of Alfieri STItCh (ELASTIC)." JACC: Cardiovascular Interventions 11, no. 8 (April 2018): 808–11. http://dx.doi.org/10.1016/j.jcin.2017.11.035.

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9

Fathima, Samreen, Shelley A. Hall, Paul A. Grayburn, and William C. Roberts. "The Mitral Valve 16 Months After Operative Insertion of the Alfieri Stitch." American Journal of Cardiology 123, no. 4 (February 2019): 695–96. http://dx.doi.org/10.1016/j.amjcard.2018.11.005.

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10

Shah, Asad A., Donald D. Glower, and Jeffrey G. Gaca. "Trans-aortic Alfieri stitch at the time of septal myectomy for hypertrophic obstructive cardiomyopathy." Journal of Cardiac Surgery 31, no. 8 (July 11, 2016): 503–6. http://dx.doi.org/10.1111/jocs.12804.

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11

Fukunaga, Naoto, and Tadaaki Koyama. "Trans-aortic Alfieri stitch at the time of septal myectomy for hypertrophic obstructive cardiomyopathy." Journal of Cardiac Surgery 31, no. 11 (September 7, 2016): 692. http://dx.doi.org/10.1111/jocs.12838.

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12

Tan, F., K. L. Kerk, T. E. Tan, C. Sivathasan, D. Sim, and C. P. Lim. "Concomitant Alfieri Stitch Mitral Valve Repair in Patients Undergoing Left Ventricular Assist Device Implantation." Journal of Heart and Lung Transplantation 38, no. 4 (April 2019): S350. http://dx.doi.org/10.1016/j.healun.2019.01.890.

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13

Rassaf, Tienush. "The cardiologist’s way to do the Alfieri stitch: transcatheter mitral valve edge-to-edge repair revisited." Journal of Thoracic Disease 9, no. 12 (December 2017): 4832–34. http://dx.doi.org/10.21037/jtd.2017.10.134.

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14

Khan, Jaffar, Robert Lederman, Saurabh Sanon, Bradley Leshnower, Altayyeb Yousef, Patrick Gleason, Stamatios Lerakis, Toby Rogers, Adam Greenbaum, and Vasilis Babaliaros. "TCT-484 Electrosurgical Laceration of Alfieri Stitch (ELASTIC) to Facilitate Transcatheter Mitral Valve Replacement: First-in-Human Report." Journal of the American College of Cardiology 72, no. 13 (September 2018): B193—B194. http://dx.doi.org/10.1016/j.jacc.2018.08.1659.

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15

Garcia, Santiago, Mackenzie Mbai, Rosemary Kelly, and Stefan Bertog. "Simultaneous transfemoral transcatheter aortic valve replacement and trans-septal mitral valve-in-ring implantation after partial laceration of an Alfieri stitch." Catheterization and Cardiovascular Interventions 93, no. 3 (September 23, 2018): 559–61. http://dx.doi.org/10.1002/ccd.27875.

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16

Rimac, Goran, Dimitri Kalavrouziotis, Jonathan Beaudoin, Josep Rodés-Cabau, and Jean-Michel Paradis. "Second Time’s a Charm: Percutaneous Edge-to-Edge Repair With the MitraClip Device as Rescue Therapy After a Failed Surgical Edge-to-Edge Alfieri Stitch." Canadian Journal of Cardiology 34, no. 9 (September 2018): 1233.e1–1233.e3. http://dx.doi.org/10.1016/j.cjca.2018.05.004.

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17

Santana, Orlando, and Joseph Lamelas. "Minimally Invasive Transaortic Repair of the Mitral Valve." Heart Surgery Forum 14, no. 4 (August 22, 2011): 232. http://dx.doi.org/10.1532/hsf98.20101133.

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<p><b>Objective:</b> We retrospectively evaluated the results of an edge-to-edge repair (Alfieri stitch) of the mitral valve performed via a transaortic approach in patients who were undergoing minimally invasive aortic valve replacement.</p><p><b>Methods:</b> From January 2010 to September 2010, 6 patients underwent minimally invasive edge-to-edge repair of the mitral valve via a transaortic approach with concomitant aortic valve replacement. The patients were considered to be candidates for this procedure if they were deemed by the surgeon to be high-risk for a double valve procedure and if on preoperative transesophageal echocardiogram the mitral regurgitation jet originated from the middle portion (A2/P2 segments) of the mitral valve.</p><p><b>Results:</b> There was no operative mortality. Mean cardiopulmonary bypass time was 137 minutes, and mean cross-clamp time was 111 minutes. There was a significant improvement in the mean mitral regurgitation grade, with a mean of 3.8 preoperatively and 0.8 postoperatively. The ejection fraction remained stable, with mean preoperative and postoperative ejection fractions of 43.3% and 47.5%, respectively. Follow-up transthoracic echocardiograms obtained at a mean of 33 days postoperatively (range, 8-108 days) showed no significant worsening of mitral regurgitation.</p><p><b>Conclusion:</b> Transaortic repair of the mitral valve is feasible in patients undergoing minimally invasive aortic valve replacement.</p>
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18

