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Dissertations / Theses on the topic 'Alginate hydrogel'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Tabriz, Atabak Ghanizadeh. "3D biofabrication of cell-laden alginate hydrogel structures." Thesis, Heriot-Watt University, 2017. http://hdl.handle.net/10399/3370.

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Biofabrication has been receiving a great deal of attention in tissue engineering and regenerative medicine either by manual or automated processes. Different automated biofabrication techniques have been used to produce cell-laden alginate hydrogel structures, especially bioprinting approaches. , These approaches have been limited to 2D or simple 3D structures, however. In this thesis, a new extrusion-based bioprinting technique and a new simple, manual 3D biofabrication method are presented to culture cells in 3D. These methods do not rely on any complex fabrication methods. The bioprinting

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2

Barbier, Lucile. "Hydrogels injectables thermostimulables : relations structure/propriétés." Electronic Thesis or Diss., Sorbonne université, 2022. http://www.theses.fr/2022SORUS394.

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Ce travail de thèse porte sur le développement d’hydrogels injectables thermostimulables. Dans le cadre de la délivrance de principes actifs, l’objectif est de partir d’une solution de polymère suffisamment fluide à température ambiante pour pouvoir être injectée à un endroit ciblé du corps et d’obtenir une gélification rapide de la formulation une fois introduite en milieu physiologique. Pour aborder cette étude, une large plateforme de copolymères greffés a été développée à partir de squelettes hydrophiles et de greffons thermosensibles caractérisées par leur LCST en milieu aqueux. Dans un p

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3

Gielink, Celene. "Photodegradation kinetics of curcumin in ethanol solution and encapsulated in alginate-pectin hydrogel." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1587044962123771.

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4

Vallée, Frédéric. "Synthèse et caractérisation d'un hydrogel d'alginamide pour la régénération de voies nerveuses lésées au sein du Système Nerveux Central chez le rat." Thesis, Vandoeuvre-les-Nancy, INPL, 2007. http://www.theses.fr/2007INPL110N/document.

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Ce travail avait pour objectif la synthèse d’hydrogels d’alginates stables dans le temps et leur évaluation comme support de régénération des voies nerveuses lésées du Système Nerveux Central. Différents dérivés amphiphiles de l’alginate de sodium ont été préparés en fixant chimiquement des chaînes alkyles en C12 à différents taux sur le squelette polymère par l’intermédiaire, soit de liaisons ester (alginates esters), soit de liaisons amide (alginamides) moins sensibles à l’hydrolyse. Le comportement en solution des alginamides a été étudié en termes de stabilité dans le temps, de solubilité,

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5

Viera, Rey Denis Fabricio. "Chondrocytes Encapsulation In Hydrogel Beads and Their Response to Polyphosphate Incorporation." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40702.

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In Canada, one in five people suffers from arthritis, of which the most common type is osteoarthritis (OA). OA is a group of joint diseases that cause pain and loss of range of motion and for which there is currently no cure. OA can be caused by numerous factors such as aging, genetics, environmental elements, and abnormal joint biomechanics (e.g., injury, obesity). These diseases are degenerative and lead to the progressive breakdown of joint cartilage, as well as changes in the underlying bone and other tissues of the joint over a period of years to decades. Articular cartilage incorporates

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6

Araujo, Luciana Santos de. "Preparação e avaliação de hidrogéis nanocompósitos à base de alginato na remoção de Cu (II) e Zn (II) de soluções aquosas." Universidade do Estado do Rio de Janeiro, 2014. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6531.

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Esta dissertação teve como objetivo, a preparação de hidrogéis à base de alginato contendo argila e material magnético em sua estrutura. Foram analisadas as modificações nas características físico-químicas dos hidrogéis preparados com diferentes reticulantes (CaCl2 e FeCl3) e diferentes concentrações de material magnético (1 e 3 % m/m) e argila (1, 5 e 10 %). Após isso, os hidrogéis foram avaliados quanto à capacidade de remoção de íons Cu2+ e Zn2+ de soluções aquosas. As amostras foram caracterizadas quanto à composição química por espectroscopia na região do infravermelho (FTIR), quanto à mo

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7

Ghadban, Ali. "Synthèse et caractérisation de glycopolymères à base d'oligoalginates en milieu aqueux." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00923140.