Mihos, Christos G., Maiteder Larrauri-Reyes, Judy Hung, and Orlando Santana. "Transaortic Edge-To-Edge Repair for Functional Mitral Regurgitation during Aortic Valve Replacement: A 13-Year Experience." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 11, no. 6 (November 2016): 425–29. http://dx.doi.org/10.1097/imi.0000000000000306.

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Objective The study evaluated the feasibility of a transaortic edge-to-edge mitral valve repair (Alfieri stitch) for moderate or greater (≥2+) functional mitral regurgitation (MR) in high-risk patients undergoing aortic valve replacement. Methods We retrospectively evaluated 40 consecutive patients who underwent aortic valve replacement combined with a transaortic edge-to-edge mitral valve repair for 2+ or greater functional MR, between February 2002 and April 2015. The MR was graded semiquantitatively as 0 (trace/none), mild moderate (2+), or moderate to severe (3–4+). Results Thirty-two patients had aortic stenosis, and eight had aortic regurgitation. The mean ± standard deviation (SD) age was 77.5 ± 5 years, 34 (85%) were male, and the mean ± SD EuroSCORE II was 14.3% ± 12.9. At a median follow-up of 1 month (interquartile range, 0.75–10), there were significant improvements in preoperative versus postoperative median MR grade (3+ vs 1+, P < 0.001), mean left ventricular ejection fraction (34% vs 41%, P = 0.018), left ventricular end-diastolic diameter (54 vs 49 mm, P = 0.005), and pulmonary artery systolic pressure (49 vs 35 mm Hg, P < 0.001). Persistent 3 to 4+ MR occurred in two patients (5%). In 12 patients with at least 6-month follow-up (mean ± SD, 18 ± 11 months), a sustained improvement in all echocardiographic parameters was observed, with persistent 3 to 4+ MR occurring in one patient (8.3%). Actuarial survival at 1, 3, and 4.5 years was 82% ± 6, 71% ± 8, and 65% ± 10, respectively. Conclusions A transaortic edge-to-edge repair for 2+ or greater functional MR can be safely performed during aortic valve replacement and is associated with improvements in MR grade, left ventricular remodeling, and pulmonary hemodynamics.
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19

Pereda, Daniel, Yan Topilsky, Rick A. Nishimura, and Soon J. Park. "Asymmetric Alfieri's stitch to correct systolic anterior motion after mitral valve repair." European Journal of Cardio-Thoracic Surgery 39, no. 5 (May 2011): 779–81. http://dx.doi.org/10.1016/j.ejcts.2010.08.040.

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20

Schueler, Robert, Nikos Werner, Georg Nickenig, and Christoph Hammerstingl. "Catheter-based complete “Alfieri-Stich” via interventional annuloplasty and edge-to-edge repair for degenerative mitral regurgitation." European Heart Journal 37, no. 27 (February 2, 2016): 2201. http://dx.doi.org/10.1093/eurheartj/ehv765.

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21

Forcillo, Jessica, and Vinod H. Thourani. "Commentary: Indication Creep: Rebranding the Alfieri Stitch During Aortic Surgery." Seminars in Thoracic and Cardiovascular Surgery, June 2021. http://dx.doi.org/10.1053/j.semtcvs.2021.06.021.

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22

Morimoto, Yoshihisa, and Takaki Sugimoto. "Alfieri stitch for temporary severe functional mitral regurgitation after aortic valve replacement." Surgical Case Reports 4, no. 1 (January 8, 2018). http://dx.doi.org/10.1186/s40792-017-0410-3.

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23

Nakajima, Hiroyuki, Chiho Tokunaga, Jun Hayashi, Akitoshi Takazawa, Akihiro Yoshitake, and Atsushi Iguchi. "Trapezoidal resection of an elongated anterior mitral leaflet and Alfieri stitch in hypertrophic cardiomyopathy." Journal of Cardiothoracic Surgery 15, no. 1 (October 12, 2020). http://dx.doi.org/10.1186/s13019-020-01361-2.

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Abstract Background In individuals with hypertrophic obstructive cardiomyopathy, elongated anterior mitral leaflets are commonly associated with systolic anterior motion. In patients with mild septal hypertrophy, a myectomy is considered insufficient to relieve systolic anterior motion and left ventricular outflow tract obstruction. Case presentation In the patient, who had relatively mild septal hypertrophy, the section of the anterior leaflet protruding into the left ventricular outflow tract was resected, concomitant with septal myectomy and the relocation of the papillary muscles. An edge-to-edge stitch was placed at the uppermost segment of the coaptation zone. Using these manoeuvres, systolic anterior motion, left ventricular outflow tract obstruction and mitral regurgitation were successfully resolved postoperatively. Conclusions We describe a surgical technique with an edge-to-edge suture for the resection of an elongated anterior mitral leaflet. In combination with septal myectomy and relocation of the papillary muscles, this technique is a simple and viable option, especially when septal hypertrophy is not severe.
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24

Nielsen, Sten Lyager, Tomasz A. Timek, David T. Lai, George T. Daughters, David Liang, J. Michael Hasenkam, Neil B. Ingels, and D. Craig Miller. "Edge-to-Edge Mitral Repair." Circulation 104, suppl_1 (September 18, 2001). http://dx.doi.org/10.1161/circ.104.suppl_1.i-29.

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Background Edge-to-edge approximation of the mitral valve leaflets (Alfieri procedure) is a novel surgical treatment for patients with ischemic mitral regurgitation (IMR). Long-term durability may be limited if abnormal mitral leaflet stresses result from this procedure. The aim of the current study was to measure Alfieri stitch tension (F A ) and to explore its geometric determinants in an ovine model of acute IMR as a reflection of the mitral leaflet stresses imposed by the procedure. Methods and Results Eight sheep were studied immediately after surgical placement of (1) a force transducer interposed between sutures approximating the central leaflet edges and (2) radiopaque markers around the mitral annulus and leaflet edges. Computer-aided analysis of videofluorograms was used to obtained 3D marker coordinates. Simultaneous measurements of F A , septal-lateral annular dimension (L S-L ), leaflet edge separation (L SEP ), anterior (L AL ) and posterior (L PL ) leaflet length, and hemodynamic variables were obtained at baseline (CTL) and during acute IMR (circumflex artery occlusion). F A was significantly elevated throughout the cardiac cycle during IMR compared with CTL, with maximum F A in diastole (0.26±0.05 versus 0.46±0.08 N, CTL versus IMR; P <0.05). Multivariable analysis revealed L S-L as the single independent predictor of maximum F A ( P <0.001). Positive linear correlations were shown between values of F A and L AL and L PL (dependent variables). Conclusions These experimental data demonstrate higher F A during IMR and cyclic changes in F A closely paralleling changes in L S-L , eg, being greatest in diastole when the annulus is largest. Increased F A during IMR is probably indicative of successful therapeutic intent, but higher diastolic leaflet stresses resulting from persistent or progressive mitral annular dilatation may adversely affect repair durability. This indirectly implies that concomitant mitral ring annuloplasty should be added to the Alfieri repair.
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25

Babliak, O. D., V. M. Demianenko, D. Y. Babliak, A. I. Marchenko, K. A. Revenko, and L. V. Pidgaina. "Right Minithoraсotomy as a Standard Approach for Mitral Valve Surgery." Ukrainian journal of cardiovascular surgery, February 11, 2020, 23–28. http://dx.doi.org/10.30702/ujcvs/20.3803/013023-028.