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La synthèse de glycomonomères à base d'oligoalginate (AlgiMERs) et leur polymérisations conventionnelles et RAFT en solution aqueuse ont été étudiés. Premièrement, l'oligoalginates de départ ont été transformés soit dans le glycosylamines correspondant ou en amino alditols (via une amination réductrice). A cette étape, l'optimisation des protocoles d'amination ont été identifiées par la réalisation d'une étude systématique sur un simple acide uronique (acide D-glucuronique). Deuxièmement, les sucres aminés ont été obtenus a réagi avec une électrophile portant un groupe vinyle polymérisable à c

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Mottet, Léopold. "Hydrogel composite conducteur pour l'encapsulation de bactéries électroactives." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066583/document.

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Ce travail de thèse est principalement axé sur la création d'un nouveau réacteur biocompatible permettant l'encapsulation et l'étude de bactéries électroactives. Ce compartiment de taille millimétrique, réalisé par coextrusion, est une capsule à coeur liquide possédant une membrane d'hydrogel conducteur. La synthèse de ce bioréacteur a nécessité la formulation d'un hydrogel composite alginate/nanotubes de carbone en deux étapes. Une première étape rapide crée la matrice d'hydrogel par diffusion d'ions divalents dans un mélange Alginate/nanotubes de carbone. Une seconde étape, plus lente, perme

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Küppers, Markus. "NMR-Bildgebung an fallenden Filmen und reaktiven Gelkugeln." Aachen Shaker, 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=977864367.

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Sehil, Hafida. "Elaboration de polymères naturels à base de Polysaccherides pour application à la libération controlée." Thesis, Normandie, 2017. http://www.theses.fr/2017NORMR112.

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Ce travail a eu pour objectif la conception de nouveau matériaux à base de polysaccharide pour la libération contrôlée de principes actifs et pour d'éventuelles applications environnementales. Pour cela, des gels ont été préparés par réticulation du carboxymethylepullulane CMP et du pullulane interpénétré par l’alginate avec le sodium trimétaphosphate STMP. Les hydrogels obtenus ont été caractérisés et leurs propriétés physico-chimiques et rhéologiques ont été investiguées. La séquestration de principes actifs modèles dans les hydrogels a été réalisée par regonflement des gels dans une solutio

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Guo, Jingxin. "Encapsulation of anthocyanins in alginate-pectin hydrogel particles and modeling the release at low and high pH." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1502976253714262.

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12

Karasinski, Michael A. "Manufacturing Microfluidic Flow Focusing Devices For Stimuli Responsive Alginate Microsphere Generation And Cell Encapsulation." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/756.

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In this paper a novel stimuli responsive hydrogel material, methacrylated sodium alginate beta-cyclodextrin (Alg-MA-β-CD), was used in combination with a microfluidic device to create microspheres. Currently there is no reliable method for fabricating homogeneous stimuli-responsive microspheres, in-house microfluidic devices are not reliable in manufacture quality or long-term use. Alginate hydrogels have many attractive characteristics for bioengineering applications and are commonly used to mimic the features and properties of the extracellular matrix (ECM). Human mesenchymal stem cells (hMS

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13

Wang, Zhengmu. "Design, fabrication and characterization of a double-network alginate-pHEMA hydrogel coating for PDMS-based biomedical implants." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61102.