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Background. Minimally invasive mitral valve surgery provides many advantages for patients. The aim. To investigate and represent our own experience in minimally invasive mitral valve surgery, and to describe the operative technique. Materials and methods. The study was included 100 consecutive patients who underwent a minimally invasive mitral valve repair or replacement through the right lateral minithoracotomy from June 2017 to December 2019. Results. Mitral valve repair was performed in 87 patients (87%), and 13 patients (13%) were required mitral valve replacement. In 24 patients (24%), concomitant procedures were performed: tricuspid valve repair, atrial septal defect repair and left atrial myxomectomy. Ring anuloplasty was performed in all patients who underwent mitral valve repair. Additional methods of correction were used in accordance to the lesion anatomy: neochords implantation, cleft and leaflet perforation closure, leaflet resection, Alfieri (edge-to-edge) stitch, posterior leaflet plication. There was no in-hospital and 30-day mortality. Post-operative strokes were not reported. No wound complications were observed in the femoral cannulation area. The total length of stay in a hospital was 6 ± 1.46 (3–9) days. There were no cases of mitral valve insufficiency greater more than mild degree after mitral valve repair at the time of discharge. Conclusions. Minimally invasive mitral valve surgery can be performed as a routine standard approach, provides safe and effective correction of the mitral valve defects, allows excellent results of mitral valve repair and replacement in various abnormalities. Minimally invasive approach enables to perform a large number of reconstructive valve techniques and perform simultaneous correction of atrial septal defects, tricuspid valve repair and atrial neoplasm removal.
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26

Papadopoulos, K., I. Ikonomidis, M. Chrissoheris, A. Chalapas, P. Kourkoveli, G. Pattakos, P. Vardas, and K. Spargias. "P1560 Acute changes of mitral annular dimensions after transcatheter egde-to-edge repair: an indirect annuloplasty method?" European Heart Journal - Cardiovascular Imaging 21, Supplement_1 (January 1, 2020). http://dx.doi.org/10.1093/ehjci/jez319.981.

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Abstract Background Percutaneous edge-to-edge mitral valve repair (PMVR) is a safe and alternative method for treating high-risk patients with severe mitral regurgitation (DMR or FMR). This transcatheter treatment aims at reducing the MR with a so-called "Alfieri stitch" method. However the impact on mitral annular dimensions after the device implantation is not well defined. The purpose of this study is to recognize the acute changes of mitral annular dimensions after transcatheter edge-to-edge repair. Methods We retrospectively analyzed 20 consecutive patients (aged 74 ± 10yrs) with degenerative or functional moderate-to-severe and severe mitral regurgitation (EROA 40.8 ± 20.5mm2, RV 52.6 ± 17.5ml) and reduced ejection fraction (EF 36.9 ± 15.4%). These patients were at high surgical risk or even inoperable in certain cases (logistic EuroSCORE 28.9 ± 18.2%) and evaluated by a heart team as candidates for transcatheter repair. All intraoperative transoesophageal echo studies were post processed with EchoPac v.203 or QLAB 9.0. 3D views of the mitral valve before and after the implantation of the device were analyzed with 4D AutoMVQ (GE) or MVQ (Phillips) software. Results PMVR was effective in treating the MR at the end of the operation (from 3.8 ± 0.4 to 1.3 ± 0.5 after the implantation, p &lt; 0.05) in all patients. There was a significant reduction of the annulus area (from 12.25 ± 3.0cm2 to 10.18 ± 2.88cm2, p &lt; 0.001) and circumference (from 13.23 ± 1.4cm to 12.18 ± 1.57cm, p &lt; 0.001), in both DMR and FMR cases. The percentage reduction of annulus area and circumference after PMVR was 17.3 ± 0.8% and 8 ± 5% respectively and the number of the clips used for that purpose were 1.55 ± 0.6. Additionally, edge-to-edge repair significantly reduced the anterior-posterior diameter (from 3.49 ± 0.56cm to 3.02 ± 0.55cm, r = 0.86, p &lt; 0.001) and the posteromedial-anterolateral diameter (from 4.15 ± 0.58cm to 3.88 ± 0.60cm, r = 0.9, p &lt; 0.001). The number of the clips used did not play an important role in the percentage difference of the annulus dimensions (20% reduction with one clip vs 14.3 ± 7.6% with two or more, p &lt; 0.05) and one possible explanation could be that patients receiving one clip had smaller annulus area comparing to the patients receiving two or more (11.2 ± 2.9mm2 vs 13.3 ± 2.7mm2 respectively, p &lt; 0.05). Conclusions Transcatheter edge-to-edge repair is effective in treating MR in patients with DMR and FMR and has a direct impact on mitral annular dimensions acutely after the implantation.
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27

Greco, Cosimo Angelo, Salvatore Nicolardi, Federica Mangia, Salvatore Zaccaria, and Giovanni Casali. "Congenital double orifice mitral valve or surgical Alfieri stich?" European Heart Journal - Cardiovascular Imaging, June 24, 2020. http://dx.doi.org/10.1093/ehjci/jeaa191.

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