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Traditional silicone biomedical implants, such as urinary catheters, often suffer from high surface friction, high stiffness, and a lack of hydrophilicity, which can cause discomfort or discomfort. To tackle these challenges, we developed a double-network alginate-pHEMA hydrogel “cushion” coating for polydimethylsiloxane (PDMS) biomedical implants. The double-network hydrogel presented here consists of two distinct networks made of alginate and pHEMA, respectively. The alginate network is covalently bonded to PDMS substrates as scaffolding, and the denser pHEMA network fills the free space wit

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Baixe, Sébastien. "Développement d’un hydrogel injectable à propriétés antimicrobiennes pour la prévention des péri-implantites." Thesis, Strasbourg, 2019. https://publication-theses.unistra.fr/restreint/theses_doctorat/2019/Baixe_Sebastien_2019_ED182.pdf.

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Les maladies périimplantaires sont des pathologies inflammatoires d’origine bactérienne impliquant les bactéries parodontopathogènes et surtout P.gingivalis. Elles évoluent parfois en périimplantite, avec une destruction des tissus vivants environnants. Les traitements chirurgicaux ou adjuvants (antibiotique à large spectre, antiseptiques) échouent parfois car la connectique implantaire est un véritable réservoir bactérien inaccessible au nettoyage, et situé en regard de tissus fragiles. Le développement d’un gel préventif antimicrobien à injecter dans la connectique est un véritable enjeu pou

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Galli, Roberta, Kerim H. Sitoci-Ficici, Ortrud Uckermann, et al. "Label-free multiphoton microscopy reveals relevant tissue changes induced by alginate hydrogel implantation in rat spinal cord injury." Nature Publishing Group, 2018. https://tud.qucosa.de/id/qucosa%3A33808.

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The development of therapies promoting recovery after spinal cord injury is a challenge. Alginate hydrogels offer the possibility to develop biocompatible implants with mechanical properties tailored to the nervous tissue, which could provide a permissive environment for tissue repair. Here, the effects of non-functionalized soft calcium alginate hydrogel were investigated in a rat model of thoracic spinal cord hemisection and compared to lesioned untreated controls. Open field locomotion tests were employed to evaluate functional recovery. Tissue analysis was performed with label-free multiph

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Leslie, Shirae. "The controlled release of rat adipose-derived stem cells from alginate microbeads for bone regeneration." Thesis, Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/48946.

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Cell-based therapies have potential for tissue regeneration but poor delivery methods lead to low viability or dispersal of cells from target sites, limiting clinical utility. Here, we developed a degradable and injectable hydrogel to deliver stem cells for bone regeneration. Alginate microbeads <200µm are injectable, persist at implantation sites and contain viable cells, but do not readily degrade in-vivo. We hypothesized that controlled release of rat adipose-derived stem cells (ASCs) from alginate microbeads can be achieved by incorporating alginate-lyase in the hydrogel. Microbeads were f

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Hunt, Nicola Claire. "An alginate hydrogel matrix for the localised delivery of a fibroblast/ keratinocyte co-culture to expedite wound healing." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/1383/.

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There is a clinical need for effective alternative skin replacements to autografts, allografts and xenografts. In this thesis a bi-layer skin graft was developed by encapsulation of fibroblasts in calcium-alginate hydrogel and culture of keratinocytes on the surface. Initially, the use of 5% and 2% w/v alginate hydrogels were investigated. Both scaffolds maintained fibroblast viability for at least 150 days encapsulation and caused reversible mitotic and catabolic inhibition, as assessed by fluorescent staining, immunochemistry and the thiazolyl blue assay. Sustained expression of angiogenic f

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Case, Natasha D. "Oscillatory Compressive Loading Effects On Mesenchymal Progenitor Cells Undergoing Chondrogenic Differentiation In Hydrogel Suspension." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6939.

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Articular cartilage functions to maintain joint mobility. The loss of healthy, functional articular cartilage due to osteoarthritis or injury can severely compromise quality of life. To address this issue, cartilage tissue engineering approaches are currently in development. Bone marrow-derived mesenchymal progenitor cells (MPCs) hold much promise as an alternative cell source for cartilage tissue engineering. While previous studies have established that MPCs from humans and multiple other species undergo in vitro chondrogenic differentiation, additional research is needed to define condit

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Etter, Jennifer. "Development And Characterization Of Multi-Crosslinking Injectable Hydrogels For Use In Cell And Drug Delivery." ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/991.

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Injectable hydrogels are important for use in tissue engineering due to their permeability and biocompatibility. Those that have shear thinning properties allow for minimally-invasive surgical procedures and a way to administer bioactive agents, and therapeutic cells by injection. Currently available injectable hydrogels have a single or dual input/stimulus for crosslinking which limits the range of mechanical properties and often utilize potentially toxic ultraviolet radiation that reduces viability of injected cells. To overcome these shortcomings, a tri-stimuli-responsive alginate-based inj

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Zehnder, Tobias [Verfasser], and Aldo R. [Gutachter] Boccaccini. "Biofabrication of Alginate-Based Hydrogel Constructs and Hybrid Scaffold Structures for Tissue Engineering / Tobias Zehnder ; Gutachter: Aldo R. Boccaccini." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2017. http://d-nb.info/1140228560/34.

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Deng, X., B. Huang, Q. Wang, et al. "A mussel-inspired antibacterial hydrogel with high cell affinity, toughness, self-healing, and recycling properties for wound healing." ACS PUBLICATION, 2021. http://hdl.handle.net/10454/18387.

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Yes<br>Antibacterial hydrogels have been intensively studied due to their wide practical potential in wound healing. However, developing an antibacterial hydrogel that is able to integrate with exceptional mechanical properties, cell affinity, and adhesiveness will remain a major challenge. Herein, a novel hydrogel with antibacterial and superior biocompatibility properties was developed using aluminum ions (Al3+) and alginate− dopamine (Alg-DA) chains to cross-link with the copolymer chains of acrylamide and acrylic acid (PAM) via triple dynamic noncovalent interactions, including coo

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Fitzgerald, Martha Moore. "Development and 3D Printing of Interpenetrating Network Hydrogel Materials for use as Tissue-Mimetic Models." Miami University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=miami1430488189.

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Vardar, Elif. "Investigation Of Cell Migration And Proliferation In Agarose Based Hydrogels For Tissue Engineering Applications." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612191/index.pdf.

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Hydrogels are three dimensional, insoluble, porous and crosslinked polymer networks. Due to their high water content, they have great resemblance to natural tissues, and therefore, demonstrate high biocompatibility. The porous structure provides an aqueous environment for the cells and also allows influx of nutrients needed for cellular viability. In this study, a natural biodegradable material, agarose (Aga), was used and semi-interpenetrating networks (semi-IPN) were prepared with polymers having different charges, such as positively charged chitosan (Ch) and negatively charged alginate (Alg

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Mikolášová, Kristýna. "Studium bariérových a transportních vlastností vybraných polyelektrolytů v hydrogelových matricích pomocí difúzních technik." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2017. http://www.nusl.cz/ntk/nusl-316195.

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This diploma thesis was focused on study of barrier and transport properties of selected polyelectrolytes in hydrogel matrices by using diffusion techniques. The study of these properties was performed in horizontal diffusion cells where is observed the change in diffusion probe concentration over time. Diffusion experiments were performed on an agarose hydrogel with the addition of alginate, hyaluronic acid, polystyrene sulfonate, humic acids and as a model probe rhodamine 6G was used. Important parts of this thesis are also the methods which characterize the substances and hydrogel matrices

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Bittencourt, Rodrigo Ferreira. "Síntese e avaliação de hidrogéis à base de alginato e nanopartículas magnéticas preparadas in situ para remoção de Mn(II) e Ni(II) de efluente industrial." Universidade do Estado do Rio de Janeiro, 2015. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8935.

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Esta Dissertação teve como objetivo,a síntese de hidrogéis à base de alginato e nanopartículas magnéticas (maghemita) preparadas in situ. Os hidrogéis foram preparados em diferentes concentrações de alginato de sódio (2 e 3% m/v), FeSO4 (0,3 e 0,5 mol L-1) e CaCl2 (0,1 e 0,3 mol L-1). As propriedades físico-químicas dos hidrogéis foram analisadas e, posteriormente, foram avaliados quanto à capacidade de remoção de íons Ni2+ e Mn2+ de soluções aquosas. Para caracterização das amostras foram utilizadas diversas técnicas de análises, tais como, análise granulométrica, microscopia óptica (OM), mic

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Ben, Messaoud Ghazi. "Structuration et contrôle de l’architecture de capsules à coeur liquide à base d’hydrogel d’alginate par association de biopolymères." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0327/document.

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Cette thèse a pour objectif d’étudier les propriétés physico-chimiques de capsules à cœur liquide à base d'hydrogel d'alginate et de contrôler leur perméabilité et propriétés mécaniques par ajout des biopolymères. Ces capsules sont préparées par un procédé de sphérification inverse par extrusion goutte à goutte d’une solution de chlorure de calcium dans un bain à base d’alginate. Dans un premier travail, l’influence des polymères utilisés pour contrôler la viscosité du cœur liquide lors de la préparation des capsules sur la perméabilité et la stabilité mécanique a été étudiée. Les propriétés m

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Shi, Shuai. "Development of experimental protocols for a heterogeneous bioscaffold-chondrocyte construct with application to a tissue engineered spinal disc." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271444483.

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Leslie, Shirae. "An Injectable Stem Cell Delivery System for Treatment of Musculoskeletal Defects." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4472.

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The goal of this research was to develop a system of injectable hydrogels to deliver stem cells to musculoskeletal defects, thereby allowing cells to remain at the treatment site and secrete soluble factors that will facilitate tissue regeneration. First, production parameters for encapsulating cells in microbeads were determined. This involved investigating the effects of osmolytes on alginate microbead properties, and the effects of alginate microbead cell density, alginate microbead density, and effects of osteogenic media on microencapsulated cells. Although cells remained viable in the mi

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Bellat, Vanessa. "Ingénierie d'un nouveau nanobiohybride à base de nanorubans de titanates pour la médecine régénérative." Thesis, Dijon, 2012. http://www.theses.fr/2012DIJOS056/document.

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Ce travail de recherche est consacré à l’ingénierie d’un nouveau nanobiohybride à base de nanorubans de titanates pour la médecine régénérative. Dans un premier temps, les nanorubans ont été synthétisés par traitement hydrothermal et leurs caractéristiques morphologiques, structurales et chimiques ont été définies. Une caractérisation fine par différentes techniques de microscopie électronique à transmission a notamment permis de déterminer leur épaisseur; dimension qui n’avait encore jamais été mesurée. Par la suite, les nanorubans de titanates ont été fonctionnalisés par différents PEG hétér

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Rolland, Leslie. "Propriétés physico-chimiques de capsules d'hydrogel à coeur liquide." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2013. http://tel.archives-ouvertes.fr/tel-00919083.

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Ce travail de thèse concerne l'étude des propriétés physico-chimiques de capsules millimétriques à cœur liquide possédant une membrane fine d'hydrogel d'alginate. Nous avons dans un premier temps caractérisé le transport de molécules à travers la coque d'hydrogel et estimé le rayon de coupure de cette membrane semi-perméable. De plus, il est possible de limiter la fuite de petits solutés hydrophiles en ajoutant une couche hydrophobe entre le cœur aqueux et la membrane d'alginate. Nous démontrons alors que le temps caractéristique de fuite est déterminé par la géométrie du système (épaisseur de

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Xu, Juanbao. "Fabrication of Osmotic Distillation Membranes for Feeds Containing Surface-Active Agents." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16049/1/Juanbao_Xu_Thesis.pdf.

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The present work was undertaken to develop a composite osmotic distillation (OD) membrane consisting of a thin hydrogel coating on a microporous hydrophobic substrate for the concentration of aqueous feeds containing surface-active agents. The range of OD applications using the hydrophobic membrane alone have been severely limited by the propensity for membrane wet-out when contacted by amphiphilic agents such as oils, fats and detergents. Wet-out allows the feed solution to track freely through the membrane pores with a resulting loss of solutes and a decrease in selectivity. The rationale fo

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Xu, Juanbao. "Fabrication of Osmotic Distillation Membranes for Feeds Containing Surface-Active Agents." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16049/.

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The present work was undertaken to develop a composite osmotic distillation (OD) membrane consisting of a thin hydrogel coating on a microporous hydrophobic substrate for the concentration of aqueous feeds containing surface-active agents. The range of OD applications using the hydrophobic membrane alone have been severely limited by the propensity for membrane wet-out when contacted by amphiphilic agents such as oils, fats and detergents. Wet-out allows the feed solution to track freely through the membrane pores with a resulting loss of solutes and a decrease in selectivity. The rationale fo

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Klímová, Eliška. "Mechanické a transportní vlastnosti hybridních hydrogelových systémů." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-444534.

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This master´s thesis deals with the study on mechanical and transport properties of hybrid hydrogel systems. Considering applications of hydrogels, especially in chemical industry, pharmacy, or eventually medical applications, for the study gellan and alginate-based hydrogels were selected. In order to compare individual characteristics physical and hybrid hydrogels were prepared. Gellan hydrogels were prepared in deionization aqua solution, calcium chloride dihydrate and tween 80 solution. Alginate hydrogels were prepared in calcium chloride dihydrate solution as well, and polyacrylamide with

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Partap, Sonia. "Controlled porosity alginate hydrogels from emulsion templating techniques." Thesis, Queen Mary, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429360.

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Balášová, Patricie. "Příprava a charakterizace moderních krytů ran." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-449701.

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This diploma thesis is focused on the study of bioactive wound dressings. During the thesis, hydrogel, lyophilized and nanofiber wound dressings were prepared. Hydrogel and lyophilized wound dressings were prepared on basis of two polysaccharides – alginate and chitosan. Nanofiber wound dressings were prepared by spinning polyhydroxybutyrate. All prepared wound dressings were enriched with bioactive substances, which represented analgesics (ibuprofen), antibiotics (ampicillin) and enzymes (collagenase). Into hydrogel and lyophilized wound dressings were all the mentioned active substances inco

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Bozza, Angela. "Alginate-based Hydrogels for Central Nervous System Tissue Regeneration." Doctoral thesis, Università degli studi di Trento, 2015. https://hdl.handle.net/11572/368725.

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As the central nervous system shows very little capability for self-repair following injury, regenerative medicine approaches are increasingly interested in the use of stem cells for cell replacement strategies. Biomaterials are an interesting tool to carry out this type of therapies. They allow three-dimensional cultures for stem cells differentiation and are helpful in order to obtain cells at the right developmental stage for transplantation. Moreover, they could help to enhance and control cell survival after transplantation, minimizing cell death. Stroke is a very severe form of brain inj

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Bozza, Angela. "Alginate-based Hydrogels for Central Nervous System Tissue Regeneration." Doctoral thesis, University of Trento, 2015. http://eprints-phd.biblio.unitn.it/1546/1/BozzaAngela_PhDThesis_FINAL.pdf.

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As the central nervous system shows very little capability for self-repair following injury, regenerative medicine approaches are increasingly interested in the use of stem cells for cell replacement strategies. Biomaterials are an interesting tool to carry out this type of therapies. They allow three-dimensional cultures for stem cells differentiation and are helpful in order to obtain cells at the right developmental stage for transplantation. Moreover, they could help to enhance and control cell survival after transplantation, minimizing cell death. Stroke is a very severe form of brain inj

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Candráková, Simona. "Adhezní vlastnosti semi-IPN hydrogelů." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2020. http://www.nusl.cz/ntk/nusl-433088.

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This Diploma thesis deals with optimization of the hydrogel preparation with various additions of substances affecting adhesion, studying the adhesion of prepared hydrogel systems and modifying their adhesion properties. Prepared hydrogels were agarose, alginate and gellan polymer systems with additions of acrylic acid, acrylamide, calcium chloride and Tween 20. The experimental part of the diploma thesis focuses first on optimizing the preparation of individual hydrogels, from which, according to certain criteria, suitable representatives were selected to study adhesion and its controlled mod

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Lizardo, Daniel (Daniel H. ). "Architectural scale biomimetic composites based on chitosan and alginate hydrogels." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98654.

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Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, June 2015.<br>Cataloged from PDF version of thesis. "May 2015."<br>Includes bibliographical references (pages 44-46).<br>Developmental research and characterization was conducted on novel biomaterials for a larger project of product and architectural scale digital fabrication using natural bioplastics and hierarchical computational design carried out by the Mediated Matter team, led by Laia Mogas-Soldevila and Jorge Duro-Royo. Chitosan and alginate (among other natural polymers) are processed

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Ahmad, Hajira Fatima. "Cryopreservation effects on a pancreatic substitute comprised of beta cells or recombinant myoblasts encapsulated in non-adhesive and adhesive alginate hydrogels." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/48968.

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For clinical translation of a pancreatic substitute, long-term storage is essential, and cryopreservation is a promising means to achieve this goal. The two main cryopreservation methods are conventional freezing and vitrification, or ice-free cryopreservation. However, as both methods have their potential drawbacks for cryopreservation of a pancreatic substitute, they must be systematically evaluated in order to determine the appropriate method of cryopreservation. Furthermore, previous studies have indicated benefits to encapsulation in 3-D adhesive environments for pancreatic substitutes an

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Perin, Danilo. "Biomaterials for biotechnological applications: synthesis and activity evaluations." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3518.

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2008/2009<br>A biomaterial was defined as any non-living material used in a medical device that interacts with biological systems. Many different applications involve the use of biomaterials: pharmacology, controlled drug release, extracorporeal devices (contact lens, emodialysis devices, cardiopulmonary bypass oxygenators), artificial prostheses. One of the most interesting biomaterials application regards the release of nucleic acids and their derivatives as therapeutic agents. These molecules, defined as “nucleic acid base drugs” (NABDs), allows highly targeted cellular metabolism modificat

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Knaack, Sven. "Entwicklung und Charakterisierung von Scaffolds auf Basis von mineralisiertem Kollagen zur gezielten Wirkstofffreisetzung für die Knochengewebe-Regeneration." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-188547.

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Beim Tissue Engineering ist die Vaskularisierung von größeren Zell-Matrix-Konstrukten nach Implantation bis heute ein großes Problem. Durch das initiale Fehlen eines mikrovaskulären Netzwerkes kommt es zu einem raschen Zellsterben im Scaffold. Aufgrund dessen war das Ziel dieser Arbeit, im Sinne des in situ-Tissue Engineering ein Scaffold auf Basis von mineralisiertem Kollagen zu entwickeln, welches mit dem angiogenen Wachstumsfaktor VEGF funktionalisiert wird, um den Prozess der Vaskularisierung – die Einsprossung von Blutgefäßen – zu fördern und gleichzeitig durch Chemoattraktion in vivo Z

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Rafat, Marjan. "Dual Antibody Functionalized Polyvinyl Alcohol and Alginate Hydrogels for Synergistic Endothelial Cell Adhesion." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10100.

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Motivated by the need to design minimally-invasive treatments for wide-necked cerebral aneurysms, we used computational modeling to assess aneurysm hemodynamics, examined in vitro cellular responses arising from mechanical and chemical stresses, and designed novel materials that cooperatively adhere to the endothelium. We first hypothesized that because aneurysm geometry plays an important role in hemodynamics, changes in flow patterns may affect the shear stress experienced on the aneurysm wall. We defined flow regimes based on aneurysm hemodynamic and geometric parameters, which may correlat

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Hori, Yuki. "In vivo generation of 'vaccination nodes' using injectable alginate hydrogels for cancer immunotherapy." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/53244.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 78-90).<br>Despite the amount of ongoing intensive research, tumor cells have continued to outwit us in the effort to combat and prevent cancer by exerting a number of mechanisms to evade and suppress anti-tumor immune responses. The present work employs strategies to generate a synthetic extranodal immunoplatform that can harbor both exogenously provided and endogenously recruited immune cells (primed agai

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Mazens, Delphine. "Étude du transfert diffusionnel de solutés macromoléculaires dans les hydrogels d'alginate de calcium." Vandoeuvre-les-Nancy, INPL, 2005. http://docnum.univ-lorraine.fr/public/INPL/2005_MAZENS_D.pdf.

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Ce travail porte sur l'étude de la diffusion de solutés macromoléculaires (des pullulanes de masse moléculaire Mw comprise entre 780 et 788 000 g. Mol-1) dans des particules sphériques de gels d'alginate de calcium de fraction volumique PhiP variable. La variation de Mw et PhiP a ainsi permis de balayer une large gamme de situations expérimentales par l'intermédiaire de variations de la taille du soluté et de la densité du réseau. Le suivi des cinétiques de diffusion a été réalisé grâce à la mise en œuvre de 3 types d'essais : suivi après dosage de prélèvements au cours du temps, essais sans p

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Mazens, Delphine Favre Eric. "Étude du transfert diffusionnel de solutés macromoléculaires dans les hydrogels d'alginate de calcium." Vandoeuvre-les-Nancy : INPL, 2005. http://www.scd.inpl-nancy.fr/theses/2005_MAZENS_D.pdf.

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Anderson, Erin Michelle. "Endothelial Progenitor Cell Recruitment for Therapeutic Neovascularization using Alginate Hydrogels for VEGF and SDF Delivery." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11330.

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Endothelial progenitor cells are potentially useful as a cell therapy for the treatment of ischemic cardiovascular diseases, but clinical outcomes have been limited likely because very few systemically delivered cells reach the target tissue. Biomaterials may improve outcomes of endothelial progenitor-based therapies because they can generate well-defined microenvironments capable of directing cell behavior. The hypothesis guiding this thesis is that local, sustained delivery of exogenous Vascular Endothelial Growth Factor (VEGF) and Stromal Cell-Derived Factor (SDF) from alginate hydrogels ca

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Charron, Patrick Nelson. "Burst Pressure Properties and Ex Vivo Analysis of Alginate-Based Hydrogels for Tissue Sealant Applications." ScholarWorks @ UVM, 2015. http://scholarworks.uvm.edu/graddis/454.

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Lung diseases, cancers, and trauma can result in injury to the connective tissue lining the lung, i.e., the pleura. Pleural injuries lead to pneumothoraxes or pleural effusions, i.e., air or fluid leaking out of the lung respectively, and potential lung collapse - an immediately life threatening condition. While several bioengineered soft tissue sealants exist on the market, there is only one sealant FDA-approved for use in pulmonary surgery. In addition, very limited techniques are presented in the literature for characterizing the burst properties of hydrogel tissue sealants. For my thesis,

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Honiball, John Robert. "Development of a low-cost bioprinting system for the fabrication of cell-laden sodium alginate hydrogels." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/59204.

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Gasmi, Sarah Nawel. "Action d'une hydrolase dans des hydrogels à base d'alginate et d'alginate fonctionnalisé." Rouen, 2015. http://www.theses.fr/2015ROUES049.

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L'objectif de ce travail a été d'étudier l'activité hydrolytique d'une enzyme, la pullulanase, vis à vis du pullulane dans des hydrogels fonctionnalisés ou non à base d'alginate de calcium. L'alginate a été modifié chimiquement par une polyéther amine de la famille Jeffamine® qui présente un caractère LCST "Low Critical Solubility Temperature". L'enzyme immobilisée à hauteur de 30% dans des billes d'alginate de calcium hydrolyse lentement le pullulane en raison de la pénétration de celui ci dans les billes et libère du maltotriose et ses premiers multiples alors que l'enzyme libre donne un mél

